WO2014088182A1 - 천연 폴리페놀 화합물 함유 조성물 및 이를 포함하는 경구 섭취용 조성물 - Google Patents
천연 폴리페놀 화합물 함유 조성물 및 이를 포함하는 경구 섭취용 조성물 Download PDFInfo
- Publication number
- WO2014088182A1 WO2014088182A1 PCT/KR2013/006523 KR2013006523W WO2014088182A1 WO 2014088182 A1 WO2014088182 A1 WO 2014088182A1 KR 2013006523 W KR2013006523 W KR 2013006523W WO 2014088182 A1 WO2014088182 A1 WO 2014088182A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- natural polyphenol
- polyphenol compound
- saponin
- water
- Prior art date
Links
- -1 polyphenol compounds Chemical class 0.000 title claims abstract description 59
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- 150000007949 saponins Chemical class 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- compositions containing natural polyphenol compounds and compositions for oral ingestion are disclosed. More specifically, a composition containing a natural polyphenol compound having excellent water dispersibility or water solubility and a composition for oral intake comprising the same are disclosed.
- the global dietary supplement market Due to the spread of global well-being trends and the aging of the world, the global dietary supplement market has been growing at an annual average rate of 6% for the past five years. The high growth of the dietary supplement market is expected to continue and expand further as the number of health-oriented consumers increases. In addition, the size of the health functional food market in Korea is increasing rapidly, the importance of the health functional food market is gradually increasing.
- a single functional product has been the main, but recently, the paradigm is changing, such as expanding from the center of a single functional product to a multifunctional product, or the appearance of various health functional foods.
- These dietary supplements contain many natural products obtained in nature.
- the majority of natural products have a variety of efficacy, such as a powerful antioxidant function, there is a problem that the solubility in water is very low so that the bioavailability when orally ingested.
- One embodiment of the present invention provides a composition containing a natural polyphenol compound excellent in water dispersibility or water solubility.
- Another embodiment of the present invention provides a composition for oral ingestion comprising the natural polyphenol compound-containing composition.
- a composition containing a natural polyphenol compound having water dispersibility or water solubility is provided.
- the poorly water-soluble natural polyphenol compound may be one having a solubility of 0.004 ⁇ 0.087.
- the poorly water-soluble natural polyphenol compound may include curcumin, silymarin, resveratrol, or a combination thereof.
- the saponins are tea saponin, American ginseng saponin, Panax ginseng saponin (leaf), Panax ginseng saponin (root), Soy saponin ) Or a combination thereof.
- the solubility of the poorly water-soluble natural polyphenol compound may be 0.006 ⁇ 1.087.
- the content of saponin may be 25 to 400 parts by weight based on 100 parts by weight of the poorly water-soluble natural polyphenol compound.
- composition for oral ingestion comprising the natural polyphenol compound-containing composition.
- composition for oral ingestion may be in the form of tablets, capsules, liquids or beverages, health functional foods or medicines.
- the content of the saponin in the composition for oral intake may be 0.4 to 50% by weight.
- Natural polyphenol compound-containing composition according to an embodiment of the present invention is excellent in water dispersibility or water solubility, has a high bioavailability when used in the field of oral intake composition.
- the natural polyphenol compound-containing composition according to the embodiment of the present invention includes poorly water-soluble natural polyphenolic compound (PSNPPC) and saponin, and is water dispersibility or water solubility.
- PSNPPC poorly water-soluble natural polyphenolic compound
- saponin saponin
- water dispersibility means a property in which the poorly water-soluble natural polyphenol compound-containing composition exists in an emulsion state in water
- water-soluble means that the natural polyphenol compound-containing composition is in solution state in water. It means to do.
- the poorly water-soluble natural polyphenol compound may be one having a solubility of 0.004 ⁇ 0.087.
- solubility means the amount (mg) of the solute (water-insoluble natural polyphenol compound) dissolved in 1 mL of water at 37 ° C., which is similar to human body temperature.
- the poorly water-soluble natural polyphenol compound may have a physiological function.
- the poorly water-soluble natural polyphenol compound may include curcumin, silymarin, resveratrol, or a combination thereof.
- the curcumin may be derived from turmeric root extract
- the silymarin may be derived from milk thistle (milk thistle) extract
- the resveratrol may be derived from extracts such as grapes.
- the saponins not only have physiological regulating functions such as immune enhancing function and metabolic promoting function, but also play a role of increasing water dispersibility or water solubility of the poorly water-soluble natural polyphenol compound.
- the saponins are tea saponin, American ginseng saponin, Panax ginseng saponin (leaf), Panax ginseng saponin (root), Soy saponin ) Or a combination thereof.
- the solubility of the poorly water-soluble natural polyphenol compound may be 0.006 ⁇ 1.087. If the solubility of the poorly water-soluble natural polyphenol compound is within the above range, the bioavailability of the poorly water-soluble natural polyphenol compound can be improved.
- the term "solubility of a poorly water-soluble natural polyphenol compound in dissolution of a natural polyphenol compound-containing composition” refers to the composition of the natural polyphenol compound-containing composition when the natural polyphenol compound-containing composition is added to 1 mL of water at 37 ° C. Means the amount (mg) of poorly water-soluble natural polyphenol compounds dissolved in water among the components.
- the content of saponin may be 25 to 400 parts by weight based on 100 parts by weight of the poorly water-soluble natural polyphenol compound.
- the content of the saponin is within the above range, the water dispersibility or water solubility of the poorly water-soluble natural polyphenol compound may be increased to improve its bioavailability.
- Natural polyphenol compound-containing composition according to an embodiment of the present invention having the configuration as described above can be preserved in the active ingredient as it is not physicochemically changed poorly water-soluble natural polyphenol compound when dispersed or dissolved in water, Because of the simple manufacturing method, it can be used for various purposes.
- Another embodiment of the present invention provides a composition for oral ingestion comprising the natural polyphenol compound-containing composition.
- composition for oral ingestion may be in the form of tablets, capsules, liquids or beverages, health functional foods or medicines.
- liquid means a liquid formulation that may exhibit a general liquid form or consistency, and is usually distributed in an ampule or vial form of a volume of 10 to 30 mL, and "beverage” is a general drink form. It is distributed in a 75-120 mL container.
- the tablets may be prepared by conventional manufacturing methods such as direct compression. Specifically, the tablet may be prepared by mixing the composition for oral intake homogeneously and then compressing with a tablet molding compressor.
- the capsule may be prepared by homogeneously mixing the composition for oral intake and then filling the hard capsule.
- the liquids and beverages may be prepared by injecting the composition for oral ingestion into purified water to prepare a beverage having a distinctive aroma and sweetness, and filling the resulting container into a container to make it easy to drink.
- the content of the saponin in the composition for oral intake may be 0.4 to 50% by weight.
- the content of the saponin is within the above range, it is possible to increase the bioavailability of the poorly water-soluble natural polyphenol compound, it is possible to obtain a composition for oral intake that can provide excellent physiological control activity.
- tea saponin, Western ginseng saponin, Korean ginseng foliar saponin, Korean ginseng myosaponin, and soy saponin were added in comparison with the case where other additives except Tween ® 80 were added. It was shown that the effect of increasing the solubility (ie, solubility in water) of the polyphenol compound was excellent. Tween ® 80 is effective in improving solubility but has no physiological control activity.
- Table 4 Ingredients (manufacturer, brand name) Content (mg) Resveratrol (NATUREX) 200 Korean Ginseng Approx. 400 Lactose (Sheffiled, Lactose Anhydrous 60M) 150 Starch (National Starch) 130 Colloidal Silicon Dioxide (Wacker Chemie AG, HDK N20) 10 Magnesium stearate (original wind medicine) 10 Total weight 900
- Resveratrol and Korean ginseng myosaponin were used to prepare a liquid formulation having the composition shown in Table 5 below.
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Abstract
Description
커큐민 | 실리마린 | 레스베라트롤 | |
용해도(@37℃) | 0.004 | 0.008 | 0.087 |
첨가제 | 수난용성 천연 폴리페놀 화합물(PSNPPC)의 용해도(@37℃) | |||
종류 | 첨가비율(PSNPPC:첨가제)(중량기준) | 커큐민 | 실리마린 | 레스베라트롤 |
차 사포닌 | 1:0.25 | 0.008 | 0.194 | 0.104 |
1:1 | 0.057 | 0.540 | 0.273 | |
1:4 | 0.182 | 1.087 | 0.866 | |
서양인삼 사포닌 | 1:0.25 | 0.012 | 0.168 | 0.112 |
1:1 | 0.060 | 0.347 | 0.312 | |
1:4 | 0.174 | 0.728 | 0.980 | |
고려인삼 엽사포닌 | 1:0.25 | 0.007 | 0.083 | 0.105 |
1:1 | 0.045 | 0.180 | 0.287 | |
1:4 | 0.168 | 0.435 | 1.024 | |
고려인삼 근사포닌 | 1:0.25 | 0.006 | 0.085 | 0.105 |
1:1 | 0.035 | 0.213 | 0.312 | |
1:4 | 0.127 | 0.531 | 1.020 | |
대두 사포닌 | 1:0.25 | 0.007 | 0.030 | 0.026 |
1:1 | 0.043 | 0.091 | 0.090 | |
1:4 | 0.118 | 0.325 | 0.320 | |
PEG 400 | 1:0.25 | 0.000 | 0.060 | 0.039 |
1:1 | 0.000 | 0.083 | 0.111 | |
1:4 | 0.002 | 0.124 | 0.212 | |
Tween®80 | 1:0.25 | 0.054 | 0.143 | 0.289 |
1:1 | 0.049 | 0.419 | 0.658 | |
1:4 | 0.639 | 1.436 | 1.015 | |
β-Aescin amorphors(root) | 1:0.25 | 0.000 | 0.072 | 0.005 |
1:1 | 0.000 | 0.124 | 0.194 | |
1:4 | 0.000 | 0.219 | 0.030 | |
Hawthorn Fruit P.E. | 1:0.25 | 0.000 | 0.111 | 0.062 |
1:1 | 0.001 | 0.183 | 0.076 | |
1:4 | 0.004 | 0.281 | 0.110 | |
Quillaja saponaria saponin | 1:0.25 | 0.000 | 0.054 | 0.057 |
1:1 | 0.003 | 0.136 | 0.082 | |
1:4 | 0.007 | 0.250 | 0.532 | |
Tibulus terrestris saponin | 1:0.25 | 0.000 | 0.081 | 0.068 |
1:1 | 0.002 | 0.149 | 0.087 | |
1:4 | 0.009 | 0.246 | 0.154 |
성분(제조사, 상품명) | 함량(mg) |
레스베라트롤(NATUREX) | 200 |
고려인삼 근사포닌(Hong-ziu Biotech) | 400 |
미결정셀룰로오스(FMC, Avicel PH102) | 145 |
크로스포비돈(crospovidone)(BASF, Kollidon CL) | 40 |
콜로이드성 이산화규소(HDK N20, Wacker Chemie AG) | 5 |
스테아르산 마그네슘(원풍약품) | 10 |
총 중량 | 800 |
성분(제조사, 상품명) | 함량(mg) |
레스베라트롤(NATUREX) | 200 |
고려인삼 근사포닌(Hong-ziu Biotech) | 400 |
유당(Sheffiled, Lactose Anhydrous 60M) | 150 |
전분(National Starch) | 130 |
콜로이드성 이산화규소(Wacker Chemie AG, HDK N20) | 10 |
스테아르산 마그네슘(원풍약품) | 10 |
총 중량 | 900 |
성분(제조사, 상품명) | 함량(mg) |
레스베라트롤(NATUREX) | 40 |
고려인삼 근사포닌(Hong-ziu Biotech) | 160 |
분당(Southern Home, Confectioners-sugar) | 400 |
이성화당(Fructofin, Danisco) | 400 |
스테비오사이드 50중량%(Stevian Biotechnology Corporation) | 0.23 |
레몬향(보락) | 0.05 |
정제수 | 20,000 |
총량 | 21,000.28 |
성분(제조사, 상품명) | 함량(mg) |
레스베라트롤(NATUREX) | 100 |
고려인삼 근사포닌(Hong-ziu Biotech) | 400 |
구연산(Jiali Bio Group (Qingdao) Limited) | 100 |
올리고당(신원무역상사, 이소말토올리고당) | 2 |
타우린(신원무역상사) | 500 |
정제수 | 100,000 |
총량 | 101,102 |
성분(제조사, 상품명) | 함량(mg) |
레스베라트롤(NATUREX) | 100 |
고려인삼 근사포닌(Hong-ziu Biotech) | 200 |
비타민 A(원풍약품상사) | 500 |
DL-알파 토코페롤(원풍약품상사) | 20 |
비타민 B1 질산염(원풍약품상사) | 1.5 |
비타민 2(원풍약품상사) | 1.5 |
피리독신염산염(원풍약품상사) | 2 |
비타민 B12(원풍약품상사) | 2 |
비오틴(원풍약품상사) | 0.1 |
니코틴산아미드(원풍약품상사) | 5 |
엽산(folic acid) (원풍약품상사) | 0.1 |
판토텐산칼슘(원풍약품상사) | 5 |
비타민 C(원풍약품상사) | 50 |
글리세로인삼칼슘(칼슘 함량: 4.76중량%)(원풍약품상사) | 25 |
황산철(철 함량: 5.0중량%)(원풍약품상사) | 15.45 |
황산아연(아연 함량: 1.0중량%)(원풍약품상사) | 2.74 |
황산동(동 함량: 0.5중량%)(원풍약품상사) | 1.256 |
황산망간(망간 함량: 0.58중량%)(원풍약품상사) | 1.54 |
겔화 전분(Colorcon, Starch 1500) | 46.814 |
콜로이드성 이산화규소(원풍약품상사) | 10 |
스테아르산 마그네슘(원풍약품상사) | 10 |
총량 | 1000 |
Claims (9)
- 수난용성 천연 폴리페놀 화합물; 및사포닌을 포함하고,수분산성 또는 수용해성을 갖는 천연 폴리페놀 화합물 함유 조성물.
- 제1항에 있어서,상기 수난용성 천연 폴리페놀 화합물은 0.004~0.087의 용해도를 갖는 것인 천연 폴리페놀 화합물 함유 조성물.
- 제2항에 있어서,상기 수난용성 천연 폴리페놀 화합물은 커큐민(curcumin), 실리마린(silymarin), 레스베라트롤(resveratrol) 또는 이들의 조합을 포함하는 천연 폴리페놀 화합물 함유 조성물.
- 제1항에 있어서,상기 사포닌은 차 사포닌(tea saponin), 서양인삼 사포닌(American ginseng saponin), 고려인삼 엽사포닌(Panax ginseng saponin(leaf)), 고려인삼 근사포닌(Panax ginseng saponin(root)), 대두 사포닌(Soy saponin) 또는 이들의 조합을 포함하는 천연 폴리페놀 화합물 함유 조성물.
- 제1항에 있어서,상기 천연 폴리페놀 화합물 함유 조성물의 용해시, 상기 수난용성 천연 폴리페놀 화합물의 용해도는 0.006~1.087인 천연 폴리페놀 화합물 함유 조성물.
- 제5항에 있어서,상기 사포닌의 함량은 상기 수난용성 천연 폴리페놀 화합물 100중량부에 대하여 25~400중량부인 천연 폴리페놀 화합물 함유 조성물.
- 제1항 내지 제6항 중 어느 한 항에 따른 천연 폴리페놀 화합물 함유 조성물을 포함하는 경구 섭취용 조성물.
- 제7항에 있어서,상기 경구 섭취용 조성물은 정제, 캡슐제, 액제 또는 음료의 형태로서, 건강기능식품 또는 의약품인 경구 섭취용 조성물.
- 제7항에 있어서,상기 경구 섭취용 조성물 중 상기 사포닌의 함량은 0.4~50중량%인 경구 섭취용 조성물.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13859937.8A EP2929786A4 (en) | 2012-12-05 | 2013-07-22 | COMPOSITION WITH NATURAL POLYPHENOL COMPOUNDS AND COMPOSITION FOR ORAL ADMINISTRATION THEREWITH |
JP2015546734A JP2016504310A (ja) | 2012-12-05 | 2013-07-22 | 天然ポリフェノール化合物含有組成物、及びそれを含む経口摂取用組成物 |
CN201380063748.XA CN104837366A (zh) | 2012-12-05 | 2013-07-22 | 包含天然多酚化合物的组合物以及包含该组合物的用于口服施用的组合物 |
US14/649,691 US20150342901A1 (en) | 2012-12-05 | 2013-07-22 | Composition comprising natural polyphenol compounds, and composition for oral administration comprising same |
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KR1020120140548A KR20140073659A (ko) | 2012-12-05 | 2012-12-05 | 천연 폴리페놀 화합물 함유 조성물 및 이를 포함하는 경구 섭취용 조성물 |
KR10-2012-0140548 | 2012-12-05 |
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WO2014088182A1 true WO2014088182A1 (ko) | 2014-06-12 |
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PCT/KR2013/006523 WO2014088182A1 (ko) | 2012-12-05 | 2013-07-22 | 천연 폴리페놀 화합물 함유 조성물 및 이를 포함하는 경구 섭취용 조성물 |
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US (1) | US20150342901A1 (ko) |
EP (1) | EP2929786A4 (ko) |
JP (1) | JP2016504310A (ko) |
KR (1) | KR20140073659A (ko) |
CN (1) | CN104837366A (ko) |
WO (1) | WO2014088182A1 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105595335A (zh) * | 2016-01-04 | 2016-05-25 | 环翠楼红参生物科技股份有限公司 | 一种高丽红参玛咖细胞破壁超微粉的制备方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2018197385A1 (en) * | 2017-04-25 | 2018-11-01 | Evolva Sa | Nature-identical supplements to improve the productivity of animals |
JP7290011B2 (ja) * | 2017-10-05 | 2023-06-13 | ペトロユーロアジア株式会社 | ルテオリン含有組成物およびその製造方法 |
KR20210041595A (ko) * | 2018-08-06 | 2021-04-15 | 나투렉스 에스아 | 커큐미노이드 조성물 |
CN115297832A (zh) * | 2019-12-31 | 2022-11-04 | 莱雅公司 | 包含酚类化合物和助水溶物的组合物 |
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- 2013-07-22 JP JP2015546734A patent/JP2016504310A/ja active Pending
- 2013-07-22 CN CN201380063748.XA patent/CN104837366A/zh active Pending
- 2013-07-22 WO PCT/KR2013/006523 patent/WO2014088182A1/ko active Application Filing
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Also Published As
Publication number | Publication date |
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US20150342901A1 (en) | 2015-12-03 |
EP2929786A1 (en) | 2015-10-14 |
CN104837366A (zh) | 2015-08-12 |
JP2016504310A (ja) | 2016-02-12 |
KR20140073659A (ko) | 2014-06-17 |
EP2929786A4 (en) | 2016-07-27 |
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