KR20160022172A - Composition for improving male health - Google Patents

Abstract

The present invention relates to a composition for improving male health, a food composition including the composition for improving male health, and a pharmaceutical composition including the composition for improving male health. The composition for improving male health comprises a Tribulus terrestris L. extract, Maka extract, a red ginseng extract, a Rosa multiflora Thunberg extract, and a beetroot extract. The composition can improve male sexual function and relieve andropause symptoms.

Description

COMPOSITION FOR IMPROVING MALE HEALTH [0002]

The present disclosure relates to a composition for enhancing male health, a food composition comprising the composition, and a pharmaceutical composition comprising the composition.

Symptoms caused by a decrease in male hormones in more than 50 males appear worldwide, with a reported rate of about 0.5%. Examples of such symptoms include sexual desire, decreased foot function, increased fatigue, decreased vitality, decreased muscle mass and increased body fat, depression, and male osteoporosis. As a countermeasure against the above symptoms, male hormone replacement therapy is used, and medicines (Viagra, Cialis) and health foods containing red ginseng and maca are used for improving the symptoms of erectile dysfunction.

However, the use of hormone replacement therapy and erectile dysfunction drugs may have side effects such as liver function, cardiovascular disease, and prostate health, and health foods containing red ginseng, maca, etc. have limited effectiveness.

Korean Patent Laid-Open Publication No. 2014-0019685

The present disclosure provides compositions for improving male sexual function or for relieving menopausal symptoms.

The present disclosure provides a composition comprising a male mussel extract, a maca mussel extract, a red ginseng extract, a ginseng extract, and a bitter root extract.

The present invention also provides a food composition comprising the composition.

Finally, the present disclosure provides a pharmaceutical composition comprising the composition.

The composition herein has the effect of improving male sexual function.

In addition, the composition is effective in alleviating male menopausal symptoms.

Hereinafter, the present invention will be described in more detail.

The present disclosure provides a composition comprising a male mussel extract, a maca mussel extract, a red ginseng extract, a ginseng extract, and a bitter root extract.

The above Nambala extract is an extract of Tribulus terrestris fruit. It is an annual plant that grows in sandy beaches and is distributed in Korea, India and Taiwan. The southern trout contains saponin, essential oil, alkaloids, resin, oil component and campferol. The Dong-bo-gyu sense describes the use of a male saddlebag, such as a hemiplegic medicine, kidney protection, eye disease, diuretic, headache and menstrual irregularities.

The above-mentioned maca extract is an extract of Maka.

Maca is called a "wild ginseng of Peru" and is a cruciferous plant that grows in harsh conditions in the 4000-meter range of the Peruvian Andes. Maca has been used since the ancient Inca era for malnutrition, memory recovery, arthritis, respiratory diseases, diabetes, and tinnitus. Maca is known to be effective not only in male sexual function, but also in sexual hormone regulation, vitality enhancement, anemia, and menopausal syndrome in women.

The red ginseng extract is an extract of red ginseng. The red ginseng has various physiological activity functions such as fatigue recovery, immunity enhancement, blood circulation improvement, and memory improvement. In particular, the saponin component liberates nitrogen oxide (Nitric Oxide) to allow antioxidative action. In addition, it has been reported that nitrogen monoxide acts on muscle relaxation of male reproductive tissues.

The Rosa multiflora Thunberg extract is an extract of Rosa multiflora, a berry fruit. The Lactuca sativa extract contains 0.6-0.8% of ruthenium, quercetin and camphorol as multi-florin, Rhamnoglucoside of quercetin. The hypochlorite contains vitamin P active substance, and is also used as insomnia, forgetfulness, swelling / species and female physiological impairment, diuretic in one room.

The Beetroot extract is an extract of Beetroot, the beetroot being edible and being consumed in salads or as a meal. Beet has a unique red pigment (betalain), so it is used as a natural pigment in textiles, cosmetics and foods. It also contains rich nutrients such as magnesium, sodium, potassium, and vitamin C and powerful antioxidants, which is beneficial for cardiovascular health.

In one embodiment, the composition further comprises an additive.

Wherein the additive is selected from the group consisting of vitamin A, B, C, E, biotin, folic acid, niacin, calcium, zinc, selenium, mineral components, amino acids, soybean oil, emulsifiers, sweeteners, flavors, preservatives, But it is not limited thereto. The additive may further include those commonly used in the art.

The vitamin B may be at least one selected from the group consisting of B1, B2 and B6.

The sweetener may be at least one selected from the group consisting of honey, oligosaccharide, and fruit concentrate.

In one embodiment, the total amount of the composition is 0.01 to 10% by weight, the maca extract is 0.01 to 10% by weight, the red ginseng extract is 0.01 to 10% by weight, The extract may comprise from 0.01% to 10% by weight, the bitrooted extract from 0.005% to 10% by weight and the additive from 50% to 98% by weight.

If the above Nambala extract, Maca extract, Red ginseng extract, Glycyrrhiza extract and Bitroot extract are contained in the lower limit of the above-mentioned range, the effect of the composition is not sufficient. Also, if it is included in a high content, the effect of the composition does not increase, and the physical properties, color and specific flavor of the main component itself may affect the product containing the composition.

Accordingly, the total amount of the composition is 0.5 to 3 wt%, the macaca extract is 0.1 to 4.0 wt%, the red ginseng extract is 0.1 to 2 wt%, the ginseng extract is 0.02 By weight to 0.5% by weight of the bitter root extract and 0.01% to 0.5% by weight of the bitter root extract.

In one embodiment, the use of the composition according to the present invention is for improving male sexual function.

In one embodiment, the use of the composition according to the present invention is for alleviating male menopausal symptoms.

The composition according to the present invention can ameliorate weakened male sexual functions, such as sexual arousal and foot dysfunction, caused by reduced male sex hormones in men over 50 years. In addition, the composition according to the present invention can be used for alleviating menopausal symptoms such as fatigue, decreased vitality, decreased muscle mass, increased body fat, depression and osteoporosis.

One embodiment of the present disclosure provides a food composition comprising the composition described above.

Another embodiment of the present disclosure provides a pharmaceutical composition comprising the composition described above.

The food composition may mean a composition capable of ingestible food including beverage.

The pharmaceutical composition may mean a composition capable of ingesting for the prevention or treatment of male sexual function or menopausal disease.

The formulations of the food composition or pharmaceutical composition may be beverage, jelly, extract, capsule, tablet, ring, granule, liquid or powder, and the particular formulations are not intended to be limited to a composition according to one embodiment of the present disclosure .

In addition, the composition may further include an additive containing various components commonly used in the art depending on the formulation.

<Experimental Example>

1. Preparation of components

The Nambala extract was obtained by obtaining the dried matter of fruit, removing the foreign matter, and crushed, and then measuring the raw material. The weighed raw material is put into a tank, and then purified water of 10 times of the raw material is poured therein, followed by extraction at 120 ° C for 4 hours. Subsequently, the mixture was filtered with diatomaceous earth, concentrated under reduced pressure to obtain 15 Brix, and sterilized and packed at 85 DEG C for 20 minutes.

The maca extracts were obtained from maca powder and the foreign materials were removed and the raw materials were quantified. After the metered raw materials were put into a tank, 7 times as much purified water as that of the raw material was poured into the tank and enzymatically decomposed with? -Amylase. The enzyme degradation product obtained by the enzymatic degradation was cooled, and then concentrated under reduced pressure to obtain 60 Bricks. The mixture was then heated at 85 캜 for 30 minutes to sterilize the concentrate.

Red ginseng extract was purchased from Hanil Ginseng Industry Co., Ltd., and the liquid product was used with a solid content of 65% or more.

Extracts of Liliaceae were obtained from dried berry berry and weighed the raw materials. The metered raw materials were put into a tank, poured into 10 times as much purified water as the raw material, and extracted by the same method as that of the maca extract at 120 DEG C for 4 hours. In the experimental example, a solid content of 13% or more was used.

The maca, southern greens, and ginseng extract were purchased from Samyoung Foods.

Bitter root extract was purchased from Sabinsa Korea Corporation and used. The bittern root extract is standardized to have a nitrate content of 2.0% as a raw material after adding the dextrin to the root portion of the bit route and pulverizing it.

2. Preparation of mixture

Namhaega extract, maca extract, red ginseng extract, royal ginseng extract and bittern root extract were mixed according to the content ratios shown in Table 1 below.

Swordfish
extract Maca
extract Red ginseng
extract Livelier
extract Bitroot
extract Test Example 1 1.2 - - - - Test Example 2 - 1.6 - - - Test Example 3 - - 0.1 - - Test Example 4 - - - 0.2 - Test Example 5 - - - - 0.1 Test Example 6 1.0 1.5 - - - Test Example 7 1.0 - 0.1 - - Test Example 8 1.0 - - 0.2 - Test Example 9 1.0 - - - 0.1 Test Example 10 1.0 1.5 0.1 - - Test Example 11 1.0 1.5 0.1 0.2 - Test Example 12 1.0 1.5 0.1 0.2 0.1 Test Example 13 1.0 1.5 0.1 0.05 0.1 Test Example 14 0.8 0.4 0.1 0.05 0.05

(Unit: wt%)

3. Experimental Example - Measurement of antioxidant efficacy

The abnormalities of free radicals or antioxidant enzymes in the male reproductive tissues may also cause erectile dysfunction, and materials with antioxidant activity are related to the effects of fatigue and vitality associated with erectile dysfunction and other oxidative stimuli . In order to confirm the above facts, antioxidant efficacy was measured for Test Examples 1 to 14 in Table 1. DPPH (1,1-diphenyl-2-picryl hydrazyl) was tested for antioxidant activity. Test Examples 1 to 14 were diluted at an appropriate ratio, and 100 μl of each sample was added to each well of a 96-well plate. Then, 100 μl of 0.035% DPPH solution was added. After standing at room temperature for 30 minutes, the absorbance was measured at 517 nm. Subsequently, the inhibition rate of DPPH was determined by the following formula, and it is shown in [Table 2]. The higher DPPH inhibition value is, the better the antioxidant effect is. Therefore, it can be seen that the antioxidant efficacy of Test Example 12 is excellent.

 * DPPH inhibition = (1 - absorbance of the example) / solvent control (distilled water) absorbance * 100

Test Example 1 Test Example 2 Test Example 3 Test Example 4 Test Example 5 Test Example 6 Test Example 7 DPPH inhibition rate 70.6 65.6 50.7 70.9 76.9 85.0 75.6 Test Example 8 Test Example 9 Test Example 10 Test Example 11 Test Example 12 Test Example 13 Test Example 14 DPPH inhibition rate 76.5 80.9 87.8 94.9 98.4. 90.5 88.7

(unit : %)

4. Experimental Example - Measuring Male Menopausal Improvement Efficacy

100 ml of a drink was prepared by adding an additive to Test Example 12, which contained 1.0% by weight of the southern root extract, 1.5% by weight of maca extract, 0.1% by weight of red ginseng extract, 0.2% by weight of royal ginseng extract and 0.1% by weight of bitter root extract. Then, the drink prepared by drinking the above-mentioned beverage was menstruated to men over 45 years old, and then the menopausal period improvement effect was confirmed. The ADAM (Androgen Deficiency for Aging Male) questionnaire was used as a method to diagnose male menopausal symptoms. The questionnaire was appropriately modified and used in accordance with the product development direction of the beverage composition according to the present invention. The detailed questionnaire items are shown in [Table 3].

Question Number Question Score scale One Energy level during daily life (energy level) point 2 Happiness index, change of degree of pleasure of life
(happiness, enjoyment of life) point 3 Change in work performance point 4 The number of times you sleep immediately after dinner
(falling asleep after dinner) point 5 Libido change point 6 Changes in erectile strength (erection strength) point 7 Sexual endurance / endurance
(erection maintainance / endurance during intercourse) point

The male volunteers above 45 years old were allowed to drink the above-prepared beverages daily for 10 days, two to three hours before going to bed, and then compared with before drinking the beverage, the questionnaire items of Table 3 Of the respondents were asked to respond with a 5 - point scale. The criteria of the scoring scale are as follows.

Table 4 shows the number of respondents with 4 points or more for each item for the same male volunteers. As a comparative example 1, a competitor (company C) product currently sold with similar functionality was used.

* Score scale: 5 points (increase or improve), 4 points (decrease or increase), 3 points (change or no change), 2 points (decrease or deteriorate)

Question Number One 2 3 4 5 6 7 Test Example 12 3 4 3 3 4 6 6 Comparative Example 1 4 5 4 3 3 5 5

From Table 4, it can be seen that by drinking a drink containing the composition according to the present invention, the erectile strength of a large number of male volunteers is strengthened. In addition, it can be seen that the erectile durability / endurance is improved in the sex life. In the case of Test Example 12, it can be confirmed that Surveys 5 to 7, which are related to sexual function-related effects, are superior to those of Comparative Example 1.

&Lt; Example 1 >

As described above, raw materials were prepared in the contents of the following Table 5 using the sweetener, flavor, preservative, acidity regulator, thickener, gugija extract, and the like, which are included as main components in Test Example 12 and are commonly used additives for beverages . The raw materials in the following Table 5 were uniformly mixed in distilled water using a high-speed stirrer. Then, after sterilization at high temperature, the beverage was prepared by injection into bottles or cans.

Raw material name Content (% by weight) South Male Extract 1.0 Maca extract 1.5 Red ginseng extract 0.1 Lily Extract 0.2 Bitroot extract 0.1 Gugija extract 0.15 Vitamin B1 0.0003 Flavor Suitable amount Acidity control agent Suitable amount Distilled water Up to (sum) 100.00

&Lt; Example 2 &

Ingredients were prepared in the amounts shown in Table 6 below using sweeteners, flavors, preservatives, acidity regulators, thickeners, and horn extracts, which are commonly used additives in beverages. The raw materials in Table 6 were uniformly mixed in distilled water using a high-speed stirrer. Then, the mixture was filled in a polyethylene bag and retorted to prepare a pouch concentrate.

Raw material name Content (% by weight) South Male Extract 3 Maca extract 3 Red ginseng extract 0.5 Lily Extract 5 Bitroot extract 0.3 Hounsu extract 0.2 Vitamin B2 0.0003 Vitamin B6 0.0003 oligosaccharide Suitable amount Fruit concentrate Suitable amount honey Suitable amount Distilled water Up to (sum) 100.00

The above-mentioned Product Examples 1 and 2 are merely examples for producing a conventional liquid product including the composition for enhancing male health according to the present invention, and are not intended to limit the formulations and raw materials of the present invention.

Claims (7)

Manganese extract, red ginseng extract, ginseng extract, and Bitroot extract. The method according to claim 1,
Wherein the composition is selected from the group consisting of vitamin A, B, C, E, biotin, folic acid, niacin, calcium, zinc, selenium, mineral components, amino acids, soybean oil, emulsifiers, sweeteners, flavors, preservatives, Wherein the composition further comprises one or more additives selected. The method of claim 2,
Wherein the extract of Namulah is 0.01 wt% to 10 wt% with respect to the total amount of the composition, the extract of Macaca is 0.01 wt% to 10 wt% with respect to the total amount of the composition, the red ginseng extract is 0.01 wt% to 10 wt% Wherein the bittern root extract is from 0.005% to 10% by weight based on the total amount of the composition and the additive is from 50% to 70% by weight based on the total amount of the composition. . The method according to claim 1,
Wherein said composition is for improving male sexual function. The method according to claim 1,
Wherein the composition is for alleviating male menopausal symptoms. A food composition comprising the composition according to any one of claims 1 to 5. A pharmaceutical composition comprising the composition according to any one of claims 1 to 5.