WO2009157877A1 - A sorbent for a dialysis device - Google Patents

A sorbent for a dialysis device Download PDF

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Publication number
WO2009157877A1
WO2009157877A1 PCT/SG2009/000229 SG2009000229W WO2009157877A1 WO 2009157877 A1 WO2009157877 A1 WO 2009157877A1 SG 2009000229 W SG2009000229 W SG 2009000229W WO 2009157877 A1 WO2009157877 A1 WO 2009157877A1
Authority
WO
WIPO (PCT)
Prior art keywords
particles
sorbent
layer
microns
cation exchange
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SG2009/000229
Other languages
English (en)
French (fr)
Inventor
Kim Cheng Tan
Christian Gert Bluchel
Lay Leng Chew
Kee Kiat Chua
Lai Ching Helen Ho
Keng Hong Lee
Liutong Lin
Weng Cheong Roy Tang
Keng Mun Yue
Yanmei Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temasek Polytechnic
Original Assignee
Temasek Polytechnic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41444786&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009157877(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP09770498.5A priority Critical patent/EP2303354B1/en
Application filed by Temasek Polytechnic filed Critical Temasek Polytechnic
Priority to JP2011516227A priority patent/JP2011525403A/ja
Priority to CN2009801323271A priority patent/CN102123749A/zh
Priority to AU2009263045A priority patent/AU2009263045B2/en
Priority to NZ590467A priority patent/NZ590467A/xx
Priority to BRPI0915397A priority patent/BRPI0915397B8/pt
Priority to ES09770498T priority patent/ES2821448T3/es
Priority to US13/000,811 priority patent/US9242036B2/en
Priority to RU2011102164/05A priority patent/RU2514956C2/ru
Publication of WO2009157877A1 publication Critical patent/WO2009157877A1/en
Anticipated expiration legal-status Critical
Priority to US14/982,482 priority patent/US20160151555A1/en
Priority to US16/792,774 priority patent/US11590272B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
    • A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/206—Packing or coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/0203—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04
    • B01J20/0211—Compounds of Ti, Zr, Hf
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/06—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/20—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbon; comprising carbon obtained by carbonising processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • B01J20/28035—Membrane, sheet, cloth, pad, lamellar or mat with more than one layer, e.g. laminates, separated sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28052—Several layers of identical or different sorbents stacked in a housing, e.g. in a column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/12—Compounds containing phosphorus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/08—Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/10—Inorganic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
    • B01J2220/46—Materials comprising a mixture of inorganic and organic materials

Definitions

  • the disclosed sorbent may further comprise a layer of anion exchange particles intermixed with organic compound absorbent particles.
  • the presence of the two layers of intermixtures reduces the overall size and height of the sorbent, facilitates the sorbent production and reduces the overall pressure drop caused by the sorbent when used in the dialysis device.
  • this increases the portability and user comfort of the sorbent without adversely affecting the efficiency with which metabolic waste products are removed by the sorbent.
  • Fig. 2c is a cross sectional view of a CAD of another embodiment of the sorbent cartridge having partitions to demarcate the different layers of the sorbent .
  • Fig. 3 shows a polycarpolactone (PCL) scaffold for use as a biocompatible substrate for the immobilization of urease as disclosed herein.
  • PCL polycarpolactone
  • Fig. 4 shows a polycarpolactone (PCL) scaffold for use as a biocompatible substrate for the immobilization of zirconium phosphate as disclosed herein.
  • the capacity of activated carbon to absorb creatinine is shown to be dependent on the flow rate of dialysate and on the particle size of the carbon under consideration. Crucially, there is a tendency for higher capacity, and increasing pressure drop with smaller particle size. The optimum between acceptable pressure drop and maximum absorbance is at a particle size range of 50 - 100 ⁇ m as shown in the experimental results tabulated below.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • External Artificial Organs (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
PCT/SG2009/000229 2008-06-23 2009-06-22 A sorbent for a dialysis device Ceased WO2009157877A1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ES09770498T ES2821448T3 (es) 2008-06-23 2009-06-22 Sorbente para un dispositivo de diálisis
BRPI0915397A BRPI0915397B8 (pt) 2008-06-23 2009-06-22 sorvente para um dispositivo de díalise
JP2011516227A JP2011525403A (ja) 2008-06-23 2009-06-22 透析装置用吸着剤
CN2009801323271A CN102123749A (zh) 2008-06-23 2009-06-22 用于透析设备的吸附剂
AU2009263045A AU2009263045B2 (en) 2008-06-23 2009-06-22 A sorbent for a dialysis device
NZ590467A NZ590467A (en) 2008-06-23 2009-06-22 A sorbent for a dialysis device where the pressure drop over across the layer is dependent of the size of the particles in the primary layer of immbolized uremic toxin-treating enzyme particles intermixed with cation exchange particles
US13/000,811 US9242036B2 (en) 2008-06-23 2009-06-22 Sorbent for a dialysis device
EP09770498.5A EP2303354B1 (en) 2008-06-23 2009-06-22 A sorbent for a dialysis device
RU2011102164/05A RU2514956C2 (ru) 2008-06-23 2009-06-22 Сорбент для диализа
US14/982,482 US20160151555A1 (en) 2008-06-23 2015-12-29 Sorbent for a dialysis device
US16/792,774 US11590272B2 (en) 2008-06-23 2020-02-17 Sorbent for a dialysis device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7499708P 2008-06-23 2008-06-23
US61/074,997 2008-06-23

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/000,811 A-371-Of-International US9242036B2 (en) 2008-06-23 2009-06-22 Sorbent for a dialysis device
US14/982,482 Continuation US20160151555A1 (en) 2008-06-23 2015-12-29 Sorbent for a dialysis device

Publications (1)

Publication Number Publication Date
WO2009157877A1 true WO2009157877A1 (en) 2009-12-30

Family

ID=41444786

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/SG2009/000230 Ceased WO2009157878A1 (en) 2008-06-23 2009-06-22 A flow system of a dialysis device and a portable dialysis device
PCT/SG2009/000229 Ceased WO2009157877A1 (en) 2008-06-23 2009-06-22 A sorbent for a dialysis device

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/SG2009/000230 Ceased WO2009157878A1 (en) 2008-06-23 2009-06-22 A flow system of a dialysis device and a portable dialysis device

Country Status (11)

Country Link
US (4) US9067017B2 (enExample)
EP (2) EP2310069B1 (enExample)
JP (4) JP5439482B2 (enExample)
CN (3) CN102176934B (enExample)
AU (2) AU2009263045B2 (enExample)
BR (2) BRPI0915400A2 (enExample)
ES (2) ES2821448T3 (enExample)
NZ (2) NZ590467A (enExample)
RU (2) RU2525205C2 (enExample)
TW (2) TW201014622A (enExample)
WO (2) WO2009157878A1 (enExample)

Cited By (91)

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Publication number Priority date Publication date Assignee Title
CN102858437A (zh) * 2010-02-19 2013-01-02 淡马锡理工学院 用于固定功能性物质的底物及其制备方法
CN102971023A (zh) * 2010-07-05 2013-03-13 甘布罗伦迪亚股份公司 非卧床式超滤装置、涉及的方法和计算机程序产品
WO2013101888A1 (en) * 2011-12-29 2013-07-04 Fresenius Medical Care Holdings, Inc. Materials for removal of toxins in sorbent dialysis and methods and systems using same
EP2740502A1 (en) 2012-12-10 2014-06-11 Medtronic Inc. Potassium loaded ion-exchange material for use in a dialysate regeneration system
EP2762178A1 (en) 2013-02-02 2014-08-06 Medtronic Inc. Sorbent cartridge configurations for improved dialysate regeneration
WO2014121168A1 (en) 2013-02-02 2014-08-07 Medtronic, Inc. Sodium management system for hemodialysis
WO2014121159A1 (en) 2013-02-01 2014-08-07 Medtronic, Inc. Fluid circuits for sorbent cartridges with sensors
WO2014121160A1 (en) 2013-02-01 2014-08-07 Medtronic, Inc. Sorbent cartridge with electrodes
US9017277B2 (en) 2011-05-02 2015-04-28 Medtronic, Inc. System and implantable device for treating chronic kidney disease
DE102013021957A1 (de) 2013-12-20 2015-06-25 Fresenius Medical Care Deutschland Gmbh Verfahren zur Entfernung proteingebundener Urämietoxine durch Adsorption an dialysierbare Hilfsstoffe
US9157786B2 (en) 2012-12-24 2015-10-13 Fresenius Medical Care Holdings, Inc. Load suspension and weighing system for a dialysis machine reservoir
WO2015162593A1 (en) 2014-04-25 2015-10-29 Debiotech S.A. Hemodialysis systems
US9192707B2 (en) 2011-04-29 2015-11-24 Medtronic, Inc. Electrolyte and pH monitoring for fluid removal processes
US9289165B2 (en) 2005-02-07 2016-03-22 Medtronic, Inc. Ion imbalance detector
US9308307B2 (en) 2007-09-13 2016-04-12 Fresenius Medical Care Holdings, Inc. Manifold diaphragms
WO2016057271A1 (en) * 2014-10-06 2016-04-14 Kci Licensing, Inc. Ion exchange absorbent systems, apparatuses
US9352282B2 (en) 2007-09-25 2016-05-31 Fresenius Medical Care Holdings, Inc. Manifolds for use in conducting dialysis
US9354640B2 (en) 2013-11-11 2016-05-31 Fresenius Medical Care Holdings, Inc. Smart actuator for valve
US9358331B2 (en) 2007-09-13 2016-06-07 Fresenius Medical Care Holdings, Inc. Portable dialysis machine with improved reservoir heating system
US9360129B2 (en) 2009-01-12 2016-06-07 Fresenius Medical Care Holdings, Inc. Valve system
US9415152B2 (en) 2007-11-29 2016-08-16 Fresenius Medical Care Holdings, Inc. Disposable apparatus and kit for conducting dialysis
US9456755B2 (en) 2011-04-29 2016-10-04 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9517296B2 (en) 2007-09-13 2016-12-13 Fresenius Medical Care Holdings, Inc. Portable dialysis machine
US9526822B2 (en) 2013-02-01 2016-12-27 Medtronic, Inc. Sodium and buffer source cartridges for use in a modular controlled compliant flow path
US9623164B2 (en) 2013-02-01 2017-04-18 Medtronic, Inc. Systems and methods for multifunctional volumetric fluid control
EP3165245A1 (en) 2011-08-02 2017-05-10 Medtronic, Inc. Hemodialysis system having a flow path with a controlled compliant volume
US9707328B2 (en) 2013-01-09 2017-07-18 Medtronic, Inc. Sorbent cartridge to measure solute concentrations
US9713668B2 (en) 2012-01-04 2017-07-25 Medtronic, Inc. Multi-staged filtration system for blood fluid removal
US9713666B2 (en) 2013-01-09 2017-07-25 Medtronic, Inc. Recirculating dialysate fluid circuit for blood measurement
US9713665B2 (en) 2014-12-10 2017-07-25 Medtronic, Inc. Degassing system for dialysis
US9759710B2 (en) 2008-09-12 2017-09-12 Fresenius Medical Care Holdings, Inc. Modular reservoir assembly for a hemodialysis and hemofiltration system
EP3219341A1 (en) 2013-02-02 2017-09-20 Medtronic Inc. Ph and buffer management system for hemodialysis systems
US9827361B2 (en) 2013-02-02 2017-11-28 Medtronic, Inc. pH buffer measurement system for hemodialysis systems
US9848778B2 (en) 2011-04-29 2017-12-26 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9867918B2 (en) 2014-03-17 2018-01-16 Fresenius Medical Care Holdings, Inc. Cartridges useful in cleaning dialysis solutions
US9884145B2 (en) 2013-11-26 2018-02-06 Medtronic, Inc. Parallel modules for in-line recharging of sorbents using alternate duty cycles
US9895477B2 (en) 2013-11-26 2018-02-20 Medtronic, Inc. Detachable module for recharging sorbent materials with optional bypass
US9895479B2 (en) 2014-12-10 2018-02-20 Medtronic, Inc. Water management system for use in dialysis
US9943633B2 (en) 2009-09-30 2018-04-17 Medtronic Inc. System and method to regulate ultrafiltration
US9943780B2 (en) 2013-11-26 2018-04-17 Medtronic, Inc. Module for in-line recharging of sorbent materials with optional bypass
WO2018106185A2 (en) 2016-12-05 2018-06-14 Temasek Polytechnic Sorbent for a dialysis device and dialysis system
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