WO2013136890A1 - 皮膚外用剤 - Google Patents

皮膚外用剤 Download PDF

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Publication number
WO2013136890A1
WO2013136890A1 PCT/JP2013/053201 JP2013053201W WO2013136890A1 WO 2013136890 A1 WO2013136890 A1 WO 2013136890A1 JP 2013053201 W JP2013053201 W JP 2013053201W WO 2013136890 A1 WO2013136890 A1 WO 2013136890A1
Authority
WO
WIPO (PCT)
Prior art keywords
external preparation
skin
molecular weight
average molecular
number average
Prior art date
Application number
PCT/JP2013/053201
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
洋明 小沢
佐代子 長谷川
由佳子 佐藤
Original Assignee
株式会社資生堂
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社資生堂 filed Critical 株式会社資生堂
Publication of WO2013136890A1 publication Critical patent/WO2013136890A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0254—Platelets; Flakes
    • A61K8/0258—Layered structure
    • A61K8/0262—Characterized by the central layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants

Definitions

  • the present invention relates to an external preparation for skin. More specifically, the present invention relates to a skin external preparation formulated with silver-supported tricalcium phosphate powder, which reduces or prevents whitening caused by silver-supported tricalcium phosphate powder.
  • Antibacterial tricalcium phosphate powder is blended in skin external preparations such as cosmetics and quasi drugs as a preservative and deodorant.
  • Patent Document 1 discloses a deodorant containing antibacterial tricalcium phosphate.
  • the deodorant has an object to provide a deodorant that removes malodors and efficiently sterilizes bacteria that decompose biological secretions to generate malodors, and is harmless to the living body.
  • Patent Document 1 neither describes nor suggests whitening that occurs when antibacterial tricalcium phosphate is blended.
  • a skin external preparation containing silver-carrying antibacterial tricalcium phosphate has a problem of whitening derived from silver-carrying antibacterial tricalcium phosphate. That is, when a skin external preparation containing silver-carrying antibacterial tricalcium phosphate is used, there is a problem of whitening that whiteness is conspicuous in the applied body part.
  • the present inventors have conducted extensive research to prevent whitening caused by silver-carrying antibacterial tricalcium phosphate powder in a skin external preparation formulated with silver-carrying antibacterial tricalcium phosphate powder.
  • Formulated with polypropylene glycol having a number average molecular weight of 700 to 4000, a copolymer of polypropylene glycol and polybutylene glycol having a number average molecular weight of 700 to 4000, or a derivative of polypropylene glycol having a number average molecular weight of 700 to 4000 Then, it discovered that the white after application
  • An object of the present invention is to provide a skin external preparation that reduces or prevents whitening derived from silver-supported antibacterial tricalcium phosphate powder in a skin external preparation containing silver-supported antibacterial tricalcium phosphate powder. is there.
  • the present invention relates to a combination of (A) silver-carrying antibacterial tricalcium phosphate, (B) polypropylene glycol having a number average molecular weight of 700 to 4000, polypropylene glycol having a number average molecular weight of 700 to 4000, and polybutylene glycol.
  • the present invention provides an external preparation for skin characterized by containing either a polymer or a derivative of polypropylene glycol having a number average molecular weight of 700 to 4000.
  • the (B) derivative of polypropylene glycol having a number average molecular weight of 700 to 4000 is a polyoxypropylene glyceryl ether having a number average molecular weight of 700 to 4000, and a polyoxypropylene sorbit having a number average molecular weight of 700 to 4000.
  • the above-mentioned external preparation for skin is characterized by being any one of polyoxypropylene butyl ether having a number average molecular weight of 700 to 4000.
  • the present invention provides the above-mentioned skin external preparation characterized by containing 30% by mass or more of ethanol with respect to the total amount of the skin external preparation.
  • the present invention also provides the above-mentioned external preparation for skin, wherein the external preparation for skin is a liquid cosmetic and is a deodorizing cosmetic filled in a roll-on container.
  • the present invention provides the above-mentioned external preparation for skin, wherein the external preparation for skin is a liquid cosmetic and is a mist-like deodorant cosmetic filled in an aerosol or dispenser container.
  • the present invention provides the above-mentioned external preparation for skin, wherein the external preparation for skin is a liquid cosmetic and is a sheet-like deodorant cosmetic impregnated in a sheet.
  • the effect of the present invention is that whitening derived from silver-carrying antibacterial tricalcium phosphate powder can be reduced or prevented in a skin external preparation containing silver-carrying antibacterial tricalcium phosphate powder.
  • silver-supported antibacterial tricalcium phosphate As the silver-supporting antibacterial tricalcium phosphate used as the component (A) in the present invention, a powder of tricalcium phosphate holding antibacterial silver in the tricalcium phosphate is used. A commercial item (Apacider C: Sangi Co., Ltd.) can be used in the present invention.
  • the compounding amount of the silver-supporting antibacterial tricalcium phosphate is 0.1 to 20% by mass, preferably 1 to 10% by mass, and more preferably 2 to 7% by mass with respect to the total amount of the external preparation for skin. It is determined appropriately according to the product form, and an appropriate amount is blended.
  • the component (B) blended to reduce or prevent whitening is as follows. One or more of the following (1) to (3) components (B) are blended.
  • Polypropylene glycol having a number average molecular weight of 700 to 4000 (2) Copolymer of polypropylene glycol and polybutylene glycol having a number average molecular weight of 700 to 4000 (3) Derivative of polypropylene glycol having a number average molecular weight of 700 to 4000 (Specifically, polyoxypropylene glyceryl ether having a number average molecular weight of 700 to 4000, polyoxypropylene sorbitol having a number average molecular weight of 700 to 4000, polyoxypropylene butyl ether having a number average molecular weight of 700 to 4000, etc.)
  • the number average molecular weight can be determined by the method described on page 942 of the Cosmetic Raw Material Standard, Second Edition Comment I (1984 Yakuji Nippo).
  • Polypropylene glycol having a number average molecular weight of 700 to 4000 is Newpol PP-1000 (Sanyo Chemical Industries Co., Ltd.) having a number average molecular weight of 1000, and Newpol PP-2000 (Sanyo Chemical Industries Co., Ltd.) having a number average molecular weight of 2000. Co., Ltd.) and Newpol PP-4000 (Sanyo Chemical Industries Co., Ltd.) having a number average molecular weight of 4000 can be preferably used.
  • Newpol GP-1000 (Sanyo Chemical Industry Co., Ltd.) having a number average molecular weight of 1000
  • Newpol GP-4000 (Sanyo Chemical Industries Co., Ltd.) having a number average molecular weight of 4000
  • polyoxypropylene sorbit Newpol SP-750 (Sanyo Chemical Industries Co., Ltd.) having a number average molecular weight of 700 can be preferably used.
  • Newpol LB-285 (Sanyo Chemical Industries Co., Ltd.) having a number average molecular weight of 1200
  • Newpol LB-625 (Sanyo Chemical Industries Co., Ltd.) having an average molecular weight of 1870 can be preferably used. .
  • the components (1) to (3) are components that are usually blended as a moisturizing agent in an external preparation for skin.
  • the white-floating substance derived from the silver-supported antibacterial tricalcium phosphate powder is used. It is an essential component that exhibits a reduction or prevention effect and is blended as a whitening reduction inhibitor.
  • Blending amount 0.1 to 20% by mass, preferably 1 to 20% by mass, more preferably 5 to 20% by mass, based on the total amount of the external preparation for skin.
  • the compounding quantity of a component is suitably determined according to a product form, and a suitable quantity is mix
  • the external preparation for skin of the present invention is not limited to the effects of the present invention, and other components that are usually blended in external preparations for skin such as cosmetics and quasi drugs, such as powder Ingredient, liquid fat, solid fat, wax, hydrocarbon oil, higher fatty acid, higher alcohol, ester oil, silicone oil, anionic surfactant, cationic surfactant, amphoteric surfactant, nonionic surfactant, moisturizer, Film agent, UV absorber, sequestering agent, lower alcohol, polyhydric alcohol, sugar, amino acid, organic amine, polymer emulsion, pH adjuster, skin nutrient, vitamin, antioxidant, antioxidant aid, fragrance Water or the like can be appropriately blended as necessary, and can be produced by a conventional method according to the intended dosage form.
  • cosmetics and quasi drugs such as powder Ingredient, liquid fat, solid fat, wax, hydrocarbon oil, higher fatty acid, higher alcohol, ester oil, silicone oil, anionic surfactant, cationic surfactant, amphoteric surfactant, nonionic surfactant, moisturizer
  • the dosage form of the present invention is not limited, but a liquid skin external preparation in which silver-supporting antibacterial tricalcium phosphate powder is dispersed is preferable.
  • ethanol is at least 30% by mass, preferably 30% by mass to 95% by mass with respect to the total amount of the external preparation for skin, from the viewpoint of increasing the solubility of the component B and imparting a refreshing feeling and quick drying.
  • a liquid skin external preparation blended by mass% is preferred.
  • the product form of the external preparation for skin of the present invention is not particularly limited.
  • liquid cosmetics in which silver-carrying antibacterial tricalcium phosphate powder is dispersed are (1) deodorant cosmetics filled in a roll-on container, (2) mist deodorant cosmetics filled in an aerosol or dispenser container, ( 3)
  • a product form such as a sheet-like deodorant cosmetic impregnated in a sheet such as a non-woven fabric is preferred, and these products are produced by a conventional method.
  • deodorant cosmetics such as powder type, pressed powder type, and stick type are produced by a conventional method as the external preparation for skin of the present invention.
  • a compounding quantity is the mass% with respect to the whole quantity unless there is particular notice.
  • a liquid cosmetic in which silver-carrying antibacterial tricalcium phosphate was dispersed was manufactured by a conventional method with the formulation shown in “Table 1”, and the whitening after application, which is an effect of the present invention, was confirmed by the following evaluation method. .
  • the following is a formulation example of the external preparation for skin of the present invention. Both are excellent in reducing and preventing whitening.
  • Prescription Example 1 Cosmetics suitable for roll-on containers (liquid cosmetics)” Compounding ingredients Mass% Ethanol Residual water 5 Silver-supported antibacterial tricalcium phosphate 1 Hydroxypropyl cellulose 0.2 Paraphenolsulfonic acid zinc salt 0.5 Polypropylene glycol (number average molecular weight 4000) 10
  • “Formulation Example 2 Cosmetics suitable for roll-on containers (liquid cosmetics)” Compounding ingredients Mass% Ethanol Residual water 5 Silver-supported antibacterial tricalcium phosphate 10 Hydroxypropyl cellulose 0.2 Paraphenolsulfonic acid zinc salt 0.5 Polypropylene glycol (number average molecular weight 2000) 10
  • “Formulation Example 4 Sheet-like deodorant cosmetic impregnated in sheet” Compounding ingredients Mass% Ethanol Residual water 40 Silver-supported antibacterial tricalcium phosphate 1 Talc 3 Paraphenolsulfonic acid zinc salt 0.5 Polyoxypropylene butyl ether 5 (Number average molecular weight 1870)
  • a skin external preparation that reduces or prevents whitening derived from silver-supported antibacterial tricalcium phosphate powder in a skin external preparation containing silver-supported antibacterial tricalcium phosphate powder.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)
PCT/JP2013/053201 2012-03-15 2013-02-12 皮膚外用剤 WO2013136890A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012058128A JP2013189409A (ja) 2012-03-15 2012-03-15 皮膚外用剤
JP2012-058128 2012-03-15

Publications (1)

Publication Number Publication Date
WO2013136890A1 true WO2013136890A1 (ja) 2013-09-19

Family

ID=49160809

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2013/053201 WO2013136890A1 (ja) 2012-03-15 2013-02-12 皮膚外用剤

Country Status (3)

Country Link
JP (1) JP2013189409A (zh)
TW (1) TW201345558A (zh)
WO (1) WO2013136890A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3157501A1 (en) * 2014-06-23 2017-04-26 Rohm and Haas Company Oil-free emollients in sunscreen compositions
BR112016028815A2 (pt) * 2014-06-23 2017-08-22 Rohm & Haas emolientes isentos de óleo em composições para cuidados pessoais

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08126690A (ja) * 1994-10-28 1996-05-21 Sangi Co Ltd 消臭剤
JP2005298418A (ja) * 2004-04-13 2005-10-27 Suzuki Yushi Kogyo Kk 抗菌性微粒子、その製造法及び該抗菌性微粒子を含む化粧料又は殺菌殺虫剤
JP2007210931A (ja) * 2006-02-09 2007-08-23 Shiseido Co Ltd 抗菌性ゼオライト及びこれを含有する皮膚外用剤
JP2007314527A (ja) * 2006-04-28 2007-12-06 Kao Corp 非水制汗デオドラントスティック組成物
JP2010248191A (ja) * 2009-04-15 2010-11-04 Evonik Goldschmidt Gmbh Ｄｍｃ触媒を使用して無臭ポリエーテルアルコールを調製する方法、並びに化粧品製剤および／又は皮膚用製剤におけるその使用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08126690A (ja) * 1994-10-28 1996-05-21 Sangi Co Ltd 消臭剤
JP2005298418A (ja) * 2004-04-13 2005-10-27 Suzuki Yushi Kogyo Kk 抗菌性微粒子、その製造法及び該抗菌性微粒子を含む化粧料又は殺菌殺虫剤
JP2007210931A (ja) * 2006-02-09 2007-08-23 Shiseido Co Ltd 抗菌性ゼオライト及びこれを含有する皮膚外用剤
JP2007314527A (ja) * 2006-04-28 2007-12-06 Kao Corp 非水制汗デオドラントスティック組成物
JP2010248191A (ja) * 2009-04-15 2010-11-04 Evonik Goldschmidt Gmbh Ｄｍｃ触媒を使用して無臭ポリエーテルアルコールを調製する方法、並びに化粧品製剤および／又は皮膚用製剤におけるその使用

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Publication number Publication date
JP2013189409A (ja) 2013-09-26
TW201345558A (zh) 2013-11-16

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