WO2010059920A2 - Système et procédé pour générer une image en 2d à partir d'un ensemble de données de tomosynthèse - Google Patents

Système et procédé pour générer une image en 2d à partir d'un ensemble de données de tomosynthèse Download PDF

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WO2010059920A2
WO2010059920A2 PCT/US2009/065288 US2009065288W WO2010059920A2 WO 2010059920 A2 WO2010059920 A2 WO 2010059920A2 US 2009065288 W US2009065288 W US 2009065288W WO 2010059920 A2 WO2010059920 A2 WO 2010059920A2
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Prior art keywords
images
image
tomosynthesis
mammogram
reconstruction
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PCT/US2009/065288
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English (en)
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WO2010059920A3 (fr
Inventor
Chris Ruth
Andrew Smith
Jay Stein
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Hologic, Inc.
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Application filed by Hologic, Inc. filed Critical Hologic, Inc.
Priority to EP09796173A priority Critical patent/EP2215600A2/fr
Priority to CN200980101409.XA priority patent/CN102763137B/zh
Priority to EP18207785.9A priority patent/EP3471064A1/fr
Priority to CA2702782A priority patent/CA2702782C/fr
Priority to JP2011537644A priority patent/JP5501370B2/ja
Publication of WO2010059920A2 publication Critical patent/WO2010059920A2/fr
Publication of WO2010059920A3 publication Critical patent/WO2010059920A3/fr

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    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T11/00—2D [Two Dimensional] image generation
    • G06T11/003—Reconstruction from projections, e.g. tomography
    • G06T11/006—Inverse problem, transformation from projection-space into object-space, e.g. transform methods, back-projection, algebraic methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/025—Tomosynthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/50—Clinical applications
    • A61B6/502—Clinical applications involving diagnosis of breast, i.e. mammography
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T15/00—3D [Three Dimensional] image rendering
    • G06T15/08—Volume rendering
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10081—Computed x-ray tomography [CT]
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10116—X-ray image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20212—Image combination
    • G06T2207/20221—Image fusion; Image merging
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30068—Mammography; Breast
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2210/00—Indexing scheme for image generation or computer graphics
    • G06T2210/41—Medical
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2211/00—Image generation
    • G06T2211/40—Computed tomography
    • G06T2211/421—Filtered back projection [FBP]
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2211/00—Image generation
    • G06T2211/40—Computed tomography
    • G06T2211/424—Iterative

Definitions

  • This patent specification pertains to x-ray mammography and tomosynthesis, and more specifically to techniques and equipment for acquiring and/or synthesizing, processing, storing and displaying mammograms, tomosynthesis projection images, synthesized two-dimensional (2D) images and tomosynthesis reconstructed images, and to medical image softcopy reading systems, to hanging protocols and to other medical image display features.
  • Mammography has long been used to screen for breast cancer and other abnormalities and for diagnostics.
  • mammograms were formed on X-ray film, but more recently flat panel digital imagers have been introduced that acquire a mammogram in digital form and thereby facilitate analysis and storage and provide other benefits as well.
  • X-ray tomosynthesis of the breast has been proposed recentiy, as discussed in the earlier-filed applications identified above, and clinical testing has been carried out.
  • the assignee of this patent specification, Hotogic, Inc. has demonstrated at trade shows in this country a fused, multimode mammography/tomosynthesis system that takes either or both types of images, either while the breast remains immobilized or in different compressions of the breast.
  • Tomosynthesis as used in the systems and methods disclosed in this patent specification typically involves acquiring a plurality of tomosynthesis projection images Tp at respective angles relative to the breast, and reconstructing there from a plurality of tomosynthesis reconstructed images Tr representative of breast slices that have selective thicknesses.
  • a synthesized 2D image is generated using at least one of the tomosynthesis projection images TP and/or the tomosynthesis reconstructed images Tr.
  • the reconstructed images may be reconstructed using any one of a variety of techniques, including but not limited to filtered back projection in either spatial or frequency domain, maximum likelihood reconstruction, iterative reconstruction, reconstruction using algebraic methods, minimum likelihood or other known or developed three dimensional reconstruction methods.
  • The may be obtained using projection data obtained based on any coordinate system, including a Cartesian coordinate system, a cone beam coordinate system, where the cone beam coordinate system may be defined by geometric information of an associated tomosynthesis acquisition system or alternatively may be a virtualized cone beam coordinate system defined relative to a 'virtual' tomosynthesis acquisition system. Further, following reconstruction, the reconstructed data may projected onto any other different coordinate system; for exampie, reconstruction data obtained using a first coordinate system may be projected into a second, different coordinate system.
  • any coordinate system including a Cartesian coordinate system, a cone beam coordinate system, where the cone beam coordinate system may be defined by geometric information of an associated tomosynthesis acquisition system or alternatively may be a virtualized cone beam coordinate system defined relative to a 'virtual' tomosynthesis acquisition system.
  • the reconstructed data may projected onto any other different coordinate system; for exampie, reconstruction data obtained using a first coordinate system may be projected into a second, different coordinate system.
  • a cone beam reconstruction may be projected onto a virtual cone beam coordinate system or a Cartesian coordinate system, etc, in summary, projection images may be reconstructed onto any first coordinate system and then projected onto any second, different coordinate system.
  • the synthesized 2 D image is referred to herein as a synthesized mammogram (Ms) or other synthesized 2D tomosynthesis image (T2d).
  • Ms synthesized mammogram
  • T2d synthesized 2D tomosynthesis image
  • the synthesized 2D image may be generated using any combination of tomosynthesis projection data or reconstructed data generated using from, or projected onto, any coordinate system.
  • the synthesized 2D image of the present invention is advantageously displayed together with tomosynthesis image data (Tr and/or Tp images) at a review workstation.
  • tomosynthesis image data Tro and/or Tp images
  • a medical professional may utilize existing expertise gained from past review of mammogram data to more efficiently assess and view the 3D tomosynthesis data, without independent acquisition of a mammogram.
  • the synthesized 2D image Ms may be displayed together with an Mp image previously obtained for the patient, to enable comparison of ⁇ ke images using known methods before using the Tr data.
  • the method of synthesizing 2D images from Tp and/or Tr data may be used to compare mammograms obtained by a mammography-only machine against existing tomosynthesis data for a patient, thereby increasing the utility of tomosynthesis data by facilitating transport between systems of differing capabilities.
  • systems including mammo only systems, tomo only systems and combo systems, which may benefit from the ability to synthesize a 2D image from tomosynthesis data, either for comparison with mammography data, or increasing the efficiency of diagnostic workflow.
  • T images Proper display techniques make the presentation of Ms, Mp, Tp and/or Tr images (collectively referred to here as T images) more effective and efficient for review by health professionals.
  • T images When tomosynthesis projection images Tp are acquired, (with or without conventional 2D mammograms Mp) improved display methods facilitate the display of both T and Mp and/or Ms images.
  • Effective display approaches also are desirable when tomosynthesis images Tp and/or Tr that are acquired at one time need to be compared to mammograms Mp and/or to tomosynthesis images Tp and/or Tr acquired at a different time.
  • the present invention enables generation of a synthesized mammogram image Ms.
  • Effective displays also are desirable when oniy Tr and/or Tp images are being displayed.
  • An Ms image may be provided in any number of ways using one or more Tp images and/or one or more Tr images. A variety of techniques for generating Ms images will be described in more detail below.
  • the Ms image may be dynamically generated prior to display, or alternatively may be pre-generated and stored.
  • Ms images may be dynamically synthesized prior to display of Tr /Tp images, may be generated upon acquisition of the Tp images and stored with Tp images, or may be generated following reconstruction of the Tr images, using a combination of Tp and Tr images.
  • the display may be adapted to provide concurrent, toggled, overlaid or cine display of any combination of one or more of the Ms, Mp, Tp and Tr images.
  • Concurrent display may be in the form of a side by side view, either on the same display or on neighboring displays, or alternatively may be in the form of a thumbnail scout view of one image provided within another image.
  • the present invention supports reflective marking of the different images; for example should the technician mark an area of interest on the mammogram (or tomo slice) or move a marker on the mammogram, the mark and/or movement of the mark is reflected in the appropriate location of the tomo slice (or mammogram).
  • CAD Computer Aided Detection
  • FIG. 1 is a block diagram illustrating flow of data through a system which includes a combination mammography/tomosynthesis acquisition station or a tomosynthesis only acquisition station and where reconstruction of tomosynthesis slice images Tr and synthesis of the Ms images occurs after storage of acquired tomosynthesis projection images Tp.
  • FIG. 2 is a block diagram illustrating flow of data through a system which includes a combination mammography/tomosynthesis acquisition station or a tomosynthesis only acquisition station and where the reconstruction of images
  • FIC. 3 is a block diagram illustrating flow of data through a system which includes a mammography-only acquisition system, and where reconstruction of tomosynthesis slice images Tr and/or synthesis of the Ms images occurs after storage of acquired tomosynthesis projection images Tp.
  • FIG. 3 illustrates an example where four units acquiring Tp images feed a single unit that reconstructs Tr images.
  • FIG. 4 illustrates a concurrent display of an Ms image and a Tr in substantially same area on a screen, with an example of a non-numeric indication of a thickness and position in the breast of a breast slice represented by a Tr image.
  • FiG FiG.
  • FIG. 5 illustrates a concurrent display of Ms and Mp images, at separate areas on a screen or as combined images.
  • FIG. 6A illustrates a display of a Tr image, with an integrated window including a scout view of a 2D synthesized image, for use in guiding a medical professional's evaluation of the Tr data.
  • FIG. 6B illustrates a display of a Tr image with an integrated window that includes both an Ms image and a legacy Mp image, shown as scout views, for use in guiding a medical professional's evaluation and workflow using the Tr image data.
  • FIG. 6A illustrates a display of a Tr image, with an integrated window including a scout view of a 2D synthesized image, for use in guiding a medical professional's evaluation of the Tr data.
  • FIG. 6B illustrates a display of a Tr image with an integrated window that includes both an Ms image and a legacy Mp image, shown as scout views, for use in guiding a
  • FIG. 7 illustrates a display of Ms/Mp/Tr/Tp images with CAD marks and a non-numeric indication of Tr images in which CAD marks exist;
  • FIG. 8 illustrates a display of an MS image together with a Tr/TP image, wherein a region of interest marker placed in a first image is reflected into a second image;
  • FIG. 9 is a block diagram illustrating exemplary components of an x-ray acquisition and display system that incorporates the 2D synthesis method of the present invention.
  • FiG. 1 0 illustrates image planes of a mammogram and tomosynthesis slice images
  • Figs. 1 I a- l i e illustrate, respectively, tomosynthesis reconstruction into a Cartesian geometry, into a cone-beam geometry and into a virtual geometry;
  • FIG. 12 is a flow diagram provided to illustrate exemplary steps that may be performed in a 2D image synthesis process which uses tomosynthesis data.
  • the notation Mp refers to a conventional mammogram, which is a two-dimensional projection image of a breast and encompasses both a digital image as acquired by a flat panel detector or another imaging device and the image after conventional processing to prepare it for display to a health professional or for storage, e.g. in the PACS system of a hospital or another institution.
  • Mp cumn t refers to a mammogram that is acquired by an acquisition system for patient diagnosis
  • Mp ⁇ eg acy refers to a mammogram image of a patient that had been taken on a previous review of the patient, for example one that is to be used for comparison against an Mp CU rrent to identify changes in a patient's breast structure.
  • Tp refers to an image that is similarly two-dimensional but is taken at a respective tomosynthesis angle between the breast and the origin of the imaging X-rays (typically the focal spot of an X-ray tube), and also encompasses the image as acquired as well as the image after being processed for display or for some other use.
  • Tr refers to an image that is reconstructed from images Tp, for example in the manner described in said eariier-filed patent applications, and represents a slice of the breast as it would appear in a projection X-ray image of that slice at any desired angle, not only at an angle used for Tp or Mp images.
  • Ms refers to synthesized 2D projection images which simulate mammography images, such as a craniocaudal (CC)_ or mediolateral oblique (MLO) images, and are constructed using tomosynthesis projection images Tp, tomosynthesis reconstructed images Tr or a combination thereof.
  • Ms images may be provided for display to a health professional or for storage in the PACS system of a hospital or another institution.
  • Tp, Tr, Ms and Mp also encompasses information, in whatever form, that is sufficient to describe such an image for display, further processing, or storage.
  • the images Mp, Ms. Tp and Tr typically are in digital form before being displayed, and are defined by information identifying properties of each pixel in a two-dimensional array of pixels.
  • the pixel values typically relate to respective measured or estimated or computed responses to X-rays of corresponding volumes in the breast (voxels or columns of tissue).
  • the geometry of the tomosynthesis images (Tr and Tp) and mammography images (Ms, Mp) are matched to a common coordinate system as described in U.S. Patent application serial number 1 1 /667,650 "Matching Geometry Generation and Display of Mammograms and Tomosynthesis Images", filed November 1 5, 2005.
  • FiC, 1 illustrates flow of data in one example of an image generation and display system disclosed in this patent specification.
  • An image data acquisition system 1 acquires tomosynthesis image data for Tp images of patients' breasts, and can take the form of and use the acquisition methods of any of the systems disclosed in said earlier-filed patent applications. If the system is a combo system, Mp images may also be generated (as indicated by dashed line and label Mpcurre ⁇ t in Figure 1 ).
  • Some dedicated tomosynthesis systems or combo systems may be adapted to accept and store legacy mammogram images (indicated via dashed line and legend Mpiegacv i n Figure 1 ) in a Picture Archiving and Communication System (PACS) storage device 2, although it is not a requirement that any Mp images be acquired or pre-stored.
  • PACS Picture Archiving and Communication System
  • the data describing projection images Tp are sent to storage device 2, which is preferably a DICOM-compliant PACS.
  • the data Tp images are sent, from either acquisition system 1 or from storage device 2, to a computer system 3 configured as a reconstruction engine that can perform tomosynthesis reconstruction into images Tr representing breast slices of selected thickness and at selected orientations, as disclosed in said earlier-filed patent applications and detailed below.
  • the computer system may be further configured with 2D synthesis functionality 4, which may operate substantially in parallel with reconstruction engine 3 to generate a synthesized 2D image (interchangeably referenced as T2d or Ms).
  • T2d synthesized 2D image
  • the reconstructed slice images Tr are then sent to a display system 5 so that they can be viewed. If the reconstruction engine 3 is connected to display 5 via a fast link, then large datasets can be transmitted quickly.
  • Other images, such as the Ms 1 Mp and/or Tp images may also be forwarded to the display unit for concurrent or toggled viewing.
  • a patient may have compiled a history of mammogram images associated with past screenings. Such a patient may be examined at a facility with updated equipment, for example one that includes a dedicated tomosynthesis system.
  • a facility with updated equipment for example one that includes a dedicated tomosynthesis system.
  • To compare historical information against existing diagnostic images it may be desirable to store such legacy Mp images, generate Ms images from a tomosynthesis acquisition of the dedicated tomo system and compare like- formatted representations.
  • FIG. 2 an alternative design of an image acquisition and display system of the present invention is illustrated in FIG. 2,
  • the reconstruction unit 3 and 2D synthesizer 4 are directly coupled to the acquisition station 1 , and it is the reconstruction images Tr and synthesized images Ms that are sent to storage system 2 for subsequent display on display devices 5, which may also store legacy Mp images.
  • the reconstruction unit 3 and 2D synthesizer 4 are directly coupled to the acquisition station 1 , and it is the reconstruction images Tr and synthesized images Ms that are sent to storage system 2 for subsequent display on display devices 5, which may also store legacy Mp images.
  • Tr and Ms images reconstructed or synthesized from Tp image data taken after the upgrade will automatically reflect this new algorithm
  • Tr and Ms images reconstructed or synthesized from Tp image data taken prior to the upgrade will have been reconstructed with the older version and properly stored as such.
  • the images stored on a PACS wili be the same as they were viewed by the radiologist or other health professional during the detection/diagnosis or other earlier review.
  • Another advantage of the system of FIG. 2 is the reduced system reconstruction burden compared to the system in FIG. 1 , where the reconstruction engine is just prior to the display. Sf there are multiple acquisition systems, for example four systems that are all pushing images to the display, then the reconstruction engine will need to reconstruct images at 4 times the rate of a reconstruction engine in a system having only one acquisition system, for the same total patient throughput.
  • FIG. 3 illustrates another image acquisition and display system which may benefit from the 2D image synthesizing process of the present invention
  • the image acquisition device 1 1 is a mammography only device.
  • One advantage of digital imaging is the portability of data; it is conceivable that patients that switch between different imaging locations may be exposed to imaging equipment with different capabilities. For example, a patient may undergo an exam at an imaging center that includes a tomosynthesis only system, and subsequently undergo an exam at a location that includes a mammography only acquisition system, (or visa versa).
  • tn FIC is another image acquisition and display system which may benefit from the 2D image synthesizing process of the present invention
  • storage device 2 is adapted to store both legacy Mp (if any) as well as legacy Tp images.
  • the system may include reconstruction unit 3.
  • Other systems which have only the capability of viewing mammograms may not include this unit, and thus the unit and tomosynthesis data are all shown in dashed lines in Figure 3.
  • Tp and/or Tr data are retrieved from the storage device and forwarded to the 2D synthesizer 4.
  • the resulting Ms image is displayed together with the current Mp on display 5.
  • the 2D synthesizing software may be provided as a downloadable application that facilitates viewing of tomosynthesis data on existing mammography systems.
  • the question of which system design will place a greater burden on the PACS storage of an institution will depend upon the sizes of the raw projections Tp and of the reconstructed images Tr. In general, if the raw projections Tp are smaller than the reconstructed images Tr, it might be desirable to save in PACS the raw or preliminarily processed data for Tp images and reconstruct the final Tr images on demand for display or other use. In ali cases it may be desirable to keep both of these sizes as small as possible.
  • One way to reduce the size of an original dataset for a Tp image is to bin the projection Tp data to as large a pixel size as practical without reducing clinical efficacy of the final Ms, Tp or Tr images.
  • the images can be formatted consistent with DICOM standards.
  • each raw or displayed projection image set, synthesized image or reconstructed slice image set for a single view is stored as a single Secondary Capture image instance according to DICOM.
  • the image pixel data can be encoded in a selected compressed format (CODEC) that includes ai! projection or slice images.
  • CDEC compressed format
  • the imaging and display system of the present invention includes a 2D synthesizer for generating 2D images simulating mammograms taken at both a CC and MLO orientation using a combination of one or more Tp and/or Tr images.
  • a display of the system preferably should be able to display Ms, Mp and Tr (and/or Tp) images concurrently (either in separate windows on the display, on separate monitors of a technology workstation, or overlaid) or sequentially or in toggled mode, wherein the Ms, Mp, Tp and Tr images may be those currently acquired, or those that were acquired in previous studies.
  • the display can simultaneously or sequentially or in toggled mode display mammograms (Ms, Mp) and tomosynthesis images Tr (and/or Tp) from the current and previous studies.
  • Tr slices can be reconstructed all to the same size, which can be the same as the size of an Mp or Ms image of the breast, or they can be initially reconstructed to sizes determined by the fan shape of the x-ray beam used in the acquisition and later converted to that same size by appropriate interpolate]on/extrapolation.
  • Images of different types and from different sources can be displayed in desirable size and resolution.
  • an image can be displayed in (1 ) Fit To View Port mode, in which the size of the displayed image size is maximized such that the entire imaged breast tissue is visible, (2) True Size mode, in which a display pixel on the screen corresponds to a pixel of the image, or (3) Right Size mode, in which the size of a displayed image is adjusted so that it matches that of another image that is concurrently displayed or with which the displayed image is or can be toggled.
  • Selected hanging protocols are provided that are unique to the different types of images with which the disclosed system deals.
  • the hanging protocols for 2D images e.g. Ms or Mp images
  • 3D images e.g. Tr images
  • the hanging protocols for 2D images are linked so that when one type of image is displayed for a given breast the other type is displayed as well.
  • Ms/Mp image of a breast is displayed
  • a tile of the Tr images and/or of the Tp images is automatically displayed at the same time, with a desired hanging protocol that may involve scrolling or cine mode presentation, or may require user input so select a particular subset of the Tr and/or Tp images or a particular individual Tr/Tp image.
  • a combined hanging protocol set can be provided for 2D and 3D images that are concurrently displayed (either on a common display on adjacent displays, or overlaid) or toggled such that only one type is displayed at one time.
  • the combined hanging protocol can include provisions for linked display of CAD information associated with one or both of the 2D and 3D images involved in the hanging protocol.
  • the hanging protocols for 2D images are made different from those for 3D images. Methods of identifying which image corresponds to which image type in displays of Ms, Mp, Tr and/or Tp images are desirable. One example of such a method is illustrated in FIC. 4. An icon is used to identify an image type.
  • the symbol MS on the left image 300 indicates that it is a synthesized mammogram.
  • the symbol T on the right image 310 indicates that it is a tomosynthesis slice image Tr.
  • a symbol Tp (not shown) can be used to indicate that the displayed image is a tomosynthesis projection image Tp
  • a symbol 2D may be used to indicate that it is a 2D image
  • the symbol 3D (also not shown) can be used to indicate that an image on the display is a 3D image.
  • Other symbols/icons serving a similar purpose can be used instead of, or in addition, to those identified above.
  • the images can be displayed without an identification of the type of image.
  • a Tr image and an Mp or Ms image can be displayed at the same time or toggled without displaying an indication of the type of the image that is visible. This may be desirable in cases such as when a user has a familiar hanging protocol and does not need an express identification of the type of image.
  • the system described as a non-limiting example in this patent specification is capable of receiving and displaying selectively the tomosynthesis projection images Tp, the tomosynthesis reconstruction images Tr, the synthesized mammogram image Ms and/or the mammogram images Mp, or a single type, or any sub combination of types. It can receive images stored uncompressed, losslessly compressed, and lossyly compressed. It can also include algorithms to decompress images sent in compressed format.
  • the system has software to perform reconstruction of tomosynthesis image data for images Tp into images Tr and software for synthesizing mammogram images Ms. Further, it can include software to generate 3D display images from the tomosynthesis reconstructed images Tr using standard known methods such as MIP (Maximum Intensity Projection), summing, and/or weighted summing algorithms.
  • Figure 5 illustrates an exemplary display of an Mp image together with a 2D synthesized image; each image may be labeled to indicate whether the image is from a current acquisition, or based on legacy data.
  • the Mp image may be a stored legacy mammogram, and the 2D Ms image may be generated from a current tomosynthesis acquisition and may be provided as an initial view to guide the medical professional's perusal of the tomosynthesis data.
  • the Mp image may be based on a current acquisition, for example via a combo mammo/tomo system or by a tnammography-only system, and the Ms image may be generated from previously stored tomosynthesis data, such as described in Figure 3, thereby allowing for comparison of like images to more easily identify regions of interest.
  • Figure 6A illustrates the display of the synthesized 2D image as a scout view thumbnail image which may be provided as an overlay in a display of Tp and/or Tr images. Such a scout view may be used to guide the workflow of the medical professional during review of the tomosynthesis images.
  • Figure 6B illustrates two scout views, showing, for example, a legacy 2D image together with a current 2D image. The ability to compare the two images may further assist the medical workflow.
  • Figure 6B illustrates a legacy Mp image together with an Ms image, any two 2D images associated with differently timed acquisitions could be used, and the present invention is not limited that the particular images shown in the figures.
  • Figure 7 illustrates a display of two synthesized 2D images, of different views (CC and MLO).
  • a Computer Assisted Detection (CAD) process has been applied to either the synthesized 2D views or alternatively to the reconstructed tomosynthesis data, providing resulting CAD marks 350.
  • the CAD marks resulting from processing a mammogram may be projected onto the 3D tomosynthesis image and visa versa.
  • the present invention further envisions that the CAD marks may be similarly translated across images when using 2D synthesized images.
  • a variety of methods can be used to select the particular image to be displayed.
  • a menu driven interface may be automatically populated with the types of images that are available for display, including both currently acquired images and a selection of available legacy images.
  • Software allows the selection of one or more image planes, for use in image processing, or to change window/level or to change slice height, etc.
  • the menu driven interface may be further populated with display arrangements, including overlaid, cine, inset views, etc.
  • Alternative methods, such as drag and drop techniques can be used to position images on the screen. These sets of images can be on one monitor, or on multiple monitors or other displays.
  • the display can map the images so the pixel spacings are identical.
  • This pixel spacing adjustment can also be used for Ms, Mp and Tr/Tp images.
  • the Ms, Mp and Tr/Tp images are displayed at the same pixel size.
  • Zooming can be done on any of the images on the display.
  • the zoomed area will zoom both the Ms/Mp and the Tr slice images as they are toggled, in other words, no matter what image type is displayed, it will be zoomed.
  • Window/level can be independently, or jointly, applied to any combination of images on the display, in particular, for the Tr images the window/level can be applied to just the single displayed Tr slice image, or all the Tr slice images, if there is a magnified region of an image, window/level can be selectively applied just to the magnified region or to the entire image.
  • the synthesized mammogram may be used in conjunction with a tomosynthesis image at the technologist workstation to assist in the identification of tomosynthesis slices associated with regions of interest.
  • a technologist or other user may place a marker (41 OA) or otherwise highlight regions of interest (420A 1 430A) on a mammogram.
  • the present invention automaticaily reflects the marker, by generating a duplicate marker at a corresponding x-y location on the tomographic image 400B as markers 41 OB, 420B, and 430B.
  • the reflected mark moves similarly in the alternate image.
  • the automatic reflection of the marker can easily be accomplished using standard graphic imaging techniques because the coordinate systems of the two images have already been aligned for display purposes; thus there will be a one to one relationship between the x-y location of the added mark, and the x-y location on the alternate image where the mark should be reflected.
  • the makers essentially lie on a two-dimensional plane which lies over the respective images, and remain in position as the user scrolls depthwise through the tomographic slice images. Thus the marker will remain over the tomosynthesis s ⁇ ces as the user scroll depth-wise through the tomosynthesis slices.
  • FIG. 9 illustrates an overall mammography/tomography system in which the preferred but non-limiting examples discussed above can be implemented.
  • the Figure illustrates in block diagram form an x-ray data acquisition unit 100 that includes an x-ray source 1 1 0 imaging a breast 1 1 2.
  • An x-ray imager 1 16 such as a fiat panel x-ray imager commercially available from the assignee of this patent specification generates projection image data that can be a mammogram Mp or a tomosynthesis projection image Tp.
  • X-ray source 1 10 is mounted for movement so that images Tp can be taken at different angles.
  • X-ray imager 1 16 can be stationary or it can also move, preferably in synchronism with movement of x-ray source 1 1 0.
  • Elements 1 1 0 and 1 1 6 communicate with x-ray data acquisition control 1 18 that controls operations in a manner known from said earlier-filed patent specifications.
  • X-ray image data from imager 1 1 6 is delivered to processing unit 1 20.
  • Processing unit 120 comprises reconstruction software 1 22, which may be stored in a computer readable medium of unit 12.
  • the reconstruction software processes x-ray image data as known from said earlier-filed patent application into Tp and Tr image data, which may be stored in storage device 1 30 and displayed at image display unit 1 50 as disclosed in the various embodiments described above.
  • tomosynthesis reconstruction may use any of the methods described in the "Matching Geometry" patent apptication (seria! number 1 1 /667,650) referenced above.
  • the disclosed process and system generate and display tomosynthesis slice images of a patient's breast such that an object in the breast is at same or at least matching relative places in each slice image in which it is visible and, preferably, also at the same or at least matching place as in a conventional mammogram of the same breast.
  • the method and system described in the "Matching Geometry" patent application obtain 2D x-ray projection data for tomosynthesis images preferably using a cone-shaped or pyramid-shaped imaging x-ray beam, and generate tomosynthesis images such that they conform to the same geometric coordinate system as a mammogram and, preferably, to the same coordinate system as a 2D projection mammogram.
  • anatomical structures appear at geometrically matching or corresponding places in such tomosynthesis images and, preferably, in the mammogram.
  • the tomosynthesis images can be generated in a two-step computer-implemented process that first reconstructs tomosynthesis images in an initial coordinate system, such as a Cartesian coordinate system, in which objects are not or may not be at matching positions in different tomosynthesis images or in the mammogram, and then projects those images into another coordinate system, such as the coordinate system of the mammogram.
  • the reconstruction can directly generate tomosynthesis images in a desired coordinate system, e.g., the cone beam geometry of the mammogram.
  • this direct reconstruction can further be projected onto a different coordinate system if desired, for example to modify the plane of reconstruction. For example, FIC.
  • FIG. 10 illustrates a front view where the long axis of the compressed breast 10 is normal to the sheet.
  • the breast 10 is compressed between an image receptor 1 2, such as a flat panel digital imager, and a compression paddle 14, and is imaged with a cone-shaped or pyramid-shaped x-ray beam 16 from an x-ray source 18.
  • An image receptor 1 2 such as a flat panel digital imager
  • a compression paddle 14 is imaged with a cone-shaped or pyramid-shaped x-ray beam 16 from an x-ray source 18.
  • Two objects are illustrated in breast 1 0, object #1 at slice A and object #2 at slice B.
  • object is used here to refer to any structure that can be imaged in a mammogram or a tomosynthesis image, such as a lesion in the breast
  • the term slice is used to refer to a layer of the breast of a finite thickness, e.g. thickness in the z-direction, that is less than the total breast thickness.
  • a slice can be a few mm thick, or thinner or thicker. Because the objects #1 and #2 are along the same x-ray trajectory 20, they appear superimposed in a mammogram. However, because x-ray trajectory 20 is not normal to the image plane of receptor 1 2, as is the general case with x-ray trajectories when using such cone-beam geometry, the two objects appear at different xy locations in tomosynthesis projection images for slice A and siice B.
  • the "Matching Geometries" application describes a reconstruction and display method for tomosynthesis images that matches the coordinates of tomosynthesis images with mammograms.
  • All relevant x-ray measurements can be obtained as respective 2D sets of pixel values (x-ray measurements for elemental picture areas) at each of several different angles of an x-ray beam relative to a breast, e.g. at several equidistant angles over a range.
  • Other raw x-ray data acquisition techniques can be used in the alternative.
  • those pixel values can be reconstructed into a rectangular Cartesian coordinate system (30 in FtG. 1 I a) using known reconstruction algorithms such as filtered back projection, iterative reconstruction, maximum likelihood reconstruction, or others. As illustrated in FlG.
  • the voxels (elemental volume elements) that are imaged as respective pixels in the tomosynthesis slice images are aligned along tines normal to the image plane of receptor 1 2.
  • the result can be conceptualized as a set of pixel values representing x-ray properties of the voxels that are in the 3D space bound by the image plane of receptor 1 2 at the bottom, compression paddle 1 4 on top, and on the sides by the boundaries of an x-ray beam 16 that impinges on receptor 1 2, and are uniformly spaced in xy planes. Because the x-ray beam 16 is cone-shaped, the sides of this 3D space slope at least on three sides of the beam, and the x-ray trajectories from source 1 8 to receptor 12 diverge in the general case.
  • each x-ray trajectory such as trajectory 20 is non-normal to the image plane of receptor 12.
  • Tomosynthesis image slices that match the geometry of the mammogram can be obtained by projecting each of several horizontal breast slices separately onto the image plane of the mammography images, taken along the actual x-ray trajectories included in x-ray beam, using a computer-implemented process adapted without undue experimentation to a particular -xray data acquisition geometry by a programmer of ordinary skill in the art.
  • the reconstruction geometry can be a cone beam coordinate system 31 shown in FIG.
  • a geometry matrix can be defined from a geometry calibration file and input projection angles appropriate to the acquisition system 1 1 for use in backprojection, from fits to the matrix elements determined from a geometry calibration of the acquisition system 1 1 and input projection angt :es measured by an encoder in the acquisition system 1 1 .
  • Image processing and filtering can be carried out on the images prior to reconstruction, using image processing techniques known in technologies such as CT scanning and tomosynthesis. A known skin line correction can also be applied at this stage. A backprojection can then be carried out, one tomosynthesis slice at a time, using the geometry matrix as follows: [0061 ] Equation I:
  • u,v,z is the location of the reconstructed pixel
  • Mi is the 3x4 geometry matrix for projection I
  • (x,y,z) is the location of an image pixel
  • (dx, dy) is the location on the x-ray detector element or area for the line that connects a focal spot in source 1 8 and the image pixel.
  • Figure 1 I c illustrates exemplary virtual cone beam geometry, where the cone beam coordinate system is derived from a hypothetical acquisition system having virtual focal spot positioning.
  • Such a coordinate system like that of Figure 1 I b, has different pixel spacing for each tomosynthesis slice. However, in such an arrangement the angle of pixel spacing close to the chest wail is increased.
  • Other virtual coordinate systems, associated with different hypothetical acquisition system or which focus on different portions of the imaging area may be substituted readily herein within the scope of the present invention.
  • the tomosynthesis image slices to be reconstructed can be parallel to a
  • a preferred orientation can be an orientation in which a particular mammogram is taken.
  • the use of the perspective matrix allows the reconstructed image to be viewed at any orientation.
  • reconstructing tomosynthesis slice images can involve: 1 .) The selection of the orientation of image slices to be reconstructed.
  • the slice can be either parallel to the "default" reference plane as suggested by Equation i, or at another more preferred orientation, which is defined by a 4x4 matrix multiplication operation to the original 3x4 matrix M, as expressed by Equation II; and 2.) Selection of the reconstruction voxel grid in space, which can be either a Cartesian grid (FIG. 1 1 a) or a Cone beam grid (FIG. 1 1 b) or virtual grid (FIG. l i e).
  • Processing unit 120 further includes 2D synthesis software which uses one or more of the Tp and/or Tr images to synthesize a 2D image.
  • 2D synthesis software which uses one or more of the Tp and/or Tr images to synthesize a 2D image.
  • Tp images may be used individually, or aiternatively a subset of Tp images or a subset of Tr slices (reconstructed using any of the methods above) may be combined, using algebraic methods (averaging, weighted averaging, statistics or other methods), maximum intensity projection, or other known means to provide the 2D image.
  • a tomo data set consists of TpO raw projections, Tp processed projections, and Tr reconstructed slices.
  • the Tp processed projections have been processed as described in the '650 application to perform at least one of coordinate geometry matching and data set size reduction.
  • a single 'synthesized' 2D image T2d is built from the 3D tomo data set alone.
  • the 2D synthesized image may provide a quick overview of the breast anatomy to facilitate diagnosis and help the radiologist focus on specific regions when analyzing the 3D slices.
  • the image T2d may replace the Mp image that would normally be present in a combo mode procedure, or may be viewed against legacy Mp images, or displayed in a variety of other combinations.
  • FIG. 1 2 is a flow diagram that illustrates exemplary steps that may be performed in a 2D synthesis process.
  • Figure 9 assumes that methods described in the '650 application have been used to generate a set of slices Tr as in put to the process, wherein the set of slices are represented in a Cone Beam or Cartesian coordinate system, or alternatively represented in a virtual coordinate system (associated with a virtual acquisition system). It should be understood that although the below equations describe a method using Tr images, similar processing may be performed with any subset of the Tp images.
  • the Tr data set is apportioned into a slabbed set of slices Tslab. That is a number of images Tr are effectively combined, using maximum intensity projection (MIP) or averaging to generate a set of Tslab slices. Equation III below illustrates how the set Tslab is formed using MIP, while Equation !V below illustrates how the set Tslab may be formed using averaging.
  • MIP maximum intensity projection
  • TslabO.z] MAX(Tr[j,z-Nslab/2I, Trjj,z-Nslab/2+l ,...,Tr[j,z+Nsiab/2])
  • Tslab[j,zl AVE(TrU ,z-Nslab/2], Tr[j,z-Ns1ab/2 + l ,...,Tr[j,z+Nslab/2])
  • the set of slices is re-projected to produce an initial image T2dO.
  • Re-projection methods are well known in the field of image processing. A source point and image plane is chosen, on opposite sides of the image volume. Pixels are obtained by projecting the source point through the slice set to an image plane point. The pixel value is summed at each slice location by interpolating values in the original slices. Note, in the case of cone beam coordinate system reconstruction as described in the '650 application and above, the re-projection is just a sum of pixel values, with no interpolation involved, and is represented by Equation V below:
  • zmin may be chosen to exclude slices near the breast boundary, or skirt. This may reduce artifacts.
  • N zmax-zmin+ l .
  • Step 930 performs an optional step of filtering the re-projected image to produce T2d.
  • the filtering that is performed should be generally in the direction of the source motion in the original tomosynthesis image acquisition. Although not required, filtering may help reduce additional blur produced in the re- projection due to artifacts in the s ⁇ ces Tr. It is further noted that the filtering step 930 may be performed prior to the re-projection of step 920, but at a computational cost.

Abstract

L'invention porte sur une image de mammogramme en 2D qui est synthétisée à partir d'au moins l'une parmi des images de projection de tomosynthèse et/ou des données d'image reconstruites par tomosynthèse. Sous une forme la plus simple, le mammogramme peut être synthétisé par la sélection de l'une des images de projection de tomosynthèse pour un affichage en tant que mammogramme synthétisé. D'autres procédés de synthèse d'un mammogramme comprennent la reprojection et le filtrage de données de projection et/ou de données reconstruites. Le mammogramme synthétisé est avantageusement affiché conjointement avec au moins une partie des données reconstruites pour aider l'examen des données reconstruites. La présente invention fournit ainsi une image familière qui peut être utilisée pour faciliter l'examen d'un ensemble de données de tomosynthèse.
PCT/US2009/065288 2008-11-21 2009-11-20 Système et procédé pour générer une image en 2d à partir d'un ensemble de données de tomosynthèse WO2010059920A2 (fr)

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EP09796173A EP2215600A2 (fr) 2008-11-21 2009-11-20 Système et procédé pour générer une image en 2d à partir d'un ensemble de données de tomosynthèse
CN200980101409.XA CN102763137B (zh) 2008-11-21 2009-11-20 用于由层析数据集生成2d图像的系统和方法
EP18207785.9A EP3471064A1 (fr) 2008-11-21 2009-11-20 Système et procédé pour générer un mammogramme synthétisé à partir d'un sous-ensemble d'images de projection de tomosynthèse
CA2702782A CA2702782C (fr) 2008-11-21 2009-11-20 Systeme et procede pour genere une image 20 a partir d'un ensemble de donnees de tomosynthese
JP2011537644A JP5501370B2 (ja) 2008-11-21 2009-11-20 トモシンセシスデータセットから２ｄ画像を生成するためのシステムおよび方法

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