WO2012063798A1 - Buse pour récipient de médicament liquide - Google Patents

Buse pour récipient de médicament liquide Download PDF

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Publication number
WO2012063798A1
WO2012063798A1 PCT/JP2011/075668 JP2011075668W WO2012063798A1 WO 2012063798 A1 WO2012063798 A1 WO 2012063798A1 JP 2011075668 W JP2011075668 W JP 2011075668W WO 2012063798 A1 WO2012063798 A1 WO 2012063798A1
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WO
WIPO (PCT)
Prior art keywords
nozzle
container
chemical
hole
recess
Prior art date
Application number
PCT/JP2011/075668
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English (en)
Japanese (ja)
Inventor
忠史 大塚
Original Assignee
千寿製薬株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 千寿製薬株式会社 filed Critical 千寿製薬株式会社
Publication of WO2012063798A1 publication Critical patent/WO2012063798A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein

Definitions

  • the present invention relates to a chemical liquid container nozzle for dropping a chemical liquid in the container.
  • a cylindrical notch (52) is formed in the lower part (16) of the nozzle body (12) of the nozzle (11), and the inner wall (54) on the inside. And an outer sleeve (50). Accordingly, when the nozzle (11) is fitted into the mouth / neck portion (62) of the container body (60), the sleeve (50) is elastically deformed, so that the mouth / neck portion (62) of the container body (60) is cracked. Can be prevented.
  • Patent Document 1 when the container containing the chemical solution is inverted and instilled, the chemical solution enters the cylindrical notch, so that a large amount of unusable chemical solution remains in the container. become. Therefore, it is conceivable to fill the cylindrical notch, but then the nozzle loses its elasticity, and when the nozzle is fitted into the container body, leakage of the chemical solution from the fitting part or cracking of the container body or nozzle occurs. There is a fear.
  • Patent Document 2 describes a dripping nozzle suitable for eye drops in consideration of convenience and hygiene, which forms a communication hole having a diameter of 0.1 mm to 0.3 mm by irradiating laser light.
  • Patent Document 3 describes an internal stopper of a chemical solution container having radial ribs that can discharge a chemical solution by a substantially constant amount by a predetermined number of swinging operations.
  • the problem to be solved by the present invention is to provide a nozzle for a chemical solution container that can suppress the leakage of the chemical solution and can prevent the chemical solution from remaining in the container.
  • the invention according to claim 1 is a nozzle for a chemical solution container having a lower end portion fitted into a mouth portion of the chemical solution container, the tube opening in the vertical direction.
  • the bottom is recessed in an upward direction and the recess is formed in an annular shape so as to surround the inner hole, so that the inner cylinder part and the outer cylinder part are formed in an inner / outer double, and the minute hole that communicates the inside and outside of the inner hole
  • the restraining portion is composed of a plurality of plate-like portions, and the plurality of plate-like portions are radially extended so that the plate surface is along the vertical direction, and the respective lower end portions are located in the vicinity of the opening of the concave portion.
  • the invention according to claim 2 is the chemical solution container nozzle according to claim 1, wherein a hole diameter of the minute hole is 0.1 mm or more and less than 0.3 mm.
  • an invention according to claim 3 is an eye drop container comprising the chemical solution container nozzle according to claim 1 or claim 2.
  • FIG. 1 to 4 are views showing an embodiment of a nozzle for a chemical solution container according to the present invention.
  • FIG. 1 is a front view
  • FIG. 2 is a bottom view
  • FIG. 3 is a longitudinal sectional view in side view
  • FIG. It is a longitudinal cross-sectional view.
  • the nozzle for a chemical solution container is applied to various chemical solution containers, and drops a chemical solution stored in the container. For example, as described later, it is applied to an eye drop container.
  • the chemical container nozzle 1 of the present embodiment is made of a thermoplastic resin (for example, made of low density polyethylene) and is integrally formed by injection molding.
  • the chemical liquid container nozzle 1 includes a cylindrical nozzle body portion 2 opened in the vertical direction and a flange 4 formed on the nozzle body portion 2.
  • the nozzle main body 2 is formed into a thick, generally cylindrical shape that opens up and down, and the outer diameter of the upper portion is smaller than the outer diameter of the lower portion.
  • the upper surface of the part 2a is formed so as to bulge upward in a gentle spherical shape.
  • the inner hole 3 of the nozzle body 2 is formed such that the upper end is formed in a columnar shape, while the lower end is further reduced in diameter as it goes downward.
  • a flange 4 having a disk shape in a plan view is formed at a substantially central portion in the vertical direction of the nozzle body 2.
  • the flange 4 is formed to extend from the outer peripheral surface of the nozzle main body 2 in the shape of a disk outward in the radial direction, and then to extend downward in a cylindrical shape.
  • a recess 6 is formed in the lower end surface of the nozzle body 2 so as to be recessed upward.
  • the recess 6 is formed in an annular shape so as to surround the inner hole 3 of the nozzle body 2.
  • the nozzle body part 2 is formed with an inner cylinder part 7 arranged on the inner side and an outer cylinder part 8 arranged on the outer side in an inner / outer double manner.
  • the inner cylinder portion 7 has a cylindrical shape, is formed to extend downward from the lower end portion of the small-diameter cylinder portion 2a that is the upper portion of the nozzle body portion 2, and is gradually reduced in diameter as it goes downward.
  • the inner hole 9 of the inner cylinder part 7 is continuous with the inner hole of the small diameter cylinder part 2a. That is, the inner cylinder portion 7 has an inner hole 9 below the inner hole 3 of the nozzle body 2 and is disposed on the same axis as the nozzle body 2.
  • a closed portion 11 having a minute hole 10 is formed at the lower end portion of the inner cylinder portion 7.
  • the closing portion 11 is formed in a disk shape extending horizontally inward in the radial direction at the lowermost end of the inner cylinder portion 7.
  • a circular minute hole 10 that communicates the inside and outside of the inner hole 9 of the inner cylinder part 7 is formed in the approximate center of the disk-shaped blocking part 11.
  • the closing portion 11 is formed at the lowermost end of the inner cylinder portion 7, but it may be formed slightly higher than that. In this way, the lower end portion of the inner hole 3 of the nozzle body 2 is closed by the closing portion 11 leaving the minute hole 10. That is, the inside and outside of the inner hole 3 of the nozzle body 2 are communicated with each other through the minute hole 10.
  • the outer cylinder portion 8 has a cylindrical shape, the upper end portion is formed continuously with the lower end portion of the small diameter cylinder portion 2 a that is the upper portion of the nozzle body portion 2, and the lower end portion is substantially at the same position as the lower end portion of the inner cylinder portion 7.
  • the inner cylinder portion 7 is disposed on the same axis as the inner cylinder portion 7.
  • the outer diameter of the lower end part of the outer cylinder part 8 is formed by reducing the diameter as it goes downward.
  • the inner diameter of the upper end portion of the outer cylinder portion 8 is formed to be reduced in diameter as it goes upward. That is, the width of the upper end of the recess 6 becomes narrower as it goes upward.
  • Two annular convex portions 12 are formed on the outer peripheral surface of the outer cylindrical portion 8 along the circumferential direction at a substantially vertical center. Each convex part 12 is spaced apart in the up-down direction, and as shown in FIG. 3 and FIG. 4, the outer shape is formed in a substantially arc shape in each cross section.
  • the suppressing portion 13 includes a plurality (ten in the illustrated example) of plate-like portions 14, and the plurality of plate-like portions 14 extend radially from the inner cylinder portion 7 to the outer cylinder portion 8. Is formed. In the example of illustration, the angle
  • Each plate-like portion 14 is formed so as to extend from the upper end portion of the recess 6 to the vicinity of the opening which is the lower end portion so that the plate surface extends in the vertical direction, and the lower end portion is positioned substantially at the lower end portion of the recess 6. is doing.
  • the lower end surface of each plate-like portion 14 is located slightly above the lower end surface of the nozzle main body 2 and the distance between them is about 0.3 mm.
  • FIG. 5 is a perspective view showing one embodiment of a chemical container to which the chemical container nozzle 1 of the present embodiment is applied.
  • FIG. 6 is a longitudinal sectional view showing a usage state of the chemical liquid container nozzle 1 of the present embodiment.
  • the chemical liquid container 15 includes a container main body 17 in which the chemical liquid 16 is accommodated, a chemical liquid container nozzle 1 attached to the container main body 17, and a cap described later provided on the container main body 17 so as to cover the chemical liquid container nozzle 1. 22.
  • the container body 17 of the present embodiment includes a substantially cylindrical housing portion 18 whose bottom surface is closed and a cylindrical mouth portion 19 formed at the upper end portion of the housing portion 18 and is integrally formed of a thermoplastic resin. Yes.
  • the accommodating portion 18 is formed in a substantially cylindrical shape opening upward, and the upper end portion bulges upward in a gentle spherical shape, and is thin and can be pressed and deformed.
  • a cylindrical mouth portion 19 is formed at the upper end portion of the housing portion 18 so as to extend upward.
  • the mouth portion 19 has a cylindrical shape that is open in the up-down direction, and is arranged along the axis thereof in the up-down direction.
  • the inner hole 20 of the mouth portion 19 is a stepped circular hole, and the upper side is a small diameter hole 21.
  • the diameter of the small-diameter hole 21 of the mouth portion 19 is formed to be slightly smaller than the outer diameter of the convex portion 12 formed in the nozzle body portion 2.
  • the chemical liquid container nozzle 1 is detachably attached to the mouth 19 of the container body 17. Specifically, until the distal end portion of the mouth 19 of the container body 17 enters the recessed portion 5 formed in the chemical liquid container nozzle 1 and the upper wall of the recessed portion 5 comes into contact with the distal end of the mouth portion 19.
  • the outer cylinder portion 8 of the chemical liquid container nozzle 1 is fitted into the small diameter hole 21 of the mouth portion 19 from above.
  • the mouth portion 19 of the container body 17 is provided with a substantially cylindrical cap 22 that opens downward.
  • the screw thread 23 is formed on the outer peripheral surface of the mouth portion 19, and the thread groove is formed on the inner peripheral surface of the cap 22, so that the cap 22 can be screwed into the mouth portion 19. Accordingly, the cap 22 can be attached to and detached from the mouth portion 19.
  • the liquid medicine 16 accommodated in the liquid medicine container 15 having the above configuration is, for example, an eye drop.
  • the chemical solution container 15 is used as an eye drop container.
  • the inner holes 3 of the nozzle body 2 that is the flow path of the chemical solution 16 are opened at the upper and lower ends of the nozzle 1. Therefore, the flow path of the chemical liquid 16 in the nozzle 1 is secured to a sufficient length to suppress the leakage of the chemical liquid 16 from the upper end portion of the nozzle 1. Further, the lower end portion of the flow path of the chemical solution 16 in the nozzle 1 is closed except for the minute hole 10. As a result, when overturning or reversing, the chemical solution 16 in the container body 17 flows to the upper end side of the nozzle 1 through the minute hole 10, and the upper end of the nozzle 1 is compared with the case where there is no blocking portion 11. It is difficult to flow to the side. Therefore, the chemical liquid 16 can be prevented from leaking from the upper end portion of the nozzle 1.
  • the suppression part 13 is connected in the recessed part 6 of the nozzle main-body part 2, and it is set as the structure by which the chemical
  • the chemical liquid container nozzle of the present invention is not limited to the configuration of the above embodiment, and can be changed as appropriate.
  • the number of the plate-like portions 14 is not limited to the number in the above-described embodiment, and can be changed as appropriate. However, the number is preferably 8 to 12, more preferably 10. Moreover, the thickness of the plate-like part 14 is also set appropriately.
  • the chemical liquid container nozzle 1 is made of low density polyethylene, but is not particularly limited as long as it is a raw material resin usually used for injection molding.
  • linear low density polyethylene, polypropylene, or the like is used.
  • medical solution 16 accommodated in the container main body 17 is not necessarily limited to an eye drop, The chemical
  • the surface tension of the chemical liquid 16 accommodated in the chemical liquid container to which the chemical liquid container nozzle 1 of the present embodiment is applied is 45 mN / m or less, the effect of suppressing the leakage of the chemical liquid is remarkably exhibited.
  • Test 1 a nozzle according to a specific example of the present invention was compared with a conventional nozzle.
  • medical solution container nozzle 1 which has the structure of the said embodiment was used.
  • This nozzle 1 for a chemical solution container is manufactured by injection molding using low density polyethylene (“Sumikasen G-202” manufactured by Sumitomo Chemical Co., Ltd.), has a resin density of 0.919 g / cm 3 , a melt A flow rate of 1.5 g / 10 min was used.
  • the value of each part of the nozzle 1 is as shown in Table 1 below. As shown in FIG.
  • the inner hole 3 of the chemical liquid container nozzle 1 has a diameter a of the upper end of about 2.0 mm and a diameter b of the lower end of about 1.4 mm.
  • a conventional nozzle for a chemical solution container to be compared is as described later.
  • FIG. 7 is a longitudinal sectional view of a conventional chemical liquid container nozzle, which is a comparative example for confirming the effect of the chemical liquid container nozzle of the present invention.
  • a nozzle 101 for a chemical solution container of a comparative example includes a substantially cylindrical liquid injection part 102 opened up and down, a flange 103 formed at the lower end of the liquid injection part 102, and a flange 103 And a cylindrical fitting portion 104 formed at the lower end portion.
  • the liquid injection part 102 is formed in a thick, substantially cylindrical shape that opens in the vertical direction.
  • the inner hole 105 of the liquid injection part 102 is a stepped circular hole, and is a large-diameter hole 106, a medium-diameter hole 107, and a small-diameter hole 108 in order from the upper end side.
  • the flange 103 has a disk shape and is formed at the lower end of the liquid injection part 102 so as to extend horizontally outward in the radial direction.
  • the fitting portion 104 has a cylindrical shape larger in diameter than the liquid injection portion 102 and is formed to extend downward from the lower end portion of the flange 103.
  • Two annular convex portions 109 are formed on the outer peripheral surface of the fitting portion 104 at substantially the center in the vertical direction along the circumferential direction.
  • the chemical liquid container nozzle 101 configured as described above is applied to the chemical liquid container 15 in the same manner as the chemical liquid container nozzle of the present invention.
  • the value of each part of the nozzle 101 is as shown in Table 1 below.
  • Table 1 shows the test results.
  • the flow path indicates the inner hole 3 of the nozzle body 2 in the nozzle 1 of the embodiment, and the inner hole 105 of the liquid injection portion 102 in the nozzle 101 of the comparative example.
  • the hole diameter indicates the minute hole 10 in the nozzle 1 of the embodiment, and the small diameter hole 108 in the nozzle 101 of the comparative example.
  • the nozzle 1 of the example can suppress the leakage of the chemical liquid 16 from the upper end portion of the nozzle as compared with the nozzle 101 of the comparative example.
  • Test 2 In Test 2, in the nozzles of the specific examples of the present invention, Examples 1 to 5 having different hole diameters (micro holes 10 in the nozzle body 2) were compared with each other.
  • the nozzle 1 of Example 1 is the same as the Example used in Test 1 above, except for the hole diameter.
  • Each of the nozzles 1 of the second to fifth embodiments is the same as the first embodiment except for the hole diameter.
  • the time from reversal to dropping can be made 2.0 seconds or more by setting the hole diameter to less than 0.3 mm.
  • the hole diameter is preferably less than 0.3 mm.
  • the hole diameter is preferably 0.1 mm or more and less than 0.3 mm.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Devices For Medical Bathing And Washing (AREA)

Abstract

L'invention concerne une buse pour un récipient de médicament liquide qui supprime la fuite d'un médicament liquide et peut empêcher le médicament liquide de rester dans le récipient. Une buse pour un récipient de médicament liquide (1) comprend un corps principal de buse (2) sensiblement tubulaire qui est ouvert dans la direction verticale. Une collerette (4) est formée sensiblement au milieu du corps principal de buse dans la direction verticale. Au niveau de la surface d'extrémité inférieure du corps principal de buse (2) est formé un évidement (6) évidé vers le haut et de ce fait, une partie cylindrique interne (7) et une partie cylindrique externe (8) forment une structure à deux couches. A l'extrémité inférieure de la partie cylindrique interne (7), une partie de fermeture (11) comportant des microtrous (10) est formée. Dans l'évidement (6), une pluralité de parties en forme de plaque (14) sont disposées, qui s'étendent radialement, depuis la partie cylindrique interne (7) jusqu'à la partie cylindrique externe (8). Les parties en forme de plaque (14) sont formées de façon à s'étendre depuis l'extrémité supérieure de l'évidement (6) jusqu'à la zone proche de l'ouverture, qui constitue l'extrémité inférieure de l'évidement, de telle sorte que les surfaces des plaques s'étendent dans la direction verticale.
PCT/JP2011/075668 2010-11-09 2011-11-08 Buse pour récipient de médicament liquide WO2012063798A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010-250955 2010-11-09
JP2010250955A JP2014014381A (ja) 2010-11-09 2010-11-09 薬液容器用ノズル

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WO2012063798A1 true WO2012063798A1 (fr) 2012-05-18

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WO (1) WO2012063798A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015000746A (ja) * 2013-06-17 2015-01-05 伸晃化学株式会社 薬液容器の中栓
EP3034428A1 (fr) * 2014-12-19 2016-06-22 SHB GmbH Bouchon de dosage pour un flacon de dosage

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5710226B2 (ja) * 2010-11-26 2015-04-30 大成化工株式会社 点眼ノズル構造

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH074811Y2 (ja) * 1988-11-28 1995-02-08 株式会社吉野工業所 目薬容器
JP2535942Y2 (ja) * 1990-10-04 1997-05-14 富山科学工業株式会社 液体容器用中栓
JP2009261453A (ja) * 2008-04-22 2009-11-12 Hanshin Kasei Kogyo Kk 滴下ノズル

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH074811Y2 (ja) * 1988-11-28 1995-02-08 株式会社吉野工業所 目薬容器
JP2535942Y2 (ja) * 1990-10-04 1997-05-14 富山科学工業株式会社 液体容器用中栓
JP2009261453A (ja) * 2008-04-22 2009-11-12 Hanshin Kasei Kogyo Kk 滴下ノズル

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015000746A (ja) * 2013-06-17 2015-01-05 伸晃化学株式会社 薬液容器の中栓
EP3034428A1 (fr) * 2014-12-19 2016-06-22 SHB GmbH Bouchon de dosage pour un flacon de dosage
US10336511B2 (en) 2014-12-19 2019-07-02 Shb Gmbh Dosing cap for a dosing bottle

Also Published As

Publication number Publication date
JP2014014381A (ja) 2014-01-30

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