BR0106969A - Método de fabricação de um substrato multicelular e substrato multicelular - Google Patents

Método de fabricação de um substrato multicelular e substrato multicelular

Info

Publication number
BR0106969A
BR0106969A BR0106969-1A BR0106969A BR0106969A BR 0106969 A BR0106969 A BR 0106969A BR 0106969 A BR0106969 A BR 0106969A BR 0106969 A BR0106969 A BR 0106969A
Authority
BR
Brazil
Prior art keywords
substrate
luminescent
multicellular
manufacturing
combination
Prior art date
Application number
BR0106969-1A
Other languages
English (en)
Inventor
Rita J Andreoli
Mark T Meyering
Murtaza Amin
Richard S Chesterton
Eugene Ostreicher
Original Assignee
Cuno Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cuno Inc filed Critical Cuno Inc
Publication of BR0106969A publication Critical patent/BR0106969A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00644—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00657—One-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B01J2219/00662—Two-dimensional arrays within two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Laminated Bodies (AREA)

Abstract

"MéTODO DE FABRICAçãO DE UM SUBSTRATO MULTICELULAR NãO LUMINESCENTE E SUBSTRATO MULTICELULAR". Revela-se uma combinação aperfeiçoada de membrana microporosa não luminescente e suporte sólido para ser utilizada em aplicações de diagnóstico microanalítico. Especificamente, um substrato multicelular não luminescente possuindo uma membrana formada por um processo de inversão de fase efetivamente anexada, por união covalente através de um tratamento de superfície, a um substrato que prepara o substrato para se unir de modo suficiente e covalente à membrana microporosa não luminescente formada por um processo de inversão de fase, de modo tal que a combinação assim produzida é útil em aplicações de microarray, e no qual o substrato multicelular não luminescente de náilon é unido de modo covalente a um membro de base sólido, tal como, por exemplo, uma lâmina de microscópio de vidro ou de Mylar, de modo que a combinação assim produzida é útil em aplicações de microarray. Também são revelados aparelhos e métodos para a fabricação do substrato multicelular não luminescente.
BR0106969-1A 2000-07-05 2001-07-05 Método de fabricação de um substrato multicelular e substrato multicelular BR0106969A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21622900P 2000-07-05 2000-07-05
US21639000P 2000-07-06 2000-07-06
US22414100P 2000-08-10 2000-08-10
PCT/US2001/021262 WO2002002585A2 (en) 2000-07-05 2001-07-05 Low fluorescence nylon/glass composites for microdiagnostics

Publications (1)

Publication Number Publication Date
BR0106969A true BR0106969A (pt) 2004-07-13

Family

ID=27396248

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0106969-1A BR0106969A (pt) 2000-07-05 2001-07-05 Método de fabricação de um substrato multicelular e substrato multicelular

Country Status (6)

Country Link
US (2) US6734012B2 (pt)
EP (1) EP1297340A2 (pt)
JP (1) JP2004502928A (pt)
AU (1) AU780441B2 (pt)
BR (1) BR0106969A (pt)
WO (1) WO2002002585A2 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890483B2 (en) * 2000-07-05 2005-05-10 Cuno Incorporated Non-luminescent substrate
US20030219816A1 (en) * 2001-07-02 2003-11-27 Keith Solomon Composite microarray slides
EP1506088A2 (en) * 2002-01-24 2005-02-16 Pall Corporation Analysis device
AU2003212471A1 (en) * 2002-02-27 2003-09-09 Miragene, Inc. Improved substrate chemistry for protein immobilization on a rigid support
US7597936B2 (en) * 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
US7682688B2 (en) * 2002-11-26 2010-03-23 University Of Utah Research Foundation Microporous materials, methods, and articles for localizing and quantifying analytes
US20050218067A1 (en) * 2003-04-10 2005-10-06 Cuno Incorporated Ablated predetermined surface geometric shaped boundary formed on porous material mounted on a substrate and methods of making same
US20050064431A1 (en) * 2003-09-09 2005-03-24 Eastman Kodak Company Biological microarray comprising polymer particles and method of use
TWI246593B (en) * 2003-11-12 2006-01-01 Ind Tech Res Inst Method and substrate for biochips by using single-step manufacturing process
US20060088857A1 (en) * 2003-12-01 2006-04-27 Said Attiya Method for isolation of independent, parallel chemical micro-reactions using a porous filter
US20070056898A1 (en) * 2004-05-13 2007-03-15 Keith Wesner Ablated predetermined surface geometric shaped boundary formed on porous material mounted on a substrate and methods of making same
FR2860802B1 (fr) * 2004-07-28 2008-02-22 Bertin Technologies Sa Methode pour permettre une lecture en chimiluminescence d'une puce
US20060108287A1 (en) * 2004-09-21 2006-05-25 Arnold Todd E Discrete zoned microporous nylon coated glass platform for use in microwell plates and methods of making and using same
DK1841757T3 (da) * 2005-01-07 2010-09-13 Pfizer Prod Inc Heteroaromatiske quinolin-forbindelser og deres anvendelse som PDE10-hæmmere
US20070023354A1 (en) * 2005-07-26 2007-02-01 Cuno Incorporated Methods and systems for dispersing ultrafine non-polar particles into a polymer/solvent/non-solvent solution and products formed thereby
CN101017174A (zh) * 2005-10-04 2007-08-15 米利波尔公司 蛋白质微阵列载物片
US7923054B2 (en) 2006-04-19 2011-04-12 Gore Enterprise Holdings, Inc. Functional porous substrates for attaching biomolecules
US7501250B2 (en) * 2006-09-26 2009-03-10 Chung-Cheng Chang Blotting method for rapidly analyzing nucleic acid
DE102010001322A1 (de) * 2010-01-28 2011-08-18 Siemens Aktiengesellschaft, 80333 Anordnung und Verfahren zur Filtration einer Flüssigkeit und Verwendung in der Mikroskopie
GB201002824D0 (en) 2010-02-19 2010-04-07 Temasek Polytechnic A method of preparing a substrate for immobilization of functional substances thereon and the substrate obtained therefrom
WO2012016480A1 (en) * 2010-08-06 2012-02-09 Delta Electronics, Inc. Process for manufacturing porous material
CN111603948B (zh) * 2020-05-21 2023-06-30 杭州科百特科技有限公司 一种尼龙膜及其制备方法和应用
CN113244794B (zh) * 2021-05-11 2022-04-19 燕山大学 截留硝酸盐的纳滤膜制备方法及浓缩液资源化利用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876738A (en) * 1973-07-18 1975-04-08 Amf Inc Process for producing microporous films and products
US3874986A (en) * 1974-05-20 1975-04-01 Gen Electric Laminated porous/non-porous membranes
US4473474A (en) 1980-10-27 1984-09-25 Amf Inc. Charge modified microporous membrane, process for charge modifying said membrane and process for filtration of fluid
US4711793A (en) 1980-10-27 1987-12-08 Cuno Incorporated Process for charge modifying a microphorous membrane
US4473475A (en) 1981-05-29 1984-09-25 Amf Inc. Charge modified microporous membrane, process for charge modifying said membrane, and process for filtration of fluids
US4707265A (en) 1981-12-18 1987-11-17 Cuno Incorporated Reinforced microporous membrane
US4645602A (en) 1981-12-18 1987-02-24 Barnes Jr Robert G Process for producing reinforced microporous membrane
US4921878A (en) 1987-06-05 1990-05-01 Pall Corporation Non-fluorescing, non-reflective polyamide for use in diagnostic testing
US4837162A (en) 1987-06-05 1989-06-06 Pall Corporation Non-fluorescing, non-reflective polyamide for use in diagnostic testing
US5006287A (en) 1988-01-14 1991-04-09 The Standard Oil Company Affinity membranes having pendant hydroxy groups and processes for the preparation and use thereof
DE3809523A1 (de) 1988-03-22 1989-10-12 Miles Inc Verfahren zur herstellung von poroesen membranen, die damit hergestellten membranen und deren verwendung als traegermatrices in teststreifen
US5062691A (en) 1989-10-27 1991-11-05 Minnesota Mining And Manufacturing Company Liquid crystal device with grey scale
US5667976A (en) 1990-05-11 1997-09-16 Becton Dickinson And Company Solid supports for nucleic acid hybridization assays
US5747244A (en) * 1991-12-23 1998-05-05 Chiron Corporation Nucleic acid probes immobilized on polystyrene surfaces
DE4238389A1 (de) 1992-11-13 1994-05-19 Bayer Ag Verfahren zur Durchführung immundiagnostischer Nachweise
AU675251B2 (en) 1993-01-04 1997-01-30 Becton Dickinson & Company Flow-through hybridization assay for oligonucleotide sequences
AU5495194A (en) 1993-02-26 1994-09-01 Becton Dickinson & Company Flow through membrane nucleic acid hybridization assay
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5688642A (en) * 1994-12-01 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Selective attachment of nucleic acid molecules to patterned self-assembled surfaces
US5601997A (en) * 1995-02-03 1997-02-11 Tchao; Ruy Chemotaxis assay procedure
US5858309A (en) * 1996-03-22 1999-01-12 Corning Incorporated Microplates with UV permeable bottom wells
US6056529A (en) 1998-02-11 2000-05-02 Cuno, Inc. Systems for producing a plurality of different microporous phase inversion membrane each having any one of a plurality of different pore sizes from a single master dope batch
US5976336A (en) * 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
US5760130A (en) 1997-05-13 1998-06-02 Molecular Dynamics, Inc. Aminosilane/carbodiimide coupling of DNA to glass substrate
US5919626A (en) 1997-06-06 1999-07-06 Orchid Bio Computer, Inc. Attachment of unmodified nucleic acids to silanized solid phase surfaces
US6066446A (en) * 1997-12-19 2000-05-23 Nen Life Science Products, Inc. Assay member and method for its manufacture
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6048695A (en) * 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
AU2001238359A1 (en) 2000-02-18 2001-08-27 Pall Corporation Membranes
US6413722B1 (en) 2000-03-22 2002-07-02 Incyte Genomics, Inc. Polymer coated surfaces for microarray applications

Also Published As

Publication number Publication date
US6734012B2 (en) 2004-05-11
AU780441B2 (en) 2005-03-24
US20020119559A1 (en) 2002-08-29
EP1297340A2 (en) 2003-04-02
WO2002002585A2 (en) 2002-01-10
WO2002002585A3 (en) 2002-10-03
US20040157320A1 (en) 2004-08-12
AU7183501A (en) 2002-01-14
JP2004502928A (ja) 2004-01-29

Similar Documents

Publication Publication Date Title
BR0106969A (pt) Método de fabricação de um substrato multicelular e substrato multicelular
BR0106975A (pt) Método de fabricação de um substrato cellular e substrato celular
EP2290068A3 (en) Methods and compositions involving microRNA
WO2005014035A3 (en) Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest
DE59403338D1 (de) Oleophob modifizierte mikroporöse Polymere
DK1218105T3 (da) Struktureret reaktionssubstrat
TW200730865A (en) Optical element, manufacturing process for this and composite combination of component with the optical element
DE60004934D1 (de) Silsesquioxan-Harz mit hoher Festigkeit und Bruchzähigkeit und Verfahren zu dessen Herstellung
TW200512270A (en) Pressure-sensitive adhesive sheet
DE602005021919D1 (de) Medizinische vorrichtungen und verfahren zu ihrer herstellung
DE60236814D1 (de) 3-alkyl-5,5',6,6',7,7',8,8'-octahydro-2,2'-binaphthole und 3,3'-dialkyl-5,5',6,6',7,7',8,8'-octahydro-2,2'-binaphthole, sowie verfahren zur ihrer herstellung
ATE304577T1 (de) Härtbare fluorelastomer-zusammensetzungen enthaltend hydrosiloxane oder hydrosilazane
BR0110402A (pt) Compostos
DE60229184D1 (de) Modifizierter kautschuk, verfahren zu dessen herstellung und zusammensetzung
ATE409178T1 (de) Verfahren zur produktion von iohexol hoher reinheit
WO2003012124A3 (en) Methods for immobilizing molecules to a solid phase and uses thereof
ITRM20020529A1 (it) Polimeri sterilizzanti, processo di loro preparazione ed uso.
FR2831534B1 (fr) Composition photoactivable et utilisations
DE50203232D1 (de) Verbund-Sicherheitsglas und Verfahren zu dessen Herstellung
DE50205517D1 (de) Polyorganosiloxan-zusammensetzung
WO2021228905A3 (en) Mutant polymerases and methods of using the same
WO2007000163A8 (en) Immobilisation of polypeptides by irradiation
PT1069985E (pt) Unioes de componentes polimeros isentas de cola para a producao de estruturas de micro- e nanocanais fechados
DE60020854D1 (de) Verfahren zur herstellung einer matrix und nach diesem verfahren hergestellte matrix
ATE362944T1 (de) Reaktive und gelfreie zusammensetzungen zur herstellung von hybridverbunden

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1963 DE 19.08.2008.