WO2016084615A1 - 液状皮膚外用剤 - Google Patents

液状皮膚外用剤 Download PDF

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Publication number
WO2016084615A1
WO2016084615A1 PCT/JP2015/081871 JP2015081871W WO2016084615A1 WO 2016084615 A1 WO2016084615 A1 WO 2016084615A1 JP 2015081871 W JP2015081871 W JP 2015081871W WO 2016084615 A1 WO2016084615 A1 WO 2016084615A1
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WO
WIPO (PCT)
Prior art keywords
mass
component
content
external preparation
skin external
Prior art date
Application number
PCT/JP2015/081871
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
輝礁 松元
佳和 橋本
めぐみ 池田
森 俊裕
Original Assignee
株式会社マンダム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社マンダム filed Critical 株式会社マンダム
Priority to KR1020177004326A priority Critical patent/KR20170029619A/ko
Priority to JP2016561496A priority patent/JPWO2016084615A1/ja
Priority to CN201580043944.XA priority patent/CN106659670A/zh
Publication of WO2016084615A1 publication Critical patent/WO2016084615A1/ja

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88Polyamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25Silicon; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

Definitions

  • the present invention relates to a liquid skin external preparation.
  • a liquid skin external preparation used for cosmetics a liquid skin external preparation containing a powder in a liquid such as water or alcohol is known.
  • a lotion containing nylon powder is applied to the skin, the nylon powder remains on the skin surface after moisture has volatilized, and a smooth feeling can be obtained.
  • Such a skin lotion is used when the nylon powder settles and separates into two layers during storage, and when used, the nylon powder is shaken to disperse and then applied to the skin.
  • Patent Document 1 contains the following components (A), (B), (C), (D) and (E), and the mass ratio of ethanol to water (D) / (E) is 20/80.
  • a two-layer type cosmetic characterized in that it is ⁇ 80 / 20 is disclosed.
  • D) Ethanol E) Water
  • a component that is hardly soluble in water such as a fragrance or menthol may be added, but the component that is hardly soluble in water is adsorbed to the powder, so there is no solubilizer. Can be solubilized.
  • the solubilizing ability of the powder is insufficient, and the liquid skin external preparation
  • the liquid may become opaque and impair the appearance.
  • the present inventors studied to further improve the solubilizing ability by blending a nonionic surfactant as a solubilizer in a liquid skin external preparation containing nylon powder.
  • a nonionic surfactant is included as a solubilizing agent in the liquid skin external preparation containing nylon powder, nylon powder caking may occur.
  • the liquid skin external preparation may be separated into three layers to give an appearance. It turns out that there is a case to lose.
  • An object of the present invention is to provide a liquid skin external preparation that suppresses caking and three-layer separation and is easy to use.
  • the present invention solves the above problems, Component A: nylon powder, component B: bentonite and / or laponite, component C: organic salt and / or inorganic salt, component D: nonionic surfactant, and component E: water,
  • the content of the component A is 0.5 to 5.0% by mass
  • the content of component B is 0.4% by mass or less
  • the content of component C is 0.1 to 3.0% by mass;
  • the liquid skin external preparation whose mass ratio [(content of the said component A) / (content of the said component B)] of content of the said component A with respect to content of the said component B is 100 or less.
  • the liquid skin external preparation of the present invention is essential for component A: nylon powder, component B: bentonite and / or laponite, component C: organic salt and / or inorganic salt, component D: nonionic surfactant, and component E: water. Contains as an ingredient.
  • the liquid skin external preparation of this invention may contain components other than the said component A, component B, component C, component D, and component E.
  • liquid means that the viscosity at 25 ° C. is 3000 mPa ⁇ s or less, preferably 1 to 1000 mPa ⁇ s, more preferably 1 to 200 mPa ⁇ s.
  • the viscosity can be measured with a tuning fork type vibration viscometer.
  • each component for example, components A to D
  • content of each component means the total amount, when using 2 or more types of the same component.
  • Component A is nylon powder (also referred to as nylon powder or nylon particles).
  • Component A mainly exerts an effect of imparting a smooth feel (smooth feeling) to the skin after application.
  • a smooth feel smooth feeling
  • the smooth feeling refers to, for example, a dry feeling without stickiness.
  • Examples of the material of component A include nylon 6 and nylon 12. Of these, nylon 12 is preferred.
  • the average particle diameter of component A is not particularly limited, but is preferably 1.0 to 40.0 ⁇ m, more preferably 1.0 to 20.0 ⁇ m, and still more preferably 3.0 to 10.0 ⁇ m.
  • the average particle diameter can be measured by a laser diffraction scattering method. Specifically, it can be measured using, for example, a laser diffraction / scattering particle size distribution analyzer (LA950V2 manufactured by HORIBA).
  • LA950V2 laser diffraction / scattering particle size distribution analyzer
  • Component A can be a commercially available product.
  • Commercially available products include Aika Industry Co., Ltd., trade name “Gantz Pearl GPA-550”; Arkema Co., Ltd., trade name “Orgasol® 2002 EXD NAT COS”, and the like.
  • Component A may be used alone or in combination of two or more.
  • the content of Component A is 0.5% by mass or more, preferably 1.0% by mass or more, and preferably 1.5% by mass or more in 100% by mass of the liquid skin external preparation of the present invention from the viewpoint of obtaining a smooth feeling. Is more preferable. Further, the content of Component A is 5.0% by mass or less, preferably 4.5% by mass or less, in 100% by mass of the liquid skin external preparation of the present invention, from the viewpoint of preventing unpleasant squeakiness. 0.0 mass% or less is more preferable. That is, the content of Component A is 0.5 to 5.0% by mass in 100% by mass of the liquid skin external preparation of the present invention, preferably 1.0 to 4.5% by mass, and 1.5 to 4%. 0.0 mass% is more preferable. The content of component A is the total content of all components A in the liquid skin external preparation of the present invention. Note that the squeaky feeling means, for example, a feeling that the powder and the powder rub against each other and feel an unnatural catch.
  • Component B is bentonite and / or laponite (that is, one or both of bentonite and laponite).
  • Component B mainly exhibits the effect of suppressing Component A caking.
  • Component B may use only 1 type and may use 2 or more types.
  • the content of Component B is 0.4% by mass or less, preferably 0.3% by mass or less, and preferably 0.2% by mass in 100% by mass of the liquid skin external preparation of the present invention from the viewpoint of suppressing three-layer separation. % Or less is more preferable.
  • the lower limit of the content of Component B is not particularly limited, but from the viewpoint of suppressing caking, in 100% by mass of the liquid skin external preparation of the present invention, 0.01% by mass or more is preferable, and 0.1% by mass or more. Is more preferable. That is, the content of Component B is 0.4% by mass or less, preferably 0.01 to 0.3% by mass, and preferably 0.1 to 0.2% by mass in 100% by mass of the liquid skin external preparation of the present invention. % Is more preferable.
  • the content of component B is the total content of all components B in the liquid skin external preparation of the present invention.
  • the mass ratio of the content of component A to the content of component B [(content of component A) / (content of component B)] is 100 or less, preferably 50 or less, from the viewpoint of suppressing caking. 20 or less is more preferable, and 15 or less is more preferable. Further, the mass ratio of the content of component A to the content of component B [(content of component A) / (content of component B)] is preferably 1.0 or more from the viewpoint of improving the feeling of use. 0.0 or more is more preferable.
  • the liquid skin external preparation of the present invention may contain powders other than nylon powder (sometimes referred to as “other powders”) as long as the effects of the present invention are not impaired.
  • powders are not particularly limited, and examples include polyethylene powder, silica, polystyrene, polymethyl methacrylate (PMMA), urethane, talc, silicone powder, and hydroxyapatite.
  • the average particle size of other powders is not particularly limited, but is preferably 0.1 to 40.0 ⁇ m, more preferably 1.0 to 20.0 ⁇ m.
  • the content of the other powders in the liquid skin external preparation of the present invention is 0.01 to 100 parts by mass with respect to 100 parts by mass of the nylon powder content. 10.0 parts by mass is preferable, and 0.05 to 1.0 part by mass is more preferable.
  • Component C is an organic salt and / or an inorganic salt (that is, one or both of an organic salt and an inorganic salt).
  • Component C may use only 1 type and may use 2 or more types.
  • Component C includes metal salts (for example, monovalent metal salts, divalent or higher polyvalent metal salts, etc.) and the like.
  • metal salts include sodium salt, potassium salt, calcium salt, magnesium salt, zinc salt, ammonium salt, aluminum salt and the like.
  • zinc paraphenol sulfonate sodium chloride, potassium chloride, calcium chloride, magnesium chloride, magnesium sulfate, alum, sodium carbonate, sodium bicarbonate, potassium bicarbonate, ammonium chloride, sodium phosphate, dihydrogen phosphate
  • Examples include sodium, sodium dihydrogen phosphate, sodium citrate (trisodium citrate), disodium edetate, potassium aluminum sulfate, tetrasodium edetate, and zinc pyrrolidonecarboxylate.
  • zinc salts are preferable, and zinc pyrrolidone carboxylate (PCA zinc) and zinc paraphenol sulfonate are preferable from the viewpoint of obtaining the effect of suppressing sebum due to the liquid external preparation for skin.
  • Component C may be used alone or in combination of two or more.
  • Content of component C is 0.1 mass% or more in 100 mass% of liquid external preparations of this invention from a viewpoint of caking suppression, 0.4 mass% or more is preferable, and 0.8 mass% or more is preferable. More preferred. Moreover, content of the component C is 3.0 mass% or less in 100 mass% of liquid external preparations of this invention from a viewpoint of suppressing three-layer separation, and 2.0 mass% or less is preferable. 6 mass% or less is more preferable, and 1.2 mass% or less is further more preferable. That is, the content of Component C is 0.1 to 3.0% by mass, preferably 0.1 to 2.0% by mass, and preferably 0.4 to 1% in 100% by mass of the liquid skin external preparation of the present invention. More preferably, it is 6% by mass, and still more preferably 0.8 to 1.2% by mass. The content of component C is the total content of all components C in the liquid skin external preparation of the present invention.
  • Component D is a nonionic surfactant.
  • Component D mainly exhibits the effect of solubilizing poorly water-soluble substances such as fragrances and refreshing ingredients in the water-based composition.
  • Component D may use only 1 type and may use 2 or more types.
  • polyoxyethylene fatty acid for example, polyoxyethylene fatty acid, glycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, polyoxyethylene alkyl ether
  • examples include polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene (cured) castor oil, fatty acid alkylolamide, and the like.
  • polyoxyethylene polyoxypropylene alkyl ether and polyoxyethylene (cured) castor oil are preferable.
  • the polyoxyethylene polyoxypropylene alkyl ether include polyoxyethylene polyoxypropylene decyl tetradecyl ether.
  • the content of Component D is not particularly limited, but is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, in 100% by mass of the liquid skin external preparation of the present invention, from the viewpoint of improving the solubilization ability. .
  • the content of Component D is preferably 5.0% by mass or less, more preferably 1.0% by mass or less, in 100% by mass of the liquid skin external preparation of the present invention, from the viewpoints of caking suppression and usability. That is, the content of component D is preferably 0.01 to 5.0% by mass and more preferably 0.1 to 1.0% by mass in 100% by mass of the liquid skin external preparation of the present invention.
  • the content of component D is the total content of all components D in the liquid skin external preparation of the present invention.
  • Component E is water and is not particularly limited, but purified water is preferred.
  • the content of component E is not particularly limited, but is preferably 50.0% by mass or more, and 60.0% by mass in 100% by mass of the liquid skin external preparation of the present invention from the viewpoint of imparting a refreshing feel like water. The above is more preferable.
  • the content of component E is preferably 94.0% by mass or less, and 90.0% by mass or less, in 100% by mass of the liquid skin external preparation of the present invention, from the viewpoint of adding ethanol to impart antiseptic power. More preferably, it is more preferably 85.0% by mass or less.
  • the content of Component E is preferably 50.0 to 94.0% by mass, more preferably 60.0 to 90.0% by mass, and more preferably 60.0 to 10% by mass in 100% by mass of the liquid skin external preparation of the present invention. 85.0 mass% is more preferable.
  • the liquid skin external preparation of the present invention preferably further contains ethanol.
  • the content of ethanol is not particularly limited, but from the viewpoint of improving the feeling of use of the liquid skin external preparation and suppressing irritation to the skin, 40.0 mass% or less is preferable in 100 mass% of the liquid skin external preparation of the present invention, 35.0 mass% or less is more preferable, and 25.0 mass% or less is further more preferable.
  • the content of ethanol is not particularly limited, but from the viewpoint of improving the antiseptic power of the liquid skin external preparation and improving the solubility of the poorly water-soluble component in the liquid skin external preparation, in 100% by mass of the liquid skin external preparation of the present invention. 5.0 mass% or more is preferable, and 15.0 mass% or more is more preferable.
  • the liquid skin external preparation of the present invention may contain a fragrance.
  • a fragrance known and commonly used fragrances can be used, and in particular, known fragrances used for external preparations for skin and cosmetics are preferable.
  • flavor may use only 1 type and may use 2 or more types.
  • flavor is not specifically limited, From a viewpoint of obtaining sufficient fragrance and fragrance persistence, 0.1 mass% or more is preferable in 100 mass% of liquid skin external preparations of this invention, 0.15 mass% The above is more preferable. Moreover, 1.0 mass% or less is preferable in 100 mass% of liquid external preparations of this invention from a viewpoint of suppressing excessive aromaticity, and, as for content of a fragrance
  • the liquid skin external preparation of the present invention may contain a refreshing agent.
  • a refreshing agent a known and commonly used refreshing agent can be used, and in particular, a known refreshing agent used for an external preparation for skin and cosmetics is preferable.
  • a refreshing agent for example, a menthol, a menthol derivative (For example, a menthyl glyceryl ether, a menthyl lactate, a menthol glycoside etc.), camphor, mint oil, peppermint oil, eucalyptus oil, etc. are mentioned. From the viewpoint of versatility and cooling effect, menthol (l-menthol) is preferred. Only 1 type may be used for a refreshing agent, and 2 or more types may be used for it.
  • content of a refreshing agent is not specifically limited, From a viewpoint of obtaining sufficient refreshing feeling, 0.01 mass% or more is preferable in 100 mass% of liquid external preparations of this invention, and 0.02 mass% or more is more. preferable.
  • the content of the refreshing agent is preferably 7.0% by mass or less, more preferably 1.0% by mass or less, in 100% by mass of the liquid external preparation for skin of the present invention, from the viewpoint of suppressing an excessive refreshing feeling. 0.5 mass% or less is more preferable. That is, the content of the refreshing agent is preferably 0.01 to 7.0% by mass, more preferably 0.01 to 1.0% by mass, and more preferably 0.02 to 0.0% by mass in 100% by mass of the liquid skin external preparation of the present invention. 0.05 mass% is more preferable.
  • the liquid skin external preparation of the present invention is not particularly limited, but moisturizers, bactericides, higher alcohols, lower alcohols other than ethanol, surfactants other than component D (amphoteric surfactants, etc.), fats and oils, hydrocarbon oils, Waxes, higher fatty acids, fatty acid ester oils, sterols, viscosity modifiers, pH adjusters, inorganic pigments, dyes, antioxidants, UV absorbers, vitamins, astringents, whitening agents, animal and plant extracts, sequestering metal ions An agent or the like may be included as an optional component.
  • the liquid skin external preparation of the present invention can be produced by a conventional method.
  • the product of the present invention can be produced by adding a powder component to a container charged with a liquid component and stirring at room temperature.
  • the pH of the liquid skin external preparation of the present invention is not particularly limited, but is preferably 3.0 to 8.0, for example, and more preferably 4.0 to 7.0 at 25 ° C. from the viewpoint of influence on the human body. Adjustment of pH of the liquid skin external preparation of this invention can be implemented by adding an acid or an alkali suitably.
  • liquid skin external preparation of this invention for example, skin external preparations which give a refreshing feeling to the applied skin, such as refreshing cosmetics; Skin which gives a moisturizing feeling to the applied skin, such as moisturizing cosmetics External preparations; antiperspirant skin external preparations; fragrance skin external preparations; bactericidal skin external preparations; washing skin external preparations; sunscreen skin external preparations and the like.
  • the skin external preparation which gives a refreshing feeling is preferable.
  • the liquid skin external preparation of this invention may be any of cosmetics, quasi drugs, pharmaceuticals, and miscellaneous goods, for example.
  • the liquid skin external preparation of the present invention is used by applying to the skin. Although it does not specifically limit as an application site
  • the liquid skin external preparation of the present invention is preferably a lotion, for example. Moreover, it can also be used as a sheet cosmetic by impregnating the liquid skin external preparation of this invention which is a skin lotion into sheet base materials, such as a nonwoven fabric. Furthermore, the liquid skin external preparation of the present invention, which is a skin lotion, can also be used as a mist cosmetic used by filling a spray container (aerosol type or non-aerosol type) and spraying it in a mist form. That is, the liquid skin external preparation of the present invention is not particularly limited, but can be used in a dosage form such as lotion, mist, sheet (paper), and the like.
  • the container for filling the liquid skin external preparation of the present invention is not particularly limited.
  • a spray container, a pump container, etc. are mentioned.
  • the present invention is a liquid external preparation for skin containing nylon powder (component A) in a medium of water (component E). Since the liquid skin external preparation of this invention is liquid, there is little stickiness and a refreshing feeling of use is obtained. In addition, Component A can give a smooth feel to the skin after application. Furthermore, when applying to a face etc., the effect which suppresses the glare by sebum with the component A can be exhibited.
  • the liquid skin external preparation of the present invention further contains a nonionic surfactant (component D).
  • component D a nonionic surfactant
  • the degree of freedom increases. Furthermore, even when the liquid skin external preparation of the present invention is stored for a long time, the solubilized component does not precipitate, which is preferable.
  • the inventor has improved the dispersibility of Component A by Component D. It was presumed that this was due to the fact that the sedimentation layer of component A was caking strongly.
  • component B and component C are added to eliminate the caking problem. By blending these, it is presumed that the aggregate of component A and component B is formed, but caking of the sedimented layer is effectively suppressed. In addition, it is presumed that the formation of the aggregates is insufficient only with Component A and Component B without adding Component C, but the caking inhibiting effect cannot be obtained.
  • the present inventors after shaking the composition, in addition to the powder sedimentation layer and the water layer, the powder suspended above the water layer It was found that the phenomenon of separation into three layers occurs. Although the details are unknown, it is presumed that the foam generated when shaking is stabilized by the component D, and the component A and the component B adhere to the foam and float. When the powder floats in a layered manner in this way, the appearance as a liquid external preparation for skin is poor and the commercial value is lowered, which is a problem.
  • the present inventor has solved the above three-layer separation problem when the component A and the component B are limited to a specific blending ratio, and the settled layer and the water layer even after shaking.
  • the present invention was completed by finding that a liquid external preparation for skin having a good appearance can be obtained.
  • the liquid skin external preparation of the present invention has a good appearance and a good appearance at the time of use while having an excellent feeling of use and an excellent solubilizing ability.
  • Examples 1 to 9 and Comparative Examples 1 to 8 [Preparation of liquid skin external preparation]
  • a liquid external preparation for skin having the composition described in Table 1 was prepared by stirring and mixing with a disper mixer and subjected to the following evaluation.
  • the liquid skin external preparations of the examples all had viscosities at 25 ° C. in the range of 1 to 200 mPa ⁇ s. Further, the pH values of the liquid skin external preparations in the examples were all within the range of 4.0 to 7.0.
  • liquid skin external preparations The liquid skin external preparations prepared in each Example and each Comparative Example were evaluated as follows.
  • ⁇ Caking deterrence> The liquid skin external preparation (about 100 ml) prepared in each example and each comparative example was placed in a cylinder container [Nessler tube, Sansho Co., Ltd., Nessler colorimetric tube (100 ml), outer diameter ⁇ length: ⁇ 30 ⁇ 250 (Unit: mm)].
  • the cylinder container was left to stand for 1 week, and then shaken at a shaking width of 100 mm and a shaking speed of 100 mm / second, and the dispersion of the powder (dispersion of the powder forming the sedimented layer) was visually confirmed.
  • the caking inhibitory property was evaluated according to the following criteria. A (very good): The sedimentation layer is completely dispersed by shaking 10 times or less. ⁇ (Good): The sedimentation layer is completely dispersed by soaking 11 to 20 times. X (defect): The sedimentation layer is not completely dispersed even after 20 reciprocations.
  • Nylon powder made by Aika Kogyo Co., Ltd., trade name: Ganzpearl GPA-550, nylon 12, average particle diameter: 4.0 to 6.0 ⁇ m
  • Bentonite manufactured by Nippon Organoclay Co., Ltd., trade name: Bengel
  • Laponite manufactured by Rockwood Additives, trade name: Laponite XL21
  • PCA zinc Alignomoto Co., Ltd., trade name: AJIDEW ZN-100
  • Polyoxyethylene polyoxypropylene decyl tetradecyl ether manufactured by Nippon Surfactant Kogyo Co., Ltd., trade name: PEN-4630
  • Menthol Teakasago International Corporation, trade name: Mentor JP COS
  • Formulation Example 2 Acne (for sterilization) cosmetic (skin lotion) Ethanol 15.0% by mass Glycerin 4.0% by mass 1,3-butylene glycol 3.0% by mass Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.3% by mass PCA zinc 1.0% by mass Nylon powder 2.0% by mass Bentonite 0.2% by mass Fragrance 0.2% by mass Menthol 0.05% by mass Isopropyl methylphenol 0.1% by mass Salicylic acid 0.1% by mass Dipotassium glycyrrhizinate 0.1% by mass Citric acid 0.02% by mass Sodium citrate 0.1% by mass Metal sequestering agent Appropriate amount Preservative Appropriate amount Purified water balance Total 100.0% by mass
  • Formulation Example 3 Whitening Cosmetic (Lotion) Ethanol 10.0% by mass Glycerin 4.0% by mass 1,3-butylene glycol 3.0% by mass Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.5% by mass Xanthan gum 0.05% by mass Sodium chloride 0.2% by mass Nylon powder 2.0% by mass Bentonite 0.2% by mass Silica anhydride 0.8% by mass Fragrance 0.2% by mass L-ascorbic acid 2-glucoside 2.0% by mass Dipotassium glycyrrhizinate 0.1% by mass Citric acid 0.02% by mass Sodium citrate 0.1% by mass Metal sequestering agent Appropriate amount Preservative Appropriate amount Purified water balance Total 100.0% by mass
  • Formulation Example 4 Whitening Cosmetic (Lotion) Ethanol 10.0% by mass Glycerin 4.0% by mass 1,3-butylene glycol 3.0% by mass Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.5% by mass Xanthan gum 0.05% by mass Sodium chloride 0.2% by mass Nylon powder 2.0% by mass Bentonite 0.2% by mass Silica anhydride 0.8% by mass Fragrance 0.2% by mass Tranexamic acid 2.0% by mass Dipotassium glycyrrhizinate 0.1% by mass Citric acid 0.02% by mass Sodium citrate 0.1% by mass Metal sequestering agent Appropriate amount Preservative Appropriate amount Purified water balance Total 100.0% by mass
  • Formulation Example 5 Body Cool Cosmetic (Mist) Ethanol 40.0% by mass 1,3-butylene glycol 3.0% by mass Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.2% by mass Zinc paraphenolsulfonate 0.3% by mass Nylon powder 2.0% by mass Bentonite 0.2% by mass Silica anhydride 2.0% by mass Cross-linked polystyrene 1.0% by mass Fragrance 0.2% by mass Isopropyl methylphenol 0.1% by mass Menthol 2.0% by mass Menthyl glyceryl ether 0.3% by mass Kanfa 0.1% by mass 1,8-cineole 0.1% by mass Borneol 0.1% by mass Carboxyvinyl polymer 0.01% by mass Potassium hydroxide appropriate amount Metal sequestering agent appropriate amount Purified water balance 100.0% by mass The composition is filled in a non-aerosol type spray container to obtain a mist cosmetic.
  • the liquid skin external preparation of the present invention can be used, for example, as a lotion.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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PCT/JP2015/081871 2014-11-27 2015-11-12 液状皮膚外用剤 WO2016084615A1 (ja)

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KR1020177004326A KR20170029619A (ko) 2014-11-27 2015-11-12 액상 피부 외용제
JP2016561496A JPWO2016084615A1 (ja) 2014-11-27 2015-11-12 液状皮膚外用剤
CN201580043944.XA CN106659670A (zh) 2014-11-27 2015-11-12 液状皮肤外用剂

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020004192A1 (ja) * 2018-06-28 2020-01-02 小林製薬株式会社 イソプロピルメチルフェノールを含有する水性組成物
JP2020147537A (ja) * 2019-03-14 2020-09-17 株式会社マンダム 皮膚外用剤組成物

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