WO2014141292A3 - Polymorphe de citrate d'endoxifène et son procédé de préparation - Google Patents

Polymorphe de citrate d'endoxifène et son procédé de préparation Download PDF

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Publication number
WO2014141292A3
WO2014141292A3 PCT/IN2014/000136 IN2014000136W WO2014141292A3 WO 2014141292 A3 WO2014141292 A3 WO 2014141292A3 IN 2014000136 W IN2014000136 W IN 2014000136W WO 2014141292 A3 WO2014141292 A3 WO 2014141292A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymorph
preparing
same
endoxifen
endoxifen citrate
Prior art date
Application number
PCT/IN2014/000136
Other languages
English (en)
Other versions
WO2014141292A2 (fr
Inventor
Sanjay Jagdish Desai
Brijesh Dinkarrai DESAI
Jayesh Viththal GUNA
Sunil Chandulal PATEL
Original Assignee
Intas Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intas Pharmaceuticals Limited filed Critical Intas Pharmaceuticals Limited
Publication of WO2014141292A2 publication Critical patent/WO2014141292A2/fr
Publication of WO2014141292A3 publication Critical patent/WO2014141292A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

Cette invention concerne une nouvelle forme cristalline de citrate d'endoxifène et son procédé de préparation.
PCT/IN2014/000136 2013-03-04 2014-03-03 Polymorphe de citrate d'endoxifène et son procédé de préparation WO2014141292A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN646/MUM/2013 2013-03-04
IN646MU2013 IN2013MU00646A (fr) 2013-03-04 2014-03-03

Publications (2)

Publication Number Publication Date
WO2014141292A2 WO2014141292A2 (fr) 2014-09-18
WO2014141292A3 true WO2014141292A3 (fr) 2014-12-24

Family

ID=51538243

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2014/000136 WO2014141292A2 (fr) 2013-03-04 2014-03-03 Polymorphe de citrate d'endoxifène et son procédé de préparation

Country Status (2)

Country Link
IN (1) IN2013MU00646A (fr)
WO (1) WO2014141292A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017016376A (es) 2015-06-16 2018-03-02 Jiangsu Hengrui Medicine Co Derivado de piperidina y metodo de preparacion y uso farmaceutico del mismo.
CN107428721B (zh) 2015-12-22 2020-07-28 江苏恒瑞医药股份有限公司 苯并哌啶类衍生物、其制备方法及其在医药上的应用
AU2018329202B2 (en) 2017-09-11 2022-10-27 Atossa Therapeutics, Inc. Methods for making and using endoxifen
NZ764463A (en) 2017-11-14 2023-07-28 Kind Pharmaceutical Heterocyclic compound and application thereof in medicine
TW202140495A (zh) 2020-01-10 2021-11-01 大陸商江蘇恆瑞醫藥股份有限公司 三環四氫異喹啉類衍生物、其製備方法及其在醫藥上的應用
CA3177266A1 (fr) * 2020-04-10 2021-10-14 Jina Pharmaceuticals, Inc. Endoxifene pour le traitement d'un trouble bipolaire i
EP4132497A4 (fr) * 2020-04-10 2024-04-24 Jina Pharmaceuticals Inc Endoxifène pour le traitement d'un trouble bipolaire i
CA3225268A1 (fr) 2021-07-09 2023-01-12 Lina Jia Types de sel de derive de tetrahydroisoquinoleine tricyclique
TW202340135A (zh) 2022-01-12 2023-10-16 美商阿托薩醫療公司 （ｚ）—因多昔芬之組合物及其富集方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576645B1 (en) * 1999-11-16 2003-06-10 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
WO2009120999A2 (fr) * 2008-03-28 2009-10-01 Olema Pharmaceuticals, Inc. Utilisation d’un promédicament d’endoxifène dans le traitement du cancer de la poitrine
WO2010135703A2 (fr) * 2009-05-21 2010-11-25 Jina Pharmaceuticals, Inc. Procédés et compositions d'endoxifène pour traiter des maladies de mammifères
WO2012050263A1 (fr) * 2010-10-15 2012-04-19 Cj Cheiljedang Corp. Nouveau procédé de préparation d'endoxifen

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576645B1 (en) * 1999-11-16 2003-06-10 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
WO2009120999A2 (fr) * 2008-03-28 2009-10-01 Olema Pharmaceuticals, Inc. Utilisation d’un promédicament d’endoxifène dans le traitement du cancer de la poitrine
WO2010135703A2 (fr) * 2009-05-21 2010-11-25 Jina Pharmaceuticals, Inc. Procédés et compositions d'endoxifène pour traiter des maladies de mammifères
WO2012050263A1 (fr) * 2010-10-15 2012-04-19 Cj Cheiljedang Corp. Nouveau procédé de préparation d'endoxifen

Also Published As

Publication number Publication date
WO2014141292A2 (fr) 2014-09-18
IN2013MU00646A (fr) 2015-06-26

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