JP2013520226A - 機能性物質を固定化するための基材、およびそれを作製するための方法 - Google Patents
機能性物質を固定化するための基材、およびそれを作製するための方法 Download PDFInfo
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- 235000013343 vitamin Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 108010062040 wax-ester hydrolase Proteins 0.000 description 1
- 108010068608 xanthan lyase Proteins 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
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Abstract
Description
(i)膜表面へ求電子化合物をカップリングさせる工程、
(ii)求電子化合物に求核置換反応を起こさせることでその上へ求核基を提供し、それによって膜表面の求核性を増加させる工程、
(iii)求核基に別の求電子化合物との求核置換反応を起こさせることで膜表面上に求電子基を提供し、それによってその上に機能性分子を固定化するための膜表面の求電子性を増加させる工程、
を含む。
XおよびYは、独立して、NH、NR、NHO、NRO、O、S、Se、COO、CONH、CONR、CSS、COS、CONHO、CONRO、CONHNH、CONRNH、CONRNR、CNO、PH、およびPRから選択され、
Rは、水素、所望に応じて置換されていてよいアルキル、所望に応じて置換されていてよいアルケニル、所望に応じて置換されていてよいアルキニル、所望に応じて置換されていてよいアリール、および所望に応じて置換されていてよいヘテロアリールからなる群より選択され、ならびに
nは、0から25までの整数である)
を有していてもよい。
XおよびYは、独立して、NH、NR、NHO、NRO、O、S、Se、COO、CONH、CONR、CSS、COS、CONHO、CONRO、CONHNH、CONRNH、CONRNR、CNO、PH、PRから選択され、
ここで、R、R1、R2、R3、R4は、独立して、水素、所望に応じて置換されていてよいアルキル、所望に応じて置換されていてよいアルケニル、所望に応じて置換されていてよいアルキニル、所望に応じて置換されていてよいアリール、および所望に応じて置換されていてよいヘテロアリールからなる群より選択され、ならびに
m、n、p、およびqは、独立して、0から25より選択される整数である)
を有していてもよい。
本明細書で用いられる以下の単語および用語は、示した意味を有するものとする。
XおよびYは、独立して、NH、NR、O、S、COO、CONH、およびCONRから選択され、
Rは、水素、所望に応じて置換されていてよいアルキル、所望に応じて置換されていてよいアルケニル、所望に応じて置換されていてよいアルキニル、所望に応じて置換されていてよいアリール、および所望に応じて置換されていてよいヘテロアリールからなる群より選択され、ならびに
nは、0から25までの整数である)
を有していてよい。
XおよびYは、独立して、NH、NR、NHO、NRO、O、S、Se、COO、CONH、CONR、CSS、COS、CONHO、CONRO、CONHNH、CONRNH、CONRNR、CNO、PH、PRから選択され、
R、R1、R2、R3、R4は、独立して、水素、所望に応じて置換されていてよいアルキル、所望に応じて置換されていてよいアルケニル、所望に応じて置換されていてよいアルキニル、所望に応じて置換されていてよいアリール、および所望に応じて置換されていてよいヘテロアリールからなる群より選択され、ならびに
m、n、p、およびqは、独立して、0から25より選択される整数である)
を有していてもよい。
XおよびYは、独立して、NR1R2、NRO、OR、SR、SeR、COOR、CONR、CSSR、COSR、CONRO、CONRNR1R2、CNOR、およびPR1R2、ならびにカチオン性付加体を形成することができるその他のいずれかの置換基からなる群より選択され、
R、R1、およびR2は、独立して、水素、所望に応じて置換されていてよいアルキル、所望に応じて置換されていてよいアルケニル、所望に応じて置換されていてよいアルキニル、所望に応じて置換されていてよいアリール、および所望に応じて置換されていてよいヘテロアリールからなる群より選択され、ならびに
nは、0から25までの整数である)
を有する。
Xは、NH、NR、O、S、Se、COO、CONR1NR2、CONRO、CONH、およびCONRから選択され;R1およびR2は、独立して、水素、所望に応じて置換されていてよいアルキル、所望に応じて置換されていてよいアルケニル、所望に応じて置換されていてよいアルキニル、所望に応じて置換されていてよいアリール、および所望に応じて置換されていてよいヘテロアリールからなる群より選択され、ならびに
nは、0から25までの整数である)
を有してもよい。
Xは、NH、NR、NHO、NRO、O、S、Se、COO、CONH、CONR、CSS、COS、CONHO、CONRO、CONHNH、CONRNH、CONRNR、CNO、PH、PRから選択され、
R、R1、R2、R3、R4は、独立して、水素、所望に応じて置換されていてよいアルキル、所望に応じて置換されていてよいアルケニル、所望に応じて置換されていてよいアルキニル、所望に応じて置換されていてよいアリール、および所望に応じて置換されていてよいヘテロアリールからなる群より選択され、ならびに
m、n、p、およびqは、独立して、0から25より選択される整数である)
を有していてもよい。
XおよびYは、独立して、NH、NR、NHO、NRO、O、S、Se、COO、CONH、CONR、CSS、COS、CONHO、CONRO、CONHNH、CONRNH、CONRNR、CNO、PH、PRから選択され、
R、R1、R2、R3、R4は、独立して、水素、所望に応じて置換されていてよいアルキル、所望に応じて置換されていてよいアルケニル、所望に応じて置換されていてよいアルキニル、所望に応じて置換されていてよいアリール、および所望に応じて置換されていてよいヘテロアリールからなる群より選択され、ならびに
m、n、p、およびqは、独立して、0から25より選択される整数である)
Xは、NH、NR、NHO、NRO、O、S、Se、COO、CONH、CONR、CSS、COS、CONHO、CONRO、CONHNH、CONRNH、CONRNR、CNO、PH、PRから選択され、
R、R1、R2、R3、R4は、独立して、水素、所望に応じて置換されていてよいアルキル、所望に応じて置換されていてよいアルケニル、所望に応じて置換されていてよいアルキニル、所望に応じて置換されていてよいアリール、および所望に応じて置換されていてよいヘテロアリールからなる群より選択され、ならびに
m、n、p、およびqは、独立して、0から25より選択される整数である)
<エポキシ官能化基材の作製>
2.4M水酸化ナトリウム100mL中のセルロース5.0gの懸濁液を激しく攪拌し、エピクロロヒドリン30mLにて55℃で4時間処理することにより、セルロースのマーセリゼーションおよびエポキシ官能化を行った。反応混合物を吸引ろ過し、固体残渣(「一次エポキシセルロース」)を超純水で洗浄した(3×50mL)。乾燥一次エポキシセルロースのエポキシ基付加量は、125μmol/gであった(表1参照)。
エポキシ基含有物質のサンプル(約1gの湿潤物)を、5mLの水に懸濁させる。必要に応じて、この懸濁液を中性pHまで0.01N HClで滴定する。この中性懸濁液を、1.3M チオスルホン酸ナトリウム水溶液の5mLで処理し、続いて、時折振とうしながら15分間インキュベートする。次に、この懸濁液を、ブロモフェノールブルーに対して0.01N HClにより滴定する。サンプル中に存在するエポキシ基の総量は、滴定で消費されたHClの量と同等である。乾燥物のエポキシ付加量は、湿潤物の既知の水分含有量(LOD)に基づいて算出される。代表的な実験値を表1にまとめる。
<ウレアーゼの固定化>
実施例1で作製した二次エポキシセルロース(12.5gの湿潤物)を、pH7.5の1.0M リン酸カリウムバッファー150mL中のタチナタマメウレアーゼ(4.2g)の冷却溶液中に懸濁した。固定化反応は、インキュ
ベーターシェーカー中、4℃にて24時間行った。
固定化ウレアーゼを、システイン(5mg/mL)、エチレンジアミン四酢酸(EDTA、1.0mM)、およびグルコース(0.2g/mL)の水溶液中に10分間浸漬し、続いて吸引ろ過し、24時間凍結乾燥した。
Claims (62)
- 機能性分子を固定化するための化合物がその上に配置された基材であって、各々の化合物は:
前記基材へ化学的にカップリングされた部分Rであって、前記部分Rは、エーテル、エステル、カルボニル、カーボネートエステル、チオエーテル、ジスルフィド、スルフィニル、スルホニル、およびカルボノチオイルからなる群より選択される、部分R;ならびに、
少なくとも1つの求核基を含むリンカーによって前記部分Rへカップリングされたエポキシド含有部分、
を含む鎖を有する、基材。 - 前記部分Rが、アミン、アミド、カルバミド、尿素、およびグアニジンからなる群よりさらに選択される、請求項1に記載の基材。
- 前記鎖へカップリングされた追加のエポキシド含有基を含む、請求項1または請求項2に記載の基材。
- 追加のエポキシド含有基の数が、1、2、3、4、および5の数から選択される、請求項3に記載の基材。
- 前記追加のエポキシド含有基の少なくとも1つが、前記リンカーの前記求核基によって前記鎖へカップリングされる、請求項3または4に記載の基材。
- 前記リンカーが、それを介して前記追加のエポキシド含有基が前記鎖へカップリングされる追加の求核基を含む、請求項4または請求項5に記載の基材。
- 前記追加のエポキシド含有基が、前記リンカーの前記追加の求核基とカップリングすることによって前記鎖から分岐している、請求項6に記載の基材。
- 前記リンカーの前記求核基が、アミンである、請求項1から7のいずれか一項に記載の基材。
- 前記リンカーが、飽和および不飽和の脂肪族および芳香族アミン、ジアミン、ならびにトリアミンからなる群より選択される、請求項1から8のいずれか一項に記載の基材。
- 前記アミンの脂肪族基が、アルキル基である、請求項9に記載の基材。
- 前記リンカーが、エポキシド基を含有する、請求項1から10のいずれか一項に記載の基材。
- 前記リンカーが、二求核性種(di-nucleophilic species)および多求核性種(poly-nucleophilic species)の少なくとも1つを含む、請求項1から11のいずれか一項に記載の基材。
- 前記リンカーが、アルキル−ジアミンおよびアルケン−ジアミンの少なくとも1つから選択される、請求項12に記載の基材。
- 前記リンカーが、エタン−ジアミン、プロパン−ジアミン、ブタン−ジアミン、ペンタン−ジアミン、ヘキサン−ジアミンの少なくとも1つから選択される、請求項13に記載の基材。
- 前記エポキシド含有化合物が、エピハロヒドリンと前記リンカーの前記求核基との反応によって得られる、請求項1から14のいずれか一項に記載の基材。
- 前記基材が、ポリマーを含む、請求項1から15のいずれか一項に記載の基材。
- 前記ポリマーが、生体適合性ポリマーである、請求項16に記載の基材。
- 前記生体適合性ポリマーが、ポリエステル基材、ポリアミド基材、ポリアクリレート基材、およびポリサッカリド系基材からなる群より選択される、請求項17に記載の基材。
- 前記ポリサッカリド系基材が、コットンリンター、コットンパルプ、コットン布地、セルロース繊維、セルロースビーズ、セルロース粉末、微結晶セルロース、セルロース膜、レーヨン、セロファン、酢酸セルロース、酢酸セルロース膜、キトサン、キチン、デキストラン誘導体、およびアガロース誘導体からなる群より選択される、請求項17に記載の基材。
- 前記ポリマーが、バイオポリマーである、請求項16に記載の基材。
- 前記基材上に配置されたコーティングをさらに含み、前記コーティングは、前記機能性分子を安定化するために選択された安定化添加剤の実質的に均質である混合物を含む、請求項1から20のいずれか一項に記載の基材。
- 前記安定化添加剤が、糖、有機酸、アミノ酸、糖酸、およびチオールからなる群より選択される、請求項21に記載の基材。
- 機能性分子を基材上へ固定化する方法であって、前記機能性分子を、請求項1から22のいずれか一項に記載の基材へ曝露する工程を含む、方法。
- 前記機能性分子が、親和性リガンド、キレート剤、触媒、イオン交換体、色素、指示薬からなる群より選択される、請求項23に記載の方法。
- 前記機能性分子が、キラルである、請求項23または請求項24に記載の方法。
- 前記機能性分子が、生体分子である、請求項24に記載の方法。
- 前記生体分子が、酵素である、請求項26に記載の方法。
- 前記酵素が、ウレアーゼ、ウリカーゼ、クレアチニナーゼ、リパーゼ、エステラーゼ、セルラーゼ、アミラーゼ、ペクチナーゼ、カタラーゼ、アシラーゼ、カタラーゼ、エステラーゼ、ペニシリンアミダーゼ、プロテイナーゼ−Kからなる群より選択される、請求項27に記載の方法。
- 安定化添加剤の実質的に均質である混合物を、前記基材の表面へ適用する工程をさらに含み、ここで、前記添加剤は、前記機能性分子を安定化するために選択される、請求項23から28のいずれか一項に記載の方法。
- 前記添加剤の実質的に均質である混合物を適用する工程が、前記添加剤の溶液の溶媒を前記基材上にて蒸発させることを含む、請求項29に記載の方法。
- 前記安定化添加剤が、糖、有機酸、アミノ酸、糖酸、およびチオールからなる群より選択される、請求項29または30に記載の方法。
- その上へ機能性分子を固定化するための基材を作製する方法であって、前記方法は:
(i)前記基材の表面にカップリングした求電子化合物を提供する工程;
(ii)前記求電子化合物に求核置換反応を起こさせることでその上へ求核基を提供し、それによって前記基材表面の求核性を増加させる工程;
(iii)前記求核基に別の求電子化合物との求核置換反応を起こさせることで前記基材表面上に求電子基を提供し、それによって前記基材の求電子性を増加させる工程、
を含む、方法。 - 工程(ii)および(iii)が、n回繰り返され、前記基材上にn世代分の求電子基が形成される、請求項32に記載の方法。
- 前記基材の表面へカップリングした求電子化合物を提供する前記工程が、前記基材へ第一の求電子化合物を化学的にカップリングさせることを含む、請求項32または請求項33に記載の方法。
- 前記工程(ii)が、求核体を前記第一の求電子化合物と反応させる工程を含む、請求項34に記載の方法。
- 工程(iii)が、第二の求電子化合物を前記求核体へ化学的にカップリングさせることを含む、請求項35に記載の方法。
- 前記求電子化合物が、エポキシド含有化合物である、請求項32から36のいずれか一項に記載の方法。
- 前記エポキシド含有化合物が、エピハロヒドリンである、請求項37に記載の方法。
- 前記求核体が、二求核体(di-nucleophile)である、請求項32から38のいずれか一項に記載の方法。
- 前記求核体が、アミンを含む、請求項39に記載の方法。
- 前記アミンが、飽和および不飽和の脂肪族または芳香族アミン、ならびにポリアミンからなる群より選択される、請求項40に記載の方法。
- 前記アミンおよびポリアミンの脂肪族基が、アルキル基から選択される、請求項41に記載の方法。
- 前記ポリアミンが、エタン−ジアミン、プロパン−ジアミン、ブタン−ジアミン、ペンタン−ジアミン、ヘキサン−ジアミンの少なくとも1つから選択される、請求項42に記載の方法。
- 前記基材が、ポリマーを含む、請求項32から43のいずれか一項に記載の方法。
- 前記ポリマーが、生体適合性ポリマーである、請求項44に記載の方法。
- 前記生体適合性ポリマーが、ポリエステル基材、ポリアミド基材、ポリアクリレート基材、およびポリサッカリド系基材からなる群より選択される、請求項45に記載の方法。
- 前記ポリサッカリド系基材が、コットンリンター、コットンパルプ、コットン布地、セルロース繊維、セルロースビーズ、セルロース粉末、微結晶セルロース、セルロース膜、レーヨン、セロファン、酢酸セルロース、酢酸セルロース膜、キトサン、キチン、デキストラン誘導体、およびアガロース誘導体からなる群より選択される、請求項46に記載の方法。
- 前記ポリマーが、バイオポリマーである、請求項47に記載の方法。
- 前記機能性分子が、親和性リガンド、キレート剤、触媒、イオン交換体、色素、および指示薬からなる群より選択される、請求項33から49のいずれか一項に記載の方法。
- 前記機能性分子が、キラルである、請求項49に記載の方法。
- 前記機能性分子が、生体分子である、請求項49に記載の方法。
- 前記生体分子が、酵素である、請求項51に記載の方法。
- 前記酵素が、ウレアーゼ、ウリカーゼ、クレアチニナーゼ、リパーゼ、エステラーゼ、セルラーゼ、アミラーゼ、ペクチナーゼ、カタラーゼ、アシラーゼ、カタラーゼ、エステラーゼ、ペニシリンアミダーゼ、プロテイナーゼ−Kからなる群より選択される、請求項52に記載の方法。
- 安定化添加剤の実質的に均質である混合物を、前記基材の表面へ適用する工程をさらに含み、ここで、前記安定化添加剤は、前記機能性分子を安定化するために選択される、請求項32から53のいずれか一項に記載の方法。
- 前記添加剤の実質的に均質な混合物を適用する工程が、前記添加剤の溶液の溶媒を前記基材上にて蒸発させることを含む、請求項54に記載の方法。
- 前記安定化添加剤が、糖、有機酸、アミノ酸、糖酸、およびチオールからなる群より選択される、請求項54または55に記載の方法。
- 透析装置に用いるための収着剤カートリッジであって、前記収着剤カートリッジは、ウレアーゼを固定化するための請求項1から23のいずれか一項に記載の基材を含む、収着剤カートリッジ。
- 透析装置に用いるための透析器であって、前記透析器は、ウレアーゼを固定化するための請求項1から22のいずれか一項に記載の基材を含む、透析器。
- 尿素を含有する透析液を、請求項1から22のいずれか一項に記載の基材に曝露する工程;および、
前記透析液を前記基材から除去する工程、
を含む、透析法。 - 透析装置における、請求項1から22のいずれか一項に記載の基材の使用。
- 機能性分子をその上に固定化するための透析膜を修飾する方法であって、前記方法は:
(iv)求電子化合物を前記膜表面にカップリングする工程;
(v)前記求電子化合物に求核置換反応を起こさせることでその上へ求核基を提供し、それによって前記膜表面の求核性を増加させる工程;および、
(vi)前記求核基に別の求電子化合物との求核置換反応を起こさせることで前記膜表面上に求電子基を提供し、それによって機能性分子をその上に固定化するための前記膜表面の求電子性を増加させる工程、
を含む、方法。 - 前記膜が、酢酸セルロース膜である、請求項61に記載の方法。
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AU2011218501B2 (en) | 2014-10-23 |
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ES2816224T3 (es) | 2021-03-31 |
US20140017761A1 (en) | 2014-01-16 |
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