WO2014077300A1 - Composition de liquide antibactérien - Google Patents

Composition de liquide antibactérien Download PDF

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Publication number
WO2014077300A1
WO2014077300A1 PCT/JP2013/080744 JP2013080744W WO2014077300A1 WO 2014077300 A1 WO2014077300 A1 WO 2014077300A1 JP 2013080744 W JP2013080744 W JP 2013080744W WO 2014077300 A1 WO2014077300 A1 WO 2014077300A1
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Prior art keywords
antibacterial
liquid composition
antibacterial liquid
fatty acid
water
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PCT/JP2013/080744
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English (en)
Japanese (ja)
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博朗 飯田
雅友 水野
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イーダ株式会社
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Priority to CN201380059127.4A priority Critical patent/CN104902758A/zh
Publication of WO2014077300A1 publication Critical patent/WO2014077300A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A01N59/20—Copper
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/17—Combination with washing or cleaning means

Definitions

  • the present invention relates to an antibacterial liquid composition having an antibacterial action against bacteria and viruses.
  • antibacterial agent is used in various fields for the purpose of preventing contamination and rot by microorganisms, and preventing and treating infection by bacteria or viruses.
  • antibacterial components include concentrated hydrochloric acids, alcohols, phenols, halogens, formaldehyde, glutaraldehyde, higher fatty acids, lower fatty acids, lactones, (amphoteric or anionic) surfactants, silver and copper
  • compounds such as ozone / hydrogen peroxide, peracetic acid, sodium hypochlorite and the like.
  • the Food Sanitation Law stipulates antibacterial components that can be used for cleaning, antibacterial, and sterilization of food in the food service industry and food factories.
  • antibacterial components include sodium hypochlorite, organic acids such as acetic acid, lactic acid, citric acid and fumaric acid, metal ions having antibacterial activity such as zinc, copper, iron and silver, and polyhydric alcohols.
  • nonionic surfactants such as sorbitan fatty acid esters and glycerin fatty acid esters are recognized.
  • sodium hypochlorite has disadvantages such as practical safety (careful not to mix with acid, etc.), loss of sterilization effect due to the presence of organic substances, strong odor, etc. Some may not be usable. Some organic acids have a strong odor similar to sodium hypochlorite.
  • an antibacterial agent composition containing a polyhydric alcohol antibacterial agent and a silver antibacterial agent has been proposed from the viewpoints of safety, prevention of sterilization effect loss, odor suppression, and the like (for example, Patent Documents). 1).
  • Patent Document 1 an antibacterial agent composition containing a polyhydric alcohol antibacterial agent and a silver antibacterial agent has been proposed from the viewpoints of safety, prevention of sterilization effect loss, odor suppression, and the like.
  • Patent Document 1 there are certainly no inconveniences such as attention to practical safety, loss of sterilization effect, strong odor, etc., but the antibacterial activity is sodium hypochlorite, etc.
  • the antibacterial effect may be insufficient depending on the type and amount of bacteria.
  • an antibacterial liquid composition comprising a metal ion having an antibacterial action and a surfactant that forms the metal ion and a metal salt insoluble in water.
  • Patent Document 2 As described in this specification, the antibacterial liquid composition described in Patent Document 2 uses only ingredients recognized as food additives, and is water-insoluble formed by these ingredients. Since the metal salt has a high antibacterial activity, it has both high safety and effective antibacterial properties against a wide range of microorganisms.
  • the present invention has been made in view of the above circumstances, and in an antibacterial liquid composition that combines high safety and excellent antibacterial properties, by further increasing the dispersibility of antibacterial components, it is more stable and excellent.
  • the purpose is to be able to exert antibacterial effects.
  • the present inventors have used a water-insoluble metal salt produced by a reaction between a metal ion having antibacterial properties and a surfactant as an antibacterial component,
  • a specific type of dispersant as a dispersant and further using alcohol as a dispersion aid to improve dispersibility
  • the antibacterial component has high dispersibility in antibacterial compositions having both high safety and excellent antibacterial properties. Based on this finding, the present invention has been completed.
  • the present invention relates to a water-insoluble metal salt produced by a reaction between a metal ion having antibacterial properties and a surfactant, polyglycerin fatty acid ester, polyoxyethylene (hardened) castor oil, and polyoxyethylene polyoxypropylene glycol.
  • An antibacterial agent containing at least one dispersant selected from the group consisting of alcohol and an alcohol content of 3% by mass to 80% by mass based on the mass of the entire composition. It is a liquid composition.
  • the metal ions having antibacterial properties are preferably one or more ions selected from the group consisting of aluminum ions, zinc ions, copper ions, iron ions and silver ions.
  • the metal ions having antibacterial properties are aluminum ions.
  • the said surfactant is 1 type, or 2 or more types of nonionic surfactant selected from the group which consists of glycerol fatty acid ester, sorbitan fatty acid ester, and sucrose fatty acid ester.
  • the quantity of the said surfactant with respect to the said aluminum ion is 0.4 or more and 15 or less by mass ratio.
  • the said dispersing agent is polyglyceryl fatty acid ester.
  • content of the said dispersing agent is 0.001 mass% or more and 0.3 mass% or less on the basis of the mass of all the compositions.
  • the alcohol is preferably a lower alcohol having 3 or less carbon atoms.
  • an antibacterial liquid composition having both high safety and excellent antibacterial properties, it is possible to more stably exhibit an excellent antibacterial effect by further increasing the dispersibility of the antibacterial component. .
  • the antibacterial liquid composition according to the present invention will be described in the following order. DESCRIPTION OF SYMBOLS 1 Composition of antibacterial liquid composition 2 Manufacturing method of antibacterial liquid composition 3 Principle of antibacterial action 4 Use of antibacterial liquid composition 5 Usage of antibacterial liquid composition
  • the antibacterial liquid composition according to the present invention includes a water-insoluble metal salt produced by a reaction between an antibacterial metal ion and a surfactant, It mainly contains at least one dispersant selected from the group consisting of glycerin fatty acid ester, polyoxyethylene (cured) castor oil, and polyoxyethylene polyoxypropylene glycol, and a dispersion medium.
  • the antibacterial liquid composition is a dispersion aqueous solution (colloidal solution) in which a water-insoluble metal salt is uniformly dispersed in a dispersion medium by a dispersant such as polyglycerin fatty acid ester.
  • a dispersant such as polyglycerin fatty acid ester.
  • the water-insoluble metal salt is a water-insoluble metal salt formed by a reaction between a metal ion having antibacterial properties and a surfactant.
  • the surfactant is a fatty acid derivative.
  • a metal soap containing a metal having antibacterial properties is obtained.
  • This water-insoluble metal salt has a role as an antibacterial component in the present antibacterial liquid composition.
  • the antibacterial activity of the aqueous dispersion containing the water-insoluble metal salt, that is, the antibacterial liquid composition is higher than that of the aqueous solution containing a metal ion having antibacterial properties.
  • the antibacterial liquid composition is usually not preferred in the field of antibacterial agents and cleaning agents, as described in, for example, JP-A-7-29297 and JP-A-2008-214621.
  • the salted-out product that is, the production of water-insoluble metal salt and the production conditions thereof are actively utilized.
  • metal ions generate metal soap (water-insoluble metal salt) and cause a reduction in surface activity, so that the use of metal soap has been avoided until now.
  • a dispersion solution of a water-insoluble metal salt having an antibacterial activity higher than that of a metal ion having a conventional antibacterial property (the present antibacterial liquid) Composition).
  • the water-insoluble metal salt according to the present invention is hardly decomposed by an acid or alkali, the quality of the antibacterial liquid composition in which the metal salt is dispersed in a solvent is stable for a long time.
  • the present antibacterial liquid composition is used for food, tableware, and the like due to the antibacterial activity of the water-insoluble metal salt to which the metal ions having antibacterial properties are bound. It is possible to inactivate bacteria, viruses and the like attached to food production apparatuses and skin.
  • examples of metal ions having antibacterial properties used in the present antibacterial liquid composition include aluminum (Al) ions, zinc (Zn) ions, copper (Cu) ions, iron (Fe) ions, and silver (Ag). Ions can be used. Since these ion sulfates and other inorganic acid salts (for example, zinc sulfate, alum, etc.), gluconates and other organic acid salts are recognized as food additives, the antibacterial liquid composition is used as a food. When used as an antibacterial agent against the above, it is preferable to use the above metal ions. Further, Al ions are particularly preferable as the metal ions having antibacterial properties according to the present invention.
  • the surfactant used in the antibacterial liquid composition is not particularly limited as long as it can generate a water-insoluble metal salt by reacting with the metal ions having antibacterial properties. Any of a surfactant, an amphoteric surfactant, and a nonionic surfactant may be used.
  • the anionic surfactant used in the antibacterial liquid composition is not particularly limited, and examples thereof include alkyl sulfates, polyoxyethylene alkyl ether sulfates, sulfosuccinates, N-acyl amino acid salts, carboxylates, Examples thereof include sulfonates.
  • the cationic surfactant used in the antibacterial liquid composition is not particularly limited, and examples thereof include alkyl ammonium salts and quaternary ammonium salts.
  • amphoteric surfactant used in the antibacterial liquid composition is not particularly limited, and examples thereof include alkyl (amido) betaine and alkyldimethylamine oxide.
  • the nonionic surfactant used in the antibacterial liquid composition is not particularly limited.
  • glycerin fatty acid ester sorbitan fatty acid ester, sucrose fatty acid ester, polyoxyalkylene lauryl ether (for example, polyoxyethylene lauryl ether) ), Polyoxyethylene oleyl cetyl ether, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, alkyl alkanolamide, alkyl polyglucoxide and the like.
  • the antibacterial liquid composition when used for food cleaning, antibacterial and the like, from the viewpoint of safety to the human body, it is a nonionic surfactant that is recognized as a food additive as a surfactant. It is preferable to use an agent.
  • nonionic surfactants include glycerin fatty acid esters (monoesters, diesters, and triesters), polyhydric alcohols such as sorbitan fatty acid esters, sucrose fatty acid esters, sugar alcohols, and sugars. Examples include esters with fatty acids. These fatty acid esters may be used alone or in combination of two or more.
  • sucrose fatty acid ester has solubilization power with respect to water rather than glycerol fatty acid ester and sorbitan fatty acid ester, the water-insoluble metal salt produced
  • the content of the surfactant in the antibacterial liquid composition is preferably 0.4 or more and 15 or less, and more preferably 1.5 or more and 11 or less, in terms of mass ratio with respect to metal ions having antibacterial properties. More preferably, it is 2 or more and 11 or less.
  • the surfactant content is within this range, aggregation of water-insoluble metal salt particles in the antibacterial liquid composition can be suppressed, and as a result, dispersibility of the water-insoluble metal salt can be improved. . Therefore, it can suppress that this antibacterial liquid composition becomes cloudy, or the aggregation particle
  • the dispersant has a role of uniformly dispersing the above-described water-insoluble metal salt containing metal ions having antibacterial properties in a dispersion medium described later.
  • a dispersant examples include polyglycerin fatty acid ester, polyoxyethylene (cured) castor oil, and polyoxyethylene polyoxypropylene glycol. These dispersants may be used alone. You may use combining more than a seed.
  • the dispersant used in the antibacterial liquid composition it is particularly preferable to use a polyglycerol fatty acid ester.
  • polyglycerin fatty acid ester is recognized as a food additive
  • glycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester and the like that are recognized as food additives as a surfactant
  • an antibacterial component Both the water-insoluble metal salt
  • the dispersant polyglycerin fatty acid ester
  • the polyglycerin fatty acid ester is generally a fatty acid esterified to one or more hydroxy groups of polyglycerin obtained by dehydrating condensation polymerization of glycerin, and is hydrophilic depending on the degree of polymerization and the number and type of fatty acids. Various types are available, such as sexual and hydrophobic.
  • the polyglycerol fatty acid ester used in the present antibacterial liquid composition those capable of satisfactorily dispersing the above-mentioned water-insoluble metal salt are preferable.
  • Such a polyglycerin fatty acid ester is not particularly limited, but preferably has a degree of polymerization of 8 or more and 12 or less and an acid value of 5 or less.
  • Examples of the fatty acid used for the synthesis of the polyglycerol fatty acid ester used in the antibacterial liquid composition include caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, and oleic acid. It is done. These fatty acids may be used individually by 1 type, and may be used in combination of 2 or more type.
  • the content of the dispersant in the antibacterial liquid composition is preferably 0.001% by mass or more and 0.3% by mass or less, and 0.005% by mass or more based on the mass of the entire composition.
  • the content is more preferably 0.2% by mass or less, and still more preferably 0.01% by mass or more and 0.1% by mass or less.
  • the content of the dispersant is within this range, aggregation of water-insoluble metal salt particles in the antibacterial liquid composition can be suppressed, and as a result, dispersibility of the water-insoluble metal salt can be enhanced. Therefore, it can suppress that this antibacterial liquid composition becomes cloudy, or the aggregation particle
  • the content of the dispersant is too small, the effect of dispersing the water-insoluble metal salt may not be sufficiently exhibited. Conversely, if the content is too large, the antibacterial activity of the antibacterial liquid composition may be reduced.
  • the antibacterial liquid composition mainly contains alcohol and water as a dispersion medium in which the above-described water-insoluble metal salt is dispersed.
  • alcohol a dispersion medium in which the above-described water-insoluble metal salt is dispersed.
  • Alcohol has a role as a dispersing agent together with water, a role as a dispersion aid for improving the dispersibility of the water-insoluble metal salt, and a role as an antibacterial or sterilizing component.
  • alcohol is an essential component in order to disperse the water-insoluble metal salt particles uniformly without agglomeration.
  • the alcohol used in the antibacterial liquid composition it is preferable to use a lower alcohol having 3 or less carbon atoms.
  • a lower alcohol By using such a lower alcohol, the dispersibility of the water-insoluble metal salt can be improved to increase the transparency of the antibacterial liquid composition, and the antibacterial or sterilizing effect against bacteria and viruses can be increased.
  • a higher alcohol having 4 or more carbon atoms when a higher alcohol having 4 or more carbon atoms is used, it becomes difficult to handle because it becomes difficult to dissolve in water and the viscosity increases.
  • Examples of the lower alcohol described above include methanol, ethanol, 1-propanol, 2-propanol, etc. Of these, ethanol is particularly used from the viewpoint of enhancing safety and antibacterial / sterilizing effects. It is preferable.
  • the content of alcohol in the antibacterial liquid composition is preferably 3% by mass or more and 80% by mass or less, and more preferably 20% by mass or more and 70% by mass or less, based on the mass of the entire composition. Preferably, it is 40 mass% or more and 60 mass% or less.
  • the alcohol content is within this range, aggregation of water-insoluble metal salt particles in the antibacterial liquid composition can be suppressed, and as a result, dispersibility of the water-insoluble metal salt can be enhanced. Therefore, it can suppress that this antibacterial liquid composition becomes cloudy, or the aggregation particle
  • the antibacterial power of this antibacterial liquid composition can be improved more as content of alcohol is the said range.
  • water has a role as a dispersion medium for dispersing the above-described water-insoluble metal salt.
  • water used in the antibacterial liquid composition it is preferable to use ion-exchanged water or distilled water.
  • these metal ions generate salts with the above-described surfactants, dispersants, and the like.
  • the antibacterial property and liquid stability maintaining a state in which no precipitate is generated or cloudiness is generated
  • the content of water in the antibacterial liquid composition is not particularly limited, and from the viewpoint of achieving both high dispersibility of the water-insoluble metal salt and high antibacterial activity as a whole composition, the balance of other necessary components Should be water.
  • the antibacterial liquid composition mainly comprises a water-insoluble metal salt produced by an antibacterial metal ion and a surfactant, a polyglycerin fatty acid ester, an alcohol, and water.
  • a surfactant e.g., sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium bicarbonate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium sulfate, sodium
  • the antibacterial liquid composition may further contain a pH adjuster.
  • the pH adjuster is used to make the antibacterial liquid composition weakly acidic to neutral.
  • the dispersion stability of the water-insoluble metal salt described above can be improved.
  • the pH of the antibacterial liquid composition is preferably in the range of 3 to 7, more preferably in the range of 3 to 5.
  • Examples of the pH adjuster used in the antibacterial liquid composition include sodium lactate, sodium citrate, sodium lactate, potassium tartrate, sodium tartrate, sodium malate, sodium fumarate, and sodium succinate. , Other organic acid salts, arginine, sodium carbonate and the like, and those that lower the pH, such as lactic acid, citric acid, phosphoric acid, acetic acid, tartaric acid, malic acid, fumaric acid, adipic acid, other organic acids, glycine, etc. Is mentioned. What is necessary is just to select suitably the kind of pH adjuster used for this antibacterial liquid composition so that the role of the other component contained in this antibacterial liquid composition may not be inhibited.
  • the content of the pH adjusting agent in the antibacterial liquid composition is not particularly limited, and the composition as a whole is weakly acidic to neutral depending on the type of components contained in the antibacterial liquid composition. An amount that falls within the range may be used.
  • the antibacterial liquid composition may further contain various additives as long as the effects of the present invention described above are not impaired.
  • additives include fragrances, essential oils, viscosity modifiers, foam modifiers, enzymes (for degrading proteins, lipids, carbohydrates, etc.), saccharides (sorbitol, xylitol, trehalose, etc.), amino acids, etc. Is mentioned.
  • fragrances and essential oils include geraniol, citronellol, eugenol, linalool, terpineol, thymol, menthol, limonene, and perillaaldehyde that are recognized as food additives.
  • the antibacterial liquid composition mainly includes an inorganic acid salt of a metal that is a source of metal ions having antibacterial properties, a surfactant, a dispersant such as a polyglycerin fatty acid ester, and an alcohol. It can be obtained by mixing with water and adjusting the pH.
  • the antibacterial liquid composition can be prepared, for example, as follows.
  • the above-described metal salt containing metal ions having antibacterial properties is dissolved in water (preferably ion-exchanged water).
  • water preferably ion-exchanged water
  • zinc sulfate, alum (potassium aluminum sulfate, AlK (SO 4 ) 2 ⁇ 12H 2 O), copper gluconate, or the like can be used as the metal salt.
  • the above-mentioned surfactant, a dispersant such as polyglycerin fatty acid ester, and alcohol are added to the obtained aqueous solution, and after stirring and mixing, water is further added as necessary.
  • the antibacterial liquid composition which is a colloidal dispersion in which a water-insoluble metal salt is dispersed in water, can be obtained by using the pH adjuster described above to adjust the liquidity to an acidic to neutral range. it can.
  • this antibacterial liquid composition when manufacturing this antibacterial liquid composition, by adding a dispersant such as polyglycerin fatty acid ester and alcohol, the aggregation of the water-insoluble metal salt in the antibacterial liquid composition is suppressed. In addition, the dispersibility of the water-insoluble metal salt can be significantly improved.
  • the antibacterial component in the antibacterial liquid composition that is, the above-mentioned water-insoluble metal salt is diluted with water or alcohol
  • a metal ion as a hydrophilic component and a surfactant as a lipophilic component Glycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, etc.
  • a metal ion as a hydrophilic component and a surfactant as a lipophilic component Glycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, etc.
  • metal ions and surfactants form water-insoluble metal salts, which are polyglycerin fatty acid esters, etc.
  • a water-insoluble metal salt adheres to the surface membrane of a living body such as bacteria or virus.
  • the water-insoluble metal salt adhering to the surface membrane of the living body penetrates into the living body such as bacteria and viruses.
  • the water-insoluble metal salt that has penetrated into the living body causes protein denaturation and coagulation in the living body of bacteria, viruses, etc., and denaturates virus particle antigens and bacterial glycoproteins in a low concentration and in a short time. Is inactivated.
  • the antibacterial liquid composition can inactivate bacteria, viruses, and the like attached to the object.
  • the application of the antibacterial liquid composition as described above is not particularly limited as long as it is an application that requires antibacterial / disinfecting / bacteriostatic or the like against bacteria, viruses, etc.
  • This antibacterial liquid for uses such as antibacterial (bacterial and bacteriostatic) agents used in kitchen supplies, food production equipment, skin and other objects, bacteriostatic and bacteriostatic agents, food quality preservation agents, and cleaning agents Compositions can be used.
  • This antibacterial liquid composition can be undiluted or diluted and sprayed or applied to an object (food, tableware, kitchen utensils, food cleaning devices, skin, etc.), or the object can be applied to the composition. It can be used by a method such as dipping. Moreover, it does not specifically limit about methods, such as spraying, application
  • Example preparation method A sample of the antibacterial liquid composition used in this evaluation was prepared as follows. First, as described in Table 1 and Table 2 below, zinc sulfate or alum is dissolved in ion-exchanged water as a metal ion source having antibacterial properties, and the obtained aqueous solution is described in Table 1 and Table 2.
  • Nonionic surfactant glycerin fatty acid ester, sorbitan fatty acid ester, any one or two of sucrose fatty acid ester
  • polyglycerin fatty acid ester or polyoxyethylene sorbitan fatty acid ester as a dispersant, and alcohol are added, After stirring and mixing, ion-exchanged water was further added so that water was contained in the composition in the amounts shown in Tables 1 and 2.
  • a pH adjusting agent the pH was adjusted to 5.5 to 6.0 using a combination of citric acid and arginine or sodium lactate, and Examples 1 to 21 (see Table 1) and Comparative Examples 1 to 17 ( Samples for evaluation of dispersibility as shown in Table 2 were obtained.
  • the surfactants and dispersants used in the examples and comparative examples are as follows.
  • Glycerin fatty acid ester Glycerin monocaprylate
  • Sorbitan fatty acid ester Sorbitan octate
  • Sucrose fatty acid ester Sucrose monolaurate
  • Polyglycerol fatty acid ester Glycerin monolaurate
  • Polyoxyethylene (hardened) castor oil PEG40 Hydrogenated castor oil
  • Polyoxy Ethylene polyoxypropylene glycol Polyoxyethylene polyoxypropylene glycol (molecular weight 2000, EO content 20%)
  • Polyoxyethylene sorbitan fatty acid ester polyoxyethylene (20) sorbitan oleate (polysorbate 80)
  • ⁇ Appearance evaluation method> The dispersibility of the prepared sample was determined by visually observing the appearance of the sample immediately after preparation and after being left at 50 ° C. for 1 week, and evaluated according to the following criteria. did.
  • the results of Examples 1 to 21 are shown in Table 1, and the results of Comparative Examples 1 to 17 are shown in Table 2.
  • Dispersibility of water-insoluble metal salt is good by using at least one of polyoxyethylene sorbitan fatty acid ester, polyoxyethylene (hardened) castor oil and polyoxyethylene polyoxypropylene glycol and containing alcohol. It was shown that a colorless and transparent liquid was obtained.
  • the antibacterial property was evaluated by the following method for the following bacteria and viruses.
  • (C) A test tube containing 100 ⁇ L of the bacterial suspension so that the number of bacteria in the test product is about 1.5 ⁇ 10 6 cells / mL, and containing the test product of (a) and a control sterilized physiological saline. After 10 minutes and 20 minutes, 100 ⁇ L and 10 ⁇ L were sampled, inoculated into SCDLP agar plate medium, and observed by streak culture at 35 ° C. for 72 hours ( Campylobacter was observed on Brucella HK agar at 37 ° C. for 72 hours). The test article temperature during the test was 25 ° C., the room temperature was 25.5 ° C., and the humidity was 49%.
  • (C) A test tube containing 100 ⁇ L of the bacterial suspension so that the number of bacteria in the test product is about 1.5 ⁇ 10 6 cells / mL, and containing the test product of (a) and a control sterilized physiological saline. After 10 minutes, 100 ⁇ L each was sampled, inoculated into a SCDLP agar plate medium, and observed by streak culture at 35 ° C. for 72 hours (Legionella was CYE agar medium). Was observed for 120 hours at 35 ° C. Welsh bacteria were observed on Brucella HK agar medium at 35 ° C. for 72 hours). The test article temperature during the test was 25 ° C., the room temperature was 25 ° C., and the humidity was 49%.
  • Influenza virus type A
  • a virus solution purified by density gradient centrifugation is used as a test virus solution .
  • B 900 ⁇ L of test solution and 100 ⁇ L of 2.3 ⁇ 10 9 TCID 50 / mL test virus solution were added to the test tube, gently mixed with a vortex mixer, and allowed to act at room temperature for a predetermined time. Thereafter, 100 ⁇ L was immediately collected and diluted 100-fold with 9.9 mL of cell maintenance medium (DMEM) containing 0.2% fetal bovine serum (FBS).
  • DMEM cell maintenance medium
  • FBS fetal bovine serum
  • This solution was used as a sample stock solution for a virus inactivation effect test to evaluate the virus inactivation effect.
  • PBS phosphate buffered saline
  • ethanol for disinfection of Japanese Pharmacopoeia was used instead of the test solution.
  • Feline calicivirus (norovirus substitute))
  • CPE feline kidney-derived cells
  • Example 3 As shown in Table 3, the antibacterial liquid composition of Example 1 had an inactivating effect against any of the bacteria and viruses evaluated above.
  • Examples 2 to 21 the same antibacterial / antiviral test as in Example 1 was performed, and in each example, the same results as in Example 1 were obtained.

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Abstract

L'invention concerne une composition de liquide antibactérien qui combine une stabilité élevée et d'excellentes propriétés antibactériennes, et qui permet de développer des effets antibactériens excellents et stables par augmentation des propriétés de dispersion d'un composant antibactérien. Afin de combiner une stabilité élevée et d'excellentes propriétés antibactériennes, et d'augmenter les propriétés de dispersion de son composant antibactérien, la composition de l'invention comprend, en tant que composant : un sel métallique insoluble dans l'eau produit par réaction d'ions métalliques possédant des propriétés antibactériennes et d'un tensio-actif ; au moins une sorte d'agent de dispersion choisie dans un groupe constitué d'un ester d'acide gras de polyglycéryle, d'une huile de ricin de polyoxyéthylène (durci) et d'un polyoxyéthylène polyoxypropylène glycol ; et un alcool.
PCT/JP2013/080744 2012-11-15 2013-11-14 Composition de liquide antibactérien WO2014077300A1 (fr)

Priority Applications (1)

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CN201380059127.4A CN104902758A (zh) 2012-11-15 2013-11-14 抗菌性液体组合物

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JP7402938B1 (ja) 2022-07-27 2023-12-21 株式会社タイショーテクノス 非繊維製品用抗ウイルス加工剤

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JP6984122B2 (ja) 2016-12-15 2021-12-17 東洋製罐グループホールディングス株式会社 抗ウイルス性を有する分散液
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JP2019026592A (ja) * 2017-07-28 2019-02-21 イーダ株式会社 アルコール系消毒剤
JP2019026603A (ja) * 2017-08-01 2019-02-21 ライオン株式会社 忌避剤組成物
CN111107747A (zh) * 2018-08-29 2020-05-05 株式会社日吉 对于军团菌属菌的消毒剂、水处理方法、浴槽水用添加剂和空调冷却塔水用添加剂
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JP7402938B1 (ja) 2022-07-27 2023-12-21 株式会社タイショーテクノス 非繊維製品用抗ウイルス加工剤

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