WO2012070111A1 - 測定システム、測定方法、前記方法を実施するためのプログラム、およびこのプログラムの記録媒体 - Google Patents
測定システム、測定方法、前記方法を実施するためのプログラム、およびこのプログラムの記録媒体 Download PDFInfo
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- WO2012070111A1 WO2012070111A1 PCT/JP2010/070846 JP2010070846W WO2012070111A1 WO 2012070111 A1 WO2012070111 A1 WO 2012070111A1 JP 2010070846 W JP2010070846 W JP 2010070846W WO 2012070111 A1 WO2012070111 A1 WO 2012070111A1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00108—Test strips, e.g. paper
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00148—Test cards, e.g. Biomerieux or McDonnel multiwell test cards
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00613—Quality control
- G01N35/00663—Quality control of consumables
- G01N2035/00673—Quality control of consumables of reagents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00742—Type of codes
- G01N2035/00752—Type of codes bar codes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00792—Type of components bearing the codes, other than sample carriers
- G01N2035/00811—Type of components bearing the codes, other than sample carriers consumable or exchangeable components other than sample carriers, e.g. detectors, flow cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N2035/00891—Displaying information to the operator
Definitions
- the present invention reacts a sample to be measured with a reagent using a measuring tool such as a biosensor, urine test paper, or immunochromatographic test strip, and changes in current value, potential difference, or color tone appearing on the surface or inside of the test strip.
- a measuring tool such as a biosensor, urine test paper, or immunochromatographic test strip
- the present invention relates to a measurement system, a measurement method, a program for executing the method, and a recording medium for the program.
- Patent Documents 1 to 3 and the like have been introduced in detail about methods for measuring body fluid components such as humans and animals using simple measuring tools.
- Patent Document 1 describes a test piece in which one or more reagent layers impregnated with a chemical reaction reagent are attached to a strip-shaped plastic support at regular intervals.
- Patent Document 2 describes an immunochromatographic test piece and a measurement method using the same. As the immunochromatographic test piece, one using colloidal gold particles, blue latex particles, or red latex particles as a label carrier is generally used.
- Patent Document 3 describes a test piece having an electrode and an oxidoreductase on a support. This test piece measures an electrochemical change (oxidation current value) during an enzyme reaction. According to these test pieces, body fluid components such as humans and animals can be easily measured.
- Patent Document 4 A system that overcomes this problem is described in Patent Document 4.
- the system described in Patent Literature 4 is provided with a plurality of loading portions for measuring tools. For each loading unit, measurement is performed individually and automatically after the measurement tool is loaded until the reaction time corresponding to the type of reagent elapses, and the result is displayed. As a result, a plurality of specimens can be measured simultaneously and randomly.
- JP-A-5-232108 Japanese Patent Publication No. 7-46107 JP-A-1-114747 JP 2009-13381 A
- the user can confirm the information of the sample provider, and the measurement tool to which the sample from the sample provider is applied, It was necessary to perform an operation of confirming which of the plurality of loading units was loaded, and to associate the obtained measurement result with the information of the sample provider. Such work is troublesome for the user.
- the present invention has been conceived under such circumstances, and even if the measurement system has a plurality of loading sections and can measure a plurality of specimens simultaneously and randomly, the present invention can be obtained. It is an object of the present invention to provide a measurement system, a measurement method, a program for implementing the method, and a recording medium for the program that can easily associate the measured results with the information of the sample provider.
- the present invention takes the following technical means.
- a measurement system provided by the first aspect of the present invention is a measurement system including a plurality of loading units loaded with a measurement tool that holds a reagent, for reading information on a sample provider including identification information
- the reading device and the measurement tool to which the sample from the sample provider is applied are selected from the plurality of loading sections and individually read to the sample provider by the identification information read by the reading unit.
- Guidance means for guiding to the associated loading section.
- the guiding means is a plurality of indicator lamps arranged to correspond to each of the plurality of loading sections, and the indicator lamp performs guidance by turning on, turning off, or changing color.
- the guiding means is blocking means for blocking loading of the measurement tool into another loading unit other than the loading unit individually associated with the specimen provider.
- each of the plurality of loading units includes an opening for loading the measurement tool, and the blocking unit closes the opening of the other loading unit.
- the guiding means is a display device that displays position information of the loading unit individually associated with the sample provider.
- the display device is at least one of a display, a printer, and a voice guidance device.
- the information of the sample provider is recorded as a barcode
- the reading means is at least one of a barcode reader and an image recognition camera.
- the reading unit includes a touch panel, and the information of the sample provider is displayed in advance on the touch panel, and specific information is selected from the information displayed on the touch panel as a user. Touch to select.
- each of the plurality of loading units includes a sensor capable of recognizing that the measurement tool is loaded in the back.
- the measurement tool to which the sample derived from the sample provider specified by the information read by the reading unit is applied is a loading other than the loading unit individually associated with the sample provider.
- a warning means for warning that the measurement tool has been loaded in error when the sensor detects that the measurement tool has been loaded is a warning means for warning that the measurement tool has been loaded in error when the sensor detects that the measurement tool has been loaded.
- the measurement method provided by the second aspect of the present invention is a measurement method using a measurement system including a plurality of loading units loaded with measurement tools for holding a reagent, and includes information on a specimen provider including identification information.
- a reading unit by the reading means, and a loading unit for loading the measurement tool to which the sample from the sample provider is applied is selected from the plurality of loading units, and the loading unit is identified.
- the detecting means includes: a step of guiding by the means; a step of detecting by the detecting means that the measurement tool has been loaded into the loading section; Triggered by the measuring instrument detects that it has been loaded into the loading portion comprises a step of starting the measurement of the measuring instrument by measuring means.
- the information read by the step of calculating the measurement result based on the data obtained by the measurement, and the step of reading the information of the specimen provider is the measurement result obtained by the step of calculating the measurement result. And a step of outputting by the output device.
- a program provided by the third aspect of the present invention is a program for causing a computer to perform operation control of a measurement system including a plurality of loading units loaded with a measurement tool that holds a reagent.
- a step of reading information of a sample provider including a reading unit; and a loading unit for loading the measurement tool to which the sample from the sample provider is applied is selected from the plurality of loading units; and The loading unit is individually associated with the sample provider by the identification information, and the measurement tool to which the sample derived from the sample provider is applied is individually associated with the sample provider.
- the information read by the step of calculating the measurement result based on the data obtained by the measurement, and the step of reading the information of the specimen provider is the measurement result obtained by the step of calculating the measurement result.
- the step of outputting by the output device is further executed by the computer.
- the detection unit detects that the measurement tool has been removed from the loading unit, and the loading unit is used as a new measurement tool in response to the detection unit being removed from the loading unit. And causing the computer to further execute the step of making the state acceptable.
- the computer-readable recording medium provided by the fourth aspect of the present invention records a program to be executed by the computer provided by the third aspect of the present invention.
- FIG. 1 is an overall perspective view showing an example of a measurement system according to the present invention.
- FIG. 2 is a block diagram showing the relationship between the components in the measurement system shown in FIG.
- FIG. 3 is a perspective view showing a state in which the measurement system shown in FIG. 1 reads the information of the sample provider.
- FIG. 4 is a perspective view showing a state in which the measurement system shown in FIG. 1 induces loading of a test piece.
- FIG. 5 is a perspective view showing a state where the measurement system shown in FIG. 1 is measuring a test piece.
- FIG. 6 is a perspective view showing a state in which the measurement system shown in FIG. 1 displays measurement results.
- FIG. 7 is a flowchart showing a part of an example of an operation processing procedure in the measurement system shown in FIG. FIG.
- FIG. 8 is a flowchart showing a part of an example of an operation processing procedure in the measurement system shown in FIG.
- FIG. 9 is an overall perspective view showing another example of the measurement system according to the present invention.
- FIG. 10 is an overall perspective view showing another example of the measurement system according to the present invention.
- FIG. 11 is an overall perspective view showing another example of the measurement system according to the present invention.
- FIG. 12 is an overall perspective view showing another example of the measurement system according to the present invention.
- FIG. 13 is a block diagram showing another example of the measurement system according to the present invention.
- a measurement system MS1 shown in FIG. 1 uses an immunochromatographic test piece 4 as a measurement tool, and is installed in a hospital or the like.
- the measurement system MS1 is a measurement system that can simultaneously and randomly measure specimens derived from a plurality of patients.
- the measurement system MS1 includes a measurement device 1 and a barcode reader 2.
- the measuring device 1 and the barcode reader 2 are connected by a cable 21.
- the cable 21 is in a wired form in the figure, it may of course be in a wireless form.
- the bar code reader 2 corresponds to an example of a reading unit referred to in the present invention.
- An image recognition camera can also be used as the reading means.
- the bar code reader 2 is for reading a bar code 3 on which patient information such as identification information (ID), which is affixed to a patient chart or sample collection container, is recorded.
- patient information may include information such as the name of a disease or the name of a drug being administered, in addition to identification information such as an ID number or name.
- ID identification information
- a patient corresponds to an example of a sample provider in the present invention.
- “specimen provider information including identification information” includes not only the case where the sample provider information includes both identification information and information other than the identification information, but also includes only the identification information. Including the case.
- the measurement system MS1 uses the immunochromatographic test piece 4 as a measurement tool.
- the immunochromatographic test piece 4 is for performing an influenza test, for example.
- the immunochromatographic test piece 4 has a case 40, and a support 42a holding a reagent is accommodated in the case.
- the case 40 includes a handle 44, a specimen dropping window 41, a measurement window 42, and an item identification barcode 43.
- the user holds the handle 44 and loads the immunochromatographic test piece 4 into the loading unit 10 according to the instruction of the guiding means of the measurement system MS1.
- the measurement system MS1 recognizes the measurement item of the immunochromatographic test piece 4 by reading the item identification barcode 43.
- the user collects the liquid on the mucous membrane of the patient's pharynx or nasal cavity using a cotton swab or the like, and drops the sample diluted with the diluent onto the sample dropping window 41.
- the dropping of the specimen may be performed before the immunochromatographic test piece 4 is loaded in the loading unit 10 or after the loading.
- the dropped specimen moves on the support by a chromatographic phenomenon.
- the line 42b on the support 42a contains an anti-influenza virus antibody colored with colloidal gold, red latex particles, or blue latex particles.
- influenza virus When influenza virus is present in the sample, the influenza virus in the sample binds to this antibody, moves due to a chromatographic phenomenon, and is trapped by the anti-influenza virus antibody immobilized on the line 42c.
- a color to be measured is generated on the line 42c.
- the sample is applied to the measurement tool by application, suction, immersion, or the like in addition to dropping, depending on the type of the measurement tool.
- the measuring device 1 includes a main body case 18.
- the main body case 18 has a rectangular shape, is formed of, for example, resin or metal, and houses a plurality of loading units 10 that are other components of the measurement system. An opening for inserting a test piece into the loading unit 10 is formed on the front surface of the main body case 18.
- the measuring apparatus 1 includes a plurality of loading units 10 and a plurality of indicator lamps 11 corresponding to them.
- the measurement apparatus 1 includes three-channel loading units 10a, 10b, and 10c.
- the loading unit 10 is for loading the immunochromatographic test piece 4 and performing measurement.
- Each loading part 10a, 10b, 10c is provided with an opening 10A for loading the immunochromatographic test piece 4.
- the opening 10 ⁇ / b> A is arranged so as to coincide with the position of the opening formed on the front surface of the main body case 18.
- Each of the loading sections 10a, 10b, and 10c can perform measurement independently, and can load three immunochromatographic test pieces 4 at arbitrary timing to start measurement and obtain a measurement result.
- loading means that the component in the sample applied to the measurement tool can be measured by inserting or placing the measurement tool in the loading unit 10.
- Each indicator lamp 11a, 11b, 11c is arranged so as to correspond to each loading section 10a, 10b, 10c.
- the indicator lamp 11 is composed of, for example, an LED lamp.
- the indicator lamp 11 corresponds to an example of the guiding means in the present invention.
- the indicator lamp 11 is used to guide the user to load the immunochromatographic test strip 4 into the loading section 10 selected so as to correspond to the patient identification information read by the barcode reader 2. is there. Thereby, the patient's identification information and the immunochromatographic test piece 4 to which the patient-derived specimen is dropped are associated.
- the indicator lamp 11 guides the user by turning on or off, or changing the color.
- the above-mentioned “lighting” does not mean that, for example, two of the three indicator lamps 11 are turned off and one of them is turned on. It also includes guiding to the loading unit 10 corresponding to the indicator lamp 11 that is extinguished by turning on two and extinguishing one. Further, it includes not only turning on or off the arbitrary indicator lamp 11 continuously but also blinking. Moreover, the quantity of the loading part 10 and the indicator lamp 11 is not restricted to three pieces, It can also be made into two to ten pieces.
- the display 14 and the printer 13 are arranged on the upper surface of the main body case 18 of the measuring apparatus 1.
- the display 14 is for displaying the patient information, measurement items, measurement results, and the like corresponding to the loading units 10a, 10b, and 10c in association with each other.
- a liquid crystal display (LCD) is used as the display 14.
- the printer 13 is for associating and outputting patient information and measurement results.
- the printer 13 and the display 14 are display devices and have a function as warning means.
- a speaker 15 is disposed on the side surface of the main body case 18 of the measuring apparatus 1.
- the speaker 15 is used to emit a warning sound when the user makes a mistake in the loading position of the immunochromatographic test piece 4 or when the user forgets to remove the immunochromatographic test piece 4 that has been measured.
- the speaker 15 corresponds to an example of a voice guidance device according to the present invention.
- the measuring device 1 includes a control unit 17 and an area sensor 16 in addition to the loading unit 10, the indicator lamp 11, the display 14, the printer 13, and the speaker 15 described above.
- a sensor 12 is incorporated in the loading unit 10.
- the control unit 17 is for controlling the operation process of the measurement system MS1.
- the control unit 17 includes a microcomputer (hereinafter referred to as CPU) 17a and a memory 17b.
- the CPU 17a is connected to the barcode reader 2, the indicator lamp 11, the display 14, the printer 13, the speaker 15, the area sensor 16, and the sensor 12 through control lines.
- the CPU 17a controls the operation process of the measurement system MS1 by executing a program stored in the memory 17b. Further, the CPU 17a calculates a measurement result based on the data acquired by the area sensor 16.
- An interface circuit is disposed between these components and the CPU 17a as necessary.
- the memory 17b includes a ROM area and a RAM area.
- the ROM area stores an operation processing program and parameters of the measurement system MS1. In addition to the operation processing program, the RAM area temporarily stores patient information read by the barcode reader 2 and data acquired by the area sensor 16.
- the sensor 12 is disposed in each inner part of the loading unit 10 and detects that the immunochromatographic test piece 4 has been loaded in the loading unit 10.
- the sensor 12 corresponds to an example of the detection means referred to in the present invention.
- a mechanical sensor is used as the sensor 12.
- an optical sensor including a light emitting module and a light receiving sensor module can be used in addition to a mechanical sensor.
- the area sensor 16 used for optical measurement can also be configured to serve as the optical sensor.
- the area sensor 16 is provided so as to be movable above the loading unit 10 in the direction of arrow N1.
- the area sensor 16 corresponds to an example of the measuring means in the present invention.
- the area sensor 16 moves above the loading unit 10.
- the area sensor 16 first reads the barcode 43 in which the measurement items of the immunochromatographic test piece 4 are recorded.
- the area sensor 16 reads the color change of the line 42c that appears in the measurement window 42 as image data.
- the area sensor 16 is suitable for detecting a belt-like coloration such as a line 42c generated on the surface of the support 42a.
- FIG. 3 shows a state in which the measurement system MS1 reads patient information.
- the barcode 3 on which the patient information including the identification information pasted on the patient's chart is recorded is read by the barcode reader 2 (S1).
- the patient information including the read identification information is stored in the memory 17b in the measuring apparatus 1 (S2).
- the control unit 17 selects, for example, the loading unit 10a from among the unused loading units 10 according to a predetermined rule (S3). When selecting the loading unit 10, a plurality of loading units 10 may be selected so that the user can arbitrarily select the loading unit.
- the control unit 17 stores the selected loading unit 10a and the patient information including the identification information stored in the memory 17b in association with each other (S4). Thereby, the patient who is the sample provider is associated with the loading unit 10a.
- the patient identification information is, for example, a patient ID number or a patient name.
- FIG. 4 shows a state in which the measurement system MS1 induces loading of the immunochromatographic test piece 4.
- the indicator lamp 11a selects the immunochromatographic test piece 4 to which the patient sample is applied, as shown in FIG. It guide
- the guidance is performed by blinking the indicator lamp 11a provided corresponding to the selected loading unit 10a.
- the induction process is continuously performed (S6: NO, S5).
- the immunochromatographic test strip 4 When the immunochromatographic test strip 4 is loaded into any of the loading sections 10 through the opening 10A, it is determined whether or not the immunochromatographic test strip 4 is correctly loaded at the location indicated by the indicator lamp 11a (S7). . The determination is made using the sensor 12 installed in the back of the loading unit 10. When a signal indicating that the immunochromatographic test piece 4 has entered is output by the sensors 12b and 12c of the loading portions 10b and 10c different from the place indicated by the indicator lamp 11a, the warning light is emitted from the speaker 15 and used. A process of notifying the person of the fact that the person is wrong (S8: NO, S17) and a check for reloading are performed (S18).
- the means for notifying the error is not limited to the method of emitting a warning sound from the speaker 15. It is also possible to display an error such as “NG” on the output of the display 14 or the printer 13 or to change the color of the indicator lamp 11a or blink. If reloading is not performed, a warning sound is continuously emitted from the speaker 15 (S19: NO, S17). If reloaded, the loading position is checked again (S19: YES, S7).
- the control unit 17 determines that the immunochromatographic test piece 4 is loaded correctly. Then, the indicator lamp 11a changes to continuous lighting (S8: YES, S9).
- FIG. 5 shows a state in which the measurement system MS1 measures the immunochromatographic test piece 4.
- the area sensor 16 moves above the loading unit 10a and reads the item identification barcode 43 provided on the case 40 of the immunochromatographic test piece 4 (S10).
- the immunochromatographic test piece 4 is measured (S11).
- the image data of the line 42c on the support 42a is acquired by the area sensor 16. Is done.
- the acquired data is sent to the control unit 17.
- the control unit 17 Based on the calibration curve stored in the memory 17b, the control unit 17 calculates the amount of influenza virus that is a measurement object as a measurement result.
- FIG. 6 shows a state in which the measurement system MS1 displays the measurement result.
- the printer 13 prints the measurement date and time, the patient information including the identification information, and the measurement result on the printing paper 13a (S12).
- the measurement result is sent to a host computer such as a personal computer.
- the control part 17 changes lighting of the indicator lamp 11a from continuous lighting to light extinction (S13).
- the measurement system MS1 includes a plurality of loading units 10 that can perform measurement independently, even if the measurement of one loading unit 10 (for example, the loading unit 10a) is not completed, another loading unit 10 10 (for example, the loading unit 10b or 10c) can be started, and the measurement results can be obtained individually.
- one loading unit 10 for example, the loading unit 10a
- another loading unit 10 10 for example, the loading unit 10b or 10c
- the measurement system MS1 turns on the indicator lamp (11a in the present embodiment) to turn on the dedicated light individually corresponding to the patient based on the patient identification information read by the barcode reader 2.
- the immunochromatographic test piece 4 to which the specimen derived from the patient (specimen provider) is applied is guided to the loading section 10a. Therefore, the user of the present measurement system MS1 loads the immunochromatographic test strip 4 to the corresponding dedicated loading section 10a without memorizing the patient ID and the loading location by himself / herself according to the guidance by turning on the indicator lamp 11a. I can do it. Thereby, the user can easily associate the patient information including the identification information specified by reading with the barcode reader 2 and the measurement result obtained from the patient-derived specimen. In addition, the certainty of this association can be improved.
- the above flow can be executed simultaneously and randomly for each of the loading units 10a, 10b, 10c.
- the user can use the patient information including the identification information specified by reading by the barcode reader 2 and the samples from the patients. It is possible to easily relate the obtained measurement results. In addition, the certainty of this association can be improved.
- the measurement apparatus 1A included in the measurement system MS2 has three loading units 10 as in the above embodiment, and includes a shutter 10S in addition to the indicator lamp 11. Yes.
- the indicator lamp 10 guides to the dedicated loading unit selected by lighting, as in the above embodiment.
- the shutter 10S is configured to prevent loading of the immunochromatographic test strip 4 to which the specified patient-derived specimen is applied to the loading units 10b and 10c different from the selected dedicated loading unit 10a. Yes. That is, when the user reads patient information including the identification information recorded in the barcode 3 using the barcode reader 2, the dedicated loading unit 10a selected to correspond to the read identification information
- the shutter 10S is lowered to close the opening 10A of the unloading portions 10b and 10c.
- the immunochromatographic test strip 4 to which the specified patient-derived specimen is applied is guided to the dedicated loading unit 10a.
- the user can easily associate the patient information identified by reading with the barcode reader 2 with the measurement result obtained from the patient-derived specimen.
- the certainty of this association can be improved.
- the measurement apparatus 1B included in the measurement system MS3 includes a block 10B instead of the shutter 10S of the embodiment shown in FIG.
- the block 10B blocks the opening 10A of the loading units 10b and 10c that are not the loading unit 10a so as to prevent loading of the immunochromatographic test strip 4 into the loading units 10b and 10c different from the selected dedicated loading unit 10a. It is comprised so that it may protrude. Thereby, the user can easily associate the patient information specified by reading with the barcode reader 2 with the measurement result obtained from the patient-derived specimen. In addition, the certainty of this association can be improved.
- the shutter 10S and the block 10B described above correspond to an example of blocking means in the present invention. As the blocking means, the shutter 10S mechanism and the block 10B mechanism can be used in combination.
- the measurement apparatus 1C included in the measurement system MS4 includes three loading units 10a, 10b, and 10c and channel numbers corresponding to the loading units 10a, 10b, and 10c (FIG. 11). Shows CH1, CH2, CH3).
- the control unit of the measurement apparatus 1C selects the loading unit 10a as the loading unit 10 to be associated with the patient information including the identification information read by the barcode reader 2
- the display unit 14 of the measurement apparatus 1C The channel number “CH1” is displayed.
- the measuring apparatus 1C can indicate to the user which loading unit 10 is the selected dedicated loading unit.
- the display unit 14 has a function as a guiding means for guiding loading of a measuring tool such as the immunochromatographic test piece 4 and can also function as a display showing the measurement result.
- the measurement system MS4 shown in FIG. 11 can use, for example, the printer 13 having a built-in thermal print head as the guiding means.
- the printer 13 of the measuring apparatus 1C uses the channel number. By printing (here, CH1), it is displayed that the loading unit 10a has been selected.
- CH1 By printing (here, CH1), it is displayed that the loading unit 10a has been selected.
- the printer 13 also has a function as a normal printer that prints out a result of measuring a change caused by a reaction performed inside or on the surface of the immunochromatographic test piece 4 as a paper material corresponding to an inspection item. You can also.
- the speaker 15 can be used as a guiding means.
- the speaker 15 of the measuring apparatus 1C displays a voice message such as “Please load in CH1” in order to inform the user of the selected dedicated loading unit (here, CH1).
- the speaker 15 not only utters the channel number as described above, but can also guide the speaker 15 by uttering relative positional information such as “the loading portion is at the right end”.
- the speaker 15 can also display the measurement result information such as “measurement result is 120 mg / dl” for the blind user or patient. .
- the user can easily associate the patient information specified by reading with the barcode reader 2 with the measurement result obtained from the patient-derived specimen. In addition, the certainty of this association can be improved.
- the speaker 15 can also serve as a speaker for generating various warning sounds (buzzer sounds) in the entire measurement system MS4.
- description of the channel number to the measuring apparatus 1C can be performed by painting, tampo printing, engraving, concave / convex molding at the time of molding of the main body, and the method is not particularly limited.
- the measurement system MS5 includes a display 14 provided in the measurement apparatus 1D as a notification method for the user when a measurement tool such as an immunochromatographic test piece 4 is correctly loaded at the induced position. It is adopted that “OK” or the like is displayed on a display device such as the printer 13. This notification can also be made by the speaker 15. In this way, the user can easily and reliably know that the measuring device such as the immunochromatographic test strip 4 is loaded in the correct loading unit 10 selected by the control unit of the measuring apparatus 1D.
- the control unit 17 included in the measurement system MS6 includes a patient's record including identification information recorded on a medical chart read by the barcode reader 2 or the like or a barcode 3 attached to a specimen container.
- the information is configured to collate with the information recorded on the bar code 45 attached to the immunochromatographic test piece 4A.
- the number given to the immunochromatographic test piece 4A in advance is encoded and recorded on the case of the immunochromatographic test piece 4A, and the first patient information (barcode 3) read on the chart etc. Also, the number is recorded as a part thereof.
- the immunochromatographic test piece 4A is guided by the indicator lamp 11 and loaded into the loading unit 10 of the measuring apparatus 1E.
- the number information read by the area sensor 16A installed in the loading unit 10 is the same as the number information given to the immunochromatographic test piece 4A included in the patient information read first. Judge whether there is. If the numbers do not match, the speaker 15 issues a warning sound to inform the user that the loading position is incorrect. According to this, since the frequency of sample mix-up can be reduced, the reliability of the association between the patient information read in advance by the barcode reader 2 and the measurement result obtained from the sample derived from the patient can be further improved. I can do it.
- the barcode 45 attached to the immunochromatographic test piece 4A may record patient identification information. In this case, it is determined whether or not the patient identification information read by the barcode reader 2 and the patient identification information recorded on the barcode 45 attached to the immunochromatographic test piece 4A match. Is done.
- the present invention is not limited to the contents of the above-described embodiment.
- the specific type of specimen analyzed by the measurement system according to the present invention is not limited.
- the specimen is not limited to fluid collected from the mucous membrane of the pharynx or nasal cavity, but can be body fluid such as urine, blood, saliva, and other substances.
- the measuring tool used in the measuring system according to the present invention is not limited to the immunochromatographic test piece 4, but a test piece in which a reagent layer impregnated with a chemical reaction reagent is attached to a support, a dry measuring cell in a disposable measuring cell, or A measuring tool in which a liquid reagent is enclosed can also be used.
- a biosensor-type test piece that performs electrochemical measurement can also be used as another measurement tool.
- a biosensor-type test piece generally includes an oxidoreductase and a conductive electrode that cause an electron transfer reaction with a desired component in a specimen on a support.
- the measuring apparatus includes a conductive connector for contacting the conductive electrode at the back of the loading unit as a measuring unit. The oxidoreductase reacts with the desired component on the support, and the current generated in proportion to the concentration of the desired component is measured and converted to the desired component amount.
- the reading means used in the measurement system according to the present invention discloses a combination of the barcode 3 and the barcode reader 2 as an example in the above embodiment, but is not limited thereto.
- the display of the measuring device is a touch panel, and the patient information including a plurality of identification information to be measured that has been acquired in advance is displayed on the touch panel, and the patient information to be specified (display of ID number, name, etc.) is displayed.
- the information of a specific patient can be selected by touching the user.
- the measurement means used in the measurement system according to the present invention is not limited to the area sensor 16.
- an optical sensor unit comprising a combination of a light emitting module in which an LED that emits light of a certain wavelength is incorporated and a light receiving sensor module in which a plurality of photodiodes are arranged.
- Such an optical sensor unit is suitable for detecting the coloration generated in the entire specimen application area of the test piece.
- the measurement system it is also possible to perform measurement by loading a measurement tool into an empty loading unit 10 without reading patient information. Even during the measurement in which the patient information is associated with the measurement result obtained from the specimen derived from the patient, the measurement without associating the two can be performed in parallel.
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Abstract
Description
本発明が適用された測定システムの一例を図1および図2を参照して説明する。図1に示す測定システムMS1は、測定用具としてイムノクロマト試験片4を用いるものであり、病院などに設置されている。測定システムMS1は、複数の患者由来の検体を同時且つランダムに測定出来る測定システムである。測定システムMS1は、測定装置1とバーコードリーダ2とから構成されている。測定装置1とバーコードリーダ2は、ケーブル21により接続されている。ケーブル21は、図では有線形式とされているが、もちろん無線形式であってもよい。バーコードリーダ2は、本発明でいう読取手段の一例に相当するものである。読取手段としては、画像認識カメラを使用することも可能である。バーコードリーダ2は、患者のカルテや検体採取容器に貼り付けられた、識別情報(ID)などの患者の情報が記録されたバーコード3を読み取るためのものである。患者の情報は、ID番号又は氏名などの識別情報の他、疾患名又は投薬中の薬剤名などの情報を含んでいてもよい。なお、患者は、本発明でいう検体提供者の一例に相当するものである。また、本発明において、「識別情報を含む検体提供者の情報」は、検体提供者の情報が識別情報と識別情報以外の情報の両方を含んでいる場合だけではなく、識別情報のみを含んでいる場合を含む。
次に、図3~図6ならびに図7および図8のフローチャートを参照して、測定システムMS1を用いて行う測定方法の一例、ならびにこの測定方法を実施するために制御部17が実行する動作処理手順の一例について説明する。
図9~図12は、本発明の他の実施形態を示している。これらの図において、前記実施形態と同一又は類似の要素には、前記実施形態と同一の符号を付している。
Claims (15)
- 試薬を保持する測定用具が装填される複数の装填部を備える測定システムであって、
識別情報を含む検体提供者の情報を読み取るための読取手段と、
前記検体提供者由来の検体が適用された又はされる前記測定用具を、前記複数の装填部から選択され且つ前記読取手段により読み取られた前記識別情報により前記検体提供者に個別に対応付けされた装填部へ誘導するための誘導手段と、
を備える、測定システム。 - 請求項1に記載の測定システムであって、
前記誘導手段は、前記複数の装填部の各々に対応するように配置された複数の表示灯であり、前記表示灯は、点灯、消灯、又は色変化により誘導を行う、測定システム。 - 請求項1に記載の測定システムであって、
前記誘導手段は、前記検体提供者に個別に対応付けされた前記装填部を除く他の装填部への前記測定用具の装填を阻止するための阻止手段である、測定システム。 - 請求項3に記載の測定システムであって、
前記複数の装填部の各々は、前記測定用具を装填するための開口を備え、前記阻止手段は、前記他の装填部の前記開口を塞ぐ、測定システム。 - 請求項1に記載の測定システムであって、
前記誘導手段は、前記検体提供者に個別に対応付けされた前記装填部の位置情報を表示する表示装置である、測定システム。 - 請求項1に記載の測定システムであって、
前記検体提供者の前記情報は、バーコードとして記録されており、前記読取手段がバーコードリーダおよび画像認識カメラの少なくともいずれかである、測定システム。 - 請求項1に記載の測定システムであって、
前記読取手段はタッチパネルを含み、前記検体提供者の前記情報は、予め前記タッチパネル上に列記表示されており、前記タッチパネル上に列記表示された前記情報の中から特定の情報を使用者がタッチして選択する、測定システム。 - 請求項1に記載の測定システムであって、
前記複数の装填部の各々は、奥部に前記測定用具が装填されたことを認識することのできるセンサを備えている、測定システム。 - 請求項8に記載の測定システムであって、
前記読取手段により読み取られた前記情報により特定された前記検体提供者由来の前記検体が適用された前記測定用具が、前記検体提供者に個別に対応付けされた前記装填部以外の装填部へ装填されたことを前記センサが感知した場合に、前記測定用具が誤って装填されたことを警告するための警告手段を備える、測定システム。 - 試薬を保持する測定用具が装填される複数の装填部を備える測定システムを用いる測定方法であって、
識別情報を含む検体提供者の情報を読取手段により読み取るステップと、
前記複数の装填部から前記検体提供者由来の検体が適用された又はされる前記測定用具を装填するための装填部を選択し、且つこの装填部を前記識別情報により前記検体提供者に個別に対応付けするステップと、
前記検体提供者由来の検体が適用された又はされる前記測定用具を、前記検体提供者に個別に対応付けされた前記装填部へ誘導手段により誘導するステップと、
前記測定用具が前記装填部へ装填されたことを検知手段により検知するステップと、
前記検知するステップにより、前記検知手段が、前記測定用具が前記装填部内へ装填されたことを検知したことを契機として、測定手段による前記測定用具の測定を開始するステップと、
を有する、測定方法。 - 請求項10に記載の測定方法であって、
前記測定により得られたデータに基づき測定結果を算出するステップと、
前記測定結果を算出するステップにより得られた測定結果を、前記検体提供者の情報を読み取るステップにより読み取られた前記情報と共に、出力装置により出力するステップと、
を更に有する、測定方法。 - 試薬を保持する測定用具が装填される複数の装填部を備える測定システムの動作制御をコンピュータに実行させるためのプログラムであって、
識別情報を含む検体提供者の情報を読取手段により読み取るステップと、
前記複数の装填部から前記検体提供者由来の検体が適用された又はされる前記測定用具を装填するための装填部を選択し、且つこの装填部を前記識別情報により前記検体提供者に個別に対応付けするステップと、
前記検体提供者由来の検体が適用された又はされる前記測定用具を、前記検体提供者に個別に対応付けされた前記装填部へ誘導手段により誘導するステップと、
前記測定用具が前記装填部へ装填されたことを検知手段により検知するステップと、
前記検知するステップにより、前記検知手段が、前記測定用具が前記装填部内へ装填されたことを検知したことを契機として、測定手段による前記測定用具の測定を開始するステップと、
をコンピュータに実行させるためのプログラム。 - 請求項12に記載のコンピュータに実行させるためのプログラムであって、
前記測定により得られたデータに基づき測定結果を算出するステップと、
前記測定結果を算出するステップにより得られた測定結果を、前記検体提供者の情報を読み取るステップにより読み取られた前記情報と共に、出力装置により出力するステップと、
を更にコンピュータに実行させるためのプログラム。 - 請求項13に記載のコンピュータに実行させるプログラムであって、
前記測定用具が前記装填部から除去されたことを、前記検知手段により検知するステップと、
前記測定用具が前記装填部から除去されたことを契機として、前記装填部を新たな測定用具を受け入れ可能な状態とするステップと、
を更にコンピュータに実行させるためのプログラム。 - 請求項12ないし14のいずれかに記載のコンピュータに実行させるためのプログラムを記録したコンピュータ読み取り可能な記録媒体。
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