Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/27—Zinc; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
  • A61K8/86—Polyethers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

• the present invention relates to a dentifrice composition containing a water-soluble metal salt, which has an excellent halitosis suppression effect, is rough on the surface of a preparation over time, liquid separation is suppressed, has an excellent appearance stability, and is suitable for prevention or suppression of halitosis.
• Patent Document 1 Japanese Patent Laid-Open No. 01-153622
• Patent Document 2 Japanese Patent Laid-Open No. 02-311413 proposes a technique that improves the deodorization rate of methyl mercaptan by using modified aluminum hydroxide and improves the bad breath prevention effect.
• polyethylene glycol is used as a humectant or thickener.
• Patent Document 3 JP-T 2006-506359
• Example used for dentifrice with excellent remineralization accelerating effect Patent Document 4: Japanese Patent Laid-Open No.
• the dentifrice composition containing the metal salt has a sufficient bad breath prevention effect, and it has been desired to develop a preparation that can improve the bad breath suppression effect and can be used more effectively for bad breath prevention.
• the present invention has been made in view of the above circumstances, and provides a dentifrice composition containing a water-soluble metal salt that has an excellent halitosis suppression effect and is excellent in appearance stability due to suppression of rough skin and liquid separation over time. For the purpose.
• a water-soluble metal salt selected from a copper salt and a zinc salt is 0.01 to 1% by mass
• B a Brookfield viscosity. Highly-polymerized polyethylene glycol having a 5 W / V% aqueous solution viscosity at 25 ° C. measured by a meter of 10 mPa ⁇ s or more and a 2 W / V% aqueous solution viscosity at 25 ° C. measured by the viscometer of 800 mPa ⁇ s or less.
• the bad breath suppression effect When combined with 0.01 to 0.5% by mass, the bad breath suppression effect is improved, and the surface of the dentifrice preparation over time and liquid separation are suppressed, and good appearance stability can be provided. I found it. That is, according to the present invention, by appropriately blending the component (B) into the dentifrice composition containing the component (A), the bad breath suppression effect is high and the appearance stability is excellent, or the prevention of bad breath or The inventors have found that a dentifrice composition suitable for suppression can be obtained, and have made the present invention.
• the bad breath suppression effect of water-soluble metal salts such as copper salts and zinc salts is not sufficient, and even though highly polymerized polyethylene glycol does not have a bad breath suppression effect.
• the bad breath suppression effect derived from (A) component improves, and the external appearance of a formulation is stabilized.
• the component (A) is used in an inappropriate amount in combination with the component (A)
• the surface of the preparation becomes rough over time, the texture of the dentifrice becomes poor, liquid separation occurs, and the appearance is stable.
• the components (A) and (B) are appropriately combined, the problem described above is unexpectedly solved and the effect of suppressing bad breath is enhanced without deteriorating the appearance of the preparation.
• the effect of suppressing bad breath that has been sufficiently suppressed is not recognized, and the appearance of the preparation is stabilized over time, and the surface of the preparation is roughened by wrinkles and granular aggregates after storage at 50 ° C. for 1 month. Therefore, it is possible to provide a smooth and glossy surface, improve the texture of the dentifrice, and further suppress liquid separation.
• the effect of suppressing bad breath and appearance stability of the dentifrice composition containing component (A) is improved by the highly polymerized polyethylene glycol of component (B).
• the use of polyethylene glycol as an agent cannot be predicted.
• the present invention provides the following dentifrice composition.
• a dentifrice composition comprising 0.01 to 0.5% by mass of the following highly polymerized polyethylene glycol.
• the water-soluble metal salt of component (A) is one or more selected from copper gluconate, copper citrate, copper sulfate, copper chloride, zinc gluconate, zinc sulfate and zinc citrate
• the highly polymerized polyethylene glycol of component (B) is the following (1) or (2) (1) The viscosity of a 5 W / V% aqueous solution at 25 ° C.
• a composition can be provided.
• the dentifrice composition of the present invention has (A) a water-soluble metal salt selected from a copper salt and a zinc salt, and (B) a viscosity of 10 mPa ⁇ s of a 5 W / V% aqueous solution at 25 ° C. measured with a Brookfield viscometer. It is blended with highly polymerized polyethylene glycol which is not less than s and the viscosity of the 2 W / V% aqueous solution at 25 ° C. measured with the viscometer is not more than 800 mPa ⁇ s.
• the water-soluble metal salt of component (A) is one or more selected from water-soluble copper salts and zinc salts, such as copper gluconate, copper citrate, copper sulfate, copper chloride, zinc gluconate, Zinc sulfate, zinc citrate and the like can be mentioned, and not only anhydrides but also hydrates containing crystal water such as copper sulfate pentahydrate can be used, among which copper gluconate, copper citrate, zinc citrate In particular, copper gluconate and zinc citrate are preferred.
• water-soluble copper salts and zinc salts such as copper gluconate, copper citrate, copper sulfate, copper chloride, zinc gluconate, Zinc sulfate, zinc citrate and the like can be mentioned, and not only anhydrides but also hydrates containing crystal water such as copper sulfate pentahydrate can be used, among which copper gluconate, copper citrate, zinc citrate In particular, copper gluconate and zinc citrate are
• the blending amount of the water-soluble metal salt is 0.01 to 1% (mass%, hereinafter the same) of the whole composition from the viewpoint of suppressing bad breath, preferably 0.01 to 0.5%, more preferably. Is 0.05 to 0.3%. When 0.01% or more is blended, a sufficient halitosis suppression effect is obtained. 1% or less is suitable for preventing the dentifrice from becoming worse over time.
• the blending amount of the water-soluble copper salt of the component (A) is preferably 0.0014 to 0.5%, particularly preferably 0.007 to 0.15% of the whole composition as copper.
• the blending amount of the water-soluble zinc salt is preferably 0.0014 to 0.5%, particularly 0.007 to 0.15% of the whole composition as zinc.
• the highly polymerized polyethylene glycol (B) is a polymer compound having a structure in which ethylene glycol is polymerized, and is a 5 W / V (mass / volume (capacity))% aqueous solution at 25 ° C. measured with a Brookfield viscometer.
• the viscosity is 10 mPa ⁇ s or more, and the viscosity of a 2 W / V% aqueous solution at 25 ° C. measured with the viscometer is 800 mPa ⁇ s or less.
• highly polymerized polyethylene glycol has the following viscosity physical properties (1) or (2).
• Viscosity of 5 W / V% aqueous solution at 25 ° C. is 10 to 20,000 mPa ⁇ s
• the viscosity of the 2 W / V% aqueous solution at 25 ° C. is 800 mPa ⁇ s or less.
• more preferable highly polymerized polyethylene glycol is 5 W at 25 ° C.
• the viscosity of the / V% aqueous solution is 10 to 18,000 mPa ⁇ s, particularly 30 to 10,000 mPa ⁇ s, especially 55 to 2,000 mPa ⁇ s, more particularly 55 to 250 mPa ⁇ s.
• component (B) by using highly polymerized polyethylene glycol having a viscosity within the above specific range as component (B), the effect of suppressing bad breath derived from component (A) is improved, and the roughness of the preparation surface over time is improved. Liquid separation is suppressed, and good appearance stability is given.
• the viscosity of the 5 W / V% aqueous solution is less than 10 mPa ⁇ s, the effect of improving the texture of the dentifrice cannot be sufficiently obtained, and if the viscosity of the 2 W / V% aqueous solution exceeds 800 mPa ⁇ s, The texture decreases with time.
• component (B) As the highly polymerized polyethylene glycol of component (B), the following commercially available products can be used.
• ⁇ POLYOX WSR N-10 Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 12 to 50 mPa ⁇ s, measuring device: Brookfield RVT, rotor No. 1, rotation speed 50 rpm, measuring temperature 25 ° C., measuring time 0.5 minutes
• ⁇ POLYOX WSR N-80 Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 55 to 115 mPa ⁇ s, measuring equipment: Brookfield RVT, rotor No.
• the blending amount of the highly polymerized polyethylene glycol as the component (B) is 0.01 to 0.5% of the entire composition, preferably 0.03 to 0.2%, more preferably 0.05 to 0.1%. %. If the blending amount is less than 0.01%, a sufficient bad breath suppressing effect and a dentifrice improving effect cannot be obtained. If the amount is too large, further improvement in the effect cannot be expected, and the appearance stability of the preparation decreases, and if it exceeds 0.5%, the texture of the dentifrice cannot be maintained well and liquid separation can be suppressed. Can not.
• (A) / (B) indicating the ratio of the blending amount of the component (A) and the component (B) is preferably 0.02 to 100, more preferably 0.1 to 10, particularly preferably the mass ratio. Is 0.5 to 6, more preferably 0.5 to 2. If the (A) / (B) ratio is too small, the bad breath suppression effect may not be obtained sufficiently. If it is too large, the texture of the dentifrice will not be improved sufficiently, or liquid separation will not be sufficiently suppressed. There is a case.
• the ratio of the amount of the water-soluble copper salt of component (A) as copper and the amount of component (B) is shown (A-1 ) / (B) is preferably 0.003 to 50, and more preferably 0.07 to 3 in terms of mass ratio.
• (A-2) / (B) showing the ratio of the amount of the water-soluble zinc salt of the component (A) as zinc and the amount of the component (B) is 0.003 to 50, particularly 0.07 to 3 is preferred.
• the sustainability of the halitosis suppression effect is improved, and the metallic taste derived from the component (A) is preferably suppressed.
• the propylene glycol alginate used is not particularly limited, but the viscosity of a 1% aqueous solution (20 ° C.) measured by a Brookfield viscometer is in the range of 10 to 1,300 mPa ⁇ s, particularly 10 to 200 mPa ⁇ s. preferable.
• the blending amount of propylene glycol alginate is preferably 0.01 to 3%, more preferably 0.05 to 3% of the total composition.
• the blending ratio of the component (A) to the propylene glycol alginate (C) is preferably 0.01 to 5 by mass ratio.
• the dentifrice composition of the present invention is suitably prepared as a toothpaste, a liquid dentifrice or the like, particularly as a toothpaste.
• the well-known component normally used besides the said component can be mix
• abrasives, thickeners, binders, surfactants, sweeteners, preservatives, colorants, fragrances, active ingredients other than the above, and the like are used in normal amounts within a range that does not interfere with the effects of the present invention. Can do.
• abrasive examples include silica-based abrasives such as silica gel, precipitated silica, aluminosilicate, zirconosilicate, calcium phosphate-based abrasives such as dicalcium phosphate, aluminum hydroxide, alumina, calcium carbonate, synthetic resin-based abrasives, etc. It is done.
• the blending amount of the abrasive is usually 5 to 50%.
• thickener examples include sugar alcohols such as sorbit, xylit and erythritol, and polyhydric alcohols such as glycerin and propylene glycol.
• sugar alcohols such as sorbit, xylit and erythritol
• polyhydric alcohols such as glycerin and propylene glycol.
• the amount of these thickeners is usually 5 to 50%.
• binder examples include cellulose derivatives such as sodium carboxymethyl cellulose and gums such as xanthan gum.
• the amount of the binder is usually 0 to 5%, particularly 0.1 to 5%.
• an anionic surfactant As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be blended.
• the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate.
• nonionic surfactants include polyhydric acids such as sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, sugar alcohol fatty acid esters such as sucrose fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, and polyoxyethylene glycerin fatty acid esters.
• Examples include alcohol fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, and fatty acid alkanolamides.
• Examples of the cationic surfactant include alkylammonium type, and examples of the amphoteric surfactant include betaine type and imidazoline type.
• the blending amount of the surfactant is preferably 0.5 to 5% of the entire composition.
• Sweeteners include saccharin sodium and the like.
• the preservative include paraoxybenzoic acid esters such as methylparaben, benzoic acid or a salt thereof.
• the colorant include blue No. 1, yellow No. 4, and the like.
• Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfume and menthol) Carvone, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-l-Mentoxypropane-1
• the active ingredient known ingredients that are usually blended in dentifrice compositions can be used.
• fluorides, bactericides, anti-inflammatory agents, enzymes, plant extracts, anticalculus agents, antiplaque agents, etc. can be blended. .
• fluorides such as sodium fluoride and sodium monofluorophosphate
• nonionic fungicides such as isopropylmethylphenol
• cationic fungicides enzyme tranexamic acids such as dextranase, epsilon aminocaproic acid, allantoin, etc.
• the said active ingredient can be mix
• Dentifrice compositions (toothpastes) having the compositions shown in Tables 1 to 3 were prepared by a conventional method and evaluated by the following methods. The results are shown in Tables 1 to 3.
• the viscosity of the highly polymerized polyethylene glycol is the viscosity at 25 ° C. measured with a Brookfield viscometer (Brookfield RVT or RVF), as described above. Moreover, the viscosity of polyethylene glycol # 400 measured by the same method was less than the viscosity of (B) highly polymerized polyethylene glycol.
• A Copper gluconate; manufactured by Kanto Chemical Co., Ltd., copper gluconate
• A zinc citrate; manufactured by Kanto Chemical Co., Inc., zinc citrate
• B highly polymerized polyethylene glycol
• POLYOX WSR N-80 Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Company: 85 mPa ⁇ s (rotor No. 1, rotation speed 50 rpm, measurement time 0.5 minutes)
• POLYOX WSR N-10 Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 35 mPa ⁇ s (rotor No.
• POLYOX WSR N-750 (Dow Chemical Co., Viscosity of 5 W / V% aqueous solution: 1,100 mPa ⁇ s (Rotor No. 2, rotation speed 10 rpm, measurement time 1 minute)) POLYOX WSR N-12K (Manufactured by Dow Chemical Co., Ltd., viscosity of 2 W / V% aqueous solution: 420 mPa ⁇ s (rotor No. 1, rotation speed 10 rpm, measurement time 1 minute)) Polyethylene glycol # 400 (Average molecular weight 380 described in Sanyo Chemical Industries, Ltd., Quasi-drug raw material standard 2006) ⁇ 420)
• a dentifrice composition having the composition shown in Table 4 was prepared by a conventional method using the same raw materials as described above, and evaluated by the same method. Moreover, the sustainability of the bad breath suppression effect (bad breath suppression continuous effect) and the metallic taste suppression effect were evaluated by the following methods. The results are also shown in Table 4.
• Table 5 shows formulation examples.
• the dentifrice compositions of the formulation examples were prepared in the same manner as described above and evaluated in the same manner. As a result, the bad breath suppressing effect, the texture of the dentifrice, and the absence of liquid separation were all excellent.

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• 2016
  • 2016-02-23 JP JP2017502374A patent/JP6693504B2/ja active Active
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