CN102302153A - Health-care composition and preparation method and application thereof - Google Patents
Health-care composition and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a health-care composition. The health-care composition is made from the following raw materials in parts by weight: 2 to 10 parts of salvia miltiorrhiza, 1 to 8 parts of Notoginseng roots and 2 to 10 parts of Gynostemma. The health-care composition is mainly made from natural medicinal herbs, has the effects of improving blood circulation, enhancing hypoxia tolerance, lowering blood lipid level, protecting against oxidation and reducing blood sugar level. The invention also provides a preparation method and application of the health-care composition.
Description
Technical field
The present invention relates to field of food, particularly a kind of that mainly process by natural medicinal plant, have improve blood circulation, improve anoxia endurance, health composition and the manufacturing approach and the purposes of auxiliary antilipemic, anti-oxidant and auxiliary hyperglycemic effect.
Background technology
Cardiovascular and cerebrovascular disease is a human killer.Higher, the blood fluidity variation of middle-aged and old blood viscosities more than 50 years old of suitable vast scale; There is blood pressure in various degree higher; Or blood fat is higher, blood vessel has sclerosis in various degree, or situation such as local microcirculation variation occur, and health is in sub-health state.
The numerous person in middle and old age masses generally pursue and improve the quality of living, longevity, and hope can avoid suffering from painstaking effort brain pipe disease.Along with the raising of growth in the living standard and hygiene and health know-how, this hope is day by day strong.
Guangdong useful pseudo-ginseng among the people or red sage root Baoshang are ground into the health care custom that powder is taken after mixing it with water as herbal cuisine or with pseudo-ginseng.For taking convenience, many elderlys require to be processed into medicament and take.Therefore be necessary to develop a preparation preferably,, help them to reduce the generation of cardiovascular and cerebrovascular disease, improve the quality of living, promote longevity to satisfy the needs of numerous the elderly to the daily health caring of cardiovascular and cerebrovascular.
Summary of the invention
The object of the present invention is to provide a kind of that mainly process by natural medicinal plant, have improve blood circulation, improve anoxia endurance, the health composition of auxiliary antilipemic, anti-oxidant and auxiliary hyperglycemic effect.
Health composition of the present invention is processed by the raw material of following parts by weight: 2～10 parts of the reds sage root, 1～8 part of pseudo-ginseng, 2～10 parts of gynostemma pentaphylla.
Preferably, said health composition is processed by the raw material of following parts by weight: 3.43 parts of the reds sage root, 1 part of pseudo-ginseng, 2.84 parts of gynostemma pentaphylla.
The red sage root, nature and flavor are bitter, tepor, go into the heart, Liver Channel.The function promoting blood circulation, inducing meastruation to relieve menalgia, the relieving restlessness that clears away heart-fire, the cool blood carbuncle that disappears.Be used for chest impediment and cardialgia, gastral cavity abdomen hypochondriac pain ， wei lump in the abdomen is gathered, hot numbness pain, and dysphoria and insomnia, irregular menstruation, dysmenorrhoea is through closing, and sore swells and ache.
" herbal classic ": " main trusted subordinate's perverse trend, borborygmus are faint as leaking water, and fever and chills gather; The Po wei removes lump in the abdomen, ends dysphoria, beneficial gas.”
" not Lu ": " nourish blood, remove trusted subordinate's chronic illness knot gas, stiff lumbar vertebra, pin numbness; Exorcising stays heat, obeys sharp people for a long time.”
Huang Huaidong etc.; The red sage root is to patients with coronary heart disease blood plasma serotonin level and hemorheological influence [Chinese basic unit medical science 1997; 4 (4): 219], research shows: the red sage root has the anti-blood vessel of opening, and improves between myocardium microcirculatory perfusion; Improve cardiac muscle to the hypoxic-ischemic tolerance, the high concentration red sage root can suppress the blood platelet dense granule and discharge 5-HT; Provable thus, the red sage root can stop 5-HT to discharge, and improves viscosity of blood and high blood coagulation state, is the active drug of prevention and treatment coronary heart disease.
Deng Shizhou; The observation that liquid salvia influences 31 routine patients with coronary heart disease Hemorheology (the new traditional Chinese medical science 1994,1:59-60), the prompting liquid salvia can reduce blood viscosity really; Change the electric charge of erythrocyte membrane; Increase the deformability of cell, reduce hematoblastic cohesion performance, play the purpose that the control cardiovascular and cerebrovascular disease breaks out.
Pseudo-ginseng (being commonly called as pseudo-ginseng), hemostasis, blood looses; Detumescence, analgesic therapy.Control haematemesis, hemoptysis, bleeding from five sense organs or subcutaneous tissue is had blood in stool, bloody flux, uterine bleeding ， wei lump in the abdomen, postpartum anemic fainting, lochia is not fallen and is pounced on hemostasis not down, traumatism and bleeding, the carbuncle pain that swells.
" detailed outline ": " hemostasis, the blood that looses, analgesic therapy.Gold sword arrow is hindered, and falls and pounces on the cane sore, and blood goes out incessantly, chew mashed being coated with, or for mixing it in the end, its blood ends promptly.Also main the haematemesis, bleeding from five sense organs or subcutaneous tissue, following blood, bloody flux, metrorrhagia, incessant menorrhea, postpartum extravesated blood not down, blood fortune, the blood pain, Akamu, carbuncle is swollen, tiger stings, snakebite is all sick.”
" beautiful Chinese catalpa medicine is separated ": " each battalion hemostasis, the capable stasis of blood of promoting blood circulation, row hemostasis and hold back new blood.All postpartum, menstrual period, fall and beat, carbuncle is swollen, and all hemostasis are all broken; All nosebleed, uterine bleeding, knife wound, arrow wounds of telling, all new blood all end.”
He Jiyuan, Wu Yanjia; Pseudo-ginseng is to the influence (popular science and technology 2009 of hyperlipidemia rats antioxidation; 9:90); Experimental result shows: raise with pseudo-ginseng to hyperlipidemia rats and can significantly reduce the level of lipid in the body, it shows and can reduce rat blood serum T-CHOL (TC), triglycerides (TG) and MDA (MDA) level and improve superoxide dismutase (SOD) activity.Explain that pseudo-ginseng has certain antioxidation.This result of study shows, raises to occur SOD, catalase (CAT), the reduction of nitric oxide (NO) and the rising of MDA behind 12 all high lipid foods to rat; After adding pseudo-ginseng, MDA generates significantly and reduces, and SOD, CAT and NO obviously improve.The result shows that pseudo-ginseng has efficient removing oxygen radical, antioxidation, and the prompting pseudo-ginseng can be used for the supplemental treatment of clinical antioxidation.
Gynostemma pentaphylla, qi-restoratives, heat-clearing, detoxifcation.It is weak to be used for body void, nephrasthenia emission, leukopenia, hyperlipidemia, virus hepatitis, chronic gastroenteritis, chronic bronchitis.
Zhou Liang etc.; Gynostemma pentaphyllum total saponin is to influence (the Chinese applied physiology magazine of experimental hyperlipidemia rat fat and level of lipid; 2008,24 (2): 205-208), research shows; Gynostemma pentaphyllum total saponin can significantly improve the activity of body superoxide dismutase (SOD), catalase (CTA) and serum glutathione peroxidase (GSH-Px); Suppress the generation of lipid peroxidation product (MDA) simultaneously and/or accelerate its removing, thereby the peroxidatic reaction of lipid of effectively preventing body reduces generation, the development of coronary heart disease (CHD) and atherosclerotic (AS).
Yu Wenhui etc., gypenosides is to influence [Chinese animal doctor's magazine, 2010 of old and feeble rat anti oxidative function; 46 (1): 40-41], the result of study prompting, gypenosides (GPS) can enhancing body be removed the free radical ability; Improve antioxidant ability of organism, thereby play anti-aging effects.
The present invention also provides a kind of and is used to improve blood circulation, improves anoxia endurance, the preparation method of the health composition of auxiliary antilipemic, anti-oxidant and auxiliary hyperglycemic, and it comprises the following steps:
A, press column weight amount umber and take by weighing raw material: 2～10 parts of the reds sage root, 1～8 part of pseudo-ginseng, 2～10 parts of gynostemma pentaphylla;
B, get the red sage root with 30～97% alcohol extract 1～3 time, each 0.5～3 hour, filter, merging filtrate, reclaim ethanol after soup subsequent use; Dregs of a decoction water extracts 1～2 time, and each 0.5～3 hour, filter, filtrating and above-mentioned combining medicine concentrate, and drying is ground into fine powder;
C, get pseudo-ginseng, be ground into fine powder, cross 30～600 orders;
D, get the gynostemma pentaphylla water and extract 1～3 time, each 1～3 hour, filter; Be concentrated to relative density be 1.05～1.5, said relative density is 60 ℃ of mensuration, adds ethanol and reaches 30～80% to containing the alcohol amount; Stir, left standstill 1～72 hour, filter; Filtrate recycling ethanol, concentrated, dry, be ground into fine powder;
E, above-mentioned three kinds of fine powders are mixed process preparation.
The present invention also provide above-mentioned health composition as be used to improve blood circulation, improve anoxia endurance, the purposes of the health food of auxiliary antilipemic, anti-oxidant and auxiliary hyperglycemic.Preferably, described health food is capsule, tablet, granule, pill, pill, lozenge, mixture, oral solution, powder, soft extract, syrup, more preferably capsule, tablet, granule, pill.
The specific embodiment
For making the present invention be more prone to understand, will further set forth specific embodiment of the present invention below.
Preparation example one: take by weighing the red sage root 1000 grams, pseudo-ginseng 100 grams, gynostemma pentaphylla 1000 grams.
1, get the red sage root with 30～97% alcohol extract 1～3 time, each 0.5～3 hour, filter, merging filtrate, reclaim ethanol after soup subsequent use; Dregs of a decoction water extracts 1～2 time, and each 0.5～3 hour, filter, filtrating and above-mentioned combining medicine concentrate, and drying is ground into fine powder;
2, get pseudo-ginseng, be ground into fine powder, cross 30～300 orders;
3, get the gynostemma pentaphylla water and extract 1～3 time, each 1～3 hour, filter, be concentrated to relative density be 1.03～1.5 (60 ℃ of surveys); Add ethanol and reach 40～75%, stir, left standstill 0.5～48 hour, filter to containing the alcohol amount; Filtrate recycling ethanol, concentrated, dry, be ground into fine powder;
Three kinds of powder mixings with above-mentioned steps makes are packed into capsule, get final product.
Preparation example two: take by weighing the red sage root 3430 grams, pseudo-ginseng 1000 grams, gynostemma pentaphylla 2840 grams.
1, get the red sage root with 30～97% alcohol extract 1～3 time, each 0.5～3 hour, filter, merging filtrate, reclaim ethanol after soup subsequent use; Dregs of a decoction water extracts 1～2 time, and each 0.5～3 hour, filter, filtrating and above-mentioned combining medicine concentrate, and drying is ground into fine powder;
2, get pseudo-ginseng, be ground into fine powder, cross 30～300 orders;
3, get the gynostemma pentaphylla water and extract 1～3 time, each 1～3 hour, filter, be concentrated to relative density be 1.03～1.40 (60 ℃ of surveys); Add ethanol and reach 40～75%, stir, left standstill 0.5～48 hour, filter to containing the alcohol amount; Filtrate recycling ethanol, concentrated, dry, be ground into fine powder;
Three kinds of powder mixings with above-mentioned steps makes are packed into capsule, get final product.
Preparation example three: take by weighing the red sage root 1000 grams, pseudo-ginseng 300 grams, gynostemma pentaphylla 800 grams.
1, get the red sage root with 30～97% alcohol extract 1～3 time, each 0.5～3 hour, filter, merging filtrate, reclaim ethanol after soup subsequent use; Dregs of a decoction water extracts 1～2 time, and each 0.5～3 hour, filter, filtrating and above-mentioned combining medicine concentrate, and drying is ground into fine powder;
2, get pseudo-ginseng, be ground into fine powder, cross 30～300 orders;
3, get the gynostemma pentaphylla water and extract 1～3 time, each 1～3 hour, filter, be concentrated to relative density be 1.03～1.40 (60 ℃ of surveys); Add ethanol and reach 40～75%, stir, left standstill 0.5～48 hour, filter to containing the alcohol amount; Filtrate recycling ethanol, concentrated, dry, be ground into fine powder;
Three kinds of powder mixings with above-mentioned steps makes are packed into capsule, get final product.
Product of the present invention to improve blood circulation, improve anoxia endurance, auxiliary antilipemic, anti-oxidant and auxiliary hyperglycemic have effect preferably, manufacturing approach is unique, feasible, is fit to the application of pharmaceutical factory, health food factory.
For the inventor entrusts the experimental study of Guangdong Pharmaceutical University to health composition of the present invention (below be called the pseudo-ginseng capsule of red sage root) pharmacodynamics, wherein pseudo-ginseng capsule of red sage root medicinal extract is that above-mentioned preparation example two prepares, and is specific as follows below:
One, the pseudo-ginseng capsule of red sage root is to the influence of mouse normal pressure resisting oxygen lack
1 test material
1.1 main agents
1.2 medicine
Pseudo-ginseng capsule of red sage root medicinal extract: 2.56g crude drug/g, lot number: 20110225, the Dongguan City Asia Pharmaceutical Co., Ltd provides; Compound danshen dripping pills: specification: 27mg/ ball, Tianjin Tasly Pharmaceutical Co., Ltd, lot number: 100321.
1.3 test dose
Pseudo-ginseng capsule of red sage root clinical every day of consumption is 7.68g crude drug/d (1.28g crude drug/0.5g/ grain; A 2-3 grain; One day secondary), become body weight for humans in 60kg, average dosage is 0.128g crude drug/kg/d; Basic, normal, high three dose groups of this test mice are made as 1.28,2.56 respectively, 5.12g crude drug/kg/d, and above-mentioned dosage is 10,20,40 times (according to the weight) of clinical medicine dose; Compound danshen dripping pills clinical every day of consumption be 5.39g crude drug/d (0.1797g crude drug/27mg/ ball, one time 10, three times on the one); Become body weight for humans in 60kg; Average dosage is 0.090g crude drug/kg/d, and this test dose is made as 3.6g crude drug/kg/d, is 40 times of clinical medicine dose.
1.4 animal used as test
The NIH mouse, the SPF level provides (SCXK (Guangdong) 2008-0002) by Guangdong Medical Lab Animal Center, normally raises and supplies examination after 3 days.
2 experimental techniques
Get 75 of NIH mouse, male and female have concurrently, and body weight 18-22g is divided into 5 groups at random, i.e. blank group, Composite Salvia Dropping Pill group, the basic, normal, high dosed administration group of pseudo-ginseng capsule of red sage root.Each organize every day gastric infusion once, continuous 30 days, the blank group gave equivalent physiological saline; After the last administration 1 hour with the single 250ml wide-mouth bottle that soda lime is housed of putting into of mouse; Be coated with vaseline around the bottle cap,, observe the anoxia in mice death time to guarantee sealing.
3 results
Table 1. pseudo-ginseng capsule of red sage root is to the influence
of mouse normal pressure resisting oxygen lack
Annotate: compare * P＜0.05, * * P＜0.01 with control group
Table 1 is the result show: the basic, normal, high dosage of pseudo-ginseng capsule of red sage root all can obviously prolong the hypoxia-bearing capability of mouse under normal pressure, and effect is dose dependent.
4 conclusions
The pseudo-ginseng capsule of red sage root can significantly improve the hypoxia-bearing capability of body.
Two, the pseudo-ginseng capsule of red sage root influences microcirculation of mouse auricle
1 test material
1.1 main agents
1.2 medicine
Pseudo-ginseng capsule of red sage root medicinal extract: 2.56g crude drug/g, lot number: 20110225, the Dongguan City Asia Pharmaceutical Co., Ltd provides; Compound danshen dripping pills: specification: 27mg/ ball, Tianjin Tasly Pharmaceutical Co., Ltd, lot number: 100321.
1.3 test dose
Pseudo-ginseng capsule of red sage root clinical every day of consumption is 7.68g crude drug/d (1.28g crude drug/0.5g/ grain; A 2-3 grain; One day secondary), become body weight for humans in 60kg, average dosage is 0.128g crude drug/kg/d; Basic, normal, high three dose groups of this test mice are made as 1.28,2.56 respectively, 5.12g crude drug/kg/d, and above-mentioned dosage is 10,20,40 times (according to the weight) of clinical medicine dose; Compound danshen dripping pills clinical every day of consumption be 5.39g crude drug/d (0.1797g crude drug/27mg/ ball, one time 10, three times on the one); Become body weight for humans in 60kg; Average dosage is 0.090g crude drug/kg/d, and this test dose is made as 3.6g crude drug/kg/d, is 40 times of clinical medicine dose.
1.4 animal used as test
The NIH mouse, the SPF level provides (SCXK (Guangdong) 2008-0002) by Guangdong Medical Lab Animal Center, normally raises and supplies examination after 3 days.
2 experimental techniques
Get 60 of NIH mouse, body weight 1822g, male and female half and half are divided into 5 groups at random, i.e. blank group, compound danshen dripping pills positive controls, the basic, normal, high dosed administration group of pseudo-ginseng capsule of red sage root.Each organize every day gastric infusion once; Continuous 7 days; The blank group gives equivalent physiological saline, after the last administration, each treated animal is anaesthetized with lumbar injection yellow Jackets 30mg/kg in 1 hour, with medical rubber patch unhairing on auricle; Mouse ventrad is fixed on down on the mouse observation platform, and the auricle surface drips a little atoleine.Observation platform is placed on the disecting microscope objective table; Under transmitted light; Observe and write down Mice Auricle arteriole, thin vein caliber earlier with 155 times of mirrors; And then drip one of 0.1% norepinephrine (NA), and observe its auricle arteriole, thin vein caliber again, more same position drips the variation of NA front and back auricular microcirculation capillary bore.
Table 2 pseudo-ginseng capsule of red sage root is to dripping the influence
of the thin artery and vein difference of NA front and back Mice Auricle
Annotate: compare with control group: * P＜0.05, * * P＜0.01
Visible from table 2, pseudo-ginseng capsule of red sage root high dose can alleviate the microcirculation disorder that the vessel retraction of inducing owing to NA causes, with the blank group significant difference is arranged relatively.
4, conclusion
The pseudo-ginseng capsule of red sage root has the microvascular effect of certain expansion, improves the body microcirculation.
Three, the pseudo-ginseng capsule of red sage root is to the influence of diet property hyperlipidemia rats blood lipid level
1 test material
1.1 main agents
201008), T-CHOL kit (lot number: 201011), HDL-C (HDL-C) kit (lot number: 201006), (lot number: 201004): Zhongsheng Beikong Biological Science & Technology Co., Ltd. produces LDL-C (LDL-C) kit triglycerides kit (lot number:.
1.2 medicine
Pseudo-ginseng capsule of red sage root medicinal extract: 2.56g crude drug/g, lot number: 20110225, the Dongguan City Asia Pharmaceutical Co., Ltd provides; Simvastatin: Mo Shadong pharmaceutical Co. Ltd in Hangzhou produces, lot number: 100495, and specification: 20mg/ sheet.
1.3 key instrument
DK-S26 type electric-heated thermostatic water bath (the accurate experimental facilities in Shanghai Co., Ltd); Low-temperature and high-speed centrifuge (Anting Scientific Instrument Factory, Shanghai, model TGL-16G); UV-1800 ultraviolet-visible spectrophotometer (Beijing Rayleigh is analyzed Co., Ltd).
1.4 animal used as test
The SD rat, the SPF level provides (SCXK (Guangdong) 2008-0002) by Guangdong Medical Lab Animal Center, raises in advance and supplies examination after 3 days.
1.5 feed
1.5.1 basal feed: Guangdong Medical Lab Animal Center provides.
1.5.2 high lipid food: press basal feed 86.7%, lard 10%, cholesterol 3%, cholate 0.2%, propylthiouracil (PTU) 0.1% standard, entrust Guangdong Medical Lab Animal Center to be processed into.
1.6 test dose
Pseudo-ginseng capsule of red sage root clinical every day of consumption is 7.68g crude drug/d (1.28g crude drug/0.5g/ grain.A 2-3 grain, one day secondary), become body weight for humans in 60kg, average dosage is 0.128g crude drug/kg/d.Basic, normal, high three dose groups of this test rat are made as 0.64,1.28 respectively, 2.56g crude drug/kg, and above-mentioned dosage is 5,10,20 times (according to the weight) of clinical medicine dose; Simvastatin: the 20mg/ sheet, every day 1 time, promptly 0.02g/ day/people becomes body weight for humans in 60kg, and average dosage is 0.333mg/kg/ day, and this test rat dosage is designed to 0.004g/kg.This dosage is 12 times (according to the weight) of clinical medicine dose.
2 experimental techniques
2.1 animal divides into groups and model is set up
Get 60 of SD rats; Body weight 180-220g; Male and female half and half are divided into normal control group, model control group, Simvastatin positive drug control group and the basic, normal, high dose groups of pseudo-ginseng capsule of red sage root (0.64,1.28,2.56g crude drug/kg body weight), 10 every group at random by body weight.From the experiment beginning; Model control group, Simvastatin positive drug control group and three dose groups of pseudo-ginseng capsule of red sage root; Every animal such as gives every day at capacity high lipid food feed, and the normal control group gives basal feed in the same manner, and the feed administered dose is identical with high lipid food.Respectively organize simultaneously the medicine filling stomach that rat gives corresponding dosage; The administration volume is 10ml/kg; Normal control group, model control group give equivalent physiological saline, successive administration 30 days, and 1h after the last administration (water 12h is can't help in fasting before the experiment) gets blood from rat eye socket veniplex; Centrifugal, separation of serum are measured TC, TG, HDL-C, LDL-C respectively.
2.2 blood fat and index of correlation are measured
Serum total cholesterol (TC) is measured, and adopts the oxidation enzyme process; Triglycerides (TG) is measured and is adopted the phosphoglycerol enzymic colorimetric; HDL-C (HDL-C) is measured the phosphotungstic acid-magnesium precipitate method that adopts; LDL-C (LDL-C) adopts the polyvinyl sulfuric acid precipitation method.
3 results
Table 3 is the result show; Compare with the normal control group, the cholesterol of model control group (TC), triglycerides (TG), low-density lipoprotein (LDL-C) level obviously raise, and HDL (HDL-C) level obviously reduces; Have significant difference (P＜0.01), the modeling success is described.Pseudo-ginseng capsule of red sage root high dose can significantly reduce TC, TG, LDL-C, rising HDL-C (P＜0.05).
Table 3 pseudo-ginseng capsule of red sage root is to the influence
of diet property hyperlipidemia rats blood lipid level
Annotate: with normal control group comparison ▲ p＜0.05, ▲ ▲ p＜0.01; Compare * p＜0.05, * * p＜0.01 with model control group
4 conclusions
The pseudo-ginseng capsule of red sage root can reduce serum TC, TG, LDL-C, and rising HDL-C has certain effect for reducing fat.
Four, the pseudo-ginseng capsule of red sage root is to the hemorheological influence of diet property hyperlipidemia rats
1 test material
1.1 medicine
Pseudo-ginseng capsule of red sage root medicinal extract: 2.56g crude drug/g, lot number: 20110225, the Dongguan City Asia Pharmaceutical Co., Ltd provides; Simvastatin: Hangzhou Mo Shadong pharmaceutical Co. Ltd.Lot number: 100495, specification: 20mg/ sheet.
1.2 key instrument
LGR-80A type fully automatic blood flow graph (in Beijing diligent generation Supreme Being's scientific instrument Co., Ltd).
1.3 animal used as test
The SD rat, the SPF level provides (SCXK (Guangdong) 2008-0002) by Guangdong Medical Lab Animal Center, raises in advance and supplies examination after 3 days.
1.4 feed
1.4.1 basal feed: Guangdong Medical Lab Animal Center provides.
1.4.2 high lipid food: press basal feed 86.7%, lard 10%, cholesterol 3%, cholate 0.2%, propylthiouracil (PTU) 0.1% standard, entrust Guangdong Medical Lab Animal Center to be processed into.
1.5 test dose
Pseudo-ginseng capsule of red sage root clinical every day of consumption is 7.68g crude drug/d (1.28g crude drug/0.5g/ grain.A 2-3 grain, one day secondary), become body weight for humans in 60kg, average dosage is 0.128g crude drug/kg/d.Basic, normal, high three dose groups of this test rat are made as 0.64,1.28 respectively, 2.56g crude drug/kg, and above-mentioned dosage is 5,10,20 times (according to the weight) of clinical medicine dose; Simvastatin: the 20mg/ sheet, every day 1 time, promptly 0.02g/ day/people becomes body weight for humans in 60kg, and average dosage is 0.333mg/kg/ day, and this test rat dosage is designed to 0.004g/kg.This dosage is 12 times (according to the weight) of clinical medicine dose.
2 experimental techniques
Get 60 of SD rats; Body weight 180-220g; Male and female half and half are divided into normal control group, model control group, Simvastatin positive drug control group and the basic, normal, high dose groups of pseudo-ginseng capsule of red sage root (0.64,1.28,2.56g crude drug/kg body weight), 10 every group at random by body weight.From the experiment beginning; Model control group, Simvastatin positive drug control group and three dose groups of pseudo-ginseng capsule of red sage root; Every animal such as gives every day at capacity high lipid food feed, and the normal control group gives basal feed in the same manner, and the feed administered dose is identical with high lipid food.Respectively organize simultaneously the medicine filling stomach that rat gives corresponding dosage, the administration volume is 10ml/kg, and normal control group, model control group give equivalent physiological saline; Successive administration 30 days, 1h after the last administration (water 12h is can't help in fasting before the experiment), each organizes rats by intraperitoneal injection yellow Jackets 45mg/kg anesthesia; The arteria carotis communis intubate is got blood 4ml, puts into the test tube of handling with heparin in advance, gently vibration; Shake up, in 4h, survey hemorheological indexes with the fully automatic blood flow graph.
3 results
Table 4 is the result show: compare with model control group, pseudo-ginseng capsule of red sage root high dose group can reduce high, medium and low viscosity and the blood plasma viscosity cut of hyperlipidemia rats whole blood.
Table 4 pseudo-ginseng capsule of red sage root is to the hemorheological influence of diet property
Annotate: compare with the normal control group
▲P＜0.05,
▲ ▲P＜0.01; Compare * P＜0.05, * * P＜0.01 with model control group
4. conclusion
The pseudo-ginseng capsule of red sage root can reduce the viscosity of hyperlipidemia rats blood, and it is unusual to improve Hemorheology.
Five, the pseudo-ginseng capsule of red sage root is to the influence of diet property hyperlipidemia rats antioxidation
1 test material
1.1 main agents
Superoxide dismutase (SOD) testing cassete (bio-engineering research institute, lot number 20110331 are built up in Nanjing); MDA (MDA) is measured kit (bio-engineering research institute, lot number 20110339 are built up in Nanjing).
1.2 medicine
Pseudo-ginseng capsule of red sage root medicinal extract: 2.56g crude drug/g, lot number: 20110225, the Dongguan City Asia Pharmaceutical Co., Ltd provides; Simvastatin, Hangzhou Mo Shadong pharmaceutical Co. Ltd, lot number: 100495, specification: 20mg/ sheet.
1.3 key instrument
DK-S26 type electric-heated thermostatic water bath (the accurate experimental facilities in Shanghai Co., Ltd); Low-temperature and high-speed centrifuge (Anting Scientific Instrument Factory, Shanghai, model TGL-16G); UV-1800 ultraviolet-visible spectrophotometer (Beijing Rayleigh is analyzed Co., Ltd).
1.4 animal used as test
The SD rat, the SPF level provides (SCXK (Guangdong) 2008-0002) by Guangdong Medical Lab Animal Center, raises in advance and supplies examination after 3 days.
1.4 feed:
1.4.1 basal feed: Guangdong Medical Lab Animal Center provides.
1.4.2 high lipid food: press basal feed 86.7%, lard 10%, cholesterol 3%, cholate 0.2%, propylthiouracil (PTU) 0.1% standard, entrust Guangdong Medical Lab Animal Center to be processed into.
1.5 test dose
Pseudo-ginseng capsule of red sage root clinical every day of consumption is 7.68g crude drug/d (1.28g crude drug/0.5g/ grain.A 2-3 grain, one day secondary), become body weight for humans in 60kg, average dosage is 0.128g crude drug/kg/d.Basic, normal, high three dose groups of this test rat are made as 0.64,1.28 respectively, 2.56g crude drug/kg, and above-mentioned dosage is 5,10,20 times (according to the weight) of clinical medicine dose; Simvastatin: the 20mg/ sheet, every day 1 time, promptly 0.02g/ day/people becomes body weight for humans in 60kg, and average dosage is 0.333mg/kg/ day, and this test rat dosage is designed to 0.004g/kg.This dosage is 12 times (according to the weight) of clinical medicine dose.
2 experimental techniques
Get 60 of SD rats; Body weight 180-220g; Male and female half and half are divided into normal control group, model control group, Simvastatin positive drug control group and the basic, normal, high dose groups of pseudo-ginseng capsule of red sage root (0.64,1.28,2.56, g crude drug/kg body weight), 10 every group at random by body weight.From the experiment beginning; Model control group, Simvastatin positive drug control group and three dose groups of pseudo-ginseng capsule of red sage root; Every animal such as gives every day at capacity high lipid food feed, and the normal control group gives basal feed in the same manner, and the feed administered dose is identical with high lipid food.Respectively organize simultaneously the medicine filling stomach that rat gives corresponding dosage; The administration volume is 10ml/kg; Normal control group, model control group give equivalent physiological saline, successive administration 30 days, and 1h after the last administration (water 12h is can't help in fasting before the experiment) gets blood from rat eye socket veniplex; Centrifugal, separation of serum are measured superoxide dismutase (SOD), MDA (MDA) respectively.
3 results
Table 5 is the result show: compare with the normal control group, model control group SOD is active obviously to be reduced, and the MDA value is rising (p＜0.05) obviously.The middle and high dose groups of pseudo-ginseng capsule of red sage root can significantly reduce MDA value (p＜0.05 or p＜0.01), but high dose group increased SOD active (p＜0.05).
Table 5 pseudo-ginseng capsule of red sage root is to the influence
of diet property hyperlipidemia rats SOD and MDA
Annotate: compare with the normal control group
▲P＜0.05,
▲ ▲P＜0.01; Compare * p＜0.05, * * p＜0.01 with model control group
4 conclusions
The pseudo-ginseng capsule of red sage root can improve the activity of superoxide dismutase in the body, reduces MDA and produces.Has tangible antioxidation.
Six, the pseudo-ginseng capsule of red sage root is to the influence of STZ blood glucose in diabetic mice
1 test material
1.1 main agents
Blood sugar test paper: Taiwan Houmeide Biological Sci-Tech Co., Ltd., lot number HA0B171; Glucose assays kit: Zhongsheng Beikong Biological Science & Technology Co., Ltd., lot number: 112561; Streptozotocin (STZ): sigma company.
1.2 medicine
Pseudo-ginseng capsule of red sage root medicinal extract: 2.56g crude drug/g, lot number: 20110225, the Dongguan City Asia Pharmaceutical Co., Ltd provides; Glibenclamide: specification: 2.5mg/ sheet, Tianjin Pacific Pharmaceutical Co., Ltd., lot number: 080707.
1.3 test dose
Pseudo-ginseng capsule of red sage root clinical every day of consumption is 7.68g crude drug/d (1.28g crude drug/0.5g/ grain; A 2-3 grain; One day secondary), become body weight for humans in 60kg, average dosage is 0.128g crude drug/kg/d; Basic, normal, high three dose groups of this test mice are made as 1.28,2.56 respectively, 5.12g crude drug/kg/d, and above-mentioned dosage is 10,20,40 times (according to the weight) of clinical medicine dose; Glibenclamide clinical every day of consumption is 10mg/kg/ day (each 2,2 times/day), becomes body weight for humans in 60kg, and average dosage is 0.16667mg/kg/d, and this test mice dosage is designed to 2mg/kg/d.This dosage is 12 times (according to the weight) of clinical medicine dose.
1.4 animal used as test
The NIH mouse, the SP level provides (SCXK (Guangdong) 2008-0002) by Guangdong Medical Lab Animal Center, normally raises and supplies examination after 3 days.
1.5 key instrument
DK-S26 type electric-heated thermostatic water bath (the accurate experimental facilities in Shanghai Co., Ltd); Low-temperature and high-speed centrifuge (Anting Scientific Instrument Factory, Shanghai, model TGL-16G); UV-1800 ultraviolet-visible spectrophotometer (Beijing Rayleigh is analyzed Co., Ltd).
2 experimental techniques
Get 110 NIH kind mouse, body weight 19～22g, the male and female dual-purpose is got 15 as the normal control group earlier at random, and all the other are as model control group.Behind the mouse fasting 12h, (STZ is prepared by the citric acid buffer salt model control group lumbar injection Streptozotocin; PH value is 4.4, faces and uses preceding preparation) 160mg/kg, normal control group lumbar injection citrate buffer solution; Behind the 72h, mouse fasting 12h gets blood with glass capillary eyeground vein clump; And measure fasting blood-glucose with blood sugar test paper, selecting the mouse of fasting blood-glucose >=11.1mmol/L is diabetic mice, model mice is divided into 5 groups more at random: model control group; Model+high, medium and low the dose groups of pseudo-ginseng capsule of red sage root, model+glibenclamide positive drug control group, 15 every group.Each treated animal gastric infusion, every day 1 time, continuous 30 days, normal and model control group gave equivalent physiological saline, after the last administration, mouse fasting 12h, eye socket is got blood, uses determination of glucose oxidase blood sugar.
3 results
Table 6 is the result show: pseudo-ginseng capsule of red sage root high dose group can obviously reduce STZ blood glucose in diabetic mice level, and relatively there were significant differences (P＜0.05) with model control group.
Table 6. pseudo-ginseng capsule of red sage root is to the influence
of STZ blood glucose in diabetic mice
Annotate: compare with the normal control group
▲P＜0.05,
▲ ▲P＜0.01; Compare * P＜0.05, * * P＜0.01 with model control group
4 conclusions
The pseudo-ginseng capsule of red sage root has certain hypoglycemic activity to diabetic mice.
Seven, brief summary
1. but time-to-live of the anti-anoxic of pseudo-ginseng capsule of red sage root significant prolongation mouse, improve the hypoxia-bearing capability of body.
2. the pseudo-ginseng capsule of red sage root has some improvement to the microcirculation disorder of body.
3. through observing of the influence of pseudo-ginseng capsule of red sage root to experimental hyperlipemia rat model; The result shows that high dose pseudo-ginseng capsule of red sage root can reduce hyperlipemia rat fat level, shows that the pseudo-ginseng capsule of red sage root has certain adjusting blood fat to experimental hyperlipemia rat.
4. the pseudo-ginseng capsule of red sage root can obviously reduce high, medium and low viscosity, the blood plasma viscosity cut of diet property hyperlipidemia rats whole blood, alleviates the hyperlipidemia rats blood viscosity.It is unusual to point out this medicine can to a certain degree improve the Hemorheology that hyperlipidemia causes.
5, the pseudo-ginseng capsule of red sage root can significantly improve serum superoxide dismutases (SOD) vigor, reduces serum lipid peroxide MDA (MDA) content, increases the ability that body is removed oxygen radical, has tangible lipoid peroxidization resistant.
6, the pseudo-ginseng capsule of red sage root has certain hypoglycemic activity to diabetic mice.
Health composition of the present invention shows through Guangdong Pharmaceutical University's pharmacodynamic study: can reduce the viscosity of hyperlipidemia rats blood, it is unusual to improve Hemorheology, improves the body microcirculation; Can significantly improve the hypoxia-bearing capability of body; Tangible antioxidation is arranged; Certain effect for reducing blood fat and certain hypoglycemic activity are arranged.For improving blood circulation, improving anoxia endurance, auxiliary antilipemic, anti-oxidant, pseudo-ginseng, the red sage root, gynostemma pentaphylla three flavors are worked in coordination with each other, are cooperatively interacted in the prescription.Pseudo-ginseng, the red sage root, gynostemma pentaphylla have all been included in " Ministry of Public Health is about the notice of the further standard healthy food material management " annex 2 " the article list that can be used for health food " on October 27th, 2002, and be quite safe to human body.
Health composition of the present invention can be used for the elderly and the part a middle-aged person daily health caring to cardiovascular and cerebrovascular, also can be used as cardiovascular and cerebrovascular patient's treatment supplement.
Composition of the present invention can be processed ordinary preparation, also can be sustained release preparation, controlled release preparation, targeting preparation and various particulate delivery system.
For the unit form of administration is processed tablet, various carrier well known in the art can be widely used.Example about carrier is, like diluent and absorbent: starch, dextrin, calcium sulfate, lactose, sweet mellow wine, sucrose, sodium chloride, glucose, urea, calcium carbonate, white bole, microcrystalline cellulose, alumina silicate etc.; Wetting agent and adhesive: water, glycerine, polyethylene glycol, ethanol, propyl alcohol, starch slurry, dextrin, syrup, honey, glucose solution, mucialga of arabic gummy, gelatine size, sodium carboxymethylcellulose, lac, methylcellulose, potassium phosphate, polyvinylpyrrolidone etc.; Disintegrant, for example dry starch, alginate, agar powder, laminaran, sodium acid carbonate and citric acid, calcium carbonate, polyoxyethylene sorbitol fatty acid ester, dodecyl sodium sulfate, methylcellulose, ethyl cellulose etc.; The disintegration inhibitor is like sucrose, glyceryl tristearate, cocoa butter, ammonification wet goods; Sorbefacient, for example quaternary ammonium salt, lauryl sodium sulfate etc.; Lubricant, for example talcum powder, silica, cornstarch, stearate, boric acid, atoleine, polyethylene glycol etc.; Can also tablet further be processed coating tablet, for example sugar coated tablet, thin membrane coated tablet, ECT, or double-layer tablet and multilayer tablet.
Process pill for the administration unit, various carrier well known in the art can be widely used.Example about carrier is, for example diluent and absorbent are like glucose, lactose, starch, cocoa butter, hydrogenated vegetable oil, polyvinylpyrrolidone, Gelucire, kaolin, talcum powder etc.; Adhesive is like Arabic gum, bassora gum, gelatin, ethanol, honey, liquid sugar, rice paste or batter etc.; Disintegrant is like agar powder, dry starch, alginate, dodecyl sodium sulfate, methylcellulose, ethyl cellulose etc.
For capsule is processed in the administration unit; Active ingredient is mixed with above-mentioned various carriers; And the mixture that will obtain thus places hard gelatine capsule or soft capsule; Also can active ingredient be processed microcapsules, be suspended in and form supensoid agent in the aqueous medium, in the hard shell capsules of also can packing into or process injection and use.
For example composition of the present invention is processed injection preparation; Like solution, supensoid agent solution, emulsion, freeze drying powder injection; This preparation can be moisture or non-water; Can contain acceptable carrier, diluent, adhesive, lubricant, anticorrisive agent, surfactant or dispersant on a kind of and/or multiple pharmacodynamics; Can be selected from water, ethanol, polyethylene glycol, 1 like diluent, the isooctadecanol of ammediol, ethoxylation, the isooctadecanol of polyoxyization, Polyoxyethylene Sorbitol Fatty Acid Esters etc.In addition, ooze parenteral solution, can in injection preparation, add proper amount of sodium chloride, glucose or glycerine, in addition, can also add conventional cosolvent, buffer, pH conditioning agent etc. in order to prepare etc.These auxiliary materials are that this area is commonly used.
In addition, like needs, also can in pharmaceutical preparation, add colouring agent, anticorrisive agent, spices, flavouring, sweetener or other materials.
Last institute should be noted that; Above embodiment is only in order to technical scheme of the present invention to be described but not to the restriction of protection domain of the present invention; Although the present invention has been done detailed description with reference to preferred embodiment; Those of ordinary skill in the art should be appreciated that and can make amendment or be equal to replacement technical scheme of the present invention, and do not break away from the essence and the scope of technical scheme of the present invention.
Claims (5)
1. a health composition is characterized in that, said health composition is processed by the raw material of following parts by weight: 2～10 parts of the reds sage root, 1～8 part of pseudo-ginseng, 2～10 parts of gynostemma pentaphylla.
2. health composition according to claim 1 is characterized in that, said health composition is processed by the raw material of following parts by weight: 3.43 parts of the reds sage root, 1 part of pseudo-ginseng, 2.84 parts of gynostemma pentaphylla.
One kind be used to improve blood circulation, improve anoxia endurance, the preparation method of the health composition of auxiliary antilipemic, anti-oxidant and auxiliary hyperglycemic, it is characterized in that it comprises the following steps:
A, press column weight amount umber and take by weighing raw material: 2～10 parts of the reds sage root, 1～8 part of pseudo-ginseng, 2～10 parts of gynostemma pentaphylla;
B, get the red sage root with 30～97% alcohol extract 1～3 time, each 0.5～3 hour, filter, merging filtrate, reclaim ethanol after soup subsequent use; Dregs of a decoction water extracts 1～2 time, and each 0.5～3 hour, filter, filtrating and above-mentioned combining medicine concentrate, and drying is ground into fine powder;
C, get pseudo-ginseng, be ground into fine powder, cross 30～600 orders;
D, get the gynostemma pentaphylla water and extract 1～3 time, each 1～3 hour, filter; Be concentrated to relative density be 1.05～1.5, said relative density is 60 ℃ of mensuration, adds ethanol and reaches 30～80% to containing the alcohol amount; Stir, left standstill 1～72 hour, filter; Filtrate recycling ethanol, concentrated, dry, be ground into fine powder;
E, above-mentioned three kinds of fine powders are mixed process preparation.
4. health composition according to claim 1 as be used to improve blood circulation, improve anoxia endurance, the purposes of the health food of auxiliary antilipemic, anti-oxidant and auxiliary hyperglycemic.
5. health composition according to claim 3 as be used to improve blood circulation, improve anoxia endurance, the purposes of the health food of auxiliary antilipemic, anti-oxidant and auxiliary hyperglycemic; It is characterized in that said health food is capsule, tablet, granule, pill, pill, lozenge, mixture, oral solution, powder, soft extract, syrup.
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Effective date of registration: 20210324 Address after: 523000 Building 1, 9 Hongmei Avenue, Hongmei Town, Dongguan City, Guangdong Province Patentee after: Dongguan Asia Pharmaceutical Technology Co.,Ltd. Address before: 523160 Guangdong city of Dongguan Province Hong Mei Town Yingbin Avenue Patentee before: DONGGUAN ASIA PHARMACEUTICAL Co.,Ltd. |