CN103230478A - Selenium-rich natto product - Google Patents
Selenium-rich natto product Download PDFInfo
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- CN103230478A CN103230478A CN2013101586843A CN201310158684A CN103230478A CN 103230478 A CN103230478 A CN 103230478A CN 2013101586843 A CN2013101586843 A CN 2013101586843A CN 201310158684 A CN201310158684 A CN 201310158684A CN 103230478 A CN103230478 A CN 103230478A
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- 229910052711 selenium Inorganic materials 0.000 title claims abstract description 204
- 239000011669 selenium Substances 0.000 title claims abstract description 204
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title claims abstract description 193
- 235000013557 nattō Nutrition 0.000 title claims abstract description 140
- 239000000843 powder Substances 0.000 claims abstract description 103
- 229940094952 green tea extract Drugs 0.000 claims abstract description 26
- 235000020688 green tea extract Nutrition 0.000 claims abstract description 26
- 229940086319 nattokinase Drugs 0.000 claims abstract description 18
- 108010073682 nattokinase Proteins 0.000 claims abstract description 18
- 230000002526 effect on cardiovascular system Effects 0.000 claims abstract description 15
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims abstract description 10
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a selenium-rich natto product, which comprises the following components in parts by weight: 35-50 parts of selenium-rich natto powder, 10-16 parts of phytosterol powder and 10-15 parts of green tea extract powder. The selenium-rich natto powder contains selenium natto kinase with high activity and long lasting time, and organic selenium, thus having an excellent antioxidation effect; phytosterol contained in the phytosterol powder has the effects of inhibiting cholesterol absorption of a human body, promoting katabolism of cholesterol, inhibiting biochemical synthesis of the cholesterol and the like; and catechinic acid contained in the green tea extract powder has the effects of inhibiting blood pressure and blood sugar, reducing cholesterol and low density lipoprotein in blood and increasing the content of high density lipoprotein. According to the selenium-rich natto product, the selenium-rich natto powder, the phytosterol powder and the green tea extract powder are combined in scientific proportion to take effect together in three aspects of inhibiting thrombus formation, improving thrombus dissolution and enhancing the toughness of blood vessels, and therefore, the selenium-rich natto product is capable of effectively preventing cardiovascular and cerebrovascular diseases.
Description
Technical field
The present invention disclose a kind of for thrombus, prevent thrombotic natto product, especially a kind of rich selenium natto product that is rich in selenium nattokinase and organic selenium.
Background technology
At present, China's cardiovascular and cerebrovascular vessel thrombotic disease is one of the most serious and modal disease of harm middle-aged and elderly people health.According to statistics, there are about 1,500 ten thousand people of thrombotic disease patient in the whole world, wherein dies from about 1,200 ten thousand people of cardiovascular and cerebrovascular vessel thrombotic disease every year.In China, the relapse rate in 1 year is that the relapse rate in 30%, the five year is up to 59% behind the apoplexy patient discharge.Because China is populous, the pace of population aging accelerates, so effectively preventing cardiovascular and cerebrovascular vessel thrombotic disease is significant.Though present existing treatment thrombosis medicine is obtained significant effect, has some limitation, such as anticoagulant and antiplatelet drug certain side effect is arranged, and can't thrombus main matter insoluble fibrin.The thrombolytic drug oral administration is invalid, can only be used for injection, and injected dose is excessive may to cause massive hemorrhage in the body, and it is very careful to need.In addition, its half-life in human body is very short, so onset time is very short.And some Chinese medicines, such as Semen Ginkgo, Radix Salviae Miltiorrhizae, Radix Notoginseng, Hirudo etc., can't thrombus main matter insoluble fibrin, mainly be to play the effect of regulating blood fat.
Nattokinase is proved to be effectively thrombus, mainly is effectively to dissolve insoluble fibrin, and this albumen is the important substance of forming the blood vessel wall speckle.But the activity of the nattokinase of traditional natto product is lower, is 1000FU/g, and the persistent period is short, and the thrombolytic effect is limited.At present, the selenium in the product of the natto product of rich selenium or other thrombus dissolvings generally all is selenocarrageenan, perhaps inorganic selenium; the absorption rate of selenium is limited; and selenium is blood vessel antioxidative active substance, can strengthen vascular toughness, and the protection blood vessel is not subjected to radical damage.Cholesterol, low density lipoprotein, LDL all are the materials that strengthens blood viscosity, causes lipid metabolic disorder, and lipid material forms little " speckle " gradually in blood vessel wall inner membrance deposition, medically becomes " atherosclerosis ".These specklees increase, increase, and artery-clogging causes the blood vessel official jargon narrow gradually, and blood circulation is not smooth, if vitals tremulous pulse blood supply insufficiency will cause serious consequence.Usually serious is the cardiovascular and cerebrovascular vessel atherosclerosiss, can cause coronary heart disease, myocardial infarction, angina pectoris, cerebral thrombosis, cerebral hemorrhage, apoplexy etc., even threat to life.Existing product is not taken into account three aspects such as thrombus, antioxidation vessel softening, reduction thrombosis desired substance simultaneously, and thrombolytic natto kinase activity is low, and action time is not lasting, and the effect of therefore preventing and treating cardiovascular and cerebrovascular disease is restricted.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art part and provide a kind of can from suppress thrombosis, increase thrombosis dissolving, strengthen vascular toughness three aspect combineds effect, the rich selenium natto product that effectively prevent cardiovascular and cerebrovascular disease to take place; In addition, the present invention also provide described rich selenium natto product for the preparation of the prevention or the treatment cardiovascular and cerebrovascular disease medicine in purposes.
For achieving the above object, the technical scheme that the present invention takes is: a kind of rich selenium natto product comprises the component of following weight portion: 35～50 parts of rich selenium natto powders, 10～16 parts in plant sterol powder, 10～15 parts in green tea extract powder.
Contain the selenium nattokinase in the rich selenium natto powder described above, it is the conjugate of selenium and nattokinase, its enzymatic activity can reach 2000～2500FU/g, compare with the nattokinase that the existing activity of using always is 1000FU/g, have the advantage of active height, longer duration, can more effective thrombus.In addition, contain selenium protein and selenium propylhomoserin in the described rich selenium natto powder, bioavailability is good, and safety.Albumen selenium is a kind of material of biologically active, selenium and protein binding have the antioxidation synergism, antioxidation is fabulous, use with the Selem solution, also have the effect of effect each other of mutually promoting, mainly show antioxidation, strengthen the toughness of blood vessel wall, remove the residue of blood vessel simultaneously.Plant sterol has stronger antiinflammatory action to human body, has can suppress human body to effects such as the absorption of cholesterol, the katabolism of promotion cholesterol, the biochemistry of inhibition cholesterol synthesize.Catechin has inhibition blood pressure (can reduce diastolic pressure and systolic pressure) and blood glucose (suppressing the candy amylase), reduces blood cholesterol and low density lipoprotein, LDL, and increases the amount of high density lipoprotein.Rich selenium natto product of the present invention, the ratio of materials such as rich selenium natto powder, plant sterol powder, green tea extract powder according to science combined, from the formation that suppresses thrombosis, the dissolving that increases thrombosis, the three aspect combineds effect of enhancing vascular toughness, effectively prevent the generation of cardiovascular and cerebrovascular disease.
As the preferred implementation of rich selenium natto product of the present invention, described rich selenium natto product comprises the component of following weight portion: 35～45 parts of rich selenium natto powders, 12～15 parts in plant sterol powder, 11～15 parts in green tea extract powder.As the more preferably embodiment of rich selenium natto product of the present invention, described rich selenium natto product comprises the component of following weight portion: 36～38 parts of rich selenium natto powders, 13～14 parts in plant sterol powder, 12～13 parts in green tea extract powder.
As the preferred implementation of rich selenium natto product of the present invention, described rich selenium natto product also comprises the adjuvant of 32～35 weight portions.As the more preferably embodiment of rich selenium natto product of the present invention, described adjuvant comprises at least a in soybean lecithin, hydroxyl isomaltulose, starch, mannitol, lactose, the magnesium stearate.
As the preferred implementation of rich selenium natto product of the present invention, described rich selenium natto powder adopts following method to be prepared from:
(1) actication of culture: activation medium contains yeast extract, peptone, dipotassium hydrogen phosphate, sodium chloride, agar and distilled water, the pH of activation medium is 7.0～7.5, with culture medium at 119～121 ℃ down behind the sterilization 30min, the inoculation Bafillus natt, and be under 36～38 ℃ Bafillus natt to be activated 24h in temperature;
(2) strain expanded culture: the culture medium that strain enlarges contains peptone, glucose, dipotassium hydrogen phosphate, magnesium sulfate, calcium chloride and distilled water, the pH of culture medium is 7.0～7.5, at 119～121 ℃ of 30min that sterilize down, the Bafillus natt after will activating then is 36～38 ℃ of following amplification culture 24h in temperature with culture medium;
(3) fermentation: Drinking Water is heated to 50～60 ℃, add the Semen Glycines rich in selenium egg albumen powder according to 10～15% of the water yield, fully stir and form Semen Glycines rich in selenium egg albumen powder suspension, in Semen Glycines rich in selenium egg albumen powder suspension, add dipotassium hydrogen phosphate then, regulating pH is 7.0～7.5, cool off behind the sterilization 30min down at 119～121 ℃, the Bafillus natt after adding step (2) amplification culture is at 36～38 ℃ of bottom fermentation 48h;
(4) fermentation liquid after step (3) fermentation is suppressed Bafillus natt at 80～85 ℃ of deactivation 35min(), after 60～70 ℃ of following vacuum dryings to solid content was 30%, lyophilization namely got rich selenium natto powder then.
As the preferred implementation of rich selenium natto product of the present invention, contain organic selenium 50～87.5 μ g/g, selenium nattokinase 2000～2500FU/g in the described rich selenium natto powder; Contain plant sterol 100～125mg/g in the described plant sterol powder; Contain catechin 100～125mg/g in the described green tea extract powder.As the more preferably embodiment of rich selenium natto product of the present invention, described organic selenium is selenium protein, selenoamino acid, selenium polysaccharide.Organic selenium mainly exists with the form of natural selenium protein, selenoamino acid in the rich selenium natto product of the present invention, as selenomethionine, seleno methyl cysteine, a small amount of is natural selenium polysaccharide, generally exist with the form of selenocarrageenan or inorganic selenium with selenium in the existing product and to compare, have that bioavailability is good, an advantage such as safety and antioxidation are good.
As the preferred implementation of rich selenium natto product of the present invention, described rich selenium natto product is tablet, capsule or powder.Rich selenium natto product of the present invention can cooperate adjuvant to be made into tablet, capsule or powder solid beverage etc., can select suitable dosage form to take according to the hobby of different crowds or different people.
In addition, the present invention also provide rich selenium natto product described above for the preparation of the prevention or the treatment cardiovascular and cerebrovascular disease medicine in purposes.
Rich selenium natto product of the present invention, described rich selenium natto powder contains selenium nattokinase and organic selenium, and the activity of selenium nattokinase is up to 2000～2500FU/g, active height and longer duration, thrombolytic is effective; Organic selenium has antioxidation, improves blood vessel wall toughness.Described plant sterol has the effect that reduces blood cholesterol levels, reduces the formation of thrombosis, and the heart disease of prevention and treatment coronary atherosclerosis class is had effect preferably.Described green tea extract has the effect that suppresses low density lipoprotein, LDL content in the blood.Rich selenium natto product of the present invention, the ratio of materials such as rich selenium natto powder, plant sterol powder, green tea extract powder according to science combined, from the formation that suppresses thrombosis, the dissolving that increases thrombosis, the three aspect combineds effect of enhancing vascular toughness, effectively prevent the generation of cardiovascular and cerebrovascular disease.
Description of drawings
Fig. 1 takes blood vessel plaque detection figure as a result before the rich selenium natto product of the present invention for Zhang.
Fig. 2 takes blood vessel plaque detection figure as a result behind the rich selenium natto product of the present invention for Zhang.
Fig. 3 takes blood vessel thickness testing result figure before the rich selenium natto product of the present invention for Zhang.
Fig. 4 takes blood vessel thickness testing result figure behind the rich selenium natto product of the present invention for Zhang.
Fig. 5 takes blood vessel plaque detection figure as a result before the rich selenium natto product of the present invention for Chen.
Fig. 6 takes blood vessel plaque detection figure as a result behind the rich selenium natto product of the present invention for Chen.
Fig. 7 takes the preceding blood vessel plaque detection of the rich selenium natto product of the present invention figure as a result for Guo.
Fig. 8 takes blood vessel plaque detection figure as a result behind the rich selenium natto product of the present invention for Guo.
Fig. 9 takes the preceding blood vessel thickness testing result figure of the rich selenium natto product of the present invention for Guo.
Figure 10 is the blood vessel thickness testing result figure after Guo takes the rich selenium natto product of the present invention.
Figure 11 takes the preceding blood vessel plaque detection of the rich selenium natto product of the present invention figure as a result for Lee.
Figure 12 takes blood vessel plaque detection figure as a result behind the rich selenium natto product of the present invention for Lee.
The specific embodiment
For the purpose, technical solutions and advantages of the present invention better are described, the invention will be further described below in conjunction with specific embodiment.
Embodiment 1
The rich selenium natto product of an embodiment of the present invention, described rich selenium natto product comprises the component of following weight portion: 35 parts of rich selenium natto powders, 16 parts in plant sterol powder, 15 parts in green tea extract powder.The described rich selenium natto product of present embodiment can be made into chewable tablet, capsule, 400mg/ sheet, edible 2～3 of every day; Perhaps be made into the powder solid beverage, use eliminating cold for resuscitation water Instant Drinks 1～2g every day.
In the described rich selenium natto product of present embodiment, the activity that contains the selenium nattokinase in the described rich selenium natto powder is 2000FU/g, organic selenium 60 μ g/g, contain plant sterol 110mg/g in the described plant sterol powder, contain catechin 100mg/g in the described green tea extract powder.The organic selenium that contains in the described rich selenium natto powder mainly exists with the form of natural selenium protein, selenoamino acid, as selenomethionine, seleno methyl cysteine, is natural selenium polysaccharide on a small quantity.
Embodiment 2
The rich selenium natto product of an embodiment of the present invention, described rich selenium natto product comprises the component of following weight portion: 50 parts of rich selenium natto powders, 10 parts in plant sterol powder, 10 parts in green tea extract powder, 5 parts of soybean lecithins, 7 parts of hydroxyl isomaltuloses, 10 parts of starch, 2 parts of mannitols, 6 parts of lactose, 5 parts of magnesium stearate.The described rich selenium natto product of present embodiment can be made into chewable tablet, capsule, 400mg/ sheet, edible 2～3 of every day; Perhaps be made into the powder solid beverage, use eliminating cold for resuscitation water Instant Drinks 1～2g every day.
In the described rich selenium natto product of present embodiment, the activity that contains the selenium nattokinase in the described rich selenium natto powder is 2200FU/g, organic selenium 50 μ g/g, contain plant sterol 100mg/g in the described plant sterol powder, contain catechin 125mg/g in the described green tea extract powder.The organic selenium that contains in the described rich selenium natto powder mainly exists with the form of natural selenium protein, selenoamino acid, as selenomethionine, seleno methyl cysteine, is natural selenium polysaccharide on a small quantity.
Embodiment 3
The rich selenium natto product of an embodiment of the present invention, described rich selenium natto product comprises the component of following weight portion: 35 parts of rich selenium natto powders, 12 parts in plant sterol powder, 15 parts in green tea extract powder, 9 parts of soybean lecithins, 4 parts of hydroxyl isomaltuloses, 15 parts of starch, 1 part of mannitol, 5 parts of lactose.The described rich selenium natto product of present embodiment can be made into chewable tablet, capsule, 400mg/ sheet, edible 2～3 of every day; Perhaps be made into the powder solid beverage, use eliminating cold for resuscitation water Instant Drinks 1～2g every day.
In the described rich selenium natto product of present embodiment, the activity that contains the selenium nattokinase in the described rich selenium natto powder is 2300FU/g, organic selenium 70 μ g/g, contain plant sterol 125mg/g in the described plant sterol powder, contain catechin 120mg/g in the described green tea extract powder.The organic selenium that contains in the described rich selenium natto powder mainly exists with the form of natural selenium protein, selenoamino acid, as selenomethionine, seleno methyl cysteine, is natural selenium polysaccharide on a small quantity.
Embodiment 4
The rich selenium natto product of an embodiment of the present invention, described rich selenium natto product comprises the component of following weight portion: 36 parts of rich selenium natto powders, 13 parts in plant sterol powder, 13 parts in green tea extract powder, 12 parts of soybean lecithins, 2 parts of hydroxyl isomaltuloses, 9 parts of mannitols, 10 parts of magnesium stearate.The described rich selenium natto product of present embodiment can be made into chewable tablet, capsule, 400mg/ sheet, edible 2～3 of every day; Perhaps be made into the powder solid beverage, use eliminating cold for resuscitation water Instant Drinks 1～2g every day.
In the described rich selenium natto product of present embodiment, the activity that contains the selenium nattokinase in the described rich selenium natto powder is 2500FU/g, organic selenium 87.5 μ g/g, contain plant sterol 120mg/g in the described plant sterol powder, contain catechin 105mg/g in the described green tea extract powder.The organic selenium that contains in the described rich selenium natto powder mainly exists with the form of natural selenium protein, selenoamino acid, as selenomethionine, seleno methyl cysteine, is natural selenium polysaccharide on a small quantity.
Embodiment 5
The rich selenium natto product of an embodiment of the present invention, described rich selenium natto product comprises the component of following weight portion: 38 parts of rich selenium natto powders, 14 parts in plant sterol powder, 12 parts in green tea extract powder, 32 parts of starch.The described rich selenium natto product of present embodiment can be made into chewable tablet, capsule, 400mg/ sheet, edible 2～3 of every day; Perhaps be made into the powder solid beverage, use eliminating cold for resuscitation water Instant Drinks 1～2g every day.
In the described rich selenium natto product of present embodiment, the activity that contains the selenium nattokinase in the described rich selenium natto powder is 2200FU/g, organic selenium 50 μ g/g, contain plant sterol 100mg/g in the described plant sterol powder, contain catechin 125mg/g in the described green tea extract powder.The organic selenium that contains in the described rich selenium natto powder mainly exists with the form of natural selenium protein, selenoamino acid, as selenomethionine, seleno methyl cysteine, is natural selenium polysaccharide on a small quantity.
Embodiment 6
The rich selenium natto product of an embodiment of the present invention, described rich selenium natto product comprises the component of following weight portion: 45 parts of rich selenium natto powders, 15 parts in plant sterol powder, 11 parts in green tea extract powder, 15 parts of soybean lecithins, 20 parts of lactose.The described rich selenium natto product of present embodiment can be made into chewable tablet, capsule, 400mg/ sheet, edible 2～3 of every day; Perhaps be made into the powder solid beverage, use eliminating cold for resuscitation water Instant Drinks 1～2g every day.
In the described rich selenium natto product of present embodiment, the activity that contains the selenium nattokinase in the described rich selenium natto powder is 2400FU/g, organic selenium 75 μ g/g, contain plant sterol 105mg/g in the described plant sterol powder, contain catechin 120mg/g in the described green tea extract powder.The organic selenium that contains in the described rich selenium natto powder mainly exists with the form of natural selenium protein, selenoamino acid, as selenomethionine, seleno methyl cysteine, is natural selenium polysaccharide on a small quantity.
Embodiment 7
Zhang, man, 63 years old, take the rich selenium natto product of the present invention according to the described method of embodiment 1-6 and dosage, took three months, the employing colorful Doppler ultrasound diagnostic apparatus detects this patient's carotid artery, mainly detects patient's the interior speckle of blood vessel, tunica intima thickness and blood flow state.This patient is before taking rich selenium natto product of the present invention, and this patient vessel's inwall speckle is obvious, the speckle size be 0.77cm * 0.20cm(as shown in Figure 1); Take the rich selenium natto product of the present invention after three months, this patient vessel's inwall speckle obviously reduces, and speckle is reduced to 0.30cm * 0.13cm(as shown in Figure 2).This patient is before taking the rich selenium natto product of the present invention, its blood vessel thickness thicker (as shown in Figure 3), take the rich selenium natto product of the present invention after three months, this patient's blood vessel thickness obviously reduces, blood vessel wall caliper recovery normal (as shown in Figure 4).Before this patient took rich selenium natto product of the present invention, the situation of cutout and eddy current appearred in its blood flow state, and took the rich selenium natto product of the present invention after three months, and it is normal that blood flow rate is recovered.This patient took rich selenium natto product of the present invention after three months, and original cardiovascular and cerebrovascular vessel abnormality greatly alleviates, and the patient feels that health is good, and especially cardiovascular and cerebrovascular vessel abnormalities such as numbness of hands and feet, asthma uncomfortable in chest, brain vigor deficiency disappear.
Embodiment 8
Chen, 87 years old, the man took the rich selenium natto product of the present invention according to the described method of embodiment 1-6 and dosage, takes four months, adopts colorful Doppler ultrasound diagnostic apparatus to detect before and after taking, and finds that the intracarotid speckle of this patient obviously dwindles.Big or small 2.86cm * the 0.22cm(of being of blood vessel speckle as shown in Figure 5 before this patient took the rich selenium natto product of the present invention), and take the rich selenium natto product of the present invention after four months, its blood vessel speckle size be 1.55cm * 0.17cm(as shown in Figure 6).In addition, this patient is after taking the rich selenium natto product of the present invention, and its blood drag index descends, and frequency spectrum is not when taking before four months, and more regular, whole blood flow obviously improves.
Embodiment 9
Guo, 82 years old, the man took the rich selenium natto product of the present invention according to the described method of embodiment 1-6 and dosage, takes four months, and its blood drag index descends, and frequency spectrum is not when taking before four months, and more regular, obvious eddy current reduces, and the blood engorgement degree improves.Before this patient takes the rich selenium natto product of the present invention, blood vessel speckle size be 0.58cm * 0.26cm(as shown in Figure 7), take the rich selenium natto product of the present invention after four months, blood vessel speckle size be 0.21cm * 0.18cm(as shown in Figure 8), the thrombosis speckle obviously dwindles.This patient is before taking the rich selenium natto product of the present invention, its blood vessel thickness thicker (as shown in Figure 9), take the rich selenium natto product of the present invention after four months, this patient's blood vessel thickness obviously reduces, blood vessel wall caliper recovery normal (as shown in Figure 10).
Lee, 76 years old, the woman, take the rich selenium natto product of the present invention according to the described method of embodiment 1-6 and dosage, took four months, detect with colorful Doppler ultrasound diagnostic apparatus respectively before and after taking, the local blood fullness degree obviously improved after the rich selenium natto product of the present invention was taken in discovery, and the cutout situation disappears.Before this patient takes the rich selenium natto product of the present invention, blood vessel speckle size be 1.31cm * 0.23cm(as shown in Figure 11), take the rich selenium natto product of the present invention after four months, blood vessel speckle size be 0.29m * 0.17cm(as shown in Figure 12), the thrombosis speckle significantly dwindles.
Embodiment 11
Lee, 56 years old, the man took the rich selenium natto product of the present invention according to the described method of embodiment 1-6 and dosage, takes four months, and physical examination result is as follows before and after taking:
| The health check-up project | Before taking (mmol/l) | Take back (mmol/l) |
| T-CHOL | 6.3 | 4.3 |
| HDL-C | 1.7 | 1.12 |
| Low-density lipoprotein cholesterol | 2.03 | 3.4 |
In addition, this patient took the rich selenium natto product of the present invention after four months, and uncomfortable in chest, the phenomenon of breathing hard that just occurs behind the light exercise is greatly improved before.
Can be found out that by embodiment 7-11 the rich selenium natto product of the present invention can effectively prevent the generation of cardiovascular and cerebrovascular disease from dissolving, the three aspect combineds effect of enhancing vascular toughness that suppress thrombosis, increase thrombosis.
Last institute should be noted that; above embodiment is only in order to illustrate technical scheme of the present invention but not limiting the scope of the invention; although with reference to preferred embodiment the present invention has been done detailed description; those of ordinary skill in the art is to be understood that; can make amendment or be equal to replacement technical scheme of the present invention, and not break away from essence and the scope of technical solution of the present invention.
Claims (10)
1. a rich selenium natto product is characterized in that, comprises the component of following weight portion: 35～50 parts of rich selenium natto powders, 10～16 parts in plant sterol powder, 10～15 parts in green tea extract powder.
2. rich selenium natto product as claimed in claim 1 is characterized in that, comprises the component of following weight portion: 35～45 parts of rich selenium natto powders, 12～15 parts in plant sterol powder, 11～15 parts in green tea extract powder.
3. rich selenium natto product as claimed in claim 2 is characterized in that, comprises the component of following weight portion: 36～38 parts of rich selenium natto powders, 13～14 parts in plant sterol powder, 12～13 parts in green tea extract powder.
4. rich selenium natto product as claimed in claim 1 is characterized in that, described rich selenium natto product also comprises the adjuvant of 32～35 weight portions.
5. rich selenium natto product as claimed in claim 4 is characterized in that, described adjuvant comprises at least a in soybean lecithin, hydroxyl isomaltulose, starch, mannitol, lactose, the magnesium stearate.
6. rich selenium natto product as claimed in claim 1 is characterized in that, described rich selenium natto powder adopts following method to be prepared from:
(1) actication of culture: activation medium contains yeast extract, peptone, dipotassium hydrogen phosphate, sodium chloride, agar and distilled water, the pH of activation medium is 7.0～7.5, with culture medium at 119～121 ℃ down behind the sterilization 30min, the inoculation Bafillus natt, and be under 36～38 ℃ Bafillus natt to be activated 24h in temperature;
(2) strain expanded culture: the culture medium that strain enlarges contains peptone, glucose, dipotassium hydrogen phosphate, magnesium sulfate, calcium chloride and distilled water, the pH of culture medium is 7.0～7.5, at 119～121 ℃ of 30min that sterilize down, the Bafillus natt after will activating then is 36～38 ℃ of following amplification culture 24h in temperature with culture medium;
(3) fermentation: Drinking Water is heated to 50～60 ℃, add the Semen Glycines rich in selenium egg albumen powder according to 10～15% of the water yield, fully stir and form Semen Glycines rich in selenium egg albumen powder suspension, in Semen Glycines rich in selenium egg albumen powder suspension, add dipotassium hydrogen phosphate then, regulating pH is 7.0～7.5, cool off behind the sterilization 30min down at 119～121 ℃, the Bafillus natt after adding step (2) amplification culture is at 36～38 ℃ of bottom fermentation 48h;
(4) with the fermentation liquid after step (3) fermentation at 80～85 ℃ of deactivation 35min, after 60～70 ℃ of following vacuum dryings to solid content was 30%, lyophilization namely got rich selenium natto powder then.
7. rich selenium natto product as claimed in claim 1 is characterized in that, contains organic selenium 50～87.5 μ g/g, selenium nattokinase 2000～2500FU/g in the described rich selenium natto powder; Contain plant sterol 100～125mg/g in the described plant sterol powder; Contain catechin 100～125mg/g in the described green tea extract powder.
8. rich selenium natto product as claimed in claim 7 is characterized in that, described organic selenium is selenium protein, selenoamino acid, selenium polysaccharide.
9. rich selenium natto product as claimed in claim 1 is characterized in that, described rich selenium natto product is tablet, capsule or powder.
One kind according to claim 1 rich selenium natto product for the preparation of the prevention or the treatment cardiovascular and cerebrovascular disease medicine in purposes.
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