WO2012063798A1

WO2012063798A1 - Nozzle for liquid medicine container

Info

Publication number: WO2012063798A1
Application number: PCT/JP2011/075668
Authority: WO
Inventors: 忠史大塚
Original assignee: 千寿製薬株式会社
Priority date: 2010-11-09
Filing date: 2011-11-08
Publication date: 2012-05-18
Also published as: JP2014014381A

Abstract

[Problem] To provide a nozzle for a liquid medicine container that can suppress leakage of a liquid medicine and can keep the liquid medicine from remaining in the container. [Solution] A nozzle (1) for a liquid medicine container comprises a substantially tubular nozzle body (2) that is open in the vertical direction. A flange (4) is formed in substantially the middle of the nozzle body (2) in the vertical direction. At the bottom end surface of the nozzle body (2), a recess (6) is formed upwardly recessed and as a result an inner cylinder part (7) and an outer cylinder part (8) overlap. At the bottom end of the inner cylinder part (7), a closure part (11) having micro holes (10) is formed. In the recess (6), a plurality of plate shaped parts (14) are disposed extending in a radiating fashion, from the inner cylinder part (7) to the outer cylinder part (8). The plate shaped parts (14) are formed so as to extend from the top end of the recess (6) to the area near the opening, which is the bottom end of the recess, so that the plate surfaces extend in the vertical direction.

Description

Nozzle for chemical container

The present invention relates to a chemical liquid container nozzle for dropping a chemical liquid in the container.

Conventionally, when an eye drop container containing a chemical solution is tumbled or inverted, the chemical solution easily leaks from the tip of the nozzle, which may cause problems such as a decrease in the chemical solution or contamination. Therefore, as disclosed in Patent Document 1 below, the through holes of the nozzle (11) fitted into the mouth-and-neck portion (62) of the container body (60) are provided in the first chamber (20) and the second chamber (30). There is proposed a spout structure in which the first chamber (20) and the second chamber (30) are communicated with each other through the throttle chamber (40).

Moreover, in the spout structure disclosed in the following Patent Document 1, a cylindrical notch (52) is formed in the lower part (16) of the nozzle body (12) of the nozzle (11), and the inner wall (54) on the inside. And an outer sleeve (50). Accordingly, when the nozzle (11) is fitted into the mouth / neck portion (62) of the container body (60), the sleeve (50) is elastically deformed, so that the mouth / neck portion (62) of the container body (60) is cracked. Can be prevented.

However, in the invention described in Patent Document 1 below, when the container containing the chemical solution is inverted and instilled, the chemical solution enters the cylindrical notch, so that a large amount of unusable chemical solution remains in the container. become. Therefore, it is conceivable to fill the cylindrical notch, but then the nozzle loses its elasticity, and when the nozzle is fitted into the container body, leakage of the chemical solution from the fitting part or cracking of the container body or nozzle occurs. There is a fear. Patent Document 2 describes a dripping nozzle suitable for eye drops in consideration of convenience and hygiene, which forms a communication hole having a diameter of 0.1 mm to 0.3 mm by irradiating laser light. Yes. Patent Document 3 describes an internal stopper of a chemical solution container having radial ribs that can discharge a chemical solution by a substantially constant amount by a predetermined number of swinging operations.

JP 7-275322 A JP 2009-261453 A JP 2004-262467 A

The problem to be solved by the present invention is to provide a nozzle for a chemical solution container that can suppress the leakage of the chemical solution and can prevent the chemical solution from remaining in the container.

The present invention has been made to solve the above-mentioned problems, and the invention according to claim 1 is a nozzle for a chemical solution container having a lower end portion fitted into a mouth portion of the chemical solution container, the tube opening in the vertical direction. In the shape of a ring, the bottom is recessed in an upward direction and the recess is formed in an annular shape so as to surround the inner hole, so that the inner cylinder part and the outer cylinder part are formed in an inner / outer double, and the minute hole that communicates the inside and outside of the inner hole A nozzle main body part in which the lower end part of the inner hole is closed by leaving the micro hole, and a suppressing part connected to the concave part and suppressing the entry of the chemical into the concave part, The restraining portion is composed of a plurality of plate-like portions, and the plurality of plate-like portions are radially extended so that the plate surface is along the vertical direction, and the respective lower end portions are located in the vicinity of the opening of the concave portion. It is a nozzle for chemical | medical solution containers characterized by having.

The invention according to claim 2 is the chemical solution container nozzle according to claim 1, wherein a hole diameter of the minute hole is 0.1 mm or more and less than 0.3 mm.

Furthermore, an invention according to claim 3 is an eye drop container comprising the chemical solution container nozzle according to claim 1 or claim 2.

According to the present invention, it is possible to provide a chemical liquid container nozzle capable of suppressing the leakage of the chemical liquid and suppressing the chemical liquid from remaining in the container.

It is a front view which shows one Embodiment of the nozzle for chemical | medical solution containers of this invention. It is a bottom view of the nozzle for chemical | medical solution containers of FIG. It is a side view longitudinal cross-sectional view of the nozzle for chemical | medical solution containers of FIG. It is a front view longitudinal cross-sectional view of the nozzle for chemical | medical solution containers of FIG. It is a perspective view which shows one Embodiment of the chemical | medical solution container to which the nozzle for chemical | medical solution containers of FIG. 1 is applied. It is a longitudinal cross-sectional view which shows the use condition of the nozzle for chemical | medical solution containers of FIG. It is a longitudinal cross-sectional view of the conventional nozzle for chemical | medical solution containers.

Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.
1 to 4 are views showing an embodiment of a nozzle for a chemical solution container according to the present invention. FIG. 1 is a front view, FIG. 2 is a bottom view, FIG. 3 is a longitudinal sectional view in side view, and FIG. It is a longitudinal cross-sectional view. The nozzle for a chemical solution container is applied to various chemical solution containers, and drops a chemical solution stored in the container. For example, as described later, it is applied to an eye drop container.

The chemical container nozzle 1 of the present embodiment is made of a thermoplastic resin (for example, made of low density polyethylene) and is integrally formed by injection molding. The chemical liquid container nozzle 1 includes a cylindrical nozzle body portion 2 opened in the vertical direction and a flange 4 formed on the nozzle body portion 2. In the illustrated example, the nozzle main body 2 is formed into a thick, generally cylindrical shape that opens up and down, and the outer diameter of the upper portion is smaller than the outer diameter of the lower portion. The upper surface of the part 2a is formed so as to bulge upward in a gentle spherical shape. The inner hole 3 of the nozzle body 2 is formed such that the upper end is formed in a columnar shape, while the lower end is further reduced in diameter as it goes downward.

A flange 4 having a disk shape in a plan view is formed at a substantially central portion in the vertical direction of the nozzle body 2. The flange 4 is formed to extend from the outer peripheral surface of the nozzle main body 2 in the shape of a disk outward in the radial direction, and then to extend downward in a cylindrical shape. By forming the flange 4 in this way, an annular concave portion 5 opened downward is formed by the flange 4 and the nozzle body 2.

A recess 6 is formed in the lower end surface of the nozzle body 2 so as to be recessed upward. The recess 6 is formed in an annular shape so as to surround the inner hole 3 of the nozzle body 2. By forming the recess 6 in this manner, the nozzle body part 2 is formed with an inner cylinder part 7 arranged on the inner side and an outer cylinder part 8 arranged on the outer side in an inner / outer double manner.

The inner cylinder portion 7 has a cylindrical shape, is formed to extend downward from the lower end portion of the small-diameter cylinder portion 2a that is the upper portion of the nozzle body portion 2, and is gradually reduced in diameter as it goes downward. The inner hole 9 of the inner cylinder part 7 is continuous with the inner hole of the small diameter cylinder part 2a. That is, the inner cylinder portion 7 has an inner hole 9 below the inner hole 3 of the nozzle body 2 and is disposed on the same axis as the nozzle body 2. A closed portion 11 having a minute hole 10 is formed at the lower end portion of the inner cylinder portion 7. In the illustrated example, the closing portion 11 is formed in a disk shape extending horizontally inward in the radial direction at the lowermost end of the inner cylinder portion 7. A circular minute hole 10 that communicates the inside and outside of the inner hole 9 of the inner cylinder part 7 is formed in the approximate center of the disk-shaped blocking part 11. In the illustrated example, the closing portion 11 is formed at the lowermost end of the inner cylinder portion 7, but it may be formed slightly higher than that. In this way, the lower end portion of the inner hole 3 of the nozzle body 2 is closed by the closing portion 11 leaving the minute hole 10. That is, the inside and outside of the inner hole 3 of the nozzle body 2 are communicated with each other through the minute hole 10.

The outer cylinder portion 8 has a cylindrical shape, the upper end portion is formed continuously with the lower end portion of the small diameter cylinder portion 2 a that is the upper portion of the nozzle body portion 2, and the lower end portion is substantially at the same position as the lower end portion of the inner cylinder portion 7. The inner cylinder portion 7 is disposed on the same axis as the inner cylinder portion 7. The outer diameter of the lower end part of the outer cylinder part 8 is formed by reducing the diameter as it goes downward. On the other hand, the inner diameter of the upper end portion of the outer cylinder portion 8 is formed to be reduced in diameter as it goes upward. That is, the width of the upper end of the recess 6 becomes narrower as it goes upward. Two annular convex portions 12 are formed on the outer peripheral surface of the outer cylindrical portion 8 along the circumferential direction at a substantially vertical center. Each convex part 12 is spaced apart in the up-down direction, and as shown in FIG. 3 and FIG. 4, the outer shape is formed in a substantially arc shape in each cross section.

In the recess 6 which is a cylindrical gap between the inner cylinder part 7 and the outer cylinder part 8, a suppressing part 13 is connected. In the present embodiment, the suppressing portion 13 includes a plurality (ten in the illustrated example) of plate-like portions 14, and the plurality of plate-like portions 14 extend radially from the inner cylinder portion 7 to the outer cylinder portion 8. Is formed. In the example of illustration, the angle | corner which the adjacent plate-shaped

parts

14 and 14 make is formed equally, respectively. Each plate-like portion 14 is formed so as to extend from the upper end portion of the recess 6 to the vicinity of the opening which is the lower end portion so that the plate surface extends in the vertical direction, and the lower end portion is positioned substantially at the lower end portion of the recess 6. is doing. For example, the lower end surface of each plate-like portion 14 is located slightly above the lower end surface of the nozzle main body 2 and the distance between them is about 0.3 mm.

FIG. 5 is a perspective view showing one embodiment of a chemical container to which the chemical container nozzle 1 of the present embodiment is applied. FIG. 6 is a longitudinal sectional view showing a usage state of the chemical liquid container nozzle 1 of the present embodiment. The chemical liquid container 15 includes a container main body 17 in which the chemical liquid 16 is accommodated, a chemical liquid container nozzle 1 attached to the container main body 17, and a cap described later provided on the container main body 17 so as to cover the chemical liquid container nozzle 1. 22. The container body 17 of the present embodiment includes a substantially cylindrical housing portion 18 whose bottom surface is closed and a cylindrical mouth portion 19 formed at the upper end portion of the housing portion 18 and is integrally formed of a thermoplastic resin. Yes.

The accommodating portion 18 is formed in a substantially cylindrical shape opening upward, and the upper end portion bulges upward in a gentle spherical shape, and is thin and can be pressed and deformed. A cylindrical mouth portion 19 is formed at the upper end portion of the housing portion 18 so as to extend upward. The mouth portion 19 has a cylindrical shape that is open in the up-down direction, and is arranged along the axis thereof in the up-down direction. The inner hole 20 of the mouth portion 19 is a stepped circular hole, and the upper side is a small diameter hole 21. The diameter of the small-diameter hole 21 of the mouth portion 19 is formed to be slightly smaller than the outer diameter of the convex portion 12 formed in the nozzle body portion 2.

As shown in FIG. 6, the chemical liquid container nozzle 1 is detachably attached to the mouth 19 of the container body 17. Specifically, until the distal end portion of the mouth 19 of the container body 17 enters the recessed portion 5 formed in the chemical liquid container nozzle 1 and the upper wall of the recessed portion 5 comes into contact with the distal end of the mouth portion 19. The outer cylinder portion 8 of the chemical liquid container nozzle 1 is fitted into the small diameter hole 21 of the mouth portion 19 from above.

By the way, the mouth portion 19 of the container body 17 is provided with a substantially cylindrical cap 22 that opens downward. Specifically, the screw thread 23 is formed on the outer peripheral surface of the mouth portion 19, and the thread groove is formed on the inner peripheral surface of the cap 22, so that the cap 22 can be screwed into the mouth portion 19. Accordingly, the cap 22 can be attached to and detached from the mouth portion 19. The liquid medicine 16 accommodated in the liquid medicine container 15 having the above configuration is, for example, an eye drop. In this case, the chemical solution container 15 is used as an eye drop container.

In the case of the above-described embodiment, the inner holes 3 of the nozzle body 2 that is the flow path of the chemical solution 16 are opened at the upper and lower ends of the nozzle 1. Therefore, the flow path of the chemical liquid 16 in the nozzle 1 is secured to a sufficient length to suppress the leakage of the chemical liquid 16 from the upper end portion of the nozzle 1. Further, the lower end portion of the flow path of the chemical solution 16 in the nozzle 1 is closed except for the minute hole 10. As a result, when overturning or reversing, the chemical solution 16 in the container body 17 flows to the upper end side of the nozzle 1 through the minute hole 10, and the upper end of the nozzle 1 is compared with the case where there is no blocking portion 11. It is difficult to flow to the side. Therefore, the chemical liquid 16 can be prevented from leaking from the upper end portion of the nozzle 1.

Furthermore, in the case of the said embodiment, the suppression part 13 is connected in the recessed part 6 of the nozzle main-body part 2, and it is set as the structure by which the chemical | medical solution 16 is suppressed from entering into the recessed part 6. FIG. Specifically, a plurality of plate-like portions 14 are formed radially, and a plurality of substantially fan-shaped gaps are formed. By taking such a form, when the nozzle 1 is inverted and dropped so as to face downward, the chemical solution 16 is prevented from entering the recess 6, so that the unusable chemical solution 16 remains in the container 15. The chemical solution 16 can be used without waste.

The chemical liquid container nozzle of the present invention is not limited to the configuration of the above embodiment, and can be changed as appropriate. For example, the number of the plate-like portions 14 is not limited to the number in the above-described embodiment, and can be changed as appropriate. However, the number is preferably 8 to 12, more preferably 10. Moreover, the thickness of the plate-like part 14 is also set appropriately.

In the above embodiment, the chemical liquid container nozzle 1 is made of low density polyethylene, but is not particularly limited as long as it is a raw material resin usually used for injection molding. For example, linear low density polyethylene, polypropylene, or the like is used. . Moreover, the chemical | medical solution 16 accommodated in the container main body 17 is not necessarily limited to an eye drop, The chemical | medical solution which needs to dripping a fixed amount like an ear drop liquid or a nasal drop is accommodated.

When the surface tension of the chemical liquid 16 accommodated in the chemical liquid container to which the chemical liquid container nozzle 1 of the present embodiment is applied is 45 mN / m or less, the effect of suppressing the leakage of the chemical liquid is remarkably exhibited. In particular, it is effective to use the nozzle 1 for the chemical liquid container of the present embodiment when the surface tension of the chemical liquid 16 is 25 to 45 mN / m, and this implementation is performed when the surface tension of the chemical liquid 16 is 30 to 40 mN / m. It is more effective to use the chemical liquid container nozzle 1 in the form.

Hereinafter, a test conducted for confirming the action and effect of the chemical container nozzle of the present invention will be described.

(Test 1)
In Test 1, a nozzle according to a specific example of the present invention was compared with a conventional nozzle. As an Example, the chemical | medical solution container nozzle 1 which has the structure of the said embodiment was used. This nozzle 1 for a chemical solution container is manufactured by injection molding using low density polyethylene (“Sumikasen G-202” manufactured by Sumitomo Chemical Co., Ltd.), has a resin density of 0.919 g / cm ³ , a melt A flow rate of 1.5 g / 10 min was used. In addition, the value of each part of the nozzle 1 is as shown in Table 1 below. As shown in FIG. 3, the inner hole 3 of the chemical liquid container nozzle 1 has a diameter a of the upper end of about 2.0 mm and a diameter b of the lower end of about 1.4 mm. On the other hand, a conventional nozzle for a chemical solution container to be compared is as described later.

FIG. 7 is a longitudinal sectional view of a conventional chemical liquid container nozzle, which is a comparative example for confirming the effect of the chemical liquid container nozzle of the present invention. As shown in this figure, a nozzle 101 for a chemical solution container of a comparative example includes a substantially cylindrical liquid injection part 102 opened up and down, a flange 103 formed at the lower end of the liquid injection part 102, and a flange 103 And a cylindrical fitting portion 104 formed at the lower end portion.

The liquid injection part 102 is formed in a thick, substantially cylindrical shape that opens in the vertical direction. The inner hole 105 of the liquid injection part 102 is a stepped circular hole, and is a large-diameter hole 106, a medium-diameter hole 107, and a small-diameter hole 108 in order from the upper end side. The flange 103 has a disk shape and is formed at the lower end of the liquid injection part 102 so as to extend horizontally outward in the radial direction. The fitting portion 104 has a cylindrical shape larger in diameter than the liquid injection portion 102 and is formed to extend downward from the lower end portion of the flange 103. Two annular convex portions 109 are formed on the outer peripheral surface of the fitting portion 104 at substantially the center in the vertical direction along the circumferential direction. The chemical liquid container nozzle 101 configured as described above is applied to the chemical liquid container 15 in the same manner as the chemical liquid container nozzle of the present invention. In addition, the value of each part of the nozzle 101 is as shown in Table 1 below.

In conducting the test, first, 1 ml of the chemical solution 16 having a surface tension of 31 mN / m was accommodated in the container body 17 of the chemical solution container 15. And the nozzle 1 of the Example was attached to the mouth part 19 of the container main body 17. In this test 1, the container main body 17 was inverted so that the nozzle 1 was directed downward, and immediately after that, the container body 17 was left to stand in a test tube stand, and the time from when it was allowed to stand until one drop of the drug solution 16 was measured. Similarly, in the case of the nozzle 101 of the comparative example, the time until the chemical solution 16 dropped was measured. In this manner, each of the nozzle 1 of the example and the nozzle 101 of the comparative example was tested.

Table 1 shows the test results. In Table 1, the flow path indicates the inner hole 3 of the nozzle body 2 in the nozzle 1 of the embodiment, and the inner hole 105 of the liquid injection portion 102 in the nozzle 101 of the comparative example. Further, the hole diameter indicates the minute hole 10 in the nozzle 1 of the embodiment, and the small diameter hole 108 in the nozzle 101 of the comparative example.

As can be seen from Table 1, it was confirmed that the longer the nozzle flow path, the longer the time until dropping. Therefore, it was clarified that the nozzle 1 of the example can suppress the leakage of the chemical liquid 16 from the upper end portion of the nozzle as compared with the nozzle 101 of the comparative example.

(Test 2)
In Test 2, in the nozzles of the specific examples of the present invention, Examples 1 to 5 having different hole diameters (micro holes 10 in the nozzle body 2) were compared with each other. The nozzle 1 of Example 1 is the same as the Example used in Test 1 above, except for the hole diameter. Each of the nozzles 1 of the second to fifth embodiments is the same as the first embodiment except for the hole diameter.

In conducting the test, first, 1 ml of the chemical solution 16 having a surface tension of 31 mN / m was accommodated in the container body 17 of the chemical solution container 15. The nozzle 1 of Example 1 was attached to the mouth 19 of the container body 17. In this test 2, the container main body 17 was inverted so that the nozzle 1 was directed downward, and immediately after that, the container body 17 was left standing in a test tube stand, and the time from when it was allowed to stand until one drop of the drug solution 16 was measured. Similarly, for each of the nozzles 1 of Examples 2 to 5, the time until one drop of the chemical solution 16 was measured. In this way, each nozzle 1 of Examples 1 to 5 was tested.

As can be seen from Table 2, it was confirmed that when the hole diameter was made smaller, the time until the drop became longer. Therefore, by reducing the hole diameter, the leakage of the chemical liquid 16 from the upper end of the nozzle can be more reliably suppressed.

It was also confirmed that the time from reversal to dropping can be made 2.0 seconds or more by setting the hole diameter to less than 0.3 mm. Here, consider the case where the nozzle 1 is applied to an eye drop container. In this case, in consideration of the time until the nozzle 1 is inverted so that the nozzle 1 is directed downward, it is preferable that the time until one drop falls is defined as 2.0 seconds or more. Therefore, from the viewpoint of ease of instillation, the hole diameter is preferably less than 0.3 mm. In addition, when it is less than 0.1 mm, there is a possibility that an appropriate amount of the chemical solution cannot be dropped when instilling. Therefore, the hole diameter is preferably 0.1 mm or more and less than 0.3 mm.

DESCRIPTION OF SYMBOLS 1 Nozzle for chemical | medical solution containers 2 Nozzle main-body part 2a Small diameter cylinder part 3 Inner hole 4 Flange 5 Concave part 6 Concave part 7 Inner cylinder part 8 Outer cylinder part 9 Inner hole 10 Micro hole 11 Closed part 12 Convex part 13 Inhibition part 14 Plate-like part DESCRIPTION OF SYMBOLS 15 Chemical solution container 16 Chemical solution 17 Container main body 18 Storage part 19 Mouth part 20 Inner hole 21 Small diameter hole 22 Cap 23 Screw thread

Claims

A chemical container nozzle whose lower end is fitted into the mouth of the chemical container,
It is a cylindrical shape that opens in the vertical direction. It is formed in an annular shape so that it is recessed upward at the lower end surface and the recess surrounds the inner hole. A nozzle main body portion in which the lower end portion of the inner hole is closed by leaving the minute hole by a closing portion having a minute hole communicating between the inside and the outside,
A suppressor connected to the recess and suppressing the entry of the chemical into the recess,
The suppression part is composed of a plurality of plate-like parts,
The plurality of plate-like portions are radially extended so that the plate surfaces thereof extend in the vertical direction, and the lower ends of the plate-like portions are located in the vicinity of the openings of the recesses.
The hole diameter of the said micro hole is 0.1 mm or more and less than 0.3 mm. The nozzle for chemical | medical solution containers of Claim 1 characterized by the above-mentioned.
An eye drop container comprising the chemical liquid container nozzle according to claim 1.