BR112018076175A2 - novo derivado de ácido piridonacarboxílico ou sal deste - Google Patents
novo derivado de ácido piridonacarboxílico ou sal desteInfo
- Publication number
- BR112018076175A2 BR112018076175A2 BR112018076175-3A BR112018076175A BR112018076175A2 BR 112018076175 A2 BR112018076175 A2 BR 112018076175A2 BR 112018076175 A BR112018076175 A BR 112018076175A BR 112018076175 A2 BR112018076175 A2 BR 112018076175A2
- Authority
- BR
- Brazil
- Prior art keywords
- group
- hydrogen atom
- lower alkyl
- salt
- acid derivative
- Prior art date
Links
- YSLIPUSJNFIFAB-UHFFFAOYSA-N 2-oxopyridine-1-carboxylic acid Chemical class OC(=O)N1C=CC=CC1=O YSLIPUSJNFIFAB-UHFFFAOYSA-N 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003277 amino group Chemical group 0.000 abstract 4
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000193163 Clostridioides difficile Species 0.000 abstract 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- 241000191967 Staphylococcus aureus Species 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960003085 meticillin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
são fornecidos um novo derivado do ácido piridonacarboxílico ou um sal deste tendo um excelente efeito em bactérias tais como staphylococcus aureus, pseudomonas aeruginosa e clostridium difficile resistentes à meticilina e não sendo suscetível a bombas de efluxo de fármacos, e um agente antimicrobiano compreendendo o mesmo. um derivado do ácido piridonacarboxílico representado pela fórmula (1), em que r1 é um átomo de hidrogênio, um átomo de halogênio, um grupo alquila inferior ou um grupo amino; r2 é um grupo -nh-r6, em que r6 é um átomo de hidrogênio, um grupo alquila inferior, um grupo alquila inferior amino ou semelhantes; um grupo -o-r7, em que r7 é um átomo de hidrogênio, um grupo alquila inferior ou semelhantes; um grupo -(ch2)m-r8, em que r8 é um grupo amino ou semelhantes e m é um número inteiro de 1 a 4); ou um grupo amino cíclico representado pela seguinte fórmula (2), em que y representa nh ou c-r9ar9b, em que r9a e r9b são independentemente átomo de hidrogênio, um grupo alquila inferior, um grupo amino, um grupo amino alquila inferior ou semelhantes; e n e p são um número inteiro de 1 ou 2; r3 é um átomo de hidrogênio, um átomo de halogênio, um grupo alquila inferior ou semelhantes; r4 é um átomo de hidrogênio ou um grupo carboxila-grupo protetor; e r5 é um átomo de hidrogênio ou um grupo hidroxila-grupo protetor; ou um sal deste.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016118484 | 2016-06-15 | ||
JP2016-118484 | 2016-06-15 | ||
JP2017-056474 | 2017-03-22 | ||
JP2017056474 | 2017-03-22 | ||
PCT/JP2017/021899 WO2017217441A1 (ja) | 2016-06-15 | 2017-06-14 | 新規ピリドンカルボン酸誘導体又はその塩 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018076175A2 true BR112018076175A2 (pt) | 2019-03-26 |
Family
ID=60664281
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018076175-3A BR112018076175A2 (pt) | 2016-06-15 | 2017-06-14 | novo derivado de ácido piridonacarboxílico ou sal deste |
Country Status (10)
Country | Link |
---|---|
US (1) | US10532984B2 (pt) |
EP (1) | EP3473616A4 (pt) |
JP (1) | JP6322772B1 (pt) |
KR (1) | KR20190016962A (pt) |
CN (1) | CN109311818A (pt) |
AU (1) | AU2017285689B2 (pt) |
BR (1) | BR112018076175A2 (pt) |
CA (1) | CA3027827A1 (pt) |
MX (1) | MX2018015462A (pt) |
WO (1) | WO2017217441A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108250087B (zh) * | 2018-03-15 | 2020-06-30 | 常州大学 | 一种4-异丁氧基苄胺的合成方法 |
CN109851557B (zh) * | 2019-03-11 | 2021-01-01 | 江西富祥药业股份有限公司 | 一种西他沙星有关物质d-3的制备方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53141286A (en) | 1977-05-16 | 1978-12-08 | Kyorin Seiyaku Kk | Novel substituted quinolinecarboxylic acid |
JPS5534144A (en) | 1978-08-31 | 1980-03-10 | Yuasa Battery Co Ltd | Separator element |
JPS5710109A (en) | 1980-06-20 | 1982-01-19 | Nippon Kogaku Kk <Nikon> | Two-group constitution ftheta lens system |
JPS6056959A (ja) * | 1983-07-18 | 1985-04-02 | アボツト ラボラトリ−ズ | キノリン抗菌性化合物 |
NZ208470A (en) | 1983-07-18 | 1988-06-30 | Abbott Lab | 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such |
JPS6111955A (ja) | 1984-06-27 | 1986-01-20 | Matsushita Electric Ind Co Ltd | 磁気記録再生装置 |
US4762845A (en) * | 1986-05-21 | 1988-08-09 | Abbott Laboratories | 7-(3-Substituted imino-1-pyrrolidinyl)-quinolone-3-carboxylic acids |
JPS6352510A (ja) | 1986-08-22 | 1988-03-05 | Toshiba Corp | 電子同調チユ−ナ |
JPS6362510A (ja) | 1986-09-03 | 1988-03-18 | Kurita Mach Mfg Co Ltd | フイルタプレスの濾過体 |
US5153203A (en) | 1989-03-30 | 1992-10-06 | Wakunaga Seiyaku Kabushiki Kaisha | Quinolone derivatives and salts thereof, preparation processes thereof, and antibacterial agents containing the same |
JPH037260A (ja) * | 1989-03-31 | 1991-01-14 | Wakunaga Pharmaceut Co Ltd | 新規キノロン誘導体またはその塩及びこれを含有する抗菌剤 |
WO1996012704A1 (fr) | 1994-10-20 | 1996-05-02 | Wakunaga Seiyaku Kabushiki Kaisha | Nouveau derive de pyridone-carboxylate, ou sel de celui-ci, et antibacterien le contenant comme principe actif |
WO1996023775A1 (fr) * | 1995-01-30 | 1996-08-08 | Wakunaga Seiyaku Kabushiki Kaisha | Nouveaux derives d'acide pyridonecarboxylique ou de ses sels et agent antibacterien contenant ces derives en tant qu'ingredient actif |
EP0897919B1 (en) * | 1996-04-19 | 2004-06-16 | Wakunaga Pharmaceutical Co., Ltd. | Novel pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents containing the same as the active ingredient |
MX2007005892A (es) * | 2004-11-17 | 2007-06-19 | Wakunaga Pharma Co Ltd | Derivados de acido piridonacarboxilico novedosos y sales de los mismos. |
-
2017
- 2017-06-14 KR KR1020187035735A patent/KR20190016962A/ko active Search and Examination
- 2017-06-14 JP JP2017545766A patent/JP6322772B1/ja not_active Expired - Fee Related
- 2017-06-14 MX MX2018015462A patent/MX2018015462A/es active IP Right Grant
- 2017-06-14 CA CA3027827A patent/CA3027827A1/en not_active Abandoned
- 2017-06-14 CN CN201780037381.2A patent/CN109311818A/zh active Pending
- 2017-06-14 WO PCT/JP2017/021899 patent/WO2017217441A1/ja unknown
- 2017-06-14 EP EP17813336.9A patent/EP3473616A4/en not_active Withdrawn
- 2017-06-14 AU AU2017285689A patent/AU2017285689B2/en not_active Ceased
- 2017-06-14 BR BR112018076175-3A patent/BR112018076175A2/pt not_active Application Discontinuation
- 2017-06-14 US US16/308,292 patent/US10532984B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN109311818A (zh) | 2019-02-05 |
AU2017285689A1 (en) | 2019-01-03 |
US10532984B2 (en) | 2020-01-14 |
US20190276407A1 (en) | 2019-09-12 |
CA3027827A1 (en) | 2017-12-21 |
WO2017217441A1 (ja) | 2017-12-21 |
JPWO2017217441A1 (ja) | 2018-07-05 |
EP3473616A4 (en) | 2020-02-19 |
AU2017285689B2 (en) | 2021-01-07 |
MX2018015462A (es) | 2019-05-27 |
KR20190016962A (ko) | 2019-02-19 |
JP6322772B1 (ja) | 2018-05-09 |
EP3473616A1 (en) | 2019-04-24 |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |