TW201345558A - External preparation for skin - Google Patents

Abstract

The present invention is an external preparation for the skin, which is characterized by containing (A) silver-supporting antibacterial tricalcium phosphate and (B) a polypropylene glycol having a number average molecular weight of 700-4,000, a copolymer of a polypropylene glycol having a number average molecular weight of 700-4,000 and a polybutylene glycol, or a derivative of a polypropylene glycol having a number average molecular weight of 700-4,000. The purpose of the present invention is to provide an external preparation for the skin, which contains a silver-supporting antibacterial tricalcium phosphate powder and is prevented from giving a powdery look caused by the silver-supporting antibacterial tricalcium phosphate powder.

Description

Skin external preparation

The present invention relates to a skin external preparation. More specifically, the present invention relates to a skin external preparation prepared by mixing a tricalcium phosphate powder carrying silver and reducing or preventing the whitening caused by the tricalcium phosphate powder carrying silver.

The antibacterial tricalcium phosphate powder is formulated as a preservative or deodorant to an external preparation for skin such as a cosmetic or a quasi-drug.

For example, Patent Document 1 discloses a deodorant formulated with an antibacterial tricalcium phosphate. The object of Patent Document 1 is to provide a deodorant which removes malodors and efficiently kills bacteria which decompose the living secretions to produce malodor, and which is harmless to the living body. However, Patent Document 1 does not describe or whiten the whitening which occurs when the antibacterial tricalcium phosphate is formulated.

Patent Document 1: Japanese Patent Laid-Open No. Hei 8-126690

On the other hand, the present inventors have found that a skin external preparation containing antibacterial tricalcium phosphate loaded with silver causes a problem of whitening from the antibacterial tricalcium phosphate carrying silver. In other words, when a skin external preparation containing antibacterial tricalcium phosphate loaded with silver is used, there is a problem that whiteness is noticeable in the body part to be coated.

In view of the above, the inventors of the present invention have in order to prevent the antibacterial phosphoric acid supported on silver. The tri-calcium powder caused whitening and painstaking research. As a result, it was found that if the skin external preparation containing silver antibacterial tricalcium phosphate powder was formulated, the polypropylene glycol having a number average molecular weight of 700 to 4000 was prepared, and the number average molecular weight was A copolymer of polypropylene glycol and polytetramethylene glycol of 700 to 4000 or a derivative of polypropylene glycol having a number average molecular weight of 700 to 4000 can be used to obtain white color after coating, which can reduce or prevent whitening of the skin. Agent to complete the present invention.

The object of the present invention is to provide an antibacterial phosphoric acid loaded with silver A tricalcium powder which reduces or prevents the skin external preparation caused by the antibacterial tricalcium phosphate powder loaded with silver.

That is, the present invention provides a skin external preparation comprising: (A) an antibacterial tricalcium phosphate loaded with silver, and (B) a polypropylene glycol having a number average molecular weight of 700 to 4000, and a number average molecular weight of 700 to 4000. Any of a copolymer of propylene glycol and polytetramethylene glycol or a derivative of polypropylene glycol having a number average molecular weight of 700 to 4,000.

Further, the present invention provides the above-mentioned external preparation for skin, wherein the (B) derivative of polypropylene glycol having a number average molecular weight of 700 to 4000 is a polyoxypropylene glyceryl ether having a number average molecular weight of 700 to 4000, and a number average molecular weight of 700 to 4000. Any of polyoxypropylene sorbitol and polyoxypropylene butyl ether having a number average molecular weight of 700 to 4,000.

Furthermore, the present invention provides the skin external preparation containing 30% by mass or more of ethanol based on the total amount of the external preparation for skin.

Moreover, the present invention provides the above-mentioned skin external preparation which is a liquid cosmetic and which is a deodorant cosmetic which can be filled in a roll-on container.

Further, the present invention provides the above skin external preparation which is a liquid cosmetic and which is A mist-like deodorant cosmetic that can be filled in an aerosol or dispenser container.

Moreover, the present invention provides the above-mentioned skin external preparation which is a liquid cosmetic and which is a sheet-like deodorant cosmetic impregnated into a sheet.

The effect of the present invention is to reduce or prevent whitening caused by the antibacterial tricalcium phosphate powder carrying silver in the skin external preparation containing the antibacterial tricalcium phosphate powder loaded with silver.

Hereinafter, the present invention will be described in detail.

<(A) Antibacterial tricalcium phosphate loaded with silver>

In the present invention, as the component (A), the antibacterial tricalcium phosphate supported on silver may be a powder of tricalcium phosphate which retains antibacterial silver in tricalcium phosphate.

A commercially available product (Apacider C: Sangi Co., Ltd.) can be used in the present invention.

<(A) Formulation amount of antibacterial tricalcium phosphate loaded with silver>

The amount of the antibacterial tricalcium phosphate supported on the silver is 0.1 to 20% by mass, preferably 1 to 10% by mass, and more preferably 2 to 7% by mass based on the total amount of the external preparation for skin. The appropriate amount can be appropriately determined and formulated according to the form of the product.

"(B) Polypropylene glycol having a number average molecular weight of 700 to 4000, a copolymer of polypropylene glycol and polytetramethylene glycol having a number average molecular weight of 700 to 4000, or a derivative of polypropylene glycol having a number average molecular weight of 700 to 4000"

In the present invention, the component (B) formulated to reduce or prevent whitening is as follows. One (2) to (3) or two or more of the components (B) are blended.

(1) Polypropylene glycol having a number average molecular weight of 700 to 4000

(2) Copolymer of polypropylene glycol and polytetramethylene glycol having a number average molecular weight of 700 to 4000

(3) a derivative of polypropylene glycol having a number average molecular weight of 700 to 4000 (specifically, a polyoxypropylene glyceryl ether having a number average molecular weight of 700 to 4000, a polyoxypropylene sorbitol having a number average molecular weight of 700 to 4000, a polyoxypropylene butyl ether having a number average molecular weight of 700 to 4000, etc.)

In the present invention, the number average molecular weight can be determined by the method described in 942 pages of the second edition of the Cosmetic Raw Materials Standards I (1984 Pharmaceutical Daily).

Commercially available products can be used as the components of the above (1) to (3).

(1) As the polypropylene glycol having a number average molecular weight of 700 to 4,000, Newpol PP-1000 (Sanyo Chemical Industry Co., Ltd.) having a number average molecular weight of 1,000 and Newpol PP-2000 having a number average molecular weight of 2000 can be preferably used. Sanyo Chemical Industry Co., Ltd.), Newpol PP-4000 (Sanyo Chemical Industry Co., Ltd.) with a number average molecular weight of 4,000.

(2) As a copolymer of polypropylene glycol and polytetramethylene glycol having a number average molecular weight of 700 to 4000, PBG (polypropylene glycol)/PPG (polybutylene glycol)-9/1 copolymer having a number average molecular weight of 700 can be preferably used. (a copolymer of polybutanediol and polypropylene glycol of 9:1. UNIOL PB-700, Nippon Oil & Fat Co., Ltd.) and the like.

(3) As the derivative of polypropylene glycol having a number average molecular weight of 700 to 4,000, polyoxypropylene glyceryl ether, polyoxypropylene sorbitol, polyoxypropylene butyl ether or the like can be preferably used.

As the polyoxypropylene glyceryl ether, Newpol GP-1000 (Sanyo Chemical Industry Co., Ltd.) having a number average molecular weight of 1,000, Newpol GP-4000 (Sanyo Chemical Industry Co., Ltd.) having a number average molecular weight of 4,000 or the like can be preferably used. .

Further, as the polyoxypropylene sorbitol, a number average molecular weight of 700 is preferably used. Newpol SP-750 (Sanyo Chemical Industry Co., Ltd.) and so on.

Further, as the polyoxypropylene butyl ether, Newpol LB-285 (Sanyo Chemical Industry Co., Ltd.) having a number average molecular weight of 1,200 and Newpol LB-625 (Sanyo Chemical Industry Co., Ltd.) having an average molecular weight of 1,870 can be preferably used. Wait.

The components (1) to (3) are usually formulated as a moisturizing agent in the external preparation for skin, but in the present invention, the whitening effect caused by reducing or preventing the antibacterial tricalcium phosphate powder loaded with silver is exhibited. It is an essential component of the effect and is formulated as a whitening prevention agent.

<(B) Polypropylene glycol having a number average molecular weight of 700 to 4000, a copolymer of polypropylene glycol and polytetramethylene glycol having a number average molecular weight of 700 to 4000, or a derivative of a polypropylene glycol derivative having a number average molecular weight of 700 to 4000 >

The amount of the component (B) to be added is 0.1 to 20% by mass, preferably 1 to 20% by mass, and more preferably 5 to 20% by mass based on the total amount of the external preparation for skin. The blending amount of the component (B) can be appropriately determined according to the form of the product and blended in an appropriate amount.

In addition to the above-mentioned essential components, other ingredients such as a powder component, a liquid fat, and a solid which are formulated in a skin external preparation such as a general cosmetic or a quasi-drug can be used in addition to the above-mentioned essential components. Oils, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, ester oils, polyoxygenated oils, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, humectants, coating agents, UV absorption Agent, metal ion chelating agent, lower alcohol, polyol, sugar, amino acid, organic amine, polymer emulsion, pH adjuster, skin nutrient, vitamin, antioxidant, antioxidant, fragrance, water, etc. It needs to be properly formulated and manufactured according to the target dosage form by a common method.

Further, the dosage form of the present invention is not limited, and a liquid external preparation for skin which is obtained by dispersing an antibacterial tricalcium phosphate powder carrying silver is preferable.

In particular, from the viewpoint of improving the solubility of the component B or imparting a cooling sensation or a speed of drying, it is preferred to blend at least 30% by mass or more with respect to the total amount of the external preparation for skin, preferably A liquid skin external preparation of 30% by mass to 95% by mass is formulated.

The form of the product for external use of the skin of the present invention is not particularly limited. For example, preferably A liquid cosmetic (1) in which a silver-loaded antibacterial tricalcium phosphate powder is dispersed is filled into a deodorant cosmetic in a roll-on container, and (2) is filled into an aerosol or dispenser container. The misty and deodorant cosmetic in the middle, and (3) the form of a product such as a sheet-like deodorant cosmetic which is impregnated into a sheet such as a non-woven fabric, and the like can be produced by a usual method.

In addition to the above-mentioned product form, a deodorant cosmetic such as a powder type, a powder type, or a paste type can be produced as a skin external preparation of the present invention by a usual method.

Example

Next, the present invention will be further specifically described by way of examples. The invention is not limited thereto. The blending amount is the mass % relative to the total amount unless otherwise specified.

A liquid cosmetic prepared by dispersing silver-containing antibacterial tricalcium phosphate was prepared by a usual method in the formulation shown in "Table 1", and the effect of the present invention, that is, the coated pan, was confirmed by the following evaluation method. White.

"Evaluation of Whitening Prevention"

10 μL of the skin external preparations of "Table 1" to "Table 3" were applied to a range of 1.5 cm × 1.5 cm on black artificial skin using a micropipette. The whitening after two hours was visually confirmed, and the evaluation was performed using the following criteria.

<Evaluation criteria>

◎: No whitening was seen at all.

○: A slight whitening was observed, but the whitening was greatly reduced as compared with Comparative Example 1, and was within the allowable range.

×: Clearly see whitening.

"Reduce the whitening, prevent the effect"

Commercially available products which are used as various humectants other than the B component and the B component used above are as follows.

According to the results of the above-mentioned "Table 2" and "Table 3", it is understood that the examples of the present invention have an effect of excellent whitening prevention effect.

On the other hand, a comparative example in which a humectant such as polypropylene glycol 200, polypropylene glycol 400 or POE-POP dimethyl ether was blended instead of the component (B) of the present invention did not have a whitening prevention effect.

Hereinafter, a formulation example of the external preparation for skin of the present invention will be listed. Its whitening is reduced and the prevention effect is excellent.

"Recipe Example 1: Cosmetics for Roll-on Containers (Liquid Cosmetics)"

"Recipe 2: Cosmetics suitable for roll-on containers (liquid cosmetics)"

"Recipe 3: A misty and deodorant cosmetic that can be filled in an aerosol or dispenser container"

"Formulation Example 4: A sheet-like deodorant cosmetic that can be immersed in a sheet"

[Industrial availability]

According to the present invention, it is possible to provide an external preparation for skin which is formulated with an antibacterial tricalcium phosphate powder carrying silver and which reduces or prevents whitening caused by the antibacterial tricalcium phosphate powder carrying silver.

Claims (6)

An external preparation for skin comprising: (A) an antibacterial tricalcium phosphate loaded with silver, and (B) a polypropylene glycol having a number average molecular weight of 700 to 4000, a polypropylene glycol having a number average molecular weight of 700 to 4000, and polybutane Any one of a copolymer of an alcohol or a derivative of a polypropylene glycol having a number average molecular weight of 700 to 4,000. The skin external preparation according to Item 1 of the patent application, wherein the (B) derivative of polypropylene glycol having a number average molecular weight of 700 to 4000 is a polyoxypropylene glyceryl ether having a number average molecular weight of 700 to 4000, and a number average molecular weight of 700. Any of polyoxypropylene sorbitol of ~4000 and polyoxypropylene butyl ether of a number average molecular weight of 700-4000. The skin external preparation according to Item 1 or Item 2 of the patent application contains 30% by mass or more of ethanol based on the total amount of the external preparation for skin. The skin external preparation according to any one of claims 1 to 3, which is a liquid cosmetic and is a deodorant cosmetic which can be filled in a roll-on type container. The skin external preparation according to any one of claims 1 to 3, which is a liquid cosmetic and is a mist-like deodorant cosmetic which can be filled in an aerosol type or dispenser type container. The skin external preparation according to any one of claims 1 to 3, which is a liquid cosmetic and is a sheet-like deodorant cosmetic impregnated in a sheet.