WO2013039350A2 - 세라마이드를 포함하는 피부 외용제 조성물 - Google Patents
세라마이드를 포함하는 피부 외용제 조성물 Download PDFInfo
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- WO2013039350A2 WO2013039350A2 PCT/KR2012/007378 KR2012007378W WO2013039350A2 WO 2013039350 A2 WO2013039350 A2 WO 2013039350A2 KR 2012007378 W KR2012007378 W KR 2012007378W WO 2013039350 A2 WO2013039350 A2 WO 2013039350A2
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- polyquaternium
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- 0 CCCCCCCCCC=CCC(CC(O)=O)C(N(*)CC(CO)O)=O Chemical compound CCCCCCCCCC=CCC(CC(O)=O)C(N(*)CC(CO)O)=O 0.000 description 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
Definitions
- the present invention relates to an external composition for skin comprising ceramide, and more specifically to a multi-layered ceramide lamellar structure comprising a glucoside surfactant having excellent skin moisturizing ability by forming a multilayer lamellar liquid crystal with ceramide, a method for preparing the same, and an external composition for skin containing the same It is about.
- the surface of human skin consists of keratinocytes that have differentiated from the basal layer and have matured keratinocytes. These keratinocytes are bound by the double-chain lamellar structure of ceramide, which is present in large amounts in the stratum corneum, thus maintaining a smooth and elastic skin.
- Ceramides are poorly soluble and are used in small amounts in cosmetic formulations, which in turn make the formulations less stable and cause gelation. If the particle size is small, the surface energy between the particles increases, and the attraction force is large. Since the ceramide can meet more conditions, the ceramide is not completely dispersed in the oil phase, and thus gelation occurs due to the binding between the ceramides, which is somewhat released into the water phase.
- a technique of inducing ceramide stabilization by making granules (grains) from ceramide, stearic acid and cholesterol, and adding them at the last stage in preparing an emulsion is applied.
- a method of making granules that stabilized ceramide externally first and then dispersing them in an emulsion a method of implementing stability by removing fluidity from solid ceramides made of solids is used.
- Korean Patent Application No. 2008-0072355 discloses a technique related to ceramide of a nuclear defrost using a solidification shell.
- this method also reduces the amount that can be used for the external skin preparation due to the large amount of encapsulating agent used in the encapsulation process of ceramide.
- the saccharide-based or macromolecular-based encapsulating agent in the feeling of use as an essential ingredient of the external skin preparations has a disadvantage in that it impairs the use of the unique external skin preparations.
- an object of the present invention is to provide a multi-layered ceramide lamella structure exhibiting an excellent skin moisturizing effect and skin barrier function recovery effect when applied to the skin, and an external skin composition comprising the same.
- the present invention provides a ceramide lamellar structure comprising a glucoside surfactant.
- the glucoside surfactant may be one or more selected from the group consisting of behenyl alcohol, arachidyl alcohol, arachidyl glucoside, C 14-22 alcohol and C 12-20 alkylglucoside.
- the ceramide lamella structure may further comprise a wax or oil.
- the wax may be one or more selected from the group consisting of alcohols, fatty acids, vegetable waxes, synthetic waxes, ozokerite, cetyl palmitate, beads waxes, lipids and lipid peptides.
- the oil may be an ester oil or a hydrocarbon oil.
- the ceramide may be any one or more of natural ceramides and similar ceramides.
- the pseudo ceramide may be one or more of the compounds represented by the following formula (1) -5.
- R is a saturated or unsaturated aliphatic chain of C 9 -C 21 .
- n 1 or 2;
- R and R ' are the same or different and each independently represent a saturated or unsaturated aliphatic chain of C 9 -C 21.
- n and n are the same or different and each independently represent an integer of 1 to 3;
- k and l are the same or different and each independently 1 or 2;
- j 0 or 1
- R and R ' are the same or different and each is independently a C 1 -C 31 straight or branched chain saturated or unsaturated alkyl group, with or without a hydroxy group;
- a 1 , A 2 and A 3 are the same or different, each independently hydrogen or one of the substituents of the following structure, except that A 1 , A 2 and A 3 are simultaneously hydrogen:
- M, M 1 and M 2 are the same or different, and each independently an alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium-7 , Polyquaternium-10, polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, L is alkaline earth metal.]
- R and R ' are the same or different and each is independently a C 10 -C 32 straight or branched chain saturated or unsaturated alkyl group, with or without a hydroxy group;
- R 3 and R 4 are the same or different and are each independently hydrogen or an alkyl or hydroxyalkyl group of C 1 -C 4 ;
- R 5 is -A or -CH 2 CH 2 OA, wherein A is any of substituents of the following structure.
- M, M 1 and M 2 are the same or different, and each independently an alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium-7 , Polyquaternium-10, polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, L is alkaline earth metal.]
- n and n are the same or different and each independently represent an integer of 1 to 4; R and R 'are the same or different and each independently represent a compound of C 1 -C 31 , which may or may not contain a hydroxy group Straight or branched, saturated or unsaturated alkyl groups;
- a 1 and A 2 are the same as or different from each other, and each independently hydrogen or any one of substituents of the following structure;
- M, M 1 and M 2 are the same or different, and each independently an alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium-7 , Polyquaternium-10, polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, L is an alkaline earth metal.
- the ceramide lamella structure may be formed by forming the multilayer lamella layer of the ceramide.
- the average particle size of the ceramide lamellar structure may be from 2 ⁇ m to 30 ⁇ m.
- the present invention also provides a topical skin composition comprising the ceramide lamellar structure.
- the ceramide may be contained from 0.01 to 20% by weight based on the total weight of the composition.
- the composition may be for skin moisturizing or skin elasticity enhancement.
- the composition may be a cosmetic composition or a pharmaceutical composition.
- the present invention comprises the steps of mixing the oil phase solution, the aqueous phase solution and the glucoside surfactant containing ceramide; It provides a method for producing a ceramide lamella structure comprising a; and leaving the mixed solution at 45 to 60 °C.
- the ceramide lamellar structure may be formed by a glucoside surfactant.
- the topical skin composition of the present invention has excellent stability in accordance with the stabilization of ceramide using a multilayer lamellar liquid crystal, and more ceramides can be stably formed, thereby having an excellent skin moisturizing effect and barrier function recovery effect when applying the skin.
- 1 is a graph showing the water evaporation amount according to the particle size of the liquid crystal containing the ceramide of the external preparation composition for skin according to an embodiment of the present invention.
- Figure 2 is a diagram showing a multi-layer lamellar layer of the external composition for skin according to an embodiment of the present invention.
- the present invention provides a multilayer ceramide lamellar structure comprising a glucoside surfactant.
- the present invention is a lamellar structure, the lamellar structure is a multi-layered liquid crystal, the lamellar structure comprises a ceramide and glucoside surfactant.
- the exterior of the structure is hydrophilic and the interior is hydrophobic, and is located between the exterior where the surfactant is hydrophilic and the interior that is hydrophobic.
- a glucoside surfactant is used as the surfactant.
- the lecithin-based, glucoside-based and sorbitan-based surfactants may be used to form the liquid crystal, but the lecithin-based and sorbitan-based surfactants make the particle size small, and thus it is difficult to realize the particle size required by the present invention.
- a glucoside surfactant is a surfactant that forms a large liquid crystal and has a long term stability.
- the glucoside surfactant used in the present invention may be one or more selected from the group consisting of behenyl alcohol, arachidyl alcohol, arachidyl glucoside, C 14-22 alcohol and C 12-20 alkyl glucoside, but is not limited thereto. .
- the multilayer ceramide lamella structure may further comprise a wax or oil. Waxes and oils help to form the interfacial film more firmly and are located in surfactants when further waxes and oils are included.
- the wax is not particularly limited as long as it is a wax used in creams, but is preferably selected from the group consisting of alcohols, fatty acids, vegetable waxes, synthetic waxes, ozokerite, cetyl palmitate, bees waxes, lipids and lipid peptides. It may be more than one species.
- the oil is not limited as long as it is a general oil, but may preferably be an ester oil or a hydrocarbon oil.
- the ester oil is isopropyl myristate, isopropyl palmitate, octyl-dodecyl myristate, cetyl octanoate, cetyl 2-ethyl hexanoate, C14-18 alkyl ethylhexatoate, coco-caprylate / Caprate and decyl cocoate
- di-ester based oils may include butylene glycol dicaprylate, dicaprate, diisostearyl malate, di-C12-13 alkyl malate, neopentyl glycol diheptanoate, tri Decyl stearate, naerpentyl glycol dicaprylate / dicaprate, tridecyl trimellitate and dicapriryl carbonate.
- Hydrocarbon oils may be hydrogenated polyisobutene
- the ceramide may be one or more selected from the group consisting of natural ceramide and pseudo ceramide.
- the natural ceramide is a natural ceramide, ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7, ceramide 8 and the like
- the pseudo ceramide is a ceramide 104 and ceramide And 102.
- Analogous ceramide in the present invention collectively refers to a compound having a double-chain lamellar structure, which is the structure of natural ceramide.
- the lamellar structure prevents the gelation of pseudo ceramide at the outer shell, and when the macroemulsion (macroemulsion) surrounded by the multi-lamellar layer is formed, the lamellar structure forms a multilayer of two or more layers. Contributes to good slipping and light usability.
- Rod type SAAs including ceramides, are generally known to be more stable with smaller curvature and larger radius of curvature.
- macroemulsions with small curvatures are more stable than emulsions of small particle sizes with large curvatures.
- FIG. 2 illustrates a multilayer lamellar layer of the external preparation composition for skin according to an embodiment of the present invention.
- the stability is known to increase by five times.
- the pseudo ceramide may be one or more of compounds represented by the following Chemical Formulas 1 to 5, but is not limited thereto.
- R is a saturated or unsaturated aliphatic chain of C 9 -C 21 .
- n 1 or 2;
- R and R ' are the same or different and each independently represent a saturated or unsaturated aliphatic chain of C 9 -C 21.
- n and n are the same or different and each independently represent an integer of 1 to 3;
- k and l are the same or different and each independently 1 or 2;
- j 0 or 1
- R and R ' are the same or different and each is independently a C 1 -C 31 straight or branched chain saturated or unsaturated alkyl group, with or without a hydroxy group;
- a 1 , A 2 and A 3 are the same or different, each independently hydrogen or one of the substituents of the following structure, except that A 1 , A 2 and A 3 are simultaneously hydrogen:
- M, M 1 and M 2 are the same or different, and each independently an alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium-7 , Polyquaternium-10, polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, L is alkaline earth metal.]
- R and R ' are the same or different and each is independently a C 10 -C 32 straight or branched chain saturated or unsaturated alkyl group, with or without a hydroxy group;
- R 3 and R 4 are the same or different and are each independently hydrogen or an alkyl or hydroxyalkyl group of C 1 -C 4 ;
- R 5 is -A or -CH 2 CH 2 OA, wherein A is any of substituents of the following structure.
- M, M 1 and M 2 are the same or different, and each independently an alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium-7 , Polyquaternium-10, polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, L is alkaline earth metal.]
- n and n are the same or different and each independently represent an integer of 1 to 4; R and R 'are the same or different and each independently represent a compound of C 1 -C 31 , which may or may not contain a hydroxy group Straight or branched, saturated or unsaturated alkyl groups;
- a 1 and A 2 are the same as or different from each other, and each independently hydrogen or any one of substituents of the following structure;
- M, M 1 and M 2 are the same or different, and each independently an alkali metal, lysine, arginine, histidine, triethanolamine, ammonia, polyquaternium-4, polyquaternium-6, polyquaternium-7 , Polyquaternium-10, polyquaternium-11, polyquaternium-16, lauryldimethylbenzylammonium chloride and stearyldimethylbenzylammonium chloride, L is an alkaline earth metal.
- the compounds of Formulas 1 to 5 are pseudoceramides having excellent effects on skin moisturizing and skin barrier function recovery.
- the multilayer ceramide lamellar structure ie, the multilayer lamella liquid crystal
- the average particle size of the multilayer ceramide lamellar structure, ie, the multilayer lamella liquid crystal may be 2 ⁇ m to 30 ⁇ m.
- the average particle size of the multilayer ceramide lamellar structure is formed to be 2 ⁇ m or more, it may lead to stabilization of pseudoceramide, and it may be possible to realize a special point of usability and to improve moisture retention.
- the average particle size exceeds 30 mu m, the stability is deteriorated, so it is preferable to maintain the above range.
- the present invention also provides a topical skin composition comprising the multilayer ceramide lamellar structure.
- the ceramide in the external preparation composition for skin is preferably contained in an amount of 0.01 to 20% by weight based on the total weight of the composition. More preferably, it may be contained in 0.05 to 10% by weight.
- the degree of stability is very excellent and can hold a large amount of moisture is very effective in skin moisturizing and barrier function recovery.
- the content is less than 0.01%, it is difficult to induce the desired moisture feeling and moisturizing power, and when it exceeds 20%, it is difficult to maintain the stability to maintain the above range.
- composition of the present invention may contain a certain amount of sparingly soluble substance in the composition due to the properties of the lamellar structure, which is a double layer structure, which may usually be ceramide 3B or the like.
- the external preparation composition for skin according to the present invention may be an external preparation composition for moisturizing skin or enhancing skin elasticity.
- the water content is increased by the multilayer lamellar liquid crystal formed by ceramide, and the skin barrier effect is improved, and thus it can be excellently used for moisturizing skin and enhancing skin elasticity.
- the external application composition for skin comprises the steps of mixing the oil phase solution, an aqueous solution and a glucoside surfactant containing ceramide; And leaving the mixed solution at 45 to 60 ° C., which may be prepared by a method for preparing a multilayer ceramide lamellar structure.
- the multilayer ceramide lamellar structure may be formed by a glucoside surfactant.
- the glucoside surfactant may be one or more selected from the group consisting of behenyl alcohol, arachidyl alcohol, arachidyl glucoside, C 14-22 alcohol and C 12-20 alkyl glucoside, but is not limited thereto.
- the temperature having a fluidity sufficiently present at an interface with a temperature below the melting point of the wax and oil to be applied is 45 to 60 ° C. That is, it is necessary to maintain the cooling within the temperature range to form a multi-layer lamellar liquid crystal having an average particle size of 2 ⁇ m to 30 ⁇ m.
- Multilayer lamellar liquid crystals having an average particle size of 2 ⁇ m to 30 ⁇ m may contribute to stabilization of pseudoceramide.
- non-uniformity of particle size occurs, which in turn compromises the stability of the final composition.
- the external preparation composition for skin according to the present invention may be, for example, a pharmaceutical composition or a cosmetic composition.
- the pharmaceutical composition may further contain pharmaceutical aids such as preservatives, stabilizers, hydrating or emulsifying accelerators, salts and / or buffers for controlling osmotic pressure, and other therapeutically useful substances, and various parenterals according to conventional methods. It may be formulated in a sphere dosage form. Parenteral dosage forms may be transdermal dosage forms, for example, but not limited to, lotion, ointment, gel, cream, patch or spray formulations.
- the dosage of the active ingredient is within the level of those skilled in the art, and the daily dosage of the drug depends on various factors such as less progression, onset, age, health condition, complications, etc. of the subject to be administered.
- the composition may be administered by dividing the composition 1 ⁇ g / kg to 200 mg / kg, preferably 50 ⁇ g / kg to 50 mg / kg once or three times a day, and the dosage may be any method. Also, the scope of the present invention is not limited.
- the cosmetic composition is not particularly limited in formulation, and may be appropriately selected as desired.
- softening cream skin lotion and milk lotion
- nourishing cream essence
- nourishing cream massage cream, pack, gel, essence
- eye cream eye essence
- cleansing cream cleansing foam
- cleansing water cleansing water, pack, powder
- the content of the active ingredient is not particularly limited, but may be included in an amount of 0.01 to 10% by weight based on the total weight of the composition. When the active ingredient satisfies the content, it may exhibit excellent efficacy without side effects.
- the cosmetic composition may also include cosmetically acceptable excipients that act as diluents, dispersants or carriers so that the composition is easy to distribute when applied to the skin.
- the composition is an oil-in-water (O / W) emulsion, and the emulsion preferably contains at least 80% by weight of water in excipients.
- O / W oil-in-water
- the present invention is not limited thereto, and any known excipient that is acceptable for cosmetic use may be used.
- the cosmetic composition is a cosmetic auxiliary agents commonly used in the field of the present invention, such as fatty substances, organic solvents, silicon, thickeners, softeners, supplemental sunscreens, foam inhibitors, moisturizers, fragrances, preservatives, surface active agents, Total materials, containment agents, cationic, anionic, nonionic or amphoteric polymers or mixtures thereof, propellants, basicizing or acidifying agents, dyes, pigments or nanopigments (especially in the case of UV radiation physically) By blocking to provide a photoprotective effect), or other components commonly used in cosmetics, in particular in the manufacture of sunscreen compositions.
- fatty substances such as fatty substances, organic solvents, silicon, thickeners, softeners, supplemental sunscreens, foam inhibitors, moisturizers, fragrances, preservatives, surface active agents, Total materials, containment agents, cationic, anionic, nonionic or amphoteric polymers or mixtures thereof, propellants, basicizing or acidifying agents, dyes, pigments or nanopigments (
- organic solvents lower alcohols and polyols such as ethanol, isopropanol, propylene glycol, glycerol, sorbitol and the like can be mentioned.
- Fatty substances may consist of oils or waxes or mixtures thereof, fatty acids, fatty acid esters, fatty alcohols, petrolatum, paraffin, lanolin, lanolin hydride or acetylated lanolin.
- the oils may be chosen from animal, vegetable, mineral or synthetic oils, in particular hydrogenated palm oil, hydrogenated castor oil, liquid petrolatum, liquid paraffin, purcellin oil, volatile or nonvolatile silicone oil and isoparaffin.
- the cosmetic composition is a sunscreen composition for protecting the epidermis of the human body from ultraviolet rays
- it may take the form of a suspension or dispersion of a solvent or a fatty substance, or alternatively an emulsion such as a cream or an emulsion (especially oil in oil) -in-water (O / W) or water-in-oil type, but preferably O / W), or in the form of vesicle dispersions, or ointments, gels, solid sticks or aerosols It may take the form of a bubble.
- the emulsion may further comprise anionic, nonionic, cationic or amphoteric surfactant.
- the cosmetic composition when used for hair protection, it may be used in the form of a shampoo, lotion, gel or rinse composition, before or after hair curling, before or after dyeing or bleaching, during or before wave perm or straight perm. It may take the form of a styling or treatment lotion or gel, a dryer or a hair setter lotion or gel, a hair lacquer or a composition for wave or straight perm of the hair, or a composition for dyeing or decolorizing hair. There is a number.
- the cosmetic composition is used for eyelashes, eyebrows, skin or hair makeup products, such as skin treatment creams, foundation creams, lipsticks, eyeshadows, rouge, eyeliner, mascara or coloring gel , Solid or paste and anhydrous or aqueous, such as oil-in-water or water-in-oil emulsions, suspensions or gels.
- the present invention also relates to a skin disease treatment agent comprising the external preparation composition for skin, wherein the skin disease is not particularly limited, and may be, for example, acne, psoriasis, hair loss or keratin abnormalities.
- the present invention relates to an external preparation for skin comprising the external preparation for external skin, wherein the external preparation for skin is a generic term that may include anything applied outside the skin, and cosmetics and medicines of various formulations may be included therein.
- the external preparation for skin is also not particularly limited, but may be, for example, an external preparation for preventing skin aging or improving skin wrinkles.
- step 1) The oily solution of step 1) was added to the aqueous solution of step 2) and mixed by stirring with a homomixer.
- Example 1 maintained the cooling temperature at about 52 ° C. for about 35 minutes. In addition, Comparative Example 1 rapidly cooled to 30 ° C in 5 minutes.
- Example 1 The cosmetics of Example 1 and Comparative Example 1 were prepared by removing bubbles of the mixture of 4).
- Example 1 and Comparative Example 1 a test was conducted to confirm the difference in stability according to the particle size produced differently depending on the cooling temperature.
- the state of each composition was confirmed in the refrigeration (4 °C), freezing (-18 °C), 30 °C, 45 °C constant temperature bath, the results are shown in the following table 2 is described.
- Example 1 a multilayer lamellar liquid crystal having a particle size of 2 ⁇ m or more was formed, which showed stability for 6 months at 45 ° C., indicating that the image stability was excellent. This indicates that the multilayer lamellar liquid crystal formed by controlling the cooling temperature of the composition containing pseudoceramide has an excellent effect in preventing gelation of pseudoceramide.
- Example 1 With Example 1 and Comparative Example 1, the experiment was carried out for the difference in the amount of water evaporation according to the particle size of the liquid crystal containing pseudoceramide and the presence of pseudoceramide.
- the test was conducted by measuring the moisture evaporation amount over time using a humidity controller and an electronic balance. More specifically, the experimental environment was controlled to a humidity of 29 ⁇ 1% by using a desiccator, and the temperature displacement was adjusted to 24 ⁇ 2 °C by experimenting in a constant temperature and humidity room. Under these constant temperature and humidity conditions, mass changes during one hour of a formulation coated with 290 mg of artificial leather having a mass of 35 mg in an area of 25 cm 2 were analyzed. The result is shown in FIG.
- Example 1 As shown in FIG. 1, it was found that the formulation having the large particle size having the final residual amount of water in Example 1 was the highest.
- the slope of the curve represents the evaporation rate of bound water, which means that the lower the value, the longer the water retained.
- this inclination value the case of Example 1 was even better, and it was found that the second position was in the order of Comparative Example 1 having a small liquid crystal size containing pseudo ceramide.
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Abstract
Description
성분(단위: 중량 %) | |
1. 부틸렌글라이콜디카프릴레이트/디카프레이트 | 4.00 |
2. 하이드록시프로필비스라우라마이드엠이에이(Pc104) | 0.70 |
3. 하이드록시프로필비스팔미타마이드엠이에이(Pc102) | 0.80 |
4. 콜레스테롤 | 0.50 |
5. 스테아릭애씨드 | 1.50 |
6. 베헤닐알코올 | 2.00 |
7. 베헤닐알코올,아라키딜알코올,아라키딜글루코사이드 | 1.00 |
8. C14-22알코올, C12-20알킬글루코사이드 | 1.00 |
9. 펜타에리스리틸테트라이소스테아레이트 | 4.00 |
10. 세틸에칠헥사노에이트 | 3.00 |
11. 스쿠알란 | 3.00 |
12. 사이클로펜타실록산 | 4.00 |
13. 사이클로펜타실록산,디메치콘올 | 1.00 |
14. 정제수 | To 100 |
15. 글리세린 | 5.00 |
16. 부틸렌글라이콜 | 10.00 |
17. 트로메타민 | 0.05 |
18. 방부제 | 적량 |
냉장(4℃) | 냉동(-18℃) | 30℃ | 45℃ | |
실시예1 | 안정 | 안정 | 안정 | 6달 안정 |
비교예1 | 안정 | 안정 | 불안정 | 겔화(gelation) |
Claims (19)
- 글루코사이드 계면활성제를 포함하는 세라마이드 라멜라 구조체.
- 제 1항에 있어서,상기 글루코사이드 계면활성제는 베헤닐알코올, 아라키딜알코올, 아라키딜글루코사이드, C14-22 알코올 및 C12-20 알킬글루코사이드로 이루어진 군에서 선택된 1종 이상인 것인 세라마이드 라멜라 구조체.
- 제 1항에 있어서,상기 세라마이드 라멜라 구조체는 왁스 또는 오일을 더 포함하는 것인 세라마이드 라멜라 구조체.
- 제 3항에 있어서,상기 왁스는 알코올, 지방산, 식물성 왁스, 합성 왁스, 오조케라이트, 세틸 팔미테이트, 비즈 왁스, 지질 및 지질 펩타이드로 이루어진 군에서 선택된 1종 이상인 것인 세라마이드 라멜라 구조체.
- 제 3항에 있어서,상기 오일은 에스테르 오일 또는 하이드로카본 오일인 세라마이드 라멜라 구조체.
- 제 1항에 있어서,상기 세라마이드는 천연 세라마이드 및 유사 세라마이드 중 어느 하나 이상인 것인 세라마이드 라멜라 구조체.
- 제 6항에 있어서,상기 유사 세라마이드는 하기 화학식 1 내지 5로 표시되는 화합물 중 하나 이상인 것인 세라마이드 라멜라 구조체.화학식 1(상기 식에서, R은 C9-C21 의 포화 또는 불포화 지방족 사슬이다.)화학식 2(상기 식에서, n은 1 또는 2이고;R 및 R'는 같거나 다르며, 각각 독립적으로 C9-C21의 포화 또는 불포화 지방족 사슬이다.)화학식 3(상기 식에서,m 및 n은 같거나 다르며, 각각 독립적으로 1 내지 3 중 하나의 정수이고;k 및 l은 같거나 다르며, 각각 독립적으로 1 또는 2이며;j는 0 또는 1이며;R 및 R'는 같거나 다르며, 각각 독립적으로 히드록시기를 함유하거나 함유하지 않은, C1-C31의 직쇄 또는 분지쇄의 포화 또는 불포화 알킬기이며;A1, A2 및 A3는 같거나 다르며, 각각 독립적으로 수소 또는 하기 구조의 치환기 중의 어느 하나이고, 단 A1, A2 및 A3가 동시에 수소인 경우는 제외된다:[상기 식에서, M, M1및 M2는 같거나 다르며, 각각 독립적으로 알칼리 금속, 리신, 아르기닌, 히스티딘, 트리에탄올아민, 암모니아, 폴리쿼터늄-4, 폴리쿼터늄-6, 폴리쿼터늄-7, 폴리쿼터늄-10, 폴리쿼터늄-11, 폴리쿼터늄-16, 라우릴디메틸벤질암모늄클로라이드 및 스테아릴디메틸벤질암모늄클로라이드로 이루어진 군으로부터 선택되고, L은 알칼리토금속이다.]),화학식 4(상기 식에서, R 및 R'는 같거나 다르며, 각각 독립적으로 히드록시기를 함유하거나 함유하지 않은, C10-C32의 직쇄 또는 분지쇄의 포화 또는 불포화 알킬기이고;R3 및 R4는 같거나 다르며, 각각 독립적으로 수소 또는 C1-C4의 알킬기 또는 히드록시알킬기이며;R5는 -A 또는 -CH2CH2OA이며, 여기에서 A는 하기 구조의 치환기 중의 어느 하나이다.[상기 식에서, M, M1및 M2는 같거나 다르며, 각각 독립적으로 알칼리금속, 리신, 아르기닌, 히스티딘, 트리에탄올아민, 암모니아, 폴리쿼터늄-4, 폴리쿼터늄-6, 폴리쿼터늄-7, 폴리쿼터늄-10, 폴리쿼터늄-11, 폴리쿼터늄-16, 라우릴디메틸벤질암모늄클로라이드 및 스테아릴디메틸벤질암모늄클로라이드로 이루어진 군으로부터 선택되고, L은 알칼리토금속이다.]),화학식 5(상기 식에서, m 및 n은 같거나 다르며, 각각 독립적으로 1 내지 4 중 하나의 정수이고; R 및 R'은 같거나 다르며, 각각 독립적으로 히드록시기를 함유하거나 함유하지 않은, C1-C31의 직쇄 또는 분지쇄의 포화 또는 불포화 알킬기이며;A1 및 A2는 같거나 다르며, 각각 독립적으로 수소 또는 하기 구조의 치환기 중 어느 하나이다;[상기 식에서, M, M1및 M2는 같거나 다르며, 각각 독립적으로 알칼리금속, 리신, 아르기닌, 히스티딘, 트리에탄올아민, 암모니아, 폴리쿼터늄-4, 폴리쿼터늄-6, 폴리쿼터늄-7, 폴리쿼터늄-10, 폴리쿼터늄-11, 폴리쿼터늄-16, 라우릴디메틸벤질암모늄클로라이드 및 스테아릴디메틸벤질암모늄클로라이드로 이루어진 군으로부터 선택되고, L은 알칼리토금속이다.])
- 제 1항에 있어서,상기 세라마이드 라멜라 구조체는 상기 세라마이드가 다층의 라멜라 층을 형성하여 이루어지는 것인 세라마이드 라멜라 구조체.
- 제 1항에 있어서,상기 세라마이드 라멜라 구조체의 평균 입자 크기는 2㎛ 내지 30㎛인 것인 세라마이드 라멜라 구조체.
- 제 1항 내지 제 9항 중 어느 한 항의 세라마이드 라멜라 구조체를 포함하는 피부 외용제 조성물.
- 제 10항에 있어서,상기 세라마이드는 조성물 총 중량을 기준으로 0.01 내지 20중량% 함유되는 것인 피부 외용제 조성물.
- 제 10항에 있어서,상기 조성물은 피부 보습용 또는 피부 탄력 증진용인 것인 피부 외용제 조성물.
- 제 10항에 있어서,상기 조성물은 화장료 조성물 또는 약학 조성물인 것인 피부 외용제 조성물.
- 세라마이드를 함유하는 유상 용액, 수상 용액 및 글루코사이드 계면활성제를 혼합하는 단계; 및 상기 혼합 용액을 45 내지 60℃에서 방치하는 단계;를 포함하는 세라마이드 라멜라 구조체의 제조방법.
- 제 14항에 있어서,상기 세라마이드는 천연 세라마이드 및 유사 세라마이드 중 어느 하나 이상인 것인 세라마이드 라멜라 구조체의 제조방법.
- 제 14항에 있어서,상기 세라마이드 라멜라 구조는 글루코사이드 계면활성제에 의해 형성되는 것인 세라마이드 라멜라 구조체의 제조방법.
- 제 14항에 있어서,상기 글루코사이드 계면활성제는 베헤닐알코올, 아라키딜알코올, 아라키딜글루코사이드, C14-22 알코올 및 C12-20 알킬글루코사이드로 이루어진 군에서 선택된 1종 이상인 것인 세라마이드 라멜라 구조체의 제조방법.
- 제 15항에 있어서,상기 유사 세라마이드는 하기 화학식 1 내지 5로 표시되는 화합물 중 하나 이상인 것인 세라마이드 라멜라 구조체의 제조방법.화학식 1(상기 식에서, R은 C9-C21 의 포화 또는 불포화 지방족 사슬이다.)화학식 2(상기 식에서, n은 1 또는 2이고;R 및 R'는 같거나 다르며, 각각 독립적으로 C9-C21의 포화 또는 불포화 지방족 사슬이다.)화학식 3(상기 식에서,m 및 n은 같거나 다르며, 각각 독립적으로 1 내지 3 중 하나의 정수이고;k 및 l은 같거나 다르며, 각각 독립적으로 1 또는 2이며;j는 0 또는 1이며;R 및 R'는 같거나 다르며, 각각 독립적으로 히드록시기를 함유하거나 함유하지 않은, C1-C31의 직쇄 또는 분지쇄의 포화 또는 불포화 알킬기이며;A1, A2 및 A3는 같거나 다르며, 각각 독립적으로 수소 또는 하기 구조의 치환기 중의 어느 하나이고, 단 A1, A2 및 A3가 동시에 수소인 경우는 제외된다:[상기 식에서, M, M1및 M2는 같거나 다르며, 각각 독립적으로 알칼리 금속, 리신, 아르기닌, 히스티딘, 트리에탄올아민, 암모니아, 폴리쿼터늄-4, 폴리쿼터늄-6, 폴리쿼터늄-7, 폴리쿼터늄-10, 폴리쿼터늄-11, 폴리쿼터늄-16, 라우릴디메틸벤질암모늄클로라이드 및 스테아릴디메틸벤질암모늄클로라이드로 이루어진 군으로부터 선택되고, L은 알칼리토금속이다.]),화학식 4(상기 식에서, R 및 R'는 같거나 다르며, 각각 독립적으로 히드록시기를 함유하거나 함유하지 않은, C10-C32의 직쇄 또는 분지쇄의 포화 또는 불포화 알킬기이고;R3 및 R4는 같거나 다르며, 각각 독립적으로 수소 또는 C1-C4의 알킬기 또는 히드록시알킬기이며;R5는 -A 또는 -CH2CH2OA이며, 여기에서 A는 하기 구조의 치환기 중의 어느 하나이다.[상기 식에서, M, M1및 M2는 같거나 다르며, 각각 독립적으로 알칼리금속, 리신, 아르기닌, 히스티딘, 트리에탄올아민, 암모니아, 폴리쿼터늄-4, 폴리쿼터늄-6, 폴리쿼터늄-7, 폴리쿼터늄-10, 폴리쿼터늄-11, 폴리쿼터늄-16, 라우릴디메틸벤질암모늄클로라이드 및 스테아릴디메틸벤질암모늄클로라이드로 이루어진 군으로부터 선택되고, L은 알칼리토금속이다.]),화학식 5(상기 식에서, m 및 n은 같거나 다르며, 각각 독립적으로 1 내지 4 중 하나의 정수이고; R 및 R'은 같거나 다르며, 각각 독립적으로 히드록시기를 함유하거나 함유하지 않은, C1-C31의 직쇄 또는 분지쇄의 포화 또는 불포화 알킬기이며;A1 및 A2는 같거나 다르며, 각각 독립적으로 수소 또는 하기 구조의 치환기 중 어느 하나이다;[상기 식에서, M, M1및 M2는 같거나 다르며, 각각 독립적으로 알칼리금속, 리신, 아르기닌, 히스티딘, 트리에탄올아민, 암모니아, 폴리쿼터늄-4, 폴리쿼터늄-6, 폴리쿼터늄-7, 폴리쿼터늄-10, 폴리쿼터늄-11, 폴리쿼터늄-16, 라우릴디메틸벤질암모늄클로라이드 및 스테아릴디메틸벤질암모늄클로라이드로 이루어진 군으로부터 선택되고, L은 알칼리토금속이다.])
- 제 14항에 있어서,상기 세라마이드 라멜라 구조체의 평균 입자 크기는 2㎛ 내지 30㎛인 것인 세라마이드 라멜라 구조체의 제조방법.
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CN201280045289.8A CN103796641A (zh) | 2011-09-16 | 2012-09-14 | 包含神经酰胺的皮肤外用组合物 |
US14/342,967 US9155793B2 (en) | 2011-09-16 | 2012-09-14 | Skin composition for external use containing ceramides |
JP2014530593A JP6248038B2 (ja) | 2011-09-16 | 2012-09-14 | セラミドラメラ構造体及びそれを含む皮膚外用剤組成物 |
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---|---|---|---|---|
WO2015080521A1 (ko) * | 2013-11-29 | 2015-06-04 | 주식회사 아모레퍼시픽 | 라멜라 액정 구조를 가지는 모발용 화장료 조성물 |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20020076874A (ko) * | 2001-03-31 | 2002-10-11 | 엔프라니 주식회사 | 저자극성 및 고보습형 화장료 조성물 |
US7169382B2 (en) * | 2003-01-30 | 2007-01-30 | L'oreal | Reconstructed epidermis/skin equivalent comprising a ceramide 7 and /or 5.5 and lipid lamellar vesicular compositions comprising ceramide 7 and/or 5.5 compounds |
KR100678790B1 (ko) * | 2006-01-31 | 2007-02-02 | (주)아모레퍼시픽 | 자외선 차단용 수중유형 유화 화장료 조성물 |
KR20100026143A (ko) * | 2008-08-29 | 2010-03-10 | (주)아모레퍼시픽 | 다층 라멜라 과립 및 이를 함유하는 피부외용제 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2673179B1 (fr) * | 1991-02-21 | 1993-06-11 | Oreal | Ceramides, leur procede de preparation et leurs applications en cosmetique et en dermopharmacie. |
US5576016A (en) * | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
JP3397956B2 (ja) * | 1995-12-11 | 2003-04-21 | 花王株式会社 | 皮膚化粧料 |
KR100352986B1 (ko) * | 2000-04-28 | 2002-09-18 | 주식회사 태평양 | 세라미드 유사 화합물 및 이의 제조방법, 및 이를함유하는 화장료 조성물 |
EP1443108A3 (fr) * | 2003-01-30 | 2005-10-12 | L'oreal | Procédés de préparation d'un épiderme reconstruit supplémenté en céramide 7 ou 5.5, composition à base de vésicules lamellaires lipidiques incorporant un dérivé du céramide 7 et/ou 5.5 et son utilisation |
EP2317981B1 (en) * | 2008-07-24 | 2013-11-13 | Amorepacific Corporation | Multi-layered lamellar granule and skin external application composition containing same |
-
2011
- 2011-09-16 KR KR1020110093634A patent/KR101803902B1/ko active IP Right Grant
-
2012
- 2012-09-14 CN CN201810356410.8A patent/CN108524479A/zh active Pending
- 2012-09-14 CN CN201280045289.8A patent/CN103796641A/zh active Pending
- 2012-09-14 JP JP2014530593A patent/JP6248038B2/ja active Active
- 2012-09-14 WO PCT/KR2012/007378 patent/WO2013039350A2/ko active Application Filing
- 2012-09-14 US US14/342,967 patent/US9155793B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20020076874A (ko) * | 2001-03-31 | 2002-10-11 | 엔프라니 주식회사 | 저자극성 및 고보습형 화장료 조성물 |
US7169382B2 (en) * | 2003-01-30 | 2007-01-30 | L'oreal | Reconstructed epidermis/skin equivalent comprising a ceramide 7 and /or 5.5 and lipid lamellar vesicular compositions comprising ceramide 7 and/or 5.5 compounds |
KR100678790B1 (ko) * | 2006-01-31 | 2007-02-02 | (주)아모레퍼시픽 | 자외선 차단용 수중유형 유화 화장료 조성물 |
KR20100026143A (ko) * | 2008-08-29 | 2010-03-10 | (주)아모레퍼시픽 | 다층 라멜라 과립 및 이를 함유하는 피부외용제 조성물 |
Non-Patent Citations (1)
Title |
---|
DO-HOON, KIM ET AL.: 'Formation and Dispersion of Stable Lamellar Structure Containing Ceramide' J. SOC. COSMET. SCIENTISTS KOREA vol. 35, no. 3, 2009, pages 171 - 177 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015080521A1 (ko) * | 2013-11-29 | 2015-06-04 | 주식회사 아모레퍼시픽 | 라멜라 액정 구조를 가지는 모발용 화장료 조성물 |
KR20150062994A (ko) * | 2013-11-29 | 2015-06-08 | (주)아모레퍼시픽 | 레시틴 계열의 계면활성제를 사용하여 라멜라 액정 구조를 가지는 모발용 화장료 조성물 |
KR20150062992A (ko) * | 2013-11-29 | 2015-06-08 | (주)아모레퍼시픽 | 글루코스 계열의 계면활성제를 사용하여 라멜라 액정 구조를 가지는 모발용 화장료 조성물 |
KR20150062993A (ko) * | 2013-11-29 | 2015-06-08 | (주)아모레퍼시픽 | 소르비탄 계열의 계면활성제를 사용하여 라멜라 액정 구조를 가지는 모발용 화장료 조성물 |
KR102261316B1 (ko) * | 2013-11-29 | 2021-06-08 | (주)아모레퍼시픽 | 레시틴 계열의 계면활성제를 사용하여 라멜라 액정 구조를 가지는 모발용 화장료 조성물 |
KR102261311B1 (ko) * | 2013-11-29 | 2021-06-08 | (주)아모레퍼시픽 | 글루코스 계열의 계면활성제를 사용하여 라멜라 액정 구조를 가지는 모발용 화장료 조성물 |
KR102261313B1 (ko) * | 2013-11-29 | 2021-06-08 | (주)아모레퍼시픽 | 소르비탄 계열의 계면활성제를 사용하여 라멜라 액정 구조를 가지는 모발용 화장료 조성물 |
US20180344587A1 (en) * | 2015-03-31 | 2018-12-06 | Amorepacific Corporation | Cosmetic composition with multiple emulsion formulation having lamellar liquid crystal structure |
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US20140220139A1 (en) | 2014-08-07 |
US9155793B2 (en) | 2015-10-13 |
CN103796641A (zh) | 2014-05-14 |
KR20130030093A (ko) | 2013-03-26 |
KR101803902B1 (ko) | 2017-12-04 |
WO2013039350A3 (ko) | 2013-05-10 |
JP2014530187A (ja) | 2014-11-17 |
JP6248038B2 (ja) | 2017-12-13 |
CN108524479A (zh) | 2018-09-14 |
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