WO2012070577A1 - 軟カプセル皮膜 - Google Patents

軟カプセル皮膜 Download PDF

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Publication number
WO2012070577A1
WO2012070577A1 PCT/JP2011/076915 JP2011076915W WO2012070577A1 WO 2012070577 A1 WO2012070577 A1 WO 2012070577A1 JP 2011076915 W JP2011076915 W JP 2011076915W WO 2012070577 A1 WO2012070577 A1 WO 2012070577A1
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WIPO (PCT)
Prior art keywords
soft capsule
carrageenan
mass
starch
film
Prior art date
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Ceased
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PCT/JP2011/076915
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English (en)
French (fr)
Japanese (ja)
Inventor
加藤　健治
渡辺　和彦
井上　隆
幸司 増田
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Fuji Capsule Co Ltd
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Fuji Capsule Co Ltd
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Publication date
Application filed by Fuji Capsule Co Ltd filed Critical Fuji Capsule Co Ltd
Priority to JP2012527930A priority Critical patent/JP5149465B2/ja
Priority to KR1020127019689A priority patent/KR101401193B1/ko
Publication of WO2012070577A1 publication Critical patent/WO2012070577A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules

Definitions

  • the present invention relates to a soft capsule film and a method for producing a soft capsule using the same.
  • Soft capsules are used in a wide range of fields such as pharmaceuticals, foods, and cosmetics.
  • the most widely used soft capsule film base is gelatin, which is inexpensive and non-toxic, and exhibits excellent mechanical strength, film-forming ability, and the like.
  • a film-forming composition comprising a modified starch such as carrageenan, sodium octenyl succinate added with corn syrup solids, a plasticizer, and water.
  • Patent Document 1 Capsule skin composition containing carrageenan and dextrin (Patent Documents 2 and 3), acid-decomposed waxy corn starch, iota carrageenan and film forming composition for soft capsules containing plasticizer (Patent Document 4)
  • Patent Document 5 A coating composition containing hydroxypropylated dextrin, oxidized starch, gelling agent, plasticizer and water (Patent Document 5) has been reported.
  • soft capsule coatings require appropriate fluidity of the coating solution, good film formability, appropriate sheet strength / elongation / adhesiveness, etc. at the time of manufacture. Blocking resistance, elasticity, transparency and the like that prevent adhesion of the resin are required.
  • the actual situation is that a plant-based film having such film performance as a whole has not yet been found.
  • the present invention has been made in view of the conventional situation as described above, and has a good fluidity and film-forming property, and a vegetable soft capsule film and a method for producing soft capsules that provide excellent film performance. Relating to providing.
  • the present inventor when carrageenan and oxidized starch or bleached starch are combined, has an appropriate fluidity in the coating liquid, good film formability, and excellent coating. We found that performance was obtained. Furthermore, when soft capsules are produced from such a coating solution using a rotary die type soft capsule filling machine, the coating sheet is heated in advance and encapsulated by pressure bonding of the coating sheet without heat sealing. We have found that quality soft capsules can be produced continuously for a long time, and have completed the present invention.
  • a soft capsule film comprising (A) carrageenan, (B) oxidized starch and / or bleached starch, and (C) a plasticizer.
  • the carrageenan is a mixture of iota carrageenan and kappa carrageenan.
  • the soft capsule film as described. 3.
  • the content of iota carrageenan is 8 to 40% by mass in the total amount of solid components.
  • the content of iota carrageenan is 10 to 30% by mass in the total amount of solid components.
  • the soft capsule film as described. 5. 2.
  • the content of iota carrageenan is 15 to 20% by mass in the total amount of solid components.
  • the kappa carrageenan content is 0.1 to 0.8% by mass in the total amount of solid components. ⁇ 5.
  • the kappa carrageenan content is 0.3 to 0.8 mass% in the total amount of solid components. ⁇ 5.
  • the kappa carrageenan content is 0.4 to 0.7% by mass in the total amount of solid components. ⁇ 5.
  • the content ratio of iota carrageenan to kappa carrageenan is 400: 1 to 10: 1. ⁇ 8.
  • the mass ratio of iota carrageenan to kappa carrageenan is 133: 1 to 10: 1. ⁇ 8.
  • the mass ratio of iota carrageenan to kappa carrageenan is 75: 1 to 21: 1. ⁇ 8.
  • the content of oxidized starch and / or bleached starch is 60 to 90% by mass in the total amount of solid components. ⁇ 11.
  • the content of oxidized starch and / or bleached starch is 70 to 80% by mass in the total amount of solid components.
  • the above-mentioned 1. containing one or more standardized substances selected from the group consisting of sucrose, glucose, maltose, lactose and dextrin.
  • a method of manufacturing a soft capsule including a step of sending the pair of coating sheets between a pair of rotating molds, By heating to a temperature higher than room temperature while the pair of coating sheets reach a pair of rotating molds, the segment disposed on the upper part of the mold is heated to room temperature without heating.
  • a method for producing a soft capsule comprising capsule-molding a film sheet by pressure bonding. 16. 15. The coating sheet is heated by heating the rotating drum to 30 to 80 ° C.
  • the content of iota carrageenan is 15 to 20% by mass in the total amount of solid components.
  • the kappa carrageenan content is 0.1 to 0.8% by mass in the total amount of solid components. 21.
  • the kappa carrageenan content is 0.3 to 0.8% by mass in the total amount of solid components. 21.
  • the kappa carrageenan content is 0.4 to 0.7% by mass in the total amount of solid components. 21.
  • the mass ratio of iota carrageenan and kappa carrageenan is 400: 1 to 10: 1. 24.
  • the mass ratio of iota carrageenan to kappa carrageenan is 133: 1 to 10: 1. 24.
  • the above 18. wherein the mass ratio of iota carrageenan to kappa carrageenan is 75: 1 to 21: 1. 24.
  • the manufacturing method of the soft capsule in any one of. 28. (B)
  • the content of the oxidized starch and / or bleached starch is 60 to 90% by mass in the total amount of the solid components. 27.
  • the manufacturing method of the soft capsule in any one of. 29. (B) The above-mentioned 15., wherein the content of oxidized starch and / or bleached starch is 70 to 80% by mass in the total amount of solid components. 27. The manufacturing method of the soft capsule in any one of.
  • soft capsules excellent in film performance such as blocking resistance, elasticity and transparency can be stably provided without using animal-derived gelatin.
  • FIG. 1 is a diagram showing an example of a rotary die type soft capsule filling machine.
  • Carrageenan used in the present invention is a kind of galactan having a sulfate group, and is known to exist in red algae.
  • Carrageenans can be classified into three main types, iota carrageenan, kappa carrageenan, and lambda carrageenan, depending on the gelation characteristics and structure.
  • the Japanese food additive regulations stipulate three types: “refined carrageenan”, “processed Yukema algae”, and “Yukema algae powder” (published by “Japan Food Additives Association” These are only different in the degree of purification, and are essentially all included in the carrageenan of the present invention.
  • iota carrageenan and kappa carrageenan are preferably used from the viewpoint of gelation ability, and a mixture of iota carrageenan and kappa carrageenan is particularly preferable.
  • Each carrageenan may be a pure product or may contain a standardized substance.
  • a standardization substance 1 type, or 2 or more types selected from the group which consists of saccharides, such as sucrose, glucose, maltose, and lactose, and dextrin is mentioned. Sucrose and dextrin are preferred.
  • As the dextrin acid-decomposed dextrin and enzyme-degraded dextrin are preferable.
  • dextrin here is a different substance from maltodextrin ("degradation progressed more than dextrin" (Chemical Dictionary 8, page 897, Kyoritsu Shuppan)) and cyclic dextrin.
  • a blend raw material in which iota carrageenan and kappa carrageenan are mixed in advance can also be used.
  • the content of iota carrageenan is preferably 8 to 40% by mass, more preferably 10 to 30% by mass, and particularly preferably 15 to 20% by mass in the total amount of solid components from the viewpoint of film strength and fluidity of the film solution. % Is preferred.
  • the solid component refers to a film composition excluding purified water and a plasticizer.
  • the content of kappa carrageenan is preferably 0.1% by mass or more, more preferably 0.3% by mass or more in the total amount of solid components from the viewpoint of gelation strength, and the viewpoint of film strength (brittleness). To 0.8% by mass or less is preferable. More preferably, the content is 0.4 to 0.7% by mass.
  • the mass ratio of iota carrageenan and kappa carrageenan is 400: From a comprehensive viewpoint (film strength, fluidity of film solution, gel strength).
  • 1 to 10: 1 (40: 0.1 to 8: 0.8) is preferred, 133: 1 to 10: 1 (40: 0.3 to 8: 0.8) is more preferred, especially 75: 1 to 21: 1 (30: 0.4 to 15: 0.7) is preferred.
  • the (B) oxidized starch used in the present invention is a starch obtained by oxidizing starch with an oxidizing agent. It should be noted that self-modified starch obtained by reducing the viscosity of the starch by thermochemical treatment with an acid, an oxidizing agent, or the like is also included in the oxidized starch.
  • the oxidized starch is preferably not subjected to chemical treatment other than oxidation treatment, for example, acid treatment, pregelatinization, etherification, acetylation or the like. As a result of examination, it has been found that starch subjected to acetylation is not suitable (Test Example 13 described later).
  • the (B) bleached starch used in the present invention is a starch in which the color tone of the starch is adjusted by oxidizing other pigment components without chemically modifying the starch.
  • each of oxidized starch and bleached starch may be used alone, or two or more of oxidized starch and bleached starch may be appropriately mixed and used.
  • starch that is subjected to oxidation treatment or the like
  • examples thereof include unmodified starches such as corn starch, waxy corn starch, tapioca starch, potato starch, sweet potato starch, and wheat starch. Of these, a mixture of two or more starches may be oxidized.
  • the oxidizing agent is not particularly limited.
  • alkali metal hypochlorite such as sodium hypochlorite
  • alkaline earth metal hypochlorite such as calcium hypochlorite
  • sodium chlorite examples include alkali metal chlorites such as potassium chlorate; alkaline earth metal chlorites such as barium chlorite.
  • the content of (B) oxidized starch and / or bleached starch is preferably 90% by mass or less in the total amount of solid components and 60% by mass or more in terms of adhesive strength, from the viewpoint of film sheet strength. More preferable is 80 mass%.
  • the (C) plasticizer used in the present invention is not particularly limited, and examples thereof include glycerin, sorbitol, propylene glycol, and polyethylene glycol. Of these, glycerin is preferable. From the viewpoint of flexibility, the plasticizer in the soft capsule film is preferably contained in an amount of 30 to 60 parts by mass, particularly 40 to 50 parts by mass, with the total amount of solid components being 100 parts by mass.
  • various additives used for the capsule film for example, natural dyes, synthetic dyes, shading agents, various sweeteners and other flavoring agents, preservatives, stabilizers, A water activity reducing agent, a pH adjusting agent, etc. can be mix
  • the soft capsule film of the present invention may contain, as needed, gelling agents other than carrageenan such as sodium alginate, pullulan, glucomannan, gum arabic, and fercellan; unmodified starch, modified starch, starch degradation product, etc.
  • gelling agents other than carrageenan such as sodium alginate, pullulan, glucomannan, gum arabic, and fercellan
  • unmodified starch modified starch, starch degradation product, etc.
  • Oxidized starch and starches other than bleached starch can be included, but considering the physical properties of the film and the quality of the soft capsule, the content of gelling agents other than carrageenan and starches other than oxidized starch and bleached starch are preferably 1% by mass or less, more preferably 0.5% by mass or less, and particularly preferably 0% by mass in the total amount of solid components.
  • the soft capsule film can be produced according to a conventional method.
  • carrageenan, oxidized starch and / or bleached starch, plasticizer, and if necessary, various additives may be stirred and dispersed in water, stirred and dissolved at 90 to 98 ° C., and then vacuum degassed.
  • the pH of the coating solution (100-fold diluted solution, 70 ° C.) is preferably 6.0 to 8.0.
  • a soft capsule can be obtained by forming such a soft capsule film into a predetermined shape and drying it.
  • the soft capsule can be produced, for example, by a conventionally used method for producing a soft capsule, for example, a punching method using a rotary die type soft capsule filling machine, a flat plate method, or the like. Especially, it is preferable to manufacture by a rotary die type from the point of industrial productivity.
  • the rotary die type soft capsule filling machine is a method of punching two coated sheets formed by spreading a soft capsule coating solution on a rotating drum into a capsule shape with a pair of rotating molds (die rolls). Molding and filling of the capsule contents are performed simultaneously.
  • FIG. 1 shows an example of a rotary die type soft capsule filling machine used in the present invention.
  • the rotary die type soft capsule filling machine 10 mainly includes a rotating drum 13, a pair of rotating molds (die rolls) 16, and a segment 17.
  • the soft capsule coating solution is supplied from the tank 11 and spread on the rotating drum 13 by the casting device 12 to form the coating sheet A.
  • a pair of coating sheets A are formed.
  • the pair of coating sheets A is fed between a pair of rotating molds (die rolls) 16 via a lubricating roller 14 and a deflecting roll 15, and on the other hand, a piston of a pump 18 interlocked with the mold (die roll) 16.
  • Capsule contents B which 18A is pumped are press-fitted between coating sheets A which are sandwiched between molds (die rolls) 16 and meet each other.
  • the coating sheet A is provided with a recess by the recess 16A of the mold (die roll) 16, and is pressed around the recess by the periphery of the recess 16A.
  • the capsule content B is pressed into the indentation.
  • the recess is completely closed by the periphery of the recess 16 ⁇ / b> A to form a soft capsule, and the soft capsule C is punched out by pressure cutting of the die (die roll) 16.
  • the soft capsule coating solution is spread on a pair of cooled rotating drums to form a pair of sheets, and at the time of capsule formation, the soft capsule coating liquid is disposed on top of a pair of rotating molds (die rolls) 16.
  • the pair of coated sheets is heated to a temperature required for bonding (usually 40 ° C. or higher) by the segment 17, and a soft capsule having a completely bonded surface is formed by the pressure of the die roll and heat sealing.
  • the pair of film sheets is heated to a temperature higher than room temperature, for example, 30 to 80 ° C., preferably After heating to 40 to 75 ° C., it is preferably sent between a pair of rotating molds (die rolls) and the film is capsule-formed by pressure bonding at room temperature (22 to 28 ° C.) without heating the segments. .
  • room temperature 22 to 28 ° C.
  • the coating sheet is heated by, for example, a method of heating the rotating drum to 30 to 80 ° C., preferably 40 to 75 ° C., and a heating device such as blowing an infrared heater or hot air between the rotating drum and the mold. It is performed by the method of heating.
  • the coating sheet should just be heated to temperature higher than normal temperature from shaping
  • the soft capsule of the present invention can be used for various uses such as pharmaceuticals, quasi drugs, foods, and cosmetics, and the composition of the capsule contents is appropriately determined according to the use.
  • the content may be in the form of a solution, a suspension, a paste, a powder, a granule or the like.
  • a soft capsule is packaged and preserve
  • Iota carrageenan CP Kerco's standardized substance (sucrose) added at 20% by mass. * Kappa carrageenan: 100% by mass manufactured by Mitsubishi Corporation Foodtech. Oxidized starch: “Stabilose” manufactured by Matsutani Chemical Co., Ltd., carboxy group content of 0.8% by mass or less Glycerin: Food additive grade manufactured by Sakamoto Pharmaceutical Co., Ltd. * Each of “Iota Carrageenan” described in the prescription column of each test example The prescription amount described is the amount not containing the standardized substance.
  • Example 1 Production of soft capsules by flat plate method
  • Production method A The gelling agent, starch, and glycerin in the amounts (parts by mass) shown in Table 1 were each stirred and dispersed in water, then dissolved with stirring at 90 to 95 ° C., and vacuum degassed.
  • the coating solution is spread evenly on a stainless steel plate to a thickness of about 1 mm using a thin-layer chromatographic applicator and cooled at about 15 ° C. for 2 minutes to obtain a film-like coating sheet. It was. (At this stage, the following [a. Evaluation of strength of coating sheet] [b. Evaluation of elongation of coating sheet] was performed.
  • the obtained coated sheet was encapsulated using a flat simple capsule device while the mold was warmed to form soft capsules (Test Examples 1 to 6). (At this stage, [c. Evaluation of Adhesiveness of Film Sheet Immediately after Capsule Molding] was performed.)
  • this soft capsule was stored in a desiccator adjusted to a relative humidity of 20% or less for 24 hours to obtain a dry soft capsule. (At this stage, [d. Evaluation of elasticity of capsule after drying], [e. Evaluation of adhesion of capsule after drying] and [f. Evaluation of transparency of capsule after drying] were performed. ) In this test, it is assumed that the coating sheet is cooled on the rotating drum and heating is performed in the segments, as in the conventional case.
  • this soft capsule was stored in a desiccator adjusted to a relative humidity of 20% or less for 24 hours to obtain a dry soft capsule. (At this stage, [d. Evaluation of elasticity of capsule after drying], [e. Evaluation of adhesion of capsule after drying] and [f. Evaluation of transparency of capsule after drying] were performed. ) In this test, it is assumed that the coating sheet is heated on the rotating drum and that the segment is performed at room temperature.
  • the soft capsule film of the present invention was excellent in film performance and was able to obtain soft capsules with good quality (Test Examples 1 and 2).
  • Test Examples 3 to 6 using starch other than oxidized starch and Test Example 7 using native gellan gum as a gelling agent the physical properties of the film were difficult, and the elasticity and adhesion after encapsulation were poor. .
  • Example 2 Production of Soft Capsule by Rotary Die Type Soft Capsule Filling Machine (1) After stirring and dispersing each amount of carrageenan, starch and glycerin shown in Table 2 in water, at 90 to 98 ° C. It was dissolved with stirring and degassed in vacuo. Soft capsules were produced from this coating solution using a rotary die type soft capsule filling machine 10 shown in FIG. First, the coating liquid was spread on a rotating drum at 45 ° C. by a casting apparatus to prepare a coating sheet. The temperature of the film sheet at this time was 45 ° C. The physical properties (strength, elongation, adhesion) of each coating sheet were evaluated in the same manner as in Example 1.
  • membrane of this invention was excellent in film
  • Test Examples 9-11 and 16 using unmodified starch and the like the viscosity of the coating liquid was high, the mechanical strength was insufficient, and encapsulation was not possible.
  • Test Example 13 using acetylated oxidized starch the pH of the coating solution was low and could not be encapsulated.
  • Test Examples 12, 14-15, and 17-18 using acid-treated waxy corn starch and the like there is particularly difficulty in the elongation and adhesion of the film, and the elasticity and adhesion after encapsulation are inferior. It was not enough.
  • Example 3 (1) In the same manner as in Example 2, a coating solution was prepared according to the formulation shown in Table 3, and then a coating sheet was prepared using a rotary die type soft capsule filling machine 10. The physical properties (strength, elongation, adhesion) of each coating sheet were evaluated in the same manner as in Example 1.
  • Example 2 Soft capsules were continuously produced for 120 minutes from the obtained two coated sheets in the same manner as in Example 2 (Test Examples 20 to 25). The temperature of the coating sheet near the rotating mold was about 29 ° C. The elasticity, adhesion, and transparency of the soft capsule were evaluated in the same manner as in Example 1. The results are shown in Table 3.
  • the soft capsule film of the present invention was excellent in film performance and was able to obtain a soft capsule with good quality (Test Examples 19-24). Further, it was confirmed that no problem occurred even in continuous operation for 120 minutes, and that soft capsules could be stably produced for a long time.
  • Example 4 The following materials were used. Iota carrageenan: CP Kerco's standardized substance (sucrose) added at 40% by mass. * ⁇ : MSC standardized substance (dextrin) 40% by mass added product. * Kappa carrageenan: 100% by mass manufactured by Mitsubishi Corporation Foodtech. Oxidized starch: “Stabilose” manufactured by Matsutani Chemical Co., Ltd., carboxy group content of 0.8% by mass or less Glycerin: Food additive grade manufactured by Sakamoto Pharmaceutical Co., Ltd. * Each of “Iota Carrageenan” described in the prescription column of each test example The prescription amount described is the amount not containing the standardized substance.
  • Example 1 (1) In the same manner as in Production Method B of Example 1, a film solution was prepared according to the formulation shown in Table 4 to obtain a film-shaped film sheet. The physical properties (strength and elongation) of each coating sheet were evaluated in the same manner as in Example 1.
  • the soft capsule film of the present invention was excellent in film performance and was able to obtain soft capsules of good quality (Test Examples 25, 26, 31 to 32).
  • Test Example 27 using unmodified starch, the viscosity of the coating liquid was high, the mechanical strength was insufficient, and encapsulation was not possible.
  • Test Examples 28 to 30 using acid-treated waxy corn starch or the like, it was particularly difficult to stretch the film, and the quality of the soft capsule was not sufficient.
  • Rotary die type soft capsule filling machine 10
  • Tank 11 Casting device 12
  • Rotating drum 13 Lubrication roller 14
  • Deflection roll 15 A pair of rotating molds (die rolls) 16 Mold (die roll) recess 16A Segment 17
  • Soft capsule C Soft capsule C

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PCT/JP2011/076915 2010-11-22 2011-11-22 軟カプセル皮膜 Ceased WO2012070577A1 (ja)

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CN104161214A (zh) * 2013-10-31 2014-11-26 上海新农饲料股份有限公司 一种耐高温储运乳猪颗粒状饲料及其制备方法
US20150119472A1 (en) * 2013-10-26 2015-04-30 Zhongshan Capsule Starch Material Technology Co., Ltd. Mixing and extruding method for preparing starch softgel capsules
JP2017105767A (ja) * 2015-12-03 2017-06-15 大正製薬株式会社 カプセル組成物
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JP2021510154A (ja) * 2018-01-10 2021-04-15 シーピー ケルコ エイピーエス フィルムおよびカプセル用のカラギーナンベースの組成物

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