CN106820127A - Selenium-rich natto fine powder and preparation method thereof - Google Patents
Selenium-rich natto fine powder and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of selenium-rich natto fine powder, including following components represented with weight portion：30 42 parts of selenium-rich natto powder, 25 32 parts of pineapple powder, 10 16 parts of apple powder, 11 15 parts of konjaku flour.The method for making the selenium-rich natto fine powder：121 DEG C of the selenium-rich soya bean boiling 22 30 minutes after dipping in water of selenium-rich soya bean, 40 DEG C are cooled to after boiling, bafillus natto is inoculated with by 1% 5% inoculum concentration, fermented in the selenium-rich soya bean propulsion fermenting cellar that will be inoculated with, 0 DEG C is then placed in place 12 hours, natto is freeze-dried to remove moisture removal, with pulverizer preliminary crushing to 60 mesh, crushed with ultramicro grinding homogenizer again, cross 180 mesh vibratory sieves and natto powder is obtained, by selenium-rich natto powder, pineapple powder, apple powder, konjaku flour is placed in Multidimensionblender and mixes 20 30 minutes, temperature control is at 38 DEG C, then through 38 DEG C of dehumidifiers, dry, it is made selenium-rich natto fine powder.The selenium-rich natto fine powder is capable of the recurrence of thrombus always while have a good thrombolytic effect to a certain extent.
Description
Technical field
The present invention relates to healthy food manufacture field, in particular, it is related to a kind of selenium-rich natto fine powder and its making
Method.
Background technology
With the improvement of people ' s living standards, the change of dietary structure, cardiovascular and cerebrovascular disease has become the harm mankind and is good for
One of health most serious and most common disease, it is very harmful especially for the elderly.Cardiovascular and cerebrovascular disease has " morbidity
Rate is high, disability rate is high, the death rate is high, high recurrence rate, complication are more " the features such as.At present, China's Patients with Cardiovascular/Cerebrovascular Diseases has surpassed
2.7 hundred million people, China dies from nearly 3,000,000 people of cardiovascular and cerebrovascular disease every year, and the harm of embolism class diseases is particularly in cardiovascular and cerebrovascular disease
Seriously.
Natto is initiated by China and is popular in the traditional food of Japan, is through natto gemma bar from high-quality selenium-rich soya bean
Bacterium fermentation is formed.Natto have viscosity, not only possess selenium-rich soya bean nutritive value, rich in vitamin K, protein can be improved
Digestibility, it is often more important that fermentation process generates several physiological active substances, most important of which is that have thrombolysis
The Nattokinase of effect.Nattokinase be secreted into by bafillus natto it is extracellular a kind of with strong fibrinolytic serine egg
White enzyme, can effectively dissolve the important substance-insoluble fibrin of composition vascular wall patch, with powerful dissolving patch and blood
Bolt is acted on.
Eat the launch such as natto, Nattokinase, bean-containing capsule in existing market raw, this kind of product be mainly according to
Dissolving patch and thrombus effect are played by the speciality of Nattokinase autolysis insoluble fibrin, and these are established
Patch and thrombus, certain damage has been had resulted in vascular wall, and after they are dissolved, the position exposure that these are damaged,
So that the lipid in blood is easily accessible vascular wall, it is deposited on that blood vessel is subcutaneous, forms new patch and thrombus so as to cause to stop
Easily recurrence after taking.
The content of the invention
It is an object of the invention to provide a kind of selenium-rich natto fine powder and preparation method thereof, the selenium-rich natto fine powder has good
The recurrence of thrombus can be suppressed while the thrombolytic effect got well to a certain extent.
To achieve the above object, the invention provides following technical scheme：
A kind of selenium-rich natto fine powder, including following components represented with weight portion：30-42 parts of selenium-rich natto powder, pineapple powder 25-32
Part, apple powder 10-16 parts, konjaku flour 11-15 parts.
Organic Selenium is rich in wherein in selenium-rich natto powder, it is easy to absorption of human body, and blood inner lipid can be removed and be oxidized
The free radical for producing afterwards, suppresses the biosynthesis of internal cholesterol, and reduces the quantity and size of the formation of patch and thrombus, from
And mitigate the amount of thrombus needed for Nattokinase, and substantial amounts of flavonoids and pectin being contained in fruit powder, can promote to be swashed by natto
The thrombus that enzyme is dissolved metabolic adsorption in vivo.The free radical produced after blood inner lipid is oxidized in metabolic process is by tomato
Lycopene is removed in powder, so as to suppress the biosynthesis of internal cholesterol simultaneously in vivo in the thrombus discharge for accelerating to be dissolved,
The effect for suppressing recurrence of thrombus is further functioned as while enhancing thrombolysis Scavenging activity.Natural mannosan in konjaku and
Gelatinous mass interacts with pectin and layer protecting film can be formed in alimentary canal, and suppresses the absorption of fat in alimentary canal,
Suppress cholesterol, reducing blood lipid so as to play a part of to reduce, so as to play a part of to suppress recurrence of thrombus.
Preferably, described selenium-rich natto fine powder, including following components represented with weight portion：Selenium-rich natto powder 35
Part, 28 parts of pineapple powder, 14 parts of apple powder, 13 parts of konjaku flour.
A kind of method for making selenium-rich natto fine powder, comprises the following steps：
Step 1：Selenium-rich soya bean is impregnated in water, 5-8 DEG C impregnates 12-28 hours；
Step 2：By selenium-rich soya bean be placed in high steam pot in, 121 DEG C boiling 22-30 minutes；
Step 3：Selenium-rich soya bean after boiling is cooled to 40 DEG C, the inoculum concentration of 1%-5% is pressed by the way of spraying, inoculation is received
Beans bacillus；
Step 4：Fermented in the selenium-rich soya bean propulsion fermenting cellar that will be inoculated with, fermentation temperature is 35-39 DEG C, and relative humidity is maintained at
85%-100%, fermentation can obtain fresh natto in 24 hours；
Step 5：The fresh natto that will be fermented is placed in 0 DEG C and places 12 hours, and selenium-rich natto is obtained；
Step 6：In step 5 produce natto it is freeze-dried removes moisture removal, first with pulverizer preliminary crushing to 60 mesh, then with surpass
Micro-disintegrating homogenizer is crushed, and crosses 180 mesh vibratory sieves and selenium-rich natto powder is obtained；
Step 7：Selenium-rich natto powder, pineapple powder, apple powder, konjaku flour are placed in Multidimensionblender and are mixed 20-30 minutes, temperature
Control, then through 38 DEG C of dehumidifiers, is dried at 38 DEG C, is made selenium-rich natto fine powder.
Natto surface after being fermented wherein in step 4 forms one layer of tunica albuginea, and tacky, wire drawing is more long, gained natto color
Jaundice, there is metallic luster, and because Nattokinase is primarily present in the sticky wire drawing of natto, thus increases to a certain extent
The content of Nattokinase, and the fresh natto that will be fermented in step 5 is placed in 0 DEG C and places 12 hours, advantageously ensures that natto
Kinases has good activity.
Further, it is made battalion to addition sodium selenite, magnesium sulfate, sodium chloride and chromium chloride in the water in the step 1
Nutrient solution, the weight percent hundred of each component is in the nutrient solution, sodium selenite 0.02%, magnesium sulfate 0.2%, sodium chloride 0.2%,
Chromium chloride 0.01%, water 95.7%.
Further, after the completion of the step 1 it is by richness, to carry out being additionally provided with step P1, the step P1 before the step 2
Soya bean is placed in square position selenium, then covers by the gauze of pure water-soaked, germination 10 is carried out under 28-30 DEG C, dark surrounds small
When, obtain germination selenium-rich soya bean of the sprout length in 3-5mm.
Sodium selenite fully absorbs nutrient solution as inorganic selenium, selenium-rich soya bean after being soaked through the nutrient solution containing inorganic selenium,
Sorption enhanced effect then is carried out to inorganic selenium in germination process, makes Se accumulation in the amino acid contained by sprout, protein etc.
On molecule, so as to increase the content of vegetable active selenium in selenium-rich natto, make to contain selenoprotein and selenium propylhomoserin, profit in selenium-rich natto powder
In absorption of human body, wherein selenium has antioxidative synergistic effects with protein binding, so as to be conducive to improving the activity of Nattokinase；And
And in the crust of sprout bursting selenium-rich soya bean, increase the gap between selenium-rich soya bean, for the fermentation of bafillus natto provides sky
Between, and bafillus natto can be entered into selenium-rich soya bean by the gap between sprout and crust, be on the one hand easy to make
Bafillus natto during the fermentation, produces the inorganic selenium that will be remained in inside and outside selenium-rich soya bean while Nattokinase to change into
Organic Selenium, so as to greatly reduce the residual of inorganic selenium；On the other hand the tunica albuginea for being formed selenium-rich natto surface is more uniform, abundant
Be distributed in inside and outside selenium-rich natto, make that Nattokinase is distributed in natto is more uniform, and natto is increased to a certain extent
The content of kinases.
Preferably, the selenium-rich soya bean and the weight ratio of nutrient solution in the step 1 are 1:4.
It is an advantage of the invention that：
1st, the absorption, the reduction blood fat content that suppress fat in enteron aisle to a certain extent；
2nd, internal existing thrombus and patch is dissolved；
3rd, internal free radical can be to a certain extent removed, prevents lipid oxidation, repair impaired blood vessel, soften blood
Pipe increases blood vessel elasticity, prevents the formation of secondary thrombus；
4th, fat absorption, reduction blood fat content, thrombus, inhibition thrombosis, reparation blood vessel, enhancing vascular toughness etc. are suppressed
Many-sided collective effect, effectively reduces the probability of happening of cardiovascular and cerebrovascular disease；
5th, pineapple powder, apple powder and konjaku flour give off a strong fragrance, sweet flavor, micro- acid can effectively remove the ammonia stink of natto powder,
Enhancing products taste；
6th, when brewing for 40 DEG C, gelatinous mass and glucomannans contained by konjaku flour can water absorption and swelling formation glue for product of the present invention
Body parcel natto powder, pineapple powder and apple powder, can reduce the destruction to Nattokinase and other active materials such as hydrochloric acid in gastric juice, activity
Composition not easy in inactivation；
7th, while being rich in vegetable active selenium and Organic Selenium, and will be remained in inside and outside selenium-rich soya bean while Nattokinase is produced
Inorganic selenium changes into Organic Selenium, greatly reduces the residual of inorganic selenium, is easy to absorption of human body.
Brief description of the drawings
Fig. 1 is the fabrication processing figure in the present invention.
Specific embodiment
Below by embodiment, the invention will be further described.It should be understood that being prepared described in the embodiment of the present invention
Method is only used for the explanation present invention, rather than limitation of the present invention, the present invention is made under concept thereof of the invention
The simple modifications of Preparation Method belong to the scope of protection of present invention.
Involved all substances are commercially available in the embodiment of the present invention, and apple powder and grape fruit powder are purchased from Xi'an Bei Lasheng
Thing Science and Technology Ltd., konjaku flour is purchased from Henan Yong En bio tech ltd.
Embodiment 1：
The manufacturing process of selenium-rich natto fine powder is as follows：
A, production natto
1. selenium-rich soya bean pretreatment：By raw material selenium-rich soya bean by manual grading skill screen, removal selenium-rich soya bean in mix stone,
The impurity such as wood chip, through hand picking full seed, size unification, bright selenium-rich soya bean (selenium-rich soya bean select Hubei grace
Apply the selenium-rich soya bean of plantation, Se content：0.12mg/Kg)；
2. impregnate：The selenium-rich soya bean that will be pre-processed is cleaned rear by weight 1:4 ratio impregnates in adding nutrient solution, 7 DEG C of dippings
20 hours, rinsed with pure water afterwards, wherein nutrient solution includes following component as expressed in weight percent：Sodium selenite
0.02%th, magnesium sulfate 0.2%, sodium chloride 0.2%, chromium chloride 0.01%, pure water 95.7%；
3. germinate：The selenium-rich soya bean that will have been impregnated is placed in square position, is then covered by the gauze of pure water-soaked, 28-30 DEG C,
Germination 10 hours is carried out under dark surrounds, germination selenium-rich soya bean of the sprout length in 3-5mm is obtained；
4. boiling：The selenium-rich soya bean for having germinateed is placed in high steam pot, 121 DEG C of boilings 25 minutes；
5. it is inoculated with：Selenium-rich soya bean after boiling is cooled to 40 DEG C or so, 3% inoculum concentration, inoculation are pressed by the way of spraying
Bafillus natto；
6. ferment：Fermented in the selenium-rich soya bean propulsion fermenting cellar that will be inoculated with, fermentation temperature is 37 DEG C, and relative humidity is maintained at
Between 85%-100%, fermentation can obtain fresh natto in 24 hours；
7. maturation：The natto that will be fermented is placed in 0 DEG C and places 12 hours, and selenium-rich natto is obtained.
B, preparation selenium-rich natto fine powder
1. by step A produce selenium-rich natto it is freeze-dried remove moisture removal, first with pulverizer preliminary crushing to 60 mesh, then use
Ultramicro grinding homogenizer is crushed, and crosses 180 mesh vibratory sieves and selenium-rich natto powder is obtained；
2. selenium-rich natto powder 350g, pineapple powder 280g, apple powder 140g, konjaku flour 130g are placed in Multidimensionblender and mixed
20-30 minutes, temperature control, then through 38 DEG C of dehumidifiers, was dried at 38 DEG C, is made selenium-rich natto fine powder.
Embodiment 2-7 and time, the time of boiling, temperature, the inoculum concentration of fermentation that the difference of embodiment 1 is dipping
Difference, and the proportioning of selenium-rich natto powder, pineapple powder, apple powder, grape fruit powder, konjaku flour is different, as shown in table 1 below：
Table 1
Embodiment 8：It is to save sprouting step with the difference of embodiment 1.
The selenium-rich natto sensory properties of the production of embodiment 1 to 8：
The selenium-rich natto of the technique productions of embodiment 8, selenium-rich natto surface after fermentation forms one layer of tunica albuginea, tacky, wire drawing compared with
It is long, there is metallic luster, sprout is into ecru.The selenium-rich natto viscosity of the wherein production technology production of embodiment 1 is most strong, and wire drawing is most
It is long, and because Nattokinase is primarily present in the sticky wire drawing of natto, therefore can be tentatively from the sensory properties of natto
Go out, there is Nattokinase content higher in the natto of the production of embodiment 1；The selenium-rich natto of embodiment 1-7 productions, after fermentation
One layer of tunica albuginea distribution that selenium-rich natto surface is formed is more uniform, gained selenium-rich natto yellowish.
In the selenium-rich natto produced to embodiment 8 with bacterium colony colony counting method and FU determined by ultraviolet spectrophotometry embodiment 1
Se content in the content of bafillus natto and Nattokinase, and detection selenium-rich natto, testing result is as shown in table 2：
Table 2
| Nattokinase (FU) | Selenium (mg/kg) | ||
| Embodiment 1 | 1372 | 52 | 6.79 |
| Embodiment 2 | 1224 | 49 | 6.11 |
| Embodiment 3 | 1129 | 48 | 6.23 |
| Embodiment 4 | 1244 | 39 | 6.32 |
| Embodiment 5 | 1101 | 38 | 6.02 |
| Embodiment 6 | 1037 | 43 | 5.87 |
| Embodiment 7 | 1028 | 41 | 5.98 |
| Embodiment 8 | 1305 | 51 | 3.52 |
Authorization Notice No. is the patent of CN101411437B, and it is 20-27min to use dip time, after boiling 20-25min, 30-
55 DEG C of nattos of the production technology production of fermentation 10-16h, natto specification is Nattokinase content >=230FU, bafillus natto
Number >=3*109cfu/g。
1000FU/g is above by the Nattokinase content produced in embodiment 1-7 as can be seen from Table 2, with existing skill
Art increases significantly compared to tool, and the content of bafillus natto and Nattokinase is higher wherein in embodiment 1, natto gemma
Bacillus content increases the Nattokinase for being conducive to its secretion more to cross, and the Nattokinase of high level is conducive to dissolving composition blood vessel
Important substance-the insoluble fibrin of wall patch, and then increase dissolving patch and thrombus effect.
Experimental example A:Selenium-rich natto fine powder sensory properties
It is random to select 16-30 Sui, 30-55 Sui, the richness that the 50-80 Sui subject of three age brackets prepares to each embodiment in the present invention
Selenium natto fine powder and commercially available pure selenium-rich natto powder product, fresh natto product carry out sensory aspect (color and luster, smell, mouthfeel) evaluation
Marking, appraisal result is as shown in table 3 below, and wherein each age bracket selects 30 subjects, takes 90 subjects altogether and scores number
Average value be final result.In test, color and luster：10 points of colors liked the most for subject；Smell：10 points are liked for subject
Joyous highest scoring；Taste：10 points are scored for the highest that subject likes.
Table 3
| Color and luster (10 points) | Smell (10 points) | Mouthfeel (10 points) | |
| Embodiment 1 | 9.6 | 9.5 | 9.6 |
| Embodiment 2 | 9.4 | 9.3 | 9.4 |
| Embodiment 3 | 9.4 | 9.3 | 8.9 |
| Embodiment 4 | 9.5 | 9.3 | 9.1 |
| Embodiment 5 | 9.2 | 9.2 | 9.1 |
| Embodiment 6 | 9.3 | 9.4 | 9.3 |
| Embodiment 7 | 9.3 | 9.1 | 9.2 |
| Pure selenium-rich natto powder | 8.3 | 6.2 | 5.1 |
| Fresh natto | 8.6 | 4.0 | 3.2 |
Result shows, selenium-rich natto fine powder prepared by embodiment 1-7 be substantially better than on smell and mouthfeel pure selenium-rich natto powder and
Fresh natto, obtains the consistent accreditation of subject.
Experimental example B：Effect to thrombus in rat body
Thrombus experiment, anti-oxidant experiment in rat body, natto application effect experiment, with the micro- blood of the prevention for illustrating the present composition
Bolt and oxidation resistant effect.
1st, experiment material
1.1 experimental drugs：
1.2 experimental animals：Rat is purchased from Beijing Co., Ltd of dimension tonneau China, male.
1.3 laboratory apparatus：ACL coagulo meters；
1.4 experiment reagents：TT (thrombin time of blood plasma measure kit), PT (serum PT in patients kit),
APTT (active partial thromboplastin time measure kit), FIB (fibrinogen assay kit) reagent must purchased from Nanjing
Shi get biotechnologies company.
2nd, experimental technique
By the rat of 90 health, every 10 one group is randomly divided into 9 groups, and each group uses gavage approach daily in addition to normal feeding
It is administered once, gavage 30 days.
Negative control group：Daily group gives physiological saline gavage once, daily according to 10ml/kg body weight gavages, without modeling
Treatment；
Model control group：Daily group gives physiological saline gavage once, daily according to 10ml/kg body weight gavages, the 3rd day gavage reciprocal
After start modeling treatment.
From embodiment 1 prepare selenium-rich natto fine powder as tested material, the human body recommended dose of the tested material is
0.05g/d*kg body weight.10 times of the dose,equivalent of rat equivalent to human body recommended dose.Respectively with the 5 of human body recommended dose
Times, 10 times and 30 times as basic, normal, high dosage, separately constitute selenium-rich natto fine powder low dose group (abbreviation low dose group), selenium-rich
Natto fine powder middle dose group (abbreviation middle dose group), selenium-rich natto fine powder high dose group (abbreviation high dose group).Will be basic, normal, high
The tested material of dosage, is brewed with pure water, daily according to 10ml/kg body weight gavages.Start at modeling after 3rd day gavage reciprocal
Reason.
Composition A groups：Apple powder is lacked compared with selenium-rich natto fine powder group, test dose is identical with middle dose group, it is reciprocal
Start modeling treatment after 3rd day gavage.
Composition B groups：Pineapple powder is lacked compared with selenium-rich natto fine powder group, test dose is identical with middle dose group, it is reciprocal
Start modeling treatment after 3rd day gavage.
Composition C groups：Selenium-rich natto powder is lacked compared with selenium-rich natto fine powder group, test dose is identical with middle dose group,
Start modeling treatment after 3rd day gavage reciprocal.
Composition D groups：Konjaku flour is lacked compared with selenium-rich natto fine powder group, test dose is identical with middle dose group, it is reciprocal
Start modeling treatment after 3rd day gavage.
Start modeling after gavage within the 3rd day in inverse, precision weighs carrageenan, and 3.5% (g/ml) is made into physiological saline
Concentration；To rat weight, in addition to negative control group, in metapedes toe hypodermic injection carrageenan, dosage is 30mg/kg to each group
Body weight.Rat is placed in (18 ± 2) DEG C indoor feeding, black tail length after measurement rat modeling 24h, 48h, 72h after modeling.Most
Afterwards after one-shot measurement black tail length, each group rat anesthesia, inferior caval vein takes whole blood, is sub-packed in two test tubes, takes whole blood, determines solidifying
Hemase time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FIB).
3rd, statistical method, continuous data average value ± standard error represents that comparison in difference is checked using t between each group, by
Excel software statistics are completed.For there were significant differences, p ＜ 0.01 are have pole significant difference to P ＜ 0.05.
4th, result and analysis, influence of the selenium-rich natto fine powder to rat tail and such as table 4 below of the influence to blood coagulation system
With shown in table 5.
Effect of the different product of table 4 to rat black tail length (cm)
Note：Compared with negative control group, * * P ＜ 0.01, * * * P ＜ 0.001；Compare #P ＜ 0.05, ##P ＜ with model group
0.01, ###P ＜ 0.001.
As shown in Table 4：Compared with negative control group, model group 48h black tails length extremely significantly increases (P ＜ 0.001)；
At 24 hours, composition A groups substantially suppressed the growth (P ＜ 0.05) of black tail compared with model group, and low dose group is notable
Suppression black tail growth (P ＜ 0.01), middle dose group and high dose group pole significantly inhibit the growth (P ＜ 0.001) of black tail；With
Composition A groups, composition B groups, composition C groups, the effect of composition D groups are compared, and basic, normal, high dosage group is respectively provided with preferably
Effect, and the effect of composition A groups, composition B groups, composition C groups, composition D groups is significantly lower than low dose group.
At 48 hours, low dose group, can significantly suppress the growth (P ＜ 0.01) of black tail, middle dose group, high dose group
Extremely can significantly suppress the growth (P ＜ 0.001) of black tail；With composition A groups, composition B groups, composition C groups, composition D groups
Effect compare, the effect of excellent three groups of the effect of basic, normal, high dosage group, and composition A groups, composition B groups, composition C
Group, the effect of composition D groups are significantly lower than low dose group.
At 72 hours, composition A groups substantially suppressed the growth (P ＜ 0.05) of black tail, and low dose group significantly suppresses black
The growth (P ＜ 0.01) of tail, middle dose group and high dose group pole significantly inhibit the growth (P ＜ 0.001) of black tail；With composition A
Group, composition B groups, composition C groups, the effect of composition D groups are compared, and basic, normal, high dosage group is respectively provided with preferably effect, and
Composition A groups, composition B groups, composition C groups, the effect of composition D groups are significantly lower than low dose group.
Influence of the table 5 to blood coagulation system
Note：Compared with negative control group, * * P ＜ 0.01, * * * P ＜ 0.001；Compare #P ＜ 0.05, ##P ＜ with model group
0.01, ###P ＜ 0.001.
As shown in Table 5, compared with negative control group, the thrombin time of model group significantly shortens (P ＜ 0.01), fiber egg
White former increase, but without significant difference；Compared with model group, composition A groups, composition B groups, composition C groups, composition D groups
Prothrombin time (P ＜ 0.05) can significantly be increased, low dose group, middle dose group can significantly increase prothrombin time (P
＜ 0.01), high dose group extremely can significantly increase thrombin time (P ＜ 0.001)；With composition A groups, composition B groups, combine
Thing C groups, the effect of composition D groups are compared, and the effect of basic, normal, high dosage group is substantially better than the effect.
Binding analysis table 4 and table 5：
Composition A groups lack apple powder, and contain substantial amounts of flavonoids and pectin in apple powder, can promote by Nattokinase institute
The thrombus of dissolving metabolic adsorption in vivo.The free radical produced after blood inner lipid is oxidized in metabolic process is by selenium-rich natto
Organic Selenium in powder is removed, so as to suppress the biosynthesis of internal cholesterol simultaneously in vivo in the thrombus discharge for accelerating to be dissolved,
The effect for suppressing recurrence of thrombus is further functioned as while enhancing thrombolysis Scavenging activity.And the freedom produced after being oxidized
Base reduces its damage to vascular endothelial cell after being eliminated, so as to aid in increasing brass reparation because thrombus is dissolved by Nattokinase
Afterwards exposed impaired blood vessel efficiency, softening blood vessel increases blood vessel elasticity, and reducing blood fat, to pile up shape at impaired place rows of
The probability of thrombus.
Lack pineapple powder in composition B groups, and contain substantial amounts of biological glucoside and pineapple proteinase in pineapple powder, obstruction can be dissolved
Fibrin and blood clot in tissue, can combine Nattokinase thrombus and blood clot makes thrombus disappear, but also
Local blood circulation can be improved, diminished inflammation, so as to accelerate blood flow, accelerate to dissolve transport and the generation of the thrombus for diminishing
Thank.The natural materials of free radical are also removed in pineapple containing substantial amounts of vitamin C, organic acid, niacin etc., can aid in repairing blood
Pipe epithelial cell.Although the apple powder, konjaku flour and selenium-rich natto powder in composition B groups coordinate increases selenium-rich to a certain extent
The ability of Nattokinase thrombus in natto powder, but thrombus material reduce, can equally reduce overall thrombus
Effect.Thus explanation pineapple powder joint other components accelerate the dissolving of thrombus, and by improving blood circulation, lift blood stream
Speed, drives the thrombus in ablation, accelerates the metabolism of thrombus after dissolving, so as to greatly improve thrombolytic effect, and to a certain degree
On play suppress recurrence of thrombus effect.
Lack selenium-rich natto powder in composition C groups, and Nattokinase is the main matter of thrombus in natto, so that molten
Thrombolysis efficiency is reduced on bolt source, and only provided reduction blood fat content by tomato meal, fruit powder and konjaku flour, suppressed low density lipoprotein
The effects such as the impaired blood vessel of protein oxidation, reparation, its drop thrombus effect can be substantially reduced.Additionally, the selenium in selenium-rich natto powder is
Food source antioxidant, can remove the excessive oxygen radical of human body, can prevent the free radical that lipid is produced after being oxidized to blood vessel
The damage of endothelial cell, lacking Organic Selenium can cause whole composition, and the function of repairing improvement blood vessel is had a greatly reduced quality, so as to weaken
The function of pre- preventing thrombosis.
Lack konjaku flour in composition D groups, gelatinous mass and glucomannans contained by konjaku flour can water absorption and swelling formation glue
Body parcel selenium-rich natto powder, pineapple powder and apple powder, can reduce hydrochloric acid in gastric juice etc. to Nattokinase, other protease and remove freely
The destruction of the active material of base, it is ensured that active component non-inactivation.Additionally, glucomannans and gelatinous mass in konjaku can be with
Synergy, suppresses the absorption of fat in alimentary canal.Lack protective effect of the konjaku flour to other Composition Active materials, can cause
Active ingredient partial inactivation in other components, reduces thrombus, repairs the work(of blood vessel, reduction blood fat and inhibition thrombosis
Effect.
Equally, the formula to embodiments of the invention 2-7 is tested, and effect is same as Example 1, can suppress black tail
Length, increase factor time, with synergy.
Experimental example C：
The selenium-rich natto fine powder prepared in embodiment 1 is chosen, according to daily warm boiled water 1-2g, C1, C2, C3, C4, C5 five
Subject is taken four months, and the arteria carotis of the patient is detected using colorful Doppler ultrasound diagnostic apparatus, predominantly detects subject's
Plaque within blood vessels, endangium thickness and blood flow state.Take front and rear physical examination result as shown in table 6 below.
Table 6
The physical examination result of each patient shows that the blood vessel thickness of the patient is obviously reduced after taking four months, vessel wall thickness
Recover normal.Blood drag index declines, frequency spectrum compared with four months before when not taking, more regular, overall blood flow is obviously improved.This
Outward, the original cardiovascular and cerebrovascular abnormality of patient is considerably reduced, especially numbness in hands and feet, asthma uncomfortable in chest, brain activity deficiency etc.
Cardiovascular and cerebrovascular abnormality disappears substantially.
Claims (6)
1. a kind of selenium-rich natto fine powder, it is characterised in that including following components represented with weight portion：
30-42 parts of selenium-rich natto powder,
Pineapple powder 25-32 parts,
Apple powder 10-16 parts,
Konjaku flour 11-15 parts.
2. selenium-rich natto fine powder according to claim 1, it is characterised in that including following components represented with weight portion：
35 parts of selenium-rich natto powder,
28 parts of pineapple powder,
14 parts of apple powder,
13 parts of konjaku flour.
3. a kind of method of the selenium-rich natto fine powder made described in claim 1-2 any one, it is characterised in that including following
Step：Step 1：Selenium-rich soya bean is impregnated in water, 5-8 DEG C impregnates 12-28 hours；
Step 2：By selenium-rich soya bean be placed in high steam pot in, 121 DEG C boiling 22-30 minutes；
Step 3：Selenium-rich soya bean after boiling is cooled to 40 DEG C, the inoculum concentration of 1%-5% is pressed by the way of spraying, inoculation is received
Beans bacillus；
Step 4：Fermented in the selenium-rich soya bean propulsion fermenting cellar that will be inoculated with, fermentation temperature is 35-39 DEG C, and relative humidity is maintained at
85%-100%, fermentation can obtain fresh natto in 24 hours；
Step 5：The fresh natto that will be fermented is placed in 0 DEG C and places 12 hours, and selenium-rich natto is obtained；
Step 6：In step 5 produce natto it is freeze-dried removes moisture removal, first with pulverizer preliminary crushing to 60 mesh, then with surpass
Micro-disintegrating homogenizer is crushed, and crosses 180 mesh vibratory sieves and selenium-rich natto powder is obtained；
Step 7：Selenium-rich natto powder, pineapple powder, apple powder, konjaku flour are placed in Multidimensionblender and are mixed 20-30 minutes, temperature
Control, then through 38 DEG C of dehumidifiers, is dried at 38 DEG C, is made selenium-rich natto fine powder.
4. the preparation method of selenium-rich natto fine powder according to claim 3, it is characterised in that：To the water in the step 1
Middle addition sodium selenite, magnesium sulfate, sodium chloride and chromium chloride are made nutrient solution, the weight percent hundred of each component in the nutrient solution
For sodium selenite 0.02%, magnesium sulfate 0.2%, sodium chloride 0.2%, chromium chloride 0.01%, water 95.7%.
5. the preparation method of selenium-rich natto fine powder according to claim 4, it is characterised in that：After the completion of the step 1, enter
It is that selenium-rich soya bean is placed in square position to be additionally provided with step P1, the step P1 before the row step 2, is then covered by pure water logging
Wet gauze, carries out germination 10 hours under 28-30 DEG C, dark surrounds, and the germination selenium-rich for obtaining sprout length in 3-5mm is yellow
Beans.
6. the preparation method of selenium-rich natto fine powder according to claim 5, it is characterised in that：Selenium-rich in the step 1
Soya bean is 1 with the weight ratio of nutrient solution:4.
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