KR20170110498A - Composition for contact lens - Google Patents

Abstract

The present invention relates to a contact lens composition, which comprises a hydrophilic monomer, a crosslinking agent, and a useful substance obtained from a soybean, as a contact lens composition for forming a hydrophilic surface layer on a substrate of a contact lens. Accordingly, the present invention relates to a method for producing a contact lens, which comprises mixing a useful substance obtained from a soybean, a hydrophilic monomer and a cross-linking agent on a substrate of a contact lens to form a hydrophilic surface layer so as to satisfy the basic physical properties as a contact lens, And it is possible to prevent various ocular side effects.

Description

[0001] COMPOSITION FOR CONTACT LENS [0002]

The present invention relates to a contact lens composition, and more particularly, to a contact lens composition for forming a hydrophilic surface layer on a base material of a contact lens.

Generally, contact lenses can be roughly divided into hard contact lenses and soft contact lenses depending on the material, and they are classified into vision correction, therapeutic, and cosmetic contact lenses according to functions.

Hydrogel is a representative material of soft contact lenses used by modern people for the purpose of vision correction and treatment. Most hydrogel contact lenses are based on silicon or acrylate.

The cornea of the human eye is free of blood vessels and is structured to receive oxygen directly from the external environment. However, when the contact lens is worn, the lens itself acts as a kind of barrier to reduce the oxygen permeability.

General hydrogel contact lenses have problems such as hypoxia (corneal edema) due to low oxygen permeability (corneal edema) and wettability of the lens surface due to leakage components adhering to the lens surface, although many people prefer it because of comfortable fit. Therefore, hydrogel contact lenses are required not only to have excellent wearing comfort, but also to have high oxygen permeability and wettability.

In order for general people to successfully wear contact lenses, it is necessary to limit the effect of hypoxia on the cornea. For this purpose, a high function lens is used. Due to the lens fold phenomenon (hula phenomenon) And it causes a variety of keratitis.

As an alternative to this, when silicone hydrogel contact lenses are worn, sufficient oxygen is supplied to the eyes and there is no side effect of corneal edema due to hypoxia. However, silicon-based hydrogel contact lenses are less comfortable to wear.

That is, due to the characteristics of the silicone-based hydrogel material, the oxygen permeability increases sufficiently as the silicon content increases, but the hydrophilicity of the lens surface decreases. As a result, the wearer is inconvenienced and problems such as eye irritation, corneal staining, lens sticking to the cornea, and the like arise.

In order to overcome this disadvantage, the surface of the lens was treated with a plasma to increase its hydrophilicity. However, this has still caused inconvenience to the user due to low wettability of the surface, and a complicated process such as plasma surface treatment is added to the top of the manufacturing process, which causes a rise in the production cost.

Another method is to use a polymer without a post-plasma treatment process to increase the wettability and moisture content of the contact lens. However, there is a problem in that the internal wetting agent gradually slips out of the lens, thereby causing the wearer to feel discomfort.

Korean Patent No. 10-0748379 (August 10, 2007) Korean Patent No. 10-1367538 (February 26, 2014) Korean Patent No. 10-1599913 (March 04, 2016)

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art, and an object of the present invention is to provide a contact lens composition capable of preventing various ocular side effects by increasing the wettability, protein decomposition function and oxygen permeability of the lens surface while satisfying basic physical properties as a contact lens. The purpose is to provide.

It is still another object of the present invention to provide a contact lens composition which can improve the feeling of wearing of a contact lens and improve transparency.

It is still another object of the present invention to provide a contact lens composition which can facilitate the step of forming a hydrophilic surface layer.

Another object of the present invention is to provide a contact lens composition capable of improving the modifying performance and deposition performance between the contact lens base material and the hydrophilic surface layer and minimizing the side effect of the eyeball.

According to an aspect of the present invention, there is provided a contact lens composition for forming a hydrophilic surface layer on a base material of a contact lens, the contact lens composition comprising: a hydrophilic monomer; A crosslinking agent; And a useful substance obtained from soybeans.

The base material of the contact lens of the present invention is characterized by being composed of an acrylate-based hydrogel or a silicone-based hydrogel. The thickness of the penetrating layer formed between the base material of the contact lens of the present invention and the hydrophilic surface layer is 20 to 40 nm.

The hydrophilic monomer of the present invention is characterized by being a hydrophilic acrylic monomer or a hydrophilic silicone acrylic monomer.

The cross-linking agent of the present invention is preferably selected from the group consisting of ethylene glycol dimethacrylate (EGDMA), diethylene glycol methacrylate (DEGMA), glycerol dimethacrylate (GDMA), divinylbenzene (DVB) and trimethylolpropane trimethacrylate (TMPTMA). ≪ / RTI >

The useful substance of the present invention is characterized by being a polygamma glutamic acid or a natokinase.

On the other hand, the hydrophilic surface layer forming method of the contact lens of the present invention

(A) producing natto by soybean fermentation;

(B) adding the natto to a solution of 85 to 95% by weight of water and 5 to 15% by weight of ethanol to extract the mucus solution and isolate it;

(C) 100 parts by weight of water, 6.5 to 12 parts by weight of the above-mentioned viscous solution, 0.55 to 1.05 part by weight of sodium chloride, 0.1 to 0.3 part by weight of disodium hydrogenphosphate, and 0.05 to 0.15 part by weight of potassium chloride, Producing; And

(D) immersing the contact lens in the coating solution, and heating the contact lens at 110 to 130 DEG C for 15 to 30 minutes.

In addition, the viscosity of the mucus solution in the step (C) may be 30 to 50 cp.

Further, the thickness of the hydrophilic surface layer may be 40 nm to 2 탆.

On the other hand, the contact lens of the present invention is characterized by having a hydrophilic surface layer formed by the above-mentioned forming method.

As described above, the present invention provides a hydrophilic surface layer by mixing a useful substance obtained from soybean with a hydrophilic monomer and a cross-linking agent on a substrate of a contact lens to form a hydrophilic surface layer, thereby satisfying basic physical properties as a contact lens, Function and oxygen permeability, thereby preventing various ocular side effects.

Further, the contact lens is made of an acrylate-based hydrogel or a silicone-based hydrogel as a base material of the contact lens, thereby providing an effect of improving the fit of the contact lens and improving the transparency.

Further, by limiting the thickness of the penetration layer formed between the base material of the contact lens and the hydrophilic surface layer to a predetermined dimension, it is possible to facilitate the process of forming the hydrophilic surface layer.

Further, by using a hydrophilic acrylic monomer or a hydrophilic silicone acrylic monomer as a hydrophilic monomer and using a plurality of species as a crosslinking agent and using polygamma glutamic acid or a natokinase as a useful substance, it is possible to improve the modifying performance and the deposition performance between the contact lens substrate and the hydrophilic surface layer And at the same time, minimize side effects of the eyeball.

Hereinafter, a preferred embodiment of the present invention will be described in more detail.

The contact lens composition of the present embodiment is a contact lens composition comprising a hydrophilic monomer, a cross-linking agent, and a useful substance obtained from soybeans to form a hydrophilic surface layer on a substrate of a contact lens.

As a base material of such a contact lens, a contact lens can be formed using hydrogel contact lens base materials of various materials, but in this embodiment, it is preferable that it is made of an acrylate-based hydrogel or a silicone-based hydrogel.

As such a hydrogel contact lens base material, for example, an acrylate hydrogel or a silicone hydrogel commonly used as a hydrogel contact lens may be used.

Therefore, it is needless to say that such a hydrogel contact lens substrate can be used as a transparent hydrogel contact lens or can be used variously as a color hydrogel contact lens in which a pigment is printed.

The base material of the hydrogel contact lens base may be a hydrophilic acrylic polymer, a hydrophilic silicone polymer or a hydrophilic silicone-acrylic polymer, and these polymers are not particularly limited as long as they can form a hydrogel.

In addition, the hydrogel contact lens base material may include 80% by weight or more of the polymer, based on the total weight, for example, 80% by weight to 100% by weight, 85% by weight to 99.9% % To 98% by weight.

In addition, the hydrogel contact lens base can be prepared by, for example, a cast molding method and a spin casting method, but the production method thereof is not particularly limited.

Such a hydrogel contact lens base material is produced by a cast molding method in one example, and a mixed solution containing a hydrophilic monomer, a crosslinking agent and an initiator is injected into a mold mold, And can be produced by molding into a shape. At this time, the hydrophilic monomer is not particularly limited, and a hydrophilic acrylic monomer or a hydrophilic silicone acrylic monomer may be used.

Such hydrophilic acrylic monomers include, for example, C1-C15 hydroxyalkyl methacrylates substituted with 1 to 3 hydroxy groups, C1-C15 hydroxyalkyl acrylates substituted with 1 to 3 hydroxy groups, acrylamide ), Vinyl pyrrolidone, glycerol methacrylate, acrylic acid, and methacrylic acid may be used alone or in combination of two or more.

Such a hydrophilic acrylic polymer is more specifically exemplified by 2-hydroxyethyl methacrylate (HEMA), N, N-dimethylacrylamide (DMA), N-vinylpyridine One or two or more selected from N-vinyl pyrrolidone (NVP), glycerol monomethacrylate (GMMA), and methacrylic acid (MAA) may be used.

In addition, the hydrophilic silicone acrylic monomer may include a polydimethylsiloxane-based compound and the like. Specific examples of the hydrophilic silicone acrylic monomer include tris (3-methacryloxypropyl) silane, 2- (trimethylsilyloxy) ethyl methacrylate, 3-tris (trimethylsilyloxy) silylpropyl methacrylate, 3- ≪ RTI ID = 0.0 >

Silane (MPTS), 3-methacryloxy-2- (hydroxypropyloxy) propylbis (trimethylsiloxy) methylsilane and 4-methacryloxybutyl terminated polydimethylsiloxane. More than species can be used.

The cross-linking agent is selected from among ethylene glycol dimethacrylate (EGDMA), diethylene glycol methacrylate (DEGMA), glycerol dimethacrylate (GDMA), divinylbenzene (DVB) and trimethylolpropane trimethacrylate (TMPTMA) One or more selected ones may be used.

The initiator is also for polymerization, for example, azodiisobutylonitrile (AIBN) and benzoin methyl ether (BME), 2,5-dimethyl-2,5-di- (2-ethylhexanoylper Oxy) hexane, dimethoxyphenylacetophenone (DMPA), and the like.

At the time of forming the hydrophilic surface layer on the substrate of the contact lens, first, the hydrogel contact lens substrate is prepared, and then the surface of the hydrogel contact lens substrate is modified to form a hydrophilic surface layer. At this time, such a hydrophilic surface layer includes polygamma glutamic acid or a natokinase obtained from soybean, a hydrophilic monomer and a cross-linking agent.

Specifically, a surface modifying solution containing polygamma glutamic acid, a hydrophilic monomer and a crosslinking agent is prepared, and then the hydrogel contact lens substrate is immersed in the surface modifying solution. More specifically, the hydrogel contact lens substrate is immersed in a surface modification solution in which poly (gamma glutamic acid) and hydrophilic monomers are dissolved to form a hydrophilic surface layer on the surface of the hydrogel contact lens substrate.

At this time, the hydrophilic monomer may form an Inter-Penetrated Network (IPN) structure with poly-gamma-glutamic acid in the course of polymerization with a hydrophilic polymer through a crosslinking agent.

That is, the hydrophilic surface layer is formed from a mixture containing polygamma glutamic acid, a hydrophilic monomer and a crosslinking agent, and a hydrophilic polymer formed by crosslinking a hydrophilic monomer is introduced into the substrate surface in an interpenetrating network (IPN) structure with polygamma glutamic acid, Thereby forming a physically intermixed penetration layer between the lens substrate and the hydrophilic surface layer.

The thickness of the penetrating layer formed between the substrate of the contact lens and the hydrophilic surface layer is preferably 20 to 40 nm.

Particularly, the hydrophilic surface layer preferably has a thickness of 40 nm to 2 탆. At this time, if the thickness of the hydrophilic surface layer is less than 40 nm, the hydrophilicity is low and the wettability improvement effect of the lens surface may be insignificant. If the thickness of the hydrophilic surface layer is more than 2 mu m, the shape of the surface-modified contact lens may be deformed, and in some cases, the oxygen permeability and optical characteristics may be lowered, which may adversely affect the basic functions of the contact lens to be.

Thus, the useful substance obtained from soybean is preferably composed of polygamma glutamic acid extracted with chungkukjang using soybean or natokinase extracted from natto using soybean.

Poly-g-Glutamic Acid (PGA) is a g-polypeptide in which the g-carboxyl group of glutamic acid and the g-amino group of glutamic acid are amide bonded. The poly (glutamic acid) Soluble, anionic, biodegradable and edible amino acid polymer material produced by a g-PGA synthetase complex (pgsBCA system), which is suitable for the component fusion of the silicone hydrogel of this embodiment.

Polygamma glutamic acid is an anionic polymer in which the a-carboxyl group is exposed. The structure of the polygamma glutamic acid in the aqueous solution of polygamma glutamic acid differs depending on the degree of ionization. The structural characteristics of polygamma glutamic acid are different depending on the pH of the aqueous solution , And studies on these structural properties may increase the applicability of poly (gamma glutamic acid).

Nattokinase is a fibrinolytic enzyme produced by the ingestion and growth of soybean nutrients during the fermentation of soybean, which contains vitamin B group and a large amount of antioxidant enzyme.

These natokinases are abundant in natto and chongkukjang, and are good for cardiovascular diseases because they have strong thrombolytic ability and pro-urokinase (pro-urokinase) activation ability.

Natokinase is not contained in soybeans, but when fermenting soybeans, Bacillus natto is a thrombolytic enzyme that produces and nourishes the nutrients of soybeans. Vitamin K is eliminated and vitamin B group and a large amount of antioxidant enzymes are contained .

In particular, the enzyme, natokinase, can be destroyed by heat, so it is better not to heat it for too long. However, when the enzyme is heated for 30 minutes at 65 ° C, the enzyme activity decreases to about 2% strong. In addition to natto, natto bacteria are also contained in large amounts in Chongkukjang.

On the other hand, the hydrophilic surface layer forming method of the contact lens of the present invention

(A) producing natto by soybean fermentation;

(B) adding the natto to a solution of 85 to 95% by weight of water and 5 to 15% by weight of ethanol to extract the mucus solution and isolate it;

(C) 100 parts by weight of water, 6.5 to 12 parts by weight of the above-mentioned viscous solution, 0.55 to 1.05 part by weight of sodium chloride, 0.1 to 0.3 part by weight of disodium hydrogenphosphate, and 0.05 to 0.15 part by weight of potassium chloride, Producing; And

(D) immersing the contact lens in the coating solution, and heating the contact lens at 110 to 130 DEG C for 15 to 30 minutes.

In addition, the viscosity of the mucus solution in the step (C) may be 30 to 50 cp.

Further, the thickness of the hydrophilic surface layer may be 40 nm to 2 탆.

On the other hand, the contact lens of the present invention is characterized by having a hydrophilic surface layer formed by the above-mentioned forming method.

As described above, according to the present invention, by forming a hydrophilic surface layer by mixing a usable substance obtained from soybeans with a hydrophilic monomer and a cross-linking agent on a substrate of a contact lens, the wettability and protein decomposition Function and oxygen permeability, thereby preventing various ocular side effects.

Further, the contact lens is made of an acrylate-based hydrogel or a silicone-based hydrogel as a base material of the contact lens, thereby providing an effect of improving the fit of the contact lens and improving the transparency.

Further, by limiting the thickness of the penetration layer formed between the base material of the contact lens and the hydrophilic surface layer to a predetermined dimension, it is possible to facilitate the process of forming the hydrophilic surface layer.

Further, by using a hydrophilic acrylic monomer or a hydrophilic silicone acrylic monomer as a hydrophilic monomer and using a plurality of species as a crosslinking agent and using polygamma glutamic acid or a natokinase as a useful substance, it is possible to improve the modifying performance and the deposition performance between the contact lens substrate and the hydrophilic surface layer And at the same time, minimize side effects of the eyeball.

Example

Example: Preparation of Contact Lens Having Hydrophilic Surface Layer

After producing natto by fermentation with soybeans, the natto was added to a solution of 1 liter of distilled water and 10 ml of ethanol to extract the mucous solution, which was then separated. Separately, a coating solution prepared by mixing 90 ml of a mucilage solution having a viscosity of 40 cp, 8 g of sodium chloride, 2 g of disodium hydrogenphosphate and 1 g of potassium chloride was added to 1 L of water, and the contact lens was immersed therein Followed by heating at 121 < 0 > C for 21 minutes. As a result, a contact lens having a hydrophilic surface layer of 1 mu m was obtained.

The present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. Therefore, the above embodiments are merely illustrative in all respects and should not be construed as limiting.

Claims (10)

A contact lens composition for forming a hydrophilic surface layer on a base material of a contact lens,
Hydrophilic monomers;
A crosslinking agent; And
And a useful substance obtained from soybean. The method according to claim 1,
Wherein the base material of the contact lens is made of an acrylate-based hydrogel or a silicone-based hydrogel. The method according to claim 1,
Wherein the thickness of the penetrating layer formed between the base material of the contact lens and the hydrophilic surface layer is 20 to 40 nm. The method according to claim 1,
Wherein the hydrophilic monomer is a hydrophilic acrylic monomer or a hydrophilic silicone acrylic monomer. The method according to claim 1,
The crosslinking agent may be at least one selected from the group consisting of ethylene glycol dimethacrylate (EGDMA), diethylene glycol methacrylate (DEGMA), glycerol dimethacrylate (GDMA), divinylbenzene (DVB) and trimethylolpropane trimethacrylate (TMPTMA) , Wherein the contact lens composition is at least one selected from the group consisting of a silicone oil, The method according to claim 1,
Wherein said useful substance is polygamma glutamic acid or a natokinase. (A) producing natto by soybean fermentation;
(B) adding the natto to a solution of 85 to 95% by weight of water and 5 to 15% by weight of ethanol to extract the mucus solution and isolate it;
(C) 100 parts by weight of water, 6.5 to 12 parts by weight of the above-mentioned viscous solution, 0.55 to 1.05 part by weight of sodium chloride, 0.1 to 0.3 part by weight of disodium hydrogenphosphate, and 0.05 to 0.15 part by weight of potassium chloride, Producing; And
(D) immersing the contact lens in the coating solution and heating the contact lens at 110 to 130 DEG C for 15 to 30 minutes. The method of claim 7,
Wherein the viscous solution of step (C) has a viscosity of 30 to 50 cp. The method of claim 7,
Wherein the hydrophilic surface layer has a thickness of 40 nm to 2 占 퐉. A contact lens comprising a hydrophilic surface layer formed by the method for forming a claim of any one of claims 7 to 9.