WO2017104144A1 - マイクロニードル及びマイクロニードルパッチ - Google Patents
マイクロニードル及びマイクロニードルパッチ Download PDFInfo
- Publication number
- WO2017104144A1 WO2017104144A1 PCT/JP2016/005166 JP2016005166W WO2017104144A1 WO 2017104144 A1 WO2017104144 A1 WO 2017104144A1 JP 2016005166 W JP2016005166 W JP 2016005166W WO 2017104144 A1 WO2017104144 A1 WO 2017104144A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- layer
- drug
- microneedle
- containing layer
- intermediate layer
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Definitions
- the present invention relates to a microneedle and a microneedle patch that improve the targeting and administration efficiency of drug administration in a microneedle for percutaneously reaching a predetermined drug in the dermis.
- microneedles have been increasingly used in the fields related to medicine, beauty and health, and regenerative medicine. Specifically, using a microneedle patch having a certain size in which a plurality of microneedles are arranged, for example, a target drug, vaccine, etc. from the body surface such as human skin, mucous membrane, etc. Attempts have been made to administer it.
- Patent Document 1 As a method for producing such a microneedle, for example, a method (Patent Document 1) in which a needle-shaped material having a plurality of recesses is filled with a needle forming material using a squeegee, and then dried and cured (Patent Document 1), An ink jet method in which a droplet of a microneedle forming material is ejected by computer control using a jet part for an ink jet printer to a female type having a concave part, filled into the female type, and then dried and cured (Patent Document 2) and the like are known.
- Patent Document 2 An ink jet method in which a droplet of a microneedle forming material is ejected by computer control using a jet part for an ink jet printer to a female type having a concave part, filled into the female type, and then dried and cured
- microneedles The purpose of drug administration with microneedles is (1) targeting the dermis itself, (2) administering the drug to the region of the capillary network of the dermal papillary layer where blood flow is abundant, and Examples include absorption of a drug from a blood vessel and administration into a blood vessel throughout the body, and (3) expectation of an immune action by administration to the boundary between the epidermis and dermis.
- microneedles there are practical examples of microneedles that actually specialize in each field, efficiently administer drugs to target sites, and develop therapeutic effects. The manufacturing method has not been established yet.
- An object of the present invention is to provide a microneedle and a microneedle patch that are specialized for individual therapeutic purposes and can efficiently express a therapeutic effect.
- the present inventors have intensively studied to solve the above problems, and are microneedles sequentially including a drug-containing layer, an intermediate layer, and a basal layer from the distal end side, and a boundary portion between the drug-containing layer and the intermediate layer is provided.
- the microneedle which has a shape swelled to the middle layer side, finds that the drug can be efficiently released limited to the targeted site in the dermis of the skin and that the time can be accurately controlled.
- the invention has been completed.
- the present invention is as follows.
- a microneedle comprising a drug-containing layer, an intermediate layer, and a basal layer sequentially from the tip side, The said microneedle characterized by the boundary part of a chemical
- (6) The microneedle according to any one of (1) to (5) above, wherein the tensile strength of the intermediate layer is lower than the tensile strength of the drug-containing layer and the tensile strength of the base layer.
- (7) The microneedle according to (6) above, wherein the tensile strength of the intermediate layer is 0.9 times or less of the tensile strength of the drug-containing layer and the tensile strength of the base layer.
- (8) The microneedle according to any one of (1) to (7) above, wherein a boundary portion between the intermediate layer and the basal layer is flat or swelled toward the intermediate layer.
- the shape of each boundary part of the drug-containing layer, the intermediate layer, and the base layer is controlled by the viscosity of the microneedle forming material, the surface activity, and / or the water repellency of the concave master surface, The microneedle according to any one of (1) to (9) above.
- a partition wall made of a poorly soluble polymer-forming material is further provided around the drug-containing layer, The partition wall prevents the drug-containing layer from being crushed when the microneedle is driven, and the drug-containing layer is placed in a concentrated manner at a target site and delayed for a predetermined time.
- the microneedle according to any one of the above (1) to (18), wherein the microneedle is released.
- the release start time and the release time of the drug are controlled, and the programmed sustained release of the drug
- the microneedle which can be appropriately indwelled in the epidermis and a specific site
- microneedle preparation It is a figure which shows surface tension and a contact angle. It is a figure which shows the shape of the boundary part at the time of microneedle preparation. It is a figure which shows the state after driving in the microneedles 5, 6, and 7 for dermal papillary layer treatment, microneedles 8, 9, and 10 for dermal papillary layer treatment, and microneedle 11 for epidermis and dermis upper layer. For convenience, the fracture surface of the intermediate layer is shown as a plane. It is a figure which shows the preparation method (upper stage) and the use condition (lower stage) of the microneedle 5 for dermal papilla lower layer treatment.
- FIG. A has a flat fracture surface
- B has a concave central portion of the fracture surface
- C has a central portion of the fracture surface protruding.
- FIG. A has a flat fracture surface
- B has a concave central portion of the fracture surface
- C has a central portion of the fracture surface protruding.
- the present invention relates to a microneedle for transdermal administration of a drug, comprising a drug-containing layer, an intermediate layer and a basal layer in this order from the tip side, and the boundary between the drug-containing layer and the intermediate layer is on the intermediate layer side
- the present invention relates to a microneedle characterized by having a bulging shape.
- the microneedle patch having the microneedle of the present invention on the substrate to the skin and removing the substrate from the skin, the microneedle is easily broken at the intermediate layer, and the drug-containing layer is reliably placed at the target site.
- the boundary between the intermediate layer and the base layer may be flat, or may have a shape bulging toward the intermediate layer side or the base layer side.
- the intermediate layer is designed in the shape of a concave lens.
- the middle portion of the intermediate layer may be an extremely thin layer, or the base layer may be in direct contact with the drug-containing layer in the middle portion of the intermediate layer.
- the intermediate layer has a thick ring shape on the outer side, and the inner diameter is preferably 5 ⁇ m or more, more preferably 10 ⁇ m or more, and further preferably 50 ⁇ m or more.
- the microneedle of the present invention further includes a tip layer not containing a drug on the tip side of the drug-containing layer in order to control the position and shape of the drug-containing layer, the release time of the drug, and improve penetrability. Also good.
- the microneedle of the present invention may be manufactured using any known method. For example, a concave master having a plurality of concave portions having the shape of a microneedle is prepared, and a dispenser, an ink jet device, a squeegee, etc. are provided on the concave master. And a method of filling the microneedle forming material using
- the material for forming the tip layer, the drug-containing layer, and the intermediate layer of the microneedle of the present invention is not particularly limited as long as it can be decomposed in the body after being implanted into the skin and release the drug, for example, gluten, Proteins such as gelatin, polysaccharides such as hyaluronic acid, chondroitin sulfate, alginic acid, starch, dextran, polylactic acid, polyglycolic acid, lactic acid / glycolic acid copolymer, polycaprolactone, polyhydroxybutyrate, polyethylene glycol, polypropylene glycol, etc.
- gluten for example, gluten, Proteins such as gelatin, polysaccharides such as hyaluronic acid, chondroitin sulfate, alginic acid, starch, dextran, polylactic acid, polyglycolic acid, lactic acid / glycolic acid copolymer, polycaprolactone, polyhydroxybutyrate, polyethylene glycol, polyprop
- the biodegradable polymer selected may be mentioned, and it may be one that allows sustained release of the drug by polymerizing with the drug and controlling the solubility of the biodegradable polymer.
- the base layer may be formed of the biodegradable forming material or a non-biodegradable forming material.
- the tensile strength of the intermediate layer is preferably lower than the tensile strength of the drug-containing layer and the base layer, for example, 0.9 times or less the tensile strength of the drug-containing layer and the base layer, 0.8 Double or less, 0.7 or less, 0.6 or less, or 0.5 or less.
- the intermediate layer is preferably formed of a material that is less soluble in the body than the drug-containing layer, and the intermediate layer formed of such a material diffuses the drug to a site other than the target site in the body. It works as a partition wall.
- the thickness of the intermediate layer is preferably 50 to 200 ⁇ m, more preferably 80 to 160 ⁇ m, even more preferably 100 to 150 ⁇ m at the peripheral edge of the microneedle, and preferably 50 ⁇ m or less than 50 ⁇ m, more preferably at the center of the microneedle. Is 30 ⁇ m or less, more preferably 10 ⁇ m or less, and may be 0 ⁇ m.
- the drug contained in the drug-containing layer is not particularly limited, for example, antidiabetic agents, antihypertensive agents, anticancer agents, antiallergic agents, hormones, growth factors, vaccines, analgesics such as morphine, analgesic / antiinflammatory agents, Examples include osteoporosis treatment agents, anemia treatment agents, high cholesterol treatment agents, biological preparations, gene therapy agents, emergency treatment agents such as adrenaline, allergen test substances, and the like.
- a drug requiring subcutaneous injection can be preferably exemplified.
- the content of the drug can be appropriately determined according to the type and form of the drug and taking into consideration sustained release properties.
- the shape of the drug-containing layer and the site from the tip can be freely changed by changing the boundary between the tip layer and the drug-containing layer, the boundary between the drug-containing layer and the intermediate layer, the length of the tip layer and the drug-containing layer, etc. It can be controlled, and can be exemplified by rod shape, triangular pyramid shape, inverted truncated cone shape, inverted truncated pyramid shape, spindle shape, umbrella shape, dumbbell shape, spherical shape, circular flat plate shape, etc. Is not limited to these.
- the shorter the drug-containing layer is in the vertical direction the smaller the surface area of the side surface, which is advantageous for sustained drug release, and the administration of a drug limited to a narrow site such as the dermal papilla layer is possible.
- each boundary portion of the tip layer, the drug-containing layer, the intermediate layer, and the basal layer is, for example, when forming a microneedle by sequentially overlaying a forming material on a concave master and a concave material It is determined by the contact angle 1 with the original plate (FIG. 1), and the contact angle 1 depends on the viscosity of the forming material, the surface activity, and / or the water repellency of the concave original plate surface.
- FIG. 2 shows a state 2 where the boundary portion is flat, a protruding state 3 and a depressed state 4.
- the boundary portion has a shape bulging toward the tip side, and if it is low, the boundary portion has a shape bulging toward the base layer side. Further, the higher the viscosity of the forming material injected into the concave master first, the more the boundary swells toward the base layer side.
- the shape of the boundary can also be controlled by the material of the concave master, and the more the concave master is made of a highly water-repellent material, the easier it is to have a shape with a large contact angle 1 where the boundary swells toward the base layer side, and the water repellency is low
- the more the material is made the more the shape of the boundary becomes concave and the contact angle 1 becomes 0 or minus.
- Any material can be used as the material of the concave original, and silicon, plastic, and metal can be preferably exemplified. Further, the surface of the concave original plate may be subjected to water repellent processing or hydrophilic processing as necessary.
- the shape of the boundary portion can be controlled more precisely by controlling the amount of dripping, the dripping site, and the interval of the dripping in addition to the viscosity and surface activity of the forming material. Can do. Further, by controlling the drying and curing interval according to the purpose of use of the microneedles, it is possible to produce a shape optimal for that purpose.
- the surface activity of the microneedle forming material can be controlled by adding a surfactant to the forming material.
- the surfactant that can be used in the present invention may be any surfactant that can be added to pharmaceuticals, such as nonionic surfactants, anionic surfactants, and cationic surfactants. And amphoteric surfactants.
- the viscosity of the microneedle forming material can be controlled by adding a thickener or a viscosity reducing agent to the forming material.
- the thickener that can be used in the present invention may be any thickener that can be added to pharmaceuticals.
- monosaccharides such as sucrose and glucose, disaccharides and oligosaccharides, pectin
- Mention may be made of polysaccharides such as carrageenan, guar gum, locust bean gum, tamarind gum, xanthan gum, curdlan, chondroitin sulfate, alginic acid, starch, dextran, and proteins such as gluten and gelatin.
- the viscosity reducing agent that can be used in the present invention may be any viscosity reducing agent that can be added to pharmaceuticals, and examples thereof include lower alcohols such as urea and ethanol, and emulsifiers. Further, the viscosity can be reduced by reducing the concentration of the forming material.
- the coating time of the drug in the body can be controlled by coating the drug-containing layer with a poorly soluble polymer-forming material having a lower solubility in the body than the drug-containing layer.
- the coating of the drug-containing layer is made by forming the tip layer and the intermediate layer adjacent to the drug-containing layer with a hardly soluble polymer forming material. It can be performed by a method such as coating.
- microneedles are manufactured by sequentially overlaying the forming material on the concave master, after spraying and drying the tip layer forming material, spray or apply the sparingly soluble polymer forming material on the top of the tip layer and the wall surface of the concave master.
- the drug-containing layer forming material is injected into the central part of the concave original plate and dried, and further layered with a poorly soluble polymer forming material, whereby the drug-containing layer is formed with a hardly soluble polymer forming material.
- the affinity between the hardly soluble polymer forming material and the concave original plate is increased, and the coating of the drug-containing layer is facilitated.
- the drug-containing layer may be only one layer or two or more layers.
- the drugs contained may be the same or two or more different drugs, and adjacent drug-containing layers are separated by a boundary layer containing no drug. It may be done.
- the same or different drugs can be released with a time difference, and time difference drugs with two or more kinds of drugs contained Microneedle capable of therapy can be made.
- the hardness of the tip layer is preferably higher than that of the drug-containing layer, for example, 1.1 times or more, 1.2 times or more, 1.3 times or more, 1.4 times or more of the hardness of the drug-containing layer. Double or more, 1.5 or more times.
- the material used for forming the tip layer may be the same as or different from the material for forming the drug-containing layer excluding the drug. In this case, the hardness of the tip layer not containing the drug is determined by It becomes high compared with the medicine containing layer containing. Further, the hardness of the tip layer may be increased by adding a curing agent to the forming material.
- the drying degree of only the tip layer may be lengthened to increase the degree of drying.
- the hardness can be increased and the radius of curvature of the tip can be reduced.
- the tip may be pulled and stretched to reduce the radius of curvature.
- the radius of curvature of the tip of the microneedle of the present invention is preferably 10 ⁇ m or less, more preferably 7 ⁇ m or less, further preferably 5 ⁇ m or less, and particularly preferably 3 ⁇ m or less.
- the cross section of the tip layer is not limited to a circle, and may be processed into an ellipse, triangle, quadrangle, + shape, * shape, etc.
- a spiral groove is continuously formed on the outside of the microneedle so that the microneedle can be rotated by driving, thereby facilitating driving of the microneedle and promoting breakage of the microneedle in the intermediate layer. Can do.
- the outer surface of the microneedle of the present invention has a smooth surface and is hardened to improve penetration, so that proteins such as gluten and gelatin, polysaccharides such as chondroitin sulfate, alginic acid, starch and dextran, polylactic acid and polyglycolic acid , Lactic acid / glycolic acid copolymer, polycaprolactone, polyhydroxybutyrate, polyethylene glycol, polypropylene glycol, biodegradable polymer selected from silicon compounds, amphoteric, anionic, cationic, and nonionic You may coat
- surfactant selected from surfactant, ethyl alcohol, physiological saline, water, etc.
- Coating with the coating material can be performed using any known technique, and examples thereof include a dip coating method, an ink jet method, and a spray coating method.
- the thickness of the coating include 10 ⁇ m or less, preferably 5 ⁇ m or less, and more preferably 3 ⁇ m or less.
- the frictional resistance is preferably reduced by 5% or more, more preferably reduced by 10% or more, and particularly preferably reduced by 20% or more compared to before the coating with the coating material.
- it may be coated with a coating material whose solubility in the body is lower than that of the drug-containing layer.
- the coating material is desirably a material that can improve the penetrability of the microneedles and maintain the sharpness of the microneedles during the storage period from manufacture to use.
- the curing agent in the present invention means a material that can increase the hardness of the microneedle, for example, calcium chloride, sodium chloride, polysaccharide, hyaluronic acid, chondroitin sulfate, carboxy polymer, polyacrylic acid, polylactic acid, Examples thereof include hydroxyapatite, polyethylene glycol, fluorine-based compounds, silicon-based compounds and the like.
- These curing agents may be added to the forming material of the microneedle or may be added to the coating material, and the amount of the curing agent can be appropriately set according to the kind of the curing agent and the purpose of use.
- the curing agent is a solid material
- the curing agent is a material that can improve the shape retention of the microneedles and can maintain the sharpness during the storage period from manufacture to use.
- the total length of the microneedle of the present invention can be determined according to the purpose of drug administration.
- the total length of the microneedle is preferably 400 to 1000 ⁇ m, more preferably 450 to 800 ⁇ m, More preferably, it is 500 to 650 ⁇ m.
- the total length of the microneedle is preferably 100 to 600 ⁇ m, more preferably 150 to 500 ⁇ m, and even more preferably 200 to 450 ⁇ m so that the drug can be administered to the lower nipple portion.
- the total length of the microneedle is preferably 50 to 300 ⁇ m, more preferably 100 to 250 ⁇ m so that the drug can be administered to the boundary between the epidermis and dermis.
- 150 to 200 ⁇ m is more preferable.
- the diameter of the base portion, the major axis, and the length of the long side are preferably 30 to 1000 ⁇ m, more preferably 150 to 500 ⁇ m, and further preferably 200 to 350 ⁇ m.
- the microneedle patch means a patch having a plurality of microneedles on a substrate.
- proteins such as gluten and gelatin, polysaccharides such as chondroitin sulfate, alginic acid, starch and dextran, polylactic acid, polyglycolic acid, lactic acid / glycolic acid copolymer, polycaprolactone, polyhydroxybutyrate, polyethylene Biodegradable polymers selected from glycol, polypropylene glycol, etc., polyolefins such as polyethylene and polypropylene, biodegradable polymers selected from polystyrene, polyester, polyurethane, polyamide, fluororesin, paper, non-woven fabric, A sheet made of cloth can be exemplified.
- the microneedle patch of the present invention may have an adhesive surface, or may be a structure in which the substrate and the base layer are integrated. By setting it as such a structure, the reliable fracture
- FIG. 3 is a diagram showing a state after driving a microneedle according to the purpose of treatment into the dermis.
- the microneedles 5, 6, and 7 are microneedles for treating the dermal papillary layer 104
- the microneedles 8, 9, and 10 are microneedles intended to absorb a drug from the capillary network 106 of the dermal papillary layer 103.
- the microneedle 11 is a microneedle for administering a drug to the boundary between the epidermis and dermis.
- the microneedles 5, 6, and 7, the microneedles are driven so that the drug-containing layer 14 reaches deep into the dermis beyond the dermal papilla layer.
- the microneedles 8, 9, and 10 deliver the drug-containing layer 14 accurately to the dermal papillary layer 103 for the purpose of systemically administering the drug through the capillary network 106 existing in the dermal papillary layer 103.
- the microneedle 11 can deliver a drug for the purpose of inducing an immune reaction by confining the drug around the boundary between the epidermis 102 and the dermal papilla layer 103, or for the purpose of allergen testing.
- FIG. 4 is a diagram showing a method for producing the microneedle 5 for the treatment of the lower layer of the dermal papillae by the ink jet method.
- a drug-containing layer 14 with a protruding boundary is prepared.
- the pointed portion is dried and cured, and subsequently, the intermediate layer forming material 15 having a low surface tension and a surface active action is discharged to form the intermediate layer 16 having a recessed boundary portion.
- the base layer forming material 17 is discharged and integrated with the substrate to produce the base layer 18.
- the lower part of FIG. 4 is a diagram showing treatment with the microneedles 5.
- a microneedle patch having microneedles 5 is driven into the skin using an impact applicator or the like, fracture surfaces 19a and 19b are formed in the intermediate layer 16, and when the microneedle patch is removed, the drug-containing layer 14 and a part of the intermediate layer are formed. Only 20 are placed in the lower layer of the dermal papilla. Thereafter, the drug is released from the drug-containing layer 14 as indicated by 22.
- part 20 of the intermediate layer exists on the epidermis side of the drug-containing layer 14 and dissolves later than the drug-containing layer 14 until the insertion part 21 is closed, the dermis rich in blood vessels of the drug is contained. It prevents diffusion to the nipple layer and leakage from the insertion part 21.
- FIG. 5 is a diagram showing a method for producing the microneedle 6 for treating the dermal papillary sublayer by the ink jet method.
- a drug-containing layer 14 with a protruding boundary is prepared.
- the discharge is continuously repeated at the center of the boundary part of the drug-containing layer forming material 13 to project the boundary part greatly, and the shape of the drug-containing layer on the intermediate layer side is made into a semi-conical shape.
- the drug-containing layer 14 is dried and cured, and subsequently, an intermediate layer forming material 15 having a low surface tension and a surface active action is discharged to form the intermediate layer 16 having a recessed boundary portion. Further, the substrate is dried and cured, and the base layer forming material 17 is discharged and integrated with the substrate to produce the base layer 18.
- FIG. 5B is a diagram showing treatment with the microneedle 6.
- a microneedle patch having microneedles 6 is driven into the skin using an impact applicator or the like, fracture surfaces 19a and 19b are formed in the intermediate layer 16, and when the microneedle patch is removed, the drug-containing layer 14 and a part of the intermediate layer are formed. Only 20 are placed in the lower layer of the dermal papilla. Thereafter, the drug is released from the drug-containing layer 14 as indicated by 22.
- part 20 of the intermediate layer exists on the epidermis side of the drug-containing layer 14 and dissolves later than the drug-containing layer 14 until the insertion part 21 is closed, the dermis rich in blood vessels of the drug is contained. It prevents diffusion to the nipple layer and leakage from the insertion part 21.
- the upper part of FIG. 6 is a diagram showing a method for producing the microneedle 9 for treating the dermal papillary layer by the ink jet method.
- the tip layer 24 having a recessed boundary is produced by repeatedly discharging the tip layer forming material 23 having a low viscosity and a high surface activity to the concave master 12 for producing microneedles. After the boundary portion where the center is recessed is dried and cured, the drug-containing layer forming material 25 having a high viscosity and containing a drug is discharged to form the drug-containing layer 26 in which the boundary portion protrudes. Then, the intermediate layer forming material 15 having a low surface tension and having a surface activity is discharged to form the intermediate layer 16 having a recessed boundary. Further, the base layer forming material 17 is discharged and integrated with the substrate to produce the base layer 18. At that time, controlled release can be realized by controlling the solubility of the drug-containing layer 26.
- FIG. 6 The lower part of FIG. 6 is a diagram showing treatment with the microneedle 9.
- a microneedle patch provided with microneedles 9 is driven into the skin using an impact applicator or the like, fracture surfaces 19a and 19b are formed in the intermediate layer 16, and when the microneedle patch is removed, a tip layer 24, a drug-containing layer 26, A portion 20 of the intermediate layer is placed in the dermal papilla layer. Thereafter, the tip layer 24 dissolves at an early stage as indicated by 27, and the drug is released from the drug-containing layer 26 as indicated by 28. At this time, until the insertion part 21 is closed, a part 20 of the intermediate layer exists on the epidermis side of the drug-containing layer 26 and dissolves later than the drug-containing layer 26.
- the administered drug is absorbed into blood vessels throughout the body, enabling efficient treatment.
- a tip layer forming material 23 having a low viscosity and a high surface activity instead of the tip layer forming material 23 having a low viscosity and a high surface activity, a tip layer forming material having a moderate viscosity and having no surface activity is used.
- the microneedle 8 provided with the layer 24 can be produced.
- FIG. 7 is a diagram showing a method for producing the microneedle 10 for the dermal papilla layer, in which the drug-containing layer 26 is covered with a partition wall 30 made of a poorly soluble polymer-forming material, by an inkjet method.
- the tip layer forming material 23 having a low viscosity and a high surface activity to the concave mold 12 for producing microneedles
- the tip portion 24 having a recessed boundary portion is produced.
- the hardly soluble polymer forming material 29 is discharged by discharging the hardly soluble polymer forming material 29 having a moderate to high surface activity and a slow dissolution rate in the body.
- the lower half of the partition wall 30 is made. Further, a drug-containing layer forming material 25 having a high viscosity and containing a drug is discharged to form a drug-containing layer 26 with a protruding boundary. Subsequently, the poorly soluble polymer forming material 29 having a moderate to high surface activity and a slow dissolution rate in the body is discharged to produce the upper half of the partition wall 30 made of the hardly soluble polymer forming material. Then, the intermediate layer forming material 15 having a low surface tension and having a surface activity is discharged to form the intermediate layer 16 having a recessed boundary. Further, the base layer forming material 17 is discharged and integrated with the substrate to produce the base layer 18.
- FIG. 8 is a diagram showing treatment with the microneedle 10.
- the microneedle patch provided with the microneedle 10 is driven into the skin using an impact applicator or the like, the fracture surface 19a, 19b is formed in the intermediate layer 16, and when the microneedle patch is removed, the tip layer 24, the hardly soluble polymer is formed.
- the drug-containing layer 26 covered with the partition wall 30 made of the material and a part 20 of the intermediate layer are placed in the dermal papilla layer.
- the solubility of the drug-containing layer 26 and the solubility of the partition wall 30 made of a poorly soluble polymer-forming material both the drug release start time and the release time from the drug-containing layer 26 are controlled. Therefore, the administration of the drug can be completely controlled.
- the drug-containing layer 26 is covered with the partition wall 30, the drug-containing layer 26 is prevented from being crushed at the time of driving, and the drug-containing layer 26 is surely provided at the targeted skin depth in a more limited range. Can be detained.
- the drug release start time and release time can be controlled, and the drug program can be controlled. Can be achieved. Thereafter, the drug is released from the drug-containing layer 26 as indicated by 28.
- the partition 30 made of a poorly soluble polymer-forming material can control the drug release time from the drug-containing layer 26, so that the drug can be gradually released and the drug can be administered.
- part 20 of the intermediate layer is present on the epidermis side of the drug-containing layer 26 and dissolves later than the drug-containing layer 14 until the insertion part 21 is closed. Prevent leakage. As a result, the administered drug is absorbed into blood vessels throughout the body, enabling efficient treatment.
- FIG. 9 is a diagram showing a method for producing the microneedle 11 for the upper layer of the epidermis and dermis by the ink jet method.
- the tip layer 24 having a recessed boundary is produced by repeatedly discharging the tip layer forming material 23 having a low viscosity and a high surface activity to the concave master 12 for producing microneedles. After the boundary portion where the center is recessed is dried and cured, the drug-containing layer forming material 25 having a high viscosity and containing a drug is discharged to form the drug-containing layer 26 in which the boundary portion protrudes.
- the poorly soluble polymer forming material 29 having a high surface activity and a slow dissolution rate in the body is discharged to produce the partition wall 30 made of the hardly soluble polymer forming material.
- the intermediate layer forming material 25 having a low surface tension and an interfacial activity is discharged to form the intermediate layer 16 in which the boundary portion is recessed.
- the base layer forming material is discharged and integrated with the substrate to manufacture the base layer 18. In this case, the operation for producing the partition wall 30 may be omitted depending on the type of drug contained and the purpose of administration.
- FIG. 9 is a diagram showing treatment with the microneedle 11.
- the microneedle patch provided with the microneedles 11 is driven into the skin using an impact applicator or the like, fracture surfaces 19a and 19b are formed in the intermediate layer 16, and when the microneedle patch is removed, the tip 24, the drug-containing layer 26, A partition wall 30 made of a soluble polymer forming material and a part 20 of the intermediate layer are placed in the dermal papilla layer. Thereafter, the drug is released from the drug-containing layer 26.
- the solubility of the drug-containing layer 26 and the solubility of the partition wall 30 made of a poorly soluble polymer-forming material both the drug release start time and the release time from the drug-containing layer 26 are controlled.
- the administration of the drug can be completely controlled.
- the drug-containing layer 26 is covered with the partition wall 30, the drug-containing layer 26 is prevented from being crushed at the time of administration, and the drug-containing layer 26 is surely disposed at the targeted skin depth in a more limited range.
- the dissolution time of the drug-containing layer 26 and the dissolution time of the partition wall 30 made of a poorly soluble polymer forming material can be controlled independently to control the release start time and release time of the drug. And can achieve a programmed sustained release of the drug.
- a part 20 of the intermediate layer exists on the epidermis side of the drug-containing layer 26 and dissolves later than the drug-containing layer 26. Prevent leakage.
- FIG. 10 is a diagram showing a method for forming the base layer and the substrate.
- the base layer and the substrate may be manufactured separately or integrally.
- A when the base layer and the substrate are separately manufactured, the manufacture is easy, but the microneedle is peeled off at the bonding portion between the base layer and the substrate, and the microneedle is likely to collapse. .
- D by manufacturing the base layer and the substrate integrally as shown in D, such a drawback can be overcome.
- the shape of the boundary between the intermediate layer and the base layer is a flat surface as shown by B, a concave surface as shown by C, or a protruding surface as shown by A and D. May be.
- FIG. 11 is a diagram showing a mode in which the drug-containing layer and the basal layer are in direct contact with each other at the center of the intermediate layer.
- a ′ represents an aspect in which the base layer and the substrate are separately manufactured, and D ′ represents an aspect in which the base layer and the substrate are integrally manufactured.
- the intermediate layer has an annular shape as shown in the right perspective view of FIG.
- a flat boundary part, a boundary part in which the drug-containing layer protrudes toward the basal layer side, and a boundary part in which the drug-containing layer is recessed It was investigated.
- a mixed material of dextran and chondroitin sulfate is mixed as the microneedle forming material, and a mixture of basic fibroblast growth factor (bFGF) and sucrose is mixed into the mixed material of dextran and chondroitin sulfate for the drug-containing layer.
- bFGF basic fibroblast growth factor
- a drug-containing layer forming material (mixed with dextran and chondroitin sulfate in a ratio of 2: 2) prepared so as to have a moderate viscosity and no surface activity is discharged into the concave mold 12 for producing microneedles and bounded.
- a drug-containing layer having a flat part was prepared, dried, and then a base layer forming material was layered on the drug-containing layer, thereby producing a microneedle A having a drug-containing layer having a flat boundary part.
- a drug-containing layer forming material (mixed with dextran and chondroitin sulfate 3: 1) prepared so as to increase the viscosity using an ink jet is discharged into the concave mold 12 for producing microneedles and contains a drug with a protruding boundary. After the layers were prepared and dried, the base layer forming material was layered on the drug-containing layer, thereby producing a microneedle B having a drug-containing layer with a protruding boundary.
- Concave type for microneedle preparation using drug-containing layer forming material (mixed with dextran and chondroitin sulfate in addition to polyethylene glycol 600 at a ratio of 2: 1: 1) prepared using an inkjet to have low viscosity and high surface activity
- a drug-containing layer in which the boundary part is recessed by discharging into the prototype 12 is prepared, and after drying, the base-layer forming material is overlaid on the drug-containing layer, thereby providing a drug-containing layer in which the boundary part is recessed.
- Microneedle C was produced. In this example, the drug content was set to 1.2 ⁇ g per patch.
- A has a flat fracture surface
- B has a concave central portion of the fracture surface
- C has a central portion of the fracture surface protruding. From this example, it was shown that the shape of the boundary portion can be controlled by controlling the water repellency, the viscosity of the forming material, and the surface activity of the concave master 12 for producing microneedles.
- Example 2 the microneedle (A) having no intermediate layer and the drug-containing layer and the base layer are in direct contact with each other at the center of the intermediate layer as shown in FIG. 11, so that the intermediate layer has a ring shape.
- the situation of the fracture surface after use of the formed microneedle (B) was compared.
- the microneedle (A) having no intermediate layer was prepared by using an ink jet and having a moderate viscosity and no surface activity.
- the drug-containing layer forming material (dextran and chondroitin sulfate 2 : Mixed in 2) into the concave mold 12 for producing microneedles to produce a drug-containing layer with a flat boundary, and after drying, the base layer-forming material was overlaid on the drug-containing layer.
- the viscosity containing the drug is high and the surface activity is high.
- a droplet made of a drug-containing layer forming material (mixed dextran and chondroitin sulfate at a ratio of 3: 1) was sprayed into the concave mold 12 for producing microneedles to produce a drug-containing layer with a protruding central part.
- a small amount of low-viscosity and low-surface-activity intermediate layer-forming material (mixed with dextran and chondroitin sulfate in addition to polyethylene glycol 600 in a ratio of 2: 1: 1) was sprayed to prepare an annular intermediate layer. .
- a base layer forming material having a high viscosity was layered to produce a microneedle having a three-layer structure having an annular intermediate layer. All of these microneedles were prepared by an inkjet method using a mixed material of dextran and chondroitin sulfate.
- the drug content was set to 1.8 ⁇ g per patch.
- FIG. 14 shows an enlarged photograph of a microneedle patch having a microneedle (A) having no intermediate layer and a microneedle patch having a microneedle (B) having a ring-shaped intermediate layer after driving.
- A the breakage sites of the adjacent microneedles were various and uniformity was not recognized, while in B, extremely high uniformity in the position and shape of the fracture surface was recognized, and a ring was formed at the edge of the fracture surface. It was observed that the intermediate layer 32 having a shape remained.
- the drug-containing layer can be appropriately placed in the epidermis and the dermis with specific targeting.
- the shape and coating of the drug-containing layer enables precise control of the drug-containing position and the drug release in the drug-containing layer. Since the application range of the treatment by the needle patch can be expanded, the industrial utility in the medical field is high.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Description
(1)先端側から、薬剤含有層、中間層及び基底層を順次備えるマイクロニードルであって、
薬剤含有層と中間層との境界部が、中間層側に膨らんだ形状であることを特徴とする、前記マイクロニードル。
(2)中間層の中央部の厚さが、周縁部より薄いことを特徴とする、上記(1)に記載のマイクロニードル。
(3)薬剤含有層と中間層との境界部が、中間層側に膨らんだドーム形状であることを特徴とする、上記(1)又は(2)に記載のマイクロニードル。
(4)中間層が、凹レンズ形状であることを特徴とする、上記(1)~(3)のいずれかに記載のマイクロニードル。
(5)中間層が、環形状であることを特徴とする、上記(1)~(3)のいずれかに記載のマイクロニードル。
(6)中間層の引張強度が、薬剤含有層の引張強度及び基底層の引張強度より低いことを特徴とする、上記(1)~(5)のいずれかに記載のマイクロニードル。
(7)中間層の引張強度が、薬剤含有層の引張強度及び基底層の引張強度の0.9倍以下であることを特徴とする、上記(6)に記載のマイクロニードル。
(8)中間層と基底層との境界部が、平坦か、中間層側に膨らんだ形状であることを特徴とする、上記(1)~(7)のいずれかに記載のマイクロニードル。
(9)中間層と基底層との境界部が、基底層側に膨らんだ形状であることを特徴とする、上記(1)~(7)のいずれかに記載のマイクロニードル。
(10)薬剤含有層、中間層、基底層の各境界部の形状が、マイクロニードルの形成材料の粘度、界面活性度及び/又は凹型原版表面の撥水性によって制御されることを特徴とする、上記(1)~(9)のいずれかに記載のマイクロニードル。
(11)薬剤含有層の先端側に、薬剤を含有しない先端層をさらに備えることを特徴とする、上記(1)~(10)のいずれかに記載のマイクロニードル。
(12)先端層と薬剤含有層との境界部が、平坦か、先端層側に膨らんだ形状であることを特徴とする、上記(11)に記載のマイクロニードル。
(13)先端層と薬剤含有層との境界部の形状が、マイクロニードルの形成材料の粘度、界面活性度及び/又は凹型原版表面の撥水性によって制御されることを特徴とする、上記(11)又は(12)に記載のマイクロニードル。
(14)中間層が、体内において薬剤含有層が溶解した後に溶解することを特徴とする、上記(1)~(13)のいずれかに記載のマイクロニードル。
(15)薬剤含有層が、薬剤含有層より体内での溶解度の低い難溶性の高分子形成材料で被覆されていることを特徴とする、上記(1)~(14)のいずれかに記載のマイクロニードル。
(16)2又は3以上の薬剤含有層を備えることを特徴とする、上記(1)~(15)のいずれかに記載のマイクロニードル。
(17)隣接する薬剤含有層が、薬剤を含有しない境界層によって隔てられていることを特徴とする、上記(16)に記載のマイクロニードル。
(18)外表面がコーティング材料で被覆されていることを特徴とする、上記(1)~(17)のいずれかに記載のマイクロニードル。
(19)薬剤含有層の周囲に、難溶性の高分子形成材料からなる隔壁をさらに備え、
前記隔壁が、マイクロニードルの打ち込みの際に前記薬剤含有層が破砕されるのを防止し、前記薬剤含有層を標的とする部位に確実に集中して留置させるとともに、所定の時間遅延させて薬剤を放出させることを特徴とする、上記(1)~(18)のいずれかに記載のマイクロニードル。
(20)薬剤含有層の溶解時間、難溶性の高分子形成材料からなる隔壁の溶解時間を制御することで、薬剤の放出開始時間と放出時間を制御し、当該薬剤のプログラムされた徐放化を実現することを特徴とする、上記(1)~(19)のいずれかに記載のマイクロニードル。
(21)薬剤の標的化投与に用いることを特徴とする、上記(1)~(20)のいずれかに記載のマイクロニードル。
(22)上記(1)~(21)のいずれかに記載のマイクロニードルが基板上に複数備えられたことを特徴とするマイクロニードルパッチ。
2 平坦な境界部
3 突出した境界部
4 陥凹した境界部
5,6,7 真皮乳頭下層用のマイクロニードルの、打ち込み後の状態
8,9,10 真皮乳頭層用のマイクロニードルの、打ち込み後の状態
11 表皮、真皮上層用のマイクロニードルの、打ち込み後の状態
12 マイクロニードル作製用凹型原版
13 薬剤含有層形成材料の液滴
14 薬剤含有層
15 中間層形成材料の液滴
16 中間層
17 基底層形成材料の液滴
18 基板と一体化して作製された基底層
19 破断面
20 破断後の、中間層の一部
21 刺入孔
22 溶解して薬剤を放出している薬剤含有層
23 先端層形成材料の液滴
24 先端層
25 薬剤含有層形成材料の液滴
26 薬剤含有層
27 溶解している先端層
28 溶解して薬剤を放出している薬剤含有層
29 難溶性の高分子形成材料の液滴
30 難溶性の高分子形成材料からなる隔壁
31 難溶性の高分子形成材料からなる隔壁(溶解途中)
32 投与後に破断面辺縁に遺残した環状形の中間層
101 角層
102 表皮
103 真皮乳頭層
104 真皮乳頭下層
105 真皮網状層
106 真皮乳頭層の毛細血管網
Claims (22)
- 先端側から、薬剤含有層、中間層及び基底層を順次備えるマイクロニードルであって、
薬剤含有層と中間層との境界部が、中間層側に膨らんだ形状であることを特徴とする、前記マイクロニードル。 - 中間層の中央部の厚さが、周縁部より薄いことを特徴とする、請求項1に記載のマイクロニードル。
- 薬剤含有層と中間層との境界部が、中間層側に膨らんだドーム形状であることを特徴とする、請求項1又は2に記載のマイクロニードル。
- 中間層が、凹レンズ形状であることを特徴とする、請求項1~3のいずれかに記載のマイクロニードル。
- 中間層が、環形状であることを特徴とする、請求項1~3のいずれかに記載のマイクロニードル。
- 中間層の引張強度が、薬剤含有層の引張強度及び基底層の引張強度より低いことを特徴とする、請求項1~5のいずれかに記載のマイクロニードル。
- 中間層の引張強度が、薬剤含有層の引張強度及び基底層の引張強度の0.9倍以下であることを特徴とする、請求項6に記載のマイクロニードル。
- 中間層と基底層との境界部が、平坦か、中間層側に膨らんだ形状であることを特徴とする、請求項1~7のいずれかに記載のマイクロニードル。
- 中間層と基底層との境界部が、基底層側に膨らんだ形状であることを特徴とする、請求項1~7のいずれかに記載のマイクロニードル。
- 薬剤含有層、中間層、基底層の各境界部の形状が、マイクロニードルの形成材料の粘度、界面活性度及び/又は凹型原版表面の撥水性によって制御されることを特徴とする、請求項1~9のいずれかに記載のマイクロニードル。
- 薬剤含有層の先端側に、薬剤を含有しない先端層をさらに備えることを特徴とする、請求項1~10のいずれかに記載のマイクロニードル。
- 先端層と薬剤含有層との境界部が、平坦か、先端層側に膨らんだ形状であることを特徴とする、請求項11に記載のマイクロニードル。
- 先端層と薬剤含有層との境界部の形状が、マイクロニードルの形成材料の粘度、界面活性度及び/又は凹型原版表面の撥水性によって制御されることを特徴とする、請求項11又は12に記載のマイクロニードル。
- 中間層が、体内において薬剤含有層が溶解した後に溶解することを特徴とする、請求項1~13のいずれかに記載のマイクロニードル。
- 薬剤含有層が、薬剤含有層より体内での溶解度の低い難溶性の高分子形成材料で被覆されていることを特徴とする、請求項1~14のいずれかに記載のマイクロニードル。
- 2又は3以上の薬剤含有層を備えることを特徴とする、請求項1~15のいずれかに記載のマイクロニードル。
- 隣接する薬剤含有層が、薬剤を含有しない境界層によって隔てられていることを特徴とする、請求項16に記載のマイクロニードル。
- 外表面がコーティング材料で被覆されていることを特徴とする、請求項1~17のいずれかに記載のマイクロニードル。
- 薬剤含有層の周囲に、難溶性の高分子形成材料からなる隔壁をさらに備え、
前記隔壁が、マイクロニードルの打ち込みの際に前記薬剤含有層が破砕されるのを防止し、前記薬剤含有層を標的とする部位に確実に集中して留置させるとともに、所定の時間遅延させて薬剤を放出させることを特徴とする、請求項1~18のいずれかに記載のマイクロニードル。 - 薬剤含有層の溶解時間、難溶性の高分子形成材料からなる隔壁の溶解時間を制御することで、薬剤の放出開始時間と放出時間を制御し、当該薬剤のプログラムされた徐放化を実現することを特徴とする、請求項1~19のいずれかに記載のマイクロニードル。
- 薬剤の標的化投与に用いることを特徴とする、請求項1~20のいずれかに記載のマイクロニードル。
- 請求項1~21のいずれかに記載のマイクロニードルが基板上に複数備えられたことを特徴とするマイクロニードルパッチ。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020187016181A KR20180096610A (ko) | 2015-12-18 | 2016-12-16 | 마이크로 니들 및 마이크로 니들 패치 |
EP16875132.9A EP3391935A4 (en) | 2015-12-18 | 2016-12-16 | MICRO NEEDLE AND MICRO NEEDLE STAMP |
US16/062,865 US20190001108A1 (en) | 2015-12-18 | 2016-12-16 | Microneedle and microneedle patch |
JP2017556338A JP6558812B2 (ja) | 2015-12-18 | 2016-12-16 | マイクロニードル及びマイクロニードルパッチ |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015247640 | 2015-12-18 | ||
JP2015-247640 | 2015-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2017104144A1 true WO2017104144A1 (ja) | 2017-06-22 |
Family
ID=59055973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2016/005166 WO2017104144A1 (ja) | 2015-12-18 | 2016-12-16 | マイクロニードル及びマイクロニードルパッチ |
Country Status (5)
Country | Link |
---|---|
US (1) | US20190001108A1 (ja) |
EP (1) | EP3391935A4 (ja) |
JP (1) | JP6558812B2 (ja) |
KR (1) | KR20180096610A (ja) |
WO (1) | WO2017104144A1 (ja) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019075275A1 (en) * | 2017-10-11 | 2019-04-18 | Georgia Tech Research Corporation | SEPARABLE MICROARRAY MATRICES FOR PROLONGED MEDICATION RELEASE |
JP2021511124A (ja) * | 2018-01-18 | 2021-05-06 | シンビア カンパニー リミテッド | 植込み型マイクロニードルおよびその製造方法 |
JP2022504856A (ja) * | 2018-10-08 | 2022-01-13 | インダストリー-アカデミック コーポレーション ファウンデーション,ヨンセイ ユニバーシティ | マイクロ構造体 |
WO2023058760A1 (ja) * | 2021-10-07 | 2023-04-13 | 凸版印刷株式会社 | 収容デバイス |
US11642506B1 (en) | 2021-12-02 | 2023-05-09 | Win Coat Corporation | Multi-layered microneedle patch and method of manufacturing the same |
JP2023527945A (ja) * | 2021-05-04 | 2023-07-03 | フェロカ インコーポレーテッド | マイクロニードルパッチ |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113332589B (zh) * | 2021-05-26 | 2023-05-09 | 四川大学 | 用于口腔黏膜给药的装载双重药物的聚合物微针及其制备方法 |
WO2023283385A1 (en) * | 2021-07-07 | 2023-01-12 | The Regents Of The University Of California | Wearable, non-intrusive microneedle sensor |
US20230302265A1 (en) * | 2021-07-15 | 2023-09-28 | Feroka Inc. | Microneedle patch and method of manufacturing microneedle patch |
KR102644973B1 (ko) * | 2021-07-15 | 2024-03-07 | 주식회사 페로카 | 마이크로니들 패치 제조방법 |
KR102635939B1 (ko) * | 2021-07-15 | 2024-02-14 | 주식회사 페로카 | 마이크로니들 패치 |
KR20230103449A (ko) | 2021-12-31 | 2023-07-07 | 가천대학교 산학협력단 | 탐스로신을 함유하는 마이크로니들 및 이의 제조방법 |
CN114366700B (zh) * | 2022-01-19 | 2023-10-03 | 华工新颜(深圳)科技有限公司 | 一种祛眼袋的梅片龙脑香可溶性微针眼贴及其制备方法 |
CN115092875A (zh) * | 2022-06-17 | 2022-09-23 | 上海烨映微电子科技股份有限公司 | 微针芯片及其制备方法 |
CN117159510A (zh) * | 2023-10-16 | 2023-12-05 | 中科微针(北京)科技有限公司 | 一种含透气基底材料的微针膜及其制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008062832A1 (fr) * | 2006-11-22 | 2008-05-29 | Toppan Printing Co., Ltd. | Matrice à micro-aiguilles et son procédé de production |
WO2008130587A2 (en) * | 2007-04-16 | 2008-10-30 | Corium International, Inc. | Solvent-cast microneedle arrays containing active |
JP2009066104A (ja) * | 2007-09-12 | 2009-04-02 | Toppan Printing Co Ltd | 微細針構造体及び微細針構造体デバイス |
JP2012200572A (ja) | 2011-03-28 | 2012-10-22 | Toray Eng Co Ltd | マイクロニードルシートおよびその製造方法 |
JP2015136422A (ja) | 2014-01-21 | 2015-07-30 | 凸版印刷株式会社 | マイクロニードル、および、マイクロニードルの製造方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002327675A1 (en) * | 2001-09-19 | 2003-04-01 | Biovalve Technologies, Inc. | Microneedles, microneedle arrays, and systems and methods relating to same |
EP1898807A1 (en) * | 2005-03-28 | 2008-03-19 | Alza Corporation | Microprojections with capillary control features and method |
WO2007112309A2 (en) * | 2006-03-24 | 2007-10-04 | 3M Innovative Properties Company | Process for making microneedles, microneedle arrays, masters, and replication tools |
WO2008053481A1 (en) * | 2006-11-01 | 2008-05-08 | Svip 6 Llc | Microneedle arrays |
JP2010233674A (ja) * | 2009-03-30 | 2010-10-21 | Fujifilm Corp | マイクロニードルシート及びその使用方法並びに製造方法 |
EP2338557A1 (en) * | 2009-12-23 | 2011-06-29 | Debiotech S.A. | Soluble microneedle |
DE102010001667A1 (de) * | 2010-02-08 | 2011-08-11 | Robert Bosch GmbH, 70469 | Herstellungsverfahren für eine poröse Mikronadelanordnung mit Rückseitenanschluss und entsprechende poröse Mikronadelanordnung |
JP5587647B2 (ja) * | 2010-03-29 | 2014-09-10 | 東レエンジニアリング株式会社 | マイクロニードルシートの製造方法 |
CN104780968B (zh) * | 2012-11-13 | 2017-07-11 | 富士胶片株式会社 | 经皮吸收片材及其制造方法 |
JP6285277B2 (ja) * | 2014-05-15 | 2018-02-28 | 富士フイルム株式会社 | 経皮吸収シートおよび経皮吸収シートの製造方法 |
WO2016147476A1 (ja) * | 2015-03-18 | 2016-09-22 | 凸版印刷株式会社 | 薬剤投与装置および薬剤投与装置の製造方法 |
JP6541128B2 (ja) * | 2015-12-15 | 2019-07-10 | 株式会社ラボ・ジュヴェルサ | マイクロニードルパッチ、及びその製造方法並びにマイクロニードルアレイ製造装置 |
-
2016
- 2016-12-16 WO PCT/JP2016/005166 patent/WO2017104144A1/ja active Application Filing
- 2016-12-16 EP EP16875132.9A patent/EP3391935A4/en not_active Withdrawn
- 2016-12-16 US US16/062,865 patent/US20190001108A1/en not_active Abandoned
- 2016-12-16 JP JP2017556338A patent/JP6558812B2/ja active Active
- 2016-12-16 KR KR1020187016181A patent/KR20180096610A/ko unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008062832A1 (fr) * | 2006-11-22 | 2008-05-29 | Toppan Printing Co., Ltd. | Matrice à micro-aiguilles et son procédé de production |
WO2008130587A2 (en) * | 2007-04-16 | 2008-10-30 | Corium International, Inc. | Solvent-cast microneedle arrays containing active |
JP2009066104A (ja) * | 2007-09-12 | 2009-04-02 | Toppan Printing Co Ltd | 微細針構造体及び微細針構造体デバイス |
JP2012200572A (ja) | 2011-03-28 | 2012-10-22 | Toray Eng Co Ltd | マイクロニードルシートおよびその製造方法 |
JP2015136422A (ja) | 2014-01-21 | 2015-07-30 | 凸版印刷株式会社 | マイクロニードル、および、マイクロニードルの製造方法 |
Non-Patent Citations (1)
Title |
---|
See also references of EP3391935A4 |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019075275A1 (en) * | 2017-10-11 | 2019-04-18 | Georgia Tech Research Corporation | SEPARABLE MICROARRAY MATRICES FOR PROLONGED MEDICATION RELEASE |
JP2021511124A (ja) * | 2018-01-18 | 2021-05-06 | シンビア カンパニー リミテッド | 植込み型マイクロニードルおよびその製造方法 |
JP7055954B2 (ja) | 2018-01-18 | 2022-04-19 | シンビア カンパニー リミテッド | 植込み型マイクロニードルおよびその製造方法 |
US11938308B2 (en) | 2018-01-18 | 2024-03-26 | Snvia Co., Ltd. | Implantable microneedle and manufacturing method therefor |
JP2022504856A (ja) * | 2018-10-08 | 2022-01-13 | インダストリー-アカデミック コーポレーション ファウンデーション,ヨンセイ ユニバーシティ | マイクロ構造体 |
JP7324448B2 (ja) | 2018-10-08 | 2023-08-10 | インダストリー-アカデミック コーポレーション ファウンデーション,ヨンセイ ユニバーシティ | マイクロ構造体 |
JP2023527945A (ja) * | 2021-05-04 | 2023-07-03 | フェロカ インコーポレーテッド | マイクロニードルパッチ |
WO2023058760A1 (ja) * | 2021-10-07 | 2023-04-13 | 凸版印刷株式会社 | 収容デバイス |
US11642506B1 (en) | 2021-12-02 | 2023-05-09 | Win Coat Corporation | Multi-layered microneedle patch and method of manufacturing the same |
JP2023082642A (ja) * | 2021-12-02 | 2023-06-14 | 怡定興科技股▲分▼有限公司 | 多層マイクロニードルパッチ及びその製造方法 |
Also Published As
Publication number | Publication date |
---|---|
JPWO2017104144A1 (ja) | 2018-07-12 |
JP6558812B2 (ja) | 2019-08-14 |
EP3391935A4 (en) | 2019-08-14 |
US20190001108A1 (en) | 2019-01-03 |
KR20180096610A (ko) | 2018-08-29 |
EP3391935A1 (en) | 2018-10-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6558812B2 (ja) | マイクロニードル及びマイクロニードルパッチ | |
AU2020256382C1 (en) | Microarray for delivery of therapeutic agent and methods of use | |
US11052231B2 (en) | Microarray for delivery of therapeutic agent and methods of use | |
JP6169149B2 (ja) | マイクロニードル及びマイクロニードルパッチ | |
Elahpour et al. | 3D printed microneedles for transdermal drug delivery: A brief review of two decades | |
JP6481613B2 (ja) | マイクロニードル、および、マイクロニードルの製造方法 | |
KR101746024B1 (ko) | 다공성 코팅층이 코팅된 마이크로니들과 이것의 제조 방법 그리고 마이크로니들이 구비된 마이크로니들패치 | |
JP6681626B2 (ja) | マイクロニードル及びその製造方法 | |
EP2946805A1 (en) | Microneedle, mould for producing same, and production method for same | |
JP2016511014A5 (ja) | ||
JP2006512164A (ja) | 複合部材を有する有効成分送達装置 | |
US20120193840A1 (en) | Method of manufacturing solid solution perforator patches | |
US11160964B2 (en) | Microneedle patch and fabrication device for production of multilayered microneedles | |
JP2015016160A (ja) | マイクロニードル |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 16875132 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 2017556338 Country of ref document: JP Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 20187016181 Country of ref document: KR Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2016875132 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2016875132 Country of ref document: EP Effective date: 20180718 |