WO2012130457A1 - Carte de porte-échantillon et procédé d'extraction automatique et d'analyse directe d'échantillons - Google Patents

Carte de porte-échantillon et procédé d'extraction automatique et d'analyse directe d'échantillons Download PDF

Info

Publication number
WO2012130457A1
WO2012130457A1 PCT/EP2012/001390 EP2012001390W WO2012130457A1 WO 2012130457 A1 WO2012130457 A1 WO 2012130457A1 EP 2012001390 W EP2012001390 W EP 2012001390W WO 2012130457 A1 WO2012130457 A1 WO 2012130457A1
Authority
WO
WIPO (PCT)
Prior art keywords
sample carrier
sample
card
extraction
layer
Prior art date
Application number
PCT/EP2012/001390
Other languages
German (de)
English (en)
Inventor
Werner DÖBELIN
Original Assignee
Doebelin Werner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Doebelin Werner filed Critical Doebelin Werner
Priority to EP12720784.3A priority Critical patent/EP2691765A1/fr
Publication of WO2012130457A1 publication Critical patent/WO2012130457A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N2030/009—Extraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N2030/062—Preparation extracting sample from raw material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/08—Preparation using an enricher

Definitions

  • the invention relates to a sample carrier card with integrated sample carrier for analytical measuring methods and a method for direct and automated analysis of samples by extraction of the sample from at least one sample carrier, which is embedded in said sample carrier card, preferably in the context of HPLC analysis in a HPLC system ,
  • sample carrier card with integrated sample carrier for analytical measuring methods and a method for direct and automated analysis of samples by extraction of the sample from at least one sample carrier, which is embedded in said sample carrier card, preferably in the context of HPLC analysis in a HPLC system .
  • WO 2011/151083 has disclosed a method and a device for the direct analysis of medical, pharmaceutical, biological, biochemical and / or chemical samples by means of HPLC, wherein the sample having at least one analyte is applied to a sample carrier in liquid form and is dried. As a result, the sample is located on the sample carrier as a so-called “dried spot.”
  • the adapter is clamped in place between two adapters of an adapter system an extraction agent is supplied via a feed line, and the other adapter is used as an output adapter with a discharge line
  • CONFIRMATION COPY connected. In this way, the clamped sample carrier is flowed through and the sample is washed out of the sample carrier.
  • the method disclosed therein enables the extraction of “dried spots”, in particular “dried blood spots” (DBS), without punching them out, as otherwise usual and known.
  • DBS dried blood spots
  • the extraction takes place through the sample carrier by means of a defined amount of solvent and a defined flow direction.
  • the said conventional sample carriers are usually made of coated or uncoated paper or pressed cotton fibers, because this allows a simple punching of the sample.
  • sample carrier cards are made of paper or cardboard and can be easily deformed. In addition, they absorb easily air humidity. This results in disadvantages in handling and in the automated extraction and measuring method. Also, today's requirements for logistics and security can only be taken into account to a limited extent. With regard to sample safety, the need for a clear allocation of each sample, which increases with the sample throughput during an analysis, should be mentioned in particular.
  • the object of the invention is therefore to provide a sample carrier card and a method for the direct analysis of samples by extraction of the sample from at least one sample carrier, with which automated extraction and direct analysis of samples is made possible and facilitated without the sample to punch out the analysis and with a mix-free allocation possibility of the analyzed samples and sample conditions.
  • sample carrier card with an integrated sample carrier for analytical measuring methods, in which the sample carrier for direct recording of a sample to be measured is at least two-layered and has at least one extraction layer and at least one filter layer.
  • the sample carrier is embedded in a sample carrier front card and a sample carrier return card, which together form the sample carrier card.
  • the inventive sample carrier card can provide a defined sample application page.
  • the sample carrier accordingly has a defined extraction direction and is not punched out for extraction. Since a filter layer is additionally provided and passed, the sample extraction with a defined flow can take place within the framework of an automated sample analysis, for example in an HPLC system, and be analyzed directly after the extraction.
  • the sample carrier card can have at least one sample application area. Accordingly, the sample carrier front card and the sample carrier return card can in turn each have at least one recess, the respective at least one recess being arranged above the at least one sample application region. In this way, it is ensured that each sample application area is exposed to the outside of both sample carrier front card side and sample carrier backcard side.
  • the sample carrier front card and the sample carrier return card can each be made of plastic. It is meant a stable plastic, which gives the sample carrier card stability about a check or credit card. This stability makes it possible to insert the sample carrier card into an analysis system, such as an HPLC analysis system for a clamp in direct analysis of the extracted sample (s) without damaging the sample carrier card. To be particularly advantageous in this material also mention that it does not absorb moisture and thus remains dimensionally stable.
  • the extraction layer and / or the filter layer can be selected from microfibers, microfibre fabric, filter fabric, paper, cotton fibers and / or porous plastic.
  • the extraction layer and the filter layer are particularly important to note that they are composed of a combination of a rather tough, more robust and mechanically more stable and a softer layer.
  • the rather tough and more mechanically stable layer should serve as an extraction layer, while the softer layer is more suitable as a filter layer.
  • the extraction layer and / or the filter layer may also have a chemically bonded coating. Over the chemically bound coating can e.g. be ensured that the sample carrier, i. the extraction layer and / or the filter layer, also has chromatographic properties.
  • the sample carrier is constructed from two to four layers.
  • the extraction layer and the filter layer are preferably constructed in one to two layers.
  • the sample carrier card according to the invention has more than one sample application area, the individual sample application areas are attached separated by a seal. This seal prevents the samples from merging and mixing.
  • the sample carrier front card and / or the sample carrier return card can have readable information, which is preferably automatically readable. In this way, both secure handling and reliable detection of each sample to be analyzed in the automated, direct analysis method beyond doubt possible.
  • the readable information of the sample carrier front card and / or the sample carrier return card can be selected from at least one pictogram, at least one coding, such as at least one bar code, at least one information field, at least one free label field and / or a region for general information.
  • the invention further relates to a method for the direct analysis of samples by extraction of the sample from at least one sample carrier embedded in a sample carrier card, as described above, wherein the analysis of the sample is carried out in the flow.
  • the analysis is carried out in the flow in an HPLC analysis in an HPLC system.
  • the sample carrier can exercise a filter function in the context of HPLC analysis, which helps to eliminate annoying disturbing factors.
  • sample extraction can advantageously be carried out automatically.
  • FIG. 1 a view of the sample carrier front card
  • FIG. 2 a view of the sample carrier back card
  • FIG. 5a shows a view of the sample carrier front card before sampling
  • FIG. 5b shows a view of the sample carrier front card after the sampling.
  • the inventive sample carrier card designated overall by the reference numeral 1, has a sample carrier front card 3 and a sample carrier return card 5, which are formed similarly to a plastic credit card.
  • the aim of the sample carrier card 1 according to the invention is to be able to provide by means of this an automated sample extraction and measurement method which simultaneously avoids punching of the sample carrier 1 with the sample.
  • the sample carrier card 1 developed therefor is shown in front view and thus shows the sample carrier front card 3.
  • This has holes 7 which expose the sample application areas 9 of a sample carrier 11, which is inserted into the sample carrier card 1, and thus between the sample carrier front card 3 and the Sample carrier reversion card 5 is embedded.
  • the sample carrier 1 1 consists of at least two functional layers and is shown separately in FIG. 3.
  • the sample carrier 1 1 is constructed in two layers and on the one hand a layer 13 of a microfiber fabric and the second layer 15 has a PTFE filter coating.
  • these layers selected for the exemplary embodiment are to be seen by way of example and should not limit the sample carrier 1 with respect to the further possible layers.
  • the layers may also be formed from paper, cotton fibers and / or porous plastic, provided that they fulfill their fundamental function. This consists on the one hand in the extraction of the sample through the layer 13 (in this embodiment, the Mikxomaschinegewebe) and the filtering action of the second layer 15 (in this rougesbei play the PTFE filter coating).
  • one or both layers 13, 15 can be formed by more than one layer layer, preferably two layer layers, in order thus to enhance extraction and filtering action.
  • a maximum of four layers e.g. two of the extraction layer 13 and two of the filter layer 15 have been found to be very suitable.
  • the number of layer layers of each of the layers 13, 15 is also material-dependent.
  • the fundamental principle in the formation of layers is to provide a combination of layers which, with regard to the selected material properties of the layers 13, 15 or layer layers, the combination of a tough and a soft layer, so that on the one hand the task of extracting the sample and on the other hand, the task of filtering can be optimally perceived.
  • the extraction layer 13, the tough and the filter layer 15, the soft material property the soft material property.
  • a seal 17 is attached, which prevents samples from flowing into one another and mixing when applied to the microfibrous tissue 13 in the sample application area 9.
  • FIG. 2 shows the sample carrier return card 5 as the rear side of the sample carrier card 1, which likewise has holes 7 ', which in turn has the rear side of the sample carrier 11 uncover. If samples applied to the sample application areas 9 are to be extracted by means of this sample carrier card 1, the extraction medium used for each flows through the microfibrous tissue 13 of the sample carrier 11 and flows out through the PTFE filter coating 15.
  • the sample carrier front card 3 is provided with various information. These include a pictogram 21 and an information field 23, which, in particular for an automated measuring method, conveys which side is the sample application side and how large the sample quantity may be.
  • field 25 is provided in which a unique bar code is printed, and there are freely usable labeling fields 27 available.
  • the bar code in field 25 together with the individual details in the labeling fields 27 ensure the assignment of the samples and enable both automatic sample acquisition and the assignment of the analysis result.
  • an area 29 is provided.
  • the sample carrier card 1 is colored differently depending on the application area.
  • sample carrier return card 5 contains information in the form of a pictogram 31 and information and instructions for handling, which are printed in box 33.
  • the practical sample carrier card 1 i. the corresponding sample carrier front card 3 and sample carrier return card 5, reproduced in Figs. 4a and 4b.
  • Figures 5a and 5b show a sample carrier front card used for purposes of this embodiment prior to sampling and after sampling.
  • the sample carrier front card 3 in FIG. 5a designates the state before the sample application and the sample carrier front card 3 in FIG. 5b corresponding to the state after the sample application.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'invention concerne une carte de porte-échantillon intégrant un porte-échantillon (11) pour un procédé de mesure analytique, le porte-échantillon (11) destiné à loger directement un échantillon à mesurer présentant une structure au moins bicouche et comprenant au moins une couche d'extraction (13) et au moins une couche de filtration (15). Le porte-échantillon (1) est inséré dans une carte avant de porte-échantillon (3) et une carte arrière de porte-échantillon (5), respectivement en matière plastique, formant conjointement la carte de porte-échantillon (1). Le porte-échantillon (11) comprend plusieurs zones de chargement d'échantillon (9), les zones de chargement d'échantillon (9) individuelles étant séparées les unes des autres par une étanchéisation (17). La carte avant de porte-échantillon (3) et la carte arrière de porte-échantillon (5) comprennent respectivement au moins un évidement (7, 7'), le ou les évidements (7, 7') étant disposés respectivement au-dessus des zones de chargement d'échantillon (9) et dégageant celles-ci vers l'extérieur. L'invention concerne également un procédé d'analyse directe d'échantillons par extraction de l'échantillon d'au moins un porte-échantillon inséré dans la carte de porte-échantillon (1) précédemment mentionnée.
PCT/EP2012/001390 2011-03-29 2012-03-29 Carte de porte-échantillon et procédé d'extraction automatique et d'analyse directe d'échantillons WO2012130457A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12720784.3A EP2691765A1 (fr) 2011-03-29 2012-03-29 Carte de porte-échantillon et procédé d'extraction automatique et d'analyse directe d'échantillons

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00570/11A CH704757B1 (de) 2011-03-29 2011-03-29 Verfahren und Probenträgerkarte zur automatischen Extraktion und direkten Analyse von Proben.
CH00570/11 2011-03-29

Publications (1)

Publication Number Publication Date
WO2012130457A1 true WO2012130457A1 (fr) 2012-10-04

Family

ID=46084976

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/001390 WO2012130457A1 (fr) 2011-03-29 2012-03-29 Carte de porte-échantillon et procédé d'extraction automatique et d'analyse directe d'échantillons

Country Status (3)

Country Link
EP (1) EP2691765A1 (fr)
CH (1) CH704757B1 (fr)
WO (1) WO2012130457A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019106588A1 (fr) * 2017-12-01 2019-06-06 Copan Italia S.P.A. Support pour la conservation d'échantillons biologiques et procédé corrélé de production
EP3753634A1 (fr) * 2019-06-19 2020-12-23 Euroimmun Medizinische Labordiagnostika AG Support d'échantillon permettant de recevoir des composants sanguins séchés et procédé de récupération d'un élément membrane à l'aide des composants sanguins séchés

Citations (4)

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Publication number Priority date Publication date Assignee Title
WO1998002249A1 (fr) * 1996-07-17 1998-01-22 Robert William Cunningham Nouveau dispositif d'essai pour criblage de masse
US20020155034A1 (en) * 1999-12-23 2002-10-24 3M Innovative Properties Company Well-less filtration device
WO2011151083A2 (fr) 2010-06-04 2011-12-08 Doebelin Werner Procédé et dispositif d'analyse automatique et directe des échantillons de type « goutte séchée » au moyen d'un système lc-ms
EP2420831A1 (fr) * 2010-08-20 2012-02-22 Agilent Technologies, Inc. Dispositif et méthode pour éprouver des tâches de sang sèches

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US5612870A (en) * 1994-12-30 1997-03-18 Ortho Pharmaceutical Corporation System for tracking secure medical test cards
DE10020704B4 (de) * 2000-04-27 2006-09-28 Bioref Gmbh Biochip zur Archivierung und labormedizinischen Analyse von biologischem Probenmaterial, Verfahren zu dessen Herstellung sowie dessen Verwendung in diagnostischen Verfahren
US6474694B1 (en) * 2001-06-05 2002-11-05 Moore North America, Inc. Medical test form
EP1445021A1 (fr) * 2003-01-30 2004-08-11 Ferguson Davin Bradly Lame porteur pour échantillon de sang
WO2006081021A1 (fr) * 2005-01-25 2006-08-03 The Bode Technology Group, Inc Support de collecte de preuves pour traitement automatise d'echantillons

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002249A1 (fr) * 1996-07-17 1998-01-22 Robert William Cunningham Nouveau dispositif d'essai pour criblage de masse
US20020155034A1 (en) * 1999-12-23 2002-10-24 3M Innovative Properties Company Well-less filtration device
WO2011151083A2 (fr) 2010-06-04 2011-12-08 Doebelin Werner Procédé et dispositif d'analyse automatique et directe des échantillons de type « goutte séchée » au moyen d'un système lc-ms
EP2420831A1 (fr) * 2010-08-20 2012-02-22 Agilent Technologies, Inc. Dispositif et méthode pour éprouver des tâches de sang sèches

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RONALD E MAJORS: "New directions in whole blood analysis: Dried blood spot analysis and beyond", 1 January 2011 (2011-01-01), pages 1 - 15, XP002663447, Retrieved from the Internet <URL:http://chromatographyonline.findanalytichem.com/lcgc/Column%3A+Sample+Prep+Perspectives/New-Directions-in-Whole-Blood-Analysis/ArticleStandard/Article/detail/706364> [retrieved on 20111110] *
SANGEETA TANNA ET AL: "Analytical methods used in conjunction with dried blood spots", ANALYTICAL METHODS, ROYAL SOCIETY OF CHEMISTRY, GBR, vol. 3, no. 8, 1 January 2011 (2011-01-01), pages 1709 - 1718, XP009153957, ISSN: 1759-9660, DOI: 10.1039/C1AY05160A *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019106588A1 (fr) * 2017-12-01 2019-06-06 Copan Italia S.P.A. Support pour la conservation d'échantillons biologiques et procédé corrélé de production
CN111556788A (zh) * 2017-12-01 2020-08-18 意大利科潘恩集团公司 用于保存生物样品的支持物及相关生产方法
JP2021504700A (ja) * 2017-12-01 2021-02-15 コパン イタリア エス．ピー．エー． 生物学的サンプルの保存のための支持体および関連する製造方法
JP7332096B2 (ja) 2017-12-01 2023-08-23 コパン イタリア エス．ピー．エー． 生物学的サンプルの保存のための支持体および関連する製造方法
EP3753634A1 (fr) * 2019-06-19 2020-12-23 Euroimmun Medizinische Labordiagnostika AG Support d'échantillon permettant de recevoir des composants sanguins séchés et procédé de récupération d'un élément membrane à l'aide des composants sanguins séchés

Also Published As

Publication number Publication date
CH704757A1 (de) 2012-10-15
CH704757B1 (de) 2015-09-30
EP2691765A1 (fr) 2014-02-05

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