WO2014097973A1 - 自動分析装置 - Google Patents
自動分析装置 Download PDFInfo
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- WO2014097973A1 WO2014097973A1 PCT/JP2013/083406 JP2013083406W WO2014097973A1 WO 2014097973 A1 WO2014097973 A1 WO 2014097973A1 JP 2013083406 W JP2013083406 W JP 2013083406W WO 2014097973 A1 WO2014097973 A1 WO 2014097973A1
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- WIPO (PCT)
- Prior art keywords
- sample
- reagent
- automatic analyzer
- dispensing
- discharge speed
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1002—Reagent dispensers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
- B01F23/451—Mixing liquids with liquids; Emulsifying using flow mixing by injecting one liquid into another
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00534—Mixing by a special element, e.g. stirrer
- G01N2035/00544—Mixing by a special element, e.g. stirrer using fluid flow
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N2035/00891—Displaying information to the operator
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N2035/00891—Displaying information to the operator
- G01N2035/0091—GUI [graphical user interfaces]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
- G01N2035/1018—Detecting inhomogeneities, e.g. foam, bubbles, clots
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
- G01N2035/1058—General features of the devices using the transfer device for another function for mixing
Definitions
- the present invention relates to an automatic analyzer that automatically analyzes components of biological samples such as blood, and more particularly to a method of stirring a sample and a reagent used for blood coagulation measurement such as blood agglutination reaction.
- an analyzer that analyzes the amount of components contained in a sample, it measures the amount of transmitted or scattered light with a single or multiple wavelengths obtained by irradiating light from a light source onto a reaction mixture in which the sample and reagent are mixed.
- an automatic analyzer that calculates the amount of a component from the relationship between light quantity and density is known.
- reaction solutions There are roughly two types of analysis methods for reaction solutions, colorimetric analysis using a color reaction between a substrate and an enzyme, and homogeneous immunoassay using an agglutination reaction by binding of an antigen and an antibody.
- homogeneous immunoassay measurement methods such as immunoturbidimetry and latex agglutination are known.
- a heterogeneous immunoassay apparatus that performs more sensitive immunoassay by a detection technique using chemiluminescence or electrochemiluminescence and a B / F separation technique is also known.
- Such blood coagulation ability includes an exogenous one that coagulates blood leaked out of the blood vessel and an intrinsic one that coagulates blood inside the blood vessel.
- Measurement items related to blood coagulation ability include prothrombin time (PT) in the extrinsic blood coagulation reaction test, activated partial thromboplastin time (APTT) in the intrinsic blood coagulation reaction test, and fibrinogen amount (Fbg).
- PT prothrombin time
- APTT activated partial thromboplastin time
- Fbg fibrinogen amount
- These items are based on detecting fibrin precipitated by adding a reagent that initiates coagulation by an optical, physical, or electrical technique.
- the reaction solution is irradiated with light, and the fibrin deposited in the reaction solution is detected by measuring the intensity change over time of scattered light or transmitted light, so that the time when fibrin starts to precipitate can be increased.
- a method of calculating is known. Since the coagulation time of blood coagulation reaction (especially Fbg item) is as short as several seconds, it is necessary to perform photometry at intervals as short as 0.1 second, and when the reaction solution coagulates, the reuse of the reaction vessel by washing is Since this is not possible, the reaction takes place in an independent photometric port and the reaction vessel is disposable.
- the reaction container is installed in a holder that rotates in a conical manner. Immediately after detecting that the reagent has been dispensed, the reaction container for each holder is rotated, and the sample, the reagent, Is being stirred. With this method, a mechanism for rotating the reaction vessel is required, and it is assumed that the number of parts increases, the structure becomes complicated, and the apparatus becomes expensive.
- Patent Document 2 the reaction vessel is swung to stir the sample and the reagent.
- a pendulum motion, a reciprocating motion, an eccentric rotational motion, or a combined motion in which two or more of these are combined is performed.
- it seems that the stirring is more uniform and more reproducible with a more complicated movement than (Patent Document 1), but it is undeniable that the structure becomes complicated accordingly.
- Patent Document 3 when a reagent is dispensed into a sample in a specimen container, the sample is aspirated by the reagent dispensing probe when the reagent dispensing probe reaches the sample liquid level using liquid level detection.
- the sample is stirred by repeating the discharge a plurality of times. In this case, it is likely that stirring can be performed efficiently, but there is a high possibility that the reagent probe is contaminated with the sample. Further, in the case of an apparatus in which a sample container or a reaction container is held on a rotating disk, the disk rotation must be stopped for a certain period of time to perform suction and discharge operations, which may cause a reduction in processing capacity.
- the amount of sample and the amount of reagent vary depending on the item, and it may be difficult to mix depending on the combination. For example, when there are more samples to be dispensed in the reaction container earlier than the reagent to be dispensed next, it is assumed that sufficient stirring cannot be achieved with the discharge pressure of the reagent, and vice versa. Therefore, it is necessary to agitate by a pressure and a discharge method so as to avoid bubbles while making the reaction of the entire reaction solution uniform.
- the typical configuration of the present invention is as follows.
- a reaction vessel for reacting the sample with the reagent for reacting the sample with the reagent, a detection unit for detecting light irradiated to the reaction solution in the reaction vessel, a reagent dispensing mechanism for dispensing the reagent into the reaction vessel, and a sample in the reaction vessel
- a sample dispensing mechanism for dispensing and a control unit for controlling the reagent dispensing mechanism and the sample dispensing mechanism, wherein the control unit is one of the reagent dispensing mechanism and the sample dispensing mechanism.
- a predetermined amount of liquid is discharged into the reaction container first, and the amount of liquid discharged in the case where the amount of liquid discharged by the other dispensing mechanism is larger or smaller than the amount of liquid in the reaction container. This is an automatic analyzer that discharges by relatively lowering the discharge speed when the amount is large compared to the discharge speed when the amount is small.
- sample dispensing mechanism is equipped with a pressure sensor that allows observation of pressure fluctuations in the flow path.
- the pressure fluctuation during sample suction changes the discharge speed of the sample or reagent according to the viscosity. It is an automatic analyzer.
- the automatic analyzer includes a plurality of detection units including a reaction vessel setting unit for placing a reaction vessel for reacting a sample and a reagent, and a reaction vessel
- the light source which irradiates light provided in the bottom part or side of an installation part, and the detector provided in the reaction container installation part and which detects the scattered light from the said reaction container of the light irradiated from the light source are provided.
- the detector When there is a light source on the bottom, the detector is placed beside the reaction vessel and receives scattered light from the bottom, or when there is a light source beside the reaction vessel, it is placed at a position to receive the light source orthogonally Is done.
- a dispensing mechanism that is movable in the vertical and rotational directions or in the horizontal direction.
- a sample probe and a syringe pump there are a sample probe and a syringe pump, and each of the sample and the reagent is dispensed from the dispensing mechanism to the reaction container. Either the sample or the reagent is dispensed first into the reaction container, and the reaction solution is stirred by dispensing either one later. The blood coagulation reaction time is measured by the change in the amount of the reaction solution.
- an operation unit connected to the apparatus, and a dispensing amount, a dispensing speed, a dispensing ratio, and the like are displayed on the operation screen, and the dispensing speed can be changed on the operation screen.
- sample viscosity level and the like are displayed on the screen from the pressure fluctuation during sample suction, and a dispensing speed set in advance according to the viscosity is displayed. If there is any need, the dispensing speed may be changeable on the operation screen.
- the present invention it is possible to reduce foaming of the reaction solution and uniformly stir the entire reaction solution. As a result, the heterogeneity of the blood agglutination reaction measurement can be suppressed, and a highly accurate measurement result can be obtained.
- FIG. 1 shows one example of a general blood coagulation apparatus configuration. Since the function of each part is well-known, detailed description is omitted.
- the sampling arm 102 of the sampling mechanism 101 moves up and down and rotates, and the sample dispensing probe 103 attached to the sampling arm 102 is used to suck the sample in the sample container 105 disposed on the sample disk 104 that rotates left and right. , And is configured to be discharged into the reaction vessel 106.
- the sample dispensing probe 103 performs a sample suction operation and a discharge operation in accordance with the operation of the sample syringe pump 107.
- a pressure sensor 130 is provided in the flow path, and mainly monitors pressure fluctuation during suction.
- the reagent dispensing arm 109 moves up and down and rotates so that the reagent dispensing probe 110 sucks the sample in the reagent container 112 arranged on the reagent disk 111 and discharges it to the reaction container 106.
- the reagent temperature raising mechanism 113 is built in. The sample discharged into the reaction vessel 106 reacts with the reagent.
- the reagent dispensing probe 110 performs a reagent suction operation and a discharge operation in accordance with the operation of the reagent syringe pump 114.
- the reaction vessel 106 is held by the reaction vessel holding unit 118 of the reaction vessel carry-out mechanism 117 that rotates from the reaction vessel stock unit 115, rotates, and is installed in the reaction vessel installation unit 120 of the detection unit 119.
- the reaction vessel installation unit 120 is provided with a recess so that the reaction vessel 106 can be placed, and the reaction vessel 106 can be inserted into this recess.
- there are a plurality of reaction vessel installation sections 120 and this apparatus includes a plurality of detection sections 119.
- the reaction container transport mechanism 117 is a mechanism common to a plurality of detection units that grips the reaction container 106 and transports and installs the reaction container 106.
- analysis items to be analyzed for each sample are input from an input device such as a keyboard 121 or a CRT 122 screen.
- the operation of the unit is controlled by a computer (control unit) 123.
- the sample dispensing mechanism 101 sucks the sample in the sample container 105 disposed on the sample disk 104 and dispenses it to the reaction container 106 placed on the reaction container setting unit 120 in the detection unit 119.
- the reagent is similarly sucked from the reagent container 112 arranged on the reagent disk 111 by the reagent dispensing mechanism 108, heated to an appropriate temperature by the reagent heating mechanism 113, and dispensed to the reaction container 106.
- the blood coagulation reaction is immediately started at this reagent discharge pressure.
- Light from the light source 124 is irradiated onto the reaction vessel 106, and the scattered light scattered by the reaction solution in the reaction vessel is detected by a detection unit 125 such as a photodiode.
- the photometric signal passes through the A / D converter 126.
- the computer (control unit) 123 is entered via the interface 127, and the coagulation reaction time is calculated.
- the result is printed out to the printer 128 via the interface 127 or output to the CRT 122 and stored in the hard disk 129 as a memory.
- the reaction vessel 106 for which photometry has been completed is held by the reaction vessel transport mechanism 117 and discarded to the reaction vessel disposal unit 116.
- FIG. 2 is an example of a dispensing method in blood clotting reaction measurement.
- an apparatus for reacting a reaction solution such as blood coagulation by stirring only with a liquid discharge pressure, dispenses either a sample 202 or a reagent 203 into a reaction vessel 200 in advance using a dispensing probe 201. Set aside, then dispense the remaining one. At this time, each is mixed and stirred in the reaction container by the discharge pressure of the liquid dispensed second, and the reaction proceeds.
- the mixing ratio of the sample and the reagent is various, such as the same amount, when there are more samples and when there are more reagents.
- the required sample is about 5-50 ul
- the reagent is about 20-250 ul
- the combinations vary depending on the item. If the sample and reagent are about the same amount, it is considered relatively easy to mix uniformly. However, if the amount of liquid dispensed first is larger than the amount of liquid to be discharged next, the same amount It is hard to mix compared with the time. On the contrary, when the amount of liquid dispensed earlier is smaller than the amount of liquid to be discharged next, bubbles are likely to be generated depending on the discharge speed although it depends on the liquid property. Therefore, by changing the discharge speed according to the amount of the sample and the reagent, a uniform reaction without disturbance such as bubbles is promoted, and as a result, more reliable measurement is possible.
- FIG. 3 is a diagram showing an example of the discharge speed control.
- the vertical axis indicates the coagulation time, and the horizontal axis indicates the discharge speed.
- the discharge amount is constant.
- the average point of n times of measurement data is taken, and the maximum and minimum values are displayed as error bars.
- the solidification time and the discharge speed are inversely proportional, and the data is not stable, indicating that sufficient agitation is not performed.
- the coagulation time is also stable and the data variation is small. Therefore, it is considered that the data was sufficiently stirred and stable data was obtained.
- discharge speed 7.5 or more discharge speed 7.5 or more
- the coagulation time is equal to the above, but the fluctuation range of the data becomes large. This is thought to be due to the mixing of bubbles due to the discharge pressure, affecting the optical change, and increasing the variation. Therefore, when changing the discharge speed relatively depending on the mixing ratio of the sample and the reagent, it is necessary to select and relatively control the discharge speed with the best data reproducibility according to each discharge condition. .
- FIG. 4 shows an example of controlling the discharge speed using the mixing ratio of the sample and the reagent, and shows simplified control with reference to the above result.
- the discharge speed at the mixing ratio of 1: 1 is medium
- the discharge speed becomes the minimum, weak, small, medium, large, strong, and maximum in order from the top.
- each speed is determined within a speed range with the best data reproducibility according to each condition.
- FIG. 4 shows the discharge speed in seven stages.
- the discharge speed is not limited to the seven stages, and the control unit is arranged in one of the reagent dispensing mechanism and the sample dispensing mechanism in the reaction container. Discharge the predetermined liquid amount (first dispensing liquid amount) first, and the amount of liquid discharged by the other dispensing mechanism (second dispensing liquid amount) is small compared to the liquid amount in the reaction vessel.
- the effect of the invention can be obtained even when the discharge speed is changed in two stages so that the discharge speed is relatively lowered when the discharge liquid amount is large.
- FIG. 5 is an example of a fluctuation waveform at the time of sample suction of the pressure sensor 130 provided in the sample suction mechanism.
- A is an example of a waveform when a normal or general specimen is aspirated. The pressure decreases simultaneously with the start of sample suction, and changes gently in the sample suction section. When the suction is completed, the pressure on the negative pressure side returns to the atmospheric pressure.
- B is an example of a waveform when a highly viscous sample is sucked. Compared with (a), the suction section is greatly changed to the negative pressure side, and the time until the return to the atmospheric pressure is long even after the suction section ends.
- the pressure change at this time is influenced by the sample properties such as the viscosity and density of the sample and the suction speed. Therefore, if the suction speed is constant, the degree of viscosity / density of the sample appears in the waveform, and the pressure fluctuation is effective as an element indicating the degree of viscosity.
- FIG. 6 is an example of a method for controlling the dispensing speed to which the sample viscosity parameter is added when the first dispensing is used as a sample with respect to FIG.
- Samples vary in viscosity due to individual differences, and samples with high viscosity are less likely to mix as compared to standard ones, and there is a high possibility that stirring will be insufficient. Therefore, it is necessary to control the discharge speed in consideration of not only the discharge speed according to the ratio of the sample and the reagent amount but also the sample viscosity.
- the discharge speed is set low, but the discharge speed is set low.
- the discharge speed can be reduced from the minimum to the low, from the low to the low. Or, change from small to medium. That is, the control unit discharges the reagent at a relatively high discharge speed.
- the discharge speed is increased from large to strong if the viscosity of the first dispensing is relatively high even if the ratio is the same liquid amount, or Change from strong to maximal. That is, the control unit discharges the reagent at a relatively high discharge speed.
- the stirring performance can be further improved by changing the discharge speed using the mixing ratio of the sample and the reagent and the sample viscosity as parameters.
- Fig. 7 is a screen display example of discharge speed, dispensing ratio, etc.
- a display example in the case where the sample is first discharged into the reaction container and then the reagent is dispensed is shown.
- the item name and the amount of sample / reagent dispensed are displayed on a screen as shown in the figure.
- the dispensing ratio is automatically calculated and displayed.
- the discharge speed or the degree of the discharge speed is automatically selected based on a predetermined setting and displayed on the screen.
- the level of the discharge speed is displayed in three levels of strong, medium, and weak, but the discharge speed may be displayed as a numerical value.
- the discharge speed may be selected from the selection button on the screen and changed.
- the speed may be a selection button or a numerical value input on the screen.
- a mechanism may be used in which only the display is performed and the speed cannot be changed.
- the sample viscosity calculated from the pressure fluctuation at the time of sample suction is displayed on the screen, and the discharge speed or the degree of the discharge speed is automatically selected based on the predetermined setting and displayed on the screen.
- Reaction container installation position 121 ... Keyboard, 122 ... CRT, 123 ... Contributor, 124 ... Light source, 125 ... Detector, 126 ... A / D Transducer, 127 ... Interface, 128 ... Printer, 129 ... Memory, 130 ... Pressure sensor, 200 ... Reaction vessel, 201 ... Dispensing probe, 202 ... Sample, 203 ... Reagent
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Abstract
Description
Claims (9)
- 試料と試薬とを反応させる反応容器と、
前記反応容器内の反応溶液に照射した光を検出する検出部と、
前記反応容器に試薬を分注する試薬分注機構と、
前記反応容器に試料を分注する試料分注機構と、
前記試薬分注機構と前記試料分注機構を制御する制御部とを備え、
前記制御部は、前記試薬分注機構と前記試料分注機構のいずれか一方の分注機構で、前記反応容器に先に所定の液量を吐出し、前記反応容器内の液量に対し、他方の分注機構で吐出する液量が多い場合と少ない場合とで、吐出液量が多い場合の吐出速度を少ない場合の吐出速度に比べ相対的に下げて吐出することを特徴とする自動分析装置。 - 請求項1記載の自動分析装置において、
前記制御部は、試料と試薬の混合割合に応じて3種類以上の吐出速度で制御することを特徴とする自動分析装置。 - 請求項1記載の自動分析装置において
試料と試薬との分注割合を操作画面上に表示することを特徴とする自動分析装置。 - 請求項3記載の自動分析装置において、
さらに、吐出速度又は吐出速度の程度を前記操作画面上に表示することを特徴とする自動分析装置。 - 請求項4記載の自動分析装置において、
吐出速度を前記操作画面上から変更することが可能であることを特徴とする自動分析装置。 - 請求項1記載の自動分析装置において、
他の攪拌手段を用いずに、前記他方の分注機構における吐出圧で試料と試薬とを攪拌することを特徴とする自動分析装置。 - 請求項1記載の自動分析装置において、
さらに、前記試料分注機構に試料の吸引時の圧力変動を観察する圧力センサを備え、
前記圧力センサの前記圧力変動から得られる粘度の高さに応じて、吐出速度を変化させることを特徴とする自動分析装置。 - 請求項7記載の自動分析装置において、
試料と試薬の混合割合と、試料粘度をパラメータとして、吐出速度を変化させることを特徴とする自動分析装置。 - 請求項7記載の自動分析装置において、
試料と試薬との分注割合、及び試料粘度を操作画面上に表示することを特徴とする自動分析装置。
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
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US14/651,026 US9846171B2 (en) | 2012-12-19 | 2013-12-13 | Automated analyzer |
JP2014553104A JP5911603B2 (ja) | 2012-12-19 | 2013-12-13 | 自動分析装置 |
CN201380065291.6A CN104854459B (zh) | 2012-12-19 | 2013-12-13 | 自动分析装置 |
EP13865612.9A EP2937700B1 (en) | 2012-12-19 | 2013-12-13 | Automated analyzer |
US15/837,181 US10520522B2 (en) | 2012-12-19 | 2017-12-11 | Automated analyzer |
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JP2012276355 | 2012-12-19 | ||
JP2012-276355 | 2012-12-19 |
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US14/651,026 A-371-Of-International US9846171B2 (en) | 2012-12-19 | 2013-12-13 | Automated analyzer |
US15/837,181 Division US10520522B2 (en) | 2012-12-19 | 2017-12-11 | Automated analyzer |
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WO2014097973A1 true WO2014097973A1 (ja) | 2014-06-26 |
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PCT/JP2013/083406 WO2014097973A1 (ja) | 2012-12-19 | 2013-12-13 | 自動分析装置 |
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US (2) | US9846171B2 (ja) |
EP (1) | EP2937700B1 (ja) |
JP (2) | JP5911603B2 (ja) |
CN (2) | CN107290558B (ja) |
WO (1) | WO2014097973A1 (ja) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016161295A (ja) * | 2015-02-26 | 2016-09-05 | 株式会社日立ハイテクノロジーズ | 自動分析装置及び試料希釈攪拌方法 |
JP2016166876A (ja) * | 2012-12-19 | 2016-09-15 | 株式会社日立ハイテクノロジーズ | 自動分析装置および分析方法 |
JP2016217921A (ja) * | 2015-05-22 | 2016-12-22 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
WO2018163917A1 (ja) | 2017-03-08 | 2018-09-13 | 株式会社日立ハイテクノロジーズ | 自動分析装置及び自動分析方法 |
JP2019174485A (ja) * | 2019-07-10 | 2019-10-10 | 株式会社日立ハイテクノロジーズ | 自動分析装置及び試料希釈攪拌方法 |
JPWO2021084997A1 (ja) * | 2019-10-30 | 2021-05-06 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109975562A (zh) * | 2017-12-28 | 2019-07-05 | 深圳市新产业生物医学工程股份有限公司 | 化学发光检测仪及其检测方法 |
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06341999A (ja) * | 1993-06-02 | 1994-12-13 | Olympus Optical Co Ltd | 液体試料分注装置 |
JPH1073532A (ja) | 1996-08-29 | 1998-03-17 | Toa Medical Electronics Co Ltd | 液体試料測定装置 |
JPH1073540A (ja) | 1996-08-29 | 1998-03-17 | Toa Medical Electronics Co Ltd | 液体試料測定装置 |
JP2006317472A (ja) * | 2006-09-04 | 2006-11-24 | Toshiba Corp | 自動分析装置 |
JP2008298494A (ja) * | 2007-05-30 | 2008-12-11 | Hitachi High-Technologies Corp | 分注装置 |
JP2009002752A (ja) * | 2007-06-20 | 2009-01-08 | Iwashita Engineering Inc | 液体調合装置 |
JP2011128075A (ja) | 2009-12-18 | 2011-06-30 | Beckman Coulter Inc | 自動分析装置、自動分析装置の検体攪拌方法および検体分注方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56164957A (en) * | 1980-05-23 | 1981-12-18 | Aloka Co Ltd | Automatic dispenser |
JPS6317459U (ja) * | 1986-07-18 | 1988-02-05 | ||
JPH0599933A (ja) * | 1991-02-15 | 1993-04-23 | Olympus Optical Co Ltd | 多項目自動分析装置 |
JP2795564B2 (ja) * | 1991-10-08 | 1998-09-10 | アロカ 株式会社 | 高粘性液体の希釈方法 |
JP3328048B2 (ja) * | 1994-02-25 | 2002-09-24 | 富士写真フイルム株式会社 | 液体の混合方法 |
JPH0875755A (ja) * | 1994-09-09 | 1996-03-22 | Toshiba Corp | 自動分析装置 |
JPH1096735A (ja) * | 1996-09-25 | 1998-04-14 | Aloka Co Ltd | 空中吐出式分注装置 |
US5857589A (en) * | 1996-11-20 | 1999-01-12 | Fluid Research Corporation | Method and apparatus for accurately dispensing liquids and solids |
JP2000065843A (ja) * | 1998-08-20 | 2000-03-03 | Matsushita Electric Ind Co Ltd | 自動分注装置および分注方法 |
JP3866446B2 (ja) * | 1999-05-07 | 2007-01-10 | 株式会社東芝 | 自動分析装置 |
JP4635138B2 (ja) | 1999-09-10 | 2011-02-16 | アークレイ株式会社 | 特定成分の分析方法 |
JP4786087B2 (ja) * | 2001-09-13 | 2011-10-05 | ベックマン コールター, インコーポレイテッド | 分注すべき液体の分注装置 |
JP4251627B2 (ja) * | 2003-09-19 | 2009-04-08 | 株式会社東芝 | 化学分析装置及びその分注方法 |
JP4773750B2 (ja) | 2005-06-09 | 2011-09-14 | ベックマン コールター, インコーポレイテッド | 分注装置、分注方法および分析装置 |
JP5035941B2 (ja) * | 2005-06-09 | 2012-09-26 | ベックマン コールター, インコーポレイテッド | 分注装置、分注方法および分析装置 |
WO2006132114A1 (ja) * | 2005-06-09 | 2006-12-14 | Olympus Corporation | 分注装置、分注方法および分析装置 |
JP4891749B2 (ja) * | 2006-12-12 | 2012-03-07 | 株式会社東芝 | 自動分析装置 |
JP2008197037A (ja) * | 2007-02-15 | 2008-08-28 | Yaskawa Electric Corp | 分注装置およびそのコントローラと分注方法 |
JP4893685B2 (ja) * | 2007-07-26 | 2012-03-07 | 株式会社島津製作所 | 反応容器プレート及び反応処理方法 |
JP5277214B2 (ja) * | 2010-07-27 | 2013-08-28 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
EP2937700B1 (en) | 2012-12-19 | 2020-03-11 | Hitachi High-Technologies Corporation | Automated analyzer |
-
2013
- 2013-12-13 EP EP13865612.9A patent/EP2937700B1/en active Active
- 2013-12-13 CN CN201710587211.3A patent/CN107290558B/zh active Active
- 2013-12-13 JP JP2014553104A patent/JP5911603B2/ja active Active
- 2013-12-13 US US14/651,026 patent/US9846171B2/en active Active
- 2013-12-13 CN CN201380065291.6A patent/CN104854459B/zh active Active
- 2013-12-13 WO PCT/JP2013/083406 patent/WO2014097973A1/ja active Application Filing
-
2016
- 2016-03-29 JP JP2016065011A patent/JP2016166876A/ja active Pending
-
2017
- 2017-12-11 US US15/837,181 patent/US10520522B2/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06341999A (ja) * | 1993-06-02 | 1994-12-13 | Olympus Optical Co Ltd | 液体試料分注装置 |
JPH1073532A (ja) | 1996-08-29 | 1998-03-17 | Toa Medical Electronics Co Ltd | 液体試料測定装置 |
JPH1073540A (ja) | 1996-08-29 | 1998-03-17 | Toa Medical Electronics Co Ltd | 液体試料測定装置 |
JP2006317472A (ja) * | 2006-09-04 | 2006-11-24 | Toshiba Corp | 自動分析装置 |
JP2008298494A (ja) * | 2007-05-30 | 2008-12-11 | Hitachi High-Technologies Corp | 分注装置 |
JP2009002752A (ja) * | 2007-06-20 | 2009-01-08 | Iwashita Engineering Inc | 液体調合装置 |
JP2011128075A (ja) | 2009-12-18 | 2011-06-30 | Beckman Coulter Inc | 自動分析装置、自動分析装置の検体攪拌方法および検体分注方法 |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016166876A (ja) * | 2012-12-19 | 2016-09-15 | 株式会社日立ハイテクノロジーズ | 自動分析装置および分析方法 |
US9846171B2 (en) | 2012-12-19 | 2017-12-19 | Hitachi High-Technologies Corporation | Automated analyzer |
US10520522B2 (en) | 2012-12-19 | 2019-12-31 | Hitachi High-Technologies Corporation | Automated analyzer |
JP2016161295A (ja) * | 2015-02-26 | 2016-09-05 | 株式会社日立ハイテクノロジーズ | 自動分析装置及び試料希釈攪拌方法 |
JP2016217921A (ja) * | 2015-05-22 | 2016-12-22 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
WO2018163917A1 (ja) | 2017-03-08 | 2018-09-13 | 株式会社日立ハイテクノロジーズ | 自動分析装置及び自動分析方法 |
JPWO2018163917A1 (ja) * | 2017-03-08 | 2019-11-07 | 株式会社日立ハイテクノロジーズ | 自動分析装置及び分析方法 |
US11231432B2 (en) | 2017-03-08 | 2022-01-25 | Hitachi High-Tech Corporation | Automatic analysis device and automatic analysis method |
JP2019174485A (ja) * | 2019-07-10 | 2019-10-10 | 株式会社日立ハイテクノロジーズ | 自動分析装置及び試料希釈攪拌方法 |
JPWO2021084997A1 (ja) * | 2019-10-30 | 2021-05-06 | ||
WO2021084997A1 (ja) * | 2019-10-30 | 2021-05-06 | 東洋紡株式会社 | 有形成分分析装置およびプログラム |
JP7259984B2 (ja) | 2019-10-30 | 2023-04-18 | 東洋紡株式会社 | 有形成分分析装置およびプログラム |
Also Published As
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CN107290558B (zh) | 2019-03-15 |
CN104854459A (zh) | 2015-08-19 |
US20180100871A1 (en) | 2018-04-12 |
JPWO2014097973A1 (ja) | 2017-01-12 |
EP2937700A1 (en) | 2015-10-28 |
US9846171B2 (en) | 2017-12-19 |
EP2937700B1 (en) | 2020-03-11 |
EP2937700A4 (en) | 2016-08-17 |
CN107290558A (zh) | 2017-10-24 |
US10520522B2 (en) | 2019-12-31 |
JP2016166876A (ja) | 2016-09-15 |
JP5911603B2 (ja) | 2016-04-27 |
US20150316570A1 (en) | 2015-11-05 |
CN104854459B (zh) | 2017-08-11 |
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