WO2014207567A3 - Procédé de préparation d'abiratérone et d'intermédiaires de ce dernier - Google Patents

Procédé de préparation d'abiratérone et d'intermédiaires de ce dernier Download PDF

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Publication number
WO2014207567A3
WO2014207567A3 PCT/IB2014/002020 IB2014002020W WO2014207567A3 WO 2014207567 A3 WO2014207567 A3 WO 2014207567A3 IB 2014002020 W IB2014002020 W IB 2014002020W WO 2014207567 A3 WO2014207567 A3 WO 2014207567A3
Authority
WO
WIPO (PCT)
Prior art keywords
intermediates
abiraterone
preparation
preparing abiraterone
hydroxy
Prior art date
Application number
PCT/IB2014/002020
Other languages
English (en)
Other versions
WO2014207567A2 (fr
Inventor
Lung-Huang Kuo
Hsiao-Ping Fang
Ming-Feng Wu
Yu-Sheng Chang
Original Assignee
Scinopharm Taiwan, Ltd.
Scinopharm Singapore Pte, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scinopharm Taiwan, Ltd., Scinopharm Singapore Pte, Ltd. filed Critical Scinopharm Taiwan, Ltd.
Priority to CN201480037231.8A priority Critical patent/CN105377871B/zh
Priority to JP2016522894A priority patent/JP6474799B2/ja
Priority to AU2014300639A priority patent/AU2014300639B2/en
Priority to EP14817726.4A priority patent/EP3013848B1/fr
Priority to ES14817726T priority patent/ES2705579T3/es
Priority to CA2914305A priority patent/CA2914305A1/fr
Priority to KR1020167001565A priority patent/KR20160024930A/ko
Publication of WO2014207567A2 publication Critical patent/WO2014207567A2/fr
Publication of WO2014207567A3 publication Critical patent/WO2014207567A3/fr
Priority to IL242943A priority patent/IL242943A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La présente invention concerne des intermédiaires utilisés pour la préparation d'abiratérone et des procédés de préparation d'abiratérone et de ses intermédiaires. Les intermédiaires comprennent un composé de formule (IV), dans laquelle R représente un groupe hydroxy-protecteur.
PCT/IB2014/002020 2013-06-28 2014-06-26 Procédé de préparation d'abiratérone et d'intermédiaires de ce dernier WO2014207567A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CN201480037231.8A CN105377871B (zh) 2013-06-28 2014-06-26 阿比特龙及其中间体的制备方法
JP2016522894A JP6474799B2 (ja) 2013-06-28 2014-06-26 アビラテロン及びその中間体の調製方法
AU2014300639A AU2014300639B2 (en) 2013-06-28 2014-06-26 Process for the preparation of abiraterone and intermediates thereof
EP14817726.4A EP3013848B1 (fr) 2013-06-28 2014-06-26 Procédé de préparation d'abiratérone et d'intermédiaires de ce dernier
ES14817726T ES2705579T3 (es) 2013-06-28 2014-06-26 Procedimiento de preparación de abiraterona e intermedios de la misma
CA2914305A CA2914305A1 (fr) 2013-06-28 2014-06-26 Procede de preparation d'abiraterone et d'intermediaires de ce dernier
KR1020167001565A KR20160024930A (ko) 2013-06-28 2014-06-26 아비라테론 및 이의 중간체의 제조를 위한 방법
IL242943A IL242943A0 (en) 2013-06-28 2015-12-03 A process for the preparation of abiraterone and its intermediates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361840590P 2013-06-28 2013-06-28
US61/840,590 2013-06-28

Publications (2)

Publication Number Publication Date
WO2014207567A2 WO2014207567A2 (fr) 2014-12-31
WO2014207567A3 true WO2014207567A3 (fr) 2015-08-06

Family

ID=52116220

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/002020 WO2014207567A2 (fr) 2013-06-28 2014-06-26 Procédé de préparation d'abiratérone et d'intermédiaires de ce dernier

Country Status (11)

Country Link
US (1) US9556218B2 (fr)
EP (1) EP3013848B1 (fr)
JP (1) JP6474799B2 (fr)
KR (1) KR20160024930A (fr)
CN (1) CN105377871B (fr)
AU (1) AU2014300639B2 (fr)
CA (1) CA2914305A1 (fr)
ES (1) ES2705579T3 (fr)
IL (1) IL242943A0 (fr)
TW (1) TWI506034B (fr)
WO (1) WO2014207567A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2663469T3 (es) * 2013-07-29 2018-04-12 Industriale Chimica S.R.L. Proceso para la preparación de abiraterona y acetato de abiraterona
CN105646637B (zh) * 2014-11-28 2018-12-14 四川海思科制药有限公司 一种阿比特龙衍生物及其制备方法和医药用途
CN105503992A (zh) * 2016-01-22 2016-04-20 江苏联环药业股份有限公司 一种醋酸阿比特龙的制备方法
CN107840866A (zh) * 2016-09-20 2018-03-27 正大天晴药业集团股份有限公司 醋酸阿比特龙的制备方法
CN111303234A (zh) * 2020-02-28 2020-06-19 江西青峰药业有限公司 一种醋酸阿比特龙单晶及其制备方法
CN111410620A (zh) * 2020-03-21 2020-07-14 浙江华贝药业有限责任公司 一种化合物的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110288288A1 (en) * 2004-08-24 2011-11-24 Btg International Limited Process for the preparation of 17-0-vinyl- triflates as intermediates
CN103059091A (zh) * 2012-11-22 2013-04-24 苏州雷纳药物研发有限公司 一种避免重金属残留的醋酸阿比特龙的制备方法

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US5604213A (en) 1992-03-31 1997-02-18 British Technology Group Limited 17-substituted steroids useful in cancer treatment
GB0418900D0 (en) * 2004-08-24 2004-09-29 Btg Int Ltd Novel salt forms
WO2008110941A2 (fr) * 2007-03-14 2008-09-18 Universite De La Mediterranee Nouveau procédé de synthèse d'un précurseur de squalamine et/ou de trodusquemine
CN101768199B (zh) * 2009-12-24 2014-03-26 深圳万乐药业有限公司 醋酸阿比特龙的多晶型物及其制备方法
CN103282358A (zh) * 2010-12-16 2013-09-04 生化马林制药公司 C-17-杂芳基类固醇化合物作为cyp11b、cyp17 及/或cyp21 抑制剂
CN102030798B (zh) 2010-12-17 2012-10-17 深圳万乐药业有限公司 一种醋酸阿比特龙的纯化方法
JP6091510B2 (ja) 2011-10-10 2017-03-08 ザック システム １７−置換ステロイドの製造方法
EP2607371A1 (fr) 2011-12-23 2013-06-26 Crystal Pharma, S.A.U. Procédés de préparation d'abiratérone et composés associés
CN102898495B (zh) * 2012-11-12 2014-11-26 浙江神洲药业有限公司 醋酸阿比特龙酯的制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110288288A1 (en) * 2004-08-24 2011-11-24 Btg International Limited Process for the preparation of 17-0-vinyl- triflates as intermediates
CN103059091A (zh) * 2012-11-22 2013-04-24 苏州雷纳药物研发有限公司 一种避免重金属残留的醋酸阿比特龙的制备方法

Non-Patent Citations (3)

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Title
GRAVETT, EDWARD C. ET AL.: "A Suzuki coupling approach to bufadienolides", TETRAHEDRON LETTERS, vol. 42, no. 51, 2001, pages 9081 - 9084, XP004323323 *
SUN, QIAN ET AL.: "Pd(PPh(3))(4)/AgOAc-catalyzed coupling of 17-steroidal triflates and alkynes: Highly efficient synthesis of D-ring unsaturated 17- alkynylsteroids", STEROIDS, vol. 75, no. 12, December 2010 (2010-12-01), pages 936 - 943, XP027221112 *
YU , WENSHENG ET AL.: "A facile generation of enolates from silyl enol ethers by potassium ethoxide", TETRAHEDRON LETTERS, vol. 42, no. 3, 2001, pages 369 - 372, XP004316571 *

Also Published As

Publication number Publication date
AU2014300639B2 (en) 2018-03-01
WO2014207567A2 (fr) 2014-12-31
ES2705579T3 (es) 2019-03-26
JP6474799B2 (ja) 2019-02-27
US9556218B2 (en) 2017-01-31
CN105377871A (zh) 2016-03-02
EP3013848A4 (fr) 2017-03-15
CA2914305A1 (fr) 2014-12-31
TW201506035A (zh) 2015-02-16
CN105377871B (zh) 2017-06-06
EP3013848A2 (fr) 2016-05-04
IL242943A0 (en) 2016-02-01
EP3013848B1 (fr) 2018-10-17
US20150005489A1 (en) 2015-01-01
KR20160024930A (ko) 2016-03-07
TWI506034B (zh) 2015-11-01
JP2016523889A (ja) 2016-08-12
AU2014300639A1 (en) 2015-12-17

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