WO2016084615A1 - Liquid topical preparation for skin - Google Patents

Liquid topical preparation for skin Download PDF

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Publication number
WO2016084615A1
WO2016084615A1 PCT/JP2015/081871 JP2015081871W WO2016084615A1 WO 2016084615 A1 WO2016084615 A1 WO 2016084615A1 JP 2015081871 W JP2015081871 W JP 2015081871W WO 2016084615 A1 WO2016084615 A1 WO 2016084615A1
Authority
WO
WIPO (PCT)
Prior art keywords
mass
component
content
external preparation
skin external
Prior art date
Application number
PCT/JP2015/081871
Other languages
French (fr)
Japanese (ja)
Inventor
輝礁 松元
佳和 橋本
めぐみ 池田
森　俊裕
Original Assignee
株式会社マンダム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社マンダム filed Critical 株式会社マンダム
Priority to JP2016561496A priority Critical patent/JPWO2016084615A1/en
Priority to KR1020177004326A priority patent/KR20170029619A/en
Priority to CN201580043944.XA priority patent/CN106659670A/en
Publication of WO2016084615A1 publication Critical patent/WO2016084615A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88—Polyamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a liquid skin external preparation.
  • a liquid skin external preparation used for cosmetics a liquid skin external preparation containing a powder in a liquid such as water or alcohol is known.
  • a lotion containing nylon powder is applied to the skin, the nylon powder remains on the skin surface after moisture has volatilized, and a smooth feeling can be obtained.
  • Such a skin lotion is used when the nylon powder settles and separates into two layers during storage, and when used, the nylon powder is shaken to disperse and then applied to the skin.
  • Patent Document 1 contains the following components (A), (B), (C), (D) and (E), and the mass ratio of ethanol to water (D) / (E) is 20/80.
  • a two-layer type cosmetic characterized in that it is ⁇ 80 / 20 is disclosed.
  • D) Ethanol E) Water
  • a component that is hardly soluble in water such as a fragrance or menthol may be added, but the component that is hardly soluble in water is adsorbed to the powder, so there is no solubilizer. Can be solubilized.
  • the solubilizing ability of the powder is insufficient, and the liquid skin external preparation
  • the liquid may become opaque and impair the appearance.
  • the present inventors studied to further improve the solubilizing ability by blending a nonionic surfactant as a solubilizer in a liquid skin external preparation containing nylon powder.
  • a nonionic surfactant is included as a solubilizing agent in the liquid skin external preparation containing nylon powder, nylon powder caking may occur.
  • the liquid skin external preparation may be separated into three layers to give an appearance. It turns out that there is a case to lose.
  • An object of the present invention is to provide a liquid skin external preparation that suppresses caking and three-layer separation and is easy to use.
  • the present invention solves the above problems, Component A: nylon powder, component B: bentonite and / or laponite, component C: organic salt and / or inorganic salt, component D: nonionic surfactant, and component E: water,
  • the content of the component A is 0.5 to 5.0% by mass
  • the content of component B is 0.4% by mass or less
  • the content of component C is 0.1 to 3.0% by mass;
  • the liquid skin external preparation whose mass ratio [(content of the said component A) / (content of the said component B)] of content of the said component A with respect to content of the said component B is 100 or less.
  • the liquid skin external preparation of the present invention is essential for component A: nylon powder, component B: bentonite and / or laponite, component C: organic salt and / or inorganic salt, component D: nonionic surfactant, and component E: water. Contains as an ingredient.
  • the liquid skin external preparation of this invention may contain components other than the said component A, component B, component C, component D, and component E.
  • liquid means that the viscosity at 25 ° C. is 3000 mPa ⁇ s or less, preferably 1 to 1000 mPa ⁇ s, more preferably 1 to 200 mPa ⁇ s.
  • the viscosity can be measured with a tuning fork type vibration viscometer.
  • each component for example, components A to D
  • content of each component means the total amount, when using 2 or more types of the same component.
  • Component A is nylon powder (also referred to as nylon powder or nylon particles).
  • Component A mainly exerts an effect of imparting a smooth feel (smooth feeling) to the skin after application.
  • a smooth feel smooth feeling
  • the smooth feeling refers to, for example, a dry feeling without stickiness.
  • Examples of the material of component A include nylon 6 and nylon 12. Of these, nylon 12 is preferred.
  • the average particle diameter of component A is not particularly limited, but is preferably 1.0 to 40.0 ⁇ m, more preferably 1.0 to 20.0 ⁇ m, and still more preferably 3.0 to 10.0 ⁇ m.
  • the average particle diameter can be measured by a laser diffraction scattering method. Specifically, it can be measured using, for example, a laser diffraction / scattering particle size distribution analyzer (LA950V2 manufactured by HORIBA).
  • LA950V2 laser diffraction / scattering particle size distribution analyzer
  • Component A can be a commercially available product.
  • Commercially available products include Aika Industry Co., Ltd., trade name “Gantz Pearl GPA-550”; Arkema Co., Ltd., trade name “Orgasol® 2002 EXD NAT COS”, and the like.
  • Component A may be used alone or in combination of two or more.
  • the content of Component A is 0.5% by mass or more, preferably 1.0% by mass or more, and preferably 1.5% by mass or more in 100% by mass of the liquid skin external preparation of the present invention from the viewpoint of obtaining a smooth feeling. Is more preferable. Further, the content of Component A is 5.0% by mass or less, preferably 4.5% by mass or less, in 100% by mass of the liquid skin external preparation of the present invention, from the viewpoint of preventing unpleasant squeakiness. 0.0 mass% or less is more preferable. That is, the content of Component A is 0.5 to 5.0% by mass in 100% by mass of the liquid skin external preparation of the present invention, preferably 1.0 to 4.5% by mass, and 1.5 to 4%. 0.0 mass% is more preferable. The content of component A is the total content of all components A in the liquid skin external preparation of the present invention. Note that the squeaky feeling means, for example, a feeling that the powder and the powder rub against each other and feel an unnatural catch.
  • Component B is bentonite and / or laponite (that is, one or both of bentonite and laponite).
  • Component B mainly exhibits the effect of suppressing Component A caking.
  • Component B may use only 1 type and may use 2 or more types.
  • the content of Component B is 0.4% by mass or less, preferably 0.3% by mass or less, and preferably 0.2% by mass in 100% by mass of the liquid skin external preparation of the present invention from the viewpoint of suppressing three-layer separation. % Or less is more preferable.
  • the lower limit of the content of Component B is not particularly limited, but from the viewpoint of suppressing caking, in 100% by mass of the liquid skin external preparation of the present invention, 0.01% by mass or more is preferable, and 0.1% by mass or more. Is more preferable. That is, the content of Component B is 0.4% by mass or less, preferably 0.01 to 0.3% by mass, and preferably 0.1 to 0.2% by mass in 100% by mass of the liquid skin external preparation of the present invention. % Is more preferable.
  • the content of component B is the total content of all components B in the liquid skin external preparation of the present invention.
  • the mass ratio of the content of component A to the content of component B [(content of component A) / (content of component B)] is 100 or less, preferably 50 or less, from the viewpoint of suppressing caking. 20 or less is more preferable, and 15 or less is more preferable. Further, the mass ratio of the content of component A to the content of component B [(content of component A) / (content of component B)] is preferably 1.0 or more from the viewpoint of improving the feeling of use. 0.0 or more is more preferable.
  • the liquid skin external preparation of the present invention may contain powders other than nylon powder (sometimes referred to as “other powders”) as long as the effects of the present invention are not impaired.
  • powders are not particularly limited, and examples include polyethylene powder, silica, polystyrene, polymethyl methacrylate (PMMA), urethane, talc, silicone powder, and hydroxyapatite.
  • the average particle size of other powders is not particularly limited, but is preferably 0.1 to 40.0 ⁇ m, more preferably 1.0 to 20.0 ⁇ m.
  • the content of the other powders in the liquid skin external preparation of the present invention is 0.01 to 100 parts by mass with respect to 100 parts by mass of the nylon powder content. 10.0 parts by mass is preferable, and 0.05 to 1.0 part by mass is more preferable.
  • Component C is an organic salt and / or an inorganic salt (that is, one or both of an organic salt and an inorganic salt).
  • Component C may use only 1 type and may use 2 or more types.
  • Component C includes metal salts (for example, monovalent metal salts, divalent or higher polyvalent metal salts, etc.) and the like.
  • metal salts include sodium salt, potassium salt, calcium salt, magnesium salt, zinc salt, ammonium salt, aluminum salt and the like.
  • zinc paraphenol sulfonate sodium chloride, potassium chloride, calcium chloride, magnesium chloride, magnesium sulfate, alum, sodium carbonate, sodium bicarbonate, potassium bicarbonate, ammonium chloride, sodium phosphate, dihydrogen phosphate
  • Examples include sodium, sodium dihydrogen phosphate, sodium citrate (trisodium citrate), disodium edetate, potassium aluminum sulfate, tetrasodium edetate, and zinc pyrrolidonecarboxylate.
  • zinc salts are preferable, and zinc pyrrolidone carboxylate (PCA zinc) and zinc paraphenol sulfonate are preferable from the viewpoint of obtaining the effect of suppressing sebum due to the liquid external preparation for skin.
  • Component C may be used alone or in combination of two or more.
  • Content of component C is 0.1 mass% or more in 100 mass% of liquid external preparations of this invention from a viewpoint of caking suppression, 0.4 mass% or more is preferable, and 0.8 mass% or more is preferable. More preferred. Moreover, content of the component C is 3.0 mass% or less in 100 mass% of liquid external preparations of this invention from a viewpoint of suppressing three-layer separation, and 2.0 mass% or less is preferable. 6 mass% or less is more preferable, and 1.2 mass% or less is further more preferable. That is, the content of Component C is 0.1 to 3.0% by mass, preferably 0.1 to 2.0% by mass, and preferably 0.4 to 1% in 100% by mass of the liquid skin external preparation of the present invention. More preferably, it is 6% by mass, and still more preferably 0.8 to 1.2% by mass. The content of component C is the total content of all components C in the liquid skin external preparation of the present invention.
  • Component D is a nonionic surfactant.
  • Component D mainly exhibits the effect of solubilizing poorly water-soluble substances such as fragrances and refreshing ingredients in the water-based composition.
  • Component D may use only 1 type and may use 2 or more types.
  • polyoxyethylene fatty acid for example, polyoxyethylene fatty acid, glycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, polyoxyethylene alkyl ether
  • examples include polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene (cured) castor oil, fatty acid alkylolamide, and the like.
  • polyoxyethylene polyoxypropylene alkyl ether and polyoxyethylene (cured) castor oil are preferable.
  • the polyoxyethylene polyoxypropylene alkyl ether include polyoxyethylene polyoxypropylene decyl tetradecyl ether.
  • the content of Component D is not particularly limited, but is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, in 100% by mass of the liquid skin external preparation of the present invention, from the viewpoint of improving the solubilization ability. .
  • the content of Component D is preferably 5.0% by mass or less, more preferably 1.0% by mass or less, in 100% by mass of the liquid skin external preparation of the present invention, from the viewpoints of caking suppression and usability. That is, the content of component D is preferably 0.01 to 5.0% by mass and more preferably 0.1 to 1.0% by mass in 100% by mass of the liquid skin external preparation of the present invention.
  • the content of component D is the total content of all components D in the liquid skin external preparation of the present invention.
  • Component E is water and is not particularly limited, but purified water is preferred.
  • the content of component E is not particularly limited, but is preferably 50.0% by mass or more, and 60.0% by mass in 100% by mass of the liquid skin external preparation of the present invention from the viewpoint of imparting a refreshing feel like water. The above is more preferable.
  • the content of component E is preferably 94.0% by mass or less, and 90.0% by mass or less, in 100% by mass of the liquid skin external preparation of the present invention, from the viewpoint of adding ethanol to impart antiseptic power. More preferably, it is more preferably 85.0% by mass or less.
  • the content of Component E is preferably 50.0 to 94.0% by mass, more preferably 60.0 to 90.0% by mass, and more preferably 60.0 to 10% by mass in 100% by mass of the liquid skin external preparation of the present invention. 85.0 mass% is more preferable.
  • the liquid skin external preparation of the present invention preferably further contains ethanol.
  • the content of ethanol is not particularly limited, but from the viewpoint of improving the feeling of use of the liquid skin external preparation and suppressing irritation to the skin, 40.0 mass% or less is preferable in 100 mass% of the liquid skin external preparation of the present invention, 35.0 mass% or less is more preferable, and 25.0 mass% or less is further more preferable.
  • the content of ethanol is not particularly limited, but from the viewpoint of improving the antiseptic power of the liquid skin external preparation and improving the solubility of the poorly water-soluble component in the liquid skin external preparation, in 100% by mass of the liquid skin external preparation of the present invention. 5.0 mass% or more is preferable, and 15.0 mass% or more is more preferable.
  • the liquid skin external preparation of the present invention may contain a fragrance.
  • a fragrance known and commonly used fragrances can be used, and in particular, known fragrances used for external preparations for skin and cosmetics are preferable.
  • flavor may use only 1 type and may use 2 or more types.
  • flavor is not specifically limited, From a viewpoint of obtaining sufficient fragrance and fragrance persistence, 0.1 mass% or more is preferable in 100 mass% of liquid skin external preparations of this invention, 0.15 mass% The above is more preferable. Moreover, 1.0 mass% or less is preferable in 100 mass% of liquid external preparations of this invention from a viewpoint of suppressing excessive aromaticity, and, as for content of a fragrance
  • the liquid skin external preparation of the present invention may contain a refreshing agent.
  • a refreshing agent a known and commonly used refreshing agent can be used, and in particular, a known refreshing agent used for an external preparation for skin and cosmetics is preferable.
  • a refreshing agent for example, a menthol, a menthol derivative (For example, a menthyl glyceryl ether, a menthyl lactate, a menthol glycoside etc.), camphor, mint oil, peppermint oil, eucalyptus oil, etc. are mentioned. From the viewpoint of versatility and cooling effect, menthol (l-menthol) is preferred. Only 1 type may be used for a refreshing agent, and 2 or more types may be used for it.
  • content of a refreshing agent is not specifically limited, From a viewpoint of obtaining sufficient refreshing feeling, 0.01 mass% or more is preferable in 100 mass% of liquid external preparations of this invention, and 0.02 mass% or more is more. preferable.
  • the content of the refreshing agent is preferably 7.0% by mass or less, more preferably 1.0% by mass or less, in 100% by mass of the liquid external preparation for skin of the present invention, from the viewpoint of suppressing an excessive refreshing feeling. 0.5 mass% or less is more preferable. That is, the content of the refreshing agent is preferably 0.01 to 7.0% by mass, more preferably 0.01 to 1.0% by mass, and more preferably 0.02 to 0.0% by mass in 100% by mass of the liquid skin external preparation of the present invention. 0.05 mass% is more preferable.
  • the liquid skin external preparation of the present invention is not particularly limited, but moisturizers, bactericides, higher alcohols, lower alcohols other than ethanol, surfactants other than component D (amphoteric surfactants, etc.), fats and oils, hydrocarbon oils, Waxes, higher fatty acids, fatty acid ester oils, sterols, viscosity modifiers, pH adjusters, inorganic pigments, dyes, antioxidants, UV absorbers, vitamins, astringents, whitening agents, animal and plant extracts, sequestering metal ions An agent or the like may be included as an optional component.
  • the liquid skin external preparation of the present invention can be produced by a conventional method.
  • the product of the present invention can be produced by adding a powder component to a container charged with a liquid component and stirring at room temperature.
  • the pH of the liquid skin external preparation of the present invention is not particularly limited, but is preferably 3.0 to 8.0, for example, and more preferably 4.0 to 7.0 at 25 ° C. from the viewpoint of influence on the human body. Adjustment of pH of the liquid skin external preparation of this invention can be implemented by adding an acid or an alkali suitably.
  • liquid skin external preparation of this invention for example, skin external preparations which give a refreshing feeling to the applied skin, such as refreshing cosmetics; Skin which gives a moisturizing feeling to the applied skin, such as moisturizing cosmetics External preparations; antiperspirant skin external preparations; fragrance skin external preparations; bactericidal skin external preparations; washing skin external preparations; sunscreen skin external preparations and the like.
  • the skin external preparation which gives a refreshing feeling is preferable.
  • the liquid skin external preparation of this invention may be any of cosmetics, quasi drugs, pharmaceuticals, and miscellaneous goods, for example.
  • the liquid skin external preparation of the present invention is used by applying to the skin. Although it does not specifically limit as an application site
  • the liquid skin external preparation of the present invention is preferably a lotion, for example. Moreover, it can also be used as a sheet cosmetic by impregnating the liquid skin external preparation of this invention which is a skin lotion into sheet base materials, such as a nonwoven fabric. Furthermore, the liquid skin external preparation of the present invention, which is a skin lotion, can also be used as a mist cosmetic used by filling a spray container (aerosol type or non-aerosol type) and spraying it in a mist form. That is, the liquid skin external preparation of the present invention is not particularly limited, but can be used in a dosage form such as lotion, mist, sheet (paper), and the like.
  • the container for filling the liquid skin external preparation of the present invention is not particularly limited.
  • a spray container, a pump container, etc. are mentioned.
  • the present invention is a liquid external preparation for skin containing nylon powder (component A) in a medium of water (component E). Since the liquid skin external preparation of this invention is liquid, there is little stickiness and a refreshing feeling of use is obtained. In addition, Component A can give a smooth feel to the skin after application. Furthermore, when applying to a face etc., the effect which suppresses the glare by sebum with the component A can be exhibited.
  • the liquid skin external preparation of the present invention further contains a nonionic surfactant (component D).
  • component D a nonionic surfactant
  • the degree of freedom increases. Furthermore, even when the liquid skin external preparation of the present invention is stored for a long time, the solubilized component does not precipitate, which is preferable.
  • the inventor has improved the dispersibility of Component A by Component D. It was presumed that this was due to the fact that the sedimentation layer of component A was caking strongly.
  • component B and component C are added to eliminate the caking problem. By blending these, it is presumed that the aggregate of component A and component B is formed, but caking of the sedimented layer is effectively suppressed. In addition, it is presumed that the formation of the aggregates is insufficient only with Component A and Component B without adding Component C, but the caking inhibiting effect cannot be obtained.
  • the present inventors after shaking the composition, in addition to the powder sedimentation layer and the water layer, the powder suspended above the water layer It was found that the phenomenon of separation into three layers occurs. Although the details are unknown, it is presumed that the foam generated when shaking is stabilized by the component D, and the component A and the component B adhere to the foam and float. When the powder floats in a layered manner in this way, the appearance as a liquid external preparation for skin is poor and the commercial value is lowered, which is a problem.
  • the present inventor has solved the above three-layer separation problem when the component A and the component B are limited to a specific blending ratio, and the settled layer and the water layer even after shaking.
  • the present invention was completed by finding that a liquid external preparation for skin having a good appearance can be obtained.
  • the liquid skin external preparation of the present invention has a good appearance and a good appearance at the time of use while having an excellent feeling of use and an excellent solubilizing ability.
  • Examples 1 to 9 and Comparative Examples 1 to 8 [Preparation of liquid skin external preparation]
  • a liquid external preparation for skin having the composition described in Table 1 was prepared by stirring and mixing with a disper mixer and subjected to the following evaluation.
  • the liquid skin external preparations of the examples all had viscosities at 25 ° C. in the range of 1 to 200 mPa ⁇ s. Further, the pH values of the liquid skin external preparations in the examples were all within the range of 4.0 to 7.0.
  • liquid skin external preparations The liquid skin external preparations prepared in each Example and each Comparative Example were evaluated as follows.
  • ⁇ Caking deterrence> The liquid skin external preparation (about 100 ml) prepared in each example and each comparative example was placed in a cylinder container [Nessler tube, Sansho Co., Ltd., Nessler colorimetric tube (100 ml), outer diameter ⁇ length: ⁇ 30 ⁇ 250 (Unit: mm)].
  • the cylinder container was left to stand for 1 week, and then shaken at a shaking width of 100 mm and a shaking speed of 100 mm / second, and the dispersion of the powder (dispersion of the powder forming the sedimented layer) was visually confirmed.
  • the caking inhibitory property was evaluated according to the following criteria. A (very good): The sedimentation layer is completely dispersed by shaking 10 times or less. ⁇ (Good): The sedimentation layer is completely dispersed by soaking 11 to 20 times. X (defect): The sedimentation layer is not completely dispersed even after 20 reciprocations.
  • Nylon powder made by Aika Kogyo Co., Ltd., trade name: Ganzpearl GPA-550, nylon 12, average particle diameter: 4.0 to 6.0 ⁇ m
  • Bentonite manufactured by Nippon Organoclay Co., Ltd., trade name: Bengel
  • Laponite manufactured by Rockwood Additives, trade name: Laponite XL21
  • PCA zinc Alignomoto Co., Ltd., trade name: AJIDEW ZN-100
  • Polyoxyethylene polyoxypropylene decyl tetradecyl ether manufactured by Nippon Surfactant Kogyo Co., Ltd., trade name: PEN-4630
  • Menthol Teakasago International Corporation, trade name: Mentor JP COS
  • Formulation Example 2 Acne (for sterilization) cosmetic (skin lotion) Ethanol 15.0% by mass Glycerin 4.0% by mass 1,3-butylene glycol 3.0% by mass Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.3% by mass PCA zinc 1.0% by mass Nylon powder 2.0% by mass Bentonite 0.2% by mass Fragrance 0.2% by mass Menthol 0.05% by mass Isopropyl methylphenol 0.1% by mass Salicylic acid 0.1% by mass Dipotassium glycyrrhizinate 0.1% by mass Citric acid 0.02% by mass Sodium citrate 0.1% by mass Metal sequestering agent Appropriate amount Preservative Appropriate amount Purified water balance Total 100.0% by mass
  • Formulation Example 3 Whitening Cosmetic (Lotion) Ethanol 10.0% by mass Glycerin 4.0% by mass 1,3-butylene glycol 3.0% by mass Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.5% by mass Xanthan gum 0.05% by mass Sodium chloride 0.2% by mass Nylon powder 2.0% by mass Bentonite 0.2% by mass Silica anhydride 0.8% by mass Fragrance 0.2% by mass L-ascorbic acid 2-glucoside 2.0% by mass Dipotassium glycyrrhizinate 0.1% by mass Citric acid 0.02% by mass Sodium citrate 0.1% by mass Metal sequestering agent Appropriate amount Preservative Appropriate amount Purified water balance Total 100.0% by mass
  • Formulation Example 4 Whitening Cosmetic (Lotion) Ethanol 10.0% by mass Glycerin 4.0% by mass 1,3-butylene glycol 3.0% by mass Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.5% by mass Xanthan gum 0.05% by mass Sodium chloride 0.2% by mass Nylon powder 2.0% by mass Bentonite 0.2% by mass Silica anhydride 0.8% by mass Fragrance 0.2% by mass Tranexamic acid 2.0% by mass Dipotassium glycyrrhizinate 0.1% by mass Citric acid 0.02% by mass Sodium citrate 0.1% by mass Metal sequestering agent Appropriate amount Preservative Appropriate amount Purified water balance Total 100.0% by mass
  • Formulation Example 5 Body Cool Cosmetic (Mist) Ethanol 40.0% by mass 1,3-butylene glycol 3.0% by mass Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.2% by mass Zinc paraphenolsulfonate 0.3% by mass Nylon powder 2.0% by mass Bentonite 0.2% by mass Silica anhydride 2.0% by mass Cross-linked polystyrene 1.0% by mass Fragrance 0.2% by mass Isopropyl methylphenol 0.1% by mass Menthol 2.0% by mass Menthyl glyceryl ether 0.3% by mass Kanfa 0.1% by mass 1,8-cineole 0.1% by mass Borneol 0.1% by mass Carboxyvinyl polymer 0.01% by mass Potassium hydroxide appropriate amount Metal sequestering agent appropriate amount Purified water balance 100.0% by mass The composition is filled in a non-aerosol type spray container to obtain a mist cosmetic.
  • the liquid skin external preparation of the present invention can be used, for example, as a lotion.

Abstract

A liquid topical preparation for skin, containing component A: nylon powder, component B: bentonite and/or Laponite, component C: an organic salt and/or an inorganic salt, component D: a nonionic surfactant, and component E: water, the component A content being 0.5-5.0 mass%, the component B content being 0.4 mass% or less, the component C content being 0.1-3.0 mass%, and the mass ratio of the component A content to the component B content [(component A content)/(component B content)] being 100 or less. The liquid topical preparation for skin of the present invention can be used, for example, as a lotion.

Description

液状皮膚外用剤Liquid skin preparation
　本発明は液状皮膚外用剤に関する。 The present invention relates to a liquid skin external preparation.
　化粧料に用いられる液状皮膚外用剤として、水やアルコールなどの液体中に粉体を含有した液状皮膚外用剤が知られている。例えば、ナイロン末を含有する化粧水が皮膚に塗布されると、水分が揮発した後にナイロン末が皮膚表面に残り、さらさら感が得られることが知られている。このような化粧水は、保存時は、ナイロン末が沈降して２層に分離し、使用時は、振とうしてナイロン末を分散させた後、皮膚に塗布して使用される。 As a liquid skin external preparation used for cosmetics, a liquid skin external preparation containing a powder in a liquid such as water or alcohol is known. For example, it is known that when a lotion containing nylon powder is applied to the skin, the nylon powder remains on the skin surface after moisture has volatilized, and a smooth feeling can be obtained. Such a skin lotion is used when the nylon powder settles and separates into two layers during storage, and when used, the nylon powder is shaken to disperse and then applied to the skin.
　例えば、特許文献１には、下記成分（Ａ）、（Ｂ）、（Ｃ）、（Ｄ）及び（Ｅ）を含有し、エタノールと水の質量比（Ｄ）／（Ｅ）が２０／８０～８０／２０であることを特徴とする２層型化粧料、が開示されている。
（Ａ）有機粉体
（Ｂ）水溶性無機塩
（Ｃ）界面活性剤
（Ｄ）エタノール
（Ｅ）水 For example, Patent Document 1 contains the following components (A), (B), (C), (D) and (E), and the mass ratio of ethanol to water (D) / (E) is 20/80. A two-layer type cosmetic characterized in that it is ˜80 / 20 is disclosed.
(A) Organic powder (B) Water-soluble inorganic salt (C) Surfactant (D) Ethanol (E) Water
　このような液状皮膚外用剤においては、香料やメントールなどの水に難溶性の成分が添加される場合があるが、水に難溶性の成分は、粉体に吸着されるため、可溶化剤なしで可溶化することができる。 In such a liquid external preparation for skin, a component that is hardly soluble in water such as a fragrance or menthol may be added, but the component that is hardly soluble in water is adsorbed to the powder, so there is no solubilizer. Can be solubilized.
特開２００４－２６２８８７号公報Japanese Patent Laid-Open No. 2004-262887
　しかし、液状皮膚外用剤中において水に難溶性の成分の含有量が多い場合や、液状皮膚外用剤を長期間保存する場合には、粉体による可溶化能が不足して、液状皮膚外用剤の液が不透明となり外観を損ねる場合がある。 However, when the content of a component hardly soluble in water in the liquid skin external preparation is large or when the liquid skin external preparation is stored for a long period of time, the solubilizing ability of the powder is insufficient, and the liquid skin external preparation The liquid may become opaque and impair the appearance.
　そこで、本発明者らは、ナイロン末を含む液状皮膚外用剤中に、可溶化剤としてノニオン界面活性剤を配合することにより、可溶化能をより向上させることを検討した。その結果、液状皮膚外用剤の可溶化能は向上するものの、ナイロン末を含む液状皮膚外用剤中に、可溶化剤としてノニオン界面活性剤を含むと、ナイロン末のケーキングが生じる場合があることが分かった。また、このケーキングを抑制するために、ベントナイト及び／又はラポナイト、並びに有機塩及び／又は無機塩をさらに配合したところ、成分の含有量範囲によっては、液状皮膚外用剤が３層分離して外観を損なう場合があることが分かった。 Therefore, the present inventors studied to further improve the solubilizing ability by blending a nonionic surfactant as a solubilizer in a liquid skin external preparation containing nylon powder. As a result, although the solubilizing ability of the liquid skin external preparation is improved, if a nonionic surfactant is included as a solubilizing agent in the liquid skin external preparation containing nylon powder, nylon powder caking may occur. I understood. In addition, in order to suppress this caking, when bentonite and / or laponite, and organic salt and / or inorganic salt are further blended, depending on the content range of the components, the liquid skin external preparation may be separated into three layers to give an appearance. It turns out that there is a case to lose.
　本発明の課題は、ケーキング及び３層分離を抑制し、かつ使用感の良い液状皮膚外用剤を提供することである。 An object of the present invention is to provide a liquid skin external preparation that suppresses caking and three-layer separation and is easy to use.
　本発明は、上記課題を解決するものであり、
　成分Ａ：ナイロン末、成分Ｂ：ベントナイト及び／又はラポナイト、成分Ｃ：有機塩及び／又は無機塩、成分Ｄ：ノニオン界面活性剤、並びに成分Ｅ：水を含み、
前記成分Ａの含有量が０．５～５．０質量％であり、
前記成分Ｂの含有量が０．４質量％以下であり、
前記成分Ｃの含有量が０．１～３．０質量％であり、
前記成分Ｂの含有量に対する前記成分Ａの含有量の質量比[（前記成分Ａの含有量）／（前記成分Ｂの含有量）]が１００以下である、液状皮膚外用剤
、に関する。 The present invention solves the above problems,
Component A: nylon powder, component B: bentonite and / or laponite, component C: organic salt and / or inorganic salt, component D: nonionic surfactant, and component E: water,
The content of the component A is 0.5 to 5.0% by mass,
The content of component B is 0.4% by mass or less,
The content of component C is 0.1 to 3.0% by mass;
The liquid skin external preparation whose mass ratio [(content of the said component A) / (content of the said component B)] of content of the said component A with respect to content of the said component B is 100 or less.
　本発明によれば、ケーキング及び３層分離を抑制し、かつ使用感の良い液状皮膚外用剤を提供することができる。 According to the present invention, it is possible to provide a liquid skin external preparation that suppresses caking and three-layer separation and has a good feeling of use.
　本発明の液状皮膚外用剤は、成分Ａ：ナイロン末、成分Ｂ：ベントナイト及び／又はラポナイト、成分Ｃ：有機塩及び／又は無機塩、成分Ｄ：ノニオン界面活性剤、及び成分Ｅ：水を必須成分として含む。本発明の液状皮膚外用剤は、上記成分Ａ、成分Ｂ、成分Ｃ、成分Ｄ、及び成分Ｅ以外の成分を含んでいてもよい。 The liquid skin external preparation of the present invention is essential for component A: nylon powder, component B: bentonite and / or laponite, component C: organic salt and / or inorganic salt, component D: nonionic surfactant, and component E: water. Contains as an ingredient. The liquid skin external preparation of this invention may contain components other than the said component A, component B, component C, component D, and component E.
　本明細書において、「液状」とは、２５℃における粘度が３０００ｍＰａ・ｓ以下であり、１～１０００ｍＰａ・ｓが好ましく、１～２００ｍＰａ・ｓがより好ましい。上記粘度は、音叉型振動式粘度計により測定することができる。 In the present specification, the term “liquid” means that the viscosity at 25 ° C. is 3000 mPa · s or less, preferably 1 to 1000 mPa · s, more preferably 1 to 200 mPa · s. The viscosity can be measured with a tuning fork type vibration viscometer.
　本明細書において、各成分（例えば、成分Ａ～Ｄ）は、一種のみを用いてもよいし、二種以上を用いてもよい。なお、本明細書において、各成分の含有量は、同成分を２種以上用いる場合においては、その合計量を意味する。 In this specification, each component (for example, components A to D) may be used alone or in combination of two or more. In addition, in this specification, content of each component means the total amount, when using 2 or more types of the same component.
　成分Ａはナイロン末（ナイロン粉体、ナイロン粒子とも称する）である。本発明の液状皮膚外用剤において、成分Ａは、主に、塗布後に皮膚にさらさらとした感触（さらさら感）を付与する効果を発揮する。また、例えば顔に塗布する場合などに、ギラツキを抑制する効果を発揮しうる。なお、さらさら感とは、例えば、べたつきがなく乾いた感触をいう。 Component A is nylon powder (also referred to as nylon powder or nylon particles). In the liquid skin external preparation of the present invention, Component A mainly exerts an effect of imparting a smooth feel (smooth feeling) to the skin after application. In addition, for example, when applied to the face, an effect of suppressing glare can be exhibited. The smooth feeling refers to, for example, a dry feeling without stickiness.
　成分Ａの素材としては、例えば、ナイロン６、ナイロン１２などが挙げられる。このうち、ナイロン１２が好ましい。 Examples of the material of component A include nylon 6 and nylon 12. Of these, nylon 12 is preferred.
　成分Ａの平均粒径は、特に限定されないが、１．０～４０．０μｍが好ましく、より好ましくは１．０～２０．０μｍ、さらに好ましくは３．０～１０．０μｍである。 The average particle diameter of component A is not particularly limited, but is preferably 1.0 to 40.0 μm, more preferably 1.0 to 20.0 μm, and still more preferably 3.0 to 10.0 μm.
　本明細書において、平均粒径は、レーザ回折散乱法により測定することができる。具体的には、例えば、レーザ回折散乱式粒度分布測定装置（ＨＯＲＩＢＡ社製　ＬＡ９５０Ｖ２）を用いて測定することができる。 In the present specification, the average particle diameter can be measured by a laser diffraction scattering method. Specifically, it can be measured using, for example, a laser diffraction / scattering particle size distribution analyzer (LA950V2 manufactured by HORIBA).
　成分Ａは、市販品を用いることができる。上記市販品としては、例えば、アイカ工業株式会社製、商品名「ガンツパール　ＧＰＡ－５５０」；アルケマ株式会社製、商品名「Ｏｒｇａｓｏｌ（Ｒ）　２００２　ＥＸＤ　ＮＡＴ　ＣＯＳ」などが挙げられる。 Component A can be a commercially available product. Examples of the above-mentioned commercially available products include Aika Industry Co., Ltd., trade name “Gantz Pearl GPA-550”; Arkema Co., Ltd., trade name “Orgasol® 2002 EXD NAT COS”, and the like.
　成分Ａは、１種のみを用いてもよいし、２種以上を用いてもよい。 Component A may be used alone or in combination of two or more.
　成分Ａの含有量は、さらさら感を得る観点から、本発明の液状皮膚外用剤１００質量％中、０．５質量％以上であり、１．０質量％以上が好ましく、１．５質量％以上がより好ましい。また、成分Ａの含有量は、不快なきしみ感を防止する観点から、本発明の液状皮膚外用剤１００質量％中、５．０質量％以下であり、４．５質量％以下が好ましく、４．０質量％以下がより好ましい。即ち、成分Ａの含有量は、本発明の液状皮膚外用剤１００質量％中、０．５～５．０質量％であり、１．０～４．５質量％が好ましく、１．５～４．０質量％がより好ましい。成分Ａの含有量は、本発明の液状皮膚外用剤中の全ての成分Ａの含有量の合計量である。なお、きしみ感とは、例えば、粉と粉がこすれあい不自然な引っ掛かりを感じるような感触をいう。 The content of Component A is 0.5% by mass or more, preferably 1.0% by mass or more, and preferably 1.5% by mass or more in 100% by mass of the liquid skin external preparation of the present invention from the viewpoint of obtaining a smooth feeling. Is more preferable. Further, the content of Component A is 5.0% by mass or less, preferably 4.5% by mass or less, in 100% by mass of the liquid skin external preparation of the present invention, from the viewpoint of preventing unpleasant squeakiness. 0.0 mass% or less is more preferable. That is, the content of Component A is 0.5 to 5.0% by mass in 100% by mass of the liquid skin external preparation of the present invention, preferably 1.0 to 4.5% by mass, and 1.5 to 4%. 0.0 mass% is more preferable. The content of component A is the total content of all components A in the liquid skin external preparation of the present invention. Note that the squeaky feeling means, for example, a feeling that the powder and the powder rub against each other and feel an unnatural catch.
　成分Ｂは、ベントナイト及び／又はラポナイト（即ち、ベントナイト及びラポナイトのうちの、一方又は両方）である。本発明の液状皮膚外用剤において、成分Ｂは、主に、成分Ａのケーキングを抑制する効果を発揮する。成分Ｂは、１種のみを用いてもよいし、２種以上を用いてもよい。 Component B is bentonite and / or laponite (that is, one or both of bentonite and laponite). In the liquid skin external preparation of the present invention, Component B mainly exhibits the effect of suppressing Component A caking. Component B may use only 1 type and may use 2 or more types.
　成分Ｂの含有量は、３層分離を抑制する観点から、本発明の液状皮膚外用剤１００質量％中、０．４質量％以下であり、０．３質量％以下が好ましく、０．２質量％以下がより好ましい。また、成分Ｂの含有量の下限値は、特に限定されないが、ケーキング抑制の観点から、本発明の液状皮膚外用剤１００質量％中、０．０１質量％以上が好ましく、０．１質量％以上がより好ましい。即ち、成分Ｂの含有量は、本発明の液状皮膚外用剤１００質量％中、０．４質量％以下であり、０．０１～０．３質量％が好ましく、０．１～０．２質量％がより好ましい。成分Ｂの含有量は、本発明の液状皮膚外用剤中の全ての成分Ｂの含有量の合計量である。 The content of Component B is 0.4% by mass or less, preferably 0.3% by mass or less, and preferably 0.2% by mass in 100% by mass of the liquid skin external preparation of the present invention from the viewpoint of suppressing three-layer separation. % Or less is more preferable. Further, the lower limit of the content of Component B is not particularly limited, but from the viewpoint of suppressing caking, in 100% by mass of the liquid skin external preparation of the present invention, 0.01% by mass or more is preferable, and 0.1% by mass or more. Is more preferable. That is, the content of Component B is 0.4% by mass or less, preferably 0.01 to 0.3% by mass, and preferably 0.1 to 0.2% by mass in 100% by mass of the liquid skin external preparation of the present invention. % Is more preferable. The content of component B is the total content of all components B in the liquid skin external preparation of the present invention.
　成分Ｂの含有量に対する成分Ａの含有量の質量比[（成分Ａの含有量）／（成分Ｂの含有量）]は、ケーキングを抑制する観点から、１００以下であり、５０以下が好ましく、２０以下がより好ましく、１５以下がさらに好ましい。また、成分Ｂの含有量に対する成分Ａの含有量の質量比[（成分Ａの含有量）／（成分Ｂの含有量）]は、使用感向上の観点から、１．０以上が好ましく、２．０以上がより好ましい。 The mass ratio of the content of component A to the content of component B [(content of component A) / (content of component B)] is 100 or less, preferably 50 or less, from the viewpoint of suppressing caking. 20 or less is more preferable, and 15 or less is more preferable. Further, the mass ratio of the content of component A to the content of component B [(content of component A) / (content of component B)] is preferably 1.0 or more from the viewpoint of improving the feeling of use. 0.0 or more is more preferable.
　本発明の液状皮膚外用剤には、本発明の効果を損なわない範囲で、ナイロン末以外の粉体（「その他の粉体」と称する場合がある。）が含まれていてもよい。 The liquid skin external preparation of the present invention may contain powders other than nylon powder (sometimes referred to as “other powders”) as long as the effects of the present invention are not impaired.
　その他の粉体としては、特に限定されないが、例えば、ポリエチレン末、シリカ、ポリスチレン、ポリメチルメタクリレート（ＰＭＭＡ）、ウレタン、タルク、シリコーン末、ヒドロキシアパタイトなどが挙げられる。 Other powders are not particularly limited, and examples include polyethylene powder, silica, polystyrene, polymethyl methacrylate (PMMA), urethane, talc, silicone powder, and hydroxyapatite.
　その他の粉体の平均粒径は、特に限定されないが、０．１～４０．０μｍが好ましく、より好ましくは１．０～２０．０μｍである。 The average particle size of other powders is not particularly limited, but is preferably 0.1 to 40.0 μm, more preferably 1.0 to 20.0 μm.
　その他の粉体は、１種のみを用いてもよいし、２種以上を用いてもよい。 Other powders may be used alone or in combination of two or more.
　本発明の液状皮膚外用剤がその他の粉体を含む場合、本発明の液状皮膚外用剤中の、その他の粉体の含有量は、ナイロン末の含有量１００質量部に対して０．０１～１０．０質量部が好ましく、より好ましくは０．０５～１．０質量部である。 When the liquid skin external preparation of the present invention contains other powders, the content of the other powders in the liquid skin external preparation of the present invention is 0.01 to 100 parts by mass with respect to 100 parts by mass of the nylon powder content. 10.0 parts by mass is preferable, and 0.05 to 1.0 part by mass is more preferable.
　成分Ｃは、有機塩及び／又は無機塩（即ち、有機塩及び無機塩のうちの一方または両方）である。成分Ｃは、成分Ｂとともに、主に、成分Ａのケーキングを抑制する効果を発揮する。成分Ｃは、１種のみを用いてもよいし、２種以上を用いてもよい。 Component C is an organic salt and / or an inorganic salt (that is, one or both of an organic salt and an inorganic salt). Component C, together with Component B, mainly exhibits the effect of suppressing caking of Component A. Component C may use only 1 type and may use 2 or more types.
　成分Ｃとしては、金属塩（例えば、一価の金属塩、二価以上の多価金属塩等）などが挙げられる。上記金属塩としては、例えば、ナトリウム塩、カリウム塩、カルシウム塩、マグネシウム塩、亜鉛塩、アンモニウム塩、アルミニウム塩などが挙げられる。具体的には、パラフェノールスルホン酸亜鉛、塩化ナトリウム、塩化カリウム、塩化カルシウム、塩化マグネシウム、硫酸マグネシウム、ミョウバン、炭酸ナトリウム、炭酸水素ナトリウム、炭酸水素カリウム、塩化アンモニウム、リン酸ナトリウム、リン酸水素二ナトリウム、リン酸二水素ナトリウム、クエン酸ナトリウム（クエン酸三ナトリウム）、エデト酸二ナトリウム、硫酸アルミニウムカリウム、エデト酸四ナトリウム、ピロリドンカルボン酸亜鉛などが挙げられる。上記の中でも、液状皮膚外用剤による皮脂を抑制する効果を得られる観点から、亜鉛塩が好ましく、ピロリドンカルボン酸亜鉛（ＰＣＡ亜鉛）、パラフェノールスルホン酸亜鉛が好ましい。 Component C includes metal salts (for example, monovalent metal salts, divalent or higher polyvalent metal salts, etc.) and the like. Examples of the metal salt include sodium salt, potassium salt, calcium salt, magnesium salt, zinc salt, ammonium salt, aluminum salt and the like. Specifically, zinc paraphenol sulfonate, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, magnesium sulfate, alum, sodium carbonate, sodium bicarbonate, potassium bicarbonate, ammonium chloride, sodium phosphate, dihydrogen phosphate Examples include sodium, sodium dihydrogen phosphate, sodium citrate (trisodium citrate), disodium edetate, potassium aluminum sulfate, tetrasodium edetate, and zinc pyrrolidonecarboxylate. Among these, zinc salts are preferable, and zinc pyrrolidone carboxylate (PCA zinc) and zinc paraphenol sulfonate are preferable from the viewpoint of obtaining the effect of suppressing sebum due to the liquid external preparation for skin.
　成分Ｃは、１種のみを用いてもよいし、２種以上を用いてもよい。 Component C may be used alone or in combination of two or more.
　成分Ｃの含有量は、ケーキング抑制の観点から、本発明の液状皮膚外用剤１００質量％中、０．１質量％以上であり、０．４質量％以上が好ましく、０．８質量％以上がより好ましい。また、成分Ｃの含有量は、３層分離を抑制する観点から、本発明の液状皮膚外用剤１００質量％中、３．０質量％以下であり、２．０質量％以下が好ましく、１．６質量％以下がより好ましく、１．２質量％以下がさらに好ましい。即ち、成分Ｃの含有量は、本発明の液状皮膚外用剤１００質量％中、０．１～３．０質量％であり、０．１～２．０質量％が好ましく、０．４～１．６質量％がより好ましく、０．８～１．２質量％がさらに好ましい。成分Ｃの含有量は、本発明の液状皮膚外用剤中の全ての成分Ｃの含有量の合計量である。 Content of component C is 0.1 mass% or more in 100 mass% of liquid external preparations of this invention from a viewpoint of caking suppression, 0.4 mass% or more is preferable, and 0.8 mass% or more is preferable. More preferred. Moreover, content of the component C is 3.0 mass% or less in 100 mass% of liquid external preparations of this invention from a viewpoint of suppressing three-layer separation, and 2.0 mass% or less is preferable. 6 mass% or less is more preferable, and 1.2 mass% or less is further more preferable. That is, the content of Component C is 0.1 to 3.0% by mass, preferably 0.1 to 2.0% by mass, and preferably 0.4 to 1% in 100% by mass of the liquid skin external preparation of the present invention. More preferably, it is 6% by mass, and still more preferably 0.8 to 1.2% by mass. The content of component C is the total content of all components C in the liquid skin external preparation of the present invention.
　成分Ｄは、ノニオン界面活性剤である。成分Ｄは、主に、香料や清涼成分などの水難溶性物質を水ベースの組成中に可溶化する効果を発揮する。成分Ｄは、１種のみを用いてもよいし、２種以上を用いてもよい。 Component D is a nonionic surfactant. Component D mainly exhibits the effect of solubilizing poorly water-soluble substances such as fragrances and refreshing ingredients in the water-based composition. Component D may use only 1 type and may use 2 or more types.
　成分Ｄとしては、例えば、ポリオキシエチレン脂肪酸、グリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ショ糖脂肪酸エステル、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレン（硬化）ヒマシ油、脂肪酸アルキロールアミドなどが挙げられる。中でも、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシエチレン（硬化）ヒマシ油が好ましい。上記ポリオキシエチレンポリオキシプロピレンアルキルエーテルとしては、例えば、ポリオキシエチレンポリオキシプロピレンデシルテトラデシルエーテルが挙げられる。 As component D, for example, polyoxyethylene fatty acid, glycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, polyoxyethylene alkyl ether, Examples include polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene (cured) castor oil, fatty acid alkylolamide, and the like. Among these, polyoxyethylene polyoxypropylene alkyl ether and polyoxyethylene (cured) castor oil are preferable. Examples of the polyoxyethylene polyoxypropylene alkyl ether include polyoxyethylene polyoxypropylene decyl tetradecyl ether.
　成分Ｄの含有量は、特に限定されないが、可溶化能向上の観点から、本発明の液状皮膚外用剤１００質量％中、０．０１質量％以上が好ましく、０．１質量％以上がより好ましい。また、成分Ｄの含有量は、ケーキング抑制及び使用感の観点から、本発明の液状皮膚外用剤１００質量％中、５．０質量％以下が好ましく、１．０質量％以下がより好ましい。即ち、成分Ｄの含有量は、本発明の液状皮膚外用剤１００質量％中、０．０１～５．０質量％が好ましく、０．１～１．０質量％がより好ましい。成分Ｄの含有量は、本発明の液状皮膚外用剤中の全ての成分Ｄの含有量の合計量である。 The content of Component D is not particularly limited, but is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, in 100% by mass of the liquid skin external preparation of the present invention, from the viewpoint of improving the solubilization ability. . In addition, the content of Component D is preferably 5.0% by mass or less, more preferably 1.0% by mass or less, in 100% by mass of the liquid skin external preparation of the present invention, from the viewpoints of caking suppression and usability. That is, the content of component D is preferably 0.01 to 5.0% by mass and more preferably 0.1 to 1.0% by mass in 100% by mass of the liquid skin external preparation of the present invention. The content of component D is the total content of all components D in the liquid skin external preparation of the present invention.
　成分Ｅは水であり、特に限定されないが、精製水が好ましい。成分Ｅの含有量は、特に限定されないが、水らしいさっぱりとした感触を付与する観点から、本発明の液状皮膚外用剤１００質量％中、５０．０質量％以上が好ましく、６０．０質量％以上がより好ましい。また、成分Ｅの含有量は、エタノールを添加して防腐力を付与する観点から、本発明の液状皮膚外用剤１００質量％中、９４．０質量％以下が好ましく、９０．０質量％以下がより好ましく、８５．０質量％以下がさらに好ましい。即ち、成分Ｅの含有量は、本発明の液状皮膚外用剤１００質量％中、５０．０～９４．０質量％が好ましく、６０．０～９０．０質量％がより好ましく、６０．０～８５．０質量％がさらに好ましい。 Component E is water and is not particularly limited, but purified water is preferred. The content of component E is not particularly limited, but is preferably 50.0% by mass or more, and 60.0% by mass in 100% by mass of the liquid skin external preparation of the present invention from the viewpoint of imparting a refreshing feel like water. The above is more preferable. In addition, the content of component E is preferably 94.0% by mass or less, and 90.0% by mass or less, in 100% by mass of the liquid skin external preparation of the present invention, from the viewpoint of adding ethanol to impart antiseptic power. More preferably, it is more preferably 85.0% by mass or less. That is, the content of Component E is preferably 50.0 to 94.0% by mass, more preferably 60.0 to 90.0% by mass, and more preferably 60.0 to 10% by mass in 100% by mass of the liquid skin external preparation of the present invention. 85.0 mass% is more preferable.
　本発明の液状皮膚外用剤は、さらに、エタノールを含むことが好ましい。エタノールの含有量は、特に限定されないが、液状皮膚外用剤の使用感向上及び肌への刺激抑制の観点から、本発明の液状皮膚外用剤１００質量％中、４０．０質量％以下が好ましく、３５．０質量％以下がより好ましく、２５．０質量％以下がさらに好ましい。また、エタノールの含有量は、特に限定されないが、液状皮膚外用剤の防腐力向上及び液状皮膚外用剤中の水難溶性成分の溶解性向上の観点から、本発明の液状皮膚外用剤１００質量％中、５．０質量％以上が好ましく、１５．０質量％以上がより好ましい。 The liquid skin external preparation of the present invention preferably further contains ethanol. The content of ethanol is not particularly limited, but from the viewpoint of improving the feeling of use of the liquid skin external preparation and suppressing irritation to the skin, 40.0 mass% or less is preferable in 100 mass% of the liquid skin external preparation of the present invention, 35.0 mass% or less is more preferable, and 25.0 mass% or less is further more preferable. Further, the content of ethanol is not particularly limited, but from the viewpoint of improving the antiseptic power of the liquid skin external preparation and improving the solubility of the poorly water-soluble component in the liquid skin external preparation, in 100% by mass of the liquid skin external preparation of the present invention. 5.0 mass% or more is preferable, and 15.0 mass% or more is more preferable.
　本発明の液状皮膚外用剤は、香料を含んでいても良い。上記香料としては、公知慣用の香料を用いることが可能であり、特に、皮膚外用剤や化粧料に用いられる公知の香料が好ましい。香料は、１種のみを用いてもよいし、２種以上を用いてもよい。 The liquid skin external preparation of the present invention may contain a fragrance. As the above-mentioned fragrance, known and commonly used fragrances can be used, and in particular, known fragrances used for external preparations for skin and cosmetics are preferable. A fragrance | flavor may use only 1 type and may use 2 or more types.
　香料の含有量は、特に限定されないが、十分な芳香性および芳香持続性を得る観点から、本発明の液状皮膚外用剤１００質量％中、０．１質量％以上が好ましく、０．１５質量％以上がより好ましい。また、香料の含有量は、過度の芳香性を抑制する観点から、本発明の液状皮膚外用剤１００質量％中、１．０質量％以下が好ましく、０．５質量％以下がより好ましい。即ち、香料の含有量は、本発明の液状皮膚外用剤１００質量％中、０．１～１．０質量％が好ましく、０．１５～０．５質量％がより好ましい。 Although content of a fragrance | flavor is not specifically limited, From a viewpoint of obtaining sufficient fragrance and fragrance persistence, 0.1 mass% or more is preferable in 100 mass% of liquid skin external preparations of this invention, 0.15 mass% The above is more preferable. Moreover, 1.0 mass% or less is preferable in 100 mass% of liquid external preparations of this invention from a viewpoint of suppressing excessive aromaticity, and, as for content of a fragrance | flavor, 0.5 mass% or less is more preferable. That is, the content of the fragrance is preferably 0.1 to 1.0% by mass and more preferably 0.15 to 0.5% by mass in 100% by mass of the liquid skin external preparation of the present invention.
　本発明の液状皮膚外用剤は、清涼剤を含んでいても良い。上記清涼剤としては、公知慣用の清涼剤を用いることが可能であり、特に、皮膚外用剤や化粧料に用いられる公知の清涼剤が好ましい。上記清涼剤としては、特に限定されないが、例えば、メントール、メントール誘導体（例えば、メンチルグリセリルエーテル、メンチルラクテート、メントール配糖体など）、カンファ、ハッカ油、ペパーミント油、ユーカリプタスオイルなどが挙げられる。汎用性、清涼効果の観点から、メントール（ｌ－メントール）が好ましい。清涼剤は、１種のみを用いてもよいし、２種以上を用いてもよい。 The liquid skin external preparation of the present invention may contain a refreshing agent. As the above-mentioned refreshing agent, a known and commonly used refreshing agent can be used, and in particular, a known refreshing agent used for an external preparation for skin and cosmetics is preferable. Although it does not specifically limit as said refreshing agent, For example, a menthol, a menthol derivative (For example, a menthyl glyceryl ether, a menthyl lactate, a menthol glycoside etc.), camphor, mint oil, peppermint oil, eucalyptus oil, etc. are mentioned. From the viewpoint of versatility and cooling effect, menthol (l-menthol) is preferred. Only 1 type may be used for a refreshing agent, and 2 or more types may be used for it.
　清涼剤の含有量は、特に限定されないが、十分な清涼感を得る観点から、本発明の液状皮膚外用剤１００質量％中、０．０１質量％以上が好ましく、０．０２質量％以上がより好ましい。また、清涼剤の含有量は、過度の清涼感を抑制する観点から、本発明の液状皮膚外用剤１００質量％中、７．０質量％以下が好ましく、１．０質量％以下がより好ましく、０．５質量％以下がさらに好ましい。即ち、清涼剤の含有量は、本発明の液状皮膚外用剤１００質量％中、０．０１～７．０質量％が好ましく、０．０１～１．０質量％がより好ましく、０．０２～０．０５質量％がより好ましい。 Although content of a refreshing agent is not specifically limited, From a viewpoint of obtaining sufficient refreshing feeling, 0.01 mass% or more is preferable in 100 mass% of liquid external preparations of this invention, and 0.02 mass% or more is more. preferable. The content of the refreshing agent is preferably 7.0% by mass or less, more preferably 1.0% by mass or less, in 100% by mass of the liquid external preparation for skin of the present invention, from the viewpoint of suppressing an excessive refreshing feeling. 0.5 mass% or less is more preferable. That is, the content of the refreshing agent is preferably 0.01 to 7.0% by mass, more preferably 0.01 to 1.0% by mass, and more preferably 0.02 to 0.0% by mass in 100% by mass of the liquid skin external preparation of the present invention. 0.05 mass% is more preferable.
　本発明の液状皮膚外用剤は、特に限定されないが、保湿剤、殺菌剤、高級アルコール、エタノール以外の低級アルコール、成分Ｄ以外の界面活性剤（両性界面活性剤等）、油脂、炭化水素油、ロウ類、高級脂肪酸、脂肪酸エステル油、ステロール類、粘度調整剤、ｐＨ調整剤、無機顔料、色素、酸化防止剤、紫外線吸収剤、ビタミン類、収斂剤、美白剤、動植物抽出物、金属イオン封鎖剤などを、任意成分として含んでいても良い。 The liquid skin external preparation of the present invention is not particularly limited, but moisturizers, bactericides, higher alcohols, lower alcohols other than ethanol, surfactants other than component D (amphoteric surfactants, etc.), fats and oils, hydrocarbon oils, Waxes, higher fatty acids, fatty acid ester oils, sterols, viscosity modifiers, pH adjusters, inorganic pigments, dyes, antioxidants, UV absorbers, vitamins, astringents, whitening agents, animal and plant extracts, sequestering metal ions An agent or the like may be included as an optional component.
　本発明の液状皮膚外用剤は、常法により製造することができる。例えば、液体成分が投入された容器に粉体成分を添加し、常温で撹拌することによって、本発明品を製造することができる。 The liquid skin external preparation of the present invention can be produced by a conventional method. For example, the product of the present invention can be produced by adding a powder component to a container charged with a liquid component and stirring at room temperature.
　本発明の液状皮膚外用剤のｐＨは特に限定されないが、人体への影響の観点から２５℃において例えば３．０～８．０が好ましく、より好ましくは４．０～７．０である。本発明の液状皮膚外用剤のｐＨの調整は、酸又はアルカリを適宜添加することにより実施できる。 The pH of the liquid skin external preparation of the present invention is not particularly limited, but is preferably 3.0 to 8.0, for example, and more preferably 4.0 to 7.0 at 25 ° C. from the viewpoint of influence on the human body. Adjustment of pH of the liquid skin external preparation of this invention can be implemented by adding an acid or an alkali suitably.
　本発明の液状皮膚外用剤としては、特に限定されないが、例えば、清涼化粧料などの、塗布した肌に清涼感を与える皮膚外用剤；保湿化粧料などの、塗布した肌に保湿感を与える皮膚外用剤；制汗用皮膚外用剤；賦香用皮膚外用剤；殺菌用皮膚外用剤；洗浄用皮膚外用剤；サンスクリーン用皮膚外用剤などが挙げられる。中でも、清涼感を与える皮膚外用剤が好ましい。なお、本発明の液状皮膚外用剤は、例えば、化粧品、医薬部外品、医薬品、および雑貨のいずれであってもよい。 Although it does not specifically limit as liquid skin external preparation of this invention, For example, skin external preparations which give a refreshing feeling to the applied skin, such as refreshing cosmetics; Skin which gives a moisturizing feeling to the applied skin, such as moisturizing cosmetics External preparations; antiperspirant skin external preparations; fragrance skin external preparations; bactericidal skin external preparations; washing skin external preparations; sunscreen skin external preparations and the like. Especially, the skin external preparation which gives a refreshing feeling is preferable. In addition, the liquid skin external preparation of this invention may be any of cosmetics, quasi drugs, pharmaceuticals, and miscellaneous goods, for example.
　本発明の液状皮膚外用剤は、皮膚に塗布して用いられる。本発明の液状皮膚外用剤の適用部位としては、特に限定されないが、例えば、顔、体、頭（頭皮）などが挙げられる。中でも顔が好ましい。即ち、本発明の液状皮膚外用剤は、好ましくは、顔用の皮膚外用剤である。 The liquid skin external preparation of the present invention is used by applying to the skin. Although it does not specifically limit as an application site | part of the liquid skin external preparation of this invention, For example, a face, a body, a head (scalp) etc. are mentioned. Of these, the face is preferable. That is, the liquid skin external preparation of the present invention is preferably a facial skin external preparation.
　本発明の液状皮膚外用剤は、例えば、化粧水であることが好ましい。また、化粧水である本発明の液状皮膚外用剤を、不織布等のシート基材に含浸させることによって、シート化粧料として使用することもできる。さらに、化粧水である本発明の液状皮膚外用剤を、（エアゾール型又は非エアゾール型の）スプレー容器に充填して霧状に噴射して用いるミスト化粧料として使用することもできる。即ち、本発明の液状皮膚外用剤は、特に限定されないが、例えば、ローション、ミスト、シート（ペーパー）等の剤型で用いることができる。 The liquid skin external preparation of the present invention is preferably a lotion, for example. Moreover, it can also be used as a sheet cosmetic by impregnating the liquid skin external preparation of this invention which is a skin lotion into sheet base materials, such as a nonwoven fabric. Furthermore, the liquid skin external preparation of the present invention, which is a skin lotion, can also be used as a mist cosmetic used by filling a spray container (aerosol type or non-aerosol type) and spraying it in a mist form. That is, the liquid skin external preparation of the present invention is not particularly limited, but can be used in a dosage form such as lotion, mist, sheet (paper), and the like.
　本発明の液状皮膚外用剤を製品とする際に、本発明の液状皮膚外用剤を充填する容器としては、特に限定されず、例えば、ヒンジボトル、スクリューボトル、（エアゾール型又は非エアゾール型の）スプレー容器、ポンプ容器等が挙げられる。 When the liquid skin external preparation of the present invention is used as a product, the container for filling the liquid skin external preparation of the present invention is not particularly limited. For example, a hinge bottle, a screw bottle, (aerosol type or non-aerosol type) A spray container, a pump container, etc. are mentioned.
　本発明は、水（成分Ｅ）の媒体中にナイロン末（成分Ａ）を含有させた液状皮膚外用剤である。本発明の液状皮膚外用剤は、液状であるため、べたつきが少なく、さっぱりとした使用感が得られる。また、成分Ａにより、塗布後の皮膚にさらさらとした感触を付与することができる。さらに、顔などに塗布する場合には、成分Ａにより、皮脂によるギラツキを抑える効果も発揮しうる。 The present invention is a liquid external preparation for skin containing nylon powder (component A) in a medium of water (component E). Since the liquid skin external preparation of this invention is liquid, there is little stickiness and a refreshing feeling of use is obtained. In addition, Component A can give a smooth feel to the skin after application. Furthermore, when applying to a face etc., the effect which suppresses the glare by sebum with the component A can be exhibited.
　本発明の液状皮膚外用剤は、さらにノニオン界面活性剤（成分Ｄ）を含む。これにより、本発明の液状皮膚外用剤の、香料や清涼剤などの水に難溶性の成分を可溶化する能力が向上するため、本発明の液状皮膚外用剤中への、様々な成分の配合の自由度が向上する。さらに、本発明の液状皮膚外用剤を長時間保管した際にも、可溶化させた成分の析出が生じないため好ましい。 The liquid skin external preparation of the present invention further contains a nonionic surfactant (component D). This improves the ability of the liquid skin external preparation of the present invention to solubilize components that are hardly soluble in water such as fragrances and refreshing agents, so that various components are incorporated into the liquid skin external preparation of the present invention. The degree of freedom increases. Furthermore, even when the liquid skin external preparation of the present invention is stored for a long time, the solubilized component does not precipitate, which is preferable.
　一方、本発明者は、成分Ａ、成分Ｄ、及び成分Ｅからなる組成物においては、成分Ｄにより成分Ａの分散性が向上した結果、静置時に成分Ａの沈降層中で成分Ａが密に充填されるためであると推定されるが、成分Ａの沈降層が強固にケーキングすることを見出した。本発明においては、上記ケーキングの問題を解消するために、成分Ｂ及び成分Ｃを添加している。これらを配合することにより、成分Ａと成分Ｂの会合体が形成することによると推定されるが、沈降層のケーキングが効果的に抑制される。なお、成分Ｃを配合せず、成分Ａと成分Ｂのみでは、会合体の形成が不十分となるためと推定されるが、ケーキング抑制効果は得られない。 On the other hand, in the composition comprising Component A, Component D, and Component E, the inventor has improved the dispersibility of Component A by Component D. It was presumed that this was due to the fact that the sedimentation layer of component A was caking strongly. In the present invention, component B and component C are added to eliminate the caking problem. By blending these, it is presumed that the aggregate of component A and component B is formed, but caking of the sedimented layer is effectively suppressed. In addition, it is presumed that the formation of the aggregates is insufficient only with Component A and Component B without adding Component C, but the caking inhibiting effect cannot be obtained.
　ここで、本発明者は、上記成分Ａ～成分Ｅを含む組成物においては、組成物を振とうした後に、粉体の沈降層と水層の他に、水層の上部に浮遊した粉体の層が生じ、３層に分離する現象が生じることを見出した。これは、詳細は不明であるが、成分Ｄによって、振とう時に生じた泡が安定化され、この泡に成分Ａや成分Ｂが付着して浮遊することによるものと推定している。このように粉体が層状に浮遊すると、液状皮膚外用剤としては外観が悪く、商品価値が低下してしまうため問題であった。 Here, in the composition containing the above-mentioned components A to E, the present inventors, after shaking the composition, in addition to the powder sedimentation layer and the water layer, the powder suspended above the water layer It was found that the phenomenon of separation into three layers occurs. Although the details are unknown, it is presumed that the foam generated when shaking is stabilized by the component D, and the component A and the component B adhere to the foam and float. When the powder floats in a layered manner in this way, the appearance as a liquid external preparation for skin is poor and the commercial value is lowered, which is a problem.
　そこで、本発明者は、さらに鋭意検討した結果、成分Ａと成分Ｂとを特定の配合比に限定した場合には、上記３層分離の問題が解消され、振とう後にも沈降層と水層に分離する外観の良好な液状皮膚外用剤が得られることを見出し、本発明を完成させた。 Therefore, as a result of further intensive studies, the present inventor has solved the above three-layer separation problem when the component A and the component B are limited to a specific blending ratio, and the settled layer and the water layer even after shaking. The present invention was completed by finding that a liquid external preparation for skin having a good appearance can be obtained.
　これにより、本発明の液状皮膚外用剤は、優れた使用感と優れた可溶化能を有しながら、なおかつ、使用時に良好な外観を呈する。 Thereby, the liquid skin external preparation of the present invention has a good appearance and a good appearance at the time of use while having an excellent feeling of use and an excellent solubilizing ability.
　以下に、本発明を実施例等に基づいてさらに詳細に説明するが、本発明はかかる実施例のみに限定されるものではない。 Hereinafter, the present invention will be described in more detail based on examples and the like, but the present invention is not limited to such examples.
実施例１～９及び比較例１～８〔液状皮膚外用剤の調製〕
　表１に記した組成からなる液状皮膚外用剤をディスパーミキサーによる攪拌混合によって調製し、下記評価に供した。実施例の液状皮膚外用剤の２５℃での粘度は全て１～２００ｍＰａ・ｓの範囲内であった。また、実施例の液状皮膚外用剤のｐＨは全て４．０～７．０の範囲内であった。 Examples 1 to 9 and Comparative Examples 1 to 8 [Preparation of liquid skin external preparation]
A liquid external preparation for skin having the composition described in Table 1 was prepared by stirring and mixing with a disper mixer and subjected to the following evaluation. The liquid skin external preparations of the examples all had viscosities at 25 ° C. in the range of 1 to 200 mPa · s. Further, the pH values of the liquid skin external preparations in the examples were all within the range of 4.0 to 7.0.
液状皮膚外用剤の評価
　各実施例及び各比較例で調製された液状皮膚外用剤の評価を次のようにして行った。 Evaluation of liquid skin external preparations The liquid skin external preparations prepared in each Example and each Comparative Example were evaluated as follows.
＜ケーキング抑止性＞
　各実施例及び各比較例で調製された液状皮膚外用剤（約１００ｍｌ）をシリンダー容器［ネスラー管、株式会社三商製、ネスラー型比色管（１００ｍｌ）、外径×長さ：φ３０×２５０（単位：ｍｍ）］に充填した。このシリンダー容器を１週間放置後、振とう幅１００ｍｍ、振とう速度１００ｍｍ／秒のスピードで振とうし、粉体の分散（沈降層を形成する粉体の分散）を目視で確認した。以下の基準に従い、ケーキング抑止性について評価した。
◎（非常に良好）：往復１０回以下の振とうにより沈降層が完全に分散する。
○（良好）：往復１１回～２０回の浸とうにより沈降層が完全に分散する。
×（不良）：往復２０回の浸とうによっても沈降層が完全に分散しない。 <Caking deterrence>
The liquid skin external preparation (about 100 ml) prepared in each example and each comparative example was placed in a cylinder container [Nessler tube, Sansho Co., Ltd., Nessler colorimetric tube (100 ml), outer diameter × length: φ30 × 250 (Unit: mm)]. The cylinder container was left to stand for 1 week, and then shaken at a shaking width of 100 mm and a shaking speed of 100 mm / second, and the dispersion of the powder (dispersion of the powder forming the sedimented layer) was visually confirmed. The caking inhibitory property was evaluated according to the following criteria.
A (very good): The sedimentation layer is completely dispersed by shaking 10 times or less.
○ (Good): The sedimentation layer is completely dispersed by soaking 11 to 20 times.
X (defect): The sedimentation layer is not completely dispersed even after 20 reciprocations.
＜外観（３層分離の有無）＞
　各実施例及び各比較例で調製された液状皮膚外用剤（約１００ｍｌ）を透明の円柱状の容器（容量１２０ｍｌ）に充填した。この容器を十分に振とうした後、放置した。放置開始から３０分後の容器の内容物の外観を目視で確認した。以下の基準に従い、外観（３層分離の有無）について評価した。
◎（非常に良好）：浮遊した粉体の層が全く見られず、３層分離が全く見られない。
○（良好）：浮遊した粉体の層がわずかに見られる。
×（不良）：浮遊した粉体の層が明らかに見られ、３層分離が明らかに見られる。 <Appearance (with or without three-layer separation)>
The liquid external preparation for skin (about 100 ml) prepared in each example and each comparative example was filled into a transparent cylindrical container (capacity 120 ml). The container was sufficiently shaken and then left standing. The appearance of the contents of the container 30 minutes after the start of standing was visually confirmed. The appearance (existence of three-layer separation) was evaluated according to the following criteria.
A (very good): No floating powder layer is observed, and no three-layer separation is observed.
○ (Good): A slight powder layer is observed.
X (defect): A layer of floating powder is clearly seen, and three-layer separation is clearly seen.
＜使用感＞
　各実施例及び各比較例で調製された液状皮膚外用剤（約１ｍｌ）を専門パネラーの顔に塗布し、以下の基準に従い、塗布後のさらさら感を評価した。なお、評価試験は、温度２３℃、相対湿度６０％の部屋内で、専門パネラー５名により実施した。
◎（非常に良好）：乾燥後に手で触れて優れたさらさら感が得られる。
○（良好）：乾燥後に手で触れてさらさら感が得られる。
×（不良）：乾燥後に手で触れてさらさら感が得られない、もしくは不快なきしみ感を感じる。 <Usage>
The liquid skin external preparation (about 1 ml) prepared in each Example and each Comparative Example was applied to the face of a specialized panelist, and the smooth feeling after application was evaluated according to the following criteria. The evaluation test was carried out by five professional panelists in a room at a temperature of 23 ° C. and a relative humidity of 60%.
A (very good): An excellent smooth feeling can be obtained by touching with a hand after drying.
○ (Good): A dry feeling can be obtained by touching with a hand after drying.
X (defect): Touching with a hand after drying, a feeling of smoothness is not obtained, or an unpleasant squeaky feeling is felt.
　下記表１に結果を示す。 The results are shown in Table 1 below.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
　各実施例、各比較例、及び下記の処方例の各原料の詳細は次の通りである。なお、表に記載の量は商品の量ではなく、各成分の量（有効成分の量）である。 Details of each raw material in each example, each comparative example, and the following prescription example are as follows. In addition, the amount described in the table is not the amount of merchandise but the amount of each component (amount of active ingredient).
ナイロン末（アイカ工業社製、商品名：ガンツパール　ＧＰＡ－５５０、ナイロン１２、平均粒径：４．０～６．０μｍ）
ベントナイト（日本有機粘土社製、商品名：ベンゲル）
ラポナイト（Ｒｏｃｋｗｏｏｄ　Ａｄｄｉｔｉｖｅｓ社製、商品名：Ｌａｐｏｎｉｔｅ　ＸＬ２１）
ＰＣＡ亜鉛（味の素社製、商品名：ＡＪＩＤＥＷ　ＺＮ－１００）
ポリオキシエチレンポリオキシプロピレンデシルテトラデシルエーテル（日本サーファクタント工業社製、商品名：ＰＥＮ－４６３０）
メントール（高砂香料工業株式会社製、商品名：メントールＪＰ　ＣＯＳ） Nylon powder (made by Aika Kogyo Co., Ltd., trade name: Ganzpearl GPA-550, nylon 12, average particle diameter: 4.0 to 6.0 μm)
Bentonite (manufactured by Nippon Organoclay Co., Ltd., trade name: Bengel)
Laponite (manufactured by Rockwood Additives, trade name: Laponite XL21)
PCA zinc (Ajinomoto Co., Ltd., trade name: AJIDEW ZN-100)
Polyoxyethylene polyoxypropylene decyl tetradecyl ether (manufactured by Nippon Surfactant Kogyo Co., Ltd., trade name: PEN-4630)
Menthol (Takasago International Corporation, trade name: Mentor JP COS)
　各実施例および比較例１の対比から、本発明の液状皮膚外用剤中、成分Ａの含有量が０．５質量％以上であると、使用感が良いことがわかる。なお、比較例１の使用感はさらさら感が得られないものであった。 From the comparison of each Example and Comparative Example 1, it can be seen that when the content of Component A is 0.5% by mass or more in the liquid skin external preparation of the present invention, the usability is good. In addition, the feeling of use of Comparative Example 1 was such that a smooth feeling was not obtained.
　各実施例および比較例２の対比から、本発明の液状皮膚外用剤中、成分Ａの含有量が５．０質量％以下であると、使用感が良いことがわかる。なお、比較例２の使用感は不快なきしみ感があるものであった。 From the comparison of each Example and Comparative Example 2, it can be seen that the usability is good when the content of Component A is 5.0% by mass or less in the liquid skin external preparation of the present invention. In addition, the usability of Comparative Example 2 was unpleasant squeaky.
　各実施例および比較例２、３、７、８の対比から、本発明の液状皮膚外用剤中、成分Ｂ及び成分Ｃをともに含むと、ケーキングが抑制されることがわかる。 From the comparison of each Example and Comparative Examples 2, 3, 7, and 8, it can be seen that when both the component B and the component C are included in the liquid skin external preparation of the present invention, caking is suppressed.
　各実施例および比較例４の対比から、成分Ａ／成分Ｂが１００以下であると、ケーキングが抑制されることがわかる。 From the comparison of each Example and Comparative Example 4, it can be seen that when component A / component B is 100 or less, caking is suppressed.
　各実施例および比較例５、６の対比から、本発明の液状皮膚外用剤中、成分Ｂの含有量が０．４質量％以下であると、３層分離を抑制できることがわかる。 From the comparison of each Example and Comparative Examples 5 and 6, it can be seen that the three-layer separation can be suppressed when the content of Component B is 0.4% by mass or less in the liquid skin external preparation of the present invention.
　さらに、以下に、本発明の液状皮膚外用剤の処方例を示す。 Furthermore, the following are examples of formulating the liquid skin external preparation of the present invention.
処方例１：清涼化粧料（化粧水）
　エタノール　　　　　　　　　　　　　　　　　　　　２５．０質量％
　グリセリン　　　　　　　　　　　　　　　　　　　　　４．０質量％
　１，３－ブチレングリコール　　　　　　　　　　　　　３．０質量％
　ポリオキシエチレンポリオキシプロピレンデシルテトラデシルエーテル
　　　　　　　　　　　　　　　　　　　　　　　　　　　０．３質量％
　キサンタンガム　　　　　　　　　　　　　　　　　　　０．０５質量％
　ＰＣＡ亜鉛　　　　　　　　　　　　　　　　　　　　　１．０質量％
　ナイロン末　　　　　　　　　　　　　　　　　　　　　２．０質量％
　ベントナイト　　　　　　　　　　　　　　　　　　　　０．２質量％
　香料　　　　　　　　　　　　　　　　　　　　　　　　０．２質量％
　メントール　　　　　　　　　　　　　　　　　　　　　０．２質量％
　ハマメリスエキス　　　　　　　　　　　　　　　　　　０．１質量％
　アロエエキス（２）　　　　　　　　　　　　　　　　　０．１質量％
　クエン酸　　　　　　　　　　　　　　　　　　　　　　０．０２質量％
　クエン酸ナトリウム　　　　　　　　　　　　　　　　　０．１質量％
　金属封鎖剤　　　　　　　　　　　　　　　　　　　　　　適量
　防腐剤　　　　　　　　　　　　　　　　　　　　　　　　適量
　精製水　　　　　　　　　　　　　　　　　　　　　　　　残部
　合計　　　　　　　　　　　　　　　　　　　　　　１００．０質量％ Formulation Example 1: Cool cosmetic (lotion)
Ethanol 25.0% by mass
Glycerin 4.0% by mass
1,3-butylene glycol 3.0% by mass
Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.3% by mass
Xanthan gum 0.05% by mass
PCA zinc 1.0% by mass
Nylon powder 2.0% by mass
Bentonite 0.2% by mass
Fragrance 0.2% by mass
Menthol 0.2% by mass
Hamamelis extract 0.1% by mass
Aloe extract (2) 0.1% by mass
Citric acid 0.02% by mass
Sodium citrate 0.1% by mass
Metal sequestering agent Appropriate amount Preservative Appropriate amount Purified water balance Total 100.0% by mass
処方例２：ニキビ用（殺菌用）化粧料（化粧水）
　エタノール　　　　　　　　　　　　　　　　　　　　１５．０質量％
　グリセリン　　　　　　　　　　　　　　　　　　　　　４．０質量％
　１，３－ブチレングリコール　　　　　　　　　　　　　３．０質量％
　ポリオキシエチレンポリオキシプロピレンデシルテトラデシルエーテル
　　　　　　　　　　　　　　　　　　　　　　　　　　　０．３質量％
　ＰＣＡ亜鉛　　　　　　　　　　　　　　　　　　　　　１．０質量％
　ナイロン末　　　　　　　　　　　　　　　　　　　　　２．０質量％
　ベントナイト　　　　　　　　　　　　　　　　　　　　０．２質量％
　香料　　　　　　　　　　　　　　　　　　　　　　　　０．２質量％
　メントール　　　　　　　　　　　　　　　　　　　　　０．０５質量％
　イソプロピルメチルフェノール　　　　　　　　　　　　０．１質量％
　サリチル酸　　　　　　　　　　　　　　　　　　　　　０．１質量％
　グリチルリチン酸ジカリウム　　　　　　　　　　　　　０．１質量％
　クエン酸　　　　　　　　　　　　　　　　　　　　　　０．０２質量％
　クエン酸ナトリウム　　　　　　　　　　　　　　　　　０．１質量％
　金属封鎖剤　　　　　　　　　　　　　　　　　　　　　　適量
　防腐剤　　　　　　　　　　　　　　　　　　　　　　　　適量
　精製水　　　　　　　　　　　　　　　　　　　　　　　　残部
　合計　　　　　　　　　　　　　　　　　　　　　　１００．０質量％ Formulation Example 2: Acne (for sterilization) cosmetic (skin lotion)
Ethanol 15.0% by mass
Glycerin 4.0% by mass
1,3-butylene glycol 3.0% by mass
Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.3% by mass
PCA zinc 1.0% by mass
Nylon powder 2.0% by mass
Bentonite 0.2% by mass
Fragrance 0.2% by mass
Menthol 0.05% by mass
Isopropyl methylphenol 0.1% by mass
Salicylic acid 0.1% by mass
Dipotassium glycyrrhizinate 0.1% by mass
Citric acid 0.02% by mass
Sodium citrate 0.1% by mass
Metal sequestering agent Appropriate amount Preservative Appropriate amount Purified water balance Total 100.0% by mass
処方例３：美白用化粧料（化粧水）
　エタノール　　　　　　　　　　　　　　　　　　　　１０．０質量％
　グリセリン　　　　　　　　　　　　　　　　　　　　　４．０質量％
　１，３－ブチレングリコール　　　　　　　　　　　　　３．０質量％
　ポリオキシエチレンポリオキシプロピレンデシルテトラデシルエーテル
　　　　　　　　　　　　　　　　　　　　　　　　　　　０．５質量％
　キサンタンガム　　　　　　　　　　　　　　　　　　　０．０５質量％
　塩化ナトリウム　　　　　　　　　　　　　　　　　　　０．２質量％
　ナイロン末　　　　　　　　　　　　　　　　　　　　　２．０質量％
　ベントナイト　　　　　　　　　　　　　　　　　　　　０．２質量％
　無水ケイ酸　　　　　　　　　　　　　　　　　　　　　０．８質量％
　香料　　　　　　　　　　　　　　　　　　　　　　　　０．２質量％
　Ｌ－アスコルビン酸２－グルコシド　　　　　　　　　　２．０質量％
　グリチルリチン酸ジカリウム　　　　　　　　　　　　　０．１質量％
　クエン酸　　　　　　　　　　　　　　　　　　　　　　０．０２質量％
　クエン酸ナトリウム　　　　　　　　　　　　　　　　　０．１質量％
　金属封鎖剤　　　　　　　　　　　　　　　　　　　　　　適量
　防腐剤　　　　　　　　　　　　　　　　　　　　　　　　適量
　精製水　　　　　　　　　　　　　　　　　　　　　　　　残部
　合計　　　　　　　　　　　　　　　　　　　　　　１００．０質量％ Formulation Example 3: Whitening Cosmetic (Lotion)
Ethanol 10.0% by mass
Glycerin 4.0% by mass
1,3-butylene glycol 3.0% by mass
Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.5% by mass
Xanthan gum 0.05% by mass
Sodium chloride 0.2% by mass
Nylon powder 2.0% by mass
Bentonite 0.2% by mass
Silica anhydride 0.8% by mass
Fragrance 0.2% by mass
L-ascorbic acid 2-glucoside 2.0% by mass
Dipotassium glycyrrhizinate 0.1% by mass
Citric acid 0.02% by mass
Sodium citrate 0.1% by mass
Metal sequestering agent Appropriate amount Preservative Appropriate amount Purified water balance Total 100.0% by mass
処方例４：美白用化粧料（化粧水）
　エタノール　　　　　　　　　　　　　　　　　　　　１０．０質量％
　グリセリン　　　　　　　　　　　　　　　　　　　　　４．０質量％
　１，３－ブチレングリコール　　　　　　　　　　　　　３．０質量％
　ポリオキシエチレンポリオキシプロピレンデシルテトラデシルエーテル
　　　　　　　　　　　　　　　　　　　　　　　　　　　０．５質量％
　キサンタンガム　　　　　　　　　　　　　　　　　　　０．０５質量％
　塩化ナトリウム　　　　　　　　　　　　　　　　　　　０．２質量％
　ナイロン末　　　　　　　　　　　　　　　　　　　　　２．０質量％
　ベントナイト　　　　　　　　　　　　　　　　　　　　０．２質量％
　無水ケイ酸　　　　　　　　　　　　　　　　　　　　　０．８質量％
　香料　　　　　　　　　　　　　　　　　　　　　　　　０．２質量％
　トラネキサム酸　　　　　　　　　　　　　　　　　　　２．０質量％
　グリチルリチン酸ジカリウム　　　　　　　　　　　　　０．１質量％
　クエン酸　　　　　　　　　　　　　　　　　　　　　　０．０２質量％
　クエン酸ナトリウム　　　　　　　　　　　　　　　　　０．１質量％
　金属封鎖剤　　　　　　　　　　　　　　　　　　　　　　適量
　防腐剤　　　　　　　　　　　　　　　　　　　　　　　　適量
　精製水　　　　　　　　　　　　　　　　　　　　　　　　残部
　合計　　　　　　　　　　　　　　　　　　　　　　１００．０質量％ Formulation Example 4: Whitening Cosmetic (Lotion)
Ethanol 10.0% by mass
Glycerin 4.0% by mass
1,3-butylene glycol 3.0% by mass
Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.5% by mass
Xanthan gum 0.05% by mass
Sodium chloride 0.2% by mass
Nylon powder 2.0% by mass
Bentonite 0.2% by mass
Silica anhydride 0.8% by mass
Fragrance 0.2% by mass
Tranexamic acid 2.0% by mass
Dipotassium glycyrrhizinate 0.1% by mass
Citric acid 0.02% by mass
Sodium citrate 0.1% by mass
Metal sequestering agent Appropriate amount Preservative Appropriate amount Purified water balance Total 100.0% by mass
処方例５：体用清涼化粧料（ミスト）
　エタノール　　　　　　　　　　　　　　　　　　　　４０．０質量％
　１，３－ブチレングリコール　　　　　　　　　　　　　３．０質量％
　ポリオキシエチレンポリオキシプロピレンデシルテトラデシルエーテル
　　　　　　　　　　　　　　　　　　　　　　　　　　　０．２質量％
　パラフェノールスルホン酸亜鉛　　　　　　　　　　　　０．３質量％
　ナイロン末　　　　　　　　　　　　　　　　　　　　　２．０質量％
　ベントナイト　　　　　　　　　　　　　　　　　　　　０．２質量％
　無水ケイ酸　　　　　　　　　　　　　　　　　　　　　２．０質量％
　架橋ポリスチレン　　　　　　　　　　　　　　　　　　１．０質量％
　香料　　　　　　　　　　　　　　　　　　　　　　　　０．２質量％
　イソプロピルメチルフェノール　　　　　　　　　　　　０．１質量％
　メントール　　　　　　　　　　　　　　　　　　　　　２．０質量％
　メンチルグリセリルエーテル　　　　　　　　　　　　　０．３質量％
　カンファ　　　　　　　　　　　　　　　　　　　　　　０．１質量％
　１，８－シネオール　　　　　　　　　　　　　　　　　０．１質量％
　ボルネオール　　　　　　　　　　　　　　　　　　　　０．１質量％
　カルボキシビニルポリマー　　　　　　　　　　　　　　０．０１質量％
　水酸化カリウム　　　　　　　　　　　　　　　　　　　　適量
　金属封鎖剤　　　　　　　　　　　　　　　　　　　　　　適量
　精製水　　　　　　　　　　　　　　　　　　　　　　　　残部
　合計　　　　　　　　　　　　　　　　　　　　　　１００．０質量％
　上記組成物を、非エアゾール型のスプレー容器に充填してミスト化粧料とする。 Formulation Example 5: Body Cool Cosmetic (Mist)
Ethanol 40.0% by mass
1,3-butylene glycol 3.0% by mass
Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.2% by mass
Zinc paraphenolsulfonate 0.3% by mass
Nylon powder 2.0% by mass
Bentonite 0.2% by mass
Silica anhydride 2.0% by mass
Cross-linked polystyrene 1.0% by mass
Fragrance 0.2% by mass
Isopropyl methylphenol 0.1% by mass
Menthol 2.0% by mass
Menthyl glyceryl ether 0.3% by mass
Kanfa 0.1% by mass
1,8-cineole 0.1% by mass
Borneol 0.1% by mass
Carboxyvinyl polymer 0.01% by mass
Potassium hydroxide appropriate amount Metal sequestering agent appropriate amount Purified water balance 100.0% by mass
The composition is filled in a non-aerosol type spray container to obtain a mist cosmetic.
　本発明の液状皮膚外用剤は、例えば、化粧水として使用することができる。 The liquid skin external preparation of the present invention can be used, for example, as a lotion.

Claims (3)

  1. 　成分Ａ：ナイロン末、成分Ｂ：ベントナイト及び／又はラポナイト、成分Ｃ：有機塩及び／又は無機塩、成分Ｄ：ノニオン界面活性剤、並びに成分Ｅ：水を含み、
    前記成分Ａの含有量が０．５～５．０質量％であり、
    前記成分Ｂの含有量が０．４質量％以下であり、
    前記成分Ｃの含有量が０．１～３．０質量％であり、
    前記成分Ｂの含有量に対する前記成分Ａの含有量の質量比[（前記成分Ａの含有量）／（前記成分Ｂの含有量）]が１００以下である、液状皮膚外用剤。     Component A: nylon powder, component B: bentonite and / or laponite, component C: organic salt and / or inorganic salt, component D: nonionic surfactant, and component E: water,
    The content of the component A is 0.5 to 5.0% by mass,
    The content of component B is 0.4% by mass or less,
    The content of component C is 0.1 to 3.0% by mass;
    Liquid skin external preparation whose mass ratio [(content of said component A) / (content of said component B)] of content of said component A with respect to content of said component B is 100 or less.
  2. 　前記成分Ｄの含有量が０．０１～５．０質量％である、請求項１記載の液状皮膚外用剤。 The liquid skin external preparation according to claim 1, wherein the content of the component D is 0.01 to 5.0 mass%.
  3. 　化粧水である、請求項１または２記載の液状皮膚外用剤。
          The liquid skin external preparation of Claim 1 or 2 which is a skin lotion.
PCT/JP2015/081871 2014-11-27 2015-11-12 Liquid topical preparation for skin WO2016084615A1 (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020004192A1 (en) * 2018-06-28 2020-01-02 小林製薬株式会社 Aqueous composition containing isopropyl methylphenol
JP2020147537A (en) * 2019-03-14 2020-09-17 株式会社マンダム Skin external preparation composition

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6862069B2 (en) * 2017-05-30 2021-04-21 株式会社マンダム Foam skin cleanser

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001335413A (en) * 2000-05-26 2001-12-04 Lion Corp Cosmetic
JP2004067628A (en) * 2002-08-08 2004-03-04 Shiseido Co Ltd Water-in-oil type emulsified composition
JP2006335740A (en) * 2005-06-06 2006-12-14 Dai Ichi Kogyo Seiyaku Co Ltd Conditioning composition and hair cosmetic
JP2008208089A (en) * 2007-02-27 2008-09-11 Kumano Yushi Kk Skin cleaner
JP2011051923A (en) * 2009-09-01 2011-03-17 Mandom Corp Two-layer cosmetic
JP2014080397A (en) * 2012-10-17 2014-05-08 Rocket Soap Co Ltd Oil-in-water type skin care preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003113033A (en) * 2001-09-28 2003-04-18 Kose Corp Water-in-oil type cosmetic
JP2004262887A (en) 2003-03-04 2004-09-24 Kanebo Ltd Two-layer cosmetic
JP4073389B2 (en) * 2003-10-31 2008-04-09 株式会社資生堂 Water-in-oil emulsion composition
WO2010146630A1 (en) * 2009-06-19 2010-12-23 株式会社資生堂 Cosmetic
JP2013103892A (en) * 2011-11-11 2013-05-30 Shiseido Co Ltd Lotion composition and sheet-like cosmetic using the same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001335413A (en) * 2000-05-26 2001-12-04 Lion Corp Cosmetic
JP2004067628A (en) * 2002-08-08 2004-03-04 Shiseido Co Ltd Water-in-oil type emulsified composition
JP2006335740A (en) * 2005-06-06 2006-12-14 Dai Ichi Kogyo Seiyaku Co Ltd Conditioning composition and hair cosmetic
JP2008208089A (en) * 2007-02-27 2008-09-11 Kumano Yushi Kk Skin cleaner
JP2011051923A (en) * 2009-09-01 2011-03-17 Mandom Corp Two-layer cosmetic
JP2014080397A (en) * 2012-10-17 2014-05-08 Rocket Soap Co Ltd Oil-in-water type skin care preparation

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020004192A1 (en) * 2018-06-28 2020-01-02 小林製薬株式会社 Aqueous composition containing isopropyl methylphenol
JP2020002058A (en) * 2018-06-28 2020-01-09 小林製薬株式会社 Aqueous composition comprising isopropyl methylphenol
JP7258478B2 (en) 2018-06-28 2023-04-17 小林製薬株式会社 Aqueous composition containing isopropylmethylphenol
JP2020147537A (en) * 2019-03-14 2020-09-17 株式会社マンダム Skin external preparation composition
JP7261046B2 (en) 2019-03-14 2023-04-19 株式会社マンダム sheet cosmetics

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