CN1125595C - Oral composition with cardiovascular health and senility delaying functions - Google Patents
Oral composition with cardiovascular health and senility delaying functions Download PDFInfo
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- CN1125595C CN1125595C CN 01108614 CN01108614A CN1125595C CN 1125595 C CN1125595 C CN 1125595C CN 01108614 CN01108614 CN 01108614 CN 01108614 A CN01108614 A CN 01108614A CN 1125595 C CN1125595 C CN 1125595C
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- edible oil
- oil
- fructus crataegi
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Abstract
The present invention relates to an oral composition with a cardiovascular health care function and a senescence delay function. The oral composition has a form suitable for oral administration by taking qingna oil, sallow thorn oil and the extracted mixture of hawthorn edible oil as effective components. If the gross weight of the effective components is 13 portions, the weight composition of each effective component is 7 to 12 portions of qingna oil, 0.5 to 3 portions of sallow thorn oil and 0.5 to 3 portions of extracted mixture of hawthorn edible oil. The extracted mixture of hawthorn edible oil is an edible oil mixture containing extracted components, which is prepared by the method that 1000 g of hawthorns is leached in 1500 ml of edible oil.
Description
Technical field
What the present invention relates to is a kind of Orally administered composition that has health-care effect and delaying senility function aspect cardiovascular system, and it both can be used as functional food, and the auxiliary medicaments that also can be used as in treating cardiovascular disease is used.
Background technology
Hyperlipidemia, coronary heart disease, and blood viscosity to increase etc. be present common and multiple disease.Owing to have the characteristics of chronicity in its prevention and the treatment, eat homologous viewpoint according to theory of Chinese medical science Chinese medicine, employing has some specific physiologically active effect and can be used as the natural materials or the raw material of food, make health care and/or the therapeutical effect of its performance aspect cardiovascular, and the characteristics that keep low toxicity or have no side effect, draw attention day by day, and in further investigation and exploitation.
Summary of the invention
At this situation, the present invention will provide a kind of compositions that derives from edible natural material and have the oral form of health-care effect aspect cardiovascular, make it both can be used as the functional food that has health care and preventive effect aspect cardiovascular, the auxiliary medicaments that also can be used as in treating cardiovascular disease is used.
The Orally administered composition that the present invention has cardiovascular health and a function of delaying senility is the form of the suitable for oral administration formed of effective ingredient by the edible oil extraction mixture of blue or green Na oil, Oleum Hippophae and short, bristly hair or beard, gross weight in effective ingredient is 13 parts, and the weight of each effective ingredient consists of:
Blue or green Na oil 7-12 part, Oleum Hippophae 0.5-3 part, edible oil extraction mixture 0.5-3 part of Fructus Crataegi, wherein the edible oil extraction thing of Fructus Crataegi is the edible oil mixture that extracts composition that contains after with 1500 milliliters of edible oil 1000 Keshan short, bristly hair or beards being leached.The form of said suitable for oral administration herein, can comprise as drop form, soft capsule form, micropore capsule form commonly used in the medicine, can also be to add the adding ingredient routinely that allows in the pharmacy and after making its solid typeization, further it is prepared into the form of solid dosage forms of the suitable for oral administration such as sheet, ball of appropriate format again.
Blue or green Na oil in the above-mentioned effective ingredient is contained lubricant component in the fruit of rosaceous plant Folium Prinsepiae Utilis (Prinscpia utilis Royle), can be squeezed by this fruit with the oil expression mode of routine to obtain.According to " Chinese medicine voluminous dictionary " record, the leaf of this plant is called " Folium Prinsepiae Utilis ", can be used as medicine, and has counteracting toxic substances, blood stasis dispelling effect, can be used for treating diseases such as skin sore, fracture, anemia; Its fruit is called " Fructus prinsepiae utilis ", and " Chinese medicine voluminous dictionary " puts down in writing that it is warm in nature, bitter in the mouth is sour, can have the removing nebula effect and is used to cure the many tears of corneal nebula.By the limpid and slightly flavous oily juice that squeezes in this fruit, be China's shuttle clansman ticbit and edible oil always that rub, also be used as health and beauty, among the peoplely think that it is a kind ofly to control the medicine of all kinds of diseases and ailments and be used for multiple treatment of diseases.Through the modern science check and analysis, be rich in unsaturated fatty acids such as Palmic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid in the oil that its fruit squeezes, and contain compositions such as vitamin E.Fructus Hippophae (Hippophae rhamnoidesL.) is a kind of go into liver, stomach, intestine and small intestine warp, have promoting blood circulation to remove blood stasis, the chest stuffiness relieving that reduces phlegm, spleen reinforcing is good for the stomach and the medicinal plants of multiple function such as promoting the production of body fluid to quench thirst, because of finding that it also contains multiple composition to the human body beneficial and becomes at present a kind of plant that important medical treatment and health care are worth that has, by the oiliness composition that squeezes in its seed core even be known as " oil plant gold "." Jilin Agriculture University's journal " [1999.21 (2)] report, a series of bioactive ingredients such as rich in vitamin E, unsaturated fatty acid, carotene, sterol in the Oleum Hippophae with different physiological roles.Fructus Crataegi is traditional medicinal raw material of natural plants, and " Chinese medicine information " [2000 (6), 29-30] are reported in to its Pharmacological action study, and its chemical constituent is mainly glycoside organic acid, flavonoid, terpenoid, the effect that has blood fat reducing, blood pressure lowering and invigorate blood circulation.Modern medicine study shows, unsaturated fatty acid can combine with cholesterol, form than being easier to turn round metabolism and excretory product, can also change cholesterol distribution in vivo simultaneously, make its more is deposited in the general tissue and cholesterol level in the minimizing blood vessel wall.Flavonoid substances has proved effects such as coronary dilating, blood fat reducing, blood viscosity lowering, antioxidation after deliberation.Vitamin E has removing interior free yl (SOD) and function in delaying senility.The above-mentioned Orally administered composition of the present invention is based on blue or green Na oil, the edible oil extraction mixture that is aided with Oleum Hippophae and Fructus Crataegi, show through zooperal result, can have the blood fat (TC), cholesterol (TG), low density lipoprotein, LDL (LDL-C) value that reduce hyperlipemia rat, the effect that improves high density lipoprotein (HDL-C) ratio simultaneously; Hyperlipidemia rabbit atherosclerosis there is significant inhibitory effect.Removing free radical test through fruit bat shows that it can have the effect that improves body endoperoxide dismutase (SOD) vigor and prolong life span of drosophila melanogaster.
The preparation of said blue or green Na oil and Oleum Hippophae can be adopted oil expression method commonly used at present, by squeezing in Princepia utilis and the Fructus Hippophae in the above-mentioned composition.For example, the preparation method that can be used as one of the embodiment of recommendation is, to clear up and shine Princepia utilis and/or Fructus Hippophae raw material after coarse powder (can be～10 orders) is removed the peel, is ground into to dry doubling, steaming before extracting oil is in the usual way fried and is handled after 1-3 hour, under the pressure of gauge pressure 〉=50 kilogram, squeeze and collect the oils and fats of squeezing out with spiral crusher, to its Residual oil≤7%, the solid shape precipitate of filtering promptly obtains operational limpid oils and fats.Experimental result also shows, steams the different moisture content and/or the temperature of frying when handling in the preparation process, and oil yield oily to blue or green Na and Oleum Hippophae can have certain influence.Therefore, generally blue or green Na oil and Oleum Hippophae are controlled at during preparation make its water content be 5%～30% and/or temperature be to steam to fry under 80 ℃～120 ℃ the condition to handle, be to obtain the expressed oil rate of comparatively being satisfied with.
The edible oil extraction thing of Fructus Crataegi can adopt various edible oil commonly used at present, and it can be the suitable oil as soybean oil, Oleum Arachidis hypogaeae semen, Semen Allii Tuberosi wet goods single form, also the various forms of mixed oils that can be made up of heterogeneity and/or ratio.After with selected edible oil Fructus Crataegi being extracted, separate containing the edible oil mixture that extracts composition and can directly use behind the disgorging again.Its extracting method generally can take with edible oil Fructus Crataegi to be carried out the mode of warm macerating.For example, the way of recommendation that can be used as one of embodiment is, is 50 ℃～100 ℃ with temperature, particularly 70 ℃～100 ℃ edible oil, to the Fructus Crataegi warm macerating after 1-4 hour, the filtering precipitate gets final product according to the above ratio, and the total flavones yield in its edible oil extraction mixture generally can be 3.6～5.6%.
In above-mentioned Orally administered composition, a kind of better and easily mode is to make the edible oil extraction thing of Oleum Hippophae in the said effective ingredient and Fructus Crataegi for equating or the basic consumption that equates.For example, a kind of composition mode that can be for reference when specifically implementing as above-mentioned composition of the present invention is: the weight of each effective ingredient consists of: 10 parts of blue or green Na oil, 1.5 parts of Oleum Hippophaes, 1.5 parts in the edible oil extraction mixture of Fructus Crataegi.The result that the related detection that Orally administered composition of the present invention by this composition form is carried out is analyzed shows, contain in its composition: vitamin E2 4.74mg/100g, zinc 0.29mg/100g, manganese 0.01mg/100g, calcium 1.52mg/100g, magnesium 0.21mg/100g, Palmic acid 15.5% (w/v), stearic acid 5.6%, oleic acid 38.5%, linoleic acid 38.2%, linolenic acid 1.4%, arachidic acid 0.6%.
As follows to the relevant test that biological activity that above-mentioned composition of the present invention had and helpfulness are carried out:
The blood fat reducing test
1. to hyperlipidemia rat fat influence experiment
With purebred senile rat is experimental animal, is divided into test group of the present invention, hyperlipidemia model group and blank group at random.The blank group is given normal diet, and all the other each groups all adopt high lipid food to feed three months, cause the hyperlipidemia animal model, and each group is given the above embodiment of the present invention composition form compositions in the mode of feeding respectively simultaneously then, carries out lipid-lowering test.Test group of the present invention is with the 100mg/kg administration, once a day, and successive administration three months.Be tested to after date, get hematometry TC, TG, LDL-C, HDL-C value respectively, and take statistics is handled.Result of the test shows that its hyperlipidemia to the hyperlipidemia rat has tangible reduction effect.Relevant experimental result is as shown in table 1 below.
The effect for reducing fat experimental result of table 1 pair hyperlipidemia rat
| Group | TC | TG | HDL-C | LDL-C |
| Matched group | 56.89±11.43 ** | 237.33±43.42 * | 47.77±8.38 * | 12.67±4.92 |
| The hyperlipidemia model group | 269.89±101.38 | 312.66±50.08 | 29.66±5.87 | 27.89±13.00 |
| Present composition group | 132.117±7.46 ** | 291.22±91.98 | 46.89±35.23 * | 11.89±7.32 ** |
In the table: compare with high fat group
*Be P＜0.05,
*Be P＜0.01.
2. to the atherosclerotic influence experiment of hyperlipidemia rabbit
With the big ear rabbit of Japan is experimental animal, is divided into blank group, test group of the present invention and hyperlipidemia model group at random.The blank group is given common private wealth, and all the other each treated animals were all fed four months with high lipid food, and each group adopts the mode of feeding to give the above embodiment of the present invention composition form compositions simultaneously then.Test group of the present invention is with 100mg/kg dosage, successive administration once a day.Be tested to after date, put to death animal, get aorta, observe the atherosclerosis plaque area and make the pathology sections observation.Result of the test shows that its hyperlipidemia to rabbit has tangible reduction effect, and can obviously suppress arteriosclerotic formation.Relevant experimental result is as shown in table 2 below.
The blood fat reducing of table 2 pair hyperlipidemia rabbit and suppress arteriosclerotic experimental result
| Group | TC | TG | HDL-C | LDL-C | Atherosclerosis plaque area piece |
| Matched group | 76.75±10.26 | 241.25±16.54 * | 56.60±4.39 * | 10.23±2.92 ** | 0 |
| High fat group | 325.63±76.75 | 378.77±19.00 | 34.41±3.11 | 32.09±9.63 | 85.62±1.34 |
| Present composition group | 145.40±90.23 | 265.91±9.76 * | 49.87±2.57 | 16.59±5.18 ** | 16.56±2.36 ** |
In the table: compare with high fat group
*Be P＜0.05,
*Be P＜0.01.
Prolong the survival life test
1. the test that life span of drosophila melanogaster is influenced
Make respectively and contain the culture medium of 1% the above embodiment of the present invention composition form compositions and use the culture medium that does not contain the present composition made from quadrat method.With the fruit bat is subjects, and the fruit bat ovum is put respectively in two culture medium, hatches the fruit bat adult with same method, observes the every index relevant with life span of drosophila melanogaster.Experimental result shows, the average life of above-mentioned composition energy significant prolongation fruit bat of the present invention.Experimental result is as shown in table 3 below.
The experimental result of table 3 pair life span of drosophila melanogaster influence
| Group | Sex | Average weight (ug) | The half death time (my god) | Average life (my god) | Maximum life span (my god) |
| Matched group | ♂ | 714.2 | 52.6 | 53.1 | 80.3 |
| ♀ | 923.7 | 61.4 | 60.9 | 99.2 | |
| Of the present invention group | ♂ | 728.2 | 65.2 | 62.4 *** | 81.4 |
| ♀ | 924.6 | 71.0 | 68.6 *** | 98.6 |
In the table: compare with matched group,
* *Be P＜0.001.
2. free radical scavenging test
Purebred rat is divided into test group of the present invention and blank group, and test group of the present invention is by feed the above embodiment of the present invention composition form compositions three months of 50mg/kg dosage, once a day.Be tested to after date, get whole blood and survey SOD vigor and blood plasma LPO content and NK activity, and take statistics is handled.Result of the test shows that compositions of the present invention has significant good effect aspect the removing of interior free yl.Result of the test is as shown in table 4 below
Table 4 is removed the free radical result of the test
| Group | SOD(U/ml) | LPO(μmol/L) | ND(％) |
| The blank group | 580±40 | 4.7±0.9 | 16±8 |
| Test group of the present invention | 646±61 *** | 4.0±0.9 *** | 21±9 ** |
In the table: compare with matched group,
*Be P＜0.05,
* *Be P＜0.01.
The observation of preliminary clinical effectiveness
To patient's 120 examples of suffering from cerebral arteriosclerosis, give the Orally administered composition of the above embodiment of the present invention composition form, by every day 2-3 time, the mode of each 2 grams (composition weight) is oral, and 4 weeks were a course of treatment, and observation is to the curative effect situation of disease.The result shows: wherein the main clinic symptoms that goes down such as the headache of 117 examples, dizziness all has alleviating in various degree, and leading indicators such as blood pressure, blood fat are by in various degree improvement.Its obvious effective rate 47.5%, effective percentage 50%, total effective rate are 97.5%.
Again to the patients of the high sticking hyperlipidemias of 97 examples, after the Orally administered composition of giving the above embodiment of the present invention composition form with the same manner was taken, its obvious effective rate was 59.5%, effective percentage is 27.8%, total effective rate 87.3%, and take all obviously reductions of back TC, TG index, HDL-C obviously rises.
Claims (5)
1. the Orally administered composition that has cardiovascular health and function of delaying senility, it is characterized in that edible oil extraction mixture by blue or green Na oil, Oleum Hippophae and Fructus Crataegi is the form of the suitable for oral administration formed of effective ingredient, gross weight in effective ingredient is 13 parts, and the weight of each effective ingredient consists of:
Blue or green Na oil 7-12 part, Oleum Hippophae 0.5-3 part, edible oil extraction mixture 0.5-3 part of Fructus Crataegi, wherein the edible oil extraction thing of Fructus Crataegi is the edible oil mixture that extracts composition that contains after with 1500 milliliters of edible oil 1000 Keshan short, bristly hair or beards being leached.
2. the Orally administered composition with cardiovascular health and function of delaying senility as claimed in claim 1, the edible oil extraction thing that it is characterized in that said Fructus Crataegi are that the soybean oil of Fructus Crataegi extracts mixture.
3. the Orally administered composition with cardiovascular health and function of delaying senility as claimed in claim 1, the edible oil extraction thing that it is characterized in that Oleum Hippophae and Fructus Crataegi in the said effective ingredient is for equating or the basic consumption that equates.
4. the Orally administered composition with cardiovascular health and function of delaying senility as claimed in claim 1 is characterized in that the weight of said each effective ingredient consists of:
10 parts of blue or green Na oil, 1.5 parts of Oleum Hippophaes, 1.5 parts in the edible oil extraction mixture of Fructus Crataegi.
5. as the described Orally administered composition with cardiovascular health and function of delaying senility of one of claim 1 to 4, the form that it is characterized in that said suitable for oral administration is the soft capsule form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01108614 CN1125595C (en) | 2001-07-10 | 2001-07-10 | Oral composition with cardiovascular health and senility delaying functions |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01108614 CN1125595C (en) | 2001-07-10 | 2001-07-10 | Oral composition with cardiovascular health and senility delaying functions |
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| CN1331920A CN1331920A (en) | 2002-01-23 |
| CN1125595C true CN1125595C (en) | 2003-10-29 |
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| CN 01108614 Expired - Lifetime CN1125595C (en) | 2001-07-10 | 2001-07-10 | Oral composition with cardiovascular health and senility delaying functions |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101507766B (en) * | 2009-03-30 | 2011-12-14 | 四川农业大学 | Preparation method of traditional Chinese medicine capsules with blood-fat reduction and health-care function and use thereof |
| CN116688009A (en) * | 2023-06-08 | 2023-09-05 | 成都瑞翔生物技术有限公司 | A Chinese medicinal composition with atherosclerosis and anoxia resisting effects |
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