CN106729675A - It is a kind of to treat pharmaceutical composition of cardiovascular and cerebrovascular disease and preparation method thereof - Google Patents

Abstract

A kind of pharmaceutical composition for treating cardiovascular and cerebrovascular disease, in terms of parts by weight, is made up of following composition：100 170 parts of GINKGO BILOBA EXTRACT, 40 100 parts of Fructus Jujubae extract, 100 200 parts of Mongolian snakegourd shell extract, 30 60 parts of Radix Codonopsis saponin, 50 100 parts of American ginseng saponin, 40 70 parts of astragalus saponin, 20 50 parts of hirudin, 3 10 parts of Co-Q10,40 100 parts of Semen euryales extract, 20 50 parts of converted starch, 100 150 parts of carthamin, 100 150 parts of Semen Persicae extract, 30 50 parts of Gastrodin, 120 200 parts of root of red-rooted salvia phenolic acid, 40 90 parts of Rhizoma Chuanxiong extract, 100 150 parts of notoginseng total saponin, 0 50 parts of Semen sesami nigrum element, 0 50 parts of astaxanthin；Can be used to treat hypertension, high fat of blood, insomnia, coronary heart disease and cerebral apoplexy sequela etc., have no toxic side effect.

Description

It is a kind of to treat pharmaceutical composition of cardiovascular and cerebrovascular disease and preparation method thereof

Technical field

The invention belongs to field of Chinese herbal medicine technology, and in particular to a kind of pharmaceutical composition for treating cardiovascular and cerebrovascular disease and its Preparation method.

Background technology

According to 2013 Chinese cardiovascular and cerebrovascular diseases report displays, China's cardiovascular and cerebrovascular diseases（Coronary heart disease, headstroke, heart failure, Hypertension）Number of patients 2.9 hundred million, the wherein people of hypertension 2.66 hundred million, headstroke at least 7,000,000 people, the people of myocardial infarction 2,500,000, the heart The people of force failure 4,500,000, the people of cor pulmonale 5,000,000, the people of rheumatic heart disease 2,500,000, the people of congenital heart disease 2,000,000, often It is cardiovascular and cerebrovascular diseases to have 2 people in 10 adults, daily dead 9590 people of cardiovascular and cerebrovascular diseases, accounts for the 51% of the total Death causes of China, Occupy first of various diseases, the death rate incidence of disease accounts for the whole world first.

Chinese cardiovascular and cerebrovascular diseases report shows that headstroke number of the infected is 4-5 times of myocardial infarction, and male is higher than women, In the city dweller of more than 55 years old, senile dementia illness rate is 4.7%, over-65s then 7.8%.

Hypertension is the Major Risk Factors of headstroke and incidence of coronary heart disease, in 10 years, will be had in normal value blood pressure people 50% turns into hyperpietic.More than 18 years old adult hypertension illness rate of China is 18.8%, some areas more than 25%, northern portion Region-by-region is up to more than 30%.

Substantially, illness rate is in and continues ascent stage cardio-cerebal blood vessel diseases dangerous factor trend, and burden is increasingly aggravated, it has also become Great public health problem, is also that the masses drive into poverty by medical crises the major reason returned to poverty, if effectively control not in time, serious by bringing Socioeconomic problem, therefore, it is very urgent that thorough solution cardiovascular and cerebrovascular diseases prevent and treat problem.

Generally, it is considered that in blood vessel, in heart, in brain, or even whole body, nutrient all is supplied by " blood ", transport generation Thank to rubbish, once blood is dirty, glue, before not forming plate, will be three high（High blood pressure, blood fat are high, the viscous height of blood）Once, shape Into plate, get lodged on heart, be coronary heart disease, get lodged on brain, be headstroke, it is well understood that being summarized with three words:Gas loses and causes Vascular problem, blood vessel causes blood flow problem, and blood causes cardiovascular and cerebrovascular disease, and in a word, cardiovascular and cerebrovascular diseases are unrelated with heart and brain, And have relation with following factors：

A, gas lose and cause blood vessel internal membrane damage

（1）Gas is the life sheet of people, and congenital gas, gas exists in people, and the people that draws last breath dies.Qi as the commander of blood, blood being the mother of qi, and gas pushes away blood OK.When human body unsaturated vapor, slow blood flow, flow velocity can slowly cause pressure to increase, the lipid material in blood can precipitate, attached On vascular wall, formation blood vessel is thicker, and luminal stenosis add a large amount of arteriosclerosis plaques and lipid deposition, may Angiemphraxis, supply of blood flow is caused to interrupt, endovascular toxicant is difficult discharge.If blood viscosity is too high, resistance increases Plus, if at this moment vasopasm, hypertension can be suddenly produced, if the lipid material in blood is deposited in angiocarpy, make Into coronary heart disease, the cerebrovascular is deposited in, then causes cerebrovascular disease.

（2）When causing inner membrance to sustain damage, there is denaturation, necrosis and come off in endothelial cell, subendothelial collagenous fibres are exposed, So as to activate the clotting factor of intrinsic coagulation system, intrinsic coagulation system is activated.

（3）Causing the inner membrance of damage can discharge tissue factor, activate extrinsic coagulation system.

（4）Cause the inner membrance being damaged roughening, blood platelet is easy to aggregation, mainly attach to exposed collagenous fibres On.

B, Blood vessel pattern blood flow

Human body in metabolic processes, in blood itself synthesis " cystine " and " homocysteine " two kinds of harmful substances, Both binding substances power are very strong, are also difficult to clean off than cholesterol, and it has the hardness fragility for promoting blood vessel to increase, and vascular wall increases Thickness, blood vessel becomes tiny effect.

Triglycerides, the free radical produced in human body can usually damage the DNA and gene of cell, and it is also the courage in blood Sterol is changed into and sticked in the obturator of cardiac blood tube wall, makes narrowed blood vessels, stops normal blood flow.At this moment angiotensinⅠ Also can start to be rapidly converted to angiotensinⅡ, blood pressure is caused heart change and heart attack while rising.

Someone is saying nutrition everyday, does not know that overnutrition harm more not enough than nutrition intake is much bigger but, present blood high Pressure, high fat of blood, obesity, diabetes start to targeted by the young man of 20-30 Sui, and life stress and mode allow them inordinately to consume Original life energy, vivotoxin reaches the stage that life is difficult neutralizing, the immune system infinitely overdraw of body and loses The power of activation, vascular wall is surrounded by cytotoxin, except denaturation, in addition into cholesterol, " slave " of triglycerides, he Have no option.Vascular wall starts to thicken, and starts fibrosis, starts to follow the string.High fat of blood invade it is excessive under, vascular space is opened Beginning diminishes, and human organ's blood supply one minute and one second can not stop, and heart and brain pressure is continuously increased, impulsive force of the blood to vascular wall Continue to increase.

Further, since the defect of human body itself, caused indigestion and hyposecretion, make fibrin, arm albumen and Hemoglobin forms blood clot in intravascular, endovascular bacterial cell wall because necrosis and lipidosis are on Wall of Artery, Vessel wall thickening, blood vessel elasticity is deteriorated, cause VPV slow, blood flow produces whirlpool or blood flow to be obstructed.

C, blood quality change causes cardiovascular and cerebrovascular disease

The body of people by urinary system, olfactory system, enteron aisle digestive system, central nervous system, immune system, respiratory system, The big tissue of the big system of hematopoiesis etc. eight, six big major organs livers, the heart, spleen, kidney, brain, lung, and human organ four, i.e. epithelial tissue, Form and connect tissue, musculature, nerve fiber composition.Whether eight big systems or six big organs, four big tissues, human body be all by The life of a cellularity about more than 60,000,000,000,000, and each organ of more than 60,000,000,000,000 cell distribution Whole Body and position, they Supply blood is all be unable to do without, any one system and part of human body, any one cell are required for blood to maintain them just Often operating and work.

In actual life, it is more and more smart, thin that people eat, and what nutrition was particular about is high protein, higher fatty acid, high heat.One day Breakfast, lunch and dinner chicken, duck, fish flesh and blood, tobacco and wine are continuous, the green vegetables that we eat, it may be said that be that 100% agricultural chemicals is exceeded.The chicken and duck meat that we eat The result that is all to expedite the emergence of out with hormone feed ..., the thing that cell will be eaten for us, drink, inhale is processed.The quilt eaten The vital organs of the human body are absorbed, metabolizable toxin and residue out, many when Human Lipid Metabolism obstacle occurs for various reasons Remaining cholesterol and triglycerides, fat, protein, residue will be in Remained mass.

In fact, ectotoxic ability is also limited in body treatment.If people's constipation（Stool）, the residue of food exists Fermented in colon and produce substantial amounts of toxin, can also gone to small intestine and be absorbed together with nutrient.Interior ectotoxic increase, directly receives Evil person is exactly the vital functions and cell of people, and the neutralizing ability of body fluid contratoxin has reached the limit inside and outside human body.If in human body Toxin it is too many, toxin will attack cells blood vessel, into blood.

The blood of people, if water pollution, is full of various toxin, the fishes and shrimps gone around in pond just as the water in pond in water Can also healthily liveOnce these " rubbish " toxin are piled up to form small plate in intravascular, blood vessel access diminishes, blood Coagulability increases, and blood platelet and clotting factor will increase, and according to fluidics principle, passage is small, and flow velocity is just slow, and flow tube just becomes Slightly, pressure just increases, if plate forms accumulation in vivo, may result in blocking.

Heart and brain disease treatment method, but frequent simply high blood pressure hypotensive, blood fat reducing blood lipid high, blood vessel has been blocked up and propped up Frame, support is not all right just to put up a bridge, and effect is very undesirable, and side effect even can life-threatening.Patient often loses labor to some extent Kinetic force, can a lot weigh residual or can't take care of oneself.

The content of the invention

An object of the present invention is the defect for overcoming prior art, there is provided a kind of medicine for treating cardiovascular and cerebrovascular disease Composition.

The second object of the present invention is the preparation method for providing the treatment cardiovascular and cerebrovascular diseases medicament composition.

The pharmaceutical composition of present invention treatment cardiovascular and cerebrovascular disease, in terms of parts by weight, including following composition：

GINKGO BILOBA EXTRACT 100-170 parts,	Fructus Jujubae extract 40-100 parts,	100-200 parts of Mongolian snakegourd shell extract,
			30-60 parts of Radix Codonopsis saponin,	American ginseng saponin 50-100 parts,	Astragalus saponin 40-70 parts,
Hirudin 20-50 parts,	Co-Q10 3-10 parts,	Semen euryales extract 40-100 parts,
			Converted starch 20-50 parts,	Carthamin 100-150 parts,	Semen Persicae extract 100-150 parts,
Gastrodin 30-50 parts,	Root of red-rooted salvia phenolic acid 120-200 parts,	Rhizoma Chuanxiong extract 40-90 parts,
			Notoginseng total saponin 100-150 parts,	0-50 parts of Semen sesami nigrum element,	Astaxanthin 0-50 parts.

Wherein described GINKGO BILOBA EXTRACT purity is not less than 98%, preferably 150-170 parts, the described preferred 50- of Fructus Jujubae extract consumption 80 parts, described Mongolian snakegourd shell extract is preferred 130-160 parts；

Wherein described Radix Codonopsis saponin purity is not less than 80%, and preferably 40-50 parts, described American ginseng saponin purity is more than 80% , preferably 60-70 parts, described astragalus saponin purity is not less than 80%, preferably 50-60 parts；

Wherein described hirudin purity is not less than 98%, and preferably 25-50 parts, the preferred liposoluble Co-Q10 of described Co-Q10 is pure Degree is not less than 80%, and preferably 4-8 parts, described Semen euryales extract is preferred 50-80 parts；

Wherein described converted starch is preferred 30-40 parts, and described carthamin purity is not less than 80%, preferably 130-150 parts, institute The Semen Persicae extract stated is preferred 100-120 parts；

Wherein described Gastrodin purity is not less than 98%, preferably 35-50 parts, and described root of red-rooted salvia phenolic acid purity is not less than 98%, excellent 140-150 parts is selected, described Rhizoma Chuanxiong extract is preferred 50-70 parts；

Wherein described notoginseng total saponin purity is not less than 98%, preferably 120-140 parts；

Wherein described Semen sesami nigrum element purity is not less than 98%, preferably 30-50 parts；

Wherein described astaxanthin purity is not less than 10%, preferably 30-50 parts.

The preparation method of the pharmaceutical composition for the treatment of cardiovascular and cerebrovascular disease of the present invention, comprises the following steps：

（1）The pharmaceutical composition of the treatment cardiovascular and cerebrovascular disease is gone out into the weight that processes raw material by recipe calculation, appearance ware is positioned over, It is well mixed；

（2）Powder compressing tablet, polishing that will be well mixed, then carry out after sterilization treatment obtaining finished product.

Wherein step（2）In sterilization treatment temperature be 90-110 DEG C, preferably 90-100 DEG C.

The medicine dominant mechanism of present invention treatment cardiovascular and cerebrovascular diseases medicament composition is described as follows：

GINKGO BILOBA EXTRACT, Fructus Jujubae extract, Radix Codonopsis saponin, American ginseng saponin, astragalus saponin, hirudin, Semen euryales extract, peach kernel are carried Take the natural traditional Chinese medicines such as thing, Gastrodin, root of red-rooted salvia phenolic acid, notoginseng total saponin, Semen sesami nigrum element contain natural flavone, isoflavones, soaps with And phospholipid and various enzymes, possess have foster the spirit of nobility, efficient fast decoupled dissolves lipid and thrombus and other blood dirt deposit Function.

Experiment is proved, after clothes for patients is used, contained phospholipid and flavones, isoflavones, soaps and small molecule complex enzyme, rapidly AP is penetrated into, and broken wall decomposition is carried out to the oil cells in blood, progressively removed, reach neutralizing patch, expanded Blood vessel, softening blood vessel, the tension force and elasticity that recover blood vessel, repair blood vessel and reduce vascular resistence, and blood flow speed is accelerated, and pressure becomes It is small, the heart it is not flurried not bitterly, breathing it is normal, make one glowing with health, the full god's foot of gas, human body lipoprotein can averagely rise 33% or so, glycerine Three esters can averagely decline 28% or so, and thrombolysis removes more than 98%, and the amount of blood supply of cardiovascular and cerebrovascular can reach normally, blood high Pressure, hyperlipemia disappear substantially.Its mechanism of action mainly has：

（1）, after thrombolytic drug of fostering the spirit of nobility combined with fibrin ferment, the proteolysis of fibrin ferment is acted on and is nursed one's health with endothelial cell thrombus The combination of element is restricted；

（2）, thrombin induction platelet aggregation and release function be prevented from；

（3）, the effect such as stimulated by thrombin fibroblast proliferation and smooth muscle cell contraction it is suppressed；

（4）, thrombin action be suppressed in the contractile function of damaged blood vessels, so as to play good anticoagulant effect.

Mechanism is specifically divided into following five step:

The first step：Foster the spirit of nobility haemolysis.Radix Codonopsis saponin, American ginseng saponin, astragalus saponin, Semen euryales extract, hirudin, ground bettle are extracted The nourishing Yin and keeping spirit function of the taste Chinese medical extract of thing, Scorpio extract etc. 7, gas allows the blood to have power enough, before this " haemolysis " Carry；

Second step：Soothing the liver net blood.The taste Chinese medical extract of carthamin, Semen Persicae extract, Mongolian snakegourd shell extract, root of red-rooted salvia phenolic acid etc. 4, dredges The net blood of liver, cuts grease, cholesterol, blood is not had " pollution source ", and this is the basic of " thrombolysis of fostering the spirit of nobility "；

3rd step：Filling liver kidney hemofiltration.The tonifying kidney and benefiting sperm for playing the 3 taste Chinese medical extracts such as Gastrodin, Semen sesami nigrum element, astaxanthin is made With, the rubbish in blood quickly to be removed, this is the guarantee of " thrombolysis of fostering the spirit of nobility "；

4th step：Cardiac stimulant pump blood.GINKGO BILOBA EXTRACT, Co-Q10（Liposoluble）, notoginseng total saponin, the 4 taste traditional Chinese medicine extractions such as Rhizoma Chuanxiong extract Thing, can softening blood vessel, recover elasticity of heart, conserve heart and brain, this is the basis of " thrombolysis of fostering the spirit of nobility ".

5th step：Invigorating the spleen green blood.The invigorating the spleen temperature stomach effect of Fructus Jujubae extract, Millettia extract is played, promotes qi and blood life Change, this is the source of " thrombolysis of fostering the spirit of nobility ".

The Main Ingredients and Appearance hirudin fostered the spirit of nobility in thrombolytic drug, in vivo without degraded, with active component through RE.Leech Plain body is easily accepted by, and immunity is weak, and blood platelet, fibrinogen level and content of hemoglobin are not influenceed, not easily passs through blood brain CSF barrier, sufficiently stable, simple temperature is raised（100 DEG C of water-baths）Change with pH value does not influence its activity, therefore fosters the spirit of nobility The effect of Thrombolytic Therapy in Treatment heart and brain thrombus is generally acknowledged.

Present invention treatment cardiovascular and cerebrovascular diseases medicament composition, the advanced overcritical biology that raw materials used composition is used is carried Technology preparation is taken, without chemistry and biochemical reaction, whole preparation process of extracting is pure physical behavio(u)r to its production process, so, this hair Bright drug composition product is free of any chemical adding ingredient, after measured without any toxicity, liver, kidney and other organs is not produced Any secondary influence of poison.

Cardiovascular and cerebrovascular diseases medicament composition of the present invention can Hypertension, hyperlipemia, heart disease, rheumatic heart Disease, left atrium thicken hypertrophy, heart severe ischemic, angina pectoris, coronary sclerosis, coronary atherosclerosis, heart is vexed gas Short, miocardial infarction, cerebral infarction, various thromboembolism thrombus, cerebrovascular sequelae, apoplexy sequelae, hemiplegia, can prevent to suppress sugar Urine disease, senile dementia, tumour, cancer etc..

Cardiovascular and cerebrovascular diseases medicament composition tablet specification of the present invention：It is deep rice-pudding color or brown tablet, every net weight 680mg。

The application method of present invention treatment cardiovascular and cerebrovascular diseases medicament composition tablet is as follows：

（1）Hypertrophy, heart severe ischemic, angina pectoris are thickened for high blood pressure, hyperlipemia, heart disease, left atrium, it is coronal Artery sclerosis, coronary atherosclerosis, heart is vexed shortness of breath, miocardial infarction, cerebral infarction, various thromboembolism thrombus patients, take this hair Bright cardiovascular and cerebrovascular diseases medicament composition tablet, 3 times a day, and 2 tablets once, every 680mg, and warm water is taken after mixing it with water within 40 minutes before meals, and 30 It is 1 course for the treatment of.

（2）Hemiplegia, cerebrovascular sequelae, apoplexy sequelae, senile dementia patient, except taking heart and brain blood of the present invention Pipe disease medicament composition tablet（3 times a day, and 2 tablets once, every 680mg）Outward, the piece that plays both sides of the street as described below is preferably added Agent (3 times a day, and 2 tablets once or 3, every 550mg), two kinds of medicines are taken simultaneously（3 tablets once for preceding 10 days tablets that play both sides of the street, 2 tablets once later）, warm water is taken after mixing it with water within 40 minutes before meals, is within 30 days 1 course for the treatment of.

The clothes play both sides of the street tablet in terms of parts by weight, including following composition：

Eleutheroside 120-200 parts,	Fructus Lipuidambaris extract 150-230 parts,
		Eupolyphaga seu steleophaga extract 120-160 parts,	Scorpio extract 100-150 parts,
Millettia extract 130-180 parts,	200-250 parts of Entada phaseoloides extract,
		Radix Fissistigmatis Oldhamii extract 50-150 parts,	Converted starch 20-50 parts.

Cardiovascular and cerebrovascular diseases medicament composition tablet of the present invention is used for hypertension, high fat of blood and insomniac, generally has as follows Effect：

After taking 7 days, a not dizzy, head is not had a sleepless night bitterly,, and daytime is not sleepy, and sleep soundly in the evening；

After taking 15 days, index declines more than half, not dreaminess, not nightmare, and getting up early is not felt bad, work ethos；

Take 30 days, eyelet is not black, the colour of skin is ruddy, no longer palpitation and short breath, no longer dizziness and tinnitus, rate and blood-lipid decreased tends to normal value； Index declines more than half, not dreaminess, not nightmare, and getting up early is not felt bad, work ethos；

Take 2 courses for the treatment of（30 days as one therapeutic course）, blood pressure tends to be steady, and life recovers completely, and strength foot, spirit are prosperous.Serious disease People generally require the 6-8 course for the treatment of can thoroughly rehabilitation, take leave of hypertension, high fat of blood and bring pain, no longer worry hemiplegia, people Seemingly juvenescence.

The criticality of hypertension is already adapted to due to hypertensive patient, with too fast too urgent medicine is depressured, has easily been gone out Now palpitate quickly, dizzy uncomfortable sensation such as powerless.The medicine of hypotensive is typically all diuretics, though temporarily reduce blood Pressure, but long-term use can cause blood viscosity higher, and blood dirt deposition, blood vessel embolism make the blood vessel of original high resilience, more Plus aging fragility, finally result in serious consequence.And it in hyperpietic is often involuntary latent that thrombolytic drug of fostering the spirit of nobility is Blood pressure just recovers normally, normal value progressively to be arrived after typically taking 2 months in the meaning, reaches preferable effect.

Cardiovascular and cerebrovascular diseases medicament composition tablet of the present invention is used for cardiac, generally has the effect that：

After taking 15 days, the heart is not flurried, chest is not vexed, gas is not short, the past with palpitaition, atrial fibrillation, cardiac arrhythmia, premature beat, dizziness etc. Disease disappears；

After taking 30 days, coronary heart diseases and angina pectoris, heart rate exhaustion, myocardial ischemia fundamental turn for the better, cardiac index are normal；

After taking 2 courses for the treatment of, heartbeat is strong, and pulse is normal, and patient can feel that heart is strong strong, as at an early age, sternly Heavy patient generally requires the 6-8 course for the treatment of can thoroughly rehabilitation.

Cardiovascular and cerebrovascular diseases medicament composition tablet of the present invention is used for cerebral apoplexy sequela patient, generally has following effect Really：

After taking 15 days, not dizziness, do not have a headache, patient substantially feels to take a favorable turn；

After taking 30 days, do not slobber, can speak, trick is warmed, brothers begin with consciousness；

After taking 45 days, speech understands, oneself can have a meal, leave the bed, helped by people and gone to toilet, by turning battle outdoor activity；

After taking 2 courses for the treatment of, can speak, energy oneself is had a meal, oneself is left the bed, gradually can outdoor activity；

After taking 3 courses for the treatment of, there is fundamental turn for the better in cerebral thrombus, cerebral hemorrhage, hemiplegia, recover normal condition, and serious patient one As need the 6-8 course for the treatment of can thoroughly rehabilitation.

Thrombotic diseases are a kind of high incidence, high concurrent disease rate, misdiagnosis rate high, the disease of high mortality, thus efficiently The thrombolytic drug of safety is the heat subject of current medical field research.But Western medicine anticoagulant and thrombolytic medicine is to arteriovenous blood around Bolt, atrial thrombus therapeutic effect it is not satisfactory, the thrombolytic drug of clinical practice exist decrease of platelet, cruor time extending, The side effect of internal organs bleeding etc., so that carrying out blood coagulation testing inspection at any time, side effects of pharmaceutical drugs even can prestige Side of body life.Cardiovascular and cerebrovascular diseases medicament composition of the present invention is used for thrombotic diseases, then in the absence of these problems.

Specific embodiment

Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.

The purity of GINKGO BILOBA EXTRACT used is 98% in embodiment, and Radix Codonopsis saponin purity is 80%, and American ginseng saponin purity is 80%, astragalus saponin purity is 80%, and hirudin purity is 98%, and carthamin purity is 80%, and Gastrodin purity is 98%, danshensu Sour purity is 98%, and notoginseng total saponin purity is 98%, and Semen sesami nigrum element purity is 98%, and astaxanthin purity is not 10%；

Co-Q10 purity used is 80% in embodiment, and embodiment 1-10 liposoluble Co-Q10s, embodiment 11 is formulated and embodiment 10 is identical, but Co-Q10 is water-soluble, and the tablet formulation that plays both sides of the street that the clinical test of embodiment 11 is used is same as in Example 10.

Table 1, table 2 are the Example formulations of pharmaceutical composition of the present invention（In units of mg）

Table 1

	Embodiment 1	Embodiment 2	Embodiment 3	Embodiment 4	Embodiment 5	Embodiment 6
							GINKGO BILOBA EXTRACT	150	140	160	160	170	120
Fructus Jujubae extract	80	70	50	80	60	100
							Mongolian snakegourd shell extract	130	130	150	150	160	140
Radix Codonopsis saponin	50	50	50	50	50	55
							American ginseng saponin	60	70	70	70	70	65
Astragalus saponin	50	60	50	50	50	45
							Hirudin	50	30	20	25	50	40
Co-Q10	4	4	4	4	4	7
							Semen euryales extract	70	50	70	80	80	63
Converted starch	30	30	30	30	30	40
							Carthamin	130	130	130	150	130	140
Semen Persicae extract	100	120	110	100	100	120
							Gastrodin	50	50	40	50	36	40
Root of red-rooted salvia phenolic acid	170	140	150	150	150	130
							Rhizoma Chuanxiong extract	60	50	60	55	70	45
Notoginseng total saponin	140	140	140	140	140	130
							Semen sesami nigrum element	50g	50	50	0	30	40
Astaxanthin	36	36	36	36	0	40
							Amount to	1360	1350	1370	1380	1380	1360

Table 2

	Embodiment 7	Embodiment 8	Embodiment 9	Embodiment 10	Embodiment 11
						GINKGO BILOBA EXTRACT	155	165	150	165	165
Fructus Jujubae extract	75	65	80	55	55
						Mongolian snakegourd shell extract	140	145	145	155	155
Radix Codonopsis saponin	40	45	55	45	45
						American ginseng saponin	60	65	65	65	65
Astragalus saponin	55	50	60	55	55
						Hirudin	25	20	35	45	45
Co-Q10	6	8	9	4	4
						Semen euryales extract	64	52	61	75	75
Converted starch	35	40	35	40	40
						Carthamin	135	145	135	145	145
Semen Persicae extract	105	115	105	106	106
						Gastrodin	45	35	50	35	35
Root of red-rooted salvia phenolic acid	145	135	140	140	140
						Rhizoma Chuanxiong extract	65	55	65	60	60
Notoginseng total saponin	120	125	125	135	135
						Semen sesami nigrum element	45	50	0	35	35
Astaxanthin	45	45	45	0	0
						Amount to	1360	1360	1360	1360	1360

The preparation method of above example is as follows：

The first step:By above-mentioned GINKGO BILOBA EXTRACT, Fructus Jujubae extract, Mongolian snakegourd shell extract, Radix Codonopsis saponin, American ginseng saponin, Radix Astragali soap Glucoside, hirudin, Co-Q10（Liposoluble）, Semen euryales extract, converted starch, carthamin, Semen Persicae extract, Gastrodin, danshensu The raw materials such as acid, Rhizoma Chuanxiong extract, notoginseng total saponin, Semen sesami nigrum element, astaxanthin dry powder calculate raw material weight by formula rate, respectively Weigh；

Second step:Alleged each raw material of acquirement is positioned in stirring appearance ware, stirring 20 minutes is mixed；

3rd step:By well mixed material compressing tablet into 680mg tablets, polishing, 100 DEG C sterilize 20 minutes.

The using effect situation of above example is as follows；

Clinical effectiveness shows, the patient in the state of an illness 1 year, sees within 7 days that effect is normal, state of an illness patient more than a year, according to Stage takes, and has preferable therapeutic effect.

Experimental technique：

A groups:Hypertensive patient 15, gives every thrombolysis tablet of fostering the spirit of nobility of patient's embodiment 1 respectively, and 3 times a day, and 2 tablets once, Every 680mg, 40 minutes warm boiled waters before meals, 30 days is 1 course for the treatment of, takes 8 courses for the treatment of.

B groups:（1）Treatment Coronary Heart Disease Patients 25, give every thrombolysis tablet of fostering the spirit of nobility of patient's embodiment 2, daily 3 respectively Secondary, 2 tablets once, every 680mg, before meals 40 minutes warm boiled waters, and 30 days is 1 course for the treatment of, takes 8 courses for the treatment of.

C groups:High fat of blood patient 60, is divided into 4 groups, every group of 15 people, take respectively embodiment 3, embodiment 4, embodiment 5, The thrombolysis tablet of fostering the spirit of nobility of embodiment 6,3 times a day, and 2 tablets once, every 680mg, before meals 40 minutes warm boiled waters, is within 30 days 1 The individual course for the treatment of, takes 8 courses for the treatment of.

D groups:Paralysis due to windstroke patient 60, is divided into 6 groups, every group of 10 people, wherein 5 groups are taken the embodiment of the present invention 7, reality respectively Apply the thrombolysis tablet of fostering the spirit of nobility of example 8, embodiment 9, embodiment 10, embodiment 11（3 times a day, and 2 tablets once, every 680mg）, and together When take the tablet that plays both sides of the street as shown in the table（3 times a day, and 3 tablets once within first 10 days, changes every time later and takes 2, every 550mg）, 40 minutes warm boiled waters before meals, 30 days is 1 course for the treatment of, takes 8 courses for the treatment of.

The other 1 group thrombolysis tablet of fostering the spirit of nobility for only taking the embodiment of the present invention 7, as a control group, 3 times a day, and 2 tablets once, Every 680mg.

The formula of the D groups tablet that plays both sides of the street used is as follows：

	Embodiment 7	Embodiment 8	Embodiment 9	Embodiment 10	Embodiment 11
						Eleutheroside	165	125	155	170	170
Fructus Lipuidambaris extract	180	220	170	185	185
						Eupolyphaga seu steleophaga extract	125	130	155	145	145
Scorpio extract	115	125	110	105	105
						Millettia extract	145	135	155	165	165
Entada phaseoloides extract	250	245	235	210	210
						Radix Fissistigmatis Oldhamii extract	80	85	95	75	75
Converted starch	40	35	25	45	45
						Amount to	1100	1100	1100	1100	1100

The preparation method of the D groups tablet that plays both sides of the street used is identical with the preparation method of medicinal composition tablets of the present invention.

E groups:Thrombolysis is contrasted, and is divided to Chinese and western drugses to treat two groups of F, G two groups of comparitive study patient in age, sex, thrombus shape Into the aspect comparing difference such as position, the course of disease, clinical manifestation without conspicuousness.

Experimental result：

A groups:Hypertension people, 15 patient's diastolic pressures more than 180mmHg, systolic pressure more than 110mmHg, main suit is dizzy, Tinnitus, uncomfortable in chest, shortness of breath, insomnia, head Doppler display blood vessel have Partial Blocking.

After using composition of the invention 7 days, after taking 7 days, a not dizzy, head is not had a sleepless night bitterly,, and daytime is not sleepy, evening On sleep soundly；

After taking 15 days, index declines most, and getting up early is not felt bad, work ethos；

Take 30 days, eyelet is not black, the colour of skin is ruddy, no longer palpitation and short breath, no longer dizziness and tinnitus, rate and blood-lipid decreased tends to normal value； Index declines more than half, not dreaminess, not nightmare, and getting up early is not felt bad, work ethos；

After taking 3 courses for the treatment of, blood pressure tends to be steady, and life recovers completely, and strength foot, spirit are prosperous.

After using 8 courses for the treatment of of composition of the invention, there are 14 patient's diastolic pressures to be reduced to below 140mmHg, systolic pressure 100mmHg or so, chief complaint disappears, and head Doppler display blood vessel is no abnormal, and electrocardiogram display cardiac and cerebral blood-supply is normal； 1 patient is invalid.

B groups:Treatment Coronary Heart Disease Patients, the symptom of 25 patients is nervous, shortness of breath, is felt suffocated, the irregular panic attacks in chest, is walked Road is breathed, weak on his pins, electrocardiogram display blood supply wretched insufficiency.

After taking 15 days, the heart is not flurried, chest is not vexed, gas is not short, the past with palpitaition, atrial fibrillation, cardiac arrhythmia, premature beat, dizzy It is dizzy to wait disease to disappear；

After taking 30 days, coronary heart diseases and angina pectoris, heart rate exhaustion, myocardial ischemia fundamental turn for the better, cardiac index are normal；

After taking 2 courses for the treatment of, heartbeat is strong, and pulse is normal.

After using 3 courses for the treatment of of tablet of the invention, 25 patients, 22 patient symptoms have improvement.16 electrocardiogram checks, 14 are shown that V5T is enhanced, and the S-T segment person of forcing down is shown before 13 medications, and 12 improve, and 1 constant；Average V5T ripples before medication Amplitude is 0.96 millimeter, and average T wave-amplitudes increase to 2.7 millimeters after medication；Average S-T segment declines 0.84 millimeter, medication before medication S-T segment averagely declines 0.27 millimeter afterwards.Most obvious 1 of change February before medication finds there is old Anterior wall myocardial infarction, Electrocardiogram V2-V4QS ripples, T ripples are inverted, and patient's symptom is obviously improved after 2 courses for the treatment of of medication, and V2-V4Q ripples disappear, in V5T wave direction； Another 1 original angina pectoris and sinus standstill, V5T popins are smooth, using 8 courses for the treatment of of tablet of the invention after, T ripples are back to normally, sinus The static disappearance of property.

C groups:After 8 courses for the treatment of of tablet of the invention, 59 patient symptoms disappear, and blood lipids index recovers normal, in addition 1 patient symptom for taking embodiment 4 mitigates, but blood lipids index is still higher.

D groups:60 patient symptoms are obnubilation, and eye angle is askew, paralysis bed.

It is as follows that this group takes effect：

Thrombolysis is contrasted:

F groups：Chinese herbs group, 15 patients take the thrombolysis tablet of fostering the spirit of nobility of embodiment 6（3 times a day, and 2 tablets once, every 680mg）30 days, through B ultrasonic detection display atrial thrombus, 14 all disappeared, 1 partial disappearance.

G groups：Western medicine group, 15 patients treat 30 days through anticoagulant and thrombolytic, are detected through B ultrasonic and shown, 9 thrombus all disappear Lose, 4 partial disappearances, 2 invalid.

Complication during thrombolysis：F groups 15 have no bleeding, have 3 slight gastrointestinal reaction occur, give and locate to the ill Disappeared after reason, F groups carry out hemagglutination test detection, and every assay is in normal range (NR).G group western medicine groups, bleeding gums, Subcutaneous ecchymosis 6,2 lower limb fester.Checked through laboratory blood urine：Western medicine group is in drip-feed liquaemin, oral warfarin, quiet Arteries and veins must regularly detect APTT, fibrinogen, antiprothrombin III, D- dimers when injecting urokinase, as a result there is substantially different Often change.Using the pharmaceutical composition thrombolysis of present invention treatment cardiovascular and cerebrovascular disease, safely and effectively without blood testing.

Claims (10)

1. a kind of pharmaceutical composition for treating cardiovascular and cerebrovascular disease, it is characterised in that in terms of parts by weight, by following composition system Into：GINKGO BILOBA EXTRACT 100-170 parts, Fructus Jujubae extract 40-100 parts, 100-200 parts of Mongolian snakegourd shell extract, Radix Codonopsis saponin 30-60 Part, American ginseng saponin 50-100 parts, astragalus saponin 40-70 parts, hirudin 20-50 parts, Co-Q10 3-10 parts, Semen euryales extract It is 40-100 parts, converted starch 20-50 parts, carthamin 100-150 parts, Semen Persicae extract 100-150 parts, Gastrodin 30-50 parts, red 120-200 parts of phenolic acid of ginseng, Rhizoma Chuanxiong extract 40-90 parts, notoginseng total saponin 100-150 parts, 0-50 parts of Semen sesami nigrum element, astaxanthin 0-50 Part.

2. it is according to claim 1 treatment cardiovascular and cerebrovascular disease pharmaceutical composition, it is characterised in that described Gingko yellow Ketone purity is not less than 98%, and consumption is 150-170 parts, and described Fructus Jujubae extract is 50-80 parts, described Mongolian snakegourd shell extract It is 130-160 parts.

3. it is according to claim 1 treatment cardiovascular and cerebrovascular disease pharmaceutical composition, it is characterised in that described Radix Codonopsis soap Glucoside purity is not less than 80%, and consumption is 40-50 parts, and described American ginseng saponin purity is more than 80%, and consumption is 60-70 parts, described Astragalus saponin purity be not less than 80%, consumption is 50-60 parts.

4. it is according to claim 1 treatment cardiovascular and cerebrovascular disease pharmaceutical composition, it is characterised in that described hirudin Purity is not less than 98%, and consumption is 25-50 parts, and described Co-Q10 purity is not less than 80%, and consumption is 4-8 parts, described Gorgon fruit Extract is 50-80 parts.

5. the pharmaceutical composition for the treatment of cardiovascular and cerebrovascular disease according to claim 1, it is characterised in that described denaturation is formed sediment Powder is 30-40 parts, and described carthamin purity is not less than 80%, and consumption is 130-150 parts, and described Semen Persicae extract is 100- 120 parts.

6. it is according to claim 1 treatment cardiovascular and cerebrovascular disease pharmaceutical composition, it is characterised in that described Gastrodin Purity is not less than 98%, and consumption is 35-50 parts, and described root of red-rooted salvia phenolic acid purity is not less than 98%, and consumption is 140-150 parts, described Rhizoma Chuanxiong extract be 50-70 parts.

7. it is according to claim 1 treatment cardiovascular and cerebrovascular disease pharmaceutical composition, it is characterised in that described pseudo-ginseng is total Glucoside purity is not less than 98%, and consumption is 120-140 parts.

8. it is according to claim 1 treatment cardiovascular and cerebrovascular disease pharmaceutical composition, it is characterised in that described Semen sesami nigrum Plain purity is not less than 98%, and consumption is 30-50 parts.

9. it is according to claim 1 treatment cardiovascular and cerebrovascular disease pharmaceutical composition, it is characterised in that described astaxanthin Purity is not less than 10%, and consumption is 30-50 parts.

10. the preparation method of the pharmaceutical composition of the treatment cardiovascular and cerebrovascular disease according to claim 1-9, including following step Suddenly：

（1）The pharmaceutical composition of the treatment cardiovascular and cerebrovascular disease is gone out into the weight that processes raw material by recipe calculation, appearance ware is positioned over, It is well mixed；

（2）Powder compressing tablet, polishing that will be well mixed, then finished product is carried out after sterilization treatment obtaining, wherein sterilization treatment condition is：Temperature 90-100 DEG C, time 20-30 minutes of degree.