WO2015170881A1 - Composition d'aliment fonctionnel diététique améliorant la circulation sanguine ou augmentant l'activité capillaire - Google Patents

Composition d'aliment fonctionnel diététique améliorant la circulation sanguine ou augmentant l'activité capillaire Download PDF

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Publication number
WO2015170881A1
WO2015170881A1 PCT/KR2015/004533 KR2015004533W WO2015170881A1 WO 2015170881 A1 WO2015170881 A1 WO 2015170881A1 KR 2015004533 W KR2015004533 W KR 2015004533W WO 2015170881 A1 WO2015170881 A1 WO 2015170881A1
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Prior art keywords
parts
weight
food composition
blood circulation
extract powder
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PCT/KR2015/004533
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English (en)
Korean (ko)
Inventor
남린
김승배
박정순
황호성
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주식회사 웰솔루션
남린
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Application filed by 주식회사 웰솔루션, 남린 filed Critical 주식회사 웰솔루션
Publication of WO2015170881A1 publication Critical patent/WO2015170881A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof

Definitions

  • the present invention relates to a health functional food composition for blood circulation improvement or capillary activity increase.
  • Blood circulation refers to the movement of blood through blood vessels to parts of the body.
  • blood circulation is regulated by a variety of factors, including physical factors such as hematocrit, viscosity, and shear stress caused by blood, as well as changes in blood lipid composition and blood cells (platelets). This is the main factor.
  • Blood circulation improvers prevent the aging of cells and organs and promote cell growth and regeneration by restoring the inhibited blood flow to a normal state, resulting in stiff shoulders and neck, limb tingling, cold hands and feet, and lower body edema caused by peripheral blood circulation disorders. Reduces hair loss symptoms caused by disorders of the scalp blood circulation.
  • Patent Document 1 Republic of Korea Patent No. 10-1086504 (name of the invention: composition for skin application having blood circulation improvement and vasodilation function), "including the step of applying the composition to the skin, improve blood circulation and blood vessels How to expand it.
  • Patent Document 2 Republic of Korea Patent No. 10-1259499 (name of the invention: blood circulation improving composition comprising a ginseng fat-soluble component) relates to "Ginseng fat-soluble component that can be utilized as a pharmaceutical composition or food composition for improving blood circulation" Is described.
  • An object of the present invention is to develop and provide a food composition for blood circulation improvement and capillary activity increase.
  • the present invention is bromelline (pineapple extract powder) 31.8 parts by weight, vitamin C 71.43 parts by weight, vitamin B 12 7.143 parts by weight, nattokinase powder 4.287 parts by weight, ginkgo leaf extract powder 8.1 5 parts by weight, taurine 58.5 parts by weight, chicory root extract powder 27 parts by weight, grape seed extract powder 8.585 parts by weight, Oza extract powder 8.55 parts by weight, L-proline 8.22 parts by weight, turmeric extract powder 6.6 Parts by weight, coenzyme Q10 6.357 parts by weight, octacosanol powder 4.26 parts by weight, curry leaf extract powder 1.32 parts by weight, selenium-containing dry yeast 0.9 parts by weight, chromium-containing dry yeast 0.49 parts, vitamin B 2 0.021 It provides a food composition for improving blood circulation or capillary activity, characterized in that the mixture by weight, 35.922 parts by weight of crystalline cellulose, 2.7 parts by weight of magnesium
  • the bromelain pineapple extract powder
  • GDU means "gelatin digestion unit”
  • the vitamin C is used as a coenzyme of various enzymatic reactions in vivo and is involved in the synthesis of collagen, which is a major protein constituting connective tissues such as skin skeleton, blood vessels and cartilage. It also plays a role in preventing the onset of lipid peroxidation, such as low density lipoprotein (LDL).
  • LDL low density lipoprotein
  • the vitamin B 12 preferably contains 0.05 to 0.3% by weight of vitamin B 12 as an indicator component.
  • vitamin B 12 is converted into methylcobalamin or 5-deoxyadenosylcobalamin in the body to serve as a coenzyme to move a single carbon unit.
  • the nattokinase powder preferably contains 40 to 60% by weight of Bacillus subtlis natto culture powder and 40 to 60% by weight of dextrin.
  • Natokinase powder preferably has fibrinolytic enzyme activity of 17,000-28,000 FU / g (FU stands for "Fibrin Unit"), and when it satisfies the enzyme activity range, it interferes with the coagulation of blood. , Blood flows smoothly.
  • the NATO culture powder is a natural raw material containing enzyme produced by the bacteria derived from Cheonggukjang, contains a large amount of high-quality protein and glutamic acid, etc., and can help to improve blood circulation from the KFDA. It is a recognized raw material.
  • the ginkgo leaf extract powder preferably contains 24 to 30% by weight of flavonol glycosides.
  • Ginkgo biloba extract powder is composed of flavonoid-based compounds such as kaempherol, quercetin and isoramretin, and if it meets the above range, it works by reducing blood clots and expanding blood vessels in the bloodstream. Help improve
  • the taurine acts to suppress the sympathetic nerve of the brain to stabilize blood pressure, increase the output of the heart, to prevent arrhythmia and heart failure.
  • the chicory root extract powder acts to lower triglycerides and cholesterol.
  • the grape seed extract powder functions as an antioxidant, protecting the body from free radicals.
  • the Oja extract powder is prepared by mixing the extract of Schisandra chinensis, wolfberry, casualty, earthenware, bokbunja in the same ratio, and restores vascular system function and blood pressure control.
  • the L-proline (L-Proline) to help the collagen (collagen) production make the skin more healthy, promote the regeneration of cartilage and strengthen the joints, myocardium do.
  • the turmeric extract powder lowers the blood cholesterol level of the human body, improves fat digestion function to prevent atherosclerosis, and lowers the blood sugar of the human body so that blood vessels are not blocked. do.
  • the coenzyme Q10 is, for example, Agrobacterium tumefaciens ( Agrobacterium tumefaciens ), Paracoccus denitrificans ( Pseudomonas aeruginosa ), Pseudomonas aeruginosa
  • Agrobacterium tumefaciens Agrobacterium tumefaciens
  • Paracoccus denitrificans Pseudomonas aeruginosa
  • Pseudomonas aeruginosa Pseudomonas aeruginosa
  • the culture product of may be extracted with hexane, acetone, isopropyl alcohol, ethyl acetate and concentrated or purified to make it suitable for edible use.
  • the octacosanol powder to increase the LDL receptor required when the decomposition of low density lipoprotein (LDL) to promote the decomposition of LDL.
  • LDL low density lipoprotein
  • mevalonate which is involved in the synthesis of cholesterol, the action of cholesterol synthase, and increases the activity of cholesterol degrading enzymes to lower total cholesterol levels.
  • the curry leaf extract powder has an antioxidant component, and serves to protect the digestive tract and support the absorption and activity of iron.
  • the selenium-containing dry yeast has an antioxidant effect of inhibiting cell damage.
  • the chromium-containing dry yeast has an antioxidant action to inhibit cell damage.
  • the vitamin B 2 is a coenzyme involved in various enzymatic reactions, and particularly plays an important role in caloric metabolism.
  • the extraction powder of the material can be used by drying the extracted by the method of hot water extraction commonly used in the art.
  • the material may be prepared by hot water extraction to obtain an extract, and then freeze drying or spray drying.
  • composition of the present invention can be ingested by itself, but may be used in addition to food.
  • examples of the food to be added include meat, grains, caffeine drinks, general beverages, chocolate, dairy products, breads, snacks, confectionery, pizza, jelly, noodles, gums, ice creams, vitamin complexes, but are not necessarily limited thereto.
  • composition of the present invention facilitates blood circulation, increases capillary activity, and exerts an effect on suppressing blood coagulation and improving blood circulation.
  • metabolism is active through this, it is effective in preventing dementia, stroke and heart attack.
  • 1 is a diagram showing an example of abnormal blood vessel shape.
  • FIG. 2 is a diagram showing the shape and number of normal blood vessels.
  • Figure 3 is a photograph before, after, and after the increase in the activity of the capillary blood vessels when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.
  • Figure 4 is a photograph before, after, and after the increase in activity of adult capillaries when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.
  • Example 1 For use in Example 1, a raw material conforming to the standards such as health functional foods, foods, food additives, etc. was purchased. Using electronic balance, bromelline (pineapple extract powder) 31.8 kg, vitamin C 71.43 kg, vitamin B 12 7.143 kg, nattokinase powder 4.287 kg, ginkgo leaf extract powder 8.1 kg, taurine 58.5 kg, Chicory root extract powder 27 kg, grape seed extract powder 8.585 kg, quince extract powder 8.55 kg, L-Proline 8.22 kg, turmeric extract powder 6.6 kg, coenzyme Q10 6.357 kg, octacosanol powder ) 4.26 kg, curry leaf extract powder 1.32 kg, selenium dry yeast 0.9 kg, chromium-containing dry yeast 0.49 kg, vitamin B 2 0.021 kg, crystalline cellulose 35.922 kg, magnesium stearate and 4.5 kg silicon dioxide It was then compressed in a tableting machine to prepare a mixed composition for blood circulation improvement or capillary activity increase.
  • Example 1 the mixed composition prepared in Example 1 was mixed in the mixing ratio described in Example 1 and tableted in a tableting machine. Thereafter, a tablet containing 50,000 ml of ethanol, 2.096 kg of hydroxypropylmethylcellulose, and 0.419 kg of glycerin fatty acid ester was coated on a tablet, and then screened to prepare a tablet-type health functional food composition having a size of 1050 mg.
  • Example 2 the effect of the health functional food composition prepared in Example 2 on blood circulation improvement and capillary activity increase was analyzed.
  • the experiment was conducted for adolescents and adults with diseases such as family history of diabetes, family history of hyperlipidemia, chronic fatigue, and blood circulation disorders for about 10 months.
  • the left hand ring finger wrinkling capillaries were measured under a microscope.
  • the microscope used a TR800B Microcirculaton Analyzer, which is used in Korean hospitals and clinics.
  • Example 2 The tablets prepared in Example 2 were taken twice daily, twice daily with water, and the left hand ring finger wrinkling capillaries were measured under a microscope.
  • FIG. 1 is a diagram showing an example of abnormal blood vessel shape. The blood vessels of most patients were not clearly visible and showed abnormal capillary morphology in the twisted state (FIGS. 3 and 4).
  • Figure 3 is a photograph before, after, and after the increase in the activity of the capillary blood vessels when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.
  • Figure 4 is a photograph before, after, and after the increase in activity of adult capillaries when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.
  • FIG. 2 is a diagram showing the shape and number of normal blood vessels.
  • Normal blood vessels typically have 7 to 9 blood vessels in 1 mm, with a diameter of 8 to 20 mm.
  • Figure 3 and 4 after taking the food composition of the present invention, it was confirmed that the distortion of capillaries was reduced, which means that blood circulation was improved and capillary activity was increased (FIGS. 3 and 4).
  • Figure 3 is a photograph before, after, and after the increase in the activity of the capillary blood vessels when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.
  • Figure 4 is a photograph of before and after the increase in the activity of adult capillaries when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.

Abstract

La présente invention concerne une composition d'aliment fonctionnel diététique qui facilite la circulation, inhibe la coagulation du sang par augmentation de l'activité capillaire, et améliore la circulation sanguine.
PCT/KR2015/004533 2014-05-09 2015-05-07 Composition d'aliment fonctionnel diététique améliorant la circulation sanguine ou augmentant l'activité capillaire WO2015170881A1 (fr)

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Application Number Priority Date Filing Date Title
KR1020140055878A KR101469801B1 (ko) 2014-05-09 2014-05-09 혈행개선 또는 모세혈관 활성증가용 건강 기능성 식품 조성물
KR10-2014-0055878 2014-05-09

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106820127A (zh) * 2017-03-11 2017-06-13 北京中科卓尔生物科技有限公司 富硒纳豆精粉及其制作方法

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KR101595496B1 (ko) * 2015-08-13 2016-02-18 농업회사법인 에스에스바이오팜 주식회사 나토키나아제를 함유하는 항산화 및 혈행개선용 기능성 조성물.
CN105595318A (zh) * 2015-11-04 2016-05-25 广东省心血管病研究所 一种有益心脑血管的保健胶囊
KR20170110498A (ko) * 2016-03-23 2017-10-11 (주)에스피엔아이 콘택트렌즈 조성물
KR102101566B1 (ko) * 2018-08-27 2020-04-17 스타링포스 주식회사 모세혈관 출혈 개선 및 방지용 건강기능식품
KR102493427B1 (ko) * 2022-09-20 2023-01-31 박건우 브로멜라인을 포함하는 하지 부종, 산후 부종 등 각종 부종 예방 및 개선용 식품 조성물

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KR19980019986A (ko) * 1996-09-04 1998-06-25 김규식 크롬을 함유하는 기능성 식품
KR20040024774A (ko) * 2002-09-16 2004-03-22 이성표 혈액형별 체질에 적합하도록 제조한 생약 조성물
JP2005029488A (ja) * 2003-07-09 2005-02-03 National Institute Of Advanced Industrial & Technology 血圧降下剤およびＧｌｙ−Ｐｒｏ
KR101086504B1 (ko) * 2009-01-22 2011-11-25 김선옥 혈행개선 및 혈관확장 기능을 가지는 피부 도포용 조성물
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KR20140040568A (ko) * 2012-09-26 2014-04-03 한국 한의학 연구원 동맥경화증 예방 또는 치료용 약학적 조성물

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Publication number Priority date Publication date Assignee Title
CN106820127A (zh) * 2017-03-11 2017-06-13 北京中科卓尔生物科技有限公司 富硒纳豆精粉及其制作方法

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