WO2014015705A1 - Gaze hémostatique soluble et procédé de préparation associé - Google Patents

Gaze hémostatique soluble et procédé de préparation associé Download PDF

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Publication number
WO2014015705A1
WO2014015705A1 PCT/CN2013/075728 CN2013075728W WO2014015705A1 WO 2014015705 A1 WO2014015705 A1 WO 2014015705A1 CN 2013075728 W CN2013075728 W CN 2013075728W WO 2014015705 A1 WO2014015705 A1 WO 2014015705A1
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Prior art keywords
solvent
solution
cellulose fiber
spun cellulose
weight
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PCT/CN2013/075728
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English (en)
Chinese (zh)
Inventor
吕秋兰
王晓东
陶炳志
Original Assignee
佛山市优特医疗科技有限公司
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Publication of WO2014015705A1 publication Critical patent/WO2014015705A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
    • D06M11/32—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond
    • D06M11/36—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond with oxides, hydroxides or mixed oxides; with salts derived from anions with an amphoteric element-oxygen bond
    • D06M11/38—Oxides or hydroxides of elements of Groups 1 or 11 of the Periodic Table
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
    • D06M13/184—Carboxylic acids; Anhydrides, halides or salts thereof
    • D06M13/207—Substituted carboxylic acids, e.g. by hydroxy or keto groups; Anhydrides, halides or salts thereof
    • D06M13/21—Halogenated carboxylic acids; Anhydrides, halides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Definitions

  • the invention relates to a soluble hemostatic gauze and a preparation method thereof, in particular to a soluble hemostatic gauze prepared by carboxymethylated solvent-spun cellulose fibers and a preparation method thereof.
  • hemostatic materials including fibrin glue, collagen, chitosan, carboxymethyl cellulose (soluble hemostatic gauze).
  • the ideal biological hemostatic material should have the following characteristics: rapid hemostasis, no toxicity, no antigenicity, no increase in the probability of infection, no effect on tissue healing, and low price.
  • Soluble hemostatic gauze has a strong affinity for water and salt water. When it meets blood, it can quickly absorb the moisture in the blood and dissolve. The formed colloid blocks the end of the capillary, promotes blood concentration, increases viscosity, and slows blood flow. To achieve the purpose of hemostasis. Because of its good tissue compatibility, it is soft and light, easy to pack, apply, plug and other operations, can be absorbed in the body, and is now widely used in surgical wound bleeding and bleeding is not easy to stop.
  • Soluble hemostatic gauze currently used clinically includes carboxymethyl cellulose, calcium alginate dressing, gentamicin sulfate soluble hemostatic gauze and baht.
  • CN101491688A discloses a "soluble hemostatic gauze and a preparation method thereof", which uses a material of a skim gauze;
  • CN1109708C discloses a "method for preparing a soluble anti-adhesion material from a cellulosic material and a product thereof", which adopts the natural nature of cotton, hemp and silk. The fiber is used as a raw material to obtain a soluble anti-blocking material by carboxymethylation.
  • the above-mentioned patents have low fiber crystallinity and low strength, and the resulting soluble hemostatic gauze absorbs water and is sticky, and is easy to curl.
  • the present invention provides a soluble hemostatic gauze characterized in that the soluble hemostatic gauze is made of carboxymethylated solvent-spun cellulose fibers.
  • carboxymethylated solvent-spun cellulosic fiber has a linear density of from 1 to 5 dtex, preferably from 1.5 to 3 dtexo.
  • the carboxymethylated solvent-spun cellulosic fibers have a length of 10-125 mm.
  • the soluble hemostatic gauze is obtained by carboxymethylating a solvent-spun cellulose fiber, followed by weaving.
  • the present invention relates to a method of preparing the soluble hemostatic gauze, characterized in that the method comprises:
  • the solvent-spun cellulose fiber is broken by mechanical force in 50 ° C hot water for 5-60 min, preferably 5 min;
  • the sodium chloroacetate is 1:10 ⁇ 100, v/v, and the carboxymethylated alkalized solvent-spun cellulose fiber is obtained.
  • the concentration of the sodium chloroacetate solution in ethanol is 18- of the total weight of the ethanol solution. 40% by weight, preferably 30.6% by weight;
  • the invention also relates to a method of preparing the soluble hemostatic gauze, characterized in that The method includes:
  • the solvent-spun cellulose fiber is broken by mechanical force in 50 ° C hot water for 5-60 min, preferably 5 min;
  • the alkalized solvent-spun cellulose fiber, the mixed solution is a solution of sodium hydroxide, water, sodium chloroacetate and ethanol, wherein the mass ratio of sodium hydroxide: sodium chloroacetate is 3:1-1:3,
  • the ethanol content is 20-70% by weight based on the total weight of the solution, and the water content is 50-80% by weight based on the total weight of the solution;
  • the water-ethanol solution of acetic acid comprises 2.5% by weight of acetic acid, 42.5% by weight of water and 55% by weight of ethanol, based on the total weight of the solution, and the aqueous-ethanol solution of the acetic acid is alkalized with the carboxymethylation.
  • the mass ratio of the solvent-spun cellulose fiber is 5:50;
  • the soluble hemostatic gauze of the invention is changed into solvent-spun cellulose fiber as raw material, and the crystallinity thereof is higher than other cellulose fibers, and the carboxymethyl cellulose obtained by carboxymethylation absorbs water to form a glue but is not sticky, transparent and not rolled. side.
  • a typical representative product of solvent-spun cellulosic fibers is Lyocdl (Lexell) under the trade name Tencel, and its production method is disclosed in European Patent No. EP0616650 and U.S. Patent No. 5,731,083.
  • Another representative product is the Lyocdl filament produced by Hyosung Corporation of Korea.
  • Solvent-spun cellulose fibers have a compact structure, high crystallinity, and high fiber strength, especially the fiber wet strength is generally higher than ordinary viscose fibers.
  • the present invention utilizes carboxymethylated solvent-spun cellulosic fibers to prepare soluble hemostatic gauze.
  • the carboxymethylated solvent-spun cellulose fibers have a linear density of from 1 to 5 dtex, preferably from 1.5 to 3 dtex; and a length of from 10 to 125 mm.
  • Cellulose is a polymer based on glucose and has a molecular formula of (C 6 H 1Q 0 5 ) n .
  • the primary and secondary hydroxyl groups in the cellulose macromolecular ring have different reaction abilities. Under alkaline conditions, the secondary hydroxyl group has good reactivity and can be etherified with sodium chloroacetate.
  • the main processes of the reaction are as follows: :
  • Various mechanical processing processes can greatly alter the physical and chemical properties of cellulose fibers due to mechanical stress and increase the rate of cellulose in various chemical reactions.
  • Common physical pretreatment methods include high energy electron radiation, ionizing radiation, microwave and ultrasonic treatment. They loosen the structure of the cellulose and affect the crystal structure of the cellulose, thereby increasing the activity of the cellulose and increasing the accessibility.
  • the pretreatment method of the present invention is to disperse the solvent-spun cellulose fiber by mechanical force in hot water at 50 ° C, and the pretreatment time is 5 to 60 min, preferably 5 min.
  • the carboxymethylated cellulose fibers are prepared by stepwise alkalization and etherification: the cellulose fibers are first alkalized to alkalized cellulose fibers and then etherified to a carboxymethyl group.
  • Cellulose fiber This preparation process is a reaction in which a base is consumed and sodium chloride is formed, and therefore, the molar ratio of sodium hydroxide to sodium chloroacetate is usually controlled to be slightly larger than 2.
  • Fiber The ratio of the amount of the washing liquid to the mass of the fiber is 5 to 125 times. It has been found that the swelling treatment of sodium hydroxide solution is one of the most effective means of treating cellulose, and the cellulose accessibility after alkali swelling is improved.
  • the cellulose fiber is alkalized using a sodium hydroxide aqueous solution at a concentration of 10 to 45% by weight, preferably 18% by weight (based on the total weight of the aqueous solution), and the alkalization temperature is performed. It is 20-70 ° C, preferably 50 ° C; the time for alkalization is 30 to 60 min, preferably 30 min.
  • the alkalized cellulose fibers are subjected to etherification reaction in an ethanol solution of sodium chloroacetate, and the concentration of the sodium chloroacetate solution in ethanol is 18 to 40% by weight, preferably 30.6% by weight, based on the total weight of the solution.
  • the etherification reaction is a neutralization of a base and a substitution reaction of an alkalized cellulose fiber.
  • the higher the etherification temperature the faster the reaction rate and the shorter the reaction time, but the side reaction is also accelerated. From the standpoint of chemical equilibrium, an increase in temperature is disadvantageous for the formation of carboxymethylcellulose fibers; however, if the temperature is too low, the reaction rate is slow and the utilization of the etherifying agent is low. Therefore, the etherification reaction of the present invention is carried out at 30 to 120 ° C, preferably 70 ° C.
  • the carboxymethylated cellulose fibers are prepared in a one-step alkalization and etherification manner, i.e., the cellulose fibers are simultaneously subjected to an alkalization etherification reaction in a mixed solution.
  • the mass ratio of sodium hydroxide: sodium chloroacetate is 3: 1-1:3, the ethanol content is 20-70% by weight based on the total weight of the solution, and the water content is 50-80 based on the total weight of the solution. weight%.
  • the reaction temperature is 30-120 ° C, preferably 70 ° C; and the reaction time is 15-180 min, preferably 60 min.
  • a suitable washing sequence of the present invention is to wash twice with an acidic washing solution, followed by washing with a 1% by weight solution of Tween 20 in anhydrous ethanol, which is a water-ethanol solution of acetic acid. It comprises 2.5% by weight of acetic acid, 42.5% by weight of water and 55% by weight of ethanol, based on the total weight of the solution, and the mass ratio of the acidic washing liquid to the carboxymethylated cellulose fiber is 5 to 225.
  • the washed carboxymethylated cellulose fibers are air-dried at 30-80 ° C for 3-20 min, woven, packaged, and sterilized after shearing by a method known to those skilled in the art to obtain the present invention. Soluble hemostatic gauze.
  • Example 1 The invention is illustrated by the following examples in which all ratios (unless specifically stated) are by weight.
  • Example 1 The invention is illustrated by the following examples in which all ratios (unless specifically stated) are by weight.
  • lg of solvent-spun cellulose fiber (Lyocel filament, purchased from Hyosung Co., Korea) was dispersed by mechanical force at 50 ° C for 5 minutes at room temperature;
  • lg of solvent-spun cellulose fiber (Lyocel filament, purchased from Hyosung Co., Korea) was dispersed by mechanical force at 50 ° C for 5 minutes at room temperature;
  • solvent-spun cellulose fiber (Lyocel filament, purchased from Hyosung Co., Korea) was dispersed by mechanical force at 50 ° C for 5 minutes at room temperature;
  • the soluble hemostatic gauze of the present invention (Example 1 gauze) has a hemostatic effect.
  • the effect of soluble hemostatic gauze on the clotting time of rabbits was measured by spectrophotometer.
  • the soluble hemostatic gauze of the present invention was applied to the rabbit anticoagulant whole blood to which calcium chloride was added, and the OD was measured by a spectrophotometer at a wavelength of 541 nm. value.
  • the soluble hemostatic gauze of the present invention has a clotting time of 120 seconds based on the measured OD value, indicating that it has a hemostatic effect.
  • pH test 0.5 g of the soluble hemostatic gauze of the present invention (Example 7 gauze) was taken, and after dissolved in 100 ml of water, the pH was measured to be 7.5.
  • Chloride content detection Take 0.10g of soluble hemostatic gauze (Example 7 gauze) of the present invention, dissolve it by adding 250ml of water, dissolve it by micro-heat stirring, filter and cool, take 12.5ml of filtrate, and make a comparison with standard sodium chloride solution 5ml. The solution was compared to a chloride content of 0.85%.
  • Determination of the content of iron salt Take the soluble hemostatic gauze of the present invention (gauze of Example 7) l.Og, placed in a crucible, cooled to ash and then cooled, dissolved in 5 ml of dilute hydrochloric acid, added with appropriate amount of water, filtered, used Wash the filter device and residue with a small amount of water, combine the filtrate and washing solution, transfer to 50ml sodium colorimetric tube, add potassium permanganate test solution until purple is not fading, add 5ml of ammonium thiocyanate test solution, dilute with water To 50 ml, shake well, such as color development, the iron salt content is lower than the iron content of the control solution ( ⁇ 20 ppm) compared with the control solution prepared by the same method using 15 ml of the standard iron salt solution.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Textile Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Absorbent Articles And Supports Therefor (AREA)

Abstract

La présente invention concerne une gaze hémostatique soluble préparée par une fibre de cellulose filée dans un solvant carboxyméthylé. La présente invention concerne en outre un procédé de préparation d'une gaze hémostatique soluble, le procédé comprenant : l'utilisation d'une solution d'hydroxyde de sodium et d'une solution de chloroacétate de sodium séparément ou simultanément pour basifier et éthérifier la fibre de cellulose filée dans un solvant. Une fibre de carboxyméthylcellulose ayant une grande clarté, un degré élevé de substitution et une hydroscopicité élevée qui est utilisée pour préparer une gaze hémostatique soluble peut être obtenue à une température inférieure à l'aide du procédé.
PCT/CN2013/075728 2012-07-26 2013-05-16 Gaze hémostatique soluble et procédé de préparation associé WO2014015705A1 (fr)

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CN201210262307.XA CN103120802B (zh) 2012-07-26 2012-07-26 可溶性止血纱布及其制备方法
CN201210262307.X 2012-07-26

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CN109554914A (zh) * 2018-10-04 2019-04-02 南京航空航天大学溧水仿生产业研究院有限公司 吸湿排汗棉织物的制备方法
CN114478809A (zh) * 2022-02-21 2022-05-13 浙江隆腾医用新材料有限公司 一种羧甲基纤维素纤维的制备方法

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JP6807922B2 (ja) * 2015-10-07 2021-01-06 ライフサイエンス・プラス・インコーポレイテッドＬｉｆｅｓｃｉｅｎｃｅ Ｐｌｕｓ， Ｉｎｃ． 止血、組織障壁、創傷治癒、および美容術のための生体適合性カルボキシメチルセルロースマトリックス（ｂｃｍ）
CN107281534A (zh) * 2016-04-11 2017-10-24 宣晓星 一种天然竹纤维止血纱布的制作方法
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CN106362705A (zh) * 2016-11-01 2017-02-01 内江师范学院 羧甲基化纸浆纤维阳离子染料吸附材料及制备方法和用途
CN106421875B (zh) 2016-11-15 2019-08-27 广州迈普再生医学科技股份有限公司 可降解吸收的止血纤维材料及其制备方法和止血纤维制品
CN106474525A (zh) * 2016-11-16 2017-03-08 广东泰宝医疗科技股份有限公司 一种新型抗菌止血纱布及其制备方法
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CN107724074A (zh) * 2017-07-31 2018-02-23 山东人文置业有限公司 一种水溶性壳聚糖纤维的制备方法
JP2022128926A (ja) * 2021-02-24 2022-09-05 日本蚕毛染色株式会社 改質綿、これを含む紡績糸および繊維製品、ならびに改質綿の製造方法
CN113521374A (zh) * 2021-07-16 2021-10-22 山东省千佛山医院 血管外科用纳米止血抗菌复合材料及其制备方法
CN114645456B (zh) * 2022-03-24 2024-06-04 杭州叙源无纺布制品有限公司 一种含纤维素纤维凝胶化水刺无纺布的制备方法
CN114875571B (zh) * 2022-06-07 2023-04-28 广州宇然膜丽无纺制品有限公司 一种高吸水高透明无纺布及其制备方法与应用
CN115928418A (zh) * 2022-10-11 2023-04-07 佛山魔迪生物材料有限公司 一种阴阳离子改性的纤维素纤维无纺布及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1061061A (zh) * 1991-10-31 1992-05-13 江西化学纤维厂 一种可溶性棉布的制造方法
EP0616650B1 (fr) * 1991-12-10 1998-10-14 Courtaulds Plc Fibre de Carboxyméthylcellulose
CN1307489A (zh) * 1998-07-01 2001-08-08 厄苛迪斯特制纤维有限公司 绷带及其制备方法和合适使用的材料
CN101491688A (zh) * 2008-01-23 2009-07-29 王学洲 可溶性止血纱布及其制备方法
CN102580136A (zh) * 2011-01-07 2012-07-18 佛山市优特医疗科技有限公司 高吸湿且整片去除的伤口敷料

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1061061A (zh) * 1991-10-31 1992-05-13 江西化学纤维厂 一种可溶性棉布的制造方法
EP0616650B1 (fr) * 1991-12-10 1998-10-14 Courtaulds Plc Fibre de Carboxyméthylcellulose
CN1307489A (zh) * 1998-07-01 2001-08-08 厄苛迪斯特制纤维有限公司 绷带及其制备方法和合适使用的材料
CN101491688A (zh) * 2008-01-23 2009-07-29 王学洲 可溶性止血纱布及其制备方法
CN102580136A (zh) * 2011-01-07 2012-07-18 佛山市优特医疗科技有限公司 高吸湿且整片去除的伤口敷料

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109554914A (zh) * 2018-10-04 2019-04-02 南京航空航天大学溧水仿生产业研究院有限公司 吸湿排汗棉织物的制备方法
CN109554914B (zh) * 2018-10-04 2023-12-01 江苏品创纺织科技有限公司 吸湿排汗棉织物的制备方法
CN114478809A (zh) * 2022-02-21 2022-05-13 浙江隆腾医用新材料有限公司 一种羧甲基纤维素纤维的制备方法

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