KR20140019685A - Healthy and functional food for the improvement of blood flow - Google Patents

Healthy and functional food for the improvement of blood flow Download PDF

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KR20140019685A
KR20140019685A KR1020120086276A KR20120086276A KR20140019685A KR 20140019685 A KR20140019685 A KR 20140019685A KR 1020120086276 A KR1020120086276 A KR 1020120086276A KR 20120086276 A KR20120086276 A KR 20120086276A KR 20140019685 A KR20140019685 A KR 20140019685A
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vitamin
extract powder
blood flow
blood
lactose
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KR101424335B1 (en
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장대길
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스타링포스 주식회사
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16Inorganic salts, minerals or trace elements
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • A23V2200/326Foods, ingredients or supplements having a functional effect on health having effect on cardiovascular health

Abstract

The present invention relates to health food for improvement of blood flow, capable of helping users to maintain health by administration and improving blood flow. The health food contains 0.134% of vitamin A, 0.27% of vitamin B1 hydrochloride, 15% of vitamin C, 1.12% of vitamin E mixture, 0.0008% of vitamin B12, 0.32% of nicotinic acid amide (niacin), 0.102% of copper sulfate, 1.7% of magnesium oxide, 5.55% of L-glutamine, 5.55% of L-lysine hydrochloride, 1.4% of N-acetylglucosamine, 2.45% of inositol, and 6.95% of taurine. [Reference numerals] (AA) System; (BB) Boiling step; (CC) Cooling step; (DD) Peel stripping step; (EE,FF) Non-prescription; (GG,HH) Time

Description

혈류량 개선을 위한 건강기능식품{Healthy and functional food for the improvement of blood flow}{Healthy and functional food for the improvement of blood flow}

본 발명은 사람들이 복용함으로써 혈류량을 개선함으로써 건강유지에 도움을 줄 수 있는 혈류량 개선을 위한 건강기능식품에 관한 것이다.BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a health functional food for improving blood flow which can help maintain health by improving blood flow by taking by people.

최근, 식생활의 서구화, 운동 부족, 과도한 스트레스 등의 생활 환경의 변화에 따라 동맥경화증, 뇌경색 등의 혈액이나 순환기계에 관련한 질환 및 고지혈증, 당뇨병 등의 혈액 순환에 악영향을 미치는 질환이 증가되고 있다. 이들 질환은 미소 혈관이나 모세혈관의 혈류의 저하를 일으키므로 생체에 다양한 악영향을 줄 위험성이 지적되고 있다. 또한, 혈류가 피부의 가려움, 피로, 고혈압 등과도 관계가 있는 것도 보고되고 있다.Recently, diseases affecting blood circulation such as atherosclerosis, cerebral infarction and the like, and blood circulation such as hyperlipemia and diabetes are increasing due to changes in the living environment such as westernization of diet, lack of exercise, and excessive stress. These diseases cause a decrease in blood flow of microvasculature and capillary blood vessels, and thus, there is a danger that various diseases may be adversely affected. It has also been reported that blood flow is also associated with itching, fatigue, hypertension, and the like of the skin.

일반적으로 혈액순환(the circulation of blood)즉, 혈류는 혈액이 심장을 중심으로 혈관을 따라 우리의 신체를 순환하는 것으로 산소를 신체 각 조직에 공급하고 탄산가스를 방출하고, 영양소를 보급하고 대사산물을 방출하며, 여러 내분비선에서 호르몬을 운반하여 특정기관의 기능을 조절하며 그밖에 병원균 조절작용과 체온조절, 삼투압조절, 수분조절 등의 기능을 수행하는 과정이다. 혈관은 동백, 모세혈관, 정맥으로 구성되어 있다. 동맥은 외탄력선판과 결합조직으로 되어 있는 외막, 평활근이 많고 그 안에 다수의 탄력섬유를 함유하고 있는 중막, 제일 안쪽의 내피세포와 그것을 둘러싸고 있는 결합조직과 탄력섬유가 모여서 내강성판으로 되어 있는 내막으로 이루어져 있다. 모세혈관은 소동맥과 소정맥이 연결된 것으로 그물모양으로 가늘게 가지가 나 있으며 직경 0.008~0.02mm의 가는관으로서 적혈구가 통과될 정도이고 육안으로는 보이지 않으며, 이 모세혈관을 통해서 혈액 중의 산소와 영양분은 조직내로 보내지고 조직에서 만들어진 이산화탄소(CO2)나 노폐물은 혈관으로 들어온다. 정맥의 외막은 비교적 두껍고 내막과 중막은 얇으며 압력이 없고 다른 혈관에 비해 혈류가 약하여 심장보다 낮은 부분의 정맥에서 역류할 위험성이 있기 때문에 역류 방지용 판막(valve)이 붙어 있다.The circulation of blood, that is, the blood circulation around the heart around the blood circulation of our body by supplying oxygen to the body tissues, carbon dioxide emissions, nutrients, and metabolic products And hormone transport in various endocrine glands to regulate the function of specific organs, as well as pathogen control, body temperature control, osmotic pressure control, moisture control is a process to perform functions. The blood vessels consist of camellias, capillaries, and veins. The artery is composed of an outer membrane composed of an external elastic plate and connective tissue, a middle membrane containing many smooth muscles and a large number of elastic fibers therein, an inner membrane of the innermost endothelial cells, a connective tissue surrounding the inner membrane, Lt; / RTI > The capillary blood vessels are connected with the small arteries and the parietal arteries. They have a narrow net shape and are thin tubes with a diameter of 0.008-0.02mm. They pass through red blood cells and are not visible to the naked eye. Through this capillaries, oxygen and nutrients in blood And the carbon dioxide (CO2) and wastes produced by the tissue enter the blood vessel. The outer membrane of the vein is relatively thick, the inner membrane and the middle membrane are thin, and there is a valve to prevent backflow because there is no pressure and there is a risk of backflow in the vein lower than the heart due to weaker blood flow than other blood vessels.

또한, 혈액순환 장애란 우리 온몸의 구석구석에 뻗어 있는 혈관이 탄력을 잃고 내벽에 콜레스테롤 등이 침착되어 혈관 내강이 좁아져 혈액 순환이 원활이 이루어지지 못하는 것을 말한다. 혈액순환 장애는 손발 차고 저림, 뒷목 당김, 어깨 결림, 기억력 감퇴, 무기력, 집중력 약화, 현기증 및 만성 피로 증상을 유발하여 정상적인 생활을 영위하는데 어려움이 많게 된다.In addition, blood circulation disorder means that the blood vessels extending to all corners of our body lose their elasticity and cholesterol is deposited on the inner wall, and the blood circulation is not smooth due to narrowing of the lumen. Blood circulation disorder causes difficulty in maintaining normal life by causing limbs, limbs, stiff shoulders, memory loss, weakness, weakness of concentration, dizziness and chronic fatigue symptoms.

혈액순환에 장애가 생겨 발생하는 심혈관계 질환으로 고혈압, 동맥경화증, 심장병, 뇌졸중 등은 오늘날 성인병의 주종을 이루고 있으며 사망률이 높은 질병으로 70세까지는 암에 의한 사망률이 가장 높으나 70세 이후에는 심혈관계 질환이 제 1의 사망원인이다. 이러한 심혈관계 질환은 서로 밀접한 관련이 있는데, 이미 상술한 바와 같이 급속한 경제의 발전, 식생활의 발전, 사회 환경의 변화와 서구화로 질병양상이 서구화되어 가면서 증가하고 있으며, 총 칼로리 섭취 증가와 지방섭취 증가로 콜레스테롤을 비롯하여 혈중 지질치의 현저한 상승을 초래하여 관상동맥질환, 뇌졸중, 말초혈관질환과 같은 동맥경화성 심혈관 질환 발생도 현저히 증가하고 있다. 고지혈증, 동맥경화증, 심근 경색증 및 뇌혈전증 등 심혈관계 질환의 발생원인은 높은 지방함량과 식이섬유 함량이 적은 가공식품의 섭취, 유전적인 요인, 흡연, 음주, 고혈압, 당뇨, 비만, 운동부족, 과도한 스트레스 등이 관여한다고 널리 알려져 있으며, 이러한 심혈관계 질환을 일으키는 기본적인 병변은 동맥경화증으로 그 원인에 대한 역학적 및 실험적 연구로 다양한 위험인자를 밝혀내고 있다. 이러한 병변의 발생과정을 살펴보면, 물리적 또는 화학적인 상처는 혈관의 단층세포표면에 손상을 야기하고, 혈관벽에 혈전 생성을 유도할 수 있는 혈전 부착 수용체가 발현되고, 여기에 단구(monocyte), T-임파구(T-lympocyte) 및 혈소판 등이 부착하여, 혈관 내막세포 사이를 통하여 혈관벽 속으로 침윤하게 되는데, 이때, 혈액 속의 지질단백질도 함께 유입된다. 혈관벽 내부로 유입된 단구들은 지질단백질을 탐식하여 대식세포(macrophage)로 변형되고, 대식세포들은 콜레스테롤을 축적하여 포말세포(form cells)를 형성한다. 포말세포들은 염증반응과 세포성장을 반복하면서 혈관벽을 파괴하거나 비후하여, 혈액중의 혈소판이 점착됨으로 혈전을 형성하게 한다. 이러한 진행과정은 결국, 동맥경화에 의한 혈관의 협착과 혈전에 의한 혈관의 완전 폐쇠로 심장으로의 혈액공급이 순간적으로 차단되어, 심근경색에 의한 사망을 유도한다.It is a major cardiovascular disease caused by obstruction of blood circulation. Hypertension, arteriosclerosis, heart disease, stroke are the major diseases of today's adult diseases and mortality rate is the highest. Cancer death rate is the highest until 70 years old. This is the first cause of death. These cardiovascular diseases are closely related to each other. As already mentioned above, as the development of the economy, the development of the eating habits, the change of the social environment and westernization, the disease pattern is increasing as westernized, and the increase in total calorie intake and fat intake As a result, the incidence of atherosclerotic cardiovascular diseases such as coronary artery disease, stroke, and peripheral vascular disease is remarkably increased due to a significant increase in blood lipid levels including cholesterol. The causes of cardiovascular diseases such as hyperlipidemia, atherosclerosis, myocardial infarction and cerebral thrombosis are caused by intake of high fat content and processed foods with low dietary fiber content, genetic factors, smoking, drinking, hypertension, diabetes, obesity, lack of exercise, . These basic cardiovascular disease-causing lesions are arteriosclerosis, which is characterized by epidemiological and experimental studies on the etiology and causes of various risk factors. These lesions are characterized by physical or chemical scars that cause damage to the surface of the monolayer of blood vessels, and thrombus adhesion receptors capable of inducing thrombus formation in the blood vessel wall are expressed. Monocytes, T- T-lympocytes and platelets adhere to the blood vessels through the vascular endothelial cells. At this time, lipid proteins in the blood also enter the blood vessels. The monoliths that enter the blood vessel wall digest lipid proteins and transform them into macrophages, and macrophages accumulate cholesterol to form cells. Foam cells break inflammatory reaction and cell growth while destroying or enlarging the blood vessel wall, causing blood platelets to adhere to form blood clots. This progression eventually leads to myocardial infarction death by momentarily blocking blood supply to the heart due to stenosis of the blood vessel due to arteriosclerosis and complete closure of the blood vessel due to thrombus.

특히 혈류는 고혈당에 의해 혈액의 유동성, 적혈구나 백혈구의 유연성 또는 혈소판의 응집능력 등의 영향을 받게 된다. 특히, 적혈구 및 백혈구 등의 혈구는 혈액 체적의 약 40%를 차지한다고 하며, 미세한 혈관에서는 특히 혈액의 유동성에 영향을 준다. 이러한 혈류가 저하되는 상태가 오래 계속되면, 예를 들면, 혈관의 유연성이 상실되며 적혈구의 유연성이 나빠지는 미소 혈관에서 적혈구 또는 백혈구가 막히기 쉬워지는 혈전을 형성하기 쉬워지는 등의 현상을 야기하며, 순환기계 질환의 발병의 한가지 원인으로 된다. 중독인 경우에는 혈액의 흐름이 중지되며 이의 주변부에서 조직의 괴사가 일어난다. 그러므로, 「생체내의 혈액의 유동 용이성」은 건강을 유지하는 데에 중요시되게 되어 있다.Particularly, blood flow is influenced by blood flow, the flexibility of red blood cells, leukocytes, or the ability of platelets to aggregate due to hyperglycemia. In particular, blood cells such as red blood cells and leukocytes account for about 40% of the blood volume, and it affects the fluidity of blood particularly in fine blood vessels. Such a state in which the blood flow is lowered for a long time causes, for example, a phenomenon that the flexibility of the blood vessel is lost and the blood clot that makes the erythrocyte or leukocyte clogged easily in the micro blood vessel where the flexibility of the red blood cell is bad, It is one of the causes of circulatory disease. In the case of poisoning, blood flow stops and tissue necrosis occurs at the periphery of the blood. Therefore, " ease of flow of blood in the living body " is important for maintaining health.

따라서 혈류를 개선시킬 가능성이 있는 식품 및 식품 성분이 다수 개발 보고되어 있다. 예를 들면, 가까운 식품재로서는 흑식초, 매실 장아찌 등을 들 수 있다. 또한, 일본 공개특허공보 제(평)7-138168호에서는 어류 담즙의 극성 용매 추출물이 혈액의 유동성을 개선시키는 것이 보고되어 있다. 또한, 일본 공개특허공보 제2002-97143호에서는 글루코사민염 또는 글루코사민 유도체가 혈전 예방 또는 혈액의 유동성을 개선시키는 것이 보고되어 있다. 그러나, 혈류 개선은 주로 혈액의 유동성에 관한 작용에 기인한 것이 대부분이며, 혈류의 개선과 동시에 혈관의 강도나 탄력성의 개선, 즉 혈관 보호 효과를 갖는 성분을 배합한 식품 또는 의약 조성물은 제공되고 있지 않다. 한편, 일본 공개특허공보 제2000-135071호에는 혈관의 강화 작용에 관해서, 와인 착즙박 추출물이 폴리페놀 함유 추출물보다 우수한 효과를 갖는 것이 개시되어 있다. 그러나 혈액의 유동성에 관해서는 아무런 검토가 실시되고 있지 않다.Therefore, a number of food and food ingredients that have the potential to improve blood flow have been reported. For example, black foods such as blackcurrant, plum pickles and the like can be cited as the near food materials. In addition, in JP-A-7-138168, it has been reported that the polar solvent extract of fish bile improves the fluidity of blood. Also, in JP-A-2002-97143, glucosamine salts or glucosamine derivatives have been reported to prevent thrombosis or to improve the fluidity of blood. However, most of the improvement of the blood flow is mainly due to the action on the fluidity of the blood, and a food or medicinal composition containing the components having blood vessel protection effect, that is, improvement of blood flow and improvement of blood vessel strength or elasticity not. On the other hand, Japanese Patent Application Laid-Open No. 2000-135071 discloses that the wine-extract paste extract has an effect superior to that of the polyphenol-containing extract in terms of blood vessel strengthening action. However, there has been no study on the fluidity of blood.

따라서, 참된 의미에서 생체내에서의 혈류의 개선, 즉 혈액의 유동성을 개선시키며, 우수한 혈관 보호 효과를 갖는 혈액유동성 개선 조성물이 요망되고 있다.
Therefore, in a true sense, there is a demand for a composition for improving blood flow in vivo, that is, improving blood flowability and having an excellent vascular protection effect.

본 발명은 상기와 같은 점들은 감안하여 발명된 것으로서, 그 목적은 혈류량을 개선함으로써 인체의 건강유지에 도움을 줄 수 있는 혈류량 개선을 위한 건강기능식품을 제공함에 있다. The present invention has been made in view of the above problems, and an object thereof is to provide a health functional food for improving blood flow which can help maintain the health of a human body by improving blood flow.

본 발명의 목적은 건강보조식품을 제조함에 있어서, 비타민A 0.134%, 비타민B1 염산염 0.027%, 비타민C 15%, 비타민E 혼합제제 1.12%, 비타민B12 0.0008%, 니코틴산아미드(나이아신) 0.32%, 황산동 0.102%, 산화마그네슘 1.7%, L-글루타민 5.55%, L-라이신염산염 5.55%, N-아세틸글루코사민 1.4%, 이노시톨 2.45%, 타우린 6.95%, 파인애플추출물분말(브로멜라인) 6.95%, 코엔자임Q10 0.84%, 케르세틴 0.7%, 옥타코사놀 0.5%, 산사자추출분말 2.28%, 포도종자추출물분말 1.6700%, 유산균발효흑마늘추출물분말 0.83%, 혼합유당(또는 유당혼합-우유, 텍스트린) 13%, 스테아린산 1.2%, 이산화규소 1.2%, 유당가수분해물분말 6%, 대두이소플라본 0.5%, 결정셀룰로오스 17.1706%, 히드록시프로필메틸셀룰로오스(HPMC) 2.1%, 글리세린지방산에스테르(Almax-5000) 0.21%, 이산화티타늄 0.7%, 치자황색소 0.2%, 비타민B6 0.009%~0.04%, 엽산 0.001%~0.007%, 파라다이스넛추출물분말(셀렌) 0.005%~0.2%, 푸르마산제일철 0.005%~0.2%, L-아르기닌 0.5%~2%, 카르복시메틸셀룰로오스 칼슘 0.5%~2%, 뽕나무잎추출분말 또는 생강추출분말 1%~2%를 포함하는 것을 특징으로 하는 혈류량 개선을 위한 건강기능식품에 의해 달성될 수 있다.
An object of the present invention in the manufacture of dietary supplements, vitamin A 0.134%, vitamin B1 hydrochloride 0.027%, vitamin C 15%, vitamin E mixture formulation 1.12%, vitamin B12 0.0008%, nicotinamide (niacin) 0.32%, copper sulfate 0.102%, magnesium oxide 1.7%, L-glutamine 5.55%, L-lysine hydrochloride 5.55%, N-acetylglucosamine 1.4%, inositol 2.45%, taurine 6.95%, pineapple extract powder (bromelain) 6.95%, coenzyme Q10 0.84 %, Quercetin 0.7%, octacosanol 0.5%, hawthorn extract powder 2.28%, grape seed extract powder 1.6700%, lactobacillus fermented black garlic extract powder 0.83%, mixed lactose (or lactose-mixed milk, textrin) 13%, stearic acid 1.2%, Silicon dioxide 1.2%, lactose hydrolyzate powder 6%, soy isoflavone 0.5%, crystalline cellulose 17.1706%, hydroxypropylmethylcellulose (HPMC) 2.1%, glycerin fatty acid ester (Almax-5000) 0.21%, titanium dioxide 0.7%, Gardenia Yellow 0.2%, Vitamin B6 0.009% ~ 0.04%, Folic Acid 0.001% ~ 0.007%, Paradise Nut Extract Powder (Selenium) 0.005% ~ 0.2%, Ferrous Fermatate 0.005% ~ 0.2%, L-Arginine 0.5% ~ 2%, Carboxymethyl Cellulose Calcium 0.5% ~ 2%, Mulberry Leaf It can be achieved by a health functional food for improving blood flow, characterized in that it comprises an extract powder or ginger extract powder 1% ~ 2%.

이상에서 살펴본 바와 같이 본 발명에 따른 혈류량 개선을 위한 건강기능식품은 다양한 활성화 물질을 포함하고 있어 복용시 혈류량을 개선함으로써 인체 건강 유지에 도움을 줄 수 있는 효과를 갖는 것이다.
As described above, the health functional food for improving blood flow according to the present invention contains various activating substances and has an effect of helping to maintain human health by improving blood flow during taking.

도 1은 실시예 1에 따른 혈류량 변화를 나타내는 그래프
도 2는 실시예 2에 따른 혈류량 변화를 나타내는 그래프
도 3은 실시예 3에 따른 혈류량 변화를 나타내는 그래프
1 is a graph showing changes in blood flow volume according to Example 1
2 is a graph showing changes in blood flow volume according to Example 2
Fig. 3 is a graph showing changes in blood flow volume according to the third embodiment

이하에서는 본 발명의 바람직한 실시예를 보다 구체적으로 살펴본다.Hereinafter, preferred embodiments of the present invention will be described in more detail.

이하의 실시예에서 나타나는 y 는 해당성분이 포함된 것을 의미하고, 공란은 포함하지 않고 있음을 의미한다. In the following examples, y means that the corresponding component is included, and does not include a blank.

도 1 내지 도 3에는 각각의 실시예에 따라 제조된 건강식품을 섭취한 후의 시간 흐름에 따른 혈류량 변화를 나타내고 있다.
1 to 3 show changes in blood flow over time after ingesting the health food prepared according to each embodiment.

실시예 1에는 아래의 표 1과 같은 성분으로 식품을 구성하였다. In Example 1, food was composed of the ingredients shown in Table 1 below.

성 분ingredient 비율(%)ratio(%) 건강추출물분말Health extract powder yy 건조효모(Cr 0.2%)Dry Yeast (Cr 0.2%)   건조효모(Se 0.1%)Dry Yeast (Se 0.1%)   결정셀룰로오스Crystalline cellulose 17.1706 17.1706 글리세린지방산에스테르Glycerin Fatty Acid Ester 0.210.21 니코틴산아미드Nicotinic acid amide 0.320.32 단백질분해효소Protease   대두추출물분말(소이플라본)Soybean extract powder (soy isoflavone) yy 덱스트린dextrin   두나리엘라추출물분말Dunaeria extract powder   베타카로틴(10%)Beta Carotene (10%)   비타민 B2(Riboflavine)Vitamin B2 (Riboflavine)   비타민A 혼합제제Vitamin A mixed preparation yy 비타민B1 염산염Vitamin B1 hydrochloride 0.0270.027 비타민B12Vitamin B12 0.0008 0.0008 비타민B6 염산염Vitamin B6 hydrochloride yy 비타민CVitamin C 1515 비타민E 혼합제제Vitamin E mixed preparation 1.121.12 산사자추출분말(고형분 70%)Hawthorn Extract Powder (70% solids) yy 산화마그네슘Magnesium oxide 1.71.7 스테아린산Stearic acid 1.21.2 염화칼륨Potassium chloride   엽산Folic acid 0.0066 0.0066 옥타코사놀(1%)Octacosanol (1%) yy 유당가수분해물분말Lactose hydrolyzate powder yy 유산균발효흑마늘추출물분말Lactic acid fermented black garlic extract powder yy 이노시톨Inositol yy 이산화규소Silicon dioxide 1.21.2 이산화티타늄( TiO₂)Titanium dioxide (TiO₂) yy 철(인산)Iron (phosphoric acid)   철(젖산)Iron (lactic acid)   치자황색소Gardenia yellow yy 카르복시메틸셀룰로오스 칼슘(CMC Ca)Carboxymethylcellulose calcium (CMC Ca) yy 케르세틴Quercetin yy 코엔자임 Q10Coenzyme Q10 yy 타우린Taurine yy 파라다이스넛Paradise nuts yy 파인애플추출물분말 (브로멜라인)Pineapple extract powder (bromelain) yy 판토텐산칼슘Calcium Pantothenate   포도종자추출물분말Grape seed extract powder yy 푸르마산제일철Furma-san Cheil Iron yy 혼합유당Mixed lactose yy 홍삼농축액분말Red ginseng concentrate powder   황산동Copper sulfate yy 히드록시프로필메틸셀룰로오스( HPMC )Hydroxypropylmethylcellulose (HPMC) yy L-글루타민L-glutamine yy L-라이신염산염L-lysine hydrochloride yy L-아르기닌L-arginine yy N-아세틸글루코사민N-acetylglucosamine yy 중량weight 1000mg1000 mg

도 1은 실시예 1에 따라 제조된 식품을 정제로 하여 1000mg 2알을 섭취한 경우의 1일 차 내지 4일 차의 혈류량 변화를 나타내고 있다. 그래프에 나타난 바와 같이 식품을 섭취하지 않은 경우 새벽 시간에 혈류량이 약 13000μ㎥/s 정도로 비교적 높게 유지하다가 아침시간이 되면서 급격하게 저하되고 있는 반면 실시예 1에 따른 식품을 섭취한 경우 1일 차에는 오후 7시경을 지나면서 혈류가 급격하게 상승하고 있고, 2일 차에는 오후 2시경으로 혈류상승 개시 시간이 당겨졌으며, 4일 차에는 오후 3시경에 상승하는 것은 물론 상승량도 25000μ㎥/s 로 매우 높게 나타나고 있다.
Fig. 1 shows changes in the blood flow of day 1 to day 4 when two tablets of 1000 mg were taken as tablets from the food prepared according to Example 1. Fig. As shown in the graph, when the food was not consumed, the blood flow was maintained at a relatively high level of about 13000 占 / / s at the dawn time, and then rapidly dropped in the morning time. On the other hand, when the food according to Example 1 was consumed, The blood flow increased rapidly around 7:00 pm, and the start time of the blood flow rise was pulled around 2:00 pm on the 2nd day. On the 4th day, it rose to around 3:00 pm and the rise amount was 25000μ㎥ / s. Respectively.

실시예 2는 아래의 표 2과 같은 성분으로 식품을 구성하였다. Example 2 constituted food with the ingredients shown in Table 2 below.

성 분ingredient 비율(%)ratio(%) 건강추출물분말Health extract powder   건조효모(Cr 0.2%)Dry Yeast (Cr 0.2%) yy 건조효모(Se 0.1%)Dry Yeast (Se 0.1%) yy 결정셀룰로오스Crystalline cellulose 14.514.5 글리세린지방산에스테르Glycerin Fatty Acid Ester 0.150.15 니코틴산아미드Nicotinic acid amide 4.64.6 단백질분해효소Protease yy 대두추출물분말(소이플라본)Soybean extract powder (soy isoflavone) yy 덱스트린dextrin   두나리엘라추출물분말Dunaeria extract powder   베타카로틴(10%)Beta Carotene (10%) yy 비타민 B2(Riboflavine)Vitamin B2 (Riboflavine) yy 비타민A 혼합제제Vitamin A mixed preparation   비타민B1 염산염Vitamin B1 hydrochloride 2.82.8 비타민B12Vitamin B12 0.020.02 비타민B6 염산염Vitamin B6 hydrochloride y y 비타민CVitamin C 3232 비타민E 혼합제제Vitamin E mixed preparation 66 산사자추출분말(고형분 70%)Hawthorn Extract Powder (70% solids)   산화마그네슘Magnesium oxide 22 스테아린산Stearic acid 1One 염화칼륨Potassium chloride yy 엽산Folic acid 0.0150.015 옥타코사놀(1%)Octacosanol (1%)   유당가수분해물분말Lactose hydrolyzate powder yy 유산균발효흑마늘추출물분말Lactic acid fermented black garlic extract powder   이노시톨Inositol   이산화규소Silicon dioxide 0.50.5 이산화티타늄( TiO₂)Titanium dioxide (TiO₂) yy 철(인산)Iron (phosphoric acid) yy 철(젖산)Iron (lactic acid)   치자황색소Gardenia yellow   카르복시메틸셀룰로오스 칼슘(CMC Ca)Carboxymethylcellulose calcium (CMC Ca)   케르세틴Quercetin   코엔자임 Q10Coenzyme Q10 yy 타우린Taurine   파라다이스넛Paradise nuts   파인애플추출물분말 (브로멜라인)Pineapple extract powder (bromelain)   판토텐산칼슘Calcium Pantothenate yy 포도종자추출물분말Grape seed extract powder yy 푸르마산제일철Furma-san Cheil Iron   혼합유당Mixed lactose   홍삼농축액분말Red ginseng concentrate powder yy 황산동Copper sulfate   히드록시프로필메틸셀룰로오스( HPMC )Hydroxypropylmethylcellulose (HPMC) yy L-글루타민L-glutamine yy L-라이신염산염L-lysine hydrochloride   L-아르기닌L-arginine yy N-아세틸글루코사민N-acetylglucosamine yy 중량weight 650mg650 mg

도 2에는 실시예 2에 따라 제조된 식품을 정제로 하여 650mg 2알을 섭취한 경우의 1일 차 내지 5일 차의 혈류량 변화를 나타내고 있다.FIG. 2 shows changes in the blood flow of day 1 to day 5 when the food prepared according to Example 2 is taken as tablets and two tablets of 650 mg are ingested.

그래프에 나타난 바와 같이 실시예 2에 따른 식품을 섭취한 경우 1일차에는 오후 2시경을 지나면서 혈류가 급격하게 상승하고 있고, 4일 차 및 5일 차에는 오전 11시경을 전후하여 혈류가 상승하여 약 18000~20000μ㎥/s 로 매우 높게 나타나고 있다.
As shown in the graph, when the food according to Example 2 was consumed, the blood flow rapidly increased after about 2:00 pm on the first day, and the blood flow increased around 11:00 am on the fourth and fifth day It is very high, about 18000 ~ 20000m3 / s.

실시예 3은 아래의 표 3과 같은 성분으로 식품을 구성하였다. Example 3 was composed of the ingredients shown in Table 3 below.

성 분ingredient 비율(%)ratio(%) 건강추출물분말Health extract powder   건조효모(Cr 0.2%)Dry Yeast (Cr 0.2%) yy 건조효모(Se 0.1%)Dry Yeast (Se 0.1%)   결정셀룰로오스Crystalline cellulose 2626 글리세린지방산에스테르Glycerin Fatty Acid Ester 0.10.1 니코틴산아미드Nicotinic acid amide 8.88.8 단백질분해효소Protease   대두추출물분말(소이플라본)Soybean extract powder (soy isoflavone)   덱스트린dextrin yy 두나리엘라추출물분말Dunaeria extract powder yy 베타카로틴(10%)Beta Carotene (10%)   비타민 B2(Riboflavine)Vitamin B2 (Riboflavine)   비타민A 혼합제제Vitamin A mixed preparation   비타민B1 염산염Vitamin B1 hydrochloride 1.21.2 비타민B12Vitamin B12 0.010.01 비타민B6 염산염Vitamin B6 hydrochloride  yy 비타민CVitamin C 17.117.1 비타민E 혼합제제Vitamin E mixed preparation 20.920.9 산사자추출분말(고형분 70%)Hawthorn Extract Powder (70% solids)   산화마그네슘Magnesium oxide 7.47.4 스테아린산Stearic acid 0.80.8 염화칼륨Potassium chloride yy 엽산Folic acid 0.0080.008 옥타코사놀(1%)Octacosanol (1%)   유당가수분해물분말Lactose hydrolyzate powder   유산균발효흑마늘추출물분말Lactic acid fermented black garlic extract powder   이노시톨Inositol   이산화규소Silicon dioxide 0.80.8 이산화티타늄( TiO₂)Titanium dioxide (TiO₂)   철(인산)Iron (phosphoric acid)   철(젖산)Iron (lactic acid) yy 치자황색소Gardenia yellow   카르복시메틸셀룰로오스 칼슘(CMC Ca)Carboxymethylcellulose calcium (CMC Ca)   케르세틴Quercetin   코엔자임 Q10Coenzyme Q10   타우린Taurine   파라다이스넛Paradise nuts yy 파인애플추출물분말 (브로멜라인)Pineapple extract powder (bromelain)   판토텐산칼슘Calcium Pantothenate   포도종자추출물분말Grape seed extract powder   푸르마산제일철Furma-san Cheil Iron   혼합유당Mixed lactose   홍삼농축액분말Red ginseng concentrate powder   황산동Copper sulfate yy 히드록시프로필메틸셀룰로오스( HPMC )Hydroxypropylmethylcellulose (HPMC) yy L-글루타민L-glutamine   L-라이신염산염L-lysine hydrochloride   L-아르기닌L-arginine   N-아세틸글루코사민N-acetylglucosamine  yy 중량weight 1000mg1000 mg

도 3에는 실시예 3에 따라 제조된 식품을 정제로하여 1000mg 2알을 섭취 한경우의 1일 차 및 2일 차의 혈류량 변화를 나타내고 있다.FIG. 3 shows changes in blood flow on day 1 and day 2 when two tablets of 1000 mg were taken as tablets from the food prepared according to Example 3. FIG.

그래프에 나타난 바와 같이 실시예 2에 따른 식품을 섭취한 경우 1일 차에는 오후 3시경을 지나면서 혈류가 상승하여 약 13000μ㎥/s를 유지하고 있으며, 2일 차에는 오후 5시경에 혈류가 약 20000μ㎥/s 까지 매우 높게 상승하는 것을 알 수 있다.As shown in the graph, when the food according to Example 2 was consumed, the blood flow increased to about 13000 mu m < 3 > / s after about 3 pm in the tea on day 1, It can be seen that it rises very high up to 20000 mu m < 3 > / s.

Claims (1)

건강보조식품을 제조함에 있어서, 비타민A 0.134%, 비타민B1 염산염 0.027%, 비타민C 15%, 비타민E 혼합제제 1.12%, 비타민B12 0.0008%, 니코틴산아미드(나이아신) 0.32%, 황산동 0.102%, 산화마그네슘 1.7%, L-글루타민 5.55%, L-라이신염산염 5.55%, N-아세틸글루코사민 1.4%, 이노시톨 2.45%, 타우린 6.95%, 파인애플 추출물분말(브로멜라인) 6.95%, 코엔자임Q10 0.84%, 케르세틴 0.7%, 옥타코사놀 0.5%, 산사자추출분말 2.28%, 포도종자 추출물분말 1.6700%, 유산균발효 흑마늘 추출물분말 0.83%, 혼합유당(또는 유당혼합-우유, 텍스트린) 13%, 스테아린산 1.2%, 이산화규소 1.2%, 유당가수분해물분말 6%, 대두이소플라본 0.5%, 결정셀룰로오스 17.1706%, 히드록시프로필메틸셀룰로오스(HPMC) 2.1%, 글리세린지방산에스테르(Almax-5000) 0.21%, 이산화티타늄 0.7%, 치자황색소 0.2%, 비타민B6 0.009%~0.04%, 엽산 0.001%~0.007%, 파라다이스넛추출물분말(셀렌) 0.005%~0.2%, 푸르마산제일철 0.005%~0.2%, L-아르기닌 0.5%~2%, 카르복시메틸셀룰로오스 칼슘 0.5%~2%, 뽕나무잎추출분말 또는 생강추출분말 1%~2%를 포함하는 것을 특징으로 하는 혈류량 개선을 위한 건강기능식품

In preparing health supplements, vitamin A 0.134%, vitamin B1 hydrochloride 0.027%, vitamin C 15%, vitamin E mixture formulation 1.12%, vitamin B12 0.0008%, nicotinic acid amide (niacin) 0.32%, copper sulfate 0.102%, magnesium oxide 1.7%, L-glutamine 5.55%, L-lysine hydrochloride 5.55%, N-acetylglucosamine 1.4%, inositol 2.45%, taurine 6.95%, pineapple extract powder (bromelain) 6.95%, coenzyme Q10 0.84%, quercetin 0.7% , Octacosanol 0.5%, mountain lion extract powder 2.28%, grape seed extract powder 1.6700%, lactic acid bacteria fermented black garlic extract powder 0.83%, mixed lactose (or lactose mixed-milk, textrin) 13%, stearic acid 1.2%, silicon dioxide 1.2%, Lactose hydrolyzate powder 6%, soy isoflavone 0.5%, crystalline cellulose 17.1706%, hydroxypropyl methyl cellulose (HPMC) 2.1%, glycerin fatty acid ester (Almax-5000) 0.21%, titanium dioxide 0.7%, gardenia yellow 0.2% , Vitamin B6 0.009% ~ 0.04%, Folic acid 0.001% ~ 0.007% , Paradise Nut Extract Powder (Selenium) 0.005% ~ 0.2%, Ferrous Fermatate 0.005% ~ 0.2%, L-Arginine 0.5% ~ 2%, Carboxymethyl Cellulose Calcium 0.5% ~ 2%, Mulberry Leaf Extract Powder or Ginger Extract Powder Health functional food for improving blood flow, comprising 1% to 2%

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