WO2010147434A2 - 투센다닌 또는 멀구슬나무 추출물의 치매 예방 또는 치료를 위한 용도 - Google Patents

투센다닌 또는 멀구슬나무 추출물의 치매 예방 또는 치료를 위한 용도 Download PDF

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Publication number
WO2010147434A2
WO2010147434A2 PCT/KR2010/003971 KR2010003971W WO2010147434A2 WO 2010147434 A2 WO2010147434 A2 WO 2010147434A2 KR 2010003971 W KR2010003971 W KR 2010003971W WO 2010147434 A2 WO2010147434 A2 WO 2010147434A2
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WO
WIPO (PCT)
Prior art keywords
preventing
treating dementia
extracts
toosendanin
melia azedarach
Prior art date
Application number
PCT/KR2010/003971
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English (en)
French (fr)
Other versions
WO2010147434A3 (ko
Inventor
최진성
유종수
유영상
김영재
박은경
유정수
연승우
강재훈
Original Assignee
일동제약주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 일동제약주식회사 filed Critical 일동제약주식회사
Priority to CN201080027324.4A priority Critical patent/CN102458414B/zh
Priority to ES10789761.3T priority patent/ES2483736T3/es
Priority to JP2012515994A priority patent/JP5650731B2/ja
Priority to EP10789761.3A priority patent/EP2444091B1/en
Publication of WO2010147434A2 publication Critical patent/WO2010147434A2/ko
Publication of WO2010147434A3 publication Critical patent/WO2010147434A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Mycology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

본 발명은 투센다닌 또는 멀구슬나무 추출물을 유효성분으로 함유하는 치매 예방 도는 치료용 조성물에 관한 것으로서, 보다 상세하게는 투센다닌 또는 멀구슬나무 추출물을 유효성분으로 함유하는 치매 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명의 멀구슬나무 추출물 또는 투센다닌 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 약학적 조성물, 이의 용도 및 치매 예방 또는 치료 방법은 치매 예방 또는 치료에 효과적이다. 특히 본 발명의 조성물, 용도 또는 방법은 베타아밀로이드 생성 억제 작용 및 신경세포 보호효과를 나타내는 APPa 생성 촉진을 유도하는 작용이 우수하여 알츠하이머병 같은 치매의 예방 또는 치료에 우수한 효능을 가진다.
PCT/KR2010/003971 2009-06-19 2010-06-18 투센다닌 또는 멀구슬나무 추출물의 치매 예방 또는 치료를 위한 용도 WO2010147434A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201080027324.4A CN102458414B (zh) 2009-06-19 2010-06-18 川楝素或楝树提取物在痴呆预防和治疗上的用途
ES10789761.3T ES2483736T3 (es) 2009-06-19 2010-06-18 Uso de toosendanina o extractos de melia azedarach para la prevención o tratamiento de la demencia
JP2012515994A JP5650731B2 (ja) 2009-06-19 2010-06-18 ツーセンダニン又はセンダン（栴檀）抽出物の痴呆の予防又は治療のための使用
EP10789761.3A EP2444091B1 (en) 2009-06-19 2010-06-18 Use of toosendanin or melia azedarach extracts for preventing or treating dementia

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090054949A KR101226660B1 (ko) 2009-06-19 2009-06-19 투센다닌 또는 멀구슬나무 추출물을 유효성분으로 함유하는 치매 예방 또는 치료용 조성물
KR10-2009-0054949 2009-06-19

Publications (2)

Publication Number Publication Date
WO2010147434A2 true WO2010147434A2 (ko) 2010-12-23
WO2010147434A3 WO2010147434A3 (ko) 2011-08-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/003971 WO2010147434A2 (ko) 2009-06-19 2010-06-18 투센다닌 또는 멀구슬나무 추출물의 치매 예방 또는 치료를 위한 용도

Country Status (6)

Country Link
EP (1) EP2444091B1 (ko)
JP (1) JP5650731B2 (ko)
KR (1) KR101226660B1 (ko)
CN (1) CN102458414B (ko)
ES (1) ES2483736T3 (ko)
WO (1) WO2010147434A2 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115177745A (zh) * 2022-08-11 2022-10-14 福建医科大学附属口腔医院 一种川楝素及其纳米材料复合物的制备方法和应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103675191B (zh) * 2013-12-24 2014-12-10 江西南昌制药有限公司 一种道地药材川楝子的检测方法
CN106243184B (zh) * 2016-07-28 2018-10-16 福建医科大学 一种楝苦素类四降三萜化合物和该化合物的提取分离方法以及应用
KR20180065720A (ko) * 2016-12-08 2018-06-18 이성현 멀구슬음료 제조방법
CN107028957B (zh) * 2017-05-08 2020-09-01 上海市第一人民医院 中药单体川楝素作为stat3抑制剂及其在制备抗骨肉瘤药物中的应用
CN107703294B (zh) * 2017-10-12 2019-06-04 华派生物工程集团有限公司 一种用于检测鸡血清中cLHRH抗体效价的ELISA方法
KR102594706B1 (ko) * 2022-04-14 2023-10-27 한국 한의학 연구원 한약재 추출물을 유효성분으로 포함하는 코로나바이러스 감염증의 예방, 개선 또는 치료용 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372239B1 (en) 2000-01-28 2002-04-16 Greentech, Inc. Compositions and methods for controlling pests using synergistic cocktails of plant alkaloids
KR100345226B1 (ko) 2001-08-29 2002-07-25 주식회사 태평양 천련자 추출물을 함유하는 미백용 화장료 조성물
US6866856B2 (en) 2002-12-31 2005-03-15 Avon Products, Inc. Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis
KR100750879B1 (ko) 2005-07-22 2007-08-22 건국대학교 산학협력단 고련피 추출물 및 이를 포함하는 알레르기 질환의 예방 및치료를 위한 약학조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58144320A (ja) * 1982-02-19 1983-08-27 Terumo Corp 抗腫瘍性多糖体およびその製造法
DE3305047A1 (de) * 1982-02-19 1983-09-22 Terumo Kabushiki Kaisha trading as Terumo Corp., Tokyo Polysaccharide, ihre herstellung und diese enthaltende therapeutische zusammensetzungen
CN1476829A (zh) * 2003-07-16 2004-02-25 中国科学院上海生命科学研究院 川楝素作为抗肿瘤药物的应用
KR20100011453A (ko) * 2008-07-25 2010-02-03 동국대학교 산학협력단 천련자 추출물을 유효성분으로 함유하는 산화적 스트레스에의한 질환 및 염증성 질환의 예방 및 치료용 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372239B1 (en) 2000-01-28 2002-04-16 Greentech, Inc. Compositions and methods for controlling pests using synergistic cocktails of plant alkaloids
KR100345226B1 (ko) 2001-08-29 2002-07-25 주식회사 태평양 천련자 추출물을 함유하는 미백용 화장료 조성물
US6866856B2 (en) 2002-12-31 2005-03-15 Avon Products, Inc. Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis
KR100750879B1 (ko) 2005-07-22 2007-08-22 건국대학교 산학협력단 고련피 추출물 및 이를 포함하는 알레르기 질환의 예방 및치료를 위한 약학조성물

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
"Remington' s Pharmaceutical Sciences,19th ed.,", 1995, MACK PUBLISHING COMPANY
CAPPARI ET AL., NEUROCHEM RES, vol. 33, 2008, pages 526 - 532
CARLSSON, J ALZ DIS, vol. 15, 2008, pages 327 - 338
IQBAL ET AL., ACTA NEUROPATHOL, 2009
REMINGTON: "Remington's Pharmaceutical Science, 15th Edition,", 1975
See also references of EP2444091A4
SHI; TANG, CHIN J NEUROSCI, vol. 20, 2004, pages 461 - 465
SMALL; DUFF, NEURON, vol. 5, 2008, pages 591 - 598
TANG ET AL., NEUROSCI RES, vol. 45, 2003, pages 225 - 231
WANG; YEN, J TRADIT CHIN MED, vol. 262, 1959, pages 46 - 49
YEON ET AL., PEPTIDES, vol. 28, 2007, pages 838 - 844
ZHANG ET AL., ACTA NORTHWE UNI AGRICULT SIN, vol. 21, 1993, pages 1 - 5

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115177745A (zh) * 2022-08-11 2022-10-14 福建医科大学附属口腔医院 一种川楝素及其纳米材料复合物的制备方法和应用

Also Published As

Publication number Publication date
KR101226660B1 (ko) 2013-01-25
KR20100136713A (ko) 2010-12-29
EP2444091A4 (en) 2013-02-20
WO2010147434A3 (ko) 2011-08-25
CN102458414A (zh) 2012-05-16
JP2012530698A (ja) 2012-12-06
EP2444091B1 (en) 2014-05-21
EP2444091A2 (en) 2012-04-25
JP5650731B2 (ja) 2015-01-07
CN102458414B (zh) 2014-01-08
ES2483736T3 (es) 2014-08-07

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