WO2014185461A1 - Composition d'agents de croissance capillaire - Google Patents

Composition d'agents de croissance capillaire Download PDF

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Publication number
WO2014185461A1
WO2014185461A1 PCT/JP2014/062869 JP2014062869W WO2014185461A1 WO 2014185461 A1 WO2014185461 A1 WO 2014185461A1 JP 2014062869 W JP2014062869 W JP 2014062869W WO 2014185461 A1 WO2014185461 A1 WO 2014185461A1
Authority
WO
WIPO (PCT)
Prior art keywords
hair
component
restorer composition
hair restorer
growth
Prior art date
Application number
PCT/JP2014/062869
Other languages
English (en)
Japanese (ja)
Inventor
俊輔 廣島
青野　恵
恭史 柿澤
利江 廣畠
Original Assignee
ライオン株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ライオン株式会社 filed Critical ライオン株式会社
Priority to CN201480025097.XA priority Critical patent/CN105163717B/zh
Priority to KR1020157025699A priority patent/KR102164151B1/ko
Priority to JP2015517114A priority patent/JP6172269B2/ja
Publication of WO2014185461A1 publication Critical patent/WO2014185461A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the present invention relates to a hair restorer composition capable of imparting a sufficient volume to hair.
  • a hair growth agent can usually obtain a hair growth effect (suppression of hair loss, promotion of hair growth) by continuous use. Therefore, it is difficult to improve the hair volume reduction (appearance of thin hair), which is a symptom of alopecia, in a short period of time, and a hair restorer with a function that gives a soft feeling in a shorter period of use than the period of use of the hair restorer Was desired.
  • Patent Documents 1 and 2 JP-A-60-243010, JP-A-2) No. -53712
  • Patent Documents 3 to 7 JP-A 59-65008, JP-A 62-36308, JP-A 64-99911
  • Japanese Laid-Open Patent Publication No. 4-308525, Japanese Laid-Open Patent Publication No. 1-249711) and the like are known.
  • blending appropriate amounts of these components tends to improve the appearance of thinning hair, it is not fully satisfactory. If the blending amount of these components is increased in order to further improve the appearance of thinning hair, there is a problem that the skin feels sticky as a feeling of use, or the feeling of fluffiness decreases due to the hair becoming heavier. For this reason, when the blending amount is reduced, the usability is excellent, but there is a problem that a sufficient soft feeling cannot be imparted.
  • JP-A-60-243010 Japanese Patent Laid-Open No. 2-53712 JP 59-65008 A JP-A-62-36308 JP-A-64-9911 JP-A-4-308525 JP-A-1-249711
  • An object of the present invention is to provide a hair restorer composition that can restore the volume, has no stickiness of the background, and has an excellent feeling of use.
  • a hair-growth active ingredient (B) at least one selected from hydroxyethyl chitosan and hydroxypropyl chitosan, and (C) ethylene oxide
  • a hair-restoring composition comprising polyoxyethylene sorbite fatty acid ester having an average added mole number of 6 to 60 mol and (D) ethanol
  • hair strength (harkoshishi) is obtained by internal repair of hair with component (C).
  • moderately coating the outside of the hair with the component (B) gives a soft feeling before the hair growth and hair loss inhibiting effects are manifested, thus improving the appearance of thin and thin hair.
  • the hair growth and hair loss suppression effect is added to this, so that the entire volume of the hair can be restored, and it is also easy to use (no stickiness of the background). Heading the Rukoto, it has led to the completion of the present invention.
  • the present invention provides the following hair restorer composition.
  • A a hair-growth active ingredient;
  • B at least one selected from hydroxyethyl chitosan and hydroxypropyl chitosan;
  • C a polyoxyethylene sorbite fatty acid ester having an average addition mole number of ethylene oxide of 6 to 60 moles;
  • D A hair restorer composition comprising ethanol.
  • the hair restorer composition of the present invention can improve the appearance of thin hair by obtaining a soft feeling before the onset of the hair-growth effect, and can further increase the volume of the entire hair by adding hair-growth and hair loss inhibiting effects. It can be done without any stickiness of the surface and has an excellent feeling of use.
  • the hair restorer composition of the present invention comprises: (A) a hair-growth active ingredient; (B) at least one selected from hydroxyethyl chitosan and hydroxypropyl chitosan; (C) a polyoxyethylene sorbite fatty acid ester having an average addition mole number of ethylene oxide of 6 to 60 moles; (D) contains ethanol.
  • the component (A) used in the present invention is a known hair-growth active ingredient having a hair-growth effect and a hair loss-inhibiting effect.
  • a known hair-growth active ingredient having a hair-growth effect and a hair loss-inhibiting effect.
  • the above can be used in appropriate combination.
  • 6-benzylaminopurine, pentadecanoic acid glyceride and minoxidil are preferable from the viewpoint of hair growth effect, and 6-benzylaminopurine and pentadecanoic acid glyceride are more preferable.
  • Component (A) is blended in an amount of 0.1 to 5% by weight based on the total composition (plants such as assembly extract and coleus extract) from the viewpoints of hair loss improvement, non-stickiness of the skin, soft feeling, and hair growth effect.
  • the amount of pure extract is preferable, and more preferably 0.5 to 3% by mass.
  • (B) Chitosan (B) component is at least 1 sort (s) chosen from hydroxyethyl chitosan and hydroxypropyl chitosan, and a soft feeling can be improved notably by using with (C) component. Moreover, it is excellent in solubility and good appearance stability can be obtained.
  • the blending amount of the component (B) is preferably 0.11 to 0.19% by mass, more preferably 0.13 to 0.17% by mass with respect to the total amount of the composition from the viewpoint of softness and non-stickiness of the background. %. If it is less than 0.11% by mass, the soft feeling may be inferior, and if it exceeds 0.19% by mass, the non-stickiness of the background and the soft feeling may be inferior.
  • Component (C) is a polyoxyethylene sorbite fatty acid ester having an average added mole number of ethylene oxide of 6 to 60 mol, particularly 30 to 40, and when used together with component (B), the soft feeling is drastically increased. Can do.
  • Examples of the component (C) include monolauric acid polyoxyethylene sorbit, hexastearic acid polyoxyethylene sorbit, tetraoleic acid polyoxyethylene sorbit, etc., which may be used alone or in combination of two or more. .
  • tetraoxyoleic acid polyoxyethylene sorbite having an average addition mole number of ethylene oxide of 6 to 60 moles is preferable from the viewpoint of imparting a soft feeling, and more preferably an average addition mole number of ethylene oxide of 30 to 40 moles.
  • This is a polyoxyethylene sorbite of tetraoleate.
  • the soft feeling is inferior, and it is 6 moles or more from the viewpoint of availability.
  • Component (C) is preferably blended in an amount of 0.1 to 1.0% by weight, more preferably 0.2 to 0.5% by weight, based on the total amount of the composition, in terms of softness and non-stickiness of the background. preferable. If it is less than 0.1% by mass, the soft feeling may be inferior, and if it exceeds 1.0% by mass, the stickiness of the background and the soft feeling may be inferior.
  • [(D) ethanol] Ethanol is blended in order to enhance the solubility of hair growth active ingredients and the like, and to improve the non-stickiness of the background.
  • Examples of ethanol include absolute ethanol and 95% by volume ethanol. From the standpoints of solubility of hair growth active ingredient and associated hair loss improvement, soft feeling, hair growth effect, and non-stickiness of the surface, the blending amount of component (D) is 60-90 as absolute ethanol relative to the total amount of the composition. % By mass is preferable, and more preferably 65 to 80% by mass.
  • this compounding quantity is a compounding quantity containing the ethanol brought in from these extracts, when extracts, such as a plant extract, are mix
  • an optional component other than the above-mentioned components that are usually blended in the hair restorer composition is used alone or in combination of two or more, as long as the effects of the present invention are not impaired.
  • Such components include nonionic surfactants other than the component (C), semipolar surfactants, amphoteric surfactants, anionic polymers, nonionic polymers, polyols, organic salts, humectants, and tonic agents.
  • Solubilizers antioxidants such as dibutylhydroxytoluene (BHT), bactericides such as triclosan and trichlorocarban, viscosity modifiers such as fatty acid monoethanolamide and fatty acid diethanolamide, UV absorbers, antioxidants, protein derivatives Animal and plant extracts, anti-dandruff agents such as piroctone olamine and zinc pyrithione, anti-inflammatory agents such as dipotassium glycyrrhizinate and glycol salicylate, benzoic acid and its salts, transdermal absorption promoters such as polyethylene glycol and lauryl lactate, parabens , P of antiseptics such as caisson CG, citric acid, triethanolamine, etc.
  • antioxidants such as dibutylhydroxytoluene (BHT)
  • bactericides such as triclosan and trichlorocarban
  • viscosity modifiers such as fatty acid monoethanolamide and fatty acid diethanolamide
  • pearlizing agent such as ethylene glycol difatty acid ester, emulsion, hydrotrope, vitamins, volatile oil, hydrophobic solvent, diluting solvent, extracts such as pepper extract and pepper tincture, l-menthol And other refreshing agents, pigments, and fragrances.
  • the hair restorer composition of the present invention can be widely used as a hair restorer, a hair nourishing agent, a blood circulation promoter, and a hair loss improving agent, and is particularly preferably used as a hair restorer.
  • it can be used for external use in the form of hair-growth tonic, scalp essence, hair-growth spray, hair-growth hair gel, etc., and it can be applied to both the scalp and hair (particularly thin hair and hair root) to achieve hair-growth effect.
  • a sufficient volume can be given to the entire hair by the soft feeling effect from the root.
  • the hair restorer composition of the present invention can be obtained based on a conventional method by mixing the above essential components and optional components.
  • Examples of the container filled with the hair growth composition of the present invention include a dispenser container and a squeeze container by mechanical or differential pressure, a laminate film container, a dropper container, a bottle container and the like.
  • the bottle material polyethylene, polypropylene, polyethylene terephthalate, polystyrene, polyvinyl chloride, ethylene-vinyl alcohol resin, acrylonitrile / styrene resin, ABS resin, polyamide, glass, etc. can be used in a single layer or a combination of two or more layers. In particular, polyethylene is preferred.
  • (D) ethanol is the quantity as absolute ethanol
  • the compounding quantity of (D) ethanol shows the whole quantity contained in a composition.
  • solid amounts were shown, and with respect to other plant extracts, the amount of pure extract was shown.
  • the compounding quantity of components other than ethanol and a plant extract is a pure part conversion amount.
  • Examples 1 to 26, Comparative Examples 1 to 9 A hair restorer composition having the composition shown in the following table was prepared according to a conventional method and evaluated by the following method. The results are also shown in the table.
  • ⁇ Evaluation method 10 females in their 40s and 60s were evaluated whether the scalp (scalp) was sticky after using the hair restorer composition for 14 days after shampooing, drying, and before using the hair restorer. . If the evaluation score is 3 points or more, the non-stickiness of the background is good.
  • ⁇ Evaluation criteria 5 points: 9 or more out of 10 responded that they did not feel sticky on the ground 4 points: 7 to 8 out of 10 responded that they did not feel sticky on the ground 3 points: 5 out of 10 6 or more people answered that they did not feel sticky on the skin 2 points: 3 or more of 10 people answered that they did not feel sticky on the skin 1 point: 2 or less people out of 10 Answer that the skin is not sticky

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une composition d'agents de croissance capillaire contenant (A) un principe actif de croissance capillaire, (B) au moins un composé choisi parmi chitosane hydroxyéthyle et chitosane hydroxypropyle, (C) un ester d'acide gras de polyoxyéthylène sorbitane dans lequel le nombre moyen de moles d'oxyde d'éthylène ajouté est compris entre 6 et 60 moles, et (D) l'éthanol.
PCT/JP2014/062869 2013-05-15 2014-05-14 Composition d'agents de croissance capillaire WO2014185461A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201480025097.XA CN105163717B (zh) 2013-05-15 2014-05-14 生发剂组合物
KR1020157025699A KR102164151B1 (ko) 2013-05-15 2014-05-14 육모제 조성물
JP2015517114A JP6172269B2 (ja) 2013-05-15 2014-05-14 育毛剤組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013-103132 2013-05-15
JP2013103132 2013-05-15

Publications (1)

Publication Number Publication Date
WO2014185461A1 true WO2014185461A1 (fr) 2014-11-20

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ID=51898437

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2014/062869 WO2014185461A1 (fr) 2013-05-15 2014-05-14 Composition d'agents de croissance capillaire

Country Status (4)

Country Link
JP (1) JP6172269B2 (fr)
KR (1) KR102164151B1 (fr)
CN (1) CN105163717B (fr)
WO (1) WO2014185461A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019142851A (ja) * 2018-02-16 2019-08-29 花王株式会社 育毛剤

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111110618B (zh) * 2020-02-11 2022-09-27 张运适 一种用于促进毛发生长的组合物
CN111494265A (zh) * 2020-05-22 2020-08-07 广东创美抗衰老研究有限公司 银耳修护补水面膜

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JPH11193219A (ja) * 1997-12-26 1999-07-21 Ichimaru Pharcos Co Ltd 植物抽出物配合養毛・育毛剤
JP2007008867A (ja) * 2005-06-30 2007-01-18 Lion Corp 毛髪化粧料
WO2008035563A1 (fr) * 2006-09-21 2008-03-27 Lion Corporation Cosmétique capillaire
JP2008120792A (ja) * 2006-10-16 2008-05-29 Hayashibara Biochem Lab Inc 保湿・整髪作用を有する皮膚及び毛髪用化粧料とその製造方法
JP2012184220A (ja) * 2011-02-17 2012-09-27 Lion Corp 頭皮頭髪化粧料

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DE3233388C2 (de) 1982-09-09 1988-06-16 Beiersdorf Ag, 2000 Hamburg Verwendung von Sericin in haarkosmetischen Mitteln und Badezusatzpräparaten
JPS60243010A (ja) 1984-05-17 1985-12-03 Seiwa Kasei:Kk 毛髪保護剤
JPS6236308A (ja) 1985-08-12 1987-02-17 Kishiyuu Sangyo Kk セリシン加水分解液組成物を配合した化粧料
JPS649911A (en) 1987-06-30 1989-01-13 Lion Corp Hair cosmetic
JP2598954B2 (ja) 1988-03-30 1997-04-09 三洋化成工業株式会社 整髪料組成物
JP2878287B2 (ja) 1988-08-12 1999-04-05 株式会社成和化成 化粧品基材
JP2779555B2 (ja) 1991-04-05 1998-07-23 花王株式会社 毛髪化粧料
JP4133639B2 (ja) * 2003-07-16 2008-08-13 ライオン株式会社 養育毛剤組成物
JP4812304B2 (ja) * 2005-01-21 2011-11-09 第一三共ヘルスケア株式会社 毛髪用組成物
JP2007191473A (ja) * 2005-12-21 2007-08-02 Daiichi Sankyo Healthcare Co Ltd 新規な育毛用組成物
JP2007169233A (ja) * 2005-12-26 2007-07-05 Lion Corp 養育毛剤組成物
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11193219A (ja) * 1997-12-26 1999-07-21 Ichimaru Pharcos Co Ltd 植物抽出物配合養毛・育毛剤
JP2007008867A (ja) * 2005-06-30 2007-01-18 Lion Corp 毛髪化粧料
WO2008035563A1 (fr) * 2006-09-21 2008-03-27 Lion Corporation Cosmétique capillaire
JP2008120792A (ja) * 2006-10-16 2008-05-29 Hayashibara Biochem Lab Inc 保湿・整髪作用を有する皮膚及び毛髪用化粧料とその製造方法
JP2012184220A (ja) * 2011-02-17 2012-09-27 Lion Corp 頭皮頭髪化粧料

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019142851A (ja) * 2018-02-16 2019-08-29 花王株式会社 育毛剤
JP7213713B2 (ja) 2018-02-16 2023-01-27 花王株式会社 育毛剤

Also Published As

Publication number Publication date
KR102164151B1 (ko) 2020-10-12
KR20160021427A (ko) 2016-02-25
JPWO2014185461A1 (ja) 2017-02-23
CN105163717B (zh) 2017-10-27
JP6172269B2 (ja) 2017-08-02
CN105163717A (zh) 2015-12-16

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