CN104997821A - Use of Radix Peucedani extract in immune function improvement - Google Patents
Use of Radix Peucedani extract in immune function improvement Download PDFInfo
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Abstract
The invention relates to a use of Radix Peucedani extract in immune function improvement, concretely relates to a use of Radix Peucedani extract especially Radix Peucedani aqueous extract or Radix Peucedani volatile oil in the preparation of medicines for improving immune functions especially nonspecific immune functions, and further relates to a medicinal composition containing the Radix Peucedani extract, and a health product containing the Radix Peucedani extract.
Description
Technical field
The present invention relates to Radix Peucedani extract for the preparation of the purposes improved in the medicine of immunologic function, described Radix Peucedani extract refers in particular to Radix Peucedani water extract or Radix Peucedani volatile oil, and described immunologic function refers in particular to non-specific immunity.The invention further relates to the pharmaceutical composition containing Radix Peucedani extract and health product.
Background technology
Immunity is that body immune system identification " is controlled oneself " and " non-", removes antigen foreign body, to maintain the protectiveness physiological reaction of body internal and external environment balance and stability by immunne response.The immune system of human body comprises organ: bone marrow, thymus, spleen, lymph node, tonsil; Cell: lymphocyte, phagocyte; And body fluid: various antibody and lymphokine.The immunity of body comprises nonspecific immunity and specific immunity.Specific immunity is that body will be formed the day after tomorrow, the defense function usually only worked to a certain special pathogen or foreign body.Nonspecific immunity is the natural immunity, is the natural protection function that body is set up gradually in long-term germline development and evolutionary process.Nonspecific immunity is the 1st, 2 defence lines, road of human body.Form the antibiotic substance in the organic physiologic barrier of material base of nonspecific immunity, cytophagous phagocytosis and normal body fluid and tissue.Wherein phagocyte is the important substance forming human body non-specific immunity, and the size of its phagocytic activity directly has influence on the power of the non-specific immunity of human body.Macrophage is very important a kind of cell in phagocyte, and it not only has phagocytic activity also can secrete multiple soluble factor, not only has and strengthens the effect that sterilization promotes inflammation, also have the critical functions such as immunomodulating.
The power of non-specific immunity directly has influence on body and resists the ability of extraneous harmful substance as antibacterial, virus, the low of immunologic function will cause body be subject to the infection of various pathogenic bacteria and therefore suffer from various disease, therefore, raising immunologic function particularly non-specific immunity contributes to improving immunity of organisms, thus better resists the invasion of foreign substance.
Radix Peucedani is the root of Umbelliferae herbaceos perennial Peucedanum praeruptorum DUNN Peucedanum praeruptorumDunn or RADIX PEUCEDANI Peucedanum decursivum (Miq.) Maximde, main product in Zhejiang, Hunan, Anhui, the ground such as Jiangxi.Its bitter in the mouth, pungent, be slightly cold, there is effect of wind and heat dispersing, lowering the adverse-rising QI to resolve phlegm.At present, the effect for Radix Peucedani extract has many sections of reports, as people such as " Lanzhou University's journal: medicine " Liang Jiandi, the 4th phase in 2012, discloses the antitussive effect of few mao of northern Radix Peucedani water extract; The people such as " Chinese pharmacists " Tu Xin, the 3rd phase in 2004, disclose the impact of Peucedanum praeruptorum DUNN extract on middle cerebral artery infarction rat IL-6 and IL-8; The people such as " Chinese Medical Sciences University's journal " Liu Xiaoyang, the 4th phase in 2002, disclose the impact of Peucedanum praeruptorum DUNN water-alcohol extraction on ischemia-reperfusion rat blood serum IL-6 level; The people such as " Chinese Medical Sciences University's journal " Wang Qiuyue, phase calendar year 2001 the 1st, disclose the impact of Peucedanum praeruptorum DUNN extract on hypoxic pulmonary hypertension patient endothelin level-1; " Chinese Medical Sciences University's journal " is healthy waits people, the 2nd phase in 1993, discloses the diastole effect of Peucedanum praeruptorum DUNN ligroin extraction to people's isolated pulmonary artery ring; The people such as " research and development of natural products " Liu Yaman, o. 11th in 2012, discloses the choline esterase inhibition of Radix Peucedani volatile oil, etc.But Radix Peucedani extract there is not yet any report for the effect of immune function of human body.
Chinese medicine have draw materials natural, effect steadily, the little particular advantages waiting Western medicine incomparable of toxic and side effects, along with the progress of society, the development of the productivity, people more and more pursue good health and a long life, and modern more and more turns to crude drug attention from chemical combination patent medicine, wish from crude drug, to develop safer effective new drug to substitute the former, thus reduce the generation of medicine source disease.The present invention utilizes gentle Chinese medicine extract, and Radix Peucedani extract reaches and improves immune function of human body, and improve human body immunity, constitutional effect, will have good application prospect.
Summary of the invention
The object of this invention is to provide the purposes that Radix Peucedani extract improves immunologic function, particularly by improving the phagocytic activity of macrophage, and then improving the non-specific immunity of human body, reaching the effect improving immune function of human body.
The invention provides Radix Peucedani extract for the preparation of the purposes improved in the medicine of immunologic function.
Radix Peucedani described herein refers to Peucedanum praeruptorum DUNN Peucedanum praeruptorum Dunn or RADIX PEUCEDANI Peucedanum decursivum (Miq.) Maximde.
Radix Peucedani extract described herein refers in particular to Radix Peucedani water extract or Radix Peucedani volatile oil, wherein Radix Peucedani water extract can pass through, by the appropriate water reflux, extract, of Radix Peucedani medical material, or obtain Radix Peucedani Aqueous extracts by reflux, extract, after appropriate water soaking, then drying under reduced pressure after Radix Peucedani Aqueous extracts alcohol precipitation is obtained; Wherein Radix Peucedani volatile oil can pass through, and the appropriate hydroecium temperature of Radix Peucedani medical material is extracted, or obtains with room temperature extraction after appropriate water soaking, the extractive of volatile oil beta cyclodextrin enclose obtained can be obtained end product especially.
Immunologic function described herein refers to non-specific immunity especially.
Another object of the present invention is to provide Radix Peucedani extract particularly Radix Peucedani water extract or the purposes of Radix Peucedani volatile oil in the medicine for the preparation of raising macrophages phagocytic capacity.
The present invention further provides a kind of pharmaceutical composition, it contains Radix Peucedani extract as the active component improving immunologic function, and pharmaceutically acceptable carrier; Described Radix Peucedani extract refers in particular to Radix Peucedani water extract or Radix Peucedani volatile oil, and described immunologic function refers in particular to non-specific immunity.
In aforementioned pharmaceutical compositions, the weight ratio shared by Radix Peucedani extract is 1% ~ 100%, is preferably 1% ~ 95%.
Aforementioned pharmaceutical compositions can contain Radix Peucedani extract as the sole active agent improving immunologic function, and pharmaceutically acceptable carrier.
Aforementioned pharmaceutical compositions can also improve the active component of immunologic function containing other except Radix Peucedani extract, other active component described can be natural product or synthetic product, and itself and Radix Peucedani extract coupling better can be improved the effect of immunologic function.
The present invention also provides aforementioned pharmaceutical compositions for the preparation of the purposes improved in the medicine of immunologic function, and described immunologic function refers in particular to non-specific immunity.
The present invention separately provides the purposes of aforementioned pharmaceutical compositions in the medicine for the preparation of raising macrophages phagocytic capacity.
Of the present inventionly provide a kind of health product further, it comprises Radix Peucedani extract as the upper acceptable additive of active component and threpsology improving immunologic function; Wherein said Radix Peucedani extract refers in particular to Radix Peucedani water extract or Radix Peucedani volatile oil, and described immunologic function refers in particular to non-specific immunity.
In above-mentioned health product, the weight ratio shared by Radix Peucedani extract is 1% ~ 100%, is preferably 40% ~ 100%.
The following detailed description of the present invention.
Radix Peucedani water extract of the present invention can be prepared by following method in detail.
Get Radix Peucedani medical material in container, add water appropriate, reflux, extract, obtains Radix Peucedani Aqueous extracts, and by Radix Peucedani Aqueous extracts with after alcohol precipitation, in vacuum tank, drying under reduced pressure obtains final Radix Peucedani water extract.
Radix Peucedani volatile oil of the present invention can be prepared by following method in detail.
Get Radix Peucedani medical material in container, add water appropriate, obtain Radix Peucedani extractive of volatile oil, use beta cyclodextrin enclose further especially.
Term " immunologic function " refers to body immune system identification self and dissident's material, and gets rid of antigenicity foreign body by immunne response, to maintain the function of organism physiology balance.Immunologic function is a kind of physiological function of human body, human body relies on this identification of function " oneself " and " non-own " composition, thus destroy and repel and enter the antigenic substance of human body, or the damaging cells that produces of human body itself and tumor cell etc., to maintain the health of human body.The immunologic function of body comprises specific immune function and non-specific immunity.
Term " non-specific immunity " refers to the natural immunity, is the natural protection function that body is set up gradually in long-term germline development and evolutionary process.Non-specific immune systems comprises tissue barrier (skin and mucosal system, blood brain barrier, placental barrier etc.); Inherent immunity cell (phagocyte, killer cell, dendritic cell etc.); Inherent immunity molecule (complement, cytokine, enzyme material etc.).
Described macrophage is the composing factor of non-specific immune systems, its phagocytic activity is one of important indicator weighing body non-specific immunity, the size of macrophage Carbon clearance index K and phagocytic index α can reflect the power of endothelium reticular system phagocytic function, after the antigenicity substance such as antibacterial, foreign body enters body, can rapidly by macrophage phagocytic and removing.
Pharmaceutical composition of the present invention can comprise conventional carrier known in the art, adjuvant or diluent, described carrier, adjuvant or diluent, such as, lactose, glucose, sucrose, sorbitol, mannitol, xylitol, erythroglucin, maltose alcohol, starch, acacia gum, alginate, gelatin, calcium phosphate, calcium silicates, cellulose, methylcellulose, polyvinylpyrrolidone, water, hydroxymethyl-benzoic acid, hydroxypropyl benzoic acid, Pulvis Talci, magnesium stearate and mineral oil, but be not limited thereto.These preparations can comprise filler, anticoagulant, lubricant, wetting agent, flavoring agent, emulsifying agent, antiseptic etc. in addition.Compositions of the present invention can be made by utilizing any known method in this area, can provide active component that is quick, lasting or slow releasing after making patient's medication.
Such as, compositions of the present invention can be dissolved in oil, propyleneglycoles or other be generally used for preparing in the solvent of injection, the Examples of carriers be applicable to comprises normal saline, polyethylene glycol, ethanol, vegetable oil, isopropyl myristate etc., but is not limited to them.As Epidermal administration, extract of the present invention can also be made into ointment and emulsifiable paste.
The pharmaceutical preparation comprising the present composition can be prepared in any form, as peroral dosage form (powder, tablet, capsule, soft capsule, liquid medicine, syrup, wine made of broomcorn millet ball, powder, wafer, granule), or epidermis preparation (emulsifiable paste, ointment, lotion, gel, face cream, plaster, paste, spray, aerosol etc.), or ejection preparation (solution, suspending agent, Emulsion).
Compositions of the present invention can be used alone or also can with other pharmaceutically activated compound conbined usage.
The dosage of extract of the present invention or compositions is different from the difference of the order of severity of the situation of individuality and weight, the state of an illness, medicament forms, route of administration and dosage period, and it also can be selected by those skilled in the art.But, in order to obtain desirable effect, to invention extract of the present invention, usually suggestion dosage scope by weight/sky is calculated as 0.1 to 1000 mg/kg, is preferably 1 to 100 mg/kg.Dosage can be single-dose or the every day of administration several times every day.
Pharmaceutical composition in the present invention can be administered to individual animals by all means as mammal (rat, mice, domesticate animals or the mankind), described administering mode can be such as, oral, rectally or in vein, intramuscular, subcutaneous, Intradermal, sheath, epidural or intracerebral ventricle injection.
Another object of the present invention is to provide a kind of functional health food comprising Radix Peucedani extract.
Term " functional health food " is herein defined as " by adding extract of the present invention in conventional food, strengthening the functional food of function as body function or physiological function, to improve body's immunity ".
Another object of the present invention is to provide a kind of health product comprising extract of the present invention, and the upper acceptable additive of threpsology, to improve body's immunity.
Term " health food " is herein defined as " comprise the food of extract of the present invention; described food does not have specific predictive role but has general predictive role; can with it on a small quantity as additive, or using full dose as capsule, the form of granule, tablet etc. ".
Term " the upper acceptable additive of threpsology " is herein defined as " any material with desired use, described material will become or reasonably expect to become directly or indirectly the component of any food or otherwise can affect the feature of any food ", such as, thickening agent, maturing agent, bleach, sequestering agent, wetting agent, anticoagulant, clarifier, food processing agent, emulsifying agent, stabilizing agent, concentrating agents, alkali and acid, foaming agent, nutrient, coloring agent, flavoring agent, sweeting agent, antiseptic, antioxidant etc., its material be known in the art.
If a kind of material is added in food for specific purposes, it can be called direct additive and indirect food additive, and these additives become a part for food with micro-consumption due to packaging, storage or other process.
Above-mentioned health food can be contained in food, in healthy beverage, in dietotherapy etc., and its powder, granule, tablet, chewable tablet, capsule, beverage etc. form can be used for prevention or improve target disease.
Extract of the present invention can also be added in food or beverage for preventing and improving target disease.As functional health food or health product, the quantity of extract of the present invention in food or beverage is generally the scope of about 0.01 to 15w/w% of the food gross weight as functional health food component.Especially, although extract of the present invention preferable amount in functional health food, health food or food of special nutrients changes according to the expection object difference of each food, in general invention extract of the present invention be preferably used as the consumption of additive in food (as noodles etc.) be about 0.01 to 5% scope, in health food, be expressed as the scope of 40 to 100% with the ratio of the food component of 100%.
As long as the healthy beverage compositions in the present invention comprises the extract of the present invention as basis in shown ratio, so other liquid component is then had no particular limits, wherein other composition can be various deodorizer or natural magnesium etc., as the beverage of routine.The example of above-mentioned natural magnesium is that monosaccharide is as glucose, fructose etc.; Disaccharidase is as maltose, sucrose etc.; Conventional sugar is as dextrin, cyclodextrin; And sugar alcohol is as xylitol and erythroglucin etc.Except other deodorizer except the above-mentioned deodorizer mentioned, also has as sweet in rope, the Stevia rebaudiana (Bertoni) Hemsl extract of natural deodorant as Radix Angelicae Sinensis Saponin A, glycyrrhizic acid etc., with synthesis deodorizer as glucide, aspartame etc., perhaps these deodorizer advantageously use.The consumption of above-mentioned natural magnesium is generally in the ratio of the beverage composition for treating dental erosion of the present invention of 100 milliliters and is about 1 to 20 gram, is preferably the scope of 5 to 12 grams.
Other component except compositions mentioned above is the improvers such as various nutrient, vitamin, mineral or electrolyte, synthesis flavoring agent, coloring agent and cheese chocolate; pectic acid and salt thereof; algae ortho acid and salt thereof; organic acid; protective colloid sticker, carburization agent in pH adjusting agent, stabilizing agent, antiseptic, alcohol, soda pop etc.Other component except component mentioned above also has the fruice for the preparation of natural fruit juice, fruit drink and vegetable beverage, and component wherein can be used alone or in combination.The ratio of described component is not so important, but the scope of about 0 to 20w/w% in general every 100w/w% present composition.Here the example comprising the addible food of said extracted thing mentioned is various food, beverage, chewing gum, vitamin complex, health improve food etc.
Those skilled in the art can find can carry out various modification and change when not departing from essence of the present invention or scope to compositions of the present invention, usage and goods.
Below will illustrate in greater detail the present invention by specific embodiment, but should be appreciated that in the present invention's where method in office and be not limited to these embodiments.
Detailed description of the invention
The present invention describes in detail by following embodiment, but it should be understood that the present invention is not limited to these embodiments.
Following preparation embodiment, experimental example are to prove the present invention further, but are not limited to its scope.
The experimental technique of unreceipted actual conditions in the embodiment of the present invention, usually conveniently condition, or according to the condition that raw material or commodity manufacturer advise.The reagent in unreceipted concrete source is the conventional reagent that market is bought.
Preparation embodiment 1: the preparation one of Radix Peucedani water extract
Get Radix Peucedani medical material (Peucedanum praeruptorum DUNN, purchased from Guangdong Feng Chun pharmaceutical Co. Ltd) 100g is in container, add the water of 8 times amount, reflux, extract, 6 hours, collect Aqueous extracts, obtain Radix Peucedani Aqueous extracts, by Radix Peucedani Aqueous extracts after alcohol settling, filter, the solid obtained drying under reduced pressure in vacuum tank is obtained Radix Peucedani water extract one.
Preparation embodiment 2: the preparation two of Radix Peucedani water extract
Get Radix Peucedani medical material 100g, add the water of 9 times amount, reflux, extract, 8 hours, collect Aqueous extracts, obtain Radix Peucedani Aqueous extracts.By Radix Peucedani Aqueous extracts after alcohol settling, filter, the solid obtained drying under reduced pressure in vacuum tank is obtained Radix Peucedani water extract two.
Preparation embodiment 3: the preparation three of Radix Peucedani water extract
Get Radix Peucedani medical material 100g, add the water of 10 times amount, reflux, extract, 10 hours, collect Aqueous extracts, obtain Radix Peucedani Aqueous extracts.By Radix Peucedani Aqueous extracts after alcohol settling, filter, the solid obtained drying under reduced pressure in vacuum tank is obtained Radix Peucedani water extract three.
Preparation embodiment 4: the preparation four of Radix Peucedani water extract
Get Radix Peucedani medical material 100g in container, add the water soaking of 8 times amount after 1 hour, reflux, extract, 6 hours, collect Aqueous extracts, obtain Radix Peucedani Aqueous extracts.By Radix Peucedani Aqueous extracts after alcohol settling, filter, the solid obtained drying under reduced pressure in vacuum tank is obtained Radix Peucedani water extract four.
Preparation embodiment 5: the preparation five of Radix Peucedani water extract
Get Radix Peucedani medical material 100g, add 9 times amount water soakings after 1 hour, reflux, extract, 8 hours, obtains Radix Peucedani Aqueous extracts.By Radix Peucedani Aqueous extracts after alcohol settling, filter, the solid obtained drying under reduced pressure in vacuum tank is obtained Radix Peucedani water extract five.
Preparation embodiment 6: the preparation six of Radix Peucedani water extract
Get Radix Peucedani medical material 100g, add 10 times amount water soakings after 1 hour, reflux, extract, 10 hours, obtains Radix Peucedani Aqueous extracts.By Radix Peucedani Aqueous extracts after alcohol settling, filter, the solid obtained drying under reduced pressure in vacuum tank is obtained Radix Peucedani water extract six.
Preparation embodiment 7: the preparation one of Radix Peucedani volatile oil
Get Radix Peucedani medical material 100g in container, add the water of 8 times amount, room temperature extracts 6 hours, collects volatile oil, obtains Radix Peucedani extractive of volatile oil one.
Preparation embodiment 8: the preparation two of Radix Peucedani volatile oil
Get Radix Peucedani medical material 100g, add the water of 9 times amount, room temperature extracts volatile oil 8 hours, collects volatile oil, obtains Radix Peucedani extractive of volatile oil two.
Preparation embodiment 9: the preparation three of Radix Peucedani volatile oil
Get Radix Peucedani medical material 100g, add the water of 10 times amount, room temperature extracts volatile oil 10 hours, collects volatile oil, obtains Radix Peucedani extractive of volatile oil three.
Preparation embodiment 10: the preparation four of Radix Peucedani volatile oil
Get Radix Peucedani medical material 100g in container, add 8 times amount water soakings after 1 hour, room temperature extracts 6 hours, collects volatile oil, obtains Radix Peucedani extractive of volatile oil four.
Preparation embodiment 11: the preparation five of Radix Peucedani volatile oil
Get Radix Peucedani medical material 100g, add 9 times amount water soakings after 1 hour, extract volatile oil 8 hours, in volatile oil catcher, collect volatile oil, obtain Radix Peucedani extractive of volatile oil five.
Preparation embodiment 12: the preparation six of Radix Peucedani volatile oil
Get Radix Peucedani medical material 100g, add 10 times amount water soakings after 1 hour, extract volatile oil 10 hours, obtain Radix Peucedani extractive of volatile oil six.
Preparation embodiment 13: the preparation seven of Radix Peucedani volatile oil
Get Radix Peucedani medical material 100g in container, add 9 times amount water soakings after 1 hour, room temperature extracts 8 hours, collects volatile oil, by the extractive of volatile oil beta cyclodextrin enclose obtained.
Experimental example: Radix Peucedani extract is on the impact of macrophage phagocytic function
1, test material:
Test adopts Kunming mouse, obtains from institute of Materia Medica,Chinese Academy of Medical Sciences
Cyclophosphamide is purchased from Qilu Pharmaceutical Co., Ltd.
2, test method: mice Carbon grain Kuo clear law
Carbon grain Kuo clear law is the common method measuring non-specific immunity, and it has reacted the phagocytic activity of macrophage.Certain density carbon granules enters blood through the injection of mouse orbit rear vein beard, takes the place such as liver, spleen to, and removed by the macrophage phagocytic at these positions through blood flow.Within the scope of finite concentration, the clearance rate of carbon granules and its dosage are in referring to functional relationship, and speed of namely engulfing is directly proportional to carbon granules concentration in blood, and is inversely proportional to the carbon granules amount of engulfing.If with the logarithm value of carbon granules concentration in blood for vertical coordinate, the time is abscissa, and both are then in linear relation, and its slope (K) value represents the speed of engulfing, namely not calibrated phagocytic index (namely cleaning up index).This is because Mouse Liver, spleen weight are not etc., therefore K value is different, so, generally represent with the phagocytic index α corrected (namely correct and clean up index), reacted the activate the phagocytic capacity of per unit tissue weight.
Be that the mice 40 of 18g-20g is divided into 4 groups at random by body weight, often organize 10, be respectively blank group, cyclophosphamide-a control group, Radix Peucedani water extract group and Radix Peucedani volatilization line of oils.For administration group (i.e. Radix Peucedani water extract group and Radix Peucedani volatilization line of oils), get Radix Peucedani water extract respectively or Radix Peucedani volatile oil gives medicinal liquid according to 1.40g crude drug/kg gavage, every day 2 times, continuous 7 days.Third and fourth sky of administration, administration group each mouse peritoneal injection cyclophosphamide 15mg/kg, once a day, continuous 2 days, administration the 7th day mouse weights, last administration is after 1 hour, tail vein injection black ink diluent 0.2ml, inject latter 1 minute, 5 minutes, get blood 20 μ l with capillary glass tube from retroorbital venous clump, be dissolved in 3ml 0.1%NaHCO
3solution shakes up, and is placed in spectrophotometer and measures optical density value (OD) at wavelength 650nm place 0.5cm cuvette, use 0.1%NaHCO
3solution is blank.Finally mice cervical dislocation is put to death, take liver, spleen weight respectively, clean up index K according to following formulae discovery or index α is cleaned up in correction, t inspection between organizing.Only give normal saline for blank group, for cyclophosphamide-a control group, only give cyclophosphamide.
Wherein, OD1, OD2 represent the blood sample optical density of 1 minute, 5 minutes after injection black ink respectively, t
2for second time blood sampling time, for this experiment namely 5 minutes, t
1for first time blood sampling time, for this experiment namely 1 minute.
Body weight shows the Mouse Weight of medicine after 7 days herein
3, result of the test
Blank group, cyclophosphamide-a control group, Radix Peucedani water extract group and other testing result of Radix Peucedani volatile oil compositions as shown in following table 1 ~ 4, each group of K value calculated and α value as shown in table 5.
Table 1: the testing result of blank group (blank group)
Table 2: the testing result of cyclophosphamide-a control group (cyclophosphamide group)
Table 3: the testing result of Radix Peucedani water extract group
Table 4: the testing result of Radix Peucedani volatilization line of oils
Table 5: each group of K value and α value calculated
* P < 0.05 is compared with cyclophosphamide-a control group
4, conclusion
As above shown in table 5, after injection cyclophosphamide, mice reticuloendothelial system phagocytic function obviously reduces, and the K value of Radix Peucedani water extract group and Radix Peucedani volatilization line of oils and α value all improve, this prompting Radix Peucedani water extract and Radix Peucedani volatile oil can improve the phagocytic activity of macrophage, thus have certain activation to reticuloendothelial system.
Hereafter by the kind of the constructive method and accessory drugs of listing the present composition, but the invention is not restricted to them.Representational preparation enforcement is described below.
the preparation of injection
Radix Peucedani water extract or volatile oil 100 milligrams (being less than 96.2%)
Sodium metabisulfite 3.0 milligrams
Methyl parahydroxybenzoate 0.8 milligram
Propyl p-hydroxybenzoate 0.1 milligram
Distilled water for injection is appropriate
Being prepared as follows of injection: lytic activity component, all components to about 7.5, is then filled in 2 milliliters of ampoules by control ph, and with the injection preparation method sterilizing of routine.
the preparation of powder
Radix Peucedani water extract or volatile oil 500 milligrams (70.4%)
Corn starch 100 milligrams
Lactose 100 milligrams
Pulvis Talci 10 milligrams
Powder preparation method is as follows: said components mixed, and loads in packing.
the preparation of tablet
Radix Peucedani water extract or volatile oil 200 milligrams
Corn starch 100 milligrams
Lactose 100 milligrams
Magnesium Stearate proper quantity
Tablet is by said components mixing and tabletting (entabletting) being obtained.
the preparation of capsule
Radix Peucedani water extract or volatile oil 100 milligrams
Lactose 50 milligrams
Corn starch 50 milligrams
Pulvis Talci 2 milligrams
Magnesium Stearate proper quantity
Capsule preparation is obtained in the gelatine capsule by said components mixing loading gelatin preparation method conveniently being prepared.
the preparation of liquid agent
Radix Peucedani water extract or volatile oil 1000 milligrams (1.64%)
Sugar 20 grams
Polysaccharide 20 grams
Lemon flavors 20 grams
Liquid agent preparation is by lytic activity composition, is then filled to by all components in 1000 milliliters of ampoules, and liquid preparation method sterilizing conveniently, obtained liquid agent.
the preparation of health food
Radix Peucedani water extract or volatile oil 1000 milligrams (being less than 68.67%)
Vitamin mixtures is appropriate
Axerophtholum aceticum 70 milligrams
Vitamin E 1.0 milligrams
Vitamin B
10.13 milligram
Vitamin B
20.15 milligram
Vitamin B6 0.5 milligram
Vitamin B12 0.2 milligram
Vitamin C 10 milligrams
Biotin 10 milligrams
Nicotinamide 1.7 milligrams
50 milligrams, folic acid
Calcium pantothenate 0.5 milligram
Mineral mixture is appropriate
1.75 milligrams, ferrous sulfate
Zinc oxide 0.82 milligram
Magnesium carbonate 25.3 milligrams
Potassium dihydrogen phosphate 15 milligrams
Dicalcium phosphate 55 milligrams
Potassium citrate 90 milligrams
Calcium carbonate 100 milligrams
24.8 milligrams, magnesium chloride
Above-mentioned vitamin and mineral mixture can change in many ways.Such change is not considered to depart from the spirit and scope of the invention.
the preparation of healthy beverage
Radix Peucedani water extract or volatile oil 1000 milligrams (1%)
Citric acid 1000 milligrams
Oligosaccharide 100 grams
Fructus Pruni concentrate 2 grams
Taurine 1 gram
Distilled water 900 milliliters
Healthy beverage is prepared as follows, lytic activity component, mixing, stirs 1 hour at 85 DEG C, filters, is then filled to by all components in 1000 milliliters of ampoules, and the preparation method sterilizing of healthy beverage conveniently.
Therefore, be illustrated above the present invention, clearly the present invention can change in many ways.Such change is not considered to depart from the spirit and scope of the present invention, and all these modifications will be apparent to those skilled in the art and be included in the scope of as above claim.
Industrial usability
As described in the invention, invention demonstrates by specific experiment the phagocytic activity that Radix Peucedani extract can improve macrophage, thus activate endothelium reticular system, and then effectively improve the non-specific immunity of body, therefore can be used as the therapeutic agent improving body's immunity or health food.
Claims (9)
1. Radix Peucedani extract is for the preparation of the purposes improved in the medicine of immunologic function.
2. purposes according to claim 1, wherein said Radix Peucedani extract is Radix Peucedani water extract or Radix Peucedani volatile oil.
3. purposes according to claim 1 and 2, wherein said immunologic function is non-specific immunity.
4. the purposes of Radix Peucedani extract in the medicine for the preparation of raising macrophages phagocytic capacity, described Radix Peucedani extract refers in particular to Radix Peucedani water extract or Radix Peucedani volatile oil.
5. a pharmaceutical composition, it contains Radix Peucedani extract as the active component improving immunologic function, and pharmaceutically acceptable carrier; Described Radix Peucedani extract refers in particular to Radix Peucedani water extract or Radix Peucedani volatile oil, and described immunologic function refers in particular to non-specific immunity.
6. pharmaceutical composition according to claim 5, it contains Radix Peucedani extract as the sole active agent improving immunologic function, and pharmaceutically acceptable carrier.
7. pharmaceutical composition according to claim 5 is for the preparation of the purposes improved in the medicine of immunologic function, and described immunologic function refers in particular to non-specific immunity.
8. the purposes of pharmaceutical composition according to claim 5 in the medicine for the preparation of raising macrophages phagocytic capacity.
9. a health food, it comprises Radix Peucedani extract as the upper acceptable additive of active component and threpsology improving immunologic function; Described Radix Peucedani extract refers in particular to Radix Peucedani water extract or Radix Peucedani volatile oil, and described immunologic function refers in particular to non-specific immunity.
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| CN201510393847.5A Pending CN104997821A (en) | 2015-07-07 | 2015-07-07 | Use of Radix Peucedani extract in immune function improvement |
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Cited By (1)
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| CN107714743A (en) * | 2017-11-30 | 2018-02-23 | 王博 | It is a kind of to be used to treat medicine of infantile respiratory tract infection repeatedly and preparation method thereof |
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| CN107714743A (en) * | 2017-11-30 | 2018-02-23 | 王博 | It is a kind of to be used to treat medicine of infantile respiratory tract infection repeatedly and preparation method thereof |
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