WO2011107024A1 - 一种动脉瘤手术装置 - Google Patents

一种动脉瘤手术装置 Download PDF

Info

Publication number
WO2011107024A1
WO2011107024A1 PCT/CN2011/071447 CN2011071447W WO2011107024A1 WO 2011107024 A1 WO2011107024 A1 WO 2011107024A1 CN 2011071447 W CN2011071447 W CN 2011071447W WO 2011107024 A1 WO2011107024 A1 WO 2011107024A1
Authority
WO
WIPO (PCT)
Prior art keywords
stent
microcatheter
aneurysm
guide wire
mesh
Prior art date
Application number
PCT/CN2011/071447
Other languages
English (en)
French (fr)
Inventor
金巧蓉
李�雨
王森
谢志永
罗七一
Original Assignee
微创医疗器械(上海)有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 微创医疗器械(上海)有限公司 filed Critical 微创医疗器械(上海)有限公司
Priority to KR1020127022741A priority Critical patent/KR101498531B1/ko
Priority to US13/581,728 priority patent/US20130066413A1/en
Priority to EP11750177.5A priority patent/EP2543345B1/en
Priority to ES11750177T priority patent/ES2697513T3/es
Priority to JP2012555290A priority patent/JP5814949B2/ja
Publication of WO2011107024A1 publication Critical patent/WO2011107024A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A61B17/12118—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm for positioning in conjunction with a stent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2002/823—Stents, different from stent-grafts, adapted to cover an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0015—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in density or specific weight

Definitions

  • the present application relates to the field of medical devices, and in particular to an aneurysm surgical device. Background technique
  • An aneurysm is caused by a disease, injury, or congenital factor in the arterial wall.
  • the blood vessel wall is partially weakened. Under the impact of blood flow, the weak point of the blood vessel wall gradually expands outward.
  • Aneurysms can occur in different parts of the body, most commonly abdominal aortic aneurysms and intracranial aneurysms.
  • the goal of aneurysm treatment is to reduce the risk of aneurysm rupture.
  • the most fundamental method is to achieve the healing of the parental artery and the reconstruction of the anatomy of the artery wall.
  • intravascular interventional treatment of iliac aneurysms is mainly based on the method of stent-assisted coils, that is, the stent with appropriate density is transported into the diseased vessel, and then the coil is transported from the pore of the stent into the aneurysm, and the aneurysm is filled.
  • the purpose of treatment Since the terminal behavior of aneurysm tamponade occurs in the aneurysm cavity, the applicant has found that the existing stent-assisted coils have a placeholder effect in the treatment of an aneurysm, and a tumor appears in the process of treating the aneurysm.
  • the embodiment of the present application provides an aneurysm surgical device, and the technical solution is as follows:
  • An aneurysm surgical device includes: a stent, a delivery guidewire, an introduction sheath, and a microcatheter, wherein - the stent is a self-expanding stent;
  • the delivery guide wire is disposed in the introduction sheath inner cavity, and the bracket is externally bound thereto;
  • the introducer sheath is coupled to the microcatheter and communicates with the lumen to form a channel for transporting the delivery guidewire and the stent into the body.
  • the self-expanding stent is woven from a biocompatible metal wire chain and/or a polymer wire chain.
  • the structure of the self-expanding stent is a mesh tubular structure.
  • the compression ratio of the tubular structure in the radial direction is in the range of 1: 2 to 1:10.
  • the mesh tubular structure is a uniform mesh structure.
  • the coverage of the uniform grid structure is in the range of 20% to 60%.
  • the coverage of the uniform grid structure is in the range of 30% to 50%.
  • the mesh tubular structure has an uneven mesh structure in the axial direction and/or the radial direction at the position of the aneurysm, and the remaining portion is a uniform mesh structure.
  • the coverage of the uneven grid structure is in the range of 40% to 60%.
  • the coverage of the uniform grid structure is in the range of 20% to 40%.
  • the conveying guide wire comprises:
  • the material of the spring element, the boss and the conveying element is a developing material.
  • the structure of the introduction sheath is a hollow structure.
  • the material introduced into the sheath is a polymer material.
  • the polymer material is a PTFE material, an HDFE material or a FEP material.
  • the microcatheter comprises:
  • the tubular body is a stepped hollow structure whose diameter gradually decreases from the proximal end to the distal end and the hardness gradually decreases from the proximal end to the distal end;
  • a stress diffusion tube one end of which is connected to the tube body for preventing the proximal end of the tube body from being folded
  • the material of the pipe body is from the inside to the outside: a smooth layer, a reinforcing layer and an outer layer, and the materials thereof are a polymer material, a metal and/or a polymer, and a polymer material, respectively.
  • the distal end of the tubular body is further provided with a developing element for displaying the position of the microcatheter in the blood vessel.
  • the stent in the aneurysm surgical device of the embodiment of the present application has a high-density mesh structure, so that the stent has a high coverage, especially a high coverage on the stent near the aneurysm.
  • the rate and uneven grid structure make the stent after release, which is equivalent to reconstructing the arterial wall in the vascular lesion, which significantly changes the direction of blood flow in the lesion, avoids the impact of blood on the inner wall of the aneurysm, and then achieves treatment.
  • the dense mesh of the stent serves as a support for the growth or migration of vascular endothelial cells.
  • the stent is bound to the delivery guide wire, and the stent and the delivery guide wire are pre-installed in the introduction sheath.
  • the microcatheter is first inserted into the diseased blood vessel, and then the introduction sheath and the micro-introduction are introduced.
  • the catheter is connected, and by applying an axial direction force to the delivery guidewire, the stent bound to the delivery guidewire can be transported from the introducer sheath into the microcatheter and moved to the vascular lesion by adjusting the delivery guidewire and the microcatheter. Relative position, finally positioning the stent and releasing it to the lesion of the blood vessel.
  • the stent in the aneurysm surgical device of the embodiment of the present application can also be supported or blocked as an embolic material in the aneurysm (such as a detachable coil, a plugging liquid, etc.) to ensure that the embolic material is only In the aneurysm, maintain the patency of the tumor-bearing artery, and assist in the treatment of vascular aneurysms.
  • an embolic material in the aneurysm such as a detachable coil, a plugging liquid, etc.
  • FIG. 1 is a schematic structural view of an aneurysm surgical device according to an embodiment of the present invention
  • FIG. 2 is a partial cross-sectional view of an aneurysm surgical device according to an embodiment of the present application
  • FIG. 4 is a schematic view showing the compression of the stent of the embodiment of the present application.
  • FIG. 5 is a schematic plan view of a mesh tubular structure of a stent according to an embodiment of the present application
  • FIG. 6 is a schematic structural view of a guide wire according to an embodiment of the present application
  • FIG. 7 is a schematic structural view of a boss and a conveying member for conveying a guide wire according to an embodiment of the present application
  • FIG. 8 is a schematic structural view of a microcatheter according to an embodiment of the present application
  • 9 is a schematic view of a stent delivered to a vascular lesion in the embodiment of the present invention
  • FIG. 10 is a schematic view of the stent released by the push-and-push method according to an embodiment of the present application; Schematic diagram. detailed description
  • the most fundamental method for the treatment of aneurysms is: to achieve the healing of the mother-bearing arteries, the reconstruction of the anatomy of the arterial wall.
  • the existing vascular interventional treatment using a surgical stent-assisted coil has a risk of occupying effect, embolization, and rupture of an aneurysm during or after an aneurysm treatment.
  • the embodiment of the present application provides an aneurysm surgical device capable of delivering a high-density and ultra-soft stent to a vascular lesion and releasing the stent, and the grid structure of the stent has a high coverage, so that the stent is released into the blood vessel.
  • FIG. 1 is a schematic view showing the external structure of the aneurysm surgical device
  • FIG. 2 is a partial cross-sectional view of the surgical vascular device.
  • the aneurysm surgical device includes: a stent 1, a delivery guidewire 2, an introduction sheath 3, and a microcatheter 4.
  • the stent 1 is bound to the outside of the distal end of the delivery guide wire 2 for supporting the diseased blood vessel; the delivery guide wire 2 is disposed inside the introduction sheath 3 for conveying the stent; and the introduction sheath 3 is used for pre-prevention
  • the stent 1 and the delivery guide wire 2 are attached, and the distal end of the introduction sheath 3 is connected to the microcatheter 4 for conveying the delivery guide wire 2 and the stent 1 into the microcatheter 4; the microcatheter 4 is used for conveying the guide wire 2 when transporting And the stent 1 provides access to the diseased blood vessel.
  • Bracket 1 is a highly flexible and flexible self-expanding stent with a highly dense continuous mesh tubular structure.
  • the stent 1 is woven from a biocompatible metal wire chain and/or a polymer wire chain.
  • each wire chain of the mesh tubular structure has a braiding angle with respect to the radial direction, and the angle ranges from Between 15 degrees and 85 degrees, to ensure that the bracket 1 has sufficient supporting force in the radial direction and the circumferential direction.
  • the continuous chain 1-1 in the axial direction rotates around the chain weaving point 1-2, so that the bracket 1 has sufficient flexibility to flex or twist in space to release it.
  • the above variable structure of the bracket 1 is such that it also has a high compressible ratio, and the compression ratio can be in the range of 1:2-1:10, and the compressed bracket 1 can be loaded into the tube.
  • the lead sheath or microcatheter has a diameter of 0.3 mm to 1.5 mm.
  • the mesh tubular structure of the bracket 1 may be a uniform uniform mesh. As shown in FIG. 5( a ), the coverage of the continuous mesh of the hooks is in the range of 20% to 60%. In the embodiment of the present application, the uniformity is uniform. The coverage of continuous grids is chosen between 30% and 50%.
  • the mesh tubular structure of the stent 1 may also have an uneven mesh structure in the axial direction and/or the radial direction at the position of the aneurysm, and the rest is a uniform mesh structure.
  • the uneven continuous mesh is transported into the blood vessel, it is transported to the vascular area near the mouth of the aneurysm or the aneurysm, where the grid coverage is also the highest, reaching 40%. ⁇ 60%, such a high coverage can change the blood flow in the aneurysm to the maximum extent.
  • the conveying guide wire 2 comprises: a metal core 2-1, a spring element 2-2, a boss 2-3 and a plurality of conveying positioning members 2-4, wherein: the metal core 2-1 has a structure of Proximal to distal
  • the linear structure, the stepped structure with a decreasing diameter, and the linear structure are used to transport and support the bracket 1.
  • the spring element 2-2 covers the distal linear structure and the intermediate stepped structure of the metal core 2-1.
  • the boss 2-3 is fixed to the metal core 2-1 for providing thrust to the bracket 1 during transportation.
  • a plurality of conveying positioning members 2-4 are fixed to the outer surface of the spring member 2-2 or the metal core 2-1 at a position before the boss 2-3 for providing thrust or recovery force to the bracket 1 during transportation.
  • the material of the metal core 2-1 may be selected from stainless steel, nickel titanium alloy, copper alloy, aluminum alloy, etc., and the metal core 2-1 may be ground by one material or may be bonded or welded by two materials.
  • the diameter is gradually reduced from the proximal linear structure with a diameter of 0.025 ⁇ 0.012 inches to the distal linear structure with a diameter of 0.012 ⁇ 0.002 inches according to the degree of tortuosity of the blood vessel.
  • the length of the proximal linear structure can be 1500 ⁇ 2000mm. In the range, the length of the intermediate stepped structure may be in the range of 300 to 500 mm, and the length of the distal linear structure may be in the range of 10 to 30 mm.
  • the boss 2-3 is formed as a metal ring piece. As shown in Fig.
  • the shape of the conveying member 2-4 is provided with four rounded angular polygons on the outer side, the number of which is determined according to the length of the bracket 1, and the conveying member 2-4 is conveyed by the angular friction and / or embedded in the grid of the bracket 1 to drive the bracket 1 to move forward or backward.
  • the material of the spring element 2-2, the boss 2-3 and the conveying positioning member 2-4 is selected from materials such as tantalum, platinum, gold, tungsten or developed polymer.
  • the introduction sheath 3 is a hollow polymer tube having a low coefficient of friction, and the material thereof may be a PTFE material, an HDPE material, or a FEP material.
  • the microcatheter 4 includes: a tube body 4-1, a stress diffusion tube 4-2, and a connecting member. 4-3 and developing member 4-4, wherein: the structure of the tube body 4-1 is a stepped hollow structure in which the diameter gradually decreases from the proximal end to the distal end, and the hardness gradually decreases from the proximal end to the distal end.
  • the tube body 4-1 has different structures, different hardnesses, and different diameters in the axial direction depending on the degree of warpage of the blood vessel and the size of the blood vessel.
  • the structure is a linear structure, a stepped structure and a linear structure from the proximal end to the distal end, respectively, and the lengths of the three sections are 80-160 cm, 20-40 cm, 4-8 cm, respectively, and the tube body is composed of multiple layers.
  • a single-cavity tubular body having a structure consisting of a smooth layer composed of a polymer material from the inside to the outside, a support layer reinforcing layer woven and/or entangled with metal and/or polymer, and different hardnesses The polymer material is extruded or bonded along a gradual hardness gradient to form a jacket layer.
  • the aneurysm surgical device in the embodiment of the present application is used for intracranial aneurysm surgery, and those skilled in the art should know that it is only necessary to change the size of the aneurysm surgical device, and the aneurysm surgical device can also be used for celiac aneurysm surgery or the like. These improvements should also be considered within the scope of this application for aneurysm surgery at the site.
  • the aneurysm operation is performed using the above aneurysm surgical device.
  • the microcatheter 4 is first transported from the surgical wound into the blood vessel, and the microcatheter 4 is placed according to the developing position of the developing member 4-4 disposed under the X-ray.
  • the distal end of the tubular body 4-1 is delivered to the vicinity of the vascular lesion, and an axial direction force is applied to the delivery guide wire 2, and is bound to the outside of the delivery guide wire 2, and the stent 1 compressed in the introduction sheath 3 is introduced from the introduction sheath 3.
  • the medium is transported into the microcatheter, and the developing position of the spring element 2-2, the boss 2-3, and the transport positioning member 2-4 on the guide wire 2 is transported under X-ray, and the stent 1 is transported to the lesion of the blood vessel, as shown in the figure. 9 is shown.
  • the process of releasing the stent as shown in Fig.
  • the 10 can first push the guide wire 2, release the front end of the stent 1, and then withdraw a microcatheter 4, followed by pushing and withdrawing; As shown in Fig. 1, when releasing, the microcatheter 4 can be withdrawn first, the front end of the stent 1 is released, and the delivery guide wire 2 is pushed, and then the side is pushed and pushed. Both of these release methods can release the stent 1 to the lesion of the blood vessel. The difference between the two release modes is that the distal end of the microcatheter 4 has a different distance from the aneurysm opening before the stent 1 is released.
  • the positioning of the stent 1 may also be inaccurate, so that the stent 1 does not have a uniform hook covering the neck of the hemangioma, and the mesh of the guide wire 2 through the friction and/or the stent 1 can be utilized.
  • the angular position of the transport positioning member 2-4 is adjusted to adjust the position of the positioning bracket 1.
  • One way is to keep the delivery guidewire 2 in place and slowly push the microcatheter 4 so that the stent 1 slowly re-enters the microcatheter 4.
  • the position of the microcatheter 4 is kept fixed, and the delivery guide wire 2 is slowly withdrawn backward, and the stent 1 is slowly re-entered into the microcatheter 4.
  • the stent 1 is repositioned and released.
  • the stent in the aneurysm surgical device of the embodiment of the present application can also be supported or blocked as an embolic material (such as a detachable coil, a plugging liquid, etc.) in the aneurysm to ensure the embolic material. Only in the aneurysm, maintain the patency of the tumor-bearing artery, and assist in the treatment of vascular aneurysms.
  • an embolic material such as a detachable coil, a plugging liquid, etc.
  • the stent in the aneurysm surgical device of the embodiment of the present application has a high-density mesh structure, so that the stent has a high coverage, especially a high coverage and an uneven grid structure on the stent near the aneurysm, so that the released
  • the stent which is equivalent to reconstructing the arterial wall at the vascular lesion, significantly changes the direction of blood flow in the lesion, avoids the impact of blood on the inner wall of the aneurysm, and thus achieves the purpose of treating vascular aneurysms.
  • the dense mesh of the scaffold acts as a support for the growth or migration of vascular endothelial cells, accelerates the growth of the intima near the aneurysm, and causes the endometrialization of the lesion to achieve a true anatomy to cure the aneurysm.
  • the stent is bound to the delivery guide wire, and the stent and the delivery guide wire are pre-installed in the introduction sheath.
  • the micro catheter is first inserted into the disease.
  • the introducer sheath is connected to the microcatheter.
  • the stent bound to the delivery guidewire can be transported from the introducer sheath into the microcatheter and moved to the vascular lesion.
  • the stent is finally positioned and released into the lesion of the blood vessel.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Prostheses (AREA)
  • Surgical Instruments (AREA)

Description

一种动脉瘤手术装置 技术领域
本申请涉及医疗器械领域， 特别是涉及一种动脉瘤手术装置。 背景技术
动脉瘤是由于动脉血管壁因发生疾病、 损伤或先天性因素引起的 血管壁局部变得薄弱， 在血流的冲击下， 血管壁的薄弱点向外突出逐 渐扩张而形成。 动脉瘤可发生在身体的不同部位， 最常见为腹主动脉 瘤和颅内动脉瘤。 动脉瘤治疗的目标是减少动脉瘤破裂的风险， 最根 本的方法是实现母体载瘤动脉的愈合， 动脉壁解剖结构的重构。 目前血管内介入治疔动脉瘤的主要是采用支架辅助弹簧圈的方 法， 即将密度合适的支架输送到病变血管内， 然后再将弹簧圈从支架 的孔隙输送到动脉瘤内， 通过填塞动脉瘤达到治疗目的。 由于动脉瘤填塞治疗的终端行为发生在动脉瘤腔内， 通过对现有 技术研究， 申请人发现采用现有的支架辅助弹簧圈在治疗动脉瘤的过 程中， 弹簧圈存在占位效应， 出现瘤周脑组织、 重要血管和神经压迫 症状， 同时弹簧圏填塞完全致密闭塞率低， 术后复发、 再发率高。 另 外弹簧圈头端极易刺破较薄的动脉瘤壁， 会引发动脉瘤破裂， 直接导 致患者术中或术后死亡。 发明内容
鉴于以上技术问题， 本申请实施例提供一种动脉瘤手术装置， 技 术方案如下：
一种动脉瘤手术装置， 包括： 支架、 输送导丝、 导入鞘、 微导管， 其中- 所述支架为自膨式支架； 所述输送导丝设置在所述导入鞘内腔中， 且其外部束缚有所述支 架；
所述导入鞘与所述微导管相连， 内腔相通， 形成将所述输送导丝 和所述支架输送进入人体的通道。 优选地， 所述自膨式支架是由具有生物相容性的金属丝链和 /或聚 合物丝链编织而成。 优选地， 所述自膨式支架的结构为网管状结构。 优选地，所述网管状结构径向方向的压缩比在 1 : 2〜1： 10范围内。 优选地， 所述网管状结构是均匀网格结构。 优选地， 所述均匀网格结构的覆盖率在 20%〜60%范围内。 优选地， 所述均匀网格结构的覆盖率在 30%~50%范围内。 优选地， 所述网管状结构在动脉瘤位置处轴向方向和 /或径向方向 为不均匀网格结构， 其余部位为均匀网格结构。 优选地， 所述不均匀网格结构的覆盖率在 40%~60%范围内。 优选地， 所述均匀网格结构的覆盖率在 20%〜40%范围内。 优选地， 所述输送导丝包括：
金属芯， 用于输送并支撑所述支架；
弹簧元件， 覆盖在所述金属芯上；
凸台， 固定在所述金属芯上， 用于输送时给所述支架提供推力； 多个输送定位元件， 固定在所述弹簧元件或金属芯的外表面， 用 于输送时给所述支架提供推力或回收力。 优选地， 所述弹簧元件、 凸台和输送元件的材料为显影材料。 优选地， 所述导入鞘的结构为中空结构。 优选地， 所述导入鞘的材料为高分子材料。 优选地， 所述高分子材料为 PTFE材料、 HDFE材料或 FEP材料。 优选地， 所述微导管包括：
管体， 结构为直径从近端到远端逐渐减小、 硬度从近端到远端逐 渐减小的阶梯状中空结构；
应力扩散管， 一端与所述管体连接， 用于防止所述管体近端发生 打折；
连接件， 与所述应力扩散管的另一端连接， 且所述导入鞘插在其 中， 用于连接所述导入鞘和所述管体。 优选地， 所述管体的材料由内到外分别为： 光滑层、 加强层和外 套层， 其材料分别为高分子材料、 金属和 /或聚合物、 高分子材料。 优选地， 所述管体远端还设置有显影元件， 用于显示所述微导管 在血管中位置。 由以上本申请实施例提供的技术方案可见， 本申请实施例动脉瘤 手术装置中的支架具有高密度网格结构， 使支架有较高覆盖率， 尤其 是在动脉瘤附近的支架上的高覆盖率、 不均匀网格结构， 使释放后的 支架， 在血管病变处相当于重构了动脉壁， 显著地改变了病变处血流 流动方向， 避免了血液对动脉瘤内壁的冲击， 进而达到治疗血管动脉 瘤的目的。 同时支架的密网丝作为血管内皮细胞生长或移行的支撑， 加速实现动脉瘤口附近内膜的生长， 使病变处血管内膜化， 实现真正 的解剖治愈动脉瘤。 本申请实施例动脉瘤手术装置， 支架束缚在输送导丝上， 支架和 输送导丝预安装在导入鞘内， 在手术输送时， 首先将微导管插入到病 变血管处， 再把导入鞘与微导管相连， 通过向输送导丝施加轴向方向 的力， 可以将束缚在输送导丝上的支架从导入鞘输送至微导管中， 并 移动至血管病变处， 通过调整输送导丝和微导管的相对位置， 最后对 支架定位并将其释放到血管的病变处。 另外本申请实施例动脉瘤手术装置中的支架被输送释放到血管病 变处后， 还可以作为动脉瘤内的栓塞物质 （如可解脱弹簧圈、 栓塞液 体等） 支撑或遮挡， 以保证栓塞材料只处于动脉瘤内， 维持载瘤动脉 的通畅， 辅助治疗血管动脉瘤。 附图说明
为了更清楚地说明本申请实施例或现有技术中的技术方案， 下面 将对实施例或现有技术描述中所需要使用的附图作简单地介绍， 显而 易见地， 下面描述中的附图仅仅是本申请中记载的一些实施例， 对于 本领域普通技术人员来讲， 在不付出创造性劳动的前提下， 还可以根 据这些附图获得其他的附图。 图 1为本申请实施例提供的一种动脉瘤手术装置结构示意图； 图 2为本申请实施例提供的一种动脉瘤手术装置的局部剖视图； 图 3为本申请实施例支架的结构示意图；
图 4为本申请实施例支架的压缩示意图；
图 5为本申请实施例支架的网管状结构的平面示意图； 图 6为本申请实施例输送导丝的结构示意图；
图 7为本申请实施例输送导丝的凸台和输送元件的结构示意图； 图 8为本申请实施例微导管的结构示意图； 图 9为本申请实施例支架被输送到血管病变处的示意图； 图 10为本申请实施例利用边推边撤方式释放支架的示意图； 图 11为本申请实施例利用边撤边推方式释放支架的示意图。 具体实施方式
动脉瘤治疗的最根本的方法是： 实现母体载瘤动脉的愈合， 动脉 壁解剖结构的重构。 而现有的利用外科支架辅助弹簧圈的血管介入治 疗方法， 在动脉瘤治疗过程中存在占位效应、 栓塞不致密以及术中或 术后动脉瘤破裂的风险。 本申请实施例提供一种动脉瘤手术装置， 能够将高密度且超柔软 的支架输送到血管病变处并释放， 支架在血管病变处的网格结构具有 较高覆盖率， 使得释放进入血管的支架起到与载瘤血管愈合同样的效 果， 能够更好地治疗血管动脉瘤。 以上是本申请的核心思想， 为了使本技术领域的人员更好地理解 本申请中的技术方案， 下面将结合本申请实施例中的附图， 对本申请 实施例中的技术方案进行清楚、 完整地描述， 显然， 所描述的实施例 仅仅是本申请一部分实施例， 而不是全部的实施例。 基于本申请中的 实施例， 本领域普通技术人员在没有做出创造性劳动前提下所获得的 所有其他实施例， 都应当属于本申请保护的范围。 本申请实施例提供的一种动脉瘤手术装置。 图 1为该动脉瘤手术装置的外部结构示意图， 图 2为该手术血管 装置的局部剖视图。结合图 1和图 2， 该动脉瘤手术装置包括： 支架 1、 输送导丝 2、 导入鞘 3和微导管 4。 支架 1束缚在输送导丝 2远端的外部， 用于支撑病变血管； 输送 导丝 2设置在导入鞘 3的内部， 用于输送所述支架； 导入鞘 3用于预 装支架 1和输送导丝 2， 导入鞘 3的远端与微导管 4相连， 用于将输送 导丝 2和支架 1输送到微导管 4中；微导管 4用于输送时给输送导丝 2 和支架 1提供通道进入病变血管。 支架 1 为一种高度柔软和灵活的自膨式支架， 具有高密集度的连 续的网管状结构。 支架 1是由具有生物相容的金属丝链和 /或聚合物丝 链编织而成， 如图 3 所示， 网管状结构的每一个丝链与径向方向的编 织角为 , 角的范围在 15度〜 85度之间， 以保证支架 1在径向方向 和环向方向上有足够的支撑力。 如图 3 所示， 轴向方向上连续的丝链 1-1以丝链编织点 1-2为中心转动， 可以使支架 1具有足够的灵活性， 在空间上实现弯曲或扭转， 使其释放到血管中后， 更加接近自然血管 的形态， 能够顺应迂曲的脑血管， 同时还能支撑血管的管腔形态。 如 图 4所示， 支架 1 的上述可变结构， 使得其还具有高的可压缩比例， 其压縮比例可以达到 1 : 2-1： 10范围内， 压缩后的支架 1可以被装入 管径为 0.3mm~1.5mm的导入鞘或微导管内。 支架 1的网管状结构可以是全部均匀的连续网格， 如图 5 ( a) 所 示，均勾的连续网格的覆盖率在 20%〜60%范围内，在本申请实施例中， 均匀的连续网格的覆盖率选择在 30%~50%之间。 另外支架 1的网管状 结构还可以为在动脉瘤位置处轴向方向和 /或径向方向为不均匀网格结 构， 其余部位为均匀网格结构。 如图 5 ( b ) 所示， 不均匀的连续网格 输送到血管中后， 输送到动脉瘤口面或动脉瘤口附近的血管区域， 在 这里的网格覆盖率也是最高的， 达到 40%〜60%， 这么高的覆盖率可以 在最大限度内改变动脉瘤内的血流。 其余部位均匀的连续网格的覆盖 率较低，在 20%〜40%之间， 以保证能够支撑动脉瘤附近正常的血管壁， 使载瘤动脉的管腔畅通， 同时也尽可能减少对载瘤动脉分支血管的覆 盖面积， 不会影响载瘤动脉流入分支血管的血流量。 如图 6所示， 输送导丝 2包括： 金属芯 2-1、 弹簧元件 2-2、 凸台 2-3和多个输送定位件 2-4， 其中： 金属芯 2-1 的结构为从近端到远端 依次为直线状结构、 直径逐渐减小阶梯状结构和直线状结构， 用于输 送并支撑支架 1。 弹簧元件 2-2， 覆盖在金属芯 2-1的远端直线状结构 和中间阶梯状结构上。 凸台 2-3， 固定在金属芯 2-1上， 用于输送时给 支架 1提供推力。 多个输送定位元件 2-4， 固定在弹簧元件 2-2或金属 芯 2-1的外表面， 位置在凸台 2-3之前， 用于输送时给支架 1提供推力 或回收力。 金属芯 2-1 的材料可以选择不锈钢、 镍钛合金、 铜合金、 铝合金 等， 并且金属芯 2-1可以有一种材料研磨而成， 还可以由两种材料粘结 或焊接而成， 其直径根据血管的迂曲程度， 通常从直径为 0.025~0.012 英寸的近端直线状结构逐渐减小到直径为 0.012〜0.002英寸的远端直线 状结构， 其近端直线状结构长度可以在 1500~2000mm范围内， 中间阶 梯状结构的长度可以在 300~500mm范围内， 远端直线状结构的长度可 以在 10~30mm范围内。 如图 7 ( a)所示， 凸台 2-3结构为金属圆环片。 如图 7 ( b)所示， 输送元件 2-4的形状为外侧设置有 4个圆润棱角多边形，其设置个数根 据支架 1 的长度来确定， 输送时， 输送元件 2-4通过棱角摩擦和 /或嵌 入支架 1 的网格中来带动支架 1 向前或向后运动。 本申请实施例中， 输送元件 2-4为 4个。 弹簧元件 2-2、 凸台 2-3和输送定位元件 2-4的材料选择可以显影 的坦、 铂金、 黄金、 钨或显影的高分子聚合物等材料。 导入鞘 3为中空结构的高分子管材， 具有较低的摩擦系数， 其材 料可以为 PTFE材料、 HDPE材料、 FEP材料等。 压縮并束缚在输送导 丝 2上的支架 1通常预先装载在导入鞘 3中， 在输送时， 通过输送导 丝 2将支架 1从导入鞘 3中推送到微导管 4中。 如图 8所示， 微导管 4包括： 管体 4-1、 应力扩散管 4-2、 连接件 4-3和显影元件 4-4， 其中： 管体 4-1 的结构为直径从近端到远端逐渐 减小、 硬度从近端到远端逐渐减小的阶梯状中空结构。 应力扩散管 4-2 的一端与管体 4-1连接， 用于防止管体 4-1近端发生打折或弯曲。 连接 件 4-3与应力扩散管 4-2的另一端连接， 且导入鞘 3插入在其中， 用于 连接导入鞘 3和管体 4-1， 显影元件 4-4设置在管体 4-1的远端， 用于 手术时显示微导管 4在血管中的位置。 管体 4-1 在轴向方向上根据血管的迂曲程度和血管大小， 具有不 同的结构、 不同的硬度和不同的直径。 其中， 结构从近端到远端分别 为直线状结构、 阶梯状结构和直线状结构， 这三段结构的长度依次分 别为 80~160cm、 20〜40cm、 4~8cm， 管体是由多层结构组成的单腔管 体， 多层结构由内到外依次为有高分子材料复合而成的光滑层、 由金 属和 /或聚合物编织和 /或缠绕而成支撑层加强层和由不同硬度的高分 子材料沿渐变的硬度梯度挤出或粘结而成的外套层。 本申请实施例中的动脉瘤手术装置用于颅内动脉瘤手术， 本领域 技术人员应该知道， 只需改变动脉瘤手术装置的尺寸， 该动脉瘤手术 装置还可以用于腹腔动脉瘤手术或其它部位的动脉瘤手术中， 这些改 进也应视为在本申请的保护范围。 使用上述动脉瘤手术装置进行动脉瘤手术， 输送过程中， 首先将 微导管 4从手术创口输送到血管内，根据其上设置的显影元件 4-4在 X 光下的显影位置， 将微导管 4的管体 4-1的远端输送到血管病变附近， 对输送导丝 2施加轴向方向的力， 将束缚在输送导丝 2的外部、 压缩 在导入鞘 3内的支架 1从导入鞘 3中输送到微导管中， 根据 X光下输 送导丝 2上弹簧元件 2-2、 凸台 2-3、 和输送定位件 2-4显影位置， 将 支架 1输送到血管的病变处， 如图 9所示。 释放支架的过程， 如图 10所示， 可以先推送导丝 2， 使支架 1的 前端释放， 再撤回一段微导管 4， 之后依次为边推边撤的方式； 如图 1 1所示， 释放时还可以先撤回一段微导管 4， 使支架 1 的前端释放， 再推送输送导丝 2， 之后依次为边撤边推的方式。这两种释放方式都可 以将支架 1 释放到血管的病变处， 两种释放方式的不同之处在于， 支 架 1释放之前微导管 4的远端与动脉瘤口的距离不同。 在释放过程中， 还会出现支架 1的定位不准确， 使得支架 1没有 均勾覆盖在血管瘤的瘤颈位置， 这时可以利用输送导丝 2 上通过摩擦 和 /或嵌入支架 1 的网格中的输送定位件 2-4的棱角来调整定位支架 1 的位置。 一种方式是保持输送导丝 2位置固定， 缓慢推动微导管 4， 使 得支架 1缓慢的重新进入微导管 4中。 另一种方式则保持微导管 4位 置固定， 缓慢向后撤动输送导丝 2， 带动支架 1缓慢的重新进入微导管 4中。通过上述两种方式中任一种方式， 在支架 1重新进入微导管 4中 之后， 将支架 1重新定位并释放。 另外， 本申请实施例动脉瘤手术装置中的支架被输送释放到血管 病变处后， 还可以作为动脉瘤内的栓塞物质 （如可解脱弹簧圈、 栓塞 液体等） 支撑或遮挡， 以保证栓塞材料只处于动脉瘤内， 维持载瘤动 脉的通畅， 辅助治疗血管动脉瘤。
本申请实施例动脉瘤手术装置中的支架具有高密度网格结构， 使 支架有较高覆盖率， 尤其是在动脉瘤附近的支架上的高覆盖率、 不均 匀网格结构， 使释放后的支架， 在血管病变处相当于重构了动脉壁， 显著地改变了病变处血流流动方向， 避免了血液对动脉瘤内壁的冲击， 进而达到治疗血管动脉瘤的目的。 同时支架的密网丝作为血管内皮细 胞生长或移行的支撑， 加速实现动脉瘤口附近内膜的生长， 使病变处 血管内膜化， 实现真正的解剖治愈动脉瘤。 本申请实施例动脉瘤手术装置， 支架束缚在输送导丝上， 支架和 输送导丝预安装在导入鞘内， 在手术输送时， 首先将微导管插入到病 变血管处， 再把导入鞘与微导管相连， 通过向输送导丝施加轴向方向 的力， 可以将束缚在输送导丝上的支架从导入鞘输送至微导管中， 并 移动至血管病变处， 通过调整输送导丝和微导管的相对位置， 最后对 支架定位并将其释放到血管的病变处。 以上所述仅是本申请的具体实施方式， 应当指出， 对于本技术领 域的普通技术人员来说， 在不脱离本申请原理的前提下， 还可以做出 若干改进和润饰， 这些改进和润饰也应视为本申请的保护范围。

Claims

1. 一种动脉瘤手术装置， 其特征在于， 包括： 支架、 输送导丝、 导入鞘、 微导管， 其中- 所述支架为自膨式支架；
所述输送导丝设置在所述导入鞘内腔中， 且其外部束缚有所述支 架；
所述导入鞘与所述微导管相连， 内腔相通， 形成将所述输送导丝 和所述支架输送进入人体的通道。
2. 根据权利要求 1所述的装置， 其特征在于， 所述自膨式支架是 由具有生物相容性的金属丝链和 /或聚合物丝链编织而成。
3. 根据权利要求 2所述的装置， 其特征在于， 所述自膨式支架的 结构为网管状结构。
4. 根据权利要求 3所述的装置， 其特征在于， 所述网管状结构径 向方向的压缩比在 1 : 2-1： 10范围内。
5. 根据权利要求 4所述的装置， 其特征在于， 所述网管状结构是 均匀网格结构。
6. 根据权利要求 5所述的装置， 其特征在于， 所述均匀网格结构 的覆盖率在 20%〜60%范围内。
7. 根据权利要求 6所述的装置， 其特征在于， 所述均匀网格结构 的覆盖率在 30%〜50%范围内。
8. 根据权利要求 4所述的装置， 其特征在于， 所述网管状结构在 动脉瘤位置处轴向方向和 /或径向方向为不均勾网格结构， 其余部位为 均勾网格结构。
9. 根据权利要求 8所述的装置， 其特征在于， 所述不均匀网格结 构的覆盖率在 40%~60%范围内。
10. 根据权利要求 8 所述的装置， 其特征在于， 所述均匀网格结 构的覆盖率在 20%~40%范围内。
11. 根据权利要求 1 所述的装置， 其特征在于， 所述输送导丝包 括- 金属芯， 用于输送并支撑所述支架；
弹簧元件， 覆盖在所述金属芯上；
凸台， 固定在所述金属芯上， 用于输送时给所述支架提供推力； 多个输送定位元件， 固定在所述弹簧元件或金属芯的外表面， 用 于输送时给所述支架提供推力或回收力。
12. 根据权利要求 1 1所述的装置， 其特征在于， 所述弹簧元件、 凸台和输送元件的材料为显影材料。
13. 根据权利要求 1 所述的装置， 其特征在于， 所述导入鞘的结 构为中空结构。
14. 根据权利要求 13所述的装置， 其特征在于， 所述导入鞘的材 料为高分子材料。
15. 根据权利要求 14所述的装置， 其特征在于， 所述高分子材料 为 PTFE材料、 HDFE材料或 FEP材料。
16. 根据权利要求 1所述的装置， 其特征在于， 所述微导管包括: 管体， 结构为直径从近端到远端逐渐减小、 硬度从近端到远端逐 渐减小的阶梯状中空结构；
应力扩散管， 一端与所述管体连接， 用于防止所述管体近端发生 打折；
连接件， 与所述应力扩散管的另一端连接， 且所述导入鞘插在其 中， 用于连接所述导入鞘和所述管体。
17. 根据权利要求 16所述的装置， 其特征在于， 所述管体的材料 由内到外分别为： 光滑层、 加强层和外套层， 其材料分别为高分子材 料、 金属和 /或聚合物、 高分子材料。
18. 根据权利要求 17所述的装置， 其特征在于， 所述管体远端还 设置有显影元件， 用于显示所述微导管在血管中位置。
PCT/CN2011/071447 2010-03-02 2011-03-02 一种动脉瘤手术装置 WO2011107024A1 (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1020127022741A KR101498531B1 (ko) 2010-03-02 2011-03-02 동맥류 수술장치
US13/581,728 US20130066413A1 (en) 2010-03-02 2011-03-02 Surgical apparatus for aneurysms
EP11750177.5A EP2543345B1 (en) 2010-03-02 2011-03-02 Surgical apparatus for aneurysms
ES11750177T ES2697513T3 (es) 2010-03-02 2011-03-02 Aparato quirúrgico para aneurismas
JP2012555290A JP5814949B2 (ja) 2010-03-02 2011-03-02 動脈瘤手術装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201010116448.1 2010-03-02
CN201010116448.1A CN102188300B (zh) 2010-03-02 2010-03-02 一种动脉瘤手术装置

Publications (1)

Publication Number Publication Date
WO2011107024A1 true WO2011107024A1 (zh) 2011-09-09

Family

ID=44541660

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2011/071447 WO2011107024A1 (zh) 2010-03-02 2011-03-02 一种动脉瘤手术装置

Country Status (8)

Country Link
US (1) US20130066413A1 (zh)
EP (1) EP2543345B1 (zh)
JP (1) JP5814949B2 (zh)
KR (1) KR101498531B1 (zh)
CN (1) CN102188300B (zh)
ES (1) ES2697513T3 (zh)
TR (1) TR201815773T4 (zh)
WO (1) WO2011107024A1 (zh)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108245293A (zh) * 2018-01-22 2018-07-06 苏州恒瑞迪生医疗科技有限公司 一种长规格血管支架输送系统
CN112690854A (zh) * 2020-12-30 2021-04-23 广州易介医疗科技有限公司 一种血流重建支架的输送系统
CN113925556A (zh) * 2021-11-03 2022-01-14 聚辉医疗科技(深圳)有限公司 栓塞弹簧圈系统
CN114748226A (zh) * 2022-04-24 2022-07-15 上海心玮医疗科技股份有限公司 一种血流导向装置

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10028747B2 (en) 2008-05-01 2018-07-24 Aneuclose Llc Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm
US10716573B2 (en) 2008-05-01 2020-07-21 Aneuclose Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm
US9358140B1 (en) 2009-11-18 2016-06-07 Aneuclose Llc Stent with outer member to embolize an aneurysm
CN102871700B (zh) * 2012-10-09 2015-04-29 加奇生物科技(上海)有限公司 用于栓塞动脉瘤的编织体系统
DE102013014523A1 (de) 2013-09-03 2015-03-05 Phenox Gmbh Einführ- und Ablösesystem für Implantate
US11154302B2 (en) 2014-03-31 2021-10-26 DePuy Synthes Products, Inc. Aneurysm occlusion device
US11076860B2 (en) 2014-03-31 2021-08-03 DePuy Synthes Products, Inc. Aneurysm occlusion device
ES2732752T3 (es) 2014-04-30 2019-11-25 Cerus Endovascular Ltd Dispositivo de oclusión
US9918718B2 (en) 2014-08-08 2018-03-20 DePuy Synthes Products, Inc. Embolic coil delivery system with retractable mechanical release mechanism
JP2016073553A (ja) 2014-10-08 2016-05-12 朝日インテック株式会社 プッシャーガイドワイヤ
JP2016077765A (ja) 2014-10-22 2016-05-16 朝日インテック株式会社 ガイドワイヤ
KR101613269B1 (ko) 2014-11-19 2016-04-29 재단법인 아산사회복지재단 혈관내 의료용 부재 이송 장치
JP6400448B2 (ja) 2014-11-29 2018-10-03 株式会社Ｐｅｎｔａｓ ステントデリバリーシステム
EP3078350B1 (en) * 2015-04-09 2018-01-31 Frid Mind Technologies 3d filter for prevention of stroke
WO2017053784A1 (en) * 2015-09-25 2017-03-30 Covidien Lp Medical device delivery system
CN105193532A (zh) * 2015-10-30 2015-12-30 加奇生物科技（上海）有限公司苏州分公司 颈动脉支架系统
US10285711B2 (en) 2015-12-07 2019-05-14 Cerus Endovascular Limited Occlusion device
WO2017153603A1 (en) 2016-03-11 2017-09-14 Cerus Endovascular Limited Occlusion device
CN108056798B (zh) * 2016-11-08 2021-06-04 艾柯医疗器械(北京)有限公司 支架推送系统以及对应的血流导向装置和血流导向装置装配方法
KR20190115474A (ko) 2017-02-23 2019-10-11 디퍼이 신테스 프로덕츠, 인코포레이티드 동맥류 장치 및 전달 시스템
IL272716B2 (en) 2017-08-21 2023-09-01 Cerus Endovascular Ltd Install a block
US10806462B2 (en) 2017-12-21 2020-10-20 DePuy Synthes Products, Inc. Implantable medical device detachment system with split tube and cylindrical coupling
US10905430B2 (en) 2018-01-24 2021-02-02 DePuy Synthes Products, Inc. Aneurysm device and delivery system
US11596412B2 (en) 2018-05-25 2023-03-07 DePuy Synthes Products, Inc. Aneurysm device and delivery system
US11058430B2 (en) 2018-05-25 2021-07-13 DePuy Synthes Products, Inc. Aneurysm device and delivery system
US10939915B2 (en) 2018-05-31 2021-03-09 DePuy Synthes Products, Inc. Aneurysm device and delivery system
US11051825B2 (en) 2018-08-08 2021-07-06 DePuy Synthes Products, Inc. Delivery system for embolic braid
US11123077B2 (en) 2018-09-25 2021-09-21 DePuy Synthes Products, Inc. Intrasaccular device positioning and deployment system
US11076861B2 (en) 2018-10-12 2021-08-03 DePuy Synthes Products, Inc. Folded aneurysm treatment device and delivery method
US11406392B2 (en) 2018-12-12 2022-08-09 DePuy Synthes Products, Inc. Aneurysm occluding device for use with coagulating agents
US11147562B2 (en) * 2018-12-12 2021-10-19 DePuy Synthes Products, Inc. Systems and methods for embolic implant detachment
US11272939B2 (en) 2018-12-18 2022-03-15 DePuy Synthes Products, Inc. Intrasaccular flow diverter for treating cerebral aneurysms
US11134953B2 (en) 2019-02-06 2021-10-05 DePuy Synthes Products, Inc. Adhesive cover occluding device for aneurysm treatment
AU2020242051A1 (en) 2019-03-20 2021-11-04 inQB8 Medical Technologies, LLC Aortic dissection implant
US11337706B2 (en) 2019-03-27 2022-05-24 DePuy Synthes Products, Inc. Aneurysm treatment device
CN109965930B (zh) * 2019-04-29 2024-05-31 北京久事神康医疗科技有限公司 一种动脉瘤栓塞装置及动脉瘤栓塞系统
US11497504B2 (en) 2019-05-21 2022-11-15 DePuy Synthes Products, Inc. Aneurysm treatment with pushable implanted braid
US11278292B2 (en) 2019-05-21 2022-03-22 DePuy Synthes Products, Inc. Inverting braided aneurysm treatment system and method
US11607226B2 (en) 2019-05-21 2023-03-21 DePuy Synthes Products, Inc. Layered braided aneurysm treatment device with corrugations
US11672542B2 (en) 2019-05-21 2023-06-13 DePuy Synthes Products, Inc. Aneurysm treatment with pushable ball segment
US10653425B1 (en) 2019-05-21 2020-05-19 DePuy Synthes Products, Inc. Layered braided aneurysm treatment device
US11602350B2 (en) 2019-12-05 2023-03-14 DePuy Synthes Products, Inc. Intrasaccular inverting braid with highly flexible fill material
US11413046B2 (en) 2019-05-21 2022-08-16 DePuy Synthes Products, Inc. Layered braided aneurysm treatment device
US11253265B2 (en) 2019-06-18 2022-02-22 DePuy Synthes Products, Inc. Pull wire detachment for intravascular devices
CN110169852B (zh) * 2019-07-01 2024-03-19 江苏暖阳医疗器械有限公司 一种自膨式支架的双导丝输送系统
US11207494B2 (en) 2019-07-03 2021-12-28 DePuy Synthes Products, Inc. Medical device delivery member with flexible stretch resistant distal portion
US11426174B2 (en) 2019-10-03 2022-08-30 DePuy Synthes Products, Inc. Medical device delivery member with flexible stretch resistant mechanical release
CN110507457B (zh) * 2019-08-30 2022-04-22 湖南瑞康通科技发展有限公司 一种支架、其输送系统及医疗器械
US11439403B2 (en) 2019-09-17 2022-09-13 DePuy Synthes Products, Inc. Embolic coil proximal connecting element and stretch resistant fiber
US11376013B2 (en) 2019-11-18 2022-07-05 DePuy Synthes Products, Inc. Implant delivery system with braid cup formation
CN110934661B (zh) * 2019-11-27 2023-01-03 张海军 一种用于治疗动脉瘤的可降解贴片及其输送方法
US11457926B2 (en) 2019-12-18 2022-10-04 DePuy Synthes Products, Inc. Implant having an intrasaccular section and intravascular section
US11457922B2 (en) 2020-01-22 2022-10-04 DePuy Synthes Products, Inc. Medical device delivery member with flexible stretch resistant distal portion
US11432822B2 (en) 2020-02-14 2022-09-06 DePuy Synthes Products, Inc. Intravascular implant deployment system
US11406404B2 (en) 2020-02-20 2022-08-09 Cerus Endovascular Limited Clot removal distal protection methods
US11951026B2 (en) 2020-06-30 2024-04-09 DePuy Synthes Products, Inc. Implantable medical device detachment system with flexible braid section
CN111888061B (zh) * 2020-09-04 2024-08-02 江苏暖阳医疗器械有限公司 一种血流导向支架输送系统
CN112741690B (zh) * 2020-12-31 2022-04-19 杭州脉流科技有限公司 用于血管支架释放的模拟方法、装置、计算机设备和存储介质
CN113041480A (zh) * 2021-04-22 2021-06-29 深圳麦普奇医疗科技有限公司 一种用于冠脉介入的导引导丝
US11998213B2 (en) 2021-07-14 2024-06-04 DePuy Synthes Products, Inc. Implant delivery with modified detachment feature and pull wire engagement
CN114451946A (zh) * 2021-08-23 2022-05-10 上海心玮医疗科技股份有限公司 一种输送导丝以及血流导向装置
CN113749834B (zh) * 2021-09-02 2024-08-13 上海励楷科技有限公司 一种支架递送系统
CN113827386B (zh) * 2021-11-29 2022-03-29 艾柯医疗器械(北京)有限公司 一种自膨式支架导入装置
US11937824B2 (en) 2021-12-30 2024-03-26 DePuy Synthes Products, Inc. Implant detachment systems with a modified pull wire
US11844490B2 (en) 2021-12-30 2023-12-19 DePuy Synthes Products, Inc. Suture linkage for inhibiting premature embolic implant deployment
US12011171B2 (en) 2022-01-06 2024-06-18 DePuy Synthes Products, Inc. Systems and methods for inhibiting premature embolic implant deployment
US11937825B2 (en) 2022-03-02 2024-03-26 DePuy Synthes Products, Inc. Hook wire for preventing premature embolic implant detachment
US11937826B2 (en) 2022-03-14 2024-03-26 DePuy Synthes Products, Inc. Proximal link wire for preventing premature implant detachment
CN114748123A (zh) * 2022-03-17 2022-07-15 上海心玮医疗科技股份有限公司 一种血流导向装置输送导丝远端自膨体结构
CN116725614B (zh) * 2023-08-16 2023-11-17 北京华脉泰科医疗器械股份有限公司 瘤腔内支架组

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2889337Y (zh) * 2006-02-16 2007-04-18 微创医疗器械(上海)有限公司 微导管
WO2009042789A2 (en) * 2007-09-26 2009-04-02 Trivascular2, Inc. Stent deployment devices and methods
CN101472536A (zh) * 2006-05-24 2009-07-01 切斯纳特医学技术公司 柔软的血管闭塞装置
US20090270974A1 (en) * 2004-05-25 2009-10-29 Chestnut Medical Technologies, Inc. Vascular stenting for aneurysms
CN201379671Y (zh) * 2009-01-19 2010-01-13 加奇生物科技(上海)有限公司 可回撤自弹式脑神经支架的输送装置
US7655031B2 (en) * 2006-04-28 2010-02-02 Codman & Shurtleff, Inc. Stent delivery system with improved retraction member
CN201625318U (zh) * 2009-12-18 2010-11-10 微创医疗器械(上海)有限公司 一种特殊显影元件及具有该特殊显影元件的导管

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11299901A (ja) * 1998-04-16 1999-11-02 Johnson & Johnson Medical Kk ステント及びその製造方法
JP4583597B2 (ja) * 1998-05-05 2010-11-17 ボストン サイエンティフィック リミテッド 末端が滑らかなステント
US6613075B1 (en) * 1999-10-27 2003-09-02 Cordis Corporation Rapid exchange self-expanding stent delivery catheter system
US20020177870A1 (en) * 2001-05-25 2002-11-28 Ivan Sepetka Single lumen balloon catheter
US7001422B2 (en) * 2002-09-23 2006-02-21 Cordis Neurovascular, Inc Expandable stent and delivery system
US8267985B2 (en) * 2005-05-25 2012-09-18 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
ES2607402T3 (es) * 2004-05-25 2017-03-31 Covidien Lp Dispositivo de oclusión vascular flexible
WO2006127005A1 (en) * 2005-05-25 2006-11-30 Chestnut Medical Technologies, Inc. System and method for delivering and deploying and occluding device within a vessel
US20070203563A1 (en) * 2006-02-13 2007-08-30 Stephen Hebert System for delivering a stent
CA2654703A1 (en) * 2006-07-07 2008-01-10 Boston Scientific Limited Endoprosthesis delivery system with stent holder
JP5134729B2 (ja) * 2008-07-01 2013-01-30 エンドロジックス、インク カテーテルシステム
CN101779992B (zh) * 2009-01-19 2012-08-22 加奇生物科技(上海)有限公司 可回撤自弹式脑神经支架的输送装置
CN102145202B (zh) * 2010-02-05 2012-12-26 微创医疗器械(上海)有限公司 一种医用导丝
CN202889337U (zh) * 2012-10-30 2013-04-17 张乃千 多功能的电子装置

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090270974A1 (en) * 2004-05-25 2009-10-29 Chestnut Medical Technologies, Inc. Vascular stenting for aneurysms
CN2889337Y (zh) * 2006-02-16 2007-04-18 微创医疗器械(上海)有限公司 微导管
US7655031B2 (en) * 2006-04-28 2010-02-02 Codman & Shurtleff, Inc. Stent delivery system with improved retraction member
CN101472536A (zh) * 2006-05-24 2009-07-01 切斯纳特医学技术公司 柔软的血管闭塞装置
WO2009042789A2 (en) * 2007-09-26 2009-04-02 Trivascular2, Inc. Stent deployment devices and methods
CN201379671Y (zh) * 2009-01-19 2010-01-13 加奇生物科技(上海)有限公司 可回撤自弹式脑神经支架的输送装置
CN201625318U (zh) * 2009-12-18 2010-11-10 微创医疗器械(上海)有限公司 一种特殊显影元件及具有该特殊显影元件的导管

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108245293A (zh) * 2018-01-22 2018-07-06 苏州恒瑞迪生医疗科技有限公司 一种长规格血管支架输送系统
CN108245293B (zh) * 2018-01-22 2024-03-19 苏州恒瑞宏远医疗科技有限公司 一种长规格血管支架输送系统
CN112690854A (zh) * 2020-12-30 2021-04-23 广州易介医疗科技有限公司 一种血流重建支架的输送系统
CN112690854B (zh) * 2020-12-30 2023-09-19 广州易介医疗科技有限公司 一种血流重建支架的输送系统
CN113925556A (zh) * 2021-11-03 2022-01-14 聚辉医疗科技(深圳)有限公司 栓塞弹簧圈系统
CN113925556B (zh) * 2021-11-03 2023-03-10 聚辉医疗科技(深圳)有限公司 栓塞弹簧圈系统
CN114748226A (zh) * 2022-04-24 2022-07-15 上海心玮医疗科技股份有限公司 一种血流导向装置

Also Published As

Publication number Publication date
CN102188300B (zh) 2014-05-28
EP2543345A4 (en) 2016-01-13
ES2697513T3 (es) 2019-01-24
KR101498531B1 (ko) 2015-03-04
KR20120123121A (ko) 2012-11-07
US20130066413A1 (en) 2013-03-14
EP2543345B1 (en) 2018-08-22
JP2013521022A (ja) 2013-06-10
TR201815773T4 (tr) 2018-11-21
JP5814949B2 (ja) 2015-11-17
CN102188300A (zh) 2011-09-21
EP2543345A1 (en) 2013-01-09

Similar Documents

Publication Publication Date Title
WO2011107024A1 (zh) 一种动脉瘤手术装置
US11564817B2 (en) Procedures for vascular occlusion
JP4980370B2 (ja) 腹部大動脈瘤を補強するための血管内送達が可能なステント
US7063719B2 (en) Stent devices with detachable distal or proximal wires
JP6317678B2 (ja) 医学的治療を支援するための装置及び方法
US20160095728A1 (en) Vascular stenting for aneurysms
KR20150092277A (ko) 의학적 치료를 보조하기 위한 장치
US8945207B2 (en) Removable stent and method of production
WO2021128937A1 (zh) 支架输送系统及装载支架的方法
AU2005286780A1 (en) Variable flexibility wire guide
US9456913B2 (en) Implant introducer with helical trigger wire
JP2022525788A (ja) 大動脈解離インプラント
CA2820405C (en) Removable stent and method of production
US20060085028A1 (en) Vessel occlusion system
JPH09154949A (ja) 医療用挿入装置
JP2011504778A (ja) 治療薬剤の送達のためのカテーテルベース医療デバイスおよび方法
CN118203381A (zh) 封堵系统及封堵装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11750177

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2012555290

Country of ref document: JP

ENP Entry into the national phase

Ref document number: 20127022741

Country of ref document: KR

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2011750177

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 8305/DELNP/2012

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 13581728

Country of ref document: US