WO2016156869A2 - Composition antimicrobienne - Google Patents
Composition antimicrobienne Download PDFInfo
- Publication number
- WO2016156869A2 WO2016156869A2 PCT/GB2016/050932 GB2016050932W WO2016156869A2 WO 2016156869 A2 WO2016156869 A2 WO 2016156869A2 GB 2016050932 W GB2016050932 W GB 2016050932W WO 2016156869 A2 WO2016156869 A2 WO 2016156869A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition according
- microbial
- composition
- component
- amino acid
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 280
- 239000004599 antimicrobial Substances 0.000 title claims abstract description 110
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 96
- 150000001413 amino acids Chemical class 0.000 claims abstract description 82
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 58
- 150000003839 salts Chemical class 0.000 claims abstract description 55
- 229960003260 chlorhexidine Drugs 0.000 claims abstract description 49
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims abstract description 28
- 239000002798 polar solvent Substances 0.000 claims abstract description 14
- 235000001014 amino acid Nutrition 0.000 claims description 80
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 40
- 150000001875 compounds Chemical class 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims description 26
- -1 halide anion Chemical class 0.000 claims description 26
- 244000005700 microbiome Species 0.000 claims description 26
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 19
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 16
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 16
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 15
- 229960001950 benzethonium chloride Drugs 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 12
- 230000015572 biosynthetic process Effects 0.000 claims description 12
- 239000004475 Arginine Substances 0.000 claims description 11
- 239000008139 complexing agent Substances 0.000 claims description 11
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 claims description 10
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 9
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 8
- 239000004094 surface-active agent Substances 0.000 claims description 8
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 7
- 150000001412 amines Chemical class 0.000 claims description 6
- 238000002169 hydrotherapy Methods 0.000 claims description 6
- 230000000813 microbial effect Effects 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000000758 substrate Substances 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 5
- OCBHHZMJRVXXQK-UHFFFAOYSA-M benzyl-dimethyl-tetradecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 OCBHHZMJRVXXQK-UHFFFAOYSA-M 0.000 claims description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 5
- XTJKNGLLPGBHHO-HNNXBMFYSA-N (2s)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoic acid Chemical compound CCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCCN=C(N)N XTJKNGLLPGBHHO-HNNXBMFYSA-N 0.000 claims description 4
- CVHZOJJKTDOEJC-UHFFFAOYSA-M 1,1-dioxo-1,2-benzothiazol-3-olate Chemical compound C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-M 0.000 claims description 4
- OAYXUHPQHDHDDZ-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethanol Chemical compound CCCCOCCOCCO OAYXUHPQHDHDDZ-UHFFFAOYSA-N 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 4
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 claims description 4
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 4
- 229910052709 silver Inorganic materials 0.000 claims description 4
- 239000004332 silver Substances 0.000 claims description 4
- CGLRMJMKUHEFQB-UHFFFAOYSA-N 1-bromo-1-nitropropane Chemical class CCC(Br)[N+]([O-])=O CGLRMJMKUHEFQB-UHFFFAOYSA-N 0.000 claims description 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 3
- 229960001716 benzalkonium Drugs 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 150000002989 phenols Chemical class 0.000 claims description 3
- VKZRWSNIWNFCIQ-WDSKDSINSA-N (2s)-2-[2-[[(1s)-1,2-dicarboxyethyl]amino]ethylamino]butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC(O)=O VKZRWSNIWNFCIQ-WDSKDSINSA-N 0.000 claims description 2
- VKZRWSNIWNFCIQ-UHFFFAOYSA-N 2-[2-(1,2-dicarboxyethylamino)ethylamino]butanedioic acid Chemical compound OC(=O)CC(C(O)=O)NCCNC(C(O)=O)CC(O)=O VKZRWSNIWNFCIQ-UHFFFAOYSA-N 0.000 claims description 2
- JMHWNJGXUIJPKG-UHFFFAOYSA-N CC(=O)O[SiH](CC=C)OC(C)=O Chemical compound CC(=O)O[SiH](CC=C)OC(C)=O JMHWNJGXUIJPKG-UHFFFAOYSA-N 0.000 claims description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- WDJHALXBUFZDSR-UHFFFAOYSA-N acetoacetic acid Chemical compound CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 claims description 2
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 claims description 2
- SCXCDVTWABNWLW-UHFFFAOYSA-M decyl-dimethyl-octylazanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCC SCXCDVTWABNWLW-UHFFFAOYSA-M 0.000 claims description 2
- 229940050410 gluconate Drugs 0.000 claims description 2
- 235000013922 glutamic acid Nutrition 0.000 claims description 2
- 239000004220 glutamic acid Substances 0.000 claims description 2
- 150000002391 heterocyclic compounds Chemical class 0.000 claims description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 229960001774 octenidine Drugs 0.000 claims description 2
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 claims description 2
- URDCARMUOSMFFI-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid Chemical compound OCCN(CC(O)=O)CCN(CC(O)=O)CC(O)=O URDCARMUOSMFFI-UHFFFAOYSA-N 0.000 claims 2
- CIEZZGWIJBXOTE-UHFFFAOYSA-N 2-[bis(carboxymethyl)amino]propanoic acid Chemical compound OC(=O)C(C)N(CC(O)=O)CC(O)=O CIEZZGWIJBXOTE-UHFFFAOYSA-N 0.000 claims 2
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 2
- 229960003330 pentetic acid Drugs 0.000 claims 2
- WGYZMNBUZFHYRX-UHFFFAOYSA-N 1-(1-methoxypropan-2-yloxy)propan-2-ol Chemical compound COCC(C)OCC(C)O WGYZMNBUZFHYRX-UHFFFAOYSA-N 0.000 claims 1
- CUDYYMUUJHLCGZ-UHFFFAOYSA-N 2-(2-methoxypropoxy)propan-1-ol Chemical compound COC(C)COC(C)CO CUDYYMUUJHLCGZ-UHFFFAOYSA-N 0.000 claims 1
- XNCSCQSQSGDGES-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]propyl-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)C(C)CN(CC(O)=O)CC(O)=O XNCSCQSQSGDGES-UHFFFAOYSA-N 0.000 claims 1
- DMQQXDPCRUGSQB-UHFFFAOYSA-N 2-[3-[bis(carboxymethyl)amino]propyl-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CCCN(CC(O)=O)CC(O)=O DMQQXDPCRUGSQB-UHFFFAOYSA-N 0.000 claims 1
- 150000003973 alkyl amines Chemical class 0.000 claims 1
- 238000009472 formulation Methods 0.000 abstract description 28
- 229940024606 amino acid Drugs 0.000 description 65
- 239000000306 component Substances 0.000 description 54
- 239000000047 product Substances 0.000 description 31
- 239000000463 material Substances 0.000 description 22
- 239000004615 ingredient Substances 0.000 description 12
- 238000012360 testing method Methods 0.000 description 11
- 235000009697 arginine Nutrition 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 8
- 229960004592 isopropanol Drugs 0.000 description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 8
- 239000007921 spray Substances 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 150000001298 alcohols Chemical class 0.000 description 7
- 125000000129 anionic group Chemical group 0.000 description 7
- 125000000962 organic group Chemical group 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 150000003862 amino acid derivatives Chemical class 0.000 description 6
- 230000003115 biocidal effect Effects 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 125000002091 cationic group Chemical group 0.000 description 6
- 125000000524 functional group Chemical group 0.000 description 6
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical class Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 229920000297 Rayon Polymers 0.000 description 5
- 230000000840 anti-viral effect Effects 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical class CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 240000002989 Euphorbia neriifolia Species 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical class OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 125000003277 amino group Chemical group 0.000 description 4
- 239000002280 amphoteric surfactant Substances 0.000 description 4
- 150000001450 anions Chemical class 0.000 description 4
- 230000000843 anti-fungal effect Effects 0.000 description 4
- 230000001046 anti-mould Effects 0.000 description 4
- 239000002546 antimould Substances 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 239000003139 biocide Substances 0.000 description 4
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 125000002843 carboxylic acid group Chemical group 0.000 description 4
- 235000014655 lactic acid Nutrition 0.000 description 4
- 239000004310 lactic acid Substances 0.000 description 4
- 229940085991 phosphate ion Drugs 0.000 description 4
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- QPRQEDXDYOZYLA-UHFFFAOYSA-N 2-methylbutan-1-ol Chemical compound CCC(C)CO QPRQEDXDYOZYLA-UHFFFAOYSA-N 0.000 description 3
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 description 3
- 241000195940 Bryophyta Species 0.000 description 3
- 241001646716 Escherichia coli K-12 Species 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 125000003342 alkenyl group Chemical group 0.000 description 3
- 150000001408 amides Chemical group 0.000 description 3
- 230000001098 anti-algal effect Effects 0.000 description 3
- 230000000656 anti-yeast Effects 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 238000004851 dishwashing Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 235000011929 mousse Nutrition 0.000 description 3
- 230000002085 persistent effect Effects 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000011012 sanitization Methods 0.000 description 3
- 239000002453 shampoo Substances 0.000 description 3
- 239000000344 soap Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- 229940123208 Biguanide Drugs 0.000 description 2
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical class [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000991587 Enterovirus C Species 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 description 2
- 241001263478 Norovirus Species 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 229920001131 Pulp (paper) Polymers 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- 208000000260 Warts Diseases 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 229940009098 aspartate Drugs 0.000 description 2
- 229960003168 bronopol Drugs 0.000 description 2
- 239000006172 buffering agent Substances 0.000 description 2
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-O carboxymethyl-[3-(dodecanoylamino)propyl]-dimethylazanium Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)=O MRUAUOIMASANKQ-UHFFFAOYSA-O 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 230000001627 detrimental effect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 125000001033 ether group Chemical group 0.000 description 2
- 239000002979 fabric softener Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 235000012907 honey Nutrition 0.000 description 2
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 229940049920 malate Drugs 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000003641 microbiacidal effect Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 235000010292 orthophenyl phenol Nutrition 0.000 description 2
- 239000004306 orthophenyl phenol Substances 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000003352 sequestering agent Substances 0.000 description 2
- 201000010153 skin papilloma Diseases 0.000 description 2
- JDVPQXZIJDEHAN-UHFFFAOYSA-M succinamate Chemical compound NC(=O)CCC([O-])=O JDVPQXZIJDEHAN-UHFFFAOYSA-M 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 2
- 229940095064 tartrate Drugs 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 239000006150 trypticase soy agar Substances 0.000 description 2
- 239000012137 tryptone Substances 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- QLAJNZSPVITUCQ-UHFFFAOYSA-N 1,3,2-dioxathietane 2,2-dioxide Chemical compound O=S1(=O)OCO1 QLAJNZSPVITUCQ-UHFFFAOYSA-N 0.000 description 1
- ZXSQEZNORDWBGZ-UHFFFAOYSA-N 1,3-dihydropyrrolo[2,3-b]pyridin-2-one Chemical compound C1=CN=C2NC(=O)CC2=C1 ZXSQEZNORDWBGZ-UHFFFAOYSA-N 0.000 description 1
- CZKPBCHPLNOUSJ-UHFFFAOYSA-N 1-octadecoxyperoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOOOCCCCCCCCCCCCCCCCCC CZKPBCHPLNOUSJ-UHFFFAOYSA-N 0.000 description 1
- HJCCGMPSYDZKFT-UHFFFAOYSA-N 2,2-diiodobutanoic acid Chemical compound CCC(I)(I)C(O)=O HJCCGMPSYDZKFT-UHFFFAOYSA-N 0.000 description 1
- ZILVNHNSYBNLSZ-UHFFFAOYSA-N 2-(diaminomethylideneamino)guanidine Chemical compound NC(N)=NNC(N)=N ZILVNHNSYBNLSZ-UHFFFAOYSA-N 0.000 description 1
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 241000203069 Archaea Species 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- XYRSBXSCKUNWOV-UHFFFAOYSA-N C[N](C)(C)Cc1ccccc1 Chemical compound C[N](C)(C)Cc1ccccc1 XYRSBXSCKUNWOV-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical class [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical class CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical class OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 206010012444 Dermatitis diaper Diseases 0.000 description 1
- 108010016626 Dipeptides Proteins 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920000289 Polyquaternium Chemical class 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 206010061494 Rhinovirus infection Diseases 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010041925 Staphylococcal infections Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 241000934136 Verruca Species 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 150000001279 adipic acids Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 229920001448 anionic polyelectrolyte Polymers 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 229910052785 arsenic Chemical class 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical class [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 238000004500 asepsis Methods 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229960002788 cetrimonium chloride Drugs 0.000 description 1
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- WDRFFJWBUDTUCA-UHFFFAOYSA-N chlorhexidine acetate Chemical compound CC(O)=O.CC(O)=O.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WDRFFJWBUDTUCA-UHFFFAOYSA-N 0.000 description 1
- 229960001884 chlorhexidine diacetate Drugs 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000004567 concrete Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 229960002433 cysteine Drugs 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Chemical class CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- DGTVXEHQMSJRPE-UHFFFAOYSA-M difluorophosphinate Chemical compound [O-]P(F)(F)=O DGTVXEHQMSJRPE-UHFFFAOYSA-M 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 229950005627 embonate Drugs 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000009920 food preservation Methods 0.000 description 1
- 150000004675 formic acid derivatives Chemical class 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Chemical class CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 229940049906 glutamate Drugs 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 229960002743 glutamine Drugs 0.000 description 1
- 150000002311 glutaric acids Chemical class 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 239000000383 hazardous chemical Substances 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 235000014304 histidine Nutrition 0.000 description 1
- 229960002885 histidine Drugs 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 235000014705 isoleucine Nutrition 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- PHTQWCKDNZKARW-UHFFFAOYSA-N isopentyl alcohol Natural products CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 150000003893 lactate salts Chemical class 0.000 description 1
- 229960003136 leucine Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 1
- 235000006109 methionine Nutrition 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 229960004452 methionine Drugs 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 229940086539 peg-7 glyceryl cocoate Drugs 0.000 description 1
- 235000008729 phenylalanine Nutrition 0.000 description 1
- 229960005190 phenylalanine Drugs 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229920002553 poly(2-methacrylolyloxyethyltrimethylammonium chloride) polymer Polymers 0.000 description 1
- 229920000172 poly(styrenesulfonic acid) Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229940005642 polystyrene sulfonic acid Drugs 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000000135 prohibitive effect Effects 0.000 description 1
- 229960002429 proline Drugs 0.000 description 1
- 235000013930 proline Nutrition 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940043131 pyroglutamate Drugs 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229960001153 serine Drugs 0.000 description 1
- 235000004400 serine Nutrition 0.000 description 1
- 229910001958 silver carbonate Inorganic materials 0.000 description 1
- LKZMBDSASOBTPN-UHFFFAOYSA-L silver carbonate Substances [Ag].[O-]C([O-])=O LKZMBDSASOBTPN-UHFFFAOYSA-L 0.000 description 1
- 229940071575 silver citrate Drugs 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- QZRSVBDWRWTHMT-UHFFFAOYSA-M silver;3-carboxy-3,5-dihydroxy-5-oxopentanoate Chemical compound [Ag+].OC(=O)CC(O)(C([O-])=O)CC(O)=O QZRSVBDWRWTHMT-UHFFFAOYSA-M 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000013042 solid detergent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- JDVPQXZIJDEHAN-UHFFFAOYSA-N succinamic acid Chemical class NC(=O)CCC(O)=O JDVPQXZIJDEHAN-UHFFFAOYSA-N 0.000 description 1
- 235000011044 succinic acid Nutrition 0.000 description 1
- 150000003444 succinic acids Chemical class 0.000 description 1
- 239000003784 tall oil Substances 0.000 description 1
- UZVUJVFQFNHRSY-OUTKXMMCSA-J tetrasodium;(2s)-2-[bis(carboxylatomethyl)amino]pentanedioate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CC[C@@H](C([O-])=O)N(CC([O-])=O)CC([O-])=O UZVUJVFQFNHRSY-OUTKXMMCSA-J 0.000 description 1
- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 1
- 235000008521 threonine Nutrition 0.000 description 1
- 229960002898 threonine Drugs 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- QUTYHQJYVDNJJA-UHFFFAOYSA-K trisilver;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Ag+].[Ag+].[Ag+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QUTYHQJYVDNJJA-UHFFFAOYSA-K 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- 235000002374 tyrosine Nutrition 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/32—Ingredients for reducing the noxious effect of the active substances to organisms other than pests, e.g. toxicity reducing compositions, self-destructing compositions
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N39/00—Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or, e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Definitions
- This invention relates to anti-microbial compositions and to formulations including the antimicrobial compositions.
- the invention relates to anti-microbial compositions that can be used on skin.
- Micro-organisms such as bacteria and viruses, for example norovirus, polio virus and adenovirus, are well known to present health hazards due to infection or contamination. Along with fungi, yeasts and other micro-organisms they can also cause spoilage of items such as food, clothing and produce unpleasant odours. When micro-organisms are present on the surface of a substrate, such as skin, they can replicate rapidly to form colonies.
- anti-microbial agents can destroy micro-organisms that are present in a wide range of environments.
- anti-microbial agents that may be used in medical, industrial, commercial, domestic and marine environments are known.
- Many of the known anti-microbial agents have previously been included in compositions for use in these environments for various applications.
- Known anti-microbial agents and the compositions that contain these anti-microbial agents act via a number of different mechanisms.
- anti-microbial agents are poisonous to microorganisms and, therefore, destroy microorganisms with which they are contacted.
- anti-microbial agent examples include hypochlorites (bleaches), phenol and compounds thereof, and salts of copper, tin and arsenic.
- hypochlorite bleach is very effective at killing micro-organisms on solid surfaces, but inappropriate for application to skin due to its corrosive properties.
- these materials tend to be effective in a wet environment for sterilization and cleansing but stop working shortly after drying.
- Many skin sanitizers are alcohol-based. These are typically an alcohol-containing preparation designed for application to the hands for reducing the number of viable microorganisms on the hands. Such preparations typically contain 60%-95% ethanol or isopropanol.
- isopropyl alcohol has established antibacterial properties, it has the disadvantage that, when used regularly, it can cause dryness and skin irritation. As a result some people may be reluctant to use such creams, soaps and other compositions comprising significant levels of isopropanol.
- compositions comprising this type of anti-microbial agent can, therefore, be problematic. There can also be problems associated with the use of compositions containing this type of anti-microbial agent, particularly in consumer materials where it is difficult to ensure that they are used for designated purposes.
- toxicity is intended to refer to toxicity to complex organisms such as mammals. References to "toxic” are to be construed accordingly.
- anti-microbial agents not just for topical application on skin but for general use. For example, some anti-microbial agents once they enter the environment can harm other organisms. They can also be very stable and persist in the environment for long periods causing concerns around build-up and residual levels. Because of these factors the list of effective and available anti-microbial agents, particularly for use on skin, is becoming more restricted and the burden of registering new anti-microbials more prohibitive. At the same time the public are becoming increasingly concerned with sanitization, both of person and property following outbreaks such as MRSA in hospitals.
- compositions for a variety of applications and uses such as compositions for use on skin, for example hand sanitising agents, that have anti-microbial properties and that address one or more of the problems set out above.
- compositions for use on skin for example hand sanitising agents
- the potential reactivity of an anti-microbial agent once in a composition is important as some anti-microbial agents are rendered inactive by chemical reaction.
- compositions containing these combinations of components can have some surprising and unexpected properties.
- the listing or discussion of an apparently prior-published document in this specification should not necessarily be taken as an acknowledgment that the document is part of the state of the art or is common general knowledge.
- the present invention provides an antimicrobial composition comprising:
- an anti-microbial component comprising two or more anti-microbial quaternary ammonium compounds or at least one anti-microbial quaternary ammonium compound and chlorhexidine, or a chlorhexidine salt;
- Amino acids are well known organic compounds that are essential for life. They are characterised by having an amine (Nhb) functional group attached to the carbon adjacent to a carboxylic acid (CO2H) functional group, along with a side-chain that is specific to the amino acid.
- An amino acid has the general formula shown below.
- amino acids have both an amine and carboxylic acid group they can act as both a base and an acid. At low pH the predominant form will have a neutral carboxylic acid group and a positive Ammonium ion (net charge +1 ). At high pH it will have a negative carboxylate and neutral amino group (net charge -1 ). At an intermediate pH, the amino acid will usually contain both a negative carboxylate and a positive ammonium group, so has net zero charge.
- Arginine is one of the most common amino acids and is shown below.
- amino acids are glycine, lysine, giutamate, glutamine, aspartate, asparagine, histidine, proline, methionine, cysteine, serine, threonine, isoleucine, phenylalanine, tyrosine, tryptophan, valine and leucine.
- amino acid we also include chains of amino acids such as peptides and polypeptides. Peptides are formed when individual amino acids are linked together via peptide (amide) bonds formed by the reaction of the amine group of one amino acid with the carboxyl group of another.
- the shortest peptides are dipeptides consisting of two amino acids joined by a single peptide bond, followed by tripeptides, tetrapeptides and so on.
- a polypeptide is a long, continuous, and unbranched peptide chain.
- derivative of an amino acid we mean an amino acid in which the alpha-amino and/or carboxyl functional groups are substituted by an alternative organic group, or an amino acid in which the functional groups in the side chain of an amino acid are substituted by an alternative organic group, or an amino acid in which the alpha-amino and/or carboxyl functional groups are substituted by an alternative organic group and/or the functional groups in its side chain are also substituted by an alternative organic group.
- Alternative organic groups include, but are not limited to, alkenyl, phenyl, amide, ester, alcohol, and ether groups or combinations thereof.
- An example of a derivative of an amino acid is N- lauroyl-L-arginine ethyl ester whose structure is shown below.
- salt of an amino acid we mean the cationic or anionic form of the amino acid combined with a counter-ion, which is an ion of opposite charge.
- the cationic form of the amino acid is formed by the transfer of a positively charged hydrogen ion from an acid to an amino group in the amino acid.
- the counter-ion is derived from the acid from which the hydrogen ion is transferred from.
- the anionic form of the amino acid is formed by the loss of a positively charged hydrogen ion from the carboxylic acid group in the amino acid. In this case the counter-ion is derived from the base to which the hydrogen ion is transferred to.
- An example of an amino acid salt is arginine lactate which is commercially available in AH Care L65. AH Care L65 is composed of a lactic acid; arginine mixture. The structure of arginine lactate is shown below.
- salt of the derivative of an amino acid we mean the cationic or anionic form of the amino acid derivative, as defined above, combined with a counter-ion, which is an ion of opposite charge.
- the cationic form of the amino acid is formed by the transfer of a positively charged hydrogen ion from an acid to an amino group in the amino acid derivative.
- the counter-ion is derived from the acid from which the hydrogen ion is transferred from.
- the anionic form of the amino acid derivative is formed by the loss of a positively charged hydrogen ion from the carboxylic acid group in the amino acid derivative. In this case the counter-ion is derived from the base to which the hydrogen ion is transferred to.
- An example of a salt of a derivative of an amino acid is N-lauroyl-L- arginine ethyl ester mono-hydrochloride which is commercially available as Aminat G whose structure is shown below.
- Salts of amino acids or amino acid derivatives used in the present invention include, but are not limited to, hydrochloride, tartrate, malonate, succinate, succinamate, malate, glutamate, pyroglutamate and aspartate.
- the salt of the amino acid or amino acid derivative is not a phosphonate salt or a phosphorus containing salt, such as a monoalkyl phosphate ion, a monoalkenyl phosphate ion, a monoalkyl phosphonate ion, or a monoalkenyl phosphonate ion, such as those having a linear or branched alkyl oralkenyl group with 8 to 20 carbon atoms.
- Component (i) may comprise a hydrophilic amino acid or a salt or a derivative of such an amino acid or a salt of such a derivative.
- Hydrophilic amino acids may have a hydrophilic side chain or may be positively or negatively charged having a hydrophilic side chain.
- Component (i) may, for example, comprise a positively charged amino acid or a salt or a derivative of such an amino acid or a salt of such a derivative.
- a derivative of an amino acid may be hydrophilic as a result of the modification made to the amino acid.
- an amino acid may be modified so that it is positively or negatively charged.
- Hydrophilic amino acids as defined above are typically water soluble.
- water soluble we mean that the amino acid or a salt or a derivative of such an amino acid or a salt of such a derivative typically have a solubility in water at 25°C of at least about 0.5 g per kg of water. For example, at least about 1 g per kg of water, such as at least about 10 g per kg of water, or at least about 50 g per kg of water.
- the salts and derivatives of amino acids and salts of such a derivative suitable for use in the present invention are typically water soluble.
- Amino acids that are suitable for use in the present invention can also be classified by their hydropathy Index. This index is described in, for example, Kyte, J. and Doolittle, R., 1982, "A simple method for displaying the hydropathic character of a protein", J mol. Biol. 157: 105-132. As the skilled reader will appreciate, the more positive the value on the Hydropathy Index, the more hydrophobic an amino acid is.
- Suitable amino acids for use in the present invention include amino acids having a Hydropathy Index value of 0 (zero) or less, such as -2 or less.
- Salts and derivatives of such amino acids and salts of such a derivative are suitable for use in the present invention.
- Arginine and its salts and derivatives and salts of such a derivative are suitable for use in the present invention.
- Arginine has a Hydropathy Index value of -4.5.
- amino acids suitable for use in the present invention can be classified by their isoelectric point (pi); that is the pH at which the net charge on the amino acid is zero. At a pH below its isoelectric point an amino acid will be positively charged. In certain compositions of the invention, it is preferred that the amino acid is positively charged. In this aspect, an amino acid that has a pi that is greater than the pH of the composition is used.
- Amino acids that are suitable for use in the present invention include those with a pi 5 or greater, such as 6 or 6.25 or greater; or 8 or 10 or greater. Salts and derivatives of such amino acids and salts of such a derivative are suitable for use in the present invention. Arginine and its salts and derivatives and salts of such a derivative are suitable for use in the present invention. Arginine has a pi of 10.76.
- Amino acids that are particularly suitable for use in the present invention include those having a hydropathy index of value of 0 (zero) or less, such as -2 or less and a pi of 6 or greater, 6.25 or greater or 8 or greater or 10 or greater. Salts and derivatives of these amino acids and salts of such a derivative are also particularly suitable for use in the present invention.
- compositions of the invention comprise chlorhexidine or a chlorhexidine salt.
- suitable chlorhexidine salts include the acetates, formates, gluconates, hydrochlorides, isoethionates, lactates, and succinamates of chlorhexidine.
- suitable salts include, but are not limited to chlorhexidine diphosphanilate, chlorhexidine digluconate, chlorhexidine diacetate, chlorhexidine dihydrochloride, chlorhexidine dichloride, chlorhexidine dihydroiodide, chlorhexidine diperchlorate, chlorhexidine dinitrate, chlorhexidine sulfate, chlorhexidine sulfite, chlorhexidine thiosulfate, chlorhexidine di-acid phosphate, chlorhexidine difluorophosphate, chlorhexidine diformate, chlorhexidine dipropionate, chlorhexidine di-iodobutyrate, chlorhexidine di-n- valerate, chlorhexidine dicaproate, chlorhexidine malonate, chlorhexidine succinate, chlorhexidine succinamate, chlorhexidine malate, chlorhexidine tartrate, chlorhexidine dimonoglycolate, chlorhexidine mono-diglycolate,
- chlorhexidine salt that may be used in the compositions of the invention is chlorhexidine di-gluconate.
- the quaternary ammonium anti-microbial agent(s) used in the present invention are typically water soluble at room temperature and pressure.
- Suitable anti-microbial quaternary ammonium compounds include compounds of formula (A) shown below. wherein R 1 and R 2 are each independently a straight chain, unsubstituted and uninterrupted Ce-12 alkyl group. In one aspect, the groups R 1 and R 2 contain the same number of carbon atoms but this is not essential and compounds in which R 1 and R 2 contain different number of carbon atoms can be used.
- X " is a halide anion such as chloride, bromide, fluoride, iodide or sulphonate, saccharinate, carbonate or bicarbonate.
- X " is not a phosphonate salt or a phosphorus containing salt, such as a monoalkyi phosphate ion, a monoalkenyl phosphate ion, a monoalkyi phosphonate ion, or a monoalkenyl phosphonate ion, such as those having a linear or branched alkyl or alkenyl group with 8 to 20 carbon atoms.
- Suitable anti-microbial quaternary ammonium compounds also include benzalkonium compounds having the formula B) shown below.
- X " is a halide anion such as chloride, bromide, fluoride, iodide, sulphonate, saccharinate, carbonate or bicarbonate.
- the compounds of formula (B) are generally called benzalkonium compounds.
- the benzalkonium chloride is provided and/or used as a mixture of Ce-ie alkyl groups, particularly a mixture of straight chain, unsusbtituted and uninterrupted alkyl groups n-CaHi7 to n-CisH37, mainly n-Ci2H25 (dodecyl), n-Ci 4 H29 (tetradecyl), and n-Ci6H33 (hexadecyl).
- each group R 1 and R 2 is independently a straight chain, unsubstituted, uninterrupted C 8 -i2 alkyl group, for example an alkyl group containing 8, 9, 10, 11 or 12 carbon atoms.
- R and R 2 may be the same, for example R 1 and R 2 may both be alkyl groups containing 8, 9, 10, 11 or 12 carbon atoms.
- benzalkonium compounds we also include derivatives of benzalkonium compounds whereby the alkyl group C m H2m+i shown below can be substituted by another organic group.
- organic groups include but are not limited to alkenyl, phenyl, amide, ester, alcohol, and ether groups or combinations thereof.
- benzalkonium compound diisobutylphenoxyethoxyethyl-dimethylbenzyl ammonium chloride, whose INCI name is benzethonium chloride (typically abbreviated to BENZ).
- BENZ benzethonium chloride
- each quaternary ammonium compound in the compositions of the invention may be the same or different.
- the anion of a compound of formula (A) may be the same or different to the anion of a compound of formula (B).
- the anion for each compound is chloride.
- composition comprises two or more anti-microbial quaternary ammonium compounds
- a compound of formula (A) and a compound of formula (B) may be present, or the composition may comprise more than one compound of formula (A) or more than one compound of formula (B).
- Examples of quaternary ammonium compounds of formula (A) include di-n-decyldimethyl ammonium chloride, octyl decyl dimethyl ammonium chloride and dioctyl dimethyl ammonium chloride.
- Examples of commercially available compounds of formula (A) include Acticide DDQ 40 from Thor, Bardac 2240 from Lonza, Bardac 2280 from Lonza and Maquat 4480E, from Mason Chemical Company, USA.
- Examples of quaternary ammonium compounds of formula (B) include N,N- benzyldimethyloctylammonium chloride, ⁇ , ⁇ -benzyldimethyldecylammonium chloride , N- dodecyl-N-benzyl-N,N-dimethylammonium chloride, N-tetradecyl-N-benzyl-N,N- dimethylammonium chloride, N-hexadecyl-N.N-dimethyl-N-benzylammonium chloride, ⁇ , ⁇ -dimethyl N-benzyl N-octadecyl ammonium chloride and mixtures thereof.
- compositions having the CAS numbers quoted above are only examples of compositions having a given CAS number that may be used in the present invention.
- the anti-microbial quaternary ammonium compound is typically not polymerised.
- Examples of commercially available compounds of formula (B) include Acticide BAC 50M from Thor, Barquat MB50/80 from Lonza, Lonzagard Benzethonium Chloride USP from Lonza.
- the anti-microbial quaternary ammonium compound or compounds used in the composition of the invention is selected from the group consisting of di-n-decyldimethyl ammonium chloride (DDAC (CAS number 7173-51-5)), benzalkonium chloride (BAC) such as benzalkonium chloride of formula (B) above wherein m is 8.
- DDAC di-n-decyldimethyl ammonium chloride
- BAC benzalkonium chloride
- This benzalkonium chloride has CAS number 68424-85-1
- BENZ benzethonium chloride
- component (i) and anti-microbial component (ii) present in the compositions of the present invention will vary depending on a number of factors, such as the intended use of composition and the particular compound(s) used.
- Anti-microbial component (ii) may consist essentially of at least one anti-microbial quaternary ammonium compound and chlorhexidine or a chlorhexidine salt.
- Anti-microbial component (ii) may consist of at least one anti-microbial quaternary ammonium compound and chlorhexidine or a chlorhexidine salt.
- anti-microbial component (ii) may consist essentially of two or more anti- microbial quaternary ammonium compounds without chlorhexidine.
- compositions of the invention may contain two or more anti-microbial quaternary ammonium compounds or at least one anti-microbial quaternary ammonium compound and chlorhexidine, or a chlorhexidine salt as the only anti-microbial compounds in the composition.
- the compositions of the invention may comprise other suitable anti-microbial agent(s) (b), such as those described in the EPA (United States Environmental Protection Agency) Listing and Annex I and Annex 3 of the EC Biocides Directive.
- the compounds included in the anti-microbial component (ii) are those that are suitable for application to the skin.
- Suitable anti-microbial agents (b) that may be included in the anti-microbial component (ii) include anti-microbial agents that are not quaternary ammonium compounds.
- these additional antimicrobial agent(s) are water soluble at room temperature and pressure.
- suitable additional antimicrobial agents include but are not limited to polymeric biguanidines (e.g. polyhexa methylene biguanidine (PHMB)), lactic acid, silver, salts of silver for example silver chloride, silver carbonate, silver citrate, silver dihydrogen citrate, octenidine HCI, amphoteric compounds, iodophores, phenolic compounds, amine anti-microbial agents and nitrogen based heterocyclic compounds, ortho phenyl phenol (OPP), and nitro bromopropanes (e.g. bronopol (INN), 2-bromo-2-nitropropane-1 ,3-diol), naturally derived biocidal compounds (e.g.
- polymeric biguanidines e.g. polyhexa methylene biguanidine (PHMB)
- PHMB polyhexa methylene biguanidine
- PHMB polyhexa methylene biguanidine
- lactic acid e.g. polyhexa
- compositions of the invention are free of inorganic antimicrobial agents such as those comprising silver.
- any additional antimicrobial agent is an organic antimicrobial agent.
- the compositions of the invention do not comprise PHMB or they may be free of polymeric biguanides. For example, they do not contain a biguanide in addition to chlorhexidine.
- the anti-microbial composition does not comprise any isothiazalones and/or any nitrobromopropanes such as bronopol and/or any hypochlorites.
- the anti-microbial composition does not contain antimicrobial compounds that are poorly soluble in water such as phenolic compounds.
- the amount of component (i) may be from about 0.0005 to 10% by weight of the composition, for example from about 0.005 to about 5% by weight of the composition, such as from about 0.01 to about 1 % by weight of the composition.
- These compositions may contain about 0.5% by weight of the composition or less of component (i), such as from 0.02 to 0.3% by weight of the composition, such as about 0.2% by weight or 0.1% by weight.
- the total amount of antimicrobial component (ii) and component (b) if present may be from about 0.001 to about 10% by weight of the composition, for example from about 0.005 to about 5% by weight of the composition, such as from about 0.01 to about 1% by weight of the composition.
- the amount of anti-microbial component (ii) may be from about 0.05 to about 0.5% by weight.
- the anti-microbial component (ii) may comprise equal amounts of quaternary ammonium compound and chlorhexidine, or salt thereof. For example, if the total amount of antimicrobial component is about 0.2% by weight of the composition, the amount of quaternary ammonium compound would be about 0.1 % and the amount of chlorhexidine, or salt thereof, would be about 0.1%. Alternatively, the anti-microbial component may comprise different amounts of quaternary ammonium compound and chlorhexidine.
- the ratio of component (i) to anti-microbial component (ii) ranges from 10: 1 to 1 : 10.
- compositions of the invention comprise a polar solvent (iii).
- Suitable polar solvents include, but are not limited to, water, alcohols, glycol ethers and mixtures thereof.
- Suitable alcohols include, but are not limited to, straight or branched chain Ci to Cs alcohols, such as methanol, ethanol, n-propanol, iso-propanol, mixtures of propanol isomers, n-butanol, sec-butanol, tert-butanol, iso-butanol, mixtures of butanol isomers, 2- methyl-1-butanol, n-pentanol, mixtures of pentanol isomers and amyl alcohol (mixture of isomers), and mixtures thereof.
- Preferred polar solvents for use in the compositions of the invention include, but are not limited to, water, ethanol, isopentydiol, mono propylene glycol, hexylene glycol, 3-Mthoxy- 3-methyl-1 -butanol (MMB), n-propanol, isopropanol, ethylene glycol ethers, propylene glycol ethers, butyl diglycol (BDG) and mixtures thereof.
- the composition comprises water or a mixture of water and one or more alcohols selected from the alcohols described above. In such mixtures, water is preferably the major component.
- the polar solvent may consist essentially of water or consist of water.
- compositions of the invention comprise an alcohol
- the alcohol is typically present in an amount lower than the amount necessary for the alcohol to provide an antimicrobial effect, but at a level that it is believed improves drying of the composition on skin.
- the compositions of the invention may comprise up to about 30% by weight alcohol, such as between 20 and 30% by weight alcohol or less than about 20% by weight alcohol, such as from about 15 to about 20% by weight alcohol.
- the percentage of alcohol may depend on the use of the composition.
- the composition of the invention when used on a wipe, may comprise up to 20% alcohol.
- the compositions of the invention are substantially free of alcohol.
- the compositions may contain 1% or less by weight alcohol.
- the compositions may contain less than 1% or less than 0.5% by weight or 0.1% by weight or less of an alcohol such as isopropanol.
- compositions of the invention may comprise no isopropanol or may comprise no alcohol.
- compositions of the invention may comprise an alcohol up to a level of 70% by weight, e.g. up to about 50% by weight.
- the composition may comprise water or a mixture of water and one or more alcohols selected from the alcohols described above. In such mixtures, water is preferably the major component.
- the polar solvent may consist of or consist essentially of water.
- the polar solvent may be water and from about 0 to about 20% by weight, such as from about 15 to about 20% by weight of an alcohol, for example ethanol or isopropanol.
- compositions of the invention can be provided in concentrated form for dilution before use or in ready to use form. It is preferred that the compositions of the invention are provided in ready to use form and, unless otherwise stated, information about amounts (such as weight% or ppm) provided in this document relate to ready to use compositions.
- a concentrate is typically provided such that when diluted the concentrate is 5 to 30% by weight, e.g. 10 or 20% by weight of resulting diluted product.
- the compositions of the invention have a concentration of amino acid component (i) of from about 0.0005 weight% to about 10 weight%, such as from about 0.005 weight% to about 5 weight%, or 0.01 weight% to 1.0 weight% and a concentration of anti-microbial component (ii) of from about 0.001 weight% to about 10 weight%, such as from about 0.005 weight% to about 5.0 weight%, or 0.01 weight% to 1 weight%.
- These compositions may contain about 0.5% by weight of the composition or less of component (i), such as from 0.02 to 0.3% by weight of the composition, such as about 0.2% by weight or 0.1% by weight.
- the pH of the compositions and formulations used can vary within wide limits, for example from about pH 2 to about pH 12, more preferably from about pH 3 to about pH 10 or about pH 4.5 to 8.
- the pH of a formulation used in the invention may be similar to that of known formulations which are intended to be used for the same purpose or a similar purpose.
- a formulation that is intended to come into contact with the skin such as a personal care or first aid formulations will typically have a pH which will not irritate the skin, for example from about pH 3 to about pH 8, such as from about pH 4.5 to about pH 7.5 or from about pH 5 to about pH 6.
- the pH of the compositions of the invention is typically from about 5 to about 6.
- compositions of the invention can comprise other ingredients commonly used in the art.
- the nature of any other ingredients used will depend on the nature and intended purpose of the composition.
- the person of ordinary skill in the art will know which additional ingredients are suitable for use in compositions for different applications.
- compositions of the present invention may comprise additional materials such as surfactants, complexing agents, buffering agents, thickening agents, skin conditioning compounds, polar solvents and fragrances.
- surfactants will depend on the nature of and the intended purpose of the composition. Suitable surfactants for use in formulations intended for different purposes will be within the knowledge of the person of ordinary skill in the art. Likewise, the selection of suitable amounts of surfactant will be within the knowledge of the person of ordinary skill in the art. Suitable surfactants may be selected from non-ionic, cationic or amphoteric and mixtures thereof.
- compositions of the invention may comprise a non-ionic surfactant.
- Suitable non-ionic surfactants include, but are not limited to, amine oxides, alkyl polyglucosides, linear and branched 1° and 2° alcohol ethoxylates, and ethoxylated/propoxylated (EOPO) block polymers.
- composition is substantially free of or free of anionic surfactant. In another aspect, the compositions of the invention do not comprise an amphoteric surfactant.
- compositions of the invention may comprise an amphoteric surfactant.
- Suitable amphoteric surfactants include but are not limited to C6-C20 alkylamphoacetates or amphodiacetates (such as cocoamphoacetates), C10-C18 alkyldimethyl betaines, C10-C18 alkyl amidopropyldimethyl betaines. Examples include but are not limited to coconut amphoteric surfactant cocoamidopropyl betaine (CAPB) (Surfac B4, CAS 61789-40-9), coco imidazoline betaine, oleo amido propyl betaine, and tall oil imidazoline.
- CAPB cocoamidopropyl betaine
- coco imidazoline betaine coco imidazoline betaine
- oleo amido propyl betaine oleo amido propyl betaine
- tall oil imidazoline tall oil imidazoline.
- compositions of the invention may comprise a cationic surfactant.
- Suitable cationic surfactants include but are not limited to undecylenamidopropyltrimonium methosulphate and cetrimonium chloride
- the amount of surfactant present in the compositions of the invention is in an amount of from about 0.01 to 20% by weight.
- the amount of surfactant depends on a number of factors such as the pH of the composition and the intended use of the composition.
- compositions of the invention may comprise complexing agents.
- sequestering agents or chelates are sometimes used interchangeably with the term complexing agents.
- complexing agents include both sequestering agents and chelates. Complexing agents can be used to help provide a clear composition even when the compositions of the invention are used with hard water.
- Suitable complexing agents include but are not limited to EDTA (Ethylenediaminetetraacetic acid), Gluconate, GLDA (Glutamic acid diacetic acid) - Trade name Dissolvine GL, EDDS (Ethylenediamine-N,N'-disuccinic acid), citrates and gluconates or salts of glutaric, adipic and succinic acids and mixtures thereof.
- the complexing agent contains a counter ion that counter ion is preferably metallic. Suitable metallic counter ions include but are not limited to Na, Ca, Fe, K, Zn, Mg and Mn.
- Preferred complexing agents are GLDA (Dissolvine) and EDTA.
- the complexing agents are typically present in an amount of from about 100 to 10,000 ppm, preferably from about 400 to 3,000 ppm, for example from about 500 to 2000ppm. Buffering agents may be included to adjust the pH of the composition to the required value and maintain it at or close to that pH value during storage and use.
- Suitable pH modifiers include but are not limited to acids such as citric, sulfamic, hydrochloric, phosphoric, nitric, lactic, formic, acetic glycolic or gluconic acids or other mineral or organic acids or bases such as sodium or potassium hydroxide, triethanolamines and carbonates and mixtures thereof. Thickening agents can be included to adjust the viscosity of the composition to the required value for such purposes as to make the composition more stable; facilitate application of the composition; or for aesthetic benefits.
- acids such as citric, sulfamic, hydrochloric, phosphoric, nitric, lactic, formic, acetic glycolic or gluconic acids or other mineral or organic acids or bases such as sodium or potassium hydroxide, triethanolamines and carbonates and mixtures thereof.
- Thickening agents can be included to adjust the viscosity of the composition to the required value for such purposes as to make the composition more stable; facilitate application of the composition; or for aesthetic benefits.
- thickening agents include but are not limited to hydroxypropylmethylcellulose stearoxy ether supplied commercially by Daido chemical corporation under the tradename Sangelose 90, and a polyquaternium 37 supplied by Rheo Lab under the tradename Kleasol 200ST.
- compositions of the invention may contain skin conditioning compounds.
- suitable skin conditioning compounds include, but are not limited to, panthenol, tocopheryl acetate, glycerine, polyquaternium compounds, PEG-7-glyceryl cocoate, and silicones and mixtures thereof.
- the compositions of the invention do not comprise m ucopolysaccharides .
- compositions of the invention may alternatively or additionally contain salts such as the halides of alkali metals or alkaline earth metals such NaCI or KCI.
- salts such as the halides of alkali metals or alkaline earth metals such NaCI or KCI.
- the use of salts can facilitate the formation of a stable composition.
- compositions of the invention may also contain other ingredients that are standard in the art such as colorants, fragrances, emollients, antioxidants and mixtures thereof.
- compositions of the invention may be free of anionic materials.
- anionic materials we do not include counterions that may for present in any of the ingredients used in the invention, such as counterions associated with a quaternary ammonium compound.
- the compositions of the invention may, for example, be free of anionic polyelectrolytes, such as high molecular weight, anionic mucomimetic polymers, polystyrene sulfonic acid polymers and cationic exchange resins.
- compositions of the invention have advantageous antimicrobial effects, and particularly when applied to the surface of skin.
- such compositions have an anti-microbial effect when initially applied to a surface (so called “wet kill”) and they can also have a residual anti-microbial effect in that they control, reduce or prevent the formation of new microbial colonies at the surface (so called “dry kill”) that may otherwise result in the formation of more persistent biofilms.
- the compositions of the invention are also resistant to washing with water and to wiping. This means that the compositions of the invention provide a residual anti-microbial effect even when the surface which has been treated is subsequently wiped and/or washed or rinsed with water.
- compositions of the invention are particularly suitable for use as skin or hand sanitizers or on other surfaces. Some compositions are suitable for use on other surfaces.
- the compositions of the invention typically provide a residual anti-microbial effect.
- compositions may be used in a wide variety of formats and applications for the purpose of skin sanitization.
- the compositions of the invention are particularly suitable for formulation into mousses, gels, creams, lotions, liquids, sprays and wipes to be used in body or skin sanitisation, such as hand sanitizers.
- the substrates used to prepare the wipes may be made of any suitable woven or non-woven material.
- Suitable wipe materials include, but are not limited to, non-woven fibrous sheet materials and those made of fibres from natural sources such as wood pulp, and viscose or other cellulose based materials, silk fibres and keratin fibres.
- the materials comprise from 1 to 100% by weight of a cellulosic material.
- 100% cellulosic materials such as viscose or wood pulp may be used.
- Other preferred materials include blends of cellulosic and non-cellulosic materials, such as blend of viscose with synthetic substrates such as polyester or polypropylene.
- Blended materials may comprise from 1 to 99.9 % by weight of a cellulosic material such as viscose, for example from 20 to 80% by weight or from 30 to 70 % by weight of a cellulosic material such as viscose.
- the compositions of the invention can be used on humans and animals for both therapeutic and non-therapeutic purposes. Examples of products for non-therapeutic uses include personal care and personal hygiene products. Examples of products for therapeutic purposes include first aid and skin care products. Compositions of the invention may also be in the form of a liquid and packed into suitable dispensers to provide a foam, mousse or spray in use. Compositions of the invention may be used for foot hygiene products, including those for direct use on the foot and those for the treatment/deodorisation of footwear, particularly sports footwear.
- compositions of the invention can also be used in other personal care products which are used for direct application on skin or hair for example soap, bath and shower products, hair care products including shampoo, and anti-dandruff shampoos, hair conditioners hair styling products such as hair mousses, gels and sprays, skincare products such as shaving products, cosmetics and products for hair removal, deodorant and antiperspirant products, baby products including baby cleaning and cleansing products such as baby bath, soaps, wipes, moisturisers, nappy rash cream, products for cleaning surfaces that have regular and high incidence of infant and baby contact.
- hair care products including shampoo, and anti-dandruff shampoos, hair conditioners hair styling products such as hair mousses, gels and sprays
- skincare products such as shaving products, cosmetics and products for hair removal, deodorant and antiperspirant products
- baby products including baby cleaning and cleansing products such as baby bath, soaps, wipes, moisturisers, nappy rash cream, products for cleaning surfaces that have regular and high incidence of infant and baby contact.
- compositions of the invention may be used as hygienic cleansers in pet products for direct application to the skin surface of the animal or its coat or fur for the purpose of eradicating or inhibiting micro-organisms which may otherwise have a detrimental effect on the animal's health, well-being or cleanliness.
- Such compositions can also be applied to materials such as surfaces which come into contact with animals and to which microorganisms may be transferred from the animal. The benefit of such applications is again to eradicate or inhibit such micro-organisms which otherwise may be transferred to another animal or human and also to control or eliminate the by-products that such organisms may produce such as malodour.
- Such pet applications may include but not be limited to stain and odour removal sprays, disinfectant sprays and wipes, outdoor hutch cleaners, cage cleaners, antibacterial cat litter tray sprays and wipes, dog shampoos and spritzers and dog ear cleaning wipes.
- compositions of the invention may be used for First Aid topical applications to skin to sanitize abrasions or wounds on the surface of the skin to prevent or deter infection, or to prevent minor infections such as athletes' foot, verruca, warts, spot/acne prevention/treatment products.
- the invention provides products for these uses, such as wound care or first aid products that comprise a composition of the invention.
- Compositions of the invention may also be used for medical applications such as sterilization of catheters, dialysis and other medical equipment; inhibiting or eradicating viruses such norovirus, polio virus or adenovirus; and prevention or eradication of persistent biofilms.
- Compositions of the invention may also be used on surfaces other than skin.
- Examples of applications of the invention to surfaces other than skin include but are not limited to: surface cleaners such as those intended for use in bathrooms, kitchens, living areas; hard floor cleaners; carpet cleaners; furniture cleaners; glass/mirror cleaners; toilet care products including solid toilet cleaners such as rim devices and those designed to be placed in the cistern; liquid toilet cleaners excluding those comprising hypochlorite bleaches; dishwashing products such as washing up liquids and preparations from dishwashing machines such as dishwashing solids (in powder or tablet format) & liquids; Laundry products such as solid detergents (in powder or tablet format); liquid detergents; fabric conditioners and "2 in 1" products comprising detergent and fabric conditioner; cleaning products intended for use outdoors such as those for cleaning for wood, stone, concrete or plastics, for example patio cleaner, garden furniture cleaners/treatments, BBQ cleaners, wall and fence cleaners/treatments; plant sprays such as those intended to remove insects such as aphides from plants; food sprays, such as those suitable for use in food preservation
- composition or formulation or component being described must contain the listed ingredient(s) but may optionally contain additional ingredients.
- Consisting essentially of” or “consists essentially of we mean that the composition or formulation or component being described must contain the listed ingredient(s) and may also contain small (for example up to 5% by weight, or up to 1 % or 0.1% by weight) of other ingredients provided that any additional ingredients do not affect the essential properties of the composition, formulation or component.
- Consisting of we mean that the composition or formulation or component being described must contain the listed ingredient(s) only.
- compositions or formulation or component being described contains less than 3% by weight, preferably less than 1%, more preferably 0.1 % or less by weight of the stated ingredient.
- compositions of the invention that are substantially free of alcohol contain less than 3% by weight of alcohol, preferably less than 1% by weight of alcohol, more preferably 0.1% or less alcohol.
- anti-microbial we mean a compound or composition that kills and/or inhibits the growth of microbes (microorganisms).
- microbiocidal is used to refer to compounds or compositions that kill microbes.
- the compositions of the invention are anti- microbial and/or microbiocidal.
- microorganisms By the term “sanitising” or “sanitizer” we mean the reducing in the total number of microbes on a surface.
- sterilising we mean the elimination of microbiological organisms to achieve asepsis (a sterile microbial environment).
- a microorganism or microbe is an organism that is microscopic (too small to be seen by the human eye). Examples of microorganisms include bacteria, fungi, yeasts, moulds, mycobacteria, algae spores, archaea and protists. Microorganisms are generally single- celled or unicellular organisms. However, as used herein, the term “microorganisms” also includes viruses.
- compositions of the invention may be anti-bacterial, anti-fungal, anti-algal, anti-sporal, anti-viral, anti-yeast and/or anti-mould.
- the compositions of the invention are particularly suitable for use against bacteria, such as E.coli.
- anti-bacterial, anti-fungal, anti-algal, anti-viral, anti-yeast and anti-mould agents are intended to refer to agents that inhibit the growth of the respective microorganisms but do not necessarily kill the microorganisms and agents that kill the respective microorganisms.
- anti-bacterial we include agents that inhibit the growth of bacteria but may not necessarily kill bacteria and bactericidal agents that do kill bacteria.
- anti-bacterial agents include myobactericides and tuberculocides.
- the compositions of the invention comprise at least one agent selected from anti-bacterial, anti-fungal, anti-algal, anti-sporal, anti-viral, anti-yeast and anti-mould agents and mixtures thereof. More preferably, the compositions of the invention comprise at least one anti-bacterial, anti-viral, anti-fungal and/or anti-mould agent.
- compositions of the invention can be effective against a wide range of organisms, including Gram negative and Gram positive bacteria, fungi, yeasts, viruses and some spore forming bacteria
- An advantage of the invention is that it is possible to prevent a broad range of microorganisms from adhering and attaching to the surface, and, therefore, from forming a biofilm. Large numerous colonies are also substantially prevented from forming. Thus, the ability of the colony to grow is substantially reduced or even prevented.
- the invention is therefore general in its control of microorganisms.
- the compositions may be used to reduce or control the formation of a biofilm.
- the compositions of the invention advantageously provide a residual antimicrobial effect whereby the antimicrobial action continues for a significant period after the initial application of the composition.
- the compositions of the invention do not need to contain materials that are highly toxic to mammals.
- the anti-microbial agents used in the anti-microbial compositions are typically well known and widely understood and tested anti-microbial agents.
- the efficacy of the known anti-microbial agents is amplified in the formulations of the invention. Therefore, anti-microbial agents that have a low toxicity can be used in the anti-microbial compositions.
- many "new" anti-microbial agents for known techniques of sanitization use "stronger", more toxic and/or little tested materials.
- the anti-microbial compositions of the invention do not contain materials that produce highly persistent residues or rinsates or products that contain heavy metals and their salts. Thus, there is a greatly reduced risk of long term hazards.
- the anti-microbial compositions of the invention do not interfere with the biochemical reproductive pathways of the micro-organisms they control. The risk of resistance build up and the development of resistant strains is, therefore, low.
- the anti-microbial compositions of the invention can have a duel effect in that not only do they provide an anti-microbial effect in use but they can also have a preservative effect on the composition. This means that it is typically not necessary to include additional preservatives in the formulations of the invention.
- compositions of the invention do not typically give surfaces to which they are applied a greasy feel.
- composition of the invention to control, reduce or prevent the formation of colonies of micro-organisms on a surface at which it is provided.
- the present invention provides a method for providing a residual antimicrobial benefit to a surface such as a hard surface or skin, which method comprises applying a composition as defined herein to that surface or skin.
- the composition may, for example, be applied to the surface or skin by spraying the composition on the surface or wiping the composition onto the surface or skin.
- a method that consists essentially of or consists of applying the composition to the surface or skin is provided.
- the surface to which the composition of the invention is applied is a surface of the body, such as skin.
- the anti-microbial compositions of the invention can typically degrade when submersed in water, to provide a rinsate/leachate of low toxicity and which has a short residence time in the environment.
- an anti-microbial composition of the invention to reduce or prevent the formation of colonies of microorganisms on a surface at which it is provided, such as skin.
- anti-microbial compositions of the invention are typically made by a process as described below.
- a process for preparing an anti-microbial composition as herein described comprising:
- the pH of the solution obtained after step (ii) may require adjusting. Therefore, the present invention also describes a process in which (iii) the pH of the solution is adjusted after step (ii).
- compositions as described in Table 1 were prepared using the method of Example 1.
- the commercially available compounds used in the compositions are listed below.
- Aminat G is a 20% solution of N-lauroyl-L-arginine ethyl ester mono hydrochloride in glycerine, supplied by Seppic, Its principal component is a salt of a derivative of the amino acid L-arginine.
- AH Care L65 is an amphoteric hydroxy complex, containing an amino acid, arginine and lactic acid. It is supplied by BASF. Both Aminat G and AH Care L65 are commercial examples that contain component (i) of the invention.
- Acticide DDQ 40 supplied by Thor contains 40% di-n-decyldimethyl ammonium chloride (DDAC). This is an example of component (ii) of the invention, being of Formula Type A.
- DDAC di-n-decyldimethyl ammonium chloride
- Chlorhexidine di-gluconate (CHDG), supplied by Evonik as a 20% solution is a further example of component (ii) of the invention. Lonzagard
- Benzethonium Chloride USP supplied by Lonza is a Benzalkonium derivative and contains 100% Diisobutylphenoxyethoxyethyl-dimethylbenzyl ammonium chloride (BENZ) otherwise known as Benzethonium Chloride. It is a further example of component (ii) of the invention.
- the polar solvent (component (iii)) was placed in a suitably sized vessel (typically of 1 litre capacity). A small amount of the polar solvent was retained to allow for final weight adjustment. The required amount of the biocide(s) (component (ii)), was then added to the vessel, with the vessel being stirred for 5 minutes after addition of each biocide before the next biocide is added. The required amount of the amino acid, derivative or salt (component (i)) was then added and the vessel stirred for a further 5 minutes. The pH was checked and was adjusted using lactic acid or sodium hydroxide solution if required. The solution was then made up to 100% by weight by adding the retained polar solvent and stirred for a final 10 minutes. The Control Samples were prepared following the same method but by leaving out one or more of the components (i), (ii) or (iii) of the invention.
- the % weights of compositional components (i) of the invention refers to the amount of the commercially available material and the % weights of component (ii) of the invention refers to the amount of the active chemical component, namely DDAC-di-n-decyldimethyl ammonium chloride; CHOG-Chlorhexidine digluconate; BEHZ-Benzethonium Chloride; or BAC-Benzalkonium Chloride.
- test sample 25 micro litres (0.025ml) of test sample was applied to a 2cm x 2cm section of Vitro-Skin (as supplied by IMS, Inc.) in duplicate in a Petri dish.
- the test sample was spread on the vitro-skin® surface with a sterile inoculation loop ensuring that approximately a 0.5 cm perimeter was left untreated to the edge.
- the test sample was allowed to dry on the vitro- skin®*2 at 20°C in an oven with the Petri dish lid left off for one hour.
- the Petri dish was then removed from the oven and a strip of polypropylene wipe saturated with a sterile tryptone/saline solution placed inside. The lid was closed and then placed back in the oven for 4 hours at 20°C.
- *2 vitro-skin® is a testing substrate that mimics the surface properties of human skin. It is a synthetic non-biological product that has been formulated to have topography, pH, critical surface tension and ionic strength that are similar to human skin. It is a well-known and used substrate for those trained in the art to evaluate the benefits of topological applications of skin-care products to skin, which includes the evaluation of biocidal efficacy of actives applied to skin.
- Formulation 1 and Control Samples 1 , 2, 3 6, 8 & 9 were made to the compositions described in Table 1 following the method described in Example 1. Samples of Formulation 1 and the Control Samples were then tested for anti-microbial efficacy using the method described in Example 2. The results of these tests are shown in Table 2 below. Table 2
- Formulation 1 also has superior anti-microbial performance compared to Controls 6 and 9 which are DDAC and CHDG used individually with Aminat G respectively, and Controls 1 and 8 which are DDAC and CHDG used individually without Aminat G respectively.
- Control 2 shows that Aminat G has no anti-microbial activity.
- Formulation 2 and Control Samples 1 , 2, 4, 6 & 7 were made to the compositions described in Table 1 following the method described in Example 1. Samples of Formulation 2 and the Control Samples were then tested for anti-microbial efficacy following the method described in Example 2. The results of these tests are shown in Table 3 below.
- composition of the invention namely DDAC combined with BAC and Aminat G has superior anti-microbial performance compared to Control 4 that does not have Aminat G (component (i) of the invention).
- Formulation 2 also has superior anti-microbial performance compared to Controls 6 and 7 which are DDAC and BAC used individually with Aminat G respectively, and Control 1 which is DDAC used alone without Aminat G. Control 2 shows that Aminat G has no anti-microbial activity.
- Formulation 3 and Control Samples 5, 10, 11 & 12 were made to the compositions described in Table 1 following the method described in Example 1. Samples of Formulation 3 and the Control Samples were then tested for anti-microbial efficacy following the method described in Example 2. The results of these tests are shown in Table 4 below.
- composition of the invention namely DDAC combined with CHDG and AH Care L65 has superior anti-microbial performance compared to Control 12 that does not have AH Care L65 (component (i) of the invention).
- Formulation 3 also has superior anti-microbial performance compared to Controls 10 and 11 which are DDAC and CHDG used individually with AH Care L65 respectively.
- Control 5 shows that AH Care L65 has no anti-microbial activity.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017551246A JP6785789B2 (ja) | 2015-04-02 | 2016-04-01 | 抗微生物性組成物 |
BR112017021002A BR112017021002B8 (pt) | 2015-04-02 | 2016-04-01 | composição antimicrobiana, uso de uma composição, método para reduzir substancialmente ou controlar a formação de colônias microbianas sobre ou em uma superfície, sanitizantes para as mãos, produto para o cuidado de ferimentos, produto para cuidado ou higiene pessoal, produto para animais domésticos, e, lenço antimicrobiano |
SG11201707755QA SG11201707755QA (en) | 2015-04-02 | 2016-04-01 | Anti-microbial composition |
EP16719113.9A EP3277086A2 (fr) | 2015-04-02 | 2016-04-01 | Composition antimicrobienne |
CN201680020804.5A CN107466207A (zh) | 2015-04-02 | 2016-04-01 | 抗微生物组合物 |
HK18105963.2A HK1246088A1 (zh) | 2015-04-02 | 2018-05-08 | 抗微生物組合物 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1505701.1 | 2015-04-02 | ||
GBGB1505701.1A GB201505701D0 (en) | 2015-04-02 | 2015-04-02 | Anti-microbial composition |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2016156869A2 true WO2016156869A2 (fr) | 2016-10-06 |
WO2016156869A3 WO2016156869A3 (fr) | 2016-11-10 |
Family
ID=53190097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2016/050932 WO2016156869A2 (fr) | 2015-04-02 | 2016-04-01 | Composition antimicrobienne |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP3277086A2 (fr) |
JP (1) | JP6785789B2 (fr) |
CN (1) | CN107466207A (fr) |
BR (1) | BR112017021002B8 (fr) |
GB (2) | GB201505701D0 (fr) |
HK (1) | HK1246088A1 (fr) |
MY (1) | MY178425A (fr) |
SG (1) | SG11201707755QA (fr) |
TW (1) | TWI626006B (fr) |
WO (1) | WO2016156869A2 (fr) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018065190A1 (fr) * | 2016-10-07 | 2018-04-12 | Unilever N.V. | Liquide désinfectant pour toilette personnelle |
WO2018111383A1 (fr) * | 2016-12-16 | 2018-06-21 | Vertellus Holdings Llc | Formulations d'amine quaternaire et leurs utilisations |
KR101913718B1 (ko) | 2016-10-28 | 2018-11-01 | 주식회사 에이치피앤씨 | 옥테니딘 및 염화벤잘코늄을 유효성분으로 포함하는 살균 및 소독용 조성물 |
WO2019036637A1 (fr) * | 2017-08-18 | 2019-02-21 | Lonza Inc. | Lingettes pré-humidifiées à propriétés virucides contre des virus non enveloppés |
WO2019104213A1 (fr) * | 2017-11-22 | 2019-05-31 | Board Of Regents, The University Of Texas System | Formulations d'antibiofilm et utilisation associée |
EP3543396A1 (fr) * | 2018-03-19 | 2019-09-25 | Green Impact Holding AG | Textile antimicrobien organique |
CN111954733A (zh) * | 2018-03-19 | 2020-11-17 | 生活保卫股份公司 | 有机抗菌纺织品 |
CN113796385A (zh) * | 2021-10-13 | 2021-12-17 | 洛阳冠银生物科技有限公司 | 一种含银离子氯己定盐类化合物及其制备方法和应用 |
US11707867B1 (en) * | 2021-07-30 | 2023-07-25 | Csr Worldwide Ok, Inc. | System for handling used packaging film in a food processing facility |
WO2024054841A3 (fr) * | 2022-09-07 | 2024-04-18 | Isp Investments Llc | Compositions antimicrobiennes aqueuses à base de polyglucoside d'alkyle |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017222965A1 (fr) * | 2016-06-24 | 2017-12-28 | Lonza Inc. | Combinaison synergique de biocides |
GB201614087D0 (en) * | 2016-08-17 | 2016-09-28 | Byotrol Plc | Anti-microbial composition |
WO2018044840A1 (fr) * | 2016-08-31 | 2018-03-08 | Cryovac, Inc. | Agents synergiques cationiques conduisant à une inhibition microbienne sur des surfaces d'aliments et sur des surfaces dures |
RU2696259C2 (ru) * | 2017-10-23 | 2019-08-01 | Общество С Ограниченной Ответственностью "Сан Системз" | Солюбилизация хлоргексидина основания, антисептическая и дезинфицирующая композиции |
SG11202009522TA (en) * | 2018-04-09 | 2020-10-29 | Rhodia Operations | Compositions and methods for long lasting disinfection |
WO2019203740A1 (fr) * | 2018-04-19 | 2019-10-24 | Ucar Dilek | Surface, air, textile, peinture, plastique, silicone et bois, polyéthylène; propriétés antimicrobiennes de métal et de dérivés |
CN112899087B (zh) * | 2018-06-22 | 2022-07-08 | 华东师范大学 | 厨房油污清洗剂 |
TWI711469B (zh) * | 2018-09-10 | 2020-12-01 | 寶齡富錦生技股份有限公司 | 抗微生物組合物及其製備方法 |
CN109169653B (zh) * | 2018-10-24 | 2020-09-29 | 湖北荷普药业股份有限公司 | 一种阳离子复合消毒液及其应用 |
WO2020112039A1 (fr) * | 2018-11-30 | 2020-06-04 | Dilcem Kimya Ve Denismanlik Ith. Ihr. San. Tic. Ltd. Sti. | Masque, pansement, culotte, soutien-gorge, mouchoir, tampon, tampon de récurage, vêtement chirurgical jetable et draps chirurgicaux jetables tissés, non tissés, en coton, en polyéthylène, en polypropylène et en polystyrène mélangés avec du coton non tissé, présentant des propriétés antimicrobiennes |
EP3968770A1 (fr) | 2019-05-17 | 2022-03-23 | Ecolab USA Inc. | Amélioration antimicrobienne d'antiseptiques pour la peau à actif cationique |
CN111616148A (zh) * | 2020-05-28 | 2020-09-04 | 江苏雪豹日化有限公司 | 一种高效消毒剂 |
GB202012191D0 (en) * | 2020-08-05 | 2020-09-16 | Byotrol Plc | Anti-microbial composition |
CN112294789B (zh) * | 2020-10-15 | 2022-06-07 | 郑涛 | 用于防治呼吸道感染的复方制剂及其应用 |
CN113100085B (zh) * | 2021-04-21 | 2023-12-22 | 铜陵博锋实业有限公司 | 一种透亮、高吸水度的淀粉猫砂及其制备工艺 |
CN115299437A (zh) * | 2021-05-06 | 2022-11-08 | 南顺商标有限公司 | 抗微生物组合物及其制备方法 |
CN115119841A (zh) * | 2022-07-29 | 2022-09-30 | 厦门兴勒贸易有限公司 | 适用于高倍稀释使用的新型壳聚糖复合型阳离子消毒剂 |
KR102536496B1 (ko) * | 2022-09-30 | 2023-06-01 | 서강대학교 산학협력단 | 공기 중 분사되는 사차 암모늄 염의 농도 측정을 위한 수동 채취기 및 이를 이용한 사차 암모늄 염 농도의 측정 방법 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1283892A (en) * | 1970-06-08 | 1972-08-02 | Irwin Irville Lubowe | Improvements in and relating to medicinal compositions for application to the skin and/or hair |
FR2258869A2 (en) * | 1974-01-24 | 1975-08-22 | Phytoderm Lab | Amino acid contg. disinfectant compsns - for topical application, contains quat ammonium salt synergist |
US4224319A (en) * | 1979-07-31 | 1980-09-23 | Ernest Marcadet | Antiseptic composition for topical application to the skin |
JP2541299B2 (ja) * | 1988-10-13 | 1996-10-09 | ライオン株式会社 | 動物用被毛処理剤組成物 |
US5374418A (en) * | 1992-02-13 | 1994-12-20 | Kao Corporation | Composition for use in oral cavity |
US6503952B2 (en) * | 1995-11-13 | 2003-01-07 | The Trustees Of Columbia University In The City Of New York | Triple antimicrobial composition |
JPH11255629A (ja) * | 1998-01-08 | 1999-09-21 | Sunstar Inc | 口腔用組成物 |
AU5087199A (en) * | 1998-06-30 | 2000-01-17 | American Medical Research, Inc. | Method of treating topical ailments |
US6444710B1 (en) * | 1998-10-27 | 2002-09-03 | Alcon Manufacturing, Ltd. | Use of certain fatty acid/amino acid soaps to enhance antimicrobial effectiveness of topically administrable pharmaceutical compositions |
JP3636611B2 (ja) * | 1999-03-19 | 2005-04-06 | 日華化学株式会社 | 殺菌消毒剤組成物 |
MXPA04001169A (es) * | 2001-08-09 | 2005-02-17 | Miret Lab | Nuevos sistemas de conservacion y su uso en preparaciones cosmeticas. |
US6656919B1 (en) * | 2002-01-11 | 2003-12-02 | Clarence L. Baugh | Method and a product for the rapid decontamination and sterilization of bacterial endospores |
US7192601B2 (en) * | 2002-01-18 | 2007-03-20 | Walker Edward B | Antimicrobial and sporicidal composition |
US20070014740A1 (en) * | 2005-07-15 | 2007-01-18 | Colgate-Palmolive Company | Oral compositions having cationic active ingredients |
WO2010000744A2 (fr) * | 2008-07-02 | 2010-01-07 | Laboratorios Miret, S.A. | Utilisation d’agents tensioactifs cationiques comme agents sporicides |
JP5469829B2 (ja) * | 2008-08-07 | 2014-04-16 | 株式会社カナエテクノス | 殺菌消毒液および殺菌消毒剤 |
GB0818869D0 (en) * | 2008-10-15 | 2008-11-19 | Byotrol Plc | Anti-microbial composition |
JP2010126525A (ja) * | 2008-12-01 | 2010-06-10 | Kao Corp | バイオフィルム中の微生物の殺菌方法 |
WO2010084052A2 (fr) * | 2009-01-22 | 2010-07-29 | Laboratorios Miret, S. A. | Utilisation de tensioactifs cationiques comme agents acaricides |
EP2536278B1 (fr) * | 2010-02-16 | 2014-11-05 | Insight Health Limited | Composition comprenant un germinant et un agent antimicrobienne |
CN104053632A (zh) * | 2011-08-26 | 2014-09-17 | 俄亥俄州大学 | 用于处理生物膜的组合物及方法 |
GB201118673D0 (en) * | 2011-10-28 | 2011-12-14 | Byotrol Plc | Anti-microbial composition |
GB2501341B (en) * | 2011-12-29 | 2014-10-22 | Byotrol Plc | Anti-microbial composition |
CN104399082A (zh) * | 2014-12-09 | 2015-03-11 | 南阳市汇博生物技术有限公司 | 一种用于创面杀菌促愈合的营养凝胶及其制备方法 |
-
2015
- 2015-04-02 GB GBGB1505701.1A patent/GB201505701D0/en not_active Ceased
-
2016
- 2016-04-01 WO PCT/GB2016/050932 patent/WO2016156869A2/fr active Application Filing
- 2016-04-01 SG SG11201707755QA patent/SG11201707755QA/en unknown
- 2016-04-01 EP EP16719113.9A patent/EP3277086A2/fr not_active Withdrawn
- 2016-04-01 CN CN201680020804.5A patent/CN107466207A/zh active Pending
- 2016-04-01 BR BR112017021002A patent/BR112017021002B8/pt not_active IP Right Cessation
- 2016-04-01 GB GB1605588.1A patent/GB2533527B/en not_active Expired - Fee Related
- 2016-04-01 JP JP2017551246A patent/JP6785789B2/ja active Active
- 2016-04-01 TW TW105110531A patent/TWI626006B/zh not_active IP Right Cessation
- 2016-04-01 MY MYPI2017703704A patent/MY178425A/en unknown
-
2018
- 2018-05-08 HK HK18105963.2A patent/HK1246088A1/zh unknown
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109803532A (zh) * | 2016-10-07 | 2019-05-24 | 荷兰联合利华有限公司 | 个人洗涤消毒液 |
WO2018065190A1 (fr) * | 2016-10-07 | 2018-04-12 | Unilever N.V. | Liquide désinfectant pour toilette personnelle |
KR101913718B1 (ko) | 2016-10-28 | 2018-11-01 | 주식회사 에이치피앤씨 | 옥테니딘 및 염화벤잘코늄을 유효성분으로 포함하는 살균 및 소독용 조성물 |
WO2018111383A1 (fr) * | 2016-12-16 | 2018-06-21 | Vertellus Holdings Llc | Formulations d'amine quaternaire et leurs utilisations |
US11825842B2 (en) | 2016-12-16 | 2023-11-28 | Aurorium Holdings Llc | Quaternary amine formulations and uses thereof |
CN111356365A (zh) * | 2017-08-18 | 2020-06-30 | 伦萨有限责任公司 | 具有针对无包膜病毒的杀病毒特性的预润湿的擦拭物 |
WO2019036637A1 (fr) * | 2017-08-18 | 2019-02-21 | Lonza Inc. | Lingettes pré-humidifiées à propriétés virucides contre des virus non enveloppés |
WO2019104213A1 (fr) * | 2017-11-22 | 2019-05-31 | Board Of Regents, The University Of Texas System | Formulations d'antibiofilm et utilisation associée |
EP3543396A1 (fr) * | 2018-03-19 | 2019-09-25 | Green Impact Holding AG | Textile antimicrobien organique |
CN111954733A (zh) * | 2018-03-19 | 2020-11-17 | 生活保卫股份公司 | 有机抗菌纺织品 |
WO2019180036A1 (fr) * | 2018-03-19 | 2019-09-26 | Livinguard Ag | Textile antimicrobien organique |
US11707867B1 (en) * | 2021-07-30 | 2023-07-25 | Csr Worldwide Ok, Inc. | System for handling used packaging film in a food processing facility |
CN113796385A (zh) * | 2021-10-13 | 2021-12-17 | 洛阳冠银生物科技有限公司 | 一种含银离子氯己定盐类化合物及其制备方法和应用 |
CN113796385B (zh) * | 2021-10-13 | 2023-05-30 | 洛阳冠银生物科技有限公司 | 一种含银离子氯己定盐类化合物及其制备方法和应用 |
WO2024054841A3 (fr) * | 2022-09-07 | 2024-04-18 | Isp Investments Llc | Compositions antimicrobiennes aqueuses à base de polyglucoside d'alkyle |
Also Published As
Publication number | Publication date |
---|---|
HK1246088A1 (zh) | 2018-09-07 |
BR112017021002B8 (pt) | 2020-06-16 |
JP6785789B2 (ja) | 2020-11-18 |
WO2016156869A3 (fr) | 2016-11-10 |
BR112017021002A2 (pt) | 2018-07-03 |
GB201505701D0 (en) | 2015-05-20 |
BR112017021002B1 (pt) | 2020-05-26 |
GB2533527A (en) | 2016-06-22 |
GB2533527B (en) | 2018-10-17 |
CN107466207A (zh) | 2017-12-12 |
EP3277086A2 (fr) | 2018-02-07 |
JP2018511607A (ja) | 2018-04-26 |
MY178425A (en) | 2020-10-13 |
TW201709819A (zh) | 2017-03-16 |
SG11201707755QA (en) | 2017-10-30 |
TWI626006B (zh) | 2018-06-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6785789B2 (ja) | 抗微生物性組成物 | |
EP3500102B1 (fr) | Composition antimicrobienne | |
JP7026060B2 (ja) | 殺生物剤の相乗的組合せ | |
AU2002255640B2 (en) | Preservative blends containing quaternary ammonium compounds | |
DK2023733T3 (en) | Low foaming enhanced biocidal hydrogen peroxide composition | |
EP3253207B1 (fr) | Procédé de désinfection d'une surface et composition appropriée pour une utilisation dans celui-ci | |
EP3393243B1 (fr) | Compositions comprenant un amide | |
WO2017112426A1 (fr) | Compositions comprenant un ester et/ou un acide | |
WO2014060755A1 (fr) | Préparations nettoyantes, aseptisantes et stérilisantes | |
US11723362B2 (en) | Broad-spectrum synergistic antimicrobial compositions | |
DK180059B1 (en) | ECO-FRIENDLY LONG-TERM PROTECTION COMPOSITIONS AND USES | |
US20240172759A1 (en) | Formulation comprising chlorite and percarbonate salts | |
US20180371369A1 (en) | Fabric treatment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 16719113 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 11201707755Q Country of ref document: SG |
|
ENP | Entry into the national phase |
Ref document number: 2017551246 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01A Ref document number: 112017021002 Country of ref document: BR |
|
ENP | Entry into the national phase |
Ref document number: 112017021002 Country of ref document: BR Kind code of ref document: A2 Effective date: 20170929 |