WO2017217441A1 - 新規ピリドンカルボン酸誘導体又はその塩 - Google Patents
新規ピリドンカルボン酸誘導体又はその塩 Download PDFInfo
- Publication number
- WO2017217441A1 WO2017217441A1 PCT/JP2017/021899 JP2017021899W WO2017217441A1 WO 2017217441 A1 WO2017217441 A1 WO 2017217441A1 JP 2017021899 W JP2017021899 W JP 2017021899W WO 2017217441 A1 WO2017217441 A1 WO 2017217441A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- amino
- fluoro
- oxo
- dihydroquinoline
- Prior art date
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- 150000003839 salts Chemical class 0.000 title claims abstract description 52
- YSLIPUSJNFIFAB-UHFFFAOYSA-N 2-oxopyridine-1-carboxylic acid Chemical class OC(=O)N1C=CC=CC1=O YSLIPUSJNFIFAB-UHFFFAOYSA-N 0.000 title claims abstract description 40
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 66
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 40
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 36
- 125000003277 amino group Chemical group 0.000 claims abstract description 32
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 26
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 20
- 125000003282 alkyl amino group Chemical group 0.000 claims abstract description 17
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 16
- 125000005843 halogen group Chemical group 0.000 claims abstract description 15
- 125000004122 cyclic group Chemical group 0.000 claims abstract description 10
- -1 tetrahydropyran-4-ylamino group Chemical group 0.000 claims description 228
- 239000000203 mixture Substances 0.000 claims description 222
- 125000006239 protecting group Chemical group 0.000 claims description 42
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 24
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 20
- 125000003545 alkoxy group Chemical group 0.000 claims description 18
- 229910052799 carbon Inorganic materials 0.000 claims description 16
- 125000001424 substituent group Chemical group 0.000 claims description 15
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 14
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 9
- 238000001727 in vivo Methods 0.000 claims description 8
- 208000035473 Communicable disease Diseases 0.000 claims description 7
- 229910052801 chlorine Inorganic materials 0.000 claims description 7
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 7
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 6
- 229910052731 fluorine Inorganic materials 0.000 claims description 5
- 125000001153 fluoro group Chemical group F* 0.000 claims description 5
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 5
- 125000005276 alkyl hydrazino group Chemical group 0.000 claims description 4
- 125000004567 azetidin-3-yl group Chemical group N1CC(C1)* 0.000 claims description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 125000004353 pyrazol-1-yl group Chemical group [H]C1=NN(*)C([H])=C1[H] 0.000 claims description 2
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 11
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract description 10
- 241000894006 Bacteria Species 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 9
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 abstract description 7
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 7
- 229960003085 meticillin Drugs 0.000 abstract description 7
- 241000193163 Clostridioides difficile Species 0.000 abstract description 6
- 150000001875 compounds Chemical class 0.000 description 415
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 373
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 294
- 239000000243 solution Substances 0.000 description 278
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 273
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 237
- 238000005160 1H NMR spectroscopy Methods 0.000 description 222
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 216
- 238000001914 filtration Methods 0.000 description 205
- 238000006243 chemical reaction Methods 0.000 description 201
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 189
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 175
- 230000002829 reductive effect Effects 0.000 description 167
- 229910001868 water Inorganic materials 0.000 description 162
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 156
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 139
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 131
- 239000002244 precipitate Substances 0.000 description 131
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 117
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 109
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 108
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 108
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 105
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 102
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 100
- 239000007864 aqueous solution Substances 0.000 description 99
- 239000002904 solvent Substances 0.000 description 82
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 78
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 71
- 239000012044 organic layer Substances 0.000 description 58
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 54
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 53
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 50
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 50
- 229920006395 saturated elastomer Polymers 0.000 description 50
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 49
- 235000017557 sodium bicarbonate Nutrition 0.000 description 48
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 48
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 42
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 38
- 238000003756 stirring Methods 0.000 description 38
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 38
- 239000000843 powder Substances 0.000 description 37
- 239000007787 solid Substances 0.000 description 37
- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 36
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 35
- 238000010898 silica gel chromatography Methods 0.000 description 35
- KYVBNYUBXIEUFW-UHFFFAOYSA-N 1,1,3,3-tetramethylguanidine Chemical compound CN(C)C(=N)N(C)C KYVBNYUBXIEUFW-UHFFFAOYSA-N 0.000 description 34
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 33
- AVFZOVWCLRSYKC-UHFFFAOYSA-N 1-methylpyrrolidine Chemical compound CN1CCCC1 AVFZOVWCLRSYKC-UHFFFAOYSA-N 0.000 description 32
- AHVYPIQETPWLSZ-UHFFFAOYSA-N N-methyl-pyrrolidine Natural products CN1CC=CC1 AHVYPIQETPWLSZ-UHFFFAOYSA-N 0.000 description 32
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 32
- 238000001816 cooling Methods 0.000 description 32
- 239000013078 crystal Substances 0.000 description 32
- 239000011541 reaction mixture Substances 0.000 description 30
- 230000035484 reaction time Effects 0.000 description 30
- 239000000725 suspension Substances 0.000 description 30
- LINDOXZENKYESA-UHFFFAOYSA-N TMG Natural products CNC(N)=NC LINDOXZENKYESA-UHFFFAOYSA-N 0.000 description 29
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 28
- 239000000706 filtrate Substances 0.000 description 28
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 28
- 230000002378 acidificating effect Effects 0.000 description 25
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 24
- 235000011054 acetic acid Nutrition 0.000 description 23
- 125000004566 azetidin-1-yl group Chemical group N1(CCC1)* 0.000 description 23
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 21
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 20
- 239000002253 acid Substances 0.000 description 20
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 description 20
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 19
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 18
- 238000010511 deprotection reaction Methods 0.000 description 18
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 18
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 18
- 239000006228 supernatant Substances 0.000 description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 17
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 16
- 150000002170 ethers Chemical class 0.000 description 16
- 239000002198 insoluble material Substances 0.000 description 16
- 238000010908 decantation Methods 0.000 description 15
- 239000002798 polar solvent Substances 0.000 description 15
- LJJXJSKLSMCGCI-UHFFFAOYSA-N CC1=C2C(=C(C(=C1F)F)Cl)N(C=C(C2=O)C(=O)O)C3=CC(=C(C=C3CO)F)N Chemical compound CC1=C2C(=C(C(=C1F)F)Cl)N(C=C(C2=O)C(=O)O)C3=CC(=C(C=C3CO)F)N LJJXJSKLSMCGCI-UHFFFAOYSA-N 0.000 description 14
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 14
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 14
- GHBUOTIRANXFEE-UHFFFAOYSA-N ethyl 1,4-dihydroquinoline-3-carboxylate Chemical compound C1=CC=C2CC(C(=O)OCC)=CNC2=C1 GHBUOTIRANXFEE-UHFFFAOYSA-N 0.000 description 14
- JGQULHKPDGZAMH-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-8-chloro-6,7-difluoro-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2c(Cl)c(F)c(F)cc2c1=O JGQULHKPDGZAMH-UHFFFAOYSA-N 0.000 description 14
- 229910052739 hydrogen Inorganic materials 0.000 description 14
- 229910000027 potassium carbonate Inorganic materials 0.000 description 14
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 14
- 239000008096 xylene Substances 0.000 description 14
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 13
- 238000007080 aromatic substitution reaction Methods 0.000 description 13
- 239000005457 ice water Substances 0.000 description 13
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 12
- MQMXSHBNOLRHRA-UHFFFAOYSA-N ethyl 1,2-dihydroquinoline-3-carboxylate Chemical compound C1=CC=C2NCC(C(=O)OCC)=CC2=C1 MQMXSHBNOLRHRA-UHFFFAOYSA-N 0.000 description 12
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 12
- 238000010992 reflux Methods 0.000 description 12
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 12
- 239000012448 Lithium borohydride Substances 0.000 description 11
- GWXVMZPIEZPCGO-UHFFFAOYSA-N azetidin-3-ol;2,3-dihydroxybutanedioic acid Chemical compound OC1CNC1.OC(=O)C(O)C(O)C(O)=O GWXVMZPIEZPCGO-UHFFFAOYSA-N 0.000 description 11
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 description 11
- 150000008282 halocarbons Chemical class 0.000 description 11
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 10
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 10
- 238000007363 ring formation reaction Methods 0.000 description 10
- GKASDNZWUGIAMG-UHFFFAOYSA-N triethyl orthoformate Chemical compound CCOC(OCC)OCC GKASDNZWUGIAMG-UHFFFAOYSA-N 0.000 description 10
- NJCVMXOXJGLUEB-UHFFFAOYSA-N C(C)(=O)OCC1=C(C=C(C(=C1)F)N)N1C=C(C(C2=CC(=C(C(=C12)Cl)F)F)=O)C(=O)O Chemical compound C(C)(=O)OCC1=C(C=C(C(=C1)F)N)N1C=C(C(C2=CC(=C(C(=C12)Cl)F)F)=O)C(=O)O NJCVMXOXJGLUEB-UHFFFAOYSA-N 0.000 description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 9
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N N-phenyl amine Natural products NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 9
- 238000005481 NMR spectroscopy Methods 0.000 description 9
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 9
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 9
- 238000001035 drying Methods 0.000 description 9
- RBVLUTAXWVILBT-UHFFFAOYSA-N ethyl prop-2-eneperoxoate Chemical compound CCOOC(=O)C=C RBVLUTAXWVILBT-UHFFFAOYSA-N 0.000 description 9
- 239000003921 oil Substances 0.000 description 9
- 235000019198 oils Nutrition 0.000 description 9
- 239000012312 sodium hydride Substances 0.000 description 9
- 229910000104 sodium hydride Inorganic materials 0.000 description 9
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 9
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 8
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 8
- 125000006308 propyl amino group Chemical group 0.000 description 8
- 239000000741 silica gel Substances 0.000 description 8
- 229910002027 silica gel Inorganic materials 0.000 description 8
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 description 7
- SCZNXLWKYFICFV-UHFFFAOYSA-N 1,2,3,4,5,7,8,9-octahydropyrido[1,2-b]diazepine Chemical compound C1CCCNN2CCCC=C21 SCZNXLWKYFICFV-UHFFFAOYSA-N 0.000 description 7
- DTYLXDLAOLOTKT-UHFFFAOYSA-N 1,4-dihydroquinoline-3-carboxylic acid Chemical compound C1=CC=C2CC(C(=O)O)=CNC2=C1 DTYLXDLAOLOTKT-UHFFFAOYSA-N 0.000 description 7
- ZCUKOTWVJTYNOF-UHFFFAOYSA-N 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-6,7-difluoro-5,8-dimethyl-4-oxoquinoline-3-carboxylic acid Chemical compound NC=1C(=CC(=C(C=1)N1C=C(C(C2=C(C(=C(C(=C12)C)F)F)C)=O)C(=O)O)CO)F ZCUKOTWVJTYNOF-UHFFFAOYSA-N 0.000 description 7
- DVSIPNSKXUIBAQ-UHFFFAOYSA-N C(C)(=O)OCC1=C(C=C(C(=C1)F)N)N1C=C(C(C2=CC(=C(C(=C12)Br)F)F)=O)C(=O)O Chemical compound C(C)(=O)OCC1=C(C=C(C(=C1)F)N)N1C=C(C(C2=CC(=C(C(=C12)Br)F)F)=O)C(=O)O DVSIPNSKXUIBAQ-UHFFFAOYSA-N 0.000 description 7
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 7
- WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 description 7
- 229910001629 magnesium chloride Inorganic materials 0.000 description 7
- 239000004323 potassium nitrate Substances 0.000 description 7
- 235000010333 potassium nitrate Nutrition 0.000 description 7
- ZRAZJGBWNZUSGQ-UHFFFAOYSA-N (2-amino-5-fluorophenyl)methanol Chemical compound NC1=CC=C(F)C=C1CO ZRAZJGBWNZUSGQ-UHFFFAOYSA-N 0.000 description 6
- LVVYHEVANKFBAZ-UHFFFAOYSA-N C(C)(=O)OCC1=C(C=C(C(=C1)F)N)N1C=C(C(C2=CC(=C(C=C12)F)F)=O)C(=O)O Chemical compound C(C)(=O)OCC1=C(C=C(C(=C1)F)N)N1C=C(C(C2=CC(=C(C=C12)F)F)=O)C(=O)O LVVYHEVANKFBAZ-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 6
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 6
- 150000001241 acetals Chemical class 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 6
- 125000003342 alkenyl group Chemical group 0.000 description 6
- 125000003118 aryl group Chemical group 0.000 description 6
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- QENWGUSEEFSVPU-UHFFFAOYSA-N ethyl 5-amino-1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-chloro-6,7-difluoro-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2CO)c2c(Cl)c(F)c(F)c(N)c2c1=O QENWGUSEEFSVPU-UHFFFAOYSA-N 0.000 description 6
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- KBKDCBZELBBQQI-UHFFFAOYSA-N n-methylazetidin-3-amine;dihydrochloride Chemical compound Cl.Cl.CNC1CNC1 KBKDCBZELBBQQI-UHFFFAOYSA-N 0.000 description 6
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 6
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- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 6
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- 238000006722 reduction reaction Methods 0.000 description 6
- 229910000029 sodium carbonate Inorganic materials 0.000 description 6
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 6
- ZCEDZRGTVPYTMN-UHFFFAOYSA-N 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-5-bromo-6,7-difluoro-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound Cc1c(F)c(F)c(Br)c2c1n(cc(C(O)=O)c2=O)-c1cc(N)c(F)cc1CO ZCEDZRGTVPYTMN-UHFFFAOYSA-N 0.000 description 5
- MONYNKGRGSIEKM-UHFFFAOYSA-N 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-bromo-6,7-difluoro-5-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound CC1=C2C(=C(C(=C1F)F)Br)N(C=C(C2=O)C(=O)O)C3=CC(=C(C=C3CO)F)N MONYNKGRGSIEKM-UHFFFAOYSA-N 0.000 description 5
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- 150000001298 alcohols Chemical class 0.000 description 5
- OOSDLMAZIRAMDN-UHFFFAOYSA-N azetidin-3-amine;dihydrochloride Chemical compound Cl.Cl.NC1CNC1 OOSDLMAZIRAMDN-UHFFFAOYSA-N 0.000 description 5
- 239000002585 base Substances 0.000 description 5
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 150000002148 esters Chemical group 0.000 description 5
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 5
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 5
- IUVWNLGZKLFAGU-UHFFFAOYSA-N n-methylazetidin-3-amine;hydrochloride Chemical compound Cl.CNC1CNC1 IUVWNLGZKLFAGU-UHFFFAOYSA-N 0.000 description 5
- 238000006386 neutralization reaction Methods 0.000 description 5
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- 239000000047 product Substances 0.000 description 5
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 5
- DKZIQVJBUFPADP-UHFFFAOYSA-N 1-[2-(acetyloxymethyl)-4-fluoro-5-nitrophenyl]-8-bromo-6,7-difluoro-4-oxoquinoline-3-carboxylic acid Chemical compound C(C)(=O)OCC1=C(C=C(C(=C1)F)[N+](=O)[O-])N1C=C(C(C2=CC(=C(C(=C12)Br)F)F)=O)C(=O)O DKZIQVJBUFPADP-UHFFFAOYSA-N 0.000 description 4
- LGNMKWGLOPHDJQ-UHFFFAOYSA-N 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-6,7-difluoro-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound NC=1C(=CC(=C(C=1)N1C=C(C(C2=CC(=C(C(=C12)C)F)F)=O)C(=O)O)CO)F LGNMKWGLOPHDJQ-UHFFFAOYSA-N 0.000 description 4
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 4
- 125000002252 acyl group Chemical group 0.000 description 4
- YQXHUNCYUWWGEV-UHFFFAOYSA-N azetidin-3-amine;hydrochloride Chemical compound Cl.NC1CNC1 YQXHUNCYUWWGEV-UHFFFAOYSA-N 0.000 description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 4
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- 238000002512 chemotherapy Methods 0.000 description 4
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- YBEOYBKKSWUSBR-UHFFFAOYSA-N ethyl 4-oxo-1h-quinoline-3-carboxylate Chemical compound C1=CC=C2C(=O)C(C(=O)OCC)=CNC2=C1 YBEOYBKKSWUSBR-UHFFFAOYSA-N 0.000 description 4
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- 238000007429 general method Methods 0.000 description 4
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- HSZCZNFXUDYRKD-UHFFFAOYSA-M lithium iodide Chemical compound [Li+].[I-] HSZCZNFXUDYRKD-UHFFFAOYSA-M 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
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- NQPTWMKTGPWPMX-UHFFFAOYSA-N n-methylazetidin-3-amine Chemical compound CNC1CNC1 NQPTWMKTGPWPMX-UHFFFAOYSA-N 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- YPJUNDFVDDCYIH-UHFFFAOYSA-N perfluorobutyric acid Chemical compound OC(=O)C(F)(F)C(F)(F)C(F)(F)F YPJUNDFVDDCYIH-UHFFFAOYSA-N 0.000 description 4
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 description 4
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- WVUCPRGADMCTBN-UHFFFAOYSA-M potassium;3-ethoxy-3-oxopropanoate Chemical compound [K+].CCOC(=O)CC([O-])=O WVUCPRGADMCTBN-UHFFFAOYSA-M 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
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- CBFPUTHGTJAPRV-UHFFFAOYSA-N 1-[2-(acetyloxymethyl)-4-fluoro-5-nitrophenyl]-6,7-difluoro-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound C(C)(=O)OCC1=C(C=C(C(=C1)F)[N+](=O)[O-])N1C=C(C(C2=CC(=C(C(=C12)C)F)F)=O)C(=O)O CBFPUTHGTJAPRV-UHFFFAOYSA-N 0.000 description 3
- KWXLWLANZWWNAU-UHFFFAOYSA-N 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-chloro-6-fluoro-7-[3-(2-hydroxyethylamino)azetidin-1-yl]-5-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound Cc1c(F)c(N2CC(C2)NCCO)c(Cl)c2n(cc(C(O)=O)c(=O)c12)-c1cc(N)c(F)cc1CO KWXLWLANZWWNAU-UHFFFAOYSA-N 0.000 description 3
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 3
- KBESHLYCSZINAJ-UHFFFAOYSA-N 3-chloro-2,4,5-trifluorobenzoic acid Chemical compound OC(=O)C1=CC(F)=C(F)C(Cl)=C1F KBESHLYCSZINAJ-UHFFFAOYSA-N 0.000 description 3
- QCLFSYYUWPUWQR-UHFFFAOYSA-N 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one Chemical compound CC=1OC(=O)OC=1CCl QCLFSYYUWPUWQR-UHFFFAOYSA-N 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 3
- HBMFYODZUCYNKJ-UHFFFAOYSA-N C(C)(=O)OCC1=C(C=C(C(=C1)F)N)N1C=C(C(C2=CC(=C(C(=C12)F)F)F)=O)C(=O)O Chemical compound C(C)(=O)OCC1=C(C=C(C(=C1)F)N)N1C=C(C(C2=CC(=C(C(=C12)F)F)F)=O)C(=O)O HBMFYODZUCYNKJ-UHFFFAOYSA-N 0.000 description 3
- DFVYOEWFOJYXQS-UHFFFAOYSA-N CC[K].OC(=O)CC(O)=O Chemical compound CC[K].OC(=O)CC(O)=O DFVYOEWFOJYXQS-UHFFFAOYSA-N 0.000 description 3
- UQGMINQJOUYYMB-UHFFFAOYSA-N Cl.O1CCC(CC1)C1CN(C1)N Chemical compound Cl.O1CCC(CC1)C1CN(C1)N UQGMINQJOUYYMB-UHFFFAOYSA-N 0.000 description 3
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- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 3
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- XTSRVEBOCSNUDT-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-6,7,8-trifluoro-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2c(F)c(F)c(F)cc2c1=O XTSRVEBOCSNUDT-UHFFFAOYSA-N 0.000 description 3
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- 238000006276 transfer reaction Methods 0.000 description 3
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- CYPYTURSJDMMMP-WVCUSYJESA-N (1e,4e)-1,5-diphenylpenta-1,4-dien-3-one;palladium Chemical compound [Pd].[Pd].C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 CYPYTURSJDMMMP-WVCUSYJESA-N 0.000 description 2
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- KMXABDFXWCMQJX-UHFFFAOYSA-N 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-6-fluoro-7-(3-hydroxyazetidin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound COc1c(N2CC(O)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)-c1cc(N)c(F)cc1CO KMXABDFXWCMQJX-UHFFFAOYSA-N 0.000 description 2
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- BEAWLPNJHMCFAS-UHFFFAOYSA-N 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-7-(aminomethyl)-8-chloro-6-fluoro-4-oxoquinoline-3-carboxylic acid Chemical compound NCc1c(F)cc2c(c1Cl)n(cc(C(O)=O)c2=O)-c1cc(N)c(F)cc1CO BEAWLPNJHMCFAS-UHFFFAOYSA-N 0.000 description 2
- UHUJDKKLWWMYBN-UHFFFAOYSA-N 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-bromo-6,7-difluoro-4-oxoquinoline-3-carboxylic acid Chemical compound Nc1cc(c(CO)cc1F)-n1cc(C(O)=O)c(=O)c2cc(F)c(F)c(Br)c12 UHUJDKKLWWMYBN-UHFFFAOYSA-N 0.000 description 2
- FGUJFRJOSMYVSF-UHFFFAOYSA-N 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-chloro-6,7-difluoro-4-oxoquinoline-3-carboxylic acid Chemical compound Nc1cc(c(CO)cc1F)-n1cc(C(O)=O)c(=O)c2cc(F)c(F)c(Cl)c12 FGUJFRJOSMYVSF-UHFFFAOYSA-N 0.000 description 2
- BDMLSRVXXBWXSD-UHFFFAOYSA-N 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-chloro-6-fluoro-5-methyl-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid Chemical compound Cc1c(F)c(N2CCNCC2)c(Cl)c2n(cc(C(O)=O)c(=O)c12)-c1cc(N)c(F)cc1CO BDMLSRVXXBWXSD-UHFFFAOYSA-N 0.000 description 2
- LCKAIGSKQLAELI-UHFFFAOYSA-N 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-chloro-6-fluoro-7-[3-(1-hydroxypropan-2-ylamino)azetidin-1-yl]-5-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound CC(CO)NC1CN(C1)c1c(F)c(C)c2c(c1Cl)n(cc(C(O)=O)c2=O)-c1cc(N)c(F)cc1CO LCKAIGSKQLAELI-UHFFFAOYSA-N 0.000 description 2
- CKQGPPYXRUMBKT-UHFFFAOYSA-N 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-chloro-6-fluoro-7-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound COc1c(F)cc2c(c1Cl)n(cc(C(O)=O)c2=O)-c1cc(N)c(F)cc1CO CKQGPPYXRUMBKT-UHFFFAOYSA-N 0.000 description 2
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- NCTZVWWMIVBBEG-UHFFFAOYSA-N 2-(2-chloro-3,6-difluoro-4-methoxycarbonylphenyl)acetic acid Chemical compound ClC1=C(C(=CC(=C1F)C(=O)OC)F)CC(=O)O NCTZVWWMIVBBEG-UHFFFAOYSA-N 0.000 description 2
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- JJZDEAPERXIPIA-UHFFFAOYSA-N 2-bromo-3,4,6-trifluoro-5-methylbenzoic acid Chemical compound Cc1c(F)c(F)c(Br)c(C(O)=O)c1F JJZDEAPERXIPIA-UHFFFAOYSA-N 0.000 description 2
- 125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 2
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- AQXKNIXHFPOZFL-UHFFFAOYSA-N 3-chloro-2,4,5-trifluoro-6-nitrobenzoic acid Chemical compound OC(=O)C1=C(F)C(Cl)=C(F)C(F)=C1[N+]([O-])=O AQXKNIXHFPOZFL-UHFFFAOYSA-N 0.000 description 2
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- UIKUWRHYZRKQML-UHFFFAOYSA-N CC(=O)OCC1=CC(=C(C=C1N2C=C(C(=O)C3=CC(=C(C(=C32)F)N4CCNCC4)F)C(=O)O)N)F Chemical compound CC(=O)OCC1=CC(=C(C=C1N2C=C(C(=O)C3=CC(=C(C(=C32)F)N4CCNCC4)F)C(=O)O)N)F UIKUWRHYZRKQML-UHFFFAOYSA-N 0.000 description 2
- VCCLEQZMUQFKOM-UHFFFAOYSA-N Cl.CC(C)C1CN(C1)N Chemical compound Cl.CC(C)C1CN(C1)N VCCLEQZMUQFKOM-UHFFFAOYSA-N 0.000 description 2
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- FNVUROADLYGAIP-UHFFFAOYSA-N FC=1C(=C2C(C(=CNC2=CC1)C(=O)OCC)=O)C Chemical compound FC=1C(=C2C(C(=CNC2=CC1)C(=O)OCC)=O)C FNVUROADLYGAIP-UHFFFAOYSA-N 0.000 description 2
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- ATUHZOLEPIHGPM-UHFFFAOYSA-N N,3-dimethylazetidin-3-amine dihydrochloride Chemical compound Cl.Cl.CNC1(C)CNC1 ATUHZOLEPIHGPM-UHFFFAOYSA-N 0.000 description 2
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- 229910002651 NO3 Inorganic materials 0.000 description 2
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- 229910019142 PO4 Inorganic materials 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 239000007868 Raney catalyst Substances 0.000 description 2
- 229910000564 Raney nickel Inorganic materials 0.000 description 2
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 2
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- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- DSVGQVZAZSZEEX-UHFFFAOYSA-N [C].[Pt] Chemical compound [C].[Pt] DSVGQVZAZSZEEX-UHFFFAOYSA-N 0.000 description 2
- 150000008065 acid anhydrides Chemical class 0.000 description 2
- 239000003929 acidic solution Substances 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 150000004703 alkoxides Chemical class 0.000 description 2
- 125000004849 alkoxymethyl group Chemical group 0.000 description 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 2
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- 230000029936 alkylation Effects 0.000 description 2
- 238000005804 alkylation reaction Methods 0.000 description 2
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- 150000001491 aromatic compounds Chemical class 0.000 description 2
- VQJJCDGFRSTMEA-UHFFFAOYSA-N azetidin-1-amine dihydrochloride Chemical compound Cl.Cl.NN1CCC1 VQJJCDGFRSTMEA-UHFFFAOYSA-N 0.000 description 2
- GNMZOTQIHJUMJF-UHFFFAOYSA-N azetidine;dihydrochloride Chemical compound Cl.Cl.C1CNC1 GNMZOTQIHJUMJF-UHFFFAOYSA-N 0.000 description 2
- 150000007514 bases Chemical class 0.000 description 2
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 2
- 150000001639 boron compounds Chemical class 0.000 description 2
- 239000012267 brine Substances 0.000 description 2
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 2
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
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- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 description 2
- VRLDVERQJMEPIF-UHFFFAOYSA-N dbdmh Chemical compound CC1(C)N(Br)C(=O)N(Br)C1=O VRLDVERQJMEPIF-UHFFFAOYSA-N 0.000 description 2
- CLPHAYNBNTVRDI-UHFFFAOYSA-N ditert-butyl propanedioate Chemical compound CC(C)(C)OC(=O)CC(=O)OC(C)(C)C CLPHAYNBNTVRDI-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 2
- MCRSPLOUOSCEPZ-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-7-amino-8-chloro-6-fluoro-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2c(Cl)c(N)c(F)cc2c1=O MCRSPLOUOSCEPZ-UHFFFAOYSA-N 0.000 description 2
- ACXQCLCOXPDOQV-UHFFFAOYSA-N ethyl 1-fluoro-4-oxoquinoline-3-carboxylate Chemical compound C1=CC=C2C(=O)C(C(=O)OCC)=CN(F)C2=C1 ACXQCLCOXPDOQV-UHFFFAOYSA-N 0.000 description 2
- QFAMZRUPUPZYSB-UHFFFAOYSA-N ethyl 2-(3-chloro-2,4,5-trifluoro-6-nitrobenzoyl)-3-ethoxyprop-2-enoate Chemical compound CCOC=C(C(=O)OCC)C(=O)C1=C(F)C(Cl)=C(F)C(F)=C1[N+]([O-])=O QFAMZRUPUPZYSB-UHFFFAOYSA-N 0.000 description 2
- YVXDTLUVXNXPAJ-UHFFFAOYSA-N ethyl 2-amino-4-[(2,4-dimethoxyphenyl)methylamino]-5-fluorobenzoate Chemical compound NC1=C(C(=O)OCC)C=C(C(=C1)NCC1=C(C=C(C=C1)OC)OC)F YVXDTLUVXNXPAJ-UHFFFAOYSA-N 0.000 description 2
- ZMRFRDKDGOINGE-UHFFFAOYSA-N ethyl 3-[3-chloro-2,5-difluoro-4-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]phenyl]-3-oxopropanoate Chemical compound CCOC(=O)CC(=O)c1cc(F)c(CNC(=O)OC(C)(C)C)c(Cl)c1F ZMRFRDKDGOINGE-UHFFFAOYSA-N 0.000 description 2
- ITOGWTIVAFNCPU-UHFFFAOYSA-N ethyl 6,7-difluoro-1-[4-fluoro-2-(hydroxymethyl)phenyl]-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2ccc(F)cc2CO)c2cc(F)c(F)cc2c1=O ITOGWTIVAFNCPU-UHFFFAOYSA-N 0.000 description 2
- VQABYTOZZFNTOZ-UHFFFAOYSA-N ethyl 6,7-difluoro-1-[4-fluoro-2-(hydroxymethyl)phenyl]-8-methyl-4-oxoquinoline-3-carboxylate Chemical compound FC=1C=C2C(C(=CN(C2=C(C=1F)C)C1=C(C=C(C=C1)F)CO)C(=O)OCC)=O VQABYTOZZFNTOZ-UHFFFAOYSA-N 0.000 description 2
- MUIHJAPBJJCDGJ-UHFFFAOYSA-N ethyl 6-fluoro-1-[4-fluoro-2-(hydroxymethyl)phenyl]-8-methyl-7-nitro-4-oxoquinoline-3-carboxylate Chemical compound FC=1C=C2C(C(=CN(C2=C(C=1[N+](=O)[O-])C)C1=C(C=C(C=C1)F)CO)C(=O)OCC)=O MUIHJAPBJJCDGJ-UHFFFAOYSA-N 0.000 description 2
- RFJCMFUKBVCUJZ-UHFFFAOYSA-N ethyl 7-amino-1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-6-fluoro-8-methyl-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2CO)c2c(C)c(N)c(F)cc2c1=O RFJCMFUKBVCUJZ-UHFFFAOYSA-N 0.000 description 2
- VVHLMVLAEKARSV-UHFFFAOYSA-N ethyl 8-bromo-6,7-difluoro-1-[4-fluoro-2-(hydroxymethyl)phenyl]-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2ccc(F)cc2CO)c2c(Br)c(F)c(F)cc2c1=O VVHLMVLAEKARSV-UHFFFAOYSA-N 0.000 description 2
- IEUJDAIGTODAOT-UHFFFAOYSA-N ethyl 8-chloro-6,7-difluoro-1-[4-fluoro-2-(hydroxymethyl)phenyl]-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2ccc(F)cc2CO)c2c(Cl)c(F)c(F)cc2c1=O IEUJDAIGTODAOT-UHFFFAOYSA-N 0.000 description 2
- 239000003889 eye drop Substances 0.000 description 2
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- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 2
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
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- 239000007788 liquid Substances 0.000 description 2
- ZCSHNCUQKCANBX-UHFFFAOYSA-N lithium diisopropylamide Chemical compound [Li+].CC(C)[N-]C(C)C ZCSHNCUQKCANBX-UHFFFAOYSA-N 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 229910052987 metal hydride Inorganic materials 0.000 description 2
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 2
- CFDZTZXUHUDFRY-UHFFFAOYSA-N methyl 2-amino-4-[(2,4-dimethoxyphenyl)methylamino]-5-fluorobenzoate Chemical compound NC1=C(C(=O)OC)C=C(C(=C1)NCC1=C(C=C(C=C1)OC)OC)F CFDZTZXUHUDFRY-UHFFFAOYSA-N 0.000 description 2
- APWNWKKSSIBFGF-UHFFFAOYSA-N methyl 3-chloro-2,5-difluoro-4-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]benzoate Chemical compound COC(=O)c1cc(F)c(CNC(=O)OC(C)(C)C)c(Cl)c1F APWNWKKSSIBFGF-UHFFFAOYSA-N 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- IETLPNNWMHRUGS-UHFFFAOYSA-N n-ethylazetidin-3-amine;dihydrochloride Chemical compound Cl.Cl.CCNC1CNC1 IETLPNNWMHRUGS-UHFFFAOYSA-N 0.000 description 2
- 230000000802 nitrating effect Effects 0.000 description 2
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- 229910017604 nitric acid Inorganic materials 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 2
- 125000004193 piperazinyl group Chemical group 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 2
- DJXNJVFEFSWHLY-UHFFFAOYSA-M quinoline-3-carboxylate Chemical compound C1=CC=CC2=CC(C(=O)[O-])=CN=C21 DJXNJVFEFSWHLY-UHFFFAOYSA-M 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- HYHCSLBZRBJJCH-UHFFFAOYSA-M sodium hydrosulfide Chemical compound [Na+].[SH-] HYHCSLBZRBJJCH-UHFFFAOYSA-M 0.000 description 2
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- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- 239000003206 sterilizing agent Substances 0.000 description 2
- XIUROWKZWPIAIB-UHFFFAOYSA-N sulfotep Chemical compound CCOP(=S)(OCC)OP(=S)(OCC)OCC XIUROWKZWPIAIB-UHFFFAOYSA-N 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 229910052718 tin Inorganic materials 0.000 description 2
- 239000011135 tin Substances 0.000 description 2
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- PYOKUURKVVELLB-UHFFFAOYSA-N trimethyl orthoformate Chemical compound COC(OC)OC PYOKUURKVVELLB-UHFFFAOYSA-N 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- VCGRFBXVSFAGGA-UHFFFAOYSA-N (1,1-dioxo-1,4-thiazinan-4-yl)-[6-[[3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone Chemical compound CC=1ON=C(C=2C=CC(F)=CC=2)C=1COC(N=C1)=CC=C1C(=O)N1CCS(=O)(=O)CC1 VCGRFBXVSFAGGA-UHFFFAOYSA-N 0.000 description 1
- QOWBXWFYRXSBAS-UHFFFAOYSA-N (2,4-dimethoxyphenyl)methanamine Chemical compound COC1=CC=C(CN)C(OC)=C1 QOWBXWFYRXSBAS-UHFFFAOYSA-N 0.000 description 1
- MAYZWDRUFKUGGP-VIFPVBQESA-N (3s)-1-[5-tert-butyl-3-[(1-methyltetrazol-5-yl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol Chemical compound CN1N=NN=C1CN1C2=NC(C(C)(C)C)=NC(N3C[C@@H](O)CC3)=C2N=N1 MAYZWDRUFKUGGP-VIFPVBQESA-N 0.000 description 1
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- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 description 1
- JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical compound C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- 229940092714 benzenesulfonic acid Drugs 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- HSDAJNMJOMSNEV-UHFFFAOYSA-N benzyl chloroformate Chemical compound ClC(=O)OCC1=CC=CC=C1 HSDAJNMJOMSNEV-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 description 1
- 238000005893 bromination reaction Methods 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- CNDRVWRHLXAABB-UHFFFAOYSA-N butanoyl 2,2-dimethylpropanoate Chemical compound CCCC(=O)OC(=O)C(C)(C)C CNDRVWRHLXAABB-UHFFFAOYSA-N 0.000 description 1
- YHASWHZGWUONAO-UHFFFAOYSA-N butanoyl butanoate Chemical compound CCCC(=O)OC(=O)CCC YHASWHZGWUONAO-UHFFFAOYSA-N 0.000 description 1
- 125000004369 butenyl group Chemical group C(=CCC)* 0.000 description 1
- 125000006309 butyl amino group Chemical group 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 150000001733 carboxylic acid esters Chemical class 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000007810 chemical reaction solvent Substances 0.000 description 1
- 229960003405 ciprofloxacin Drugs 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000012024 dehydrating agents Substances 0.000 description 1
- FVTHQGOGQRTOMY-UHFFFAOYSA-N dibenzyl chloromethyl phosphate Chemical compound C=1C=CC=CC=1COP(=O)(OCCl)OCC1=CC=CC=C1 FVTHQGOGQRTOMY-UHFFFAOYSA-N 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 229940043279 diisopropylamine Drugs 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- BADXJIPKFRBFOT-UHFFFAOYSA-N dimedone Chemical compound CC1(C)CC(=O)CC(=O)C1 BADXJIPKFRBFOT-UHFFFAOYSA-N 0.000 description 1
- IUNMPGNGSSIWFP-UHFFFAOYSA-N dimethylaminopropylamine Chemical compound CN(C)CCCN IUNMPGNGSSIWFP-UHFFFAOYSA-N 0.000 description 1
- MKRTXPORKIRPDG-UHFFFAOYSA-N diphenylphosphoryl azide Chemical compound C=1C=CC=CC=1P(=O)(N=[N+]=[N-])C1=CC=CC=C1 MKRTXPORKIRPDG-UHFFFAOYSA-N 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- IDYZIJYBMGIQMJ-UHFFFAOYSA-N enoxacin Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 IDYZIJYBMGIQMJ-UHFFFAOYSA-N 0.000 description 1
- 229960002549 enoxacin Drugs 0.000 description 1
- XWBDWHCCBGMXKG-UHFFFAOYSA-N ethanamine;hydron;chloride Chemical compound Cl.CCN XWBDWHCCBGMXKG-UHFFFAOYSA-N 0.000 description 1
- UESSEMPSSAXQJC-UHFFFAOYSA-N ethanol;methanamine Chemical compound NC.CCO UESSEMPSSAXQJC-UHFFFAOYSA-N 0.000 description 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 description 1
- ITQFPVUDTFABDH-AATRIKPKSA-N ethyl (e)-3-ethoxyprop-2-enoate Chemical compound CCO\C=C\C(=O)OCC ITQFPVUDTFABDH-AATRIKPKSA-N 0.000 description 1
- HHEWFFSIQHVANA-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-4-fluoro-5-nitrophenyl]-6,7,8-trifluoro-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(c(F)cc2COC(C)=O)[N+]([O-])=O)c2c(F)c(F)c(F)cc2c1=O HHEWFFSIQHVANA-UHFFFAOYSA-N 0.000 description 1
- PRISTZJYGPISFL-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-4-fluoro-5-nitrophenyl]-6,7-difluoro-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(c(F)cc2COC(C)=O)[N+]([O-])=O)c2cc(F)c(F)cc2c1=O PRISTZJYGPISFL-UHFFFAOYSA-N 0.000 description 1
- UXGGLWACPGYRCO-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-4-fluoro-5-nitrophenyl]-6,7-difluoro-8-methyl-4-oxoquinoline-3-carboxylate Chemical compound C(C)(=O)OCC1=C(C=C(C(=C1)F)[N+](=O)[O-])N1C=C(C(C2=CC(=C(C(=C12)C)F)F)=O)C(=O)OCC UXGGLWACPGYRCO-UHFFFAOYSA-N 0.000 description 1
- UHIODQIXUXAYLT-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-4-fluoro-5-nitrophenyl]-8-chloro-6,7-difluoro-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(c(F)cc2COC(C)=O)[N+]([O-])=O)c2c(Cl)c(F)c(F)cc2c1=O UHIODQIXUXAYLT-UHFFFAOYSA-N 0.000 description 1
- HRNURLVNVZLDDI-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-6,7-difluoro-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2cc(F)c(F)cc2c1=O HRNURLVNVZLDDI-UHFFFAOYSA-N 0.000 description 1
- RYPWRPDGIDDCHI-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2cc(N3CCNCC3)c(F)cc2c1=O RYPWRPDGIDDCHI-UHFFFAOYSA-N 0.000 description 1
- BQOHAZZLTDECNX-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-7-(3-amino-3-methylazetidin-1-yl)-8-bromo-6-fluoro-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2c(Br)c(N3CC(C)(N)C3)c(F)cc2c1=O BQOHAZZLTDECNX-UHFFFAOYSA-N 0.000 description 1
- OFEAFLZBSTWWRY-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-7-(3-amino-3-methylazetidin-1-yl)-8-chloro-6-fluoro-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2c(Cl)c(N3CC(C)(N)C3)c(F)cc2c1=O OFEAFLZBSTWWRY-UHFFFAOYSA-N 0.000 description 1
- LKZITFQHBQQYBD-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-8-bromo-6-fluoro-4-oxo-7-[3-(propan-2-ylamino)azetidin-1-yl]quinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2c(Br)c(N3CC(C3)NC(C)C)c(F)cc2c1=O LKZITFQHBQQYBD-UHFFFAOYSA-N 0.000 description 1
- ILDPHCSWMSCJOK-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-8-bromo-6-fluoro-7-[3-methyl-3-(methylamino)azetidin-1-yl]-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2c(Br)c(N3CC(C)(C3)NC)c(F)cc2c1=O ILDPHCSWMSCJOK-UHFFFAOYSA-N 0.000 description 1
- IEGRQGATUDBEMQ-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-8-chloro-6-fluoro-4-oxo-7-(3-pyrazol-1-ylazetidin-1-yl)quinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2c(Cl)c(N3CC(C3)n3cccn3)c(F)cc2c1=O IEGRQGATUDBEMQ-UHFFFAOYSA-N 0.000 description 1
- GNKQYJWPDFKDHJ-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-8-chloro-6-fluoro-4-oxo-7-[3-(propan-2-ylamino)azetidin-1-yl]quinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2c(Cl)c(N3CC(C3)NC(C)C)c(F)cc2c1=O GNKQYJWPDFKDHJ-UHFFFAOYSA-N 0.000 description 1
- XAECTMHVNWRJRN-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-8-chloro-6-fluoro-7-(methylamino)-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2c(Cl)c(NC)c(F)cc2c1=O XAECTMHVNWRJRN-UHFFFAOYSA-N 0.000 description 1
- INDSVEABLMEDLL-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-8-chloro-6-fluoro-7-[3-(oxan-4-ylamino)azetidin-1-yl]-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2c(Cl)c(N3CC(C3)NC3CCOCC3)c(F)cc2c1=O INDSVEABLMEDLL-UHFFFAOYSA-N 0.000 description 1
- VFHYBQBQZJCZLM-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-8-chloro-6-fluoro-7-[3-methyl-3-(methylamino)azetidin-1-yl]-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2COC(C)=O)c2c(Cl)c(N3CC(C)(C3)NC)c(F)cc2c1=O VFHYBQBQZJCZLM-UHFFFAOYSA-N 0.000 description 1
- VWSUUACBOBTRIO-UHFFFAOYSA-N ethyl 1-[2-(acetyloxymethyl)-5-amino-4-fluorophenyl]-8-chloro-7-(ethylamino)-6-fluoro-4-oxoquinoline-3-carboxylate Chemical compound CCNc1c(F)cc2c(c1Cl)n(cc(C(=O)OCC)c2=O)-c1cc(N)c(F)cc1COC(C)=O VWSUUACBOBTRIO-UHFFFAOYSA-N 0.000 description 1
- NEPOVDRJIHGCJR-UHFFFAOYSA-N ethyl 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-5-bromo-6-fluoro-7-(3-hydroxyazetidin-1-yl)-8-methyl-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2CO)c2c(C)c(N3CC(O)C3)c(F)c(Br)c2c1=O NEPOVDRJIHGCJR-UHFFFAOYSA-N 0.000 description 1
- LEKOTQPNXJVATQ-UHFFFAOYSA-N ethyl 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-7-(3-aminopyrrolidin-1-yl)-8-chloro-6-fluoro-5-methyl-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2CO)c2c(Cl)c(N3CCC(N)C3)c(F)c(C)c2c1=O LEKOTQPNXJVATQ-UHFFFAOYSA-N 0.000 description 1
- IJIOTMGGXVYUTB-UHFFFAOYSA-N ethyl 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-bromo-6-fluoro-5-methyl-7-[3-(methylamino)azetidin-1-yl]-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2CO)c2c(Br)c(N3CC(C3)NC)c(F)c(C)c2c1=O IJIOTMGGXVYUTB-UHFFFAOYSA-N 0.000 description 1
- ZEWCNWTXKGDNFH-UHFFFAOYSA-N ethyl 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-bromo-6-fluoro-7-(3-hydroxyazetidin-1-yl)-5-methyl-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2CO)c2c(Br)c(N3CC(O)C3)c(F)c(C)c2c1=O ZEWCNWTXKGDNFH-UHFFFAOYSA-N 0.000 description 1
- MHFXLZGCVKZQLS-UHFFFAOYSA-N ethyl 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-chloro-6-fluoro-5-methyl-7-[3-(methylamino)azetidin-1-yl]-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2CO)c2c(Cl)c(N3CC(C3)NC)c(F)c(C)c2c1=O MHFXLZGCVKZQLS-UHFFFAOYSA-N 0.000 description 1
- IIWWVJVCBOKHRV-UHFFFAOYSA-N ethyl 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-5-methyl-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2CO)c2c(Cl)c(N3CC(O)C3)c(F)c(C)c2c1=O IIWWVJVCBOKHRV-UHFFFAOYSA-N 0.000 description 1
- FHJBBVJUGQDJGA-UHFFFAOYSA-N ethyl 1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-chloro-7-[3-(ethylamino)azetidin-1-yl]-6-fluoro-5-methyl-4-oxoquinoline-3-carboxylate Chemical compound CCNC1CN(C1)c1c(F)c(C)c2c(c1Cl)n(cc(C(=O)OCC)c2=O)-c1cc(N)c(F)cc1CO FHJBBVJUGQDJGA-UHFFFAOYSA-N 0.000 description 1
- FRNMYHDKDKUGNK-UHFFFAOYSA-N ethyl 2-(2,5-difluoro-3-methyl-4-nitrobenzoyl)-3-ethoxyprop-2-enoate Chemical compound CCOC=C(C(=O)OCC)C(=O)C1=CC(F)=C([N+]([O-])=O)C(C)=C1F FRNMYHDKDKUGNK-UHFFFAOYSA-N 0.000 description 1
- OQSIKAFYTWBRJG-UHFFFAOYSA-N ethyl 2-(3-bromo-2,4,5-trifluoro-6-methylbenzoyl)-3-ethoxyprop-2-enoate Chemical compound BrC=1C(=C(C(=O)C(C(=O)OCC)=COCC)C(=C(C=1F)F)C)F OQSIKAFYTWBRJG-UHFFFAOYSA-N 0.000 description 1
- SWZVGWDMALRZMD-UHFFFAOYSA-N ethyl 3-(3-bromo-2,4,5-trifluorophenyl)-3-oxopropanoate Chemical compound CCOC(=O)CC(=O)C1=CC(F)=C(F)C(Br)=C1F SWZVGWDMALRZMD-UHFFFAOYSA-N 0.000 description 1
- LZMXLCPYJNRWNQ-UHFFFAOYSA-N ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate Chemical compound CCOC(=O)CC(=O)C1=CC(F)=C(F)C(Cl)=C1F LZMXLCPYJNRWNQ-UHFFFAOYSA-N 0.000 description 1
- UPMFDOIEEUTSQC-UHFFFAOYSA-N ethyl 3-chloro-2,4,5-trifluorobenzoate Chemical compound CCOC(=O)C1=CC(F)=C(F)C(Cl)=C1F UPMFDOIEEUTSQC-UHFFFAOYSA-N 0.000 description 1
- ZIMIAPVHHUISPY-UHFFFAOYSA-N ethyl 3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)prop-2-enoate Chemical compound CCOC=C(C(=O)OCC)C(=O)C1=CC(F)=C(F)C(OC)=C1F ZIMIAPVHHUISPY-UHFFFAOYSA-N 0.000 description 1
- KWDVJYLIAJHEOW-UHFFFAOYSA-N ethyl 3-oxo-3-(2,3,4,5-tetrafluorophenyl)propanoate Chemical compound CCOC(=O)CC(=O)C1=CC(F)=C(F)C(F)=C1F KWDVJYLIAJHEOW-UHFFFAOYSA-N 0.000 description 1
- ILRFWLCVHFWRBD-UHFFFAOYSA-N ethyl 5-amino-1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2CO)c2c(Cl)c(N3CC(O)C3)c(F)c(N)c2c1=O ILRFWLCVHFWRBD-UHFFFAOYSA-N 0.000 description 1
- ATHQUZNMVAQPSD-UHFFFAOYSA-N ethyl 5-amino-1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-chloro-6-fluoro-7-[3-(methylamino)azetidin-1-yl]-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2CO)c2c(Cl)c(N3CC(C3)NC)c(F)c(N)c2c1=O ATHQUZNMVAQPSD-UHFFFAOYSA-N 0.000 description 1
- PGGSNCAOGRGRAO-UHFFFAOYSA-N ethyl 5-amino-7-(3-aminoazetidin-1-yl)-1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-chloro-6-fluoro-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2CO)c2c(Cl)c(N3CC(N)C3)c(F)c(N)c2c1=O PGGSNCAOGRGRAO-UHFFFAOYSA-N 0.000 description 1
- YPDDUVLTNPUAIE-UHFFFAOYSA-N ethyl 5-methyl-4-oxo-1h-quinoline-3-carboxylate Chemical compound C1=CC(C)=C2C(=O)C(C(=O)OCC)=CNC2=C1 YPDDUVLTNPUAIE-UHFFFAOYSA-N 0.000 description 1
- ANFPAKCARLFZQX-UHFFFAOYSA-N ethyl 6,7,8-trifluoro-1-[4-fluoro-2-(hydroxymethyl)phenyl]-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2ccc(F)cc2CO)c2c(F)c(F)c(F)cc2c1=O ANFPAKCARLFZQX-UHFFFAOYSA-N 0.000 description 1
- XXARQBJLMSIFGX-UHFFFAOYSA-N ethyl 6-fluoro-1-[4-fluoro-2-(hydroxymethyl)-5-nitrophenyl]-8-methyl-7-nitro-4-oxoquinoline-3-carboxylate Chemical compound FC=1C=C2C(C(=CN(C2=C(C=1[N+](=O)[O-])C)C1=C(C=C(C(=C1)[N+](=O)[O-])F)CO)C(=O)OCC)=O XXARQBJLMSIFGX-UHFFFAOYSA-N 0.000 description 1
- LNPRCADPRULVTR-UHFFFAOYSA-N ethyl 6-fluoro-4-oxo-1h-quinoline-3-carboxylate Chemical compound C1=C(F)C=C2C(=O)C(C(=O)OCC)=CNC2=C1 LNPRCADPRULVTR-UHFFFAOYSA-N 0.000 description 1
- FBONVQQDYPYNMF-UHFFFAOYSA-N ethyl 7-(3-aminoazetidin-1-yl)-1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-bromo-6-fluoro-5-methyl-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2CO)c2c(Br)c(N3CC(N)C3)c(F)c(C)c2c1=O FBONVQQDYPYNMF-UHFFFAOYSA-N 0.000 description 1
- JSQVGZSKEMCKGU-UHFFFAOYSA-N ethyl 7-(3-aminoazetidin-1-yl)-1-[5-amino-4-fluoro-2-(hydroxymethyl)phenyl]-8-chloro-6-fluoro-5-methyl-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(N)c(F)cc2CO)c2c(Cl)c(N3CC(N)C3)c(F)c(C)c2c1=O JSQVGZSKEMCKGU-UHFFFAOYSA-N 0.000 description 1
- MRLMWMNAMYIEFC-UHFFFAOYSA-N ethyl 8-chloro-1-[5-[(2,4-dimethoxyphenyl)methylamino]-4-fluoro-2-(hydroxymethyl)phenyl]-6-fluoro-7-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]-4-oxoquinoline-3-carboxylate Chemical compound CCOC(=O)c1cn(-c2cc(NCc3ccc(OC)cc3OC)c(F)cc2CO)c2c(Cl)c(CNC(=O)OC(C)(C)C)c(F)cc2c1=O MRLMWMNAMYIEFC-UHFFFAOYSA-N 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- OTTDACPMYLDVTL-UHFFFAOYSA-N ethyl quinoline-3-carboxylate Chemical compound C1=CC=CC2=CC(C(=O)OCC)=CN=C21 OTTDACPMYLDVTL-UHFFFAOYSA-N 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 125000000268 heptanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000003104 hexanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000006038 hexenyl group Chemical group 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 125000006316 iso-butyl amino group Chemical group [H]N(*)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- LSACYLWPPQLVSM-UHFFFAOYSA-N isobutyric acid anhydride Chemical compound CC(C)C(=O)OC(=O)C(C)C LSACYLWPPQLVSM-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 150000007517 lewis acids Chemical class 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910001512 metal fluoride Inorganic materials 0.000 description 1
- 150000004681 metal hydrides Chemical class 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- IHFZUIBTENSHSH-UHFFFAOYSA-N n,n-dimethoxy-1-phenylmethanamine Chemical compound CON(OC)CC1=CC=CC=C1 IHFZUIBTENSHSH-UHFFFAOYSA-N 0.000 description 1
- SOXVXKUTVVNZLA-UHFFFAOYSA-N n,n-dimethylaniline;1-methylpiperidine Chemical compound CN1CCCCC1.CN(C)C1=CC=CC=C1 SOXVXKUTVVNZLA-UHFFFAOYSA-N 0.000 description 1
- RWIVICVCHVMHMU-UHFFFAOYSA-N n-aminoethylmorpholine Chemical compound NCCN1CCOCC1 RWIVICVCHVMHMU-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- QLBGCEBVDMZPPN-UHFFFAOYSA-N n-ethylazetidin-3-amine Chemical compound CCNC1CNC1 QLBGCEBVDMZPPN-UHFFFAOYSA-N 0.000 description 1
- KAHVZNKZQFSBFW-UHFFFAOYSA-N n-methyl-n-trimethylsilylmethanamine Chemical compound CN(C)[Si](C)(C)C KAHVZNKZQFSBFW-UHFFFAOYSA-N 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- NZAFKIPALSGOGK-UHFFFAOYSA-N n-propylazetidin-3-amine Chemical compound CCCNC1CNC1 NZAFKIPALSGOGK-UHFFFAOYSA-N 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- 125000001038 naphthoyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 229960001180 norfloxacin Drugs 0.000 description 1
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 description 1
- 229960001699 ofloxacin Drugs 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 150000002895 organic esters Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- JMJRYTGVHCAYCT-UHFFFAOYSA-N oxan-4-one Chemical compound O=C1CCOCC1 JMJRYTGVHCAYCT-UHFFFAOYSA-N 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 125000002255 pentenyl group Chemical group C(=CCCC)* 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 125000005633 phthalidyl group Chemical group 0.000 description 1
- 229960003506 piperazine hexahydrate Drugs 0.000 description 1
- AVRVZRUEXIEGMP-UHFFFAOYSA-N piperazine;hexahydrate Chemical compound O.O.O.O.O.O.C1CNCCN1 AVRVZRUEXIEGMP-UHFFFAOYSA-N 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 1
- 229910000105 potassium hydride Inorganic materials 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- SPQTUOKWIUXZDB-UHFFFAOYSA-N propanoyl 2,2-dimethylpropanoate Chemical compound CCC(=O)OC(=O)C(C)(C)C SPQTUOKWIUXZDB-UHFFFAOYSA-N 0.000 description 1
- 125000001325 propanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000005767 propoxymethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])[#8]C([H])([H])* 0.000 description 1
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000006462 rearrangement reaction Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- XGVXKJKTISMIOW-ZDUSSCGKSA-N simurosertib Chemical compound N1N=CC(C=2SC=3C(=O)NC(=NC=3C=2)[C@H]2N3CCC(CC3)C2)=C1C XGVXKJKTISMIOW-ZDUSSCGKSA-N 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- LKTBVNSJVPWOKC-UHFFFAOYSA-N tert-butyl 1,6-diazaspiro[3.3]heptane-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC11CNC1 LKTBVNSJVPWOKC-UHFFFAOYSA-N 0.000 description 1
- KVOUHLVOTMOJBS-UHFFFAOYSA-N tert-butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CC11CNC1 KVOUHLVOTMOJBS-UHFFFAOYSA-N 0.000 description 1
- XRRXRQJQQKMFBC-UHFFFAOYSA-N tert-butyl 3-hydroxyazetidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CC(O)C1 XRRXRQJQQKMFBC-UHFFFAOYSA-N 0.000 description 1
- APCBTRDHCDOPNY-UHFFFAOYSA-N tert-butyl 3-hydroxypyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(O)C1 APCBTRDHCDOPNY-UHFFFAOYSA-N 0.000 description 1
- 125000006318 tert-butyl amino group Chemical group [H]N(*)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- GMRIOAVKKGNMMV-UHFFFAOYSA-N tetrabutylazanium;azide Chemical compound [N-]=[N+]=[N-].CCCC[N+](CCCC)(CCCC)CCCC GMRIOAVKKGNMMV-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229950008187 tosufloxacin Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- JABYJIQOLGWMQW-UHFFFAOYSA-N undec-4-ene Chemical compound CCCCCCC=CCCC JABYJIQOLGWMQW-UHFFFAOYSA-N 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Definitions
- the present invention relates to a novel pyridonecarboxylic acid derivative having an excellent antibacterial action or a salt thereof.
- Non-Patent Documents 1 and 2 the existence of many resistant bacteria to these quinolone antibacterial agents has been reported and has become a clinical problem.
- Non-Patent Documents 3 to 4 resistance to methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa tends to increase (Non-Patent Documents 3 to 4).
- antibacterial-related diarrhea caused by quinolone-resistant Clostridium difficile has become a problem as a result of disturbing the intestinal flora by administration of quinolone antibacterial agents (Non-Patent Documents 5 to 6).
- Non-patent Document 7 The mechanism of drug resistance of various bacteria against such quinolone antibacterial agents is to reduce the affinity due to mutation of the target molecule type II topoisomerase (DNA gyrase) or to release the drug out of the cell by a drug efflux pump. It has been reported that the action of a drug is reduced by pumping out (Non-patent Document 7). Therefore, it is desired to develop a derivative that is effective against DNA gyrase mutation and a drug that is not easily affected by the drug discharge pump (Non-patent Document 8).
- Patent Document 6 methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa that are resistant to this are also confirmed in the derivatives, and there is a problem that sufficient effects cannot be obtained.
- the present invention relates to providing a novel pyridonecarboxylic acid derivative or a salt thereof having an excellent effect on bacteria such as methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Clostridium difficile.
- the present inventors have intensively studied to obtain a compound that can be a clinically superior synthetic antibacterial agent.
- the compound represented by the following formula (1) is methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, It has been found that it has an excellent antibacterial activity against bacteria such as Clostridium difficile and is hardly affected by Pseudomonas aeruginosa by a drug evacuation pump.
- R 1 represents a hydrogen atom, a halogen atom, a lower alkyl group or an amino group
- R 2 represents a group —NH—R 6 (wherein R 6 represents a hydrogen atom, a lower alkyl group, an amino lower alkyl group, A hydroxy lower alkyl group, a dimethylamino lower alkyl group, a lower alkoxy lower alkyl group, a morpholino lower alkyl group, or an aralkyl group optionally having substituent (s)), a group —O—R 7 (where R 7 represents a hydrogen atom, a lower alkyl group, an azetidin-3-yl group which may have a substituent, or a pyrrolidin-3-yl group which may have a substituent.
- R 8 represents an amino group, a lower alkylamino group, a cyclic amino group, a hydroxyl group, or a lower alkoxy group, and m represents an integer of 1 to 4) or the following formula ( 2):
- Y is NH or C—R 9a R 9b (where R 9a and R 9b are each independently a hydrogen atom, a lower alkyl group, an amino group, a lower alkylamino group, N-methyl-N— ( 5-methyl-2-oxo-1,3-dioxol-4-yl) methylamino group, hydroxy lower alkylamino group, lower alkyl hydrazino group, tetrahydropyran-4-ylamino group, pyrazol-1-yl group, dimethyl
- An amino lower alkyl group or a hydroxyl group, R 9a and R 9b may be combined with an adjacent carbon atom to form a nitrogen-containing saturated heterocyclic ring, and n and p are integers of 1 or 2; Is shown.
- R 3 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group
- R 4 represents a hydrogen atom or a carboxyl
- R 1 is a hydrogen atom, a methyl group, a bromine atom or an amino group
- R 2 is a cyclic amino group represented by the formula (2), or a pyridonecarboxylic acid derivative of any one of 1) to 4) Its salt.
- 6) The pyridonecarboxylic acid derivative or salt thereof according to 5), wherein Y is C—R 9a R 9b and n and p are 1 in formula (2).
- R 4 is a hydrogen atom or a protecting group that is easily eliminated in vivo
- R 5 is a hydrogen atom or a protecting group that is easily eliminated in vivo.
- Acid derivative or salt thereof 9)
- An antibacterial agent comprising the pyridonecarboxylic acid derivative or salt thereof according to any one of 1) to 8) as an active ingredient.
- An antibacterial composition comprising the pyridonecarboxylic acid derivative or salt thereof according to any one of 1) to 8) and a pharmaceutically acceptable carrier.
- the pyridonecarboxylic acid derivative of the present invention or a salt thereof has an excellent antibacterial action against bacteria such as methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, Clostridium difficile, and a drug efflux pump against Pseudomonas aeruginosa. Not easily affected. Therefore, it can be widely applied to the treatment of infectious diseases including the bacteria.
- the term “lower” means that the hydrocarbon moiety of the group to which the term is attached has 1 to 7 carbon atoms (abbreviated as “C 1-7 ”).
- the hydrocarbon moiety may be either linear or branched.
- “may have a substituent” means that the hydrogen atom of the target group may be substituted with another group, and the number of the substituent is one or more. And when having two or more substituents, the substituents may be the same or different.
- halogen atom represented by R 1 include a bromine atom, a chlorine atom, a fluorine atom, and iodine, with a bromine atom being preferred.
- the “lower alkyl group” represented by R 1 is preferably a C 1-4 alkyl group such as a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, or a tert-butyl group, and more preferably A C 1-3 alkyl group, more preferably a methyl group.
- the “lower alkyl group” represented by R 6 is preferably a C 1-4 alkyl group, more preferably a C 1-3 alkyl group, a methyl group, an ethyl group Is more preferable.
- amino lower alkyl group represented by R 6 include amino C 1-3 alkyl groups such as 2-aminoethyl group and 3-aminopropyl group.
- dimethylamino lower alkyl group represented by R 6 include dimethylamino C 1-4 alkyl groups such as 3-dimethylaminopropyl group and 2-dimethylaminoethyl group.
- lower alkoxy lower alkyl group for R 6 include C 1-3 alkoxy C 1-4 alkyl groups such as methoxyethyl group and 3-methoxypropyl group.
- Preferred examples of the “morpholino lower alkyl group” for R 6 include morpholino C 1-4 alkyl groups such as 2-morpholinoethyl group and 3-morpholinopropyl group.
- the “aralkyl group” in the “aralkyl group optionally having substituent (s)” represented by R 6 is C 7-14 aralkyl group, preferably C 6-12 aryl such as benzyl group, phenethyl group, benzhydryl group and the like. -C 1-2 alkyl group may be mentioned.
- examples of the aralkyl group having a substituent include an aralkyl group in which the aryl moiety is substituted by 1 to 3 by a methoxy group, a hydroxy group, an amino group, a carboxy group, etc., and a 2,4-dimethoxybenzyl group is preferable. It is done.
- R 6 includes a C 1-4 alkyl group, more preferably a methyl group and an ethyl group.
- the “lower alkyl group” represented by R 7 is preferably a C 1-4 alkyl group, more preferably a C 1-3 alkyl group, a methyl group, an ethyl group Is more preferable.
- Examples of the substituent in the “optionally substituted azetidin-3-yl group” and the “optionally substituted pyrrolidin-3-yl group” represented by R 7 include, for example, C 1- 3 alkyl group and the like can be mentioned.
- Preferred examples of the substituent include azetidin-3-yl group, 1-methylazetidin-3-yl group, pyrrolidin-3-yl group, and 1-methylpyrrolidin-3-yl group.
- R 2 - (CH 2) in m -R 8 as the "lower alkylamino group" represented by R 8, for example, an C 1-4 alkylamino group, these C 1-3 alkyl
- An amino group is preferable, and an ethylamino group, a methylamino group, and the like are more preferable.
- the “lower alkoxy group” represented by R 8 is preferably a C 1-4 alkoxy group such as a methoxy group, an ethoxy group, a propoxy group, or a butoxy group, more preferably a C 1-3 alkoxy group, still more preferably It is a methoxy group.
- R 8 includes an amino group, a methylamino group, an azetidinyl group, a hydroxyl group and the like, more preferably an amino group, and preferable m is 1 to 2.
- examples of the “lower alkyl group” represented by R 9a and R 9b include a methyl group, ethyl group, propyl C 1-4 alkyl groups such as a group, isopropyl group, butyl group, isobutyl group, tert-butyl group, etc., among which a C 1-3 alkyl group is preferred, and a methyl group is more preferred.
- Examples of the “lower alkylamino group” represented by R 9a and R 9b include C, such as methylamino group, ethylamino group, propylamino group, isopropylamino group, butylamino group, isobutylamino group, and tert-butylamino group.
- a 1-4 alkylamino group is mentioned, Among these, a C1-3 alkylamino group is preferable, More preferably, a methylamino group and an ethylamino group are mentioned.
- Examples of the “hydroxy lower alkylamino group” represented by R 9a and R 9b include a hydroxy C 1-4 alkylamino group, of which a hydroxy C 1-3 alkylamino group is preferable, and a 2-hydroxy hydroxy group is more preferable. Examples include an ethylamino group and a 1-hydroxyisopropylamino group.
- dimethylamino lower alkyl group represented by R 9a and R 9b include dimethylamino C 1-4 alkyl groups such as dimethylaminomethyl group, 3-dimethylaminopropyl group, 2-dimethylaminoethyl group and the like. It is done.
- Examples of the “lower alkyl hydrazino group” represented by R 9a and R 9b include C 1-3 alkyl hydrazino groups such as methyl hydrazino group, ethyl hydrazino group, propyl hydrazino group and isopropyl hydrazino group. Of these, 2-methylhydrazino group and 2-ethylhydrazino group are more preferable.
- the nitrogen-containing saturated heterocyclic ring formed by combining R 9a and R 9b with adjacent carbon atoms is preferably a 3- to 6-membered nitrogen-containing saturated heterocyclic ring containing at least one nitrogen atom, Preferably, azetidine etc. are mentioned.
- the cyclic amino group represented by the formula (2) is preferably a 3-aminoazetidin-1-yl group, a 3-hydroxyazetidin-1-yl group, a 3-C 1-4 alkylaminoazetidine- 1-yl group (for example, 3-methylaminoazetidin-1-yl group, 3-ethylaminoazetidin-1-yl group, 3-isopropylaminoazetidin-1-yl group), 3- (tetrahydropyran -4-yl) aminoazetidin-1-yl group, 3-amino-3-methylazetidin-1-yl group, 3- (NC 1-4 alkyl-N- (5-methyl-2-oxo) -1,3-dioxol-4-yl) methylamino) azetidin-1-yl group (eg, 3- (N-methyl-N- (5-methyl-2-oxo-1,3-dioxol-4-y
- a 3-C 1-4 alkylaminoazetidin-1-yl group is more preferred, and a 3-methylaminoazetidin-1-yl group and a 3-ethylaminoazetidin-1-yl group are still more preferred.
- halogen atom represented by R 3
- examples of the “halogen atom” represented by R 3 include a bromine atom, a chlorine atom, a fluorine atom, and iodine, with a bromine atom and a chlorine atom being preferred.
- the “lower alkyl group” represented by R 3 is preferably a C 1-4 alkyl group such as methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, tert-butyl group, more preferably C It is a 1-3 alkyl group, more preferably a methyl group.
- the “lower alkoxy group” represented by R 3 is preferably a C 1-4 alkoxy group such as a methoxy group, an ethoxy group, a propoxy group, or a butoxy group, more preferably a C 1-3 alkoxy group, still more preferably. It is a methoxy group.
- R 3 includes a chlorine atom, a bromine atom, and a methyl group.
- the carboxyl group-protecting group represented by R 4 refers to an ester residue of a carboxylic acid ester, and includes any that can be cleaved relatively easily to generate a corresponding free carboxyl group.
- C 1-7 such as methyl group, ethyl group, n-propyl group, 2-propyl group, n-butyl group, i-butyl group, t-butyl group, pentyl group, hexyl group, heptyl group, etc.
- Alkyl group vinyl group, allyl group, 1-propenyl group, butenyl group, pentenyl group, hexenyl group, heptenyl group and other C 2-7 alkenyl groups; benzyl group and other aralkyl groups; phenyl group and naphthyl group and other aryl groups That are eliminated by treatment under mild conditions such as hydrolysis and catalytic reduction, etc., or C 2-7 alkanoyloxy C 1-4 lower alkyl groups such as acetoxymethyl group and pivaloyloxymethyl group; C 1-4 alkoxycarbonyloxy C 1-4 alkyl group such as carbonyloxymethyl group and 1-ethoxycarbonyloxyethyl group; C 1-4 alkoxymethyl group such as methoxymethyl group ; Di C 1-4 alkylamino C 1-4 alkyl groups such as 1-dimethylaminoethyl group; phthalidyl Rakutoniru group such as (5-methyl-2
- the hydroxyl-protecting group represented by R 5 includes any group that can be cleaved relatively easily to generate a corresponding free hydroxyl group.
- C 1-8 alkanoyl groups such as formyl group, acetyl group, n-propanoyl group, n-butanoyl group, 2-butanoyl group, pentanoyl group, hexanoyl group and heptanoyl group; benzoyl group, naphthoyl group and the like
- Aromatic carbonyl group aromatic methylcarbonyl group such as benzylcarbonyl group and naphthylmethylcarbonyl group
- C 1 such as methoxycarbonyl group, ethoxycarbonyl group, n-propoxycarbonyl group, 2-propoxycarbonyl group and n-butoxycarbonyl group -7 alkyloxycarbonyl group
- C 1-4 lower alkoxymethyl group such as methoxymethyl group, ethoxymethyl group
- R 1 is a hydrogen atom, a halogen atom (preferably a bromine atom) or a C 1-4 alkyl group (preferably a methyl group), and R 2 is a cyclic amino represented by the formula (2)
- a group preferably Y is C—R 9a R 9b , more preferably R 9a is a hydrogen atom, R 9b is a C 1-4 alkylamino group (preferably a methylamino group or an ethylamino group), and n and p are It is more preferable that R 4 is a hydrogen atom or a protecting group that is easily eliminated in vivo, and R 5 is a hydrogen atom or a protecting group that is easily eliminated in vivo.
- the pyridonecarboxylic acid derivative of the present invention can form both acid addition salts and base addition salts.
- This salt includes those formed with a chelate salt with a boron compound.
- acid addition salts include (A) salts with mineral acids such as hydrochloric acid and sulfuric acid, (B) salts with organic carboxylic acids such as formic acid, citric acid, trichloroacetic acid, trifluoroacetic acid, fumaric acid and maleic acid, (C) Salts with sulfonic acids such as methane sulfonic acid, benzene sulfonic acid, p-toluene sulfonic acid, mesitylene sulfonic acid, naphthalene sulfonic acid, etc.
- Examples of base addition salts include (A ′) sodium, potassium, etc. (B ′) salts with alkaline earth metals such as calcium and magnesium, (C ′) ammonium salts, (D ′) trimethylamine, triethylamine, tributylamine, pyridine, N, N-dimethylaniline N-methylpiperidine, N-methylmorpholine, diethylamine, cyclohexylamine, procaine, dibenzylamino , N- benzyl - ⁇ - phenethylamine, 1-Efenamin, N, N'- dibenzylethylenediamine, may be mentioned salts with nitrogen-containing organic bases such as N- methylglucamine.
- Examples of the boron compound include boron halides such as boron fluoride and lower acyloxyborons such as acetoxyboron.
- the pyridonecarboxylic acid derivative or a salt thereof can exist not only as an unsolvated form but also as a hydrate or a solvate. Accordingly, the compounds of the present invention include all crystal forms and hydrates or solvates thereof.
- the pyridonecarboxylic acid derivative or a salt thereof can exist as an optically active substance. These optically active substances are also included in the compound of the present invention. Furthermore, the pyridonecarboxylic acid derivative of the present invention or a salt thereof may exist as different stereoisomers (cis type, trans type). These stereoisomers are also included in the present invention.
- the pyridonecarboxylic acid derivative of the present invention or a salt thereof is produced by an arbitrary method depending on the type of substituent and the like, and examples thereof are as follows.
- R 1a represents a hydrogen atom, a halogen atom or a lower alkyl group
- R 10 represents a lower alkyl group, a lower alkenyl group or an aralkyl group
- R 11 , R 12 and R 13 each represent a lower alkyl group.
- R 14 represents a lower alkanoyl group
- L 1 represents a halogen atom
- L 2 represents a halogen atom, a nitro group or an amino group
- R 3 represents the same as described above.
- the compound (I) is obtained by adding a malonic acid ester to the compound (II) and then reacting the orthoformate (a) such as ethyl orthoformate or methyl orthoformate.
- the resulting compound is reacted with aniline compound (b) to obtain compound (III).
- this is subjected to a cyclization reaction, and the resulting compound (IV) is nitrated and then re-esterified as necessary to give compound (V), which is reduced to give compound (VI) or Compound (1A) is obtained.
- the “lower alkyl group” represented by R 10 is preferably a C 1-4 alkyl group, and more preferably a methyl group, an ethyl group, or a t-butyl group.
- the “lower alkenyl group” is preferably a C 2-4 alkenyl group, more preferably a vinyl group, an allyl group, a 1-propenyl group or the like.
- the “aralkyl group” is preferably a C 7-14 aralkyl group, more preferably a benzyl group, a phenethyl group, a benzhydryl group, or the like.
- the “lower alkyl group” represented by R 11 , R 12 and R 13 is preferably a C 1-3 alkyl group, more preferably an ethyl group.
- the “lower alkanoyl group” represented by R 14 is preferably a C 1-7 alkanoyl group, and preferably an acetyl group, a propionyl group, a butyryl group, a valeryl group and the like.
- the halogen atom represented by L 1 and L 2 is preferably a chlorine atom or a fluorine atom.
- the carbon increase reaction of compound (I) is usually performed by activating compound (I) with oxalyl dichloride, thionyl chloride or carbonyldiimidazole, and then in the presence of a base such as malonic acid diester or ethyl potassium malonate. After adding malonic acid monoester, decarboxylation is performed.
- the reaction in the activation is usually carried out at 0 to 150 ° C., preferably 0 to 100 ° C.
- the reaction time is usually 10 minutes to 48 hours, preferably 1 to 10 hours
- the addition reaction is usually 0 to 150 ° C.
- the reaction time is usually 10 minutes to 48 hours, preferably 1 to 10 hours.
- the reaction of compound (II) with orthoformate ester (a) is usually carried out at 0 to 160 ° C., preferably 50 to 150 ° C., and the reaction time is usually 10 minutes to 48 hours, preferably 1 to 10 It's time.
- the amount of orthoformate used is preferably an equimolar amount or more, particularly about 1 to 10 times the molar amount relative to compound (I).
- the reaction with the aniline compound (b) is carried out in a suitable reaction solvent.
- the solvent used here may be any as long as it does not affect the reaction.
- aromatic hydrocarbons such as toluene and xylene, ethers such as diethyl ether, tetrahydrofuran and dioxane, pentane and hexane.
- Aliphatic hydrocarbons such as methylene chloride, chloroform, carbon tetrachloride, aprotic polar solvents such as dimethylformamide, dimethyl sulfoxide, N-methylpyrrolidin-2-one, methanol, ethanol, Examples thereof include alcohols such as propanol.
- This reaction is usually carried out at 0 to 150 ° C., preferably 0 to 100 ° C., and the reaction time is usually 10 minutes to 48 hours, preferably 1 to 10 hours.
- the basic compounds used include alkali metals such as metal sodium and metal potassium, metal hydrides such as sodium hydride and calcium hydride, sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate.
- Inorganic bases such as sodium methoxide, sodium ethoxide, alkoxides such as potassium tert-butoxide, metal fluorides such as sodium fluoride and potassium fluoride, triethylamine, 1,8-diazabicyclo [5.4 .0] undec-7-ene (DBU) and the like.
- This reaction is usually carried out at 0 to 200 ° C., preferably room temperature to 100 ° C., and the reaction time is usually completed in 10 minutes to 48 hours.
- nitration of compound (IV) a general method used for aromatic compounds is used.
- the nitrating agent include nitric acid or a mixed acid in which nitrate and sulfuric acid are combined.
- the reaction temperature is preferably ⁇ 10 ° C. to 80 ° C., and the reaction time is preferably 5 minutes to 24 hours.
- the hydroxyl group may be converted to an acid ester depending on the acid used in the reaction, and in that case, lower alkylcarbonylation is required subsequently.
- This reaction is carried out using a common organic acid for the resulting intermediate alcoholic acid ester.
- the acid used formic acid, acetic acid, propionic acid and the like are used, and acetic acid is preferably used.
- This reaction is usually carried out at 0 to 150 ° C., preferably room temperature to 100 ° C., and the reaction time is usually completed in 10 minutes to 48 hours.
- carboxylic acid may be obtained with hydrolysis of R 10 .
- lower alkyl esterification is performed again.
- the esterification method is carried out using the corresponding lower alcohol via an acid chloride obtained using thionyl chloride or oxalyl dichloride.
- the reaction temperature for obtaining the acid chloride is usually ⁇ 10 ° C. to 150 ° C., preferably 0 ° C.
- reaction time is usually 10 minutes to 48 hours, preferably 1 to 10 hours.
- the reaction with the alcohol is usually carried out at 0 ° C. to 150 ° C., preferably 0 ° C. to 100 ° C., and the reaction time is usually 10 minutes to 48 hours, preferably 1 to 10 hours.
- a commonly used method can be applied to the reduction reaction for the compound (V).
- reduction using a sulfide such as sodium acid and catalytic reduction using platinum, Raney nickel, platinum-carbon (Pt—C), palladium carbon (Pd—C) and the like.
- R 2a represents a group —NH—R 6 , a group —O—R 7 (R 6 and R 7 are as defined above) or a cyclic amino group represented by the formula (2); 1a , R 3 , R 10 , R 14 and L 2 are the same as described above. ]
- Aromatic substitution reactions include aromatic hydrocarbons such as toluene, xylene and pyridine, ethers such as diethyl ether, tetrahydrofuran and dioxane, aliphatic hydrocarbons such as pentane and hexane, methylene chloride, chloroform and tetrachloride.
- solvents that do not affect the reaction such as halogenated hydrocarbons such as carbon, aprotic polar solvents such as dimethylformamide, N-methylpyrrolidin-2-one, and dimethyl sulfoxide, and alcohols such as methanol, ethanol, and propanol Deoxidizers as required, such as sodium carbonate, calcium carbonate, sodium bicarbonate, potassium carbonate, sodium hydroxide, triethylamine, 1,8-diazabicyclo [5.4.0] undec-7-ene (DBU), Existence of tetramethylguanidine, sodium hydride, etc. Under carried out at room temperature ⁇ 100 ° C.. The reaction time is completed in several minutes to 48 hours.
- halogenated hydrocarbons such as carbon
- aprotic polar solvents such as dimethylformamide, N-methylpyrrolidin-2-one, and dimethyl sulfoxide
- alcohols such as methanol, ethanol, and propanol Deoxidizers as required, such as
- the amount of R 2a —H (compound (c)) used is preferably equimolar to 5-fold molar to the compound (VI).
- this reaction may be performed in the presence of a lithium salt such as lithium chloride as a weak Lewis acid.
- R 2a when R 2a is introduced, an aromatic substitution reaction may be performed using R 2a —H (compound c) having a protecting group.
- R 2a —H compound c
- the dimethoxybenzylamine or t-butoxycarbonylaminopropylamino group when dimethoxybenzylamine or t-butoxycarbonylaminopropylamino group is introduced, the dimethoxybenzyl group and t-butoxycarbonyl group are eliminated by the acidic compound, and the target amino group or aminopropylamino group is introduced.
- the resulting compound is obtained.
- the acidic compound used include inorganic acids such as hydrochloric acid and organic acids such as trifluoroacetic acid. This reaction is usually carried out at 0 to 80 ° C., preferably 0 ° C. to room temperature, and the reaction time is usually completed in 5 minutes to 10 hours.
- a commonly used hydrolysis reaction can be applied.
- the deprotection reaction is performed using an inorganic base such as sodium hydroxide or potassium hydroxide in an alcohol solution. Can do. This reaction is usually carried out at 0 to 150 ° C., preferably at room temperature to 100 ° C., and the reaction time is usually 10 minutes to 48 hours.
- R 4a represents a carboxyl-protecting group
- R 5a represents a hydroxyl-protecting group
- R 1a , R 2a and R 3 represent the same as described above.
- Examples of the carboxyl protecting group represented by R 4a and the hydroxyl protecting group represented by R 5a are the same as those represented by R 4 and R 5 , respectively.
- compound (1E) is obtained by introducing a carboxyl protecting group into compound (1C), and then compound (1F) is obtained by introducing a hydroxyl protecting group.
- compound (1G) is obtained by introducing a hydroxyl protecting group to compound (1C) to give compound (1G).
- a carboxyl protecting group can be introduced into compound (1F).
- a carboxyl protecting group can be achieved by using alkyl halide or 4-halomethyl-5-methyl-2-oxo-1,3-dioxole, acetoxymethyl halide, pivaloyloxymethyl halide, etc. such as toluene, xylene, pyridine, etc.
- Aromatic hydrocarbons such as diethyl ether, tetrahydrofuran and dioxane, aliphatic hydrocarbons such as pentane and hexane, halogenated hydrocarbons such as methylene chloride, chloroform and carbon tetrachloride, dimethylformamide, N-methyl
- a solvent that does not affect the reaction such as an aprotic polar solvent such as pyrrolidin-2-one or dimethyl sulfoxide
- a deoxidizer such as sodium carbonate, calcium carbonate, sodium hydrogen carbonate, potassium carbonate, water is used as necessary.
- DBU 1,8-di Azabicyclo [5.4.0] undec-7-ene
- Hydroxyl protecting groups can be introduced by using phosphorus oxychloride, dialkylchloromethyl phosphate, dibenzylchloromethyl phosphate, etc., ethers such as diethyl ether, tetrahydrofuran, dioxane, aliphatic hydrocarbons such as pentane, hexane, methylene chloride, etc.
- a solvent that does not affect the reaction such as halogenated hydrocarbons such as chloroform and carbon tetrachloride, aprotic polar solvents such as dimethylformamide, N-methylpyrrolidin-2-one, and dimethyl sulfoxide.
- Deoxidizers such as sodium carbonate, calcium carbonate, sodium bicarbonate, potassium carbonate, sodium hydroxide, triethylamine, 1,8-diazabicyclo [5.4.0] undec-7-ene (DBU), tetramethylguanidine, Cooling in the presence of sodium hydride It is carried out at ⁇ 100 °C. The reaction time is completed in several minutes to 48 hours.
- R 15 represents an amino protecting group
- R 1a , R 3 , R 10 , R 11 , R 12 , R 13 , L 1 , and L 2 represent the same as described above.
- the “amino protecting group” represented by R 15 is preferably an aralkyl group such as a benzyl group, a phenethyl group, a benzhydryl group, or a 2,4-dimethoxybenzyl group.
- the reaction between compound (VIII) and orthoformate and the reaction with aniline compound (d ′) can be carried out in the same manner as in step 1-1.
- the cyclization reaction for obtaining the compound (X) can also be performed by the same method as in Step 1-1.
- Removal of the amino protecting group R 15 of the compound (X) is performed by a general deprotection reaction. For example, it is carried out in an appropriate solvent using an acidic compound in the presence of a cation scavenger such as anisole. Any solvent may be used for this reaction as long as it does not affect the reaction.
- aromatic hydrocarbons such as toluene and xylene, ethers such as diethyl ether, tetrahydrofuran and dioxane, pentane, and the like.
- Aliphatic hydrocarbons such as hexane, halogenated hydrocarbons such as methylene chloride, chloroform and carbon tetrachloride, aprotic polar solvents such as dimethylformamide and dimethyl sulfoxide, alcohols such as methanol, ethanol and propanol It is done.
- the acidic compound used include inorganic acids such as hydrochloric acid and organic acids such as trifluoroacetic acid. This reaction is usually carried out at 0 to 80 ° C., preferably 0 ° C. to room temperature, and the reaction time is usually completed in 5 minutes to 10 hours.
- compound (1H) is obtained by aromatic substitution reaction between compound (XI) and R 2a -H (compound (c)), and then the protective group is eliminated by deprotection reaction. .
- compound (XI) can be deprotected to give compound (XII), and a substitution reaction can be conducted to lead to compound (1I).
- compound (1I) is subjected to deprotection reaction in the same manner as described above to remove the protecting group to give compound (XII), and subjected to the same substitution reaction as described above to (1I). It can also be guided.
- R 1a , R 2a , R 3 , R 5a , R 10 represent the same as described above.
- R 1a , R 2a , R 3 , R 4a , R 5a represent the same as described above.
- compound (1K) is obtained by introducing a carboxyl protecting group into compound (1I), and then compound (1L) is obtained by introducing a hydroxyl protecting group.
- the compound (1I) can be introduced into the compound (1L) by introducing a hydroxyl protecting group into the compound (1M) and then introducing a carboxyl protecting group.
- nitration of the compound (I ′) a general method used for aromatic compounds is used.
- the nitrating agent include nitric acid or a mixed acid in which nitrate and sulfuric acid are combined.
- the reaction temperature is preferably ⁇ 10 ° C. to 80 ° C., and the reaction time is preferably 5 minutes to 24 hours.
- step 1- 1 Carbonization reaction of compound (XIII), reaction of compound (XIV) with orthoformates, reaction with aniline (c), and cyclization reaction to obtain compound (XVI) are all in step 1- 1 can be performed.
- a commonly used method can be applied, for example, dissolved metal reduction using zinc, iron, tin, tin chloride, etc. in an acidic solution, sodium sulfide, sodium hydrosulfide, dithione Examples thereof include reduction using a sulfide such as sodium acid, and catalytic reduction using platinum, Raney nickel, platinum-carbon (Pt—C), palladium carbon (Pd—C) and the like.
- a reaction with iron is preferable, and the reaction is usually performed at room temperature to 150 ° C., preferably 50 to 100 ° C., and the reaction time is usually 10 minutes to 48 hours, preferably 1 to 10 hours.
- the deprotection reaction for eliminating R 15 in compound (XVII) can be carried out in the same manner as in Step 2-1.
- compound (1N) is obtained by aromatic substitution reaction between compound (XVIII) and R 2a -H (compound (c)), and then the protective group is eliminated by deprotection reaction to obtain compound (1O).
- R 2a , R 3 , R 5a and R 10 are the same as defined above.
- R 2a , R 3 , R 4a and R 5a represent the same as described above.
- the compound (1Q) is obtained by introducing a carboxyl protecting group into the compound (1O), and then the compound (1R) is obtained by introducing a hydroxyl protecting group.
- the compound (1O) can be introduced into the compound (1R) by introducing a hydroxyl protecting group into the compound (1S) and then introducing a carboxyl group protecting group.
- R 16 represents a lower dialkylamino group
- R 1a , R 2a , R 3 , R 10 , R 11 , R 12 , R 13 , R 15 , L 1 , L 2 are the same as described above. Show. ]
- Aromatic substitution reaction between compound (I ′) and R 2a —H is carried out by aromatic hydrocarbons such as toluene, xylene, pyridine and the like, ethers such as diethyl ether, tetrahydrofuran and dioxane, Deoxidation as necessary in a solvent that does not affect the reaction, such as aliphatic hydrocarbons such as pentane and hexane, aprotic polar solvents such as dimethylformamide, N-methylpyrrolidin-2-one, and dimethylsulfoxide
- aromatic hydrocarbons such as toluene, xylene, pyridine and the like
- ethers such as diethyl ether, tetrahydrofuran and dioxane
- Deoxidation as necessary in a solvent that does not affect the reaction, such as aliphatic hydrocarbons such as pentane and hexane, aprotic polar solvents such as dimethylformamide, N-
- the carbon addition reaction for obtaining the compound (XX) and the reaction of the compound (XX) with the orthoformate ester (a) can be carried out by the same method as that shown in Step 1-1.
- compound (XX) is reacted with acetals (e) such as N, N-dimethylformamide dimethyl acetal, N, N-dimethylformamide diethyl acetal, and then reacted with compound (d ′). It can also lead to compound (XXI).
- the lower dialkylamino group represented by R 16 is a C 1-3 dialkylamino group, and more preferably a dimethylamino group.
- any solvent that does not affect the reaction may be used.
- aromatic hydrocarbons such as toluene and xylene, diethyl ether, tetrahydrofuran, dioxane and the like.
- Ethers aliphatic hydrocarbons such as pentane and hexane, halogenated hydrocarbons such as methylene chloride, chloroform and carbon tetrachloride, aprotic polar solvents such as dimethylformamide and dimethyl sulfoxide, methanol, ethanol and propanol Alcohol etc.
- This reaction is usually carried out at 0 to 150 ° C., preferably at room temperature to 100 ° C., and the reaction time is usually 10 minutes to 48 hours, preferably 1 to 10 hours.
- the cyclization reaction for obtaining the compound (XXII) can be carried out in the same manner as in Step 1-1.
- R 1a , R 2a , R 3 , R 4a , R 5a represent the same as described above.
- a compound (1V) is obtained by introducing a carboxyl protecting group into the compound (1U), and then a compound (1W) is obtained by introducing a hydroxyl protecting group.
- the compound (1U) can be introduced into the compound (1W) by introducing a hydroxyl protecting group into the compound (1X) and then introducing a carboxyl group protecting group.
- R 17 represents a lower alkyl group, a lower alkenyl group or an aralkyl group
- R 18 represents a lower alkyl group
- R 19 represents an amino protecting group
- R 1a , R 3 , R 10 , R 11 , R 12 , R 13 , R 15 , R 16 , L 1 and L 2 are the same as described above.
- reaction is followed by a cyclization reaction, and the compound (1Y) is obtained by removing the amino protecting group R 15 and the amino protecting group R 19 of the resulting compound (XXIX). Further, the compound (1Z) can be obtained by removing the carboxyl protecting group of the compound (1Y).
- the lower alkyl group, lower alkenyl group and aralkyl group represented by R 17 are the same as those represented by R 10 .
- the lower alkyl group represented by R 18 is preferably a C 1-4 alkyl group, more preferably a t-butyl group.
- the amino protecting group represented by R 19 is preferably a benzyloxycarbonyl group, a t-butoxycarbonyl group, an allyloxycarbonyl group, a 2,2,2-trichloroethoxycarbonyl group or the like, more preferably a t-butoxy group. It is a carbonyl group.
- the aromatic substitution reaction between compound (XXIII) and malonic acid diesters is usually carried out by adding malonic acid diesters such as di-t-butyl malonate to compound (XXIII) in the presence of a base. It is carried out by deprotection and decarboxylation.
- a dehydrating agent for example, a metal hydride such as sodium hydride or calcium hydride, if necessary, Inorganic bases such as sodium hydroxide, potassium hydroxide, potassium carbonate, etc., alkoxides such as sodium methoxide, sodium ethoxide, potassium t-butoxide, 1,8-diazabicyclo [5.4.0] undec-
- DBU 7-ene
- the reaction time is completed in several minutes to 48 hours.
- the amount of malonic acid diester used is preferably equimolar to 5-fold molar relative to compound (XXIII).
- (XXIV) is obtained by elimination and decarboxylation of R 18 following the aromatic substitution reaction.
- the elimination reaction of R 18 needs to be performed under conditions that do not remove R 17 .
- acid elimination and decarboxylation reactions are usually performed by aromatic hydrocarbons such as toluene and xylene, ethers such as diethyl ether, tetrahydrofuran and dioxane, and halogenated carbonization such as methylene chloride, chloroform and carbon tetrachloride.
- solvents that do not affect the reaction such as hydrogen, aliphatic hydrocarbons such as pentane and hexane, aprotic polar solvents such as dimethylformamide, N-methylpyrrolidin-2-one, and dimethyl sulfoxide
- an organic acid such as trifluoroacetic acid or an inorganic acid such as hydrochloric acid.
- the reaction time is completed in several minutes to 48 hours.
- reaction from compound (XXIV) to compound (XXV) is carried out by synthesis of isocyanate by Curtius rearrangement and subsequent supplementation with alcohol.
- the compound (XXIV) is activated with oxalyl dichloride or thionyl chloride or carbonyldiimidazole, and then reacted with an azide such as sodium azide or tetra-n-butylammonium azide, the isocyanate produced Can be converted to the protected amine by supplementing with the corresponding alcohol.
- compound (XXIV) can be converted to isocyanate at once using diphenylphosphoric acid azide.
- the reaction in the first activation is usually carried out at 0 to 150 ° C., preferably 0 to 100 ° C., and the reaction time is usually 10 minutes to 48 hours, preferably 1 to 10 hours, followed by The reaction is usually performed for 10 minutes to 24 hours, preferably 1 to 10 hours, and is usually performed at ⁇ 20 to 150 ° C., preferably 0 to 100 ° C.
- the last supplement with alcohol is usually 10 minutes to 48 hours, preferably 1 to 10 hours, and is usually 0 to 150 ° C., preferably room temperature to 100 ° C.
- the hydrolysis reaction of compound (XXV) can be carried out in the same manner as in step 1-2, and the carbon increase reaction for obtaining compound (XXVII) can be carried out in the same manner as in step 1-1.
- the reaction of compound (XXVII) with orthoformates (a) and dimethylformamide dialkylacetals (e) can be carried out in the same manner as in Step 4-1.
- the reaction with compound (c) and the cyclization reaction for obtaining compound (XXIX) can be carried out in the same manner as in step 1-1.
- the deprotection reaction of the amino protecting groups R 15 and R 19 of compound (XXIX) is carried out by a general method.
- any solvent may be used for this reaction as long as it does not affect the reaction.
- aromatic hydrocarbons such as toluene and xylene, diethyl ether, Ethers such as tetrahydrofuran and dioxane, aliphatic hydrocarbons such as pentane and hexane, halogenated hydrocarbons such as methylene chloride, chloroform and carbon tetrachloride, aprotic polar solvents such as dimethylformamide and dimethyl sulfoxide, methanol, Examples thereof include alcohols such as ethanol and propanol.
- the acidic compound used include inorganic acids such as hydrochloric acid and organic acids such as trifluoroacetic acid. This reaction is usually carried out at 0 to 80 ° C., preferably 0 ° C. to room temperature, and the reaction time is usually completed in 5 minutes to 10 hours.
- the bromination reaction of compound (XXX) is performed using a brominating agent such as N-bromosuccinimide and 1,3-dibromo-5,5-dimethyl-2,4-imidazolinedione in a strong acid such as concentrated sulfuric acid. .
- the reaction temperature is desirably ⁇ 10 ° C. to 80 ° C., and the reaction time is desirably 72 to 120 hours.
- the amount of brominating agent used is preferably equimolar to 5-fold molar relative to compound (XXX).
- R 3a represents a lower alkyl group
- R 10 , L 1 and L 2 represent the same as described above.
- the lower alkyl group represented by R 3a is preferably a C 1-4 alkyl group such as a methyl group, an ethyl group, a propyl group or a butyl group, more preferably a methyl group.
- the alkylation and transfer reaction of compound (XXXII) is usually carried out by activating compound (XXXII) with a strong base such as lithium diisopropylamide and then adding an alkylating agent such as iodomethane or iodoethane.
- a compound (XXXIII) in which conversion of a bromine atom to an alkyl group and transfer of the bromine atom to a carboxyl group ortho position proceeded is obtained.
- Any solvent may be used as long as it does not affect the reaction. Examples thereof include ethers such as diethyl ether, tetrahydrofuran and dioxane, and aliphatic hydrocarbons such as pentane and hexane.
- the reaction in the activation is usually performed at ⁇ 78 ° C. to 0 ° C., preferably ⁇ 78 ° C. to ⁇ 50 ° C., and the reaction time is usually 10 minutes to 2 hours, preferably 15 minutes to 1 hour.
- the transfer reaction is usually carried out at 0 ° C. to 100 ° C., preferably 0 ° C. to 50 ° C., and the reaction time is usually 30 minutes to 24 hours, preferably 1 to 10 hours.
- R 20 represents a hydrogen atom or a lower alkyl group
- R 21 represents an amino group protecting group
- R 1a , R 3 , R 4a represent the same as described above.
- the lower alkyl group represented by R 20 is preferably a C 1-4 alkyl group such as a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, or a tert-butyl group, and more preferably A methyl group and an ethyl group;
- the amino group protecting group represented by R 21 is preferably a benzyloxycarbonyl group, a tert-butoxycarbonyl group, an allyloxycarbonyl group, a 2,2,2-trichloroethoxycarbonyl group, more preferably allyloxy It is a carbonyl group.
- Introduction of an amino-protecting group to compound (XXXIV) can be achieved by introducing benzyl chloroformate, di-tert-butyl dicarbonate, allyl chloroformate, 2,2,2-trichloroethyl chloroformate, etc. into an aromatic group such as toluene, xylene, etc.
- Hydrocarbons such as diethyl ether, tetrahydrofuran and dioxane, aliphatic hydrocarbons such as pentane and hexane, halogenated hydrocarbons such as methylene chloride, chloroform and carbon tetrachloride, dimethylformamide, N-methylpyrrolidine
- a solvent that does not affect the reaction such as an aprotic polar solvent such as 2-one or dimethyl sulfoxide
- a deoxidizer such as sodium carbonate, calcium carbonate, sodium bicarbonate, potassium carbonate, sodium hydroxide is used as necessary.
- DBU diazabicyclo [5.4.0] undec-7-ene
- the elimination of the amino group protecting group R 21 of the compound (XXXVI) is carried out by a general deprotection reaction.
- a general deprotection reaction For example, in the presence of additives such as dimedone, trimethylsilyldimethylamine, and 1,3-dimethylbarbituric acid, a catalytic amount of tetrakis (triphenylphosphine) palladium (0), tris (dibenzylideneacetone) dipalladium (0), etc.
- the reaction is carried out using palladium in a suitable solvent. Any solvent may be used for this reaction as long as it does not affect the reaction.
- aromatic hydrocarbons such as toluene and xylene, ethers such as diethyl ether, tetrahydrofuran and dioxane, pentane, and the like.
- Aliphatic hydrocarbons such as hexane, halogenated hydrocarbons such as methylene chloride, chloroform, carbon tetrachloride, aprotic polar solvents such as dimethylformamide, N-methylpyrrolidin-2-one, dimethyl sulfoxide, etc. It is done. This reaction is usually carried out at 0 to 50 ° C., preferably 0 to 35 ° C., and the reaction time is usually completed in several minutes to 10 hours.
- R 5b represents a hydroxyl-protecting group
- R 1a , R 3 , R 20 and R 21 represent the same as those described above.
- compound (XXXVII) was obtained by introducing a hydroxyl protecting group into compound (XXXV), and then compound (1A2) was obtained by removing the amino group protecting group in the same manner as in Step 8-1. obtain.
- the hydroxyl protecting group represented by R 5b is preferably a lower alkylcarbonyl group such as an acetyl group, a propanoyl group, a butanoyl group, a 2-methylpropanoyl group, a pentanoyl group, and more preferably an acetyl group.
- a hydroxyl protecting group to compound (XXXV) can be carried out by symmetric acid anhydrides such as acetic anhydride, propionic anhydride, butyric anhydride, isobutyric anhydride, etc., or acetic acid pivalic acid anhydride, propionic acid pivalic acid anhydride, butyric acid pivalic acid anhydride Products, asymmetric acid anhydrides such as isobutyric acid pivalic acid anhydride, aromatic hydrocarbons such as toluene and xylene, ethers such as diethyl ether, tetrahydrofuran and dioxane, and aliphatic hydrocarbons such as pentane and hexane In a solvent that does not affect the reaction, such as halogenated hydrocarbons such as methylene chloride, chloroform, carbon tetrachloride, aprotic polar solvents such as dimethylformamide, N-methylpyrrolidin-2-one,
- R 22 represents an alkyl group, and R 1a , R 3 , and R 20 represent the same as described above. ]
- an alkyl group is introduced into compound (1A3) to obtain compound (1A4) or compound (1A5).
- Preferred examples of the alkyl group represented by R 22 include a methyl group, an ethyl group, an isopropyl group, (5-methyl-2-oxo-1,3-dioxol-4-yl) methyl, and more preferably ( 5-methyl-2-oxo-1,3-dioxol-4-yl) methyl group.
- an alkyl group into the compound (1A3) is carried out by using an alkyl halide such as iodomethane, iodoethane, 4-halomethyl-5-methyl-2-oxo-1,3-dioxole, or an aromatic hydrocarbon such as toluene or xylene.
- an alkyl halide such as iodomethane, iodoethane, 4-halomethyl-5-methyl-2-oxo-1,3-dioxole, or an aromatic hydrocarbon such as toluene or xylene.
- Ethers such as diethyl ether, tetrahydrofuran and dioxane, aliphatic hydrocarbons such as pentane and hexane, halogenated hydrocarbons such as methylene chloride, chloroform and carbon tetrachloride, dimethylformamide, N-methylpyrrolidin-2-one
- a solvent that does not affect the reaction such as an aprotic polar solvent such as dimethyl sulfoxide
- a deoxidizer such as sodium carbonate, calcium carbonate, sodium hydrogen carbonate, potassium carbonate, sodium hydroxide, triethylamine, Diisopropylethylamine, 1,8- Diazabicyclo [5.4.0] undec-7-ene (DBU), tetramethylguanidine and the like
- additives such as lithium iodide and potassium iodide in the presence at room temperature to 100 ° C., from room temperature to Performed at 100 ° C.
- the reaction time is completed in
- the pyridonecarboxylic acid derivative of the present invention thus obtained is isolated and purified according to a conventional method. Depending on the isolation and purification conditions, it can be obtained in the form of a salt, a free carboxylic acid or a free amine, which are converted to each other as desired to produce the desired form of the compound of the present invention.
- the pyridonecarboxylic acid derivative or salt thereof of the present invention thus obtained has excellent antibacterial activity against bacteria such as methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Clostridium difficile as shown in Test Examples 1 and 2. And has the property of being hardly affected by the drug discharge pump against Pseudomonas aeruginosa. Therefore, the pyridonecarboxylic acid derivative of the present invention or a salt thereof can be used as a clinically useful antibacterial agent.
- the antibacterial agent of the present invention is prepared as an antibacterial agent composition (pharmaceutical preparation) together with a pharmaceutically acceptable carrier for parenteral administration such as injection, rectal and eye drops, or oral administration in solid or liquid form. obtain.
- Examples of the preparation for injection include pharmaceutically acceptable sterile water or non-aqueous solution, suspension or emulsion.
- suitable non-aqueous carriers, diluents, solvents or vehicles include propylene glycol, polyethylene glycol, vegetable oils such as olive oil and injectable organic esters such as ethyl oleate.
- Such compositions can also contain adjuvants such as preservatives, wetting agents, emulsifying agents and dispersing agents. These compositions can be reduced, for example, by filtration through a bacteria retaining filter or by incorporating the sterilizing agent in the form of a sterile solid composition that can be dissolved in a sterilizing agent or some other sterilized injectable medium immediately before use. Can be fungus.
- a solubilizing agent, preservative, isotonic agent, thickener and the like can be preferably added in addition to the compound of the present invention.
- Solid preparations for oral administration include capsules, tablets, pills, powders and granules.
- the pyridonecarboxylic acid derivative of the present invention or a salt thereof is generally mixed with at least one inert diluent such as sucrose, lactose or starch.
- This formulation may also use additional materials other than inert diluents, such as lubricants (eg, magnesium stearate) in normal formulations.
- lubricants eg, magnesium stearate
- a buffering agent may be further used. Tablets and pills may be enteric coated.
- Liquid formulations for oral administration include pharmaceutically acceptable emulsions, solutions, suspensions, syrups and elixirs containing inert diluents commonly used by those skilled in the art, such as water.
- the composition may also contain adjuvants such as wetting agents, emulsifying agents, suspending agents, and sweetening, flavoring and flavoring agents.
- Formulations for rectal administration may preferably contain excipients such as cocoa butter or suppository waxes in addition to the compound of the present invention.
- the dosage of the antibacterial agent of the present invention depends on the properties of the compound to be administered, the route of administration, the desired treatment period and other factors. About 0.1 to 1000 mg / kg per day, particularly about 0.5 to 100 mg / kg is preferred. If desired, this daily dose can be divided into 2 to 4 doses.
- the obtained compound (20.0 g) and lithium chloride (3.6 g) were dissolved in N-methylpyrrolidin-2-one (84 g), and 1,8-diazabicyclo [5.4.0] undec-7-ene (6.8 g) was added to the mixture at 80 ° C for 1 hour. Stir for hours. After allowing to cool, the reaction solution was poured into 800 mL of water, and the precipitated crystals were collected by filtration and dried. The crystals were dissolved in 800 mL of chloroform and washed with water. The organic layer was dried over anhydrous magnesium sulfate and evaporated under reduced pressure. The obtained residue was dispersed in diisopropyl ether, collected by filtration and dried to obtain 17.5 g of the title compound.
- reaction mixture was neutralized by adding 0.33 mL of 6 mol / L hydrochloric acid, and the precipitated crystals were collected by filtration, washed with water and then acetonitrile, and dried to obtain 110 mg of the title compound.
- the obtained oil was dissolved in 30 mL of chloroform, 100 mg of triethylamine 100 mg of di-t-butyl dicarbonate was added, and the mixture was stirred at room temperature for 2 hours.
- the reaction solution was washed with 10% aqueous citric acid solution, brine, then saturated aqueous sodium hydrogen carbonate solution, and dried over anhydrous magnesium sulfate.
- the residue obtained by distilling off the organic layer under reduced pressure was separated with a silica gel column (0-1% methanol / chloroform).
- the obtained compound was dissolved in 2 mL of methanol, 3 mL of 4 mol / L hydrogen chloride / 1,4-dioxane was added, and the mixture was stirred at room temperature for 1 hour.
- the extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. To the obtained crystalline residue was added 5.0 mL of acetonitrile. The precipitate was collected by filtration to obtain 0.11 g of the title compound.
- Ethyl 1- (2-acetoxymethyl-5-amino-4-fluorophenyl) -8-bromo-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 0.10 mg to methanol 2.0 mL Then, 55 mg of potassium carbonate was added and stirred overnight at room temperature. The precipitate was collected by filtration and washed with 2.0 ml of water tank to give 56 mg of the title compound.
- reaction solution was washed with water and then dried over anhydrous magnesium sulfate.
- residue obtained by distilling off the solvent under reduced pressure was dispersed in n-hexane, collected by filtration and dried to obtain 29.3 g of the title compound.
- the reaction mixture was washed with water and then with a saturated aqueous sodium hydrogen carbonate solution, dried over anhydrous magnesium sulfate, and evaporated under reduced pressure.
- the obtained residue was dispersed in diisopropyl ether, collected by filtration and dried to obtain 10.6 g of the title compound.
- a 24: 1 mg mixture of a 1: 1 mixture of ethyl (2-hydroxyethyl) amino-4-oxo-1,4-dihydroquinoline-3-carboxylate and its deacetylated form was obtained.
- the reaction mixture was diluted with 10 mL of dichloromethane, washed with 10 mL of saturated aqueous sodium bicarbonate and 10 mL of saturated brine, and dried over anhydrous sodium sulfate.
- Ethanol 1- (2-acetoxymethyl-5-amino-4-fluorophenyl) -7-amino-8-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 40 mg ethanol 0.50 mL, 10 mol / L sodium hydroxide aqueous solution 80 ⁇ L, and water 0.50 mL were added and stirred at 50 ° C. for 4 hours. 1 mol / L hydrochloric acid was added to make the solution acidic (pH 6 to 7). The precipitate was collected by filtration to obtain 27 mg of the title compound.
- 0.21 mL mL of triethylamine and 38 mg of 3-methyl-3-methylaminoazetidine dihydrochloride were added at room temperature, and the mixture was stirred at room temperature for 4 days.
- the precipitate was collected by filtration with acetonitrile to obtain 62 mg of the title compound.
- the resulting solution was dried over anhydrous sodium sulfate.
- the solvent was distilled off under reduced pressure.
- the obtained residue was dissolved in 2.0 mL of chloroform, 4 mol / L hydrogen dioxane solution was added at room temperature, and the mixture was stirred at room temperature for 3 hours.
- the reaction solution was distilled off under reduced pressure, and the resulting residue was dissolved in 1.0 mL of ethanol, and 3 mol / L of sodium hydroxide aqueous solution of 0.40 mL was added at room temperature and stirred overnight at room temperature.
- Ethanol was distilled off under reduced pressure and then neutralized with hydrochloric acid. The precipitate was taken up with water to obtain 40 mg of the title compound.
- the solvent was distilled off under reduced pressure, and the residue was dissolved in 200 mL of chloroform.
- the organic layer was washed with water and then with a saturated aqueous sodium hydrogen carbonate solution, dried over anhydrous magnesium sulfate, and evaporated under reduced pressure.
- the obtained residue was dispersed in ethyl acetate, collected by filtration and dried to obtain 1.40 g of the title compound.
- the precipitated crystals were collected by filtration and dried to obtain 120 mg of the crude title compound. This was added and dissolved in 16 mL of 0.5 mol / L hydrochloric acid, and the insoluble material was removed by filtration. The filtrate was neutralized with a saturated aqueous sodium hydrogen carbonate solution, and the precipitated crystals were collected by filtration. The crystals were washed with water and then with ethanol and dried to obtain 55 mg of the title compound.
- the precipitated crystals were collected by filtration, washed with water and then with ethanol, and then dried to obtain 110 mg of the crude title compound. This was suspended in 12 mL of 1.0 mol / L hydrochloric acid, stirred at room temperature for 30 minutes, neutralized by adding a 4 mol / L aqueous sodium hydroxide solution, and the crystals were collected by filtration. The crystals were washed with water and then with ethanol and dried to give 68 mg of the title compound.
- Iron powder (1.0 g) was added to ethanol (3 mL) and water (2 mL), concentrated hydrochloric acid () 0.5 mL was added thereto, and the mixture was stirred at 80 ° C for 20 minutes.
- reaction solution was filtered through Celite, and Celite was washed 4 times with 20 mL of tetrahydrofuran, 4 times with 20 mL of ethanol, and 3 times with 20 mL of dichloromethane.
- the filtrates were combined and concentrated. 10 mL of water was added and the solid was collected by filtration. Washing with 3 mL of ethanol gave 22 mg of the title compound.
- the solvent was distilled off under reduced pressure, and the residue was dissolved in 300 mL of chloroform.
- the organic layer was washed with water and then with a saturated aqueous sodium hydrogen carbonate solution, dried over anhydrous magnesium sulfate, and evaporated under reduced pressure.
- the obtained residue was separated on a silica gel column (0-2% methanol / chloroform) to obtain 660 mg of the title compound.
- reaction mixture was neutralized by adding 0.33 mL of 6 mol / L hydrochloric acid, and the precipitated crystals were collected by filtration, washed with water and then acetonitrile, and dried to obtain 120 mg of the title compound.
- the obtained powder was suspended in 2 ml of water, 0.083 ml of 6 mol / L sodium hydroxide aqueous solution was added and stirred, and the resulting precipitate was collected by filtration to obtain 0.152 g of the title compound.
- Methyl 2-amino-4- (2,4-dimethoxybenzyl) amino-5-fluorobenzoate (334 mg) and lithium borohydride (50 mg) were added to a mixture of tetrahydrofuran (5 mL) and toluene (20 mL), and the mixture was heated to reflux for 5 hours. 25 mL of ethyl acetate was added to the reaction solution, and the mixture was washed 3 times with a saturated aqueous sodium hydrogen carbonate solution. The organic layer was dried over anhydrous magnesium sulfate and filtered to obtain a crude [2-amino-4- (2,4-dimethoxybenzyl) amino-5-fluorophenyl] methanol solution.
- Ethyl 2-amino-4- (2,4-dimethoxybenzylamino) -5-fluorobenzoate (3.44 g) was added to 100 mL of toluene and 25 mL of tetrahydrofuran. 897 mg of lithium borohydride was added and stirred at 100 ° C. for 90 minutes. Under ice cooling, 100 mL of water was added and stirred for 20 minutes. The aqueous solution was extracted with 100 mL of ethyl acetate. The organic layer was dried over anhydrous sodium sulfate.
- the insoluble material was filtered off using Celite, and Celite was washed 3 times with 30 ml of dichloromethane.
- the filtrates were combined and concentrated under reduced pressure, 70 mL of water was added to the residue, and the mixture was extracted with 200 mL of dichloromethane, the organic layer was dried over anhydrous sodium sulfate, hexane was added to the residue, and the mixture was collected by filtration. 1.12 g of the title compound was obtained.
- Methyl 2-amino-4- (2,4-dimethoxybenzyl) amino-5-fluorobenzoate (0.100 g) was suspended in 4 mL of toluene and 1 mL of tetrahydrofuran, added with 26 mg of lithium borohydride, and stirred at 80 ° C. for 2 hours. .
- the reaction mixture was cooled to room temperature, water was added, the mixture was extracted with ethyl acetate, and dried over anhydrous sodium sulfate. After anhydrous sodium sulfate was removed by filtration, the above dichloromethane solution was added to the filtrate, and the mixture was stirred at room temperature for 2 days.
- This solid was added to a mixed solution of 100 mL of chloroform and 100 mL of methanol, and stirred for 20 minutes while heating under reflux. The insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was added with 10 mL of water and collected by filtration to obtain 400 mg of the title compound.
- Methyl 2-amino-4- (2,4-dimethoxybenzylamino) -5-fluorobenzoate (2.01 g) was suspended in 50 ml of toluene and 15 ml of tetrahydrofuran, 0.26 g of lithium borohydride was added, and the mixture was refluxed for 1 hour.
- the reaction mixture was added to ice water, extracted with ethyl acetate, and dried over anhydrous magnesium sulfate. After anhydrous magnesium sulfate was removed by filtration, the above methylene chloride solution was added to the filtrate, and the mixture was stirred at room temperature for 20 hours.
- reaction solution 1.5 mL of iodomethane, and the mixture was stirred at room temperature for 3 hours.
- the reaction solution was added with 100 ⁇ mL of 1 mol / L hydrochloric acid to adjust the pH to about 5, and then extracted three times with 100 mL of ethyl acetate.
- the extract was washed with 100 mL of 1 mol / L hydrochloric acid and 100 mL of saturated brine, and then dried over anhydrous sodium sulfate. After anhydrous sodium sulfate was removed by filtration, the solvent was distilled off under reduced pressure. The obtained crystalline residue was filtered with toluene to obtain 2.1 g of the title compound as a light brown solid.
- ethyl 2- (2-bromo-5-methyl-3,4,6-trifluorobenzoyl) acetate was added with 2.3 ml of acetic anhydride and 2 ml of triethyl orthoformate and stirred at 120 ° C. for 5.5 hours.
- the reaction mixture was concentrated and azeotroped three times with toluene to give ethyl 2- (2-bromo-5-methyl-3,4,6-trifluorobenzoyl) -3-ethoxyacrylate as a brown oil. .
- the obtained amorphous was dissolved in 40 mL of N-methyl-2-pyrrolidone, 0.68 g of lithium chloride, and 1.32 mL of 1,8-diazabicyclo [5.4.0] undec-7-ene were added, and the mixture was stirred at 60 ° C for 2 hours. .
- the reaction solution was added to water, and the precipitate was collected by filtration.
- the precipitate was collected by filtration, washed with methylene chloride, and suspended in 30 mL of ethyl acetate. This was washed 5 times with 20 mL of saturated aqueous sodium hydrogen carbonate solution and 30 mL of saturated brine, and then dried over anhydrous sodium sulfate. After anhydrous sodium sulfate was removed by filtration, the solvent was distilled off under reduced pressure to obtain 22 mg of the title compound as a white solid.
- the precipitate was collected by filtration, washed with methylene chloride, and suspended in 30 mL of ethyl acetate. This was washed 5 times with 20 mL of saturated aqueous sodium hydrogen carbonate solution and 30 mL of saturated brine, and then dried over anhydrous sodium sulfate. After anhydrous sodium sulfate was removed by filtration, the solvent was distilled off under reduced pressure to obtain 13 mg of the title compound as a white solid.
- the precipitate was collected by filtration, washed with methylene chloride, and suspended in 30 mL of ethyl acetate. This was washed 5 times with 20 mL of saturated aqueous sodium hydrogen carbonate solution and 30 mL of saturated brine, and then dried over anhydrous sodium sulfate. After anhydrous sodium sulfate was removed by filtration, the solvent was distilled off under reduced pressure to obtain 7 mg of the title compound as a pale yellow solid.
- Example 166 1- [5-Amino-4-fluoro-2- (hydroxymethyl) phenyl] -5,8-dimethyl-6-fluoro-7- ⁇ 3- [N-methyl-N- (5-methyl-2-oxo -1,3-dioxol-4-yl) methylamino] azetidin-1-yl ⁇ -4-oxo-1,4-dihydroquinoline-3-carboxylic acid 1- [5-amino-4-fluoro-2- ( Hydroxymethyl) phenyl] -5,8-dimethyl-6-fluoro-7- (3-methylaminoazetidin-1-yl) -4-oxo-1,4-dihydroquinoline-3-carboxylic acid 46 mg to N , N-dimethylformamide (1.2 mL) and potassium carbonate (14 mg) were added, and the mixture was stirred at 45 ° C for 15 min.
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Abstract
Description
さらに、キノロン系抗菌剤の投与により、腸内細菌叢が攪乱された結果、キノロン耐性クロストリジウム・ディフィシルが原因となる抗菌剤関連下痢症が問題となっている(非特許文献5~6)。
しかしながら、当該誘導体においてもこれに耐性を示すメチシリン耐性黄色ブドウ球菌や緑膿菌が確認され、十分な効果が得られないという問題があった。
1)下記式(1):
で表される環状アミノ基を示し、R3は水素原子、ハロゲン原子、低級アルキル基又は低級アルコキシ基を示し、R4は水素原子又はカルボキシル基保護基を示し、R5は水素原子又は水酸基保護基を示す。〕
で表されるピリドンカルボン酸誘導体又はその塩。
3)R3で示される低級アルコキシ基がC1-4アルコキシ基である1)又は2)のピリドンカルボン酸誘導体又はその塩。
4)R3で示されるハロゲン原子がフッ素原子、塩素原子又は臭素原子である1)~3)のいずれかのピリドンカルボン酸誘導体又はその塩。
5)R1が水素原子、メチル基、臭素原子又はアミノ基であり、R2が式(2)で表される環状アミノ基である、1)~4)のいずれかのピリドンカルボン酸誘導体又はその塩。
6)式(2)においてYがC-R9aR9bであり、n及びpが1である5)のピリドンカルボン酸誘導体又はその塩。
7)C-R9aR9bにおいてR9aが水素原子であり、R9bがC1-4アルキルアミノ基である6)のピリドンカルボン酸誘導体又はその塩。
8)R4が水素原子又は生体内で容易に脱離する保護基であり、R5が水素原子又は生体内で容易に脱離する保護基である1)~7)のいずれかのピリドンカルボン酸誘導体又はその塩。
9)1)~8)のいずれかのピリドンカルボン酸誘導体又はその塩を有効成分とする抗菌剤。
10)1)~8)のいずれかのピリドンカルボン酸誘導体又はその塩及び製薬上許容し得る担体を含有する抗菌剤組成物。
11)抗菌剤を製造するための1)~8)のいずれかのピリドンカルボン酸誘導体又はその塩の使用。
12)感染症を予防又は治療するために使用される1)~8)のいずれかのピリドンカルボン酸誘導体又はその塩。
13)1)~8)のいずれかのピリドンカルボン酸誘導体又はその塩を投与することを特徴とする感染症の処置方法。
また、「置換基を有していてもよい」とは、対象となる基の水素原子が他の基に置換されていてもよいことを意味し、当該置換基の数は、1若しくはそれ以上であり得、置換基を2以上有する場合、当該置換基は同一又は異なっていてもよい。
以下に、式(1)において使用した記号について説明する。
当該置換基としては、例えばアゼチジン-3-イル基、1-メチルアゼチジン-3-イル基、ピロリジン-3-イル基、1-メチルピロリジン-3-イル基が好適に挙げられる。
なお、R4は、水素原子であるのが好ましい。
なお、R5は、水素原子であるのが好ましい。
(工程1-1)
R11、R12、R13で示される「低級アルキル基」としては、好ましくはC1-3アルキル基であり、更に好ましくはエチル基である。
R14で示される「低級アルカノイル基」としては、好ましくはC1-7アルカノイル基が挙げられ、好適には、アセチル基、プロピオニル基、ブチリル基、バレリル基等が挙げられる。
L1及びL2で示されるハロゲン原子としては、好ましくは塩素原子、フッ素原子が挙げられる。
本反応は、通常0~150℃、好ましくは室温~100℃で行われ、反応時間は通常、10分~48時間で終了する。さらに、反応条件により、R10の加水分解を伴いカルボン酸が得られることがある。その際は再度低級アルキルエステル化を行う。エステル化は、芳香族カルボン酸に用いられる一般的な方法が用いられる。エステル化法としては、塩化チオニルもしくは二塩化オキサリル等を用いて得られる酸塩化物を経由し、相当する低級アルコールを用いて行われる。酸塩化物を得るための反応温度は、通常-10℃~150℃、好ましくは0℃~100℃で行われ反応時間は通常10分~48時間、好ましくは1~10時間が望ましく、続く低級アルコールとの反応は通常0℃~150℃、好ましくは0℃~100℃で行われ反応時間は通常10分~48時間、好ましくは1~10時間である。
また、別法として化合物(VI)の保護基を脱離して化合物(VII)とし、同様の置換反応を行って化合物(1C)を得ることもできる。L2がアミノ基である化合物(1D)は、化合物(1A)を加水分解等の脱保護反応により保護基の脱離を行えば得ることができる。
R2a-H(化合物(c))の使用量は、化合物(VI)に対し、等モル~5倍モルとするのが良い。また、この反応は弱いルイス酸として塩化リチウム等のリチウム塩存在下で反応を行う場合もある。
R4aで示されるカルボキシル基保護基、R5aで示される水酸基保護基はそれぞれR4及びR5で示したものと同様のものが挙げられる。
(工程2-1)
化合物(X)のアミノ保護基R15の脱離は一般的な脱保護反応により行われる。例えばアニソール等のカチオン補足剤の存在下、酸性化合物を用いて適当な溶媒中で行われる。本反応に使用される溶媒としては、該反応に影響しないものであればいずれでも良く、例えば、トルエン、キシレン等のような芳香族炭化水素類、ジエチルエーテルやテトラヒドロフラン、ジオキサン等のエーテル類、ペンタン、ヘキサン等の脂肪族炭化水素類、塩化メチレン、クロロホルム、四塩化炭素等のハロゲン化炭化水素類、ジメチルホルムアミド、ジメチルスルホキシド等の非プロトン性極性溶媒、メタノール、エタノール、プロパノール等のアルコール等が挙げられる。また、使用される酸性化合物としては、塩酸等の無機酸、トリフルオロ酢酸等の有機酸類が挙げられる。本反応は、通常0~80℃、好ましくは0℃~室温で行われ、反応時間は通常、5分~10時間で終了する。
化合物(XVII)におけるR15を脱離するための脱保護反応は、工程2-1と同様の方法で行うことができる。
アセタール類との反応に使用される溶媒としては、該反応に影響しないものならいずれを用いてもよく、例えば、トルエン、キシレン等のような芳香族炭化水素類、ジエチルエーテルやテトラヒドロフラン、ジオキサン等のエーテル類、ペンタン、ヘキサン等の脂肪族炭化水素類、塩化メチレン、クロロホルム、四塩化炭素等のハロゲン化炭化水素類、ジメチルホルムアミド、ジメチルスルホキシド等の非プロトン性極性溶媒、メタノール、エタノール、プロパノール等のアルコール等が挙げられる。本反応は、通常0~150℃、好ましくは室温~100℃で行われ、反応時間は通常、10分~48時間、好ましくは1~10時間である。
R18で示される低級アルキル基としては、C1-4アルキル基が好ましく、より好ましくはt-ブチル基である。
R19で示されるアミノ保護基としては、好ましくはベンジルオキシカルボニル基、t-ブトキシカルボニル基、アリルオキシカルボニル基、2,2,2-トリクロロエトキシカルボニル基等が挙げられ、より好ましくはt-ブトキシカルボニル基である。
化合物(XXVII)とオルトギ酸エステル類(a)、ジメチルホルムアミドジアルキルアセタール類(e)との反応は工程4-1と同様の方法で行うことができる。
また、化合物(c)との反応、化合物(XXIX)を得るための環化反応は、工程1-1と同様の方法で行うことができる。
経口投与のための固形製剤にはカプセル剤、錠剤、丸剤、散剤及び顆粒剤等が挙げられる。この固形製剤の調製にあたっては一般に本発明のピリドンカルボン酸誘導体又はその塩を少なくとも1種の不活性希釈剤、例えばスクロース、乳糖又はでんぷんと混和する。この製剤はまた通常の製剤化において不活性希釈剤以外の追加の物質例えば滑沢剤(例えばステアリン酸マグネシウム等)を用いてもよい。カプセル剤、錠剤及び丸剤の場合には、更に、緩衝剤を用いてもよい。錠剤及び丸剤には腸溶性被膜を施してもよい。
得られた化合物をメタノール2 mLに溶解し、4mol/L塩化水素/1,4-ジオキサン3 mLを加えて室温で1時間撹拌した。溶媒を減圧留去して粗製の塩酸塩を得た。この塩酸塩をエタノール2 mLに懸濁し、1mol/L水酸化ナトリウム水溶液2 mLを加えて50℃で15分間撹拌した。放冷後、6M塩酸0.33 mLを加えて中和して減圧留去した。得られた残渣を20%メタノール/クロロホルムに溶解して、無水硫酸マグネシウムで乾燥後、減圧留去した。残渣をエタノールより結晶化して標記化合物を5 mg得た。
得られた化合物にアセトニトリル 1.0 mL、1-(2-アセトキシメチル-5-アミノ-4-フルオロフェニル)-8-ブロモ-6,7-ジフルオロ-4-オキソ-1,4-ジヒドロキノリン-3-カルボン酸エチル 0.15 g、1,1,3,3-テトラメチルグアニジン 0.13 mL を加え室温で一晩撹拌した。反応液を濃縮し、アセトニトリル0.50 mLに懸濁させた。析出物を濾取し、標記化合物 0.13 gを得た。
得られた化合物230 mgをエタノール2 mLに懸濁し、1mol/L水酸化ナトリウム水溶液2 mLを加えて80℃で30分間撹拌した。放冷後、6mol/L塩酸0.33 mLを加えて中和した。反応液を減圧濃縮して析出した粉末を濾取、水、次いでアセトニトリルで洗浄し、乾燥して標記化合物を160 mg得た。
得られた化合物をエタノール2 mLに懸濁し、1mol/L水酸化ナトリウム水溶液2 mLを加えて60℃で30分間撹拌した。放冷後、6mol/L塩酸0.33 mLを加えて中和して析出晶を濾取し、水、次いでアセトニトリルで洗浄後、乾燥して標記化合物を160 mg得た。
上記で得られた3-(テトラヒドロピラン-4-イル)アミノアゼチジン塩酸塩にアセトニトリル 1.0 mL、1-(2-アセトキシメチル-5-アミノ-4-フルオロフェニル)-8-クロロ-6,7-ジフルオロ-4-オキソ-1,4-ジヒドロキノリン-3-カルボン酸エチル 0.14 g、1,1,3,3-テトラメチルグアニジン 0.13 mL を加え室温で一晩撹拌した。反応液を濃縮し、アセトニトリル0.50 mLに懸濁させた。析出物を濾取し、標記化合物 0.12 gを得た。
残渣ににジクロロメタン1.0 mL、4mol/L 塩酸/1,4-ジオキサン 0.50 mLを氷冷下で加え、室温で1時間攪拌した。反応液をジクロロメタン 10 mLで希釈した後、飽和重曹水 10 mL、飽和食塩水 10 mLで洗浄後、無水硫酸ナトリウムで乾燥した。溶媒を減圧下留去し、残渣をシリカゲルカラムクロマトグラフィー(ジクロロメタン:メタノール= 0 - 10% グラジエント)に付し、標記化合物 40 mg を得た。
得られた化合物に無水酢酸3 mL およびオルトギ酸エチル3 mLを加え、130℃で6時間撹拌し、溶媒を減圧下留去した。残渣をトルエンで二回共沸し、得られた残渣をジクロロメタンに溶かし、1mol/L 溶液を調整し次の反応に使用した。
2-アミノ-5-フルオロフェニルメタノール 4.19 g にN,N-ジメチルホルムアミド 29.7 mLおよび先に調整したエトキシアクリレートのジクロロメタン溶液29.7 mLを加え、室温で1時間攪拌した。減圧下、溶媒を留去し、残渣に酢酸エチルを加え、水を用いて洗浄した。有機層を無水硫酸ナトリウムを用いて乾燥し、減圧下、溶媒を留去した。得られた残渣をヘキサンを用いて分散し、濾取した。減圧下、乾燥し、標記化合物10.4 gを得た。
上記溶液(5 mmol)に1mol/Lの3-エトキシ-2-(2,4,5-トリフルオロ-3-メトキシベンゾイル)アクリル酸エチルのジクロロメタン溶液(5 mL)を滴下して室温で一晩撹拌し、溶媒を減圧留去した。得られた3-[5-(2,4-ジメトキシベンジル)アミノ-4-フルオロ-2-(ヒドロキシメチル)フェニルアミノ]-2-(2,4,5-トリフルオロ-3-メトキシベンゾイル)アクリル酸エチルをN-メチルピロリジン-2-オン9 mLに溶解し、塩化リチウム400 mg、1,8-ジアザビシクロ[5.4.0]ウンデク-7-エン680 mgを加えて室温で一晩撹拌した。反応液に水50 mLを加え、析出した結晶を濾取、乾燥した。シリカゲルカラム(0~8%メタノール/クロロホルム)で精製して標記化合物を1.40 g得た。
マロン酸モノエチルカリウム 6.11 g に、アセトニトリル 70 mL、塩化マグネシウム 4.01 g、トリエチルアミン 4.25 g を氷冷下で加え、室温で24時間撹拌し、懸濁液とした。3-クロロ-6-ニトロ-2,4,5-トリフルオロ安息香酸 7.67 g にジクロロメタン 25 mL、DMF 300 μL、塩化オキサリル 7.62 g を加え、室温で18時間撹拌した。溶媒を減圧下留去し、テトラヒドロフラン 40 mL に懸濁し、先の懸濁液に室温で加え、そのまま終夜撹拌した。1mol/L塩酸 180 mL を加えたのち、溶液を酢酸エチルで抽出し、無水硫酸ナトリウムで乾燥した。溶媒を減圧下留去し、残渣をシリカゲルカラムクロマトグラフィー(n-ヘキサン:ジクロロメタン= 50 - 80% グラジエント)に付し、標記化合物 7.12 g を得た。
2-アミノ-4-(2,4-ジメトキシベンジルアミノ)-5-フルオロ安息香酸エチル 3.44 gをトルエン 100 mLとテトラヒドロフラン 25 mLに加えた。水素化ホウ素リチウム 897 mgを加えて100℃で90分撹拌した。氷冷下に水 100 mLを加えて20分撹拌した。水溶液を酢酸エチル 100 mLで抽出した。有機層は無水硫酸ナトリウムで乾燥させた。この有機層に2-(3-クロロ-6-ニトロ-2,4,5-トリフルオロベンゾイル)-3-エトキシアクリル酸エチルを加えて室温で3時間撹拌した。反応液を減圧下に濃縮した。残渣をシリカゲルカラムクロマトグラフィー(ジクロロメタン:酢酸エチル= 10 - 30% グラジエント)に付し、標記化合物 1.19 g を得た。
残渣をエタノール 2 mLに溶解し、1mol/L 水酸化ナトリウム 水溶液 0.157 mL を加え60℃で2 時間撹拌した後、1mol/L 水酸化ナトリウム 水溶液 を0.03mL 追加し、60℃で20分間撹拌した。不溶物濾去後、1mol/L 塩酸 でpH5へ調整し、不溶物を濾去した。ろ液のエタノールを減圧下留去し、DMSO をごく少量加え、不溶物を溶かし、逆相フラッシュカラムクロマトグラフィー(1% 酢酸水: 1% 酢酸/アセトニトリル= 10 - 80% グラジエント)に付し、目的物が含まれるフラクションを凍結乾燥し、標記化合物を15 mg酢酸塩として得た。
得られた残渣55 mgにエタノール 0.50 mL、1mol/L 水酸化ナトリウム 水溶液 0.23 mLを加え50 ℃で1.5時間撹拌した。析出物を濾過後、濾液に1mol/L塩酸を加え溶液を酸性(pH 5 ~ 6)にした後、エタノールを減圧下留去した。残渣をシリカゲルカラムクロマトグラフィー(1%酢酸水溶液:1%酢酸アセトニトリル溶液 = 10 - 80% グラジエント)に付し、フラクションを回収後凍結乾燥し、標記化合物7.3 mgを得た。
1H-NMR (CD3OD): δ1.24-1.35 (1H, m), 1.38-1.46 (1H, m), 2.66-2.70 (1H, m), 3.24-3.28 (2H, m), 4.36 (1H, brm), 5.99 (1H, brm), 6.28 (1H, d, J= 11.8 Hz), 7.55 (1H, d, J = 11.7 Hz), 7.85 (1H, brs).
2-アミノ-4-(2,4-ジメトキシベンジルアミノ)-5-フルオロ安息香酸メチル 1.77 gをトルエン 50 mLとテトラヒドロフラン 15 mLに加えた。水素化ホウ素リチウム 462 mgを加えて100℃で1.5時間撹拌した。氷冷下に水 75 mLを加えて20分撹拌した。水溶液を酢酸エチル 100 mLで抽出した。有機層は無水硫酸ナトリウムで乾燥させた。
この有機層に先の油状物を加えて室温で24時間撹拌した。反応液を減圧下に濃縮した。残渣をシリカゲルカラムクロマトグラフィー(ジクロロメタン:酢酸エチル= 0 - 40% グラジエント)に付し、標記化合物 2.56 g を得た。
1-[5-アミノ-4-フルオロ-2-(ヒドロキシメチル)フェニル]-5,8-ジメチル-6-フルオロ-7-(3-メチルアミノアゼチジン-1-イル)-4-オキソ-1,4-ジヒドロキノリン-3-カルボン酸46 mgにN,N-ジメチルホルムアミド1.2 mL、炭酸カリウム14 mgを加えて45℃で15分間撹拌した。ここにヨウ化カリウム 3.4 mg、4-クロロメチル-5-メチル-1,3-ジオキソール-2-オン11 μLを加え、45℃で3時間攪拌した。冷却後、反応液を酢酸エチル10 mLで希釈し、5%炭酸水素ナトリウム水溶液10 mLで3回洗浄後、無水硫酸ナトリウムで乾燥した。無水硫酸ナトリウムを濾去後、溶媒を減圧留去し、淡褐色固体の標記化合物31 mgを得た。
本発明の化合物について、抗菌作用、薬剤排出ポンプ阻害剤併用抗菌作用の結果を試験例1、2 に示す。比較化合物として、国際公開WO96/23775号公報(特許文献6)に記載の下記化合物を用いた。
比較化合物1:7-(3-アミノアゼチジン-1-イル)-1-(5-アミノ-2,4-ジフルオロフェニル)-8-クロロ-6-フルオロ-4-オキソ-1,4-ジヒドロキノリン-3-カルボン酸、特許文献6 実施例152の化合物
比較化合物2:1-(5-アミノ-2,4-ジフルオロフェニル)-8-クロロ-6-フルオロ-7-(3-メチルアミノアゼチジン-1-イル)-4-オキソ-1,4-ジヒドロキノリン-3-カルボン酸、特許文献6 実施例157の化合物
表1に示す化合物について、日本化学療法学会標準法(日本化学療法学会雑誌,56(1),49 ,2008)に準じ、最小発育阻止濃度(MIC:μg/mL)を測定した。また、従来抗菌剤であるシプロフロキサシン及びレボフロキサシンについて同様に最小発育阻止濃度(MIC:μg/mL)を測定した。P. aeruginosaは亀田総合病院から分与された臨床分離株である。C. difficileはInternational Health Management Associates, Inc.(IHMA)より購入した臨床分離株である。結果を表1に示す。
表2に示す化合物について、薬剤排出ポンプ阻害剤併用抗菌作用を測定した。方法として、日本化学療法学会標準法(Chemotherapy,38(1),102,1990)に準じ、微量液体希釈法により行った。薬剤排出ポンプ阻害剤としてH-Phe-Arg-βNA・2HCl(PAβN)(50μg/mL)を添加した条件において、最小発育阻止濃度(MIC:μg/mL)を測定した。また、評価の陽性対照化合物及び陰性対照化合物として従来抗菌剤であるレボフロキサシン及びセフェピムについてもそれぞれ同様に最小発育阻止濃度(MIC:μg/mL)を測定した。P. aeruginosaは亀田総合病院から分与された臨床分離株である。結果を表2に示す。
Claims (13)
- 下記式(1):
で表される環状アミノ基を示し、R3は水素原子、ハロゲン原子、低級アルキル基又は低級アルコキシ基を示し、R4は水素原子又はカルボキシル基保護基を示し、R5は水素原子又は水酸基保護基を示す。〕
で表されるピリドンカルボン酸誘導体又はその塩。 - R1、R3、R6又はR7で示される低級アルキル基がC1-4アルキル基である請求項1記載のピリドンカルボン酸誘導体又はその塩。
- R3で示される低級アルコキシ基がC1-4アルコキシ基である請求項1又は2記載のピリドンカルボン酸誘導体又はその塩。
- R3で示されるハロゲン原子がフッ素原子、塩素原子又は臭素原子である請求項1~3のいずれか1項記載のピリドンカルボン酸誘導体又はその塩。
- R1が水素原子、メチル基、臭素原子又はアミノ基であり、R2が式(2)で表される環状アミノ基である、請求項1~4のいずれか1項記載のピリドンカルボン酸誘導体又はその塩。
- 式(2)においてYがC-R9aR9bであり、n及びpが1である請求項5記載のピリドンカルボン酸誘導体又はその塩。
- C-R9aR9bにおいてR9aが水素原子であり、R9bがC1-4アルキルアミノ基である請求項6記載のピリドンカルボン酸誘導体又はその塩。
- R4が水素原子又は生体内で容易に脱離する保護基であり、R5が水素原子又は生体内で容易に脱離する保護基である請求項1~7のいずれか1項記載のピリドンカルボン酸誘導体又はその塩。
- 請求項1~8のいずれか1項記載のピリドンカルボン酸誘導体又はその塩を有効成分とする抗菌剤。
- 請求項1~8のいずれか1項記載のピリドンカルボン酸誘導体又はその塩及び製薬上許容し得る担体を含有する抗菌剤組成物。
- 抗菌剤を製造するための請求項1~8のいずれか1項記載のピリドンカルボン酸誘導体又はその塩の使用。
- 感染症を予防又は治療するために使用される請求項1~8のいずれか1項記載のピリドンカルボン酸誘導体又はその塩。
- 請求項1~8のいずれか1項記載のピリドンカルボン酸誘導体又はその塩を投与することを特徴とする感染症の処置方法。
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2017285689A AU2017285689B2 (en) | 2016-06-15 | 2017-06-14 | Novel pyridonecarboxylic acid derivative or salt thereof |
MX2018015462A MX2018015462A (es) | 2016-06-15 | 2017-06-14 | Derivado novedoso del acido piridonacarboxilico o su sal. |
BR112018076175-3A BR112018076175A2 (pt) | 2016-06-15 | 2017-06-14 | novo derivado de ácido piridonacarboxílico ou sal deste |
EP17813336.9A EP3473616A4 (en) | 2016-06-15 | 2017-06-14 | NEW PYRIDONE CARBONIC DERIVATIVE OR SALT THEREOF |
KR1020187035735A KR20190016962A (ko) | 2016-06-15 | 2017-06-14 | 신규 피리돈카르복실산 유도체 또는 그 염 |
JP2017545766A JP6322772B1 (ja) | 2016-06-15 | 2017-06-14 | 新規ピリドンカルボン酸誘導体又はその塩 |
US16/308,292 US10532984B2 (en) | 2016-06-15 | 2017-06-14 | Pyridonecarboxylic acid derivative or salt thereof |
CN201780037381.2A CN109311818A (zh) | 2016-06-15 | 2017-06-14 | 新型吡啶酮羧酸衍生物或其盐 |
CA3027827A CA3027827A1 (en) | 2016-06-15 | 2017-06-14 | Novel pyridonecarboxylic acid derivative or salt thereof |
Applications Claiming Priority (4)
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JP2016118484 | 2016-06-15 | ||
JP2016-118484 | 2016-06-15 | ||
JP2017-056474 | 2017-03-22 | ||
JP2017056474 | 2017-03-22 |
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WO2017217441A1 true WO2017217441A1 (ja) | 2017-12-21 |
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PCT/JP2017/021899 WO2017217441A1 (ja) | 2016-06-15 | 2017-06-14 | 新規ピリドンカルボン酸誘導体又はその塩 |
Country Status (10)
Country | Link |
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US (1) | US10532984B2 (ja) |
EP (1) | EP3473616A4 (ja) |
JP (1) | JP6322772B1 (ja) |
KR (1) | KR20190016962A (ja) |
CN (1) | CN109311818A (ja) |
AU (1) | AU2017285689B2 (ja) |
BR (1) | BR112018076175A2 (ja) |
CA (1) | CA3027827A1 (ja) |
MX (1) | MX2018015462A (ja) |
WO (1) | WO2017217441A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108250087A (zh) * | 2018-03-15 | 2018-07-06 | 常州大学 | 一种4-异丁氧基苄胺的合成方法 |
Families Citing this family (1)
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CN109851557B (zh) * | 2019-03-11 | 2021-01-01 | 江西富祥药业股份有限公司 | 一种西他沙星有关物质d-3的制备方法 |
Citations (5)
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JPS6056959A (ja) * | 1983-07-18 | 1985-04-02 | アボツト ラボラトリ−ズ | キノリン抗菌性化合物 |
US4762845A (en) * | 1986-05-21 | 1988-08-09 | Abbott Laboratories | 7-(3-Substituted imino-1-pyrrolidinyl)-quinolone-3-carboxylic acids |
JPH037260A (ja) * | 1989-03-31 | 1991-01-14 | Wakunaga Pharmaceut Co Ltd | 新規キノロン誘導体またはその塩及びこれを含有する抗菌剤 |
WO1996023775A1 (fr) * | 1995-01-30 | 1996-08-08 | Wakunaga Seiyaku Kabushiki Kaisha | Nouveaux derives d'acide pyridonecarboxylique ou de ses sels et agent antibacterien contenant ces derives en tant qu'ingredient actif |
WO1997040036A1 (fr) * | 1996-04-19 | 1997-10-30 | Wakunaga Pharmaceutical Co., Ltd. | Nouveaux derives de l'acide pyridonocarboxylique ou des sels de cet acide et agents antibacteriens contenant ces substances en tant que composant actif |
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JPS5534144A (en) | 1978-08-31 | 1980-03-10 | Yuasa Battery Co Ltd | Separator element |
JPS5710109A (en) | 1980-06-20 | 1982-01-19 | Nippon Kogaku Kk <Nikon> | Two-group constitution ftheta lens system |
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JPS6362510A (ja) | 1986-09-03 | 1988-03-18 | Kurita Mach Mfg Co Ltd | フイルタプレスの濾過体 |
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WO1996012704A1 (fr) | 1994-10-20 | 1996-05-02 | Wakunaga Seiyaku Kabushiki Kaisha | Nouveau derive de pyridone-carboxylate, ou sel de celui-ci, et antibacterien le contenant comme principe actif |
MX2007005892A (es) * | 2004-11-17 | 2007-06-19 | Wakunaga Pharma Co Ltd | Derivados de acido piridonacarboxilico novedosos y sales de los mismos. |
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2017
- 2017-06-14 KR KR1020187035735A patent/KR20190016962A/ko active Search and Examination
- 2017-06-14 JP JP2017545766A patent/JP6322772B1/ja not_active Expired - Fee Related
- 2017-06-14 MX MX2018015462A patent/MX2018015462A/es active IP Right Grant
- 2017-06-14 CA CA3027827A patent/CA3027827A1/en not_active Abandoned
- 2017-06-14 CN CN201780037381.2A patent/CN109311818A/zh active Pending
- 2017-06-14 WO PCT/JP2017/021899 patent/WO2017217441A1/ja unknown
- 2017-06-14 EP EP17813336.9A patent/EP3473616A4/en not_active Withdrawn
- 2017-06-14 AU AU2017285689A patent/AU2017285689B2/en not_active Ceased
- 2017-06-14 BR BR112018076175-3A patent/BR112018076175A2/pt not_active Application Discontinuation
- 2017-06-14 US US16/308,292 patent/US10532984B2/en not_active Expired - Fee Related
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JPH037260A (ja) * | 1989-03-31 | 1991-01-14 | Wakunaga Pharmaceut Co Ltd | 新規キノロン誘導体またはその塩及びこれを含有する抗菌剤 |
WO1996023775A1 (fr) * | 1995-01-30 | 1996-08-08 | Wakunaga Seiyaku Kabushiki Kaisha | Nouveaux derives d'acide pyridonecarboxylique ou de ses sels et agent antibacterien contenant ces derives en tant qu'ingredient actif |
WO1997040036A1 (fr) * | 1996-04-19 | 1997-10-30 | Wakunaga Pharmaceutical Co., Ltd. | Nouveaux derives de l'acide pyridonocarboxylique ou des sels de cet acide et agents antibacteriens contenant ces substances en tant que composant actif |
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Cited By (2)
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CN108250087A (zh) * | 2018-03-15 | 2018-07-06 | 常州大学 | 一种4-异丁氧基苄胺的合成方法 |
CN108250087B (zh) * | 2018-03-15 | 2020-06-30 | 常州大学 | 一种4-异丁氧基苄胺的合成方法 |
Also Published As
Publication number | Publication date |
---|---|
CN109311818A (zh) | 2019-02-05 |
AU2017285689A1 (en) | 2019-01-03 |
US10532984B2 (en) | 2020-01-14 |
BR112018076175A2 (pt) | 2019-03-26 |
US20190276407A1 (en) | 2019-09-12 |
CA3027827A1 (en) | 2017-12-21 |
JPWO2017217441A1 (ja) | 2018-07-05 |
EP3473616A4 (en) | 2020-02-19 |
AU2017285689B2 (en) | 2021-01-07 |
MX2018015462A (es) | 2019-05-27 |
KR20190016962A (ko) | 2019-02-19 |
JP6322772B1 (ja) | 2018-05-09 |
EP3473616A1 (en) | 2019-04-24 |
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