WO2015170881A1 - Blood circulation improving or capillary activity increasing health functional food composition - Google Patents

Blood circulation improving or capillary activity increasing health functional food composition Download PDF

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WO2015170881A1
WO2015170881A1 PCT/KR2015/004533 KR2015004533W WO2015170881A1 WO 2015170881 A1 WO2015170881 A1 WO 2015170881A1 KR 2015004533 W KR2015004533 W KR 2015004533W WO 2015170881 A1 WO2015170881 A1 WO 2015170881A1
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parts
weight
food composition
blood circulation
extract powder
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PCT/KR2015/004533
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French (fr)
Korean (ko)
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남린
김승배
박정순
황호성
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주식회사 웰솔루션
남린
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof

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  • the present invention relates to a health functional food composition for blood circulation improvement or capillary activity increase.
  • Blood circulation refers to the movement of blood through blood vessels to parts of the body.
  • blood circulation is regulated by a variety of factors, including physical factors such as hematocrit, viscosity, and shear stress caused by blood, as well as changes in blood lipid composition and blood cells (platelets). This is the main factor.
  • Blood circulation improvers prevent the aging of cells and organs and promote cell growth and regeneration by restoring the inhibited blood flow to a normal state, resulting in stiff shoulders and neck, limb tingling, cold hands and feet, and lower body edema caused by peripheral blood circulation disorders. Reduces hair loss symptoms caused by disorders of the scalp blood circulation.
  • Patent Document 1 Republic of Korea Patent No. 10-1086504 (name of the invention: composition for skin application having blood circulation improvement and vasodilation function), "including the step of applying the composition to the skin, improve blood circulation and blood vessels How to expand it.
  • Patent Document 2 Republic of Korea Patent No. 10-1259499 (name of the invention: blood circulation improving composition comprising a ginseng fat-soluble component) relates to "Ginseng fat-soluble component that can be utilized as a pharmaceutical composition or food composition for improving blood circulation" Is described.
  • An object of the present invention is to develop and provide a food composition for blood circulation improvement and capillary activity increase.
  • the present invention is bromelline (pineapple extract powder) 31.8 parts by weight, vitamin C 71.43 parts by weight, vitamin B 12 7.143 parts by weight, nattokinase powder 4.287 parts by weight, ginkgo leaf extract powder 8.1 5 parts by weight, taurine 58.5 parts by weight, chicory root extract powder 27 parts by weight, grape seed extract powder 8.585 parts by weight, Oza extract powder 8.55 parts by weight, L-proline 8.22 parts by weight, turmeric extract powder 6.6 Parts by weight, coenzyme Q10 6.357 parts by weight, octacosanol powder 4.26 parts by weight, curry leaf extract powder 1.32 parts by weight, selenium-containing dry yeast 0.9 parts by weight, chromium-containing dry yeast 0.49 parts, vitamin B 2 0.021 It provides a food composition for improving blood circulation or capillary activity, characterized in that the mixture by weight, 35.922 parts by weight of crystalline cellulose, 2.7 parts by weight of magnesium
  • the bromelain pineapple extract powder
  • GDU means "gelatin digestion unit”
  • the vitamin C is used as a coenzyme of various enzymatic reactions in vivo and is involved in the synthesis of collagen, which is a major protein constituting connective tissues such as skin skeleton, blood vessels and cartilage. It also plays a role in preventing the onset of lipid peroxidation, such as low density lipoprotein (LDL).
  • LDL low density lipoprotein
  • the vitamin B 12 preferably contains 0.05 to 0.3% by weight of vitamin B 12 as an indicator component.
  • vitamin B 12 is converted into methylcobalamin or 5-deoxyadenosylcobalamin in the body to serve as a coenzyme to move a single carbon unit.
  • the nattokinase powder preferably contains 40 to 60% by weight of Bacillus subtlis natto culture powder and 40 to 60% by weight of dextrin.
  • Natokinase powder preferably has fibrinolytic enzyme activity of 17,000-28,000 FU / g (FU stands for "Fibrin Unit"), and when it satisfies the enzyme activity range, it interferes with the coagulation of blood. , Blood flows smoothly.
  • the NATO culture powder is a natural raw material containing enzyme produced by the bacteria derived from Cheonggukjang, contains a large amount of high-quality protein and glutamic acid, etc., and can help to improve blood circulation from the KFDA. It is a recognized raw material.
  • the ginkgo leaf extract powder preferably contains 24 to 30% by weight of flavonol glycosides.
  • Ginkgo biloba extract powder is composed of flavonoid-based compounds such as kaempherol, quercetin and isoramretin, and if it meets the above range, it works by reducing blood clots and expanding blood vessels in the bloodstream. Help improve
  • the taurine acts to suppress the sympathetic nerve of the brain to stabilize blood pressure, increase the output of the heart, to prevent arrhythmia and heart failure.
  • the chicory root extract powder acts to lower triglycerides and cholesterol.
  • the grape seed extract powder functions as an antioxidant, protecting the body from free radicals.
  • the Oja extract powder is prepared by mixing the extract of Schisandra chinensis, wolfberry, casualty, earthenware, bokbunja in the same ratio, and restores vascular system function and blood pressure control.
  • the L-proline (L-Proline) to help the collagen (collagen) production make the skin more healthy, promote the regeneration of cartilage and strengthen the joints, myocardium do.
  • the turmeric extract powder lowers the blood cholesterol level of the human body, improves fat digestion function to prevent atherosclerosis, and lowers the blood sugar of the human body so that blood vessels are not blocked. do.
  • the coenzyme Q10 is, for example, Agrobacterium tumefaciens ( Agrobacterium tumefaciens ), Paracoccus denitrificans ( Pseudomonas aeruginosa ), Pseudomonas aeruginosa
  • Agrobacterium tumefaciens Agrobacterium tumefaciens
  • Paracoccus denitrificans Pseudomonas aeruginosa
  • Pseudomonas aeruginosa Pseudomonas aeruginosa
  • the culture product of may be extracted with hexane, acetone, isopropyl alcohol, ethyl acetate and concentrated or purified to make it suitable for edible use.
  • the octacosanol powder to increase the LDL receptor required when the decomposition of low density lipoprotein (LDL) to promote the decomposition of LDL.
  • LDL low density lipoprotein
  • mevalonate which is involved in the synthesis of cholesterol, the action of cholesterol synthase, and increases the activity of cholesterol degrading enzymes to lower total cholesterol levels.
  • the curry leaf extract powder has an antioxidant component, and serves to protect the digestive tract and support the absorption and activity of iron.
  • the selenium-containing dry yeast has an antioxidant effect of inhibiting cell damage.
  • the chromium-containing dry yeast has an antioxidant action to inhibit cell damage.
  • the vitamin B 2 is a coenzyme involved in various enzymatic reactions, and particularly plays an important role in caloric metabolism.
  • the extraction powder of the material can be used by drying the extracted by the method of hot water extraction commonly used in the art.
  • the material may be prepared by hot water extraction to obtain an extract, and then freeze drying or spray drying.
  • composition of the present invention can be ingested by itself, but may be used in addition to food.
  • examples of the food to be added include meat, grains, caffeine drinks, general beverages, chocolate, dairy products, breads, snacks, confectionery, pizza, jelly, noodles, gums, ice creams, vitamin complexes, but are not necessarily limited thereto.
  • composition of the present invention facilitates blood circulation, increases capillary activity, and exerts an effect on suppressing blood coagulation and improving blood circulation.
  • metabolism is active through this, it is effective in preventing dementia, stroke and heart attack.
  • 1 is a diagram showing an example of abnormal blood vessel shape.
  • FIG. 2 is a diagram showing the shape and number of normal blood vessels.
  • Figure 3 is a photograph before, after, and after the increase in the activity of the capillary blood vessels when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.
  • Figure 4 is a photograph before, after, and after the increase in activity of adult capillaries when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.
  • Example 1 For use in Example 1, a raw material conforming to the standards such as health functional foods, foods, food additives, etc. was purchased. Using electronic balance, bromelline (pineapple extract powder) 31.8 kg, vitamin C 71.43 kg, vitamin B 12 7.143 kg, nattokinase powder 4.287 kg, ginkgo leaf extract powder 8.1 kg, taurine 58.5 kg, Chicory root extract powder 27 kg, grape seed extract powder 8.585 kg, quince extract powder 8.55 kg, L-Proline 8.22 kg, turmeric extract powder 6.6 kg, coenzyme Q10 6.357 kg, octacosanol powder ) 4.26 kg, curry leaf extract powder 1.32 kg, selenium dry yeast 0.9 kg, chromium-containing dry yeast 0.49 kg, vitamin B 2 0.021 kg, crystalline cellulose 35.922 kg, magnesium stearate and 4.5 kg silicon dioxide It was then compressed in a tableting machine to prepare a mixed composition for blood circulation improvement or capillary activity increase.
  • Example 1 the mixed composition prepared in Example 1 was mixed in the mixing ratio described in Example 1 and tableted in a tableting machine. Thereafter, a tablet containing 50,000 ml of ethanol, 2.096 kg of hydroxypropylmethylcellulose, and 0.419 kg of glycerin fatty acid ester was coated on a tablet, and then screened to prepare a tablet-type health functional food composition having a size of 1050 mg.
  • Example 2 the effect of the health functional food composition prepared in Example 2 on blood circulation improvement and capillary activity increase was analyzed.
  • the experiment was conducted for adolescents and adults with diseases such as family history of diabetes, family history of hyperlipidemia, chronic fatigue, and blood circulation disorders for about 10 months.
  • the left hand ring finger wrinkling capillaries were measured under a microscope.
  • the microscope used a TR800B Microcirculaton Analyzer, which is used in Korean hospitals and clinics.
  • Example 2 The tablets prepared in Example 2 were taken twice daily, twice daily with water, and the left hand ring finger wrinkling capillaries were measured under a microscope.
  • FIG. 1 is a diagram showing an example of abnormal blood vessel shape. The blood vessels of most patients were not clearly visible and showed abnormal capillary morphology in the twisted state (FIGS. 3 and 4).
  • Figure 3 is a photograph before, after, and after the increase in the activity of the capillary blood vessels when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.
  • Figure 4 is a photograph before, after, and after the increase in activity of adult capillaries when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.
  • FIG. 2 is a diagram showing the shape and number of normal blood vessels.
  • Normal blood vessels typically have 7 to 9 blood vessels in 1 mm, with a diameter of 8 to 20 mm.
  • Figure 3 and 4 after taking the food composition of the present invention, it was confirmed that the distortion of capillaries was reduced, which means that blood circulation was improved and capillary activity was increased (FIGS. 3 and 4).
  • Figure 3 is a photograph before, after, and after the increase in the activity of the capillary blood vessels when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.
  • Figure 4 is a photograph of before and after the increase in the activity of adult capillaries when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.

Abstract

The present invention relates to a health functional food composition that facilitates circulation, inhibits coagulation of blood by increasing capillary activity, and improves blood circulation.

Description

혈행개선 또는 모세혈관 활성증가용 건강 기능성 식품 조성물Health functional food composition for blood circulation improvement or capillary activity increase
본 발명은 혈행개선 또는 모세혈관 활성증가용 건강 기능성 식품 조성물에 관한 것이다. The present invention relates to a health functional food composition for blood circulation improvement or capillary activity increase.
혈행이란, 혈액이 혈관을 통해서 신체의 각 부분으로 이동하는 것을 의미한다. 인체 내에서 혈행은 다양한 요소에 의해 조절되는데, 혈구수(hematocrit), 점성(viscosity), 혈액에 의한 전단 응력(shear stress) 등과 같은 물리적인 요소뿐만 아니라 혈중 지질 조성의 변화, 혈구세포(혈소판) 등이 주요 요소이다. Blood circulation refers to the movement of blood through blood vessels to parts of the body. In the human body, blood circulation is regulated by a variety of factors, including physical factors such as hematocrit, viscosity, and shear stress caused by blood, as well as changes in blood lipid composition and blood cells (platelets). This is the main factor.
이러한 다양한 요소는 정상 상태에서는 항상성이 잘 유지되어 혈행 조절이 원활이 이루어지지만, 당뇨 등과 같은 질병, 약물, 흡연 등에 의해 혈행 조절 기능이 교란되면, 혈장, 혈소판, 적혈구 등이 과도하게 응집되고, 비정상적인 지혈(abnormal haemostasis)이 발생하여 혈액의 흐름이 저해된다.These various factors maintain homeostasis well under normal conditions and smoothly regulate blood circulation. However, when blood circulation control functions are disturbed by diseases such as diabetes, drugs, and smoking, plasma, platelets, and red blood cells are excessively aggregated and abnormal. Abnormal haemostasis occur, which inhibits blood flow.
혈행 개선제는 저해된 혈액 흐름을 정상 상태로 복원함으로써 세포와 각 기관의 노화를 방지하고, 세포의 성장과 재생을 촉진하여, 말초 혈행 장애로 인한 어깨와 목 결림, 수족 저림, 수족 냉증, 하체 부종, 두피 혈액순환 장애로 인한 탈모 증상 등을 경감시켜 준다. Blood circulation improvers prevent the aging of cells and organs and promote cell growth and regeneration by restoring the inhibited blood flow to a normal state, resulting in stiff shoulders and neck, limb tingling, cold hands and feet, and lower body edema caused by peripheral blood circulation disorders. Reduces hair loss symptoms caused by disorders of the scalp blood circulation.
하지만, 현재까지 개발된 혈행 개선을 위한 여러 가지 의약품들은 대부분 경구 제제이기 때문에 위장 불쾌감, 설사, 복부 팽만감 등과 같은 증상을 초래하고, 이명, 난청, 혈압상승, 심장박동 증가, 위장출혈 등의 부작용을 초래하여 복용을 중단해야 하는 불편함이 발생한다.However, most of the medicines developed to improve blood circulation are oral preparations, which cause symptoms such as gastrointestinal discomfort, diarrhea and bloating, and cause side effects such as tinnitus, deafness, increased blood pressure, increased heart rate, and gastrointestinal bleeding. This causes discomfort that requires you to stop taking it.
이에 기존 혈행 개선제의 부작용을 줄이는 한편, 혈행개선 및 모세혈관 활성을 증가시킬 수 있는 것으로, 생체에 안전하고 적합한 천연물 함유 식품의 개발이 절실한 실정이다. Therefore, while reducing the side effects of the existing blood circulation improving agent, it is possible to increase blood circulation improvement and capillary activity, the development of food products containing natural products safe and suitable for the living body is urgently needed.
[선행기술문헌] [ Prior Art Document ]
[특허문헌] [ Patent Literature ]
(특허문헌 1) 대한민국 등록특허 제10-1086504호(발명의 명칭: 혈행개선 및 혈관확장 기능을 가지는 피부 도포용 조성물)는, "조성물을 피부에 도포하는 단계를 포함하며, 혈행을 개선시키고 혈관을 확장시키는 방법"에 관한 것이 기재되어 있다. (Patent Document 1) Republic of Korea Patent No. 10-1086504 (name of the invention: composition for skin application having blood circulation improvement and vasodilation function), "including the step of applying the composition to the skin, improve blood circulation and blood vessels How to expand it.
(특허문헌 2) 대한민국 등록특허 제10-1259499호 (발명의 명칭: 인삼 지용성 성분을 포함하는 혈행 개선 조성물)에는, "혈행 개선용 약제학적 조성물 또는 식품 조성물로 활용이 가능한 인삼 지용성 성분"에 관한 것이 기재되어 있다. (Patent Document 2) Republic of Korea Patent No. 10-1259499 (name of the invention: blood circulation improving composition comprising a ginseng fat-soluble component) relates to "Ginseng fat-soluble component that can be utilized as a pharmaceutical composition or food composition for improving blood circulation" Is described.
본 발명은 혈행개선 및 모세혈관 활성증가를 위한 식품 조성물을 개발하여 제공하는 것을 목적으로 한다. An object of the present invention is to develop and provide a food composition for blood circulation improvement and capillary activity increase.
상기 목적을 달성하기 위하여, 본 발명은 브로멜라인(파인애플추출분말) 31.8 중량부, 비타민C 71.43 중량부, 비타민B12 7.143 중량부, 나토키나제분말(nattokinase powder) 4.287 중량부, 은행잎추출분말 8.1 중량부, 타우린(taurine) 58.5 중량부, 치커리뿌리추출분말 27 중량부, 포도종자추출분말 8.585 중량부, 오자추출분말 8.55 중량부, L-프롤린(L-Proline) 8.22 중량부, 울금추출분말 6.6 중량부, 코엔자임Q10(coenzymeQ10) 6.357 중량부, 옥타코사놀분말(octacosanol powder) 4.26 중량부, 커리잎추출분말 1.32 중량부, 셀렌함유건조효모 0.9 중량부, 크롬함유건조효모 0.49 중량부, 비타민B2 0.021 중량부, 결정셀룰로오스 35.922 중량부, 스테아린산마그네슘 2.7 중량부 및 이산화규소 4.5 중량부로 혼합된 것을 특징으로 하는 혈행개선 또는 모세혈관 활성 증가용 식품 조성물을 제공한다. In order to achieve the above object, the present invention is bromelline (pineapple extract powder) 31.8 parts by weight, vitamin C 71.43 parts by weight, vitamin B 12 7.143 parts by weight, nattokinase powder 4.287 parts by weight, ginkgo leaf extract powder 8.1 5 parts by weight, taurine 58.5 parts by weight, chicory root extract powder 27 parts by weight, grape seed extract powder 8.585 parts by weight, Oza extract powder 8.55 parts by weight, L-proline 8.22 parts by weight, turmeric extract powder 6.6 Parts by weight, coenzyme Q10 6.357 parts by weight, octacosanol powder 4.26 parts by weight, curry leaf extract powder 1.32 parts by weight, selenium-containing dry yeast 0.9 parts by weight, chromium-containing dry yeast 0.49 parts, vitamin B 2 0.021 It provides a food composition for improving blood circulation or capillary activity, characterized in that the mixture by weight, 35.922 parts by weight of crystalline cellulose, 2.7 parts by weight of magnesium stearate and 4.5 parts by weight of silicon dioxide.
한편, 본 발명의 식품 조성물에 있어서, 상기 브로멜라인(파인애플추출분말)은 바람직하게 활성도가 1,200~2,500 GDU/g인 것이 좋다 ("GDU"는 "gelatin digestion unit"를 의미함). 상기 범위를 만족시킬시, 용이하게 혈액 내 섬유소(Fibrin)를 용해할 수 있고, 혈액의 응고 억제 및 순환을 좋게 하며, 중풍, 심장마비를 예방할 수 있다. 또한, 혈관벽에 붙은 불순물을 효과적으로 분해시킬 수 있다. On the other hand, in the food composition of the present invention, the bromelain (pineapple extract powder) is preferably 1,200 ~ 2500 GDU / g activity ("GDU" means "gelatin digestion unit"). When satisfying the above range, it is possible to easily dissolve fibrin (Fibrin) in the blood, to improve blood clotting suppression and circulation, and to prevent stroke and heart attack. In addition, impurities adhering to the blood vessel wall can be effectively decomposed.
한편, 본 발명의 식품 조성물에 있어서, 상기 비타민 C는 생체 내에서 여러가지 효소반응의 조효소로 쓰이며, 피부 골격, 혈관, 연골 등의 결합조직을 구성하는 주요 단백질인 콜라겐의 합성에 관여한다. 또한, 저밀도지단백질(low density lipoprotein, LDL)등의 지질과산화의 개시를 방지하는 역할도 한다. Meanwhile, in the food composition of the present invention, the vitamin C is used as a coenzyme of various enzymatic reactions in vivo and is involved in the synthesis of collagen, which is a major protein constituting connective tissues such as skin skeleton, blood vessels and cartilage. It also plays a role in preventing the onset of lipid peroxidation, such as low density lipoprotein (LDL).
한편, 본 발명의 식품 조성물에 있어서, 상기 비타민B12은 바람직하게 비타민B12 0.05~0.3중량%를 지표성분으로 함유하는 것이 좋다. 상기 함유량을 만족시킬시, 비타민B12가 체내에서 메틸코발라민(methylcobalamin) 또는 5-데옥시아데노실코발라민(5-deoxyadenosylcobalamin)으로 전환되어 단일 탄소 단위를 이동시키는 조효소 역할을 한다. On the other hand, in the food composition of the present invention, the vitamin B 12 preferably contains 0.05 to 0.3% by weight of vitamin B 12 as an indicator component. When the content is satisfied, vitamin B 12 is converted into methylcobalamin or 5-deoxyadenosylcobalamin in the body to serve as a coenzyme to move a single carbon unit.
한편, 본 발명의 식품 조성물에 있어서, 상기 나토키나제분말(nattokinase powder)은 바람직하게 바실러스 서브틀리스 나토(Bacillus subtlis natto) 배양분말 40~60중량%와 덱스트린 40~60중량%를 함유하는 것이 좋다. 나토키나제분말(nattokinase powder)은 바람직하게 피브린용해효소활성이 17,000~28,000 FU/g이며(FU는 "Fibrin Unit"를 의미함), 상기 효소활성 범위를 만족시킬시, 혈액의 응고작용을 방해하여, 혈액을 원활히 흐르게 한다. 이때, 상기 나토배양분말은 청국장에서 유래한 균이 생산한 효소가 포함된 자연의 원료로, 다량의 고품질 단백질과 글루탐산 등이 포함되어 있으며, 식약처로부터 '혈행개선에 도움을 줄 수 있음'을 인정받은 원료이다. On the other hand, in the food composition of the present invention, the nattokinase powder preferably contains 40 to 60% by weight of Bacillus subtlis natto culture powder and 40 to 60% by weight of dextrin. . Natokinase powder preferably has fibrinolytic enzyme activity of 17,000-28,000 FU / g (FU stands for "Fibrin Unit"), and when it satisfies the enzyme activity range, it interferes with the coagulation of blood. , Blood flows smoothly. At this time, the NATO culture powder is a natural raw material containing enzyme produced by the bacteria derived from Cheonggukjang, contains a large amount of high-quality protein and glutamic acid, etc., and can help to improve blood circulation from the KFDA. It is a recognized raw material.
한편, 본 발명의 식품 조성물에 있어서, 상기 은행잎추출분말은 바람직하게 플라보놀배당체 24~30중량%를 함유하는 것이 좋다. 은행잎추출분말은 플라보노이드(flavonoid)계 화합물인 캠페롤(kaempherol) 및 케르세틴(Quercetin)과 이소람레틴 등으로 구성되어 있으며, 상기 범위를 만족시킬 경우, 혈류 내 혈전감소 및 혈관 확장 기전에 작용하여 혈행 개선을 돕는다. On the other hand, in the food composition of the present invention, the ginkgo leaf extract powder preferably contains 24 to 30% by weight of flavonol glycosides. Ginkgo biloba extract powder is composed of flavonoid-based compounds such as kaempherol, quercetin and isoramretin, and if it meets the above range, it works by reducing blood clots and expanding blood vessels in the bloodstream. Help improve
한편, 본 발명의 식품 조성물에 있어서, 상기 타우린(taurine)은 뇌의 교감신경을 억제해 혈압을 안정시키고, 심장의 수출력을 증가시켜, 부정맥이나 심부전을 예방하는 작용을 한다. On the other hand, in the food composition of the present invention, the taurine (taurine) acts to suppress the sympathetic nerve of the brain to stabilize blood pressure, increase the output of the heart, to prevent arrhythmia and heart failure.
한편, 본 발명의 식품 조성물에 있어서, 상기 치커리뿌리추출분말은 중성지방 및 콜레스테롤을 저하시키는 작용을 한다. On the other hand, in the food composition of the present invention, the chicory root extract powder acts to lower triglycerides and cholesterol.
한편, 본 발명의 식품 조성물에 있어서, 상기 포도종자추출분말은 항산화제 기능을 하여, 활성산소로부터 신체를 보호하는 작용을 한다. On the other hand, in the food composition of the present invention, the grape seed extract powder functions as an antioxidant, protecting the body from free radicals.
한편, 본 발명의 식품 조성물에 있어서, 상기 오자추출분말은 오미자, 구기자, 사상자, 토사자, 복분자를 동일한 비율로 혼합하여 추출한 것을 분말형태로 제조한 것이며, 혈관 계통 기능 회복 및 혈압조절 작용을 한다. On the other hand, in the food composition of the present invention, the Oja extract powder is prepared by mixing the extract of Schisandra chinensis, wolfberry, casualty, earthenware, bokbunja in the same ratio, and restores vascular system function and blood pressure control.
한편, 본 발명의 식품 조성물에 있어서, 상기 L-프롤린(L-Proline)은 콜라겐(교원질) 생성을 도움으로써, 피부를 좀 더 건장하게 하고, 연골의 재생 촉진과 관절, 심근을 강화하는 작용을 한다. On the other hand, in the food composition of the present invention, the L-proline (L-Proline) to help the collagen (collagen) production, make the skin more healthy, promote the regeneration of cartilage and strengthen the joints, myocardium do.
한편, 본 발명의 식품 조성물에 있어서, 상기 울금추출분말은 인체의 혈중 콜레스테롤 수치를 낮추어 주고, 지방소화 기능을 향상시켜주어서 동맥경화를 예방시켜주며, 혈관이 막히지 않도록 인체의 혈당을 낮추어 주는 작용을 한다. On the other hand, in the food composition of the present invention, the turmeric extract powder lowers the blood cholesterol level of the human body, improves fat digestion function to prevent atherosclerosis, and lowers the blood sugar of the human body so that blood vessels are not blocked. do.
한편, 본 발명의 식품 조성물에 있어서, 상기 코엔자임Q10(coenzymeQ10)은 일 예로 아그로박테리엄 투메파시엔스(Agrobacterium tumefaciens), 파라콕커스 데니트리피칸스(Paracoccus denitrificans), 슈도모나스 에루지노사(Pseudomonas aeruginosa)의 배양산물을 헥산, 아세톤, 이소프로필알코올, 초산에틸로 추출하고 이를 농축 또는 정제하여 식용에 적합하도록 한 것을 사용할 수 있다. Meanwhile, in the food composition of the present invention, the coenzyme Q10 (coenzyme Q10) is, for example, Agrobacterium tumefaciens ( Agrobacterium tumefaciens ), Paracoccus denitrificans ( Pseudomonas aeruginosa ), Pseudomonas aeruginosa The culture product of may be extracted with hexane, acetone, isopropyl alcohol, ethyl acetate and concentrated or purified to make it suitable for edible use.
한편, 본 발명의 식품 조성물에 있어서, 상기 옥타코사놀분말(octacosanol powder)은 유해콜레스테롤(low density lipoprotein, LDL)이 분해될 때 필요한 LDL 수용체를 증가시켜 LDL의 분해를 촉진시킨다. 또한, 콜레스테롤의 전구물질로서 콜레스테롤의 합성에 관여하는 메발로네트(mevalo nate)의 형성과 콜레스테롤 합성효소의 작용을 억제하고, 콜레스테롤 분해 효소의 활성을 높여 총 콜레스테롤 수치를 낮추어준다.On the other hand, in the food composition of the present invention, the octacosanol powder (octacosanol powder) to increase the LDL receptor required when the decomposition of low density lipoprotein (LDL) to promote the decomposition of LDL. In addition, as a precursor of cholesterol, it inhibits the formation of mevalonate, which is involved in the synthesis of cholesterol, the action of cholesterol synthase, and increases the activity of cholesterol degrading enzymes to lower total cholesterol levels.
한편, 본 발명의 식품 조성물에 있어서, 상기 커리잎추출분말은 항산화 요소를 가지고 있으며, 소화관을 보호하고 철의 흡수와 활성을 지지해 주는 작용을 한다. On the other hand, in the food composition of the present invention, the curry leaf extract powder has an antioxidant component, and serves to protect the digestive tract and support the absorption and activity of iron.
한편, 본 발명의 식품 조성물에 있어서, 상기 셀렌함유건조효모는 세포손상을 억제하는 항산화 작용을 한다. On the other hand, in the food composition of the present invention, the selenium-containing dry yeast has an antioxidant effect of inhibiting cell damage.
한편, 본 발명의 식품 조성물에 있어서, 상기 크롬함유건조효모는 세포손상을 억제하는 항산화 작용을 한다. On the other hand, in the food composition of the present invention, the chromium-containing dry yeast has an antioxidant action to inhibit cell damage.
한편, 본 발명의 식품 조성물에 있어서, 상기 비타민 B2는 조효소로서 여러가지 효소반응에 관여하고, 특히 열량대사에 중요한 작용을 한다.On the other hand, in the food composition of the present invention, the vitamin B 2 is a coenzyme involved in various enzymatic reactions, and particularly plays an important role in caloric metabolism.
한편, 본 발명의 식품 조성물에 있어서, 상기 재료 중 추출분말들은 본 발명의 기술분야에서 통상적으로 사용하는 열수 추출의 방법으로 추출한 것을 건조시켜 사용할 수 있다. 일 예로, 재료를 열수 추출하여 추출물 수득 후, 동결건조 또는 분무건조함으로써 제조될 수 있다. On the other hand, in the food composition of the present invention, the extraction powder of the material can be used by drying the extracted by the method of hot water extraction commonly used in the art. For example, the material may be prepared by hot water extraction to obtain an extract, and then freeze drying or spray drying.
한편, 본 발명의 조성물은 그 자체로도 섭취 가능하나, 그 외에 식품에 첨가되어 사용될 수도 있다. 첨가 대상 식품은 일 예로 육류, 곡류, 카페인 음료, 일반음료, 초콜렛, 유제품, 빵류, 스낵류, 과자류, 피자, 젤리, 면류, 껌류, 아이스크림류, 비타민 복합제 등이 있으나, 반드시 이에 한정되는 것은 아니다. On the other hand, the composition of the present invention can be ingested by itself, but may be used in addition to food. Examples of the food to be added include meat, grains, caffeine drinks, general beverages, chocolate, dairy products, breads, snacks, confectionery, pizza, jelly, noodles, gums, ice creams, vitamin complexes, but are not necessarily limited thereto.
본 발명의 조성물은 혈행을 원활하게 하고, 모세혈관 활성을 증가시켜, 혈액의 응고 억제 및 혈액순환 개선에 효과를 발휘한다. 또한, 이를 통해 신진대사가 활발해지며, 치매, 중풍, 심장마비 등을 예방하는 효과가 있다. The composition of the present invention facilitates blood circulation, increases capillary activity, and exerts an effect on suppressing blood coagulation and improving blood circulation. In addition, metabolism is active through this, it is effective in preventing dementia, stroke and heart attack.
도 1은 비정상적인 혈관 모양의 예를 보여주는 그림이다. 1 is a diagram showing an example of abnormal blood vessel shape.
도 2는 정상적인 혈관의 모양과 갯수를 보여주는 그림이다.2 is a diagram showing the shape and number of normal blood vessels.
도 3은 본 발명의 혈행개선 및 모세혈관 활성증가용 건강 기능성 식품 조성물을 10개월간 복용하였을 때, 청소년 모세혈관의 활성 증가 전·후, 사진이다. Figure 3 is a photograph before, after, and after the increase in the activity of the capillary blood vessels when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.
도 4는 본 발명의 혈행개선 및 모세혈관 활성증가용 건강 기능성 식품 조성물을 10개월간 복용하였을 때, 성인 모세혈관의 활성 증가 전·후, 사진이다. Figure 4 is a photograph before, after, and after the increase in activity of adult capillaries when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.
이하, 본 발명의 내용에 대해 하기 실시예에서 더욱 상세히 설명하지만, 본 발명의 권리범위가 하기 실시예에만 한정되는 것은 아니고, 이와 등가의 기술적 사상의 변형까지를 포함한다.Hereinafter, the content of the present invention will be described in more detail in the following examples, but the scope of the present invention is not limited only to the following examples, and includes modifications of equivalent technical ideas.
[실시예 1: 혈행개선 또는 모세혈관 활성증가용 혼합조성물 타정 제조]Example 1 Preparation of a Tablet Composition for Combining Blood Circulation Improvement or Capillary Activity
실시예 1에 사용하기 위해 건강기능식품공전, 식품공전, 식품첨가물공전 등의 기준 규격에 적합한 원료를 구입하였다. 전자저울을 사용하여 브로멜라인(파인애플추출분말) 31.8 kg, 비타민C 71.43 kg, 비타민B12 7.143 kg, 나토키나제분말(nattokinase powder) 4.287 kg, 은행잎추출분말 8.1 kg, 타우린(taurine) 58.5 kg, 치커리뿌리추출분말 27 kg, 포도종자추출분말 8.585 kg, 오자추출분말 8.55 kg, L-프롤린(L-Proline) 8.22 kg, 울금추출분말 6.6 kg, 코엔자임Q10(coenzymeQ10) 6.357 kg, 옥타코사놀분말(octacosanol powder) 4.26 kg, 커리잎추출분말 1.32 kg, 셀렌함유건조효모 0.9 kg, 크롬함유건조효모 0.49 kg, 비타민B2 0.021 kg, 결정셀룰로오스 35.922 kg, 스테아린산마그네슘 2.7kg 및 이산화규소 4.5 kg을 칭량 및 균일혼합하고, 타정기에서 타정하여 혈행개선 또는 모세혈관 활성증가용 혼합 조성물을 제조하였다. For use in Example 1, a raw material conforming to the standards such as health functional foods, foods, food additives, etc. was purchased. Using electronic balance, bromelline (pineapple extract powder) 31.8 kg, vitamin C 71.43 kg, vitamin B 12 7.143 kg, nattokinase powder 4.287 kg, ginkgo leaf extract powder 8.1 kg, taurine 58.5 kg, Chicory root extract powder 27 kg, grape seed extract powder 8.585 kg, quince extract powder 8.55 kg, L-Proline 8.22 kg, turmeric extract powder 6.6 kg, coenzyme Q10 6.357 kg, octacosanol powder ) 4.26 kg, curry leaf extract powder 1.32 kg, selenium dry yeast 0.9 kg, chromium-containing dry yeast 0.49 kg, vitamin B 2 0.021 kg, crystalline cellulose 35.922 kg, magnesium stearate and 4.5 kg silicon dioxide It was then compressed in a tableting machine to prepare a mixed composition for blood circulation improvement or capillary activity increase.
[실시예 2: 코팅된 혈행개선 및 모세혈관 활성증가용 타정 제조]Example 2 Preparation of Coated Tablets for Improved Blood Circulation and Capillary Activity
본 실시예에서는 상기 실시예 1에서 제조된 혼합조성물을 사용하여 혈행개선 및 모세혈관 활성증가용 건강 기능성 식품 조성물을 제조하고자 하였다. In this embodiment, to prepare a health functional food composition for improving blood circulation and capillary activity using the mixed composition prepared in Example 1.
상기 실시예 1에서 제조된 혼합조성물을 일 예로, 실시예 1에 기재된 배합비대로 혼합하여 타정기에서 타정하였다. 그 후, 타정분에 주정 50,000 ml, 히드록시프로필메틸셀룰로오스 2.096 kg, 글리세린지방산에스테르 0.419 kg이 배합된 액을 코팅하고, 선별하여 1050 mg 크기의 정제형 건강 기능성 식품 조성물을 제조하였다.For example, the mixed composition prepared in Example 1 was mixed in the mixing ratio described in Example 1 and tableted in a tableting machine. Thereafter, a tablet containing 50,000 ml of ethanol, 2.096 kg of hydroxypropylmethylcellulose, and 0.419 kg of glycerin fatty acid ester was coated on a tablet, and then screened to prepare a tablet-type health functional food composition having a size of 1050 mg.
[실험예 1: 혈행개선 및 모세혈관 활성증가 효능 분석]Experimental Example 1: Analysis of blood circulation improvement and capillary activity increase efficacy
본 실험예에서는 상기 실시예 2에서 제조된 건강 기능성 식품 조성물이 혈행개선 및 모세혈관 활성증가에 미치는 효능을 분석하고자 하였다. 당뇨가족력, 고지혈 가족력, 만성피로, 혈액순환 장애 등의 질병을 가지고 있는 청소년 및 성인을 대상으로 약 10개월 동안 실험을 진행하였다. 실험 진행 전, 왼손약지 조갑주름 모세혈관을 현미경으로 측정하였다. 현미경은 국내 병·의원 급에서 사용하는 티알800비 마이크로컬큐라톤(TR800B Microcirculaton Analyzer)장치를 사용하였다.In this experimental example, the effect of the health functional food composition prepared in Example 2 on blood circulation improvement and capillary activity increase was analyzed. The experiment was conducted for adolescents and adults with diseases such as family history of diabetes, family history of hyperlipidemia, chronic fatigue, and blood circulation disorders for about 10 months. Before proceeding with the experiment, the left hand ring finger wrinkling capillaries were measured under a microscope. The microscope used a TR800B Microcirculaton Analyzer, which is used in Korean hospitals and clinics.
상기 실시예 2에서 제조된 타정을 1일 2회, 1회 2정을 물과 함께 매일 복용하고, 왼손약지 조갑주름 모세혈관을 현미경으로 측정하였다. The tablets prepared in Example 2 were taken twice daily, twice daily with water, and the left hand ring finger wrinkling capillaries were measured under a microscope.
실험 결과, 본 발명의 건강 기능성 식품 조성물 복용 전에는 도 1과 유사하나 형태를 나타내었다. 도 1은 비정상적인 혈관 모양의 예를 보여주는 그림이다. 대부분의 환자들의 혈관은 명확하게 보이지 않았으며, 꼬여있는 상태의 비정상적인 모세혈관의 형태를 나타냈다 (도 3, 도 4). 도 3은 본 발명의 혈행개선 및 모세혈관 활성증가용 건강 기능성 식품 조성물을 10개월간 복용하였을 때, 청소년 모세혈관의 활성 증가 전·후, 사진이다. 도 4는 본 발명의 혈행개선 및 모세혈관 활성증가용 건강 기능성 식품 조성물을 10개월간 복용하였을 때, 성인 모세혈관의 활성 증가 전·후, 사진이다. As a result of the experiment, before taking the health functional food composition of the present invention is similar to Figure 1, but showed a form. 1 is a diagram showing an example of abnormal blood vessel shape. The blood vessels of most patients were not clearly visible and showed abnormal capillary morphology in the twisted state (FIGS. 3 and 4). Figure 3 is a photograph before, after, and after the increase in the activity of the capillary blood vessels when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months. Figure 4 is a photograph before, after, and after the increase in activity of adult capillaries when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.
한편, 본 발명의 실시예 2의 식품 조성물 복용 후에는 도 2와 유사한 형태를 나타내었다. 도 2는 정상적인 혈관의 모양과 갯수를 보여주는 그림이다. 정상적인 혈관은 통상적으로 1㎜에 7~9개의 혈관이 위치해야 하며, 지름은 8~20㎜를 나타내야 한다. 도 3 및 4에서 확인되는 바와 같이 본 발명의 식품 조성물 복용 후, 모세혈관의 왜곡이 감소한 것으로 확인되었는데, 이는 혈행이 개선되고 모세혈관의 활성이 증가되었다는 것을 의미한다 (도 3, 도 4). 도 3은 본 발명의 혈행개선 및 모세혈관 활성증가용 건강 기능성 식품 조성물을 10개월간 복용하였을 때, 청소년 모세혈관의 활성 증가 전·후, 사진이다. 도 4는 본 발명의 혈행개선 및 모세혈관 활성증가용 건강 기능성 식품 조성물을 10개월간 복용하였을 때, 성인 모세혈관의 활성 증가 전·후, 사진이다. On the other hand, after taking the food composition of Example 2 of the present invention was shown a form similar to FIG. 2 is a diagram showing the shape and number of normal blood vessels. Normal blood vessels typically have 7 to 9 blood vessels in 1 mm, with a diameter of 8 to 20 mm. 3 and 4, after taking the food composition of the present invention, it was confirmed that the distortion of capillaries was reduced, which means that blood circulation was improved and capillary activity was increased (FIGS. 3 and 4). Figure 3 is a photograph before, after, and after the increase in the activity of the capillary blood vessels when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months. Figure 4 is a photograph of before and after the increase in the activity of adult capillaries when the health functional food composition for improving blood circulation and capillary activity of the present invention for 10 months.

Claims (2)

  1. 브로멜라인(파인애플추출분말) 31.8 중량부, 비타민C 71.43 중량부, 비타민B12 7.143 중량부, 나토키나제분말(nattokinase powder) 4.287 중량부, 은행잎추출분말 8.1 중량부, 타우린(taurine) 58.5 중량부, 치커리뿌리추출분말 27 중량부, 포도종자추출분말 8.585 중량부, 오자추출분말 8.55 중량부, L-프롤린(L-Proline) 8.22 중량부, 울금추출분말 6.6 중량부, 코엔자임Q10(coenzymeQ10) 6.357 중량부, 옥타코사놀분말(octacosanol powder) 4.26 중량부, 커리잎추출분말 1.32 중량부, 셀렌함유건조효모 0.9 중량부, 크롬함유건조효모 0.49 중량부, 비타민B2 0.021 중량부, 결정셀룰로오스 35.922 중량부, 스테아린산마그네슘 2.7 중량부 및 이산화규소 4.5 중량부로 혼합된 것을 특징으로 하는 혈행개선 또는 모세혈관 활성증가용 식품 조성물.Bromelain (pineapple extract powder) 31.8 parts by weight, vitamin C 71.43 parts by weight, vitamin B 12 7.143 parts by weight, nattokinase powder 4.287 parts by weight, ginkgo leaf extract powder 8.1 parts by weight, taurine 58.5 parts by weight , 27 parts by weight of chicory root extract powder, 8.585 parts by weight of grape seed extract powder, 8.55 parts by weight of quinine extract powder, 8.22 parts by weight of L-Proline, 6.6 parts by weight turmeric extract powder, 6.357 parts by weight coenzyme Q10 (coenzyme Q10) Part, octacosanol powder 4.26 parts by weight, curry leaf extract powder 1.32 parts by weight, selenium dry yeast 0.9 parts by weight, chromium-containing dry yeast 0.49 parts by weight, vitamin B 2 0.021 parts by weight, crystalline cellulose 35.922 parts, stearic acid Food composition for blood circulation improvement or capillary activity, characterized in that the mixture of 2.7 parts by weight of magnesium and 4.5 parts by weight of silicon dioxide.
  2. 제1항에 있어서,The method of claim 1,
    상기 브로멜라인(파인애플추출분말)은, The bromelain (pineapple extract powder),
    활성도가 1,200~2,500 GDU/g인 것을 특징으로 하는 혈행개선 또는 모세혈관 활성증가용 식품 조성물.Food composition for blood circulation improvement or capillary activity, characterized in that the activity is 1,200 ~ 2,500 GDU / g.
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