RU2011102164A - Сорбент для диализа - Google Patents

Сорбент для диализа Download PDF

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RU2011102164A
RU2011102164A RU2011102164/05A RU2011102164A RU2011102164A RU 2011102164 A RU2011102164 A RU 2011102164A RU 2011102164/05 A RU2011102164/05 A RU 2011102164/05A RU 2011102164 A RU2011102164 A RU 2011102164A RU 2011102164 A RU2011102164 A RU 2011102164A
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sorbent
particles
sorbent according
layer
cation exchangers
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RU2514956C2 (ru
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Кристиан Герт БЛУЧЕЛ (SG)
Кристиан Герт БЛУЧЕЛ
Йанмэй ВАНГ (SG)
Йанмэй ВАНГ
Ким Ченг ТАН (SG)
Ким Ченг ТАН
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Темасек Политехник (Sg)
Темасек Политехник
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
    • A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/206—Packing or coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/0203—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04
    • B01J20/0211—Compounds of Ti, Zr, Hf
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/06—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/20—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbon; comprising carbon obtained by carbonising processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • B01J20/28035—Membrane, sheet, cloth, pad, lamellar or mat with more than one layer, e.g. laminates, separated sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28052—Several layers of identical or different sorbents stacked in a housing, e.g. in a column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/12—Compounds containing phosphorus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/08—Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/10—Inorganic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
    • B01J2220/46—Materials comprising a mixture of inorganic and organic materials

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • External Artificial Organs (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

1. Сорбент для удаления метаболических отходов из диалитической жидкости, включающий первый слой, состоящий из частиц иммобилизированного фермента, расщепляющего уремические токсины, смешанных с катионообменниками, ! отличающийся тем, что первый слой расположен внутри сорбента таким образом, что при его использовании потери давления диализата в первом слое зависят от размера частиц указанных катионообменников. ! 2. Сорбент по п.1, отличающийся тем, что он дополнительно включает второй слой, состоящий из катионообменников. ! 3. Сорбент по п.2, отличающийся тем, что он дополнительно включает третий слой, состоящий из анионообменников, смешанных с частицами, абсорбирующими органические смеси. ! 4. Сорбент по п.3, отличающийся тем, что второй слой располагают между указанным первым слоем и указанным третьим слоем. ! 5. Сорбент по п.1, отличающийся тем, что указанные частицы фермента, расщепляющего уремические токсины, преобразуют мочевину в карбонат аммония. ! 6. Сорбент по п.5, отличающийся тем, что указанным ферментом, расщепляющим уремические токсины, является уреаза. ! 7. Сорбент по любому из пп.1 или 2, отличающийся тем, что указанными катионообменниками являются частицы фосфата циркония. ! 8. Сорбент по п.3, отличающийся тем, что указанными анионообменниками являются частицы оксида циркония. ! 9. Сорбент по п.3, отличающийся тем, что указанными частицами, абсорбирующими органические смеси, являются частицы активированного угля. ! 10. Сорбент по п.6, отличающийся тем, что уреазу иммобилизуют при помощи как минимум одного из следующих веществ: целлюлоза, нейлон, поликапролактон, хитозан. ! 11. Сорбент по п.8, отличающийся тем, чт

Claims (20)

1. Сорбент для удаления метаболических отходов из диалитической жидкости, включающий первый слой, состоящий из частиц иммобилизированного фермента, расщепляющего уремические токсины, смешанных с катионообменниками,
отличающийся тем, что первый слой расположен внутри сорбента таким образом, что при его использовании потери давления диализата в первом слое зависят от размера частиц указанных катионообменников.
2. Сорбент по п.1, отличающийся тем, что он дополнительно включает второй слой, состоящий из катионообменников.
3. Сорбент по п.2, отличающийся тем, что он дополнительно включает третий слой, состоящий из анионообменников, смешанных с частицами, абсорбирующими органические смеси.
4. Сорбент по п.3, отличающийся тем, что второй слой располагают между указанным первым слоем и указанным третьим слоем.
5. Сорбент по п.1, отличающийся тем, что указанные частицы фермента, расщепляющего уремические токсины, преобразуют мочевину в карбонат аммония.
6. Сорбент по п.5, отличающийся тем, что указанным ферментом, расщепляющим уремические токсины, является уреаза.
7. Сорбент по любому из пп.1 или 2, отличающийся тем, что указанными катионообменниками являются частицы фосфата циркония.
8. Сорбент по п.3, отличающийся тем, что указанными анионообменниками являются частицы оксида циркония.
9. Сорбент по п.3, отличающийся тем, что указанными частицами, абсорбирующими органические смеси, являются частицы активированного угля.
10. Сорбент по п.6, отличающийся тем, что уреазу иммобилизуют при помощи как минимум одного из следующих веществ: целлюлоза, нейлон, поликапролактон, хитозан.
11. Сорбент по п.8, отличающийся тем, что указанным оксидом циркония является гидратированный оксид циркония.
12. Сорбент по п.6, отличающийся тем, что средний размер указанных частиц уреазы составляет от 10 мкм до 1000 мкм.
13. Сорбент по п.7, отличающийся тем, что средний размер указанных частиц фосфата циркония составляет от 10 мкм до 1000 мкм.
14. Сорбент по п.8, отличающийся тем, что средний размер указанных частиц оксида циркония составляет от 10 мкм до 1000 мкм.
15. Сорбент по п.9, отличающийся тем, что средний размер указанных частиц активированного угля составляет от 10 мкм до 1000 мкм.
16. Сорбент для удаления метаболических отходов из диалитической жидкости, включающий слой катионообменников, средний размер частиц которых составляет от 50 мкм до 200 мкм.
17. Сорбент для удаления метаболических отходов из диалитической жидкости, включающий:
первый слой, состоящий из частиц иммобилизированного фермента, расщепляющего уремические токсины, смешанных с катионообменниками; и
второго слоя, состоящего из катионообменников.
18. Сорбент по п.17, отличающийся тем, что средний размер указанных катионообменников составляет от 10 мкм до 1000 мкм.
19. Сорбент по любому из пп.1, 2, 17 или 18, отличающийся тем, что указанными катионообменниками являются абсорбенты аммиака.
20. Сорбент по любому из пп.1, 2, 17 или 18, отличающийся тем, что указанные катионообменники включают ионы металла, фосфат которого слаборастворим в воде.
RU2011102164/05A 2008-06-23 2009-06-22 Сорбент для диализа RU2514956C2 (ru)

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US7499708P 2008-06-23 2008-06-23
US61/074,997 2008-06-23
PCT/SG2009/000229 WO2009157877A1 (en) 2008-06-23 2009-06-22 A sorbent for a dialysis device

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RU2514956C2 RU2514956C2 (ru) 2014-05-10

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US (4) US9242036B2 (ru)
EP (2) EP2310069B1 (ru)
JP (4) JP2011525403A (ru)
CN (3) CN106111079A (ru)
AU (2) AU2009263046B2 (ru)
BR (2) BRPI0915400A2 (ru)
ES (2) ES2821448T3 (ru)
NZ (2) NZ590471A (ru)
RU (2) RU2514956C2 (ru)
TW (2) TW201014622A (ru)
WO (2) WO2009157877A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
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RU2635143C1 (ru) * 2014-03-17 2017-11-09 Фрезениус Медикал Кеа Холдингс, Инк. Картриджи, которые можно использовать в очищающих растворах для диализа

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US20060217771A1 (en) 2005-02-07 2006-09-28 Medtronic, Inc. Potassium monitoring
ES2608399T3 (es) 2005-12-13 2017-04-10 Exthera Medical Corporation Método para la eliminación extracorpórea de un microbio patógeno, una célula inflamatoria o una proteína inflamatoria de la sangre
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JP2015013129A (ja) 2015-01-22
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