WO2009142269A1 - 芳香族カルボン酸の製造方法 - Google Patents
芳香族カルボン酸の製造方法 Download PDFInfo
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- WO2009142269A1 WO2009142269A1 PCT/JP2009/059366 JP2009059366W WO2009142269A1 WO 2009142269 A1 WO2009142269 A1 WO 2009142269A1 JP 2009059366 W JP2009059366 W JP 2009059366W WO 2009142269 A1 WO2009142269 A1 WO 2009142269A1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
- C07C51/21—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen
- C07C51/255—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of compounds containing six-membered aromatic rings without ring-splitting
- C07C51/265—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of compounds containing six-membered aromatic rings without ring-splitting having alkyl side chains which are oxidised to carboxyl groups
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Definitions
- an aromatic compound (such as an arene compound) having an alkyl group and / or an alkylene group is oxidized with molecular oxygen in a system having a small amount of a reaction solvent such as an organic solvent (particularly in the absence of the reaction solvent).
- a reaction solvent such as an organic solvent
- Aromatic carboxylic acids or derivatives thereof are used as raw materials for various resins, and are in great demand worldwide.
- terephthalic acid derived from p-xylene is used all over the world as a raw material for a highly versatile polyethylene terephthalate (PET) resin.
- PET polyethylene terephthalate
- pyromellitic anhydride derived from durene is used in a wide range of applications such as electronic materials.
- carboxylic acids or derivatives thereof are produced by oxygen oxidation of the corresponding aromatic compounds.
- carboxylic acids such as terephthalic acid are produced by an air oxidation method using a catalyst system containing a transition metal salt and bromine.
- a catalyst system containing a transition metal salt and bromine is produced by an air oxidation method using a catalyst system containing a transition metal salt and bromine.
- such a method has problems such as requiring a relatively high reaction temperature and corroding the apparatus with a halogen-based catalyst.
- Patent Document 1 discloses that when an organic compound is produced using an imide catalyst, the conversion rate of the substrate and / or the purpose is obtained by sequentially adding the imide catalyst to the reaction system. It has been disclosed to improve the selectivity of compounds. However, this method basically assumes that the reaction is performed in the presence of a solvent, and the purification efficiency is low.
- JP 2002-331242 A Patent Document 2 uses cyclohexane or the like efficiently in the absence of a solvent or in the case of using a low-polarity reaction solvent by using an imide catalyst having high fat solubility.
- JP 2001-354596 A (claim 1 and paragraph number [0007])
- JP 2002-331242 A (Claim 1 and paragraph number [0011])
- an object of the present invention is to provide a method capable of efficiently producing a desired aromatic carboxylic acid with enhanced catalytic activity.
- Another object of the present invention is to provide a method capable of producing an aromatic carboxylic acid with high productivity while allowing the oxidation reaction to proceed efficiently even with a relatively small amount of catalyst, with high purification efficiency. .
- the present inventors have identified (i) an aromatic compound having an alkyl group and / or an alkylene group in the absence of a solvent or in the presence of a small amount of solvent.
- the produced aromatic carboxylic acid forms a salt with the transition metal promoter, and this salt acts as an active species, or the oxidation reaction proceeds efficiently.
- the present inventors Since it is not necessary to remove a large amount of solvent components, the present inventors have found that purification efficiency is high and energy is advantageous.
- the present inventors also provide that (iii) when an imide catalyst is supplied to a reaction system sequentially or continuously together with a substrate, a reaction intermediate and / or a reaction product, the oxidation reaction is accelerated (iv) )
- imide radicals > N—O.
- imide radicals are well dispersed and can participate in the reaction efficiently, so that the oxidation reaction proceeds efficiently even with a small amount of catalyst
- (v) When an oxidation reaction is carried out without using an imide catalyst, a compound decarboxylated from the aromatic compound of the substrate is produced as a by-product, and the addition of the imide catalyst reduces the by-product of this by-product.
- the present invention has been completed.
- a catalyst composed of a nitrogen atom-containing cyclic compound containing a skeleton represented by the following formula (1) as a ring component (hereinafter simply referred to as a catalyst having a cyclic imino unit, an imide compound or a catalyst).
- a transition metal cocatalyst and oxygen oxidation of an aromatic compound having an alkyl group and / or an alkylene group as a substrate to produce a corresponding aromatic carboxylic acid The oxidation reaction is carried out while sequentially or continuously supplying a mixture of the substrate, a reaction intermediate produced by the oxidation reaction of the substrate, and at least one selected from the reaction product to the oxidation reaction system.
- X represents an oxygen atom or —OR group (R represents a hydrogen atom or hydroxyl protecting group), and the double line between the solid line and the broken line connecting “N” and “X” represents a single bond or a double bond. Indicates a double bond).
- the oxidation reaction is usually performed in the absence of a reaction solvent (not including the substrate, reaction intermediate, and reaction product). In the said manufacturing method, you may make it react, removing the water produced
- the component supplied to the reaction system together with the catalyst having a cyclic imino unit corresponds to (b-1) an aromatic compound having an alkyl group and / or alkylene group as a substrate, and (b-2) an aromatic compound as a substrate.
- a carbonyl compound for example, a reaction intermediate (eg, ketone, aldehyde, etc.), a reaction product (aromatic carboxylic acid, etc.)], and (b-3) at least one selected from water as a reaction product It may be used.
- the catalyst having a cyclic imino unit may be a water-soluble or water-dispersible imide compound, and the substrate has one or two C 1-4 alkyl groups and / or C 1-4 alkylene groups in the aromatic ring.
- generated by oxidation reaction may be able to form a salt with a transition metal promoter.
- the catalyst having a cyclic imino unit is at least one selected from alkanedicarboxylic imide, alkenecarboxylic imide, and isocyanuric acid having an oxygen atom or —OR group (R is the same as above) on at least one nitrogen atom.
- the transition metal promoter may contain at least a Group 9 metal component and a Group 7 metal component of the Periodic Table.
- the transition metal promoter may contain a cobalt compound and a manganese compound.
- aromatic carboxylic acid is not limited to a carboxylic acid having a free carboxyl group, but is a derivative of an aromatic carboxylic acid, for example, a compound having an acid anhydride group, a carboxylic acid ester [methyl ester , Lower alkyl esters such as ethyl ester (C 1-4 alkyl ester and the like)] and the like.
- reaction solvent does not include a substrate, reaction intermediate and reaction product, and mean components different from the substrate, reaction intermediate and reaction product. Therefore, the “substrate, reaction intermediate and reaction product” may exist as a medium in the reaction system.
- the imide catalyst is supplied to the reaction system sequentially or continuously together with the substrate, reaction intermediate and / or reaction product, the catalytic activity is increased and the target aromatic carboxylic acid is efficiently produced. Can be manufactured. Therefore, the oxidation reaction can proceed efficiently even with a relatively small amount of catalyst. Furthermore, the oxidation reaction does not use a reaction solvent (such as an organic solvent different from the substrate, reaction intermediate, and reaction product) that is usually used in the oxidation reaction, or a small amount of it can be used for purification. The efficiency can be improved and an aromatic carboxylic acid can be obtained with high productivity.
- a reaction solvent such as an organic solvent different from the substrate, reaction intermediate, and reaction product
- an aromatic compound having an alkyl group and / or an alkylene group as a substrate is oxygenated in the presence of a catalyst having a cyclic imino unit having a skeleton represented by the formula (1) and a transition metal promoter.
- a catalyst having a cyclic imino unit having a skeleton represented by the formula (1) and a transition metal promoter In the method of oxidizing and producing a corresponding aromatic carboxylic acid, a mixture of the catalyst and at least one selected from a substrate, a reaction intermediate and a reaction product is added to the oxidation reaction system sequentially or continuously. The oxidation reaction is carried out while supplying to the reactor.
- the imide compound is a compound having a cyclic imino unit having a skeleton represented by the formula (1) (skeleton (1)) as a ring component.
- the imide compound only needs to have at least one skeleton (1) in the molecule, and may have a plurality of skeletons (1). Further, the cyclic imino unit may constitute one ring with a plurality of skeletons (1) as a constituent element.
- the cyclic imino unit has one or a plurality of heteroatoms (for example, a nitrogen atom, a sulfur atom, an oxygen atom (particularly a nitrogen atom)) as a ring constituent atom in addition to the nitrogen atom of the skeleton (1). May be.
- heteroatoms for example, a nitrogen atom, a sulfur atom, an oxygen atom (particularly a nitrogen atom)
- X represents an oxygen atom, an —OH group or a hydroxyl group protected with a protecting group R.
- the protecting group include JP 2002-308805 (Patent Document 3), JP 2006-273793 (Patent Document 4), and WO 2002/040154 (Patent Document 5).
- the protective group R for example, an optionally substituted hydrocarbon group [alkyl group, alkenyl group (allyl group, etc.), cycloalkyl group, optionally substituted aryl group, substituent An aralkyl group etc.
- a group capable of forming an acetal or hemiacetal group with a hydroxyl group such as a substituted C 1-3 alkyl group (halo C 1-2 alkyl group (2,2,2- Trichloroethyl group, etc.), C 1-4 alkoxy C 1-2 alkyl group (methoxymethyl group, ethoxymethyl group, isopropoxymethyl group, 2-methoxyethyl group, 1-ethoxyethyl group, 1-isopropoxyethyl group, etc.) ), C 1-4 alkylthio C 1-2 alkyl groups corresponding to those C 1-4 alkoxy C 1-2 alkyl group, halo C 1-4 alkoxy C 1-2 a Alkyl group (2,2,2-trichloroethoxymethyl group, bis (2-chloroethoxy) methyl group, etc.), C 1-4 alkyl C 1-4 alkoxy C 1-2 alkyl group (1-methyl-1-methoxy) E
- C 6-12 aryl-carbonyl groups such as benzoyl and naphthoyl groups
- sulfonyl groups in which alkyl groups may be halogenated alkylsulfonyl groups such as methanesulfonyl groups and trifluoromethanesulfonyl groups
- benzenesulfonyl p- Toru Nsuruhoniru
- an arylsulfonyl group such as naphthalene sulfonyl group
- an alkoxycarbonyl group e.g., methoxycarbonyl group, C 1-4 alkoxy such as ethoxy carbonyl group - carbonyl group
- an aralkyloxycarbonyl group e.g., benzyloxycarbonyl Group, p-methoxybenzyloxycarbonyl group, etc.
- substituted or unsubstituted carbamoyl group C 1-4 alkylcarb
- R is a protecting group other than an alkyl group (such as a methyl group), such as a hydrogen atom; a group capable of forming an acetal or hemiacetal group with a hydroxyl group; a hydrolyzable protecting group that can be removed by hydrolysis, such as And groups obtained by removing the OH group from acids such as carboxylic acid, sulfonic acid, carbonic acid, carbamic acid, sulfuric acid, phosphoric acid and boric acid (acyl group, sulfonyl group, alkoxycarbonyl group, carbamoyl group, etc.).
- an alkyl group such as a methyl group
- a hydrolyzable protecting group that can be removed by hydrolysis, such as And groups obtained by removing the OH group from acids such as carboxylic acid, sulfonic acid, carbonic acid, carbamic acid, sulfuric acid, phospho
- the double line between the solid line and the broken line connecting the nitrogen atoms “N” and “X” represents a single bond or a double bond.
- Examples of the catalyst (imide compound) having a cyclic imino unit include a compound having a 5-membered or 6-membered cyclic unit containing the skeleton (1) as a ring component. Such compounds are known, and the above-mentioned Patent Documents 3 to 5 can be referred to.
- Examples of the compound having a 5-membered cyclic unit include a compound represented by the following formula (2).
- Examples of the compound having a 6-membered cyclic unit include the following formula (3) or (4 ) And the like.
- R 1 , R 2 and R 3 are the same or different and are a hydrogen atom, halogen atom, alkyl group, aryl group, cycloalkyl group, hydroxyl group, alkoxy group, carboxyl group, substituted oxycarbonyl group, acyl R 1 and R 2 may be bonded to each other to form an aromatic or non-aromatic ring, and R 2 and R 3 may be bonded to each other to form an aromatic group or an acyloxy group.
- a non-aromatic ring may be formed, and these rings may further have one or two of the above cyclic imino units.
- the double line between the solid line and the broken line is a single bond or a double bond.
- X 1 represents a hydrogen atom or X, and at least one X 1 is X.
- X is as defined above.
- the halogen atoms represented by the substituents R 1 , R 2 and R 3 include iodine, bromine, chlorine and fluorine atoms.
- the alkyl group include linear or branched C 1-20 alkyl groups such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, s-butyl, t-butyl, hexyl and decyl groups (especially C 1 -16 alkyl groups).
- Cycloalkyl groups include C 3-10 cycloalkyl groups such as cyclopentyl and cyclohexyl groups.
- Aryl groups include phenyl, naphthyl groups and the like.
- alkoxy group examples include linear or branched C 1 -1 such as methoxy, ethoxy, isopropoxy, butoxy, t-butoxy, hexyloxy, octyloxy, decyloxy, dodecyloxy, tetradecyloxy and octadecyloxy groups. 20 alkoxy groups (particularly C 1-16 alkoxy groups) are included.
- Examples of the substituted oxycarbonyl group include C 1-20 alkoxy-carbonyl groups such as methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, t-butoxycarbonyl, hexyloxycarbonyl, octyloxycarbonyl, decyloxycarbonyl group; C 3-10 cycloalkyloxy-carbonyl groups such as cyclopentyloxycarbonyl and cyclohexyloxycarbonyl groups; C 6-12 aryloxy-carbonyl groups such as phenyloxycarbonyl and naphthyloxycarbonyl groups; C 6- such as benzyloxycarbonyl groups And 12 aryl C 1-4 alkyloxy-carbonyl group.
- C 1-20 alkoxy-carbonyl groups such as methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, t-butoxycarbonyl,
- acyl group examples include C 1-20 alkyl-carbonyl groups such as formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, pivaloyl, hexanoyl and octanoyl groups; acetoacetyl groups; cyclopentylcarbonyl, cyclohexylcarbonyl groups and the like Examples thereof include alkylcarbonyl groups (C 3-10 cycloalkyl-carbonyl group and the like); aromatic acyl groups such as benzoyl and naphthoyl groups.
- acyloxy group examples include an acyloxy group corresponding to the acyl group, for example, a C 1-20 alkyl-carbonyloxy group; an acetoacetyloxy group; a cycloalkylcarbonyloxy group; an arylcarbonyloxy group.
- the substituents R 1 , R 2 and R 3 may be the same or different.
- a broken line connecting R 1 and R 2 or a broken line connecting R 2 and R 3 is R 1 and R 2 , or R 2 and R 3 , respectively. It shows that it may combine with each other to form an aromatic or non-aromatic ring.
- the ring formed by combining R 1 and R 2 with each other and the ring formed by combining R 2 and R 3 together form a polycyclic aromatic or non-aromatic.
- An aromatic condensed ring may be formed.
- An aromatic or non-aromatic ring formed by combining R 1 and R 2 with each other, and an aromatic or non-aromatic ring formed by combining R 2 and R 3 with each other may be about 5 to 16 members, preferably 6 to 14 members, more preferably 6 to 12 members (for example, 6 to 10 members).
- the aromatic or non-aromatic ring may be a heterocyclic ring or a condensed heterocyclic ring, but the hydrocarbon ring or the hydrocarbon ring is a ring further having 1 or 2 cyclic imino units. There are many.
- Such hydrocarbon rings include, for example, non-aromatic alicyclic rings (C 3-10 cycloalkane rings such as cyclohexane ring, C 3-10 cycloalkene rings such as cyclohexene ring, etc .; non-aromatic bridges) Included are ring rings (bicyclic or tetracyclic bridged hydrocarbon rings such as 5-norbornene ring) and aromatic rings (C 6-12 arene rings such as benzene ring and naphthalene ring, condensed rings, etc.) These rings have substituents (alkyl groups, haloalkyl groups, hydroxyl groups, alkoxy groups, carboxyl groups, substituted oxycarbonyl groups, acyl groups, acyloxy groups, nitro groups, cyano groups, amino groups, halogen atoms, etc.) The ring is often composed of an aromatic ring.
- Preferred catalysts include compounds represented by the following formulas (1a) to (1d) and a compound represented by the above formula (4).
- R 4 to R 16 are the same or different and each represents a hydrogen atom, the exemplified alkyl group, the haloalkyl group, the hydroxyl group, the exemplified alkoxy group, the carboxyl group, the exemplified substituted oxycarbonyl group, the exemplified acyl group, Examples of the acyloxy group, nitro group, cyano group, amino group, and the above-described halogen atom are shown.
- adjacent groups may be bonded to each other to form an aromatic or non-aromatic ring similar to the above, and the following formula (1e)
- -A 3 -is a single bond -A 4 -is a single bond or A cyclic imino unit represented by the formula (A), wherein -A 3- is a single bond when -A 3- is a group represented by the formula (A) It may be formed.
- an aromatic or non-aromatic ring formed by bonding adjacent groups among R 6 to R 12 further includes one or two cyclic imino units represented by the formula (1e). You may have.
- a 2 represents a methylene group or an oxygen atom.
- the double line of a solid line and a broken line shows a single bond or a double bond.
- Examples of the imide compound having a plurality of cyclic imino units include compounds represented by the following formulas.
- R 17 to R 20 are the same or different and each represents a hydrogen atom, the exemplified alkyl group, the haloalkyl group, the hydroxyl group, the exemplified alkoxy group, the carboxyl group, the exemplified substituted oxycarbonyl group, the above exemplified acyl group, the examples of acyloxy group, a nitro group, a cyano group, an amino group, said illustrates an exemplary halogen atom-a.
- the haloalkyl group includes a haloC 1-20 alkyl group such as a trifluoromethyl group.
- the substituents R 4 to R 20 are usually a hydrogen atom, an alkyl group, a carboxyl group, a substituted oxycarbonyl group, a nitro group, or a halogen atom in many cases.
- the imide compound include, for example, compounds in which X is an OH group in the above formula, for example, N-hydroxysuccinimide or N-hydroxysuccinimide at the ⁇ , ⁇ positions (acetoxy, propionyloxy, Valeryloxy, pentanoyloxy, lauroyloxy groups, etc.) and arylcarbonyloxy groups (benzoyloxy groups, etc.) substituted compounds, N-hydroxymaleimide, N-hydroxyhexahydrophthalimide, N, N'-dihydroxycyclohexane
- An alkoxycarbonyl group (methoxycarbonyl, ethoxycarbonyl, pentyloxycarbonyl, dodecyloxycarbonyl) at the 4-position and / or 5-position of tetracarboxylic imide, N-hydroxyphthalimide or N-hydroxyphthalimide Compounds substituted with aryloxycarbonyl group (phenoxycarbonyl group, etc.), N-hydroxytet
- a compound in which X is an OR group R represents a group obtained by removing an OH group from an inorganic acid
- R represents a group obtained by removing an OH group from an inorganic acid
- N-hydride examples thereof include sulfuric acid ester, nitric acid ester, phosphoric acid ester or boric acid ester of roxyphthalic acid imide.
- the method for producing a catalyst (imide compound) having a cyclic imino unit is described in Patent Documents 3 to 5, etc., and can be produced according to the methods described in these documents.
- the acid anhydride corresponding to the catalyst include saturated or unsaturated aliphatic dicarboxylic acid anhydrides such as succinic anhydride and maleic anhydride; tetrahydrophthalic anhydride, hexahydrophthalic anhydride (1,2-cyclohexane).
- Dicarboxylic acid anhydrides 1,2,3,4-cyclohexanetetracarboxylic acid 1,2-anhydrides, saturated or unsaturated non-aromatic cyclic polyvalent carboxylic acid anhydrides (fats, etc.) Cyclic polyvalent carboxylic acid anhydride); bridged cyclic polyvalent carboxylic acid anhydride (alicyclic polyvalent carboxylic acid anhydride) such as het acid anhydride and hymic anhydride; phthalic anhydride, tetrabromophthalic anhydride, Tetrachlorophthalic anhydride, nitrophthalic anhydride, het acid, hymic anhydride, trimellitic anhydride, pyromellitic anhydride, melic anhydride Acid, 1,8; 4,5-naphthalene tetracarboxylic dianhydride, 2,3; and the like 6,7-naphthalene and other aromatic tetracarboxylic dianhydrides polycarboxy
- the catalyst (imide compound) includes a cyclic compound having a skeleton represented by the above formula (1) via a linking group or a linking skeleton (for example, a biphenyl unit, a bisaryl unit, etc.).
- a linking group or a linking skeleton for example, a biphenyl unit, a bisaryl unit, etc.
- Examples of such a catalyst (imide compound) include compounds derived from tetracarboxybiphenyls or acid anhydrides thereof, such as N, N′-dihydroxybiphenyltetracarboxylic imide, N, N′-diacetoxybiphenyltetracarboxylic acid.
- the imide compounds represented by the formula (1) can be used alone or in combination of two or more.
- the imide compound may be generated in the reaction system.
- a preferable catalyst is a water-soluble or water-dispersible imide compound.
- water-soluble or water-dispersible imide compounds include aliphatic dicarboxylic imides, for example, imide compounds corresponding to saturated or unsaturated aliphatic dicarboxylic anhydrides such as succinic anhydride and maleic anhydride (for example, Alkanedicarboxylic imides, alkene carboxylic imides, etc.), and compounds of the above formula (4) (that is, isocyanuric acid having an oxygen atom or —OR group (R is the same as above) on at least one nitrogen atom), etc. included.
- the imide compound may be used in a form supported on a carrier (for example, a porous carrier such as activated carbon, zeolite, silica, silica-alumina, bentonite, etc.), but is usually used without being supported.
- a carrier for example, a porous carrier such as activated carbon, zeolite, silica, silica-alumina, bentonite, etc.
- the amount of the imide compound supported relative to 100 parts by weight of the carrier is, for example, about 0.1 to 50 parts by weight, preferably about 0.5 to 30 parts by weight, and more preferably about 1 to 20 parts by weight. It is.
- transition metal promoter Regarding the transition metal promoter, the above-mentioned patent documents 3 to 5 can be referred to.
- the transition metal promoter a metal compound having a metal element of Groups 2 to 15 of the periodic table is often used. In this specification, boron B is also included in the metal element.
- the metal element examples include Group 2 elements (Mg, Ca, Sr, Ba, etc.), Group 3 elements (Sc, lanthanoid elements, actinoid elements, etc.), Group 4 elements (Ti, Zr, Hf, etc.), Group 5 Element (such as V), group 6 element (such as Cr, Mo, W), group 7 element (such as Mn), group 8 element (such as Fe, Ru, Os), group 9 element (such as Co, Rh, Ir), Group 10 elements (Ni, Pd, Pt, etc.), Group 11 elements (Cu, etc.), Group 12 elements (Zn, etc.), Group 13 elements (B, Al, In, etc.), Group 14 elements (Sn, Pb, etc.), Examples include Group 15 elements (Sb, Bi, etc.).
- transition metal elements Group 3-12 elements of the periodic table
- Mn, Co, Zr, Ce, Fe, V, Mo, etc. especially Mn, Co, Zr, Ce, Fe
- the valence of the metal element is not particularly limited, and is about 0 to 6, for example.
- the metal compound examples include simple substances, hydroxides, oxides (including composite oxides), halides (fluorides, chlorides, bromides, iodides), oxo acid salts (eg, nitrates, sulfates) of the above metal elements. , Phosphates, borates, carbonates, etc.), inorganic compounds such as isopolyacid salts, heteropolyacid salts; organic acid salts (eg acetate, propionate, cyanate, naphthenate, stearic acid) Salt) and organic compounds such as complexes.
- inorganic compounds such as isopolyacid salts, heteropolyacid salts; organic acid salts (eg acetate, propionate, cyanate, naphthenate, stearic acid) Salt) and organic compounds such as complexes.
- the ligand of the complex includes OH (hydroxo), alkoxy (methoxy, ethoxy, propoxy, butoxy, etc.), acyl (acetyl, propionyl, etc.), alkoxycarbonyl (methoxycarbonyl, ethoxycarbonyl, etc.), acetylacetonato, cyclo Pentadienyl group, halogen atom (chlorine, bromine, etc.), CO, CN, oxygen atom, H 2 O (aco), phosphine (triarylphosphine such as triphenylphosphine), phosphorus compound, NH 3 (ammine), Examples thereof include nitrogen-containing compounds such as NO, NO 2 (nitro), NO 3 (nitrato), ethylenediamine, diethylenetriamine, pyridine, and phenanthroline.
- nitrogen-containing compounds such as NO, NO 2 (nitro), NO 3 (nitrato), ethylenediamine, diethylenetriamine, pyridine,
- metal compounds include hydroxides [cobalt hydroxide, vanadium hydroxide, etc.], oxides [cobalt oxide, vanadium oxide, manganese oxide, zirconium oxide, etc.], halides (cobalt chloride, cobalt bromide, etc.).
- Inorganic compounds such as inorganic acid salts (cobalt nitrate, cobalt sulfate, cobalt phosphate, vanadium sulfate, vanadyl sulfate, sodium vanadate, manganese sulfate, zirconium sulfate, etc.); organic acids Salts [cobalt acetate, cobalt naphthenate, cobalt stearate, manganese acetate, zirconium acetate, zirconium oxoacetate, etc.]; complexes [divalent or trivalent cobalt compounds such as cobalt acetylacetonate, vanadium acetylacetonate, vanadyl acetylacetate] 2-5 valent vanadium compounds such as diisocyanato, divalent or trivalent manganese compound, manganese acetylacetonate, tetravalent or pentavalent zirconium compounds such as zircon
- Metal compounds can be used alone or in combination of two or more. A plurality of metal compounds having different valences may be used in combination.
- the transition metal promoter preferably includes at least a Group 9 metal component (such as a cobalt compound) and a Group 7 metal component (such as a manganese compound) of the periodic table. When such a combination is used, the catalytic activity of the imide compound can be increased.
- a Group 9 metal component such as a cobalt compound
- a Group 7 metal component such as a manganese compound
- each metal component can be used in an appropriate quantitative ratio as long as the catalytic activity is not inhibited.
- the periodic table 9 group metal component (cobalt compound) and the periodic table 7 group metal component (manganese compound) are used in combination, for example, in the periodic table 9 group metal component 1 mol in terms of metal element, for example, the periodic table It may be about 0.1 to 5 mol, preferably 0.5 to 2 mol, more preferably about 0.7 to 1.5 mol (for example, 0.8 to 1.2 mol) of the Group 7 metal component.
- transition metal promoter may be capable of forming a salt with an aromatic carboxylic acid (for example, dicarboxylic acid, monocarboxylic acid, etc.) generated by an oxidation reaction.
- aromatic carboxylic acid for example, dicarboxylic acid, monocarboxylic acid, etc.
- a polyatomic cation or polyatomic anion containing a group 15 element (N, P, As, Sb, etc.) or a group 16 element (S, etc.) to which at least one organic group is bonded as a promoter It is also possible to use an organic salt composed of and counter ions.
- the organic salt include organic onium salts such as organic ammonium salts, organic phosphonium salts, and organic sulfonium salts.
- organic salts examples include alkyl sulfonates; aryl sulfonates optionally substituted with a C 1-20 alkyl group; sulfonic acid type ion exchange resins (ion exchangers); phosphonic acid type ion exchange resins (ion exchanges) Body).
- the amount of the organic salt used is, for example, about 0.001 to 10 mol, preferably 0.005 to 5 mol, more preferably about 0.01 to 3 mol, per 1 mol of the imide compound.
- a strong acid such as hydrogen halide, hydrohalic acid, sulfuric acid, heteropoly acid and the like may be used as a cocatalyst.
- the amount of strong acid used is, for example, about 0.001 to 3 mol, preferably about 0.005 to 2.5 mol, and more preferably about 0.01 to 2 mol, with respect to 1 mol of the imide compound.
- a carbonyl compound having an electron withdrawing group such as hexafluoroacetone, trifluoroacetic acid, pentafluorophenyl ketone, benzoic acid, etc.
- the amount of the carbonyl compound to be used is about 0.0001 to 3 mol, preferably 0.0005 to 2.5 mol, more preferably about 0.001 to 2 mol, per 1 mol of the reaction component (substrate).
- a radical generator or a radical reaction accelerator may be present in the system.
- such components include hydrous such as halogen (chlorine, bromine, etc.), peracid (peracetic acid, m-chloroperbenzoic acid, etc.), peroxide (hydrogen peroxide, t-butyl hydroperoxide (TBHP), etc. Peroxide), nitric acid or nitrous acid or salts thereof, nitrogen dioxide, aldehydes such as benzaldehyde (for example, aldehydes corresponding to the aromatic polycarboxylic acid which is the target compound) and the like.
- the amount of the component used is about 0.001 to 1 mole, preferably about 0.005 to 0.8 mole, and more preferably about 0.01 to 0.5 mole relative to 1 mole of the imide compound.
- an aromatic compound having an alkyl group and / or an alkylene group an aromatic compound in which an alkyl group or an alkylene group (or an alkylidene group) is usually bonded to an aromatic ring (or aromatic ring) can be used.
- Aromatic hydrocarbons or heterocycles in which an alkyl group or alkylene group (or alkylidene group) is bonded to an aromatic ring are at least one alkyl group or alkylene group And may have a plurality of alkyl groups or alkylene groups.
- “low-order oxidized groups” of alkyl groups or alkylene groups that are generated by oxidation of these groups and do not lead to final carboxyl groups or equivalents thereof (such as acid anhydride groups). May be included.
- the oxidation site of such a substrate includes the low-order oxidation group in addition to the alkyl group or the alkylene group.
- aromatic hydrocarbon ring examples include monocyclic or condensed polycyclic hydrocarbon rings corresponding to, for example, benzene, naphthalene, acenaphthylene, phenanthrene, anthracene, and pyrene; Hydrocarbon rings corresponding to, for example, biphenyl, terphenyl, binaphthyl, etc .; aromatic hydrocarbon rings are linked through a divalent group such as oxygen atom, sulfur atom, sulfide group, carbonyl group, alkylene group, cycloalkylene group Examples thereof include bisarenes corresponding to biphenyl ether, biphenyl sulfide, biphenyl sulfone, biphenyl ketone, biphenyl alkane and the like.
- an aromatic heterocycle having about 1 to 3 heteroatoms selected from an oxygen atom, a sulfur atom and a nitrogen atom, for example, a thiophene ring, a pyrrole ring, an imidazole ring Oxazole ring, thiazole ring, pyridine ring, pyridazine ring, pyrimidine ring, pyrazine ring, quinoline ring, indole ring, indazole ring, benzotriazole ring, quinazoline ring, acridine ring, chromone ring and the like.
- aromatic rings may have a substituent (for example, carboxyl group, halogen atom, hydroxyl group, alkoxy group, acyloxy group, substituted oxycarbonyl group, substituted or unsubstituted amino group, nitro group, etc.). Good.
- the aromatic ring may be condensed with a non-aromatic ring.
- alkyl group bonded to the aromatic ring examples include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, s-butyl, pentyl, isopentyl, hexyl, isohexyl, heptyl, octyl, 2-ethylhexyl, decyl group and the like.
- primary or secondary C 1-10 alkyl groups are C 1-4 alkyl groups, especially C 1-3 alkyl groups such as methyl, ethyl and isopropyl groups.
- Examples of the lower oxidation group of the alkyl group include, for example, a hydroxyalkyl group (for example, a hydroxy C 1-3 alkyl group such as hydroxymethyl and 1-hydroxyethyl), a formyl group, a formylalkyl group (for example, formylmethyl, 1-hydroxyethyl).
- a hydroxyalkyl group for example, a hydroxy C 1-3 alkyl group such as hydroxymethyl and 1-hydroxyethyl
- a formyl group for example, a formylalkyl group (for example, formylmethyl, 1-hydroxyethyl).
- Formyl C 1-3 alkyl group such as formylethyl group
- alkyl groups having an oxo group for example, C 1-4 acyl group such as acetyl, propionyl, butyryl group
- Preferred alkylene groups are C 1-4 alkylene groups, particularly methylene groups, as well as C 2-4 alkylene groups such as ethylene and propylene groups, especially methylene groups.
- Examples of the lower oxidation group of the alkylene group include a hydroxyalkylene group (for example, a hydroxy C 1-3 alkylene group such as hydroxymethylene and 1-hydroxyethylene), a carbonyl group, and an alkylene group having an oxo group (for example, —CH Oxo-C 1-4 alkanediyl groups such as 2- C ( ⁇ O) —, —CH 2 —C ( ⁇ O) —CH 2 — group, and the like.
- a hydroxyalkylene group for example, a hydroxy C 1-3 alkylene group such as hydroxymethylene and 1-hydroxyethylene
- a carbonyl group and an alkylene group having an oxo group (for example, —CH Oxo-C 1-4 alkanediyl groups such as 2- C ( ⁇ O) —, —CH 2 —C ( ⁇ O) —CH 2 — group, and the like.
- the said alkyl group, alkylene group, or these low-order oxidation groups may have a substituent in the range which does not inhibit reaction.
- the aromatic compound of the substrate includes an alkyl group, an alkylene group, or a lower oxidation group thereof, a carboxyl group and / or an alkoxycarbonyl group (a lower alkoxycarbonyl group such as a methoxycarbonyl group or an ethoxycarbonyl group (for example, C 1 -4 alkoxy-carbonyl group, etc.).
- the aromatic ring has 1 to 10, preferably 1 to 6, more preferably 1 to 4 alkyl groups, alkylene groups, or lower-order oxidation groups thereof, depending on the number of members of the ring. You may have a degree. Incidentally, the number of alkylene groups or lower-order oxidation groups thereof is usually about 1 to 3.
- the aromatic ring preferably has one or two alkyl groups, alkylene groups, or lower-order oxidation groups thereof.
- the aromatic compound having an alkyl group usually has an alkyl group having a carbon number corresponding to the target aromatic carboxylic acid.
- aromatic compound having an alkyl group examples include toluene, ethylbenzene, propylbenzene, xylene (such as o-, m- or p-xylene), t-butyltoluene (o-, m- or pt-butyltoluene).
- aromatic compound having an alkylene group or a lower oxidation group thereof examples include, for example, dibenzyl, diphenylmethane, benzophenone and the like, an aromatic heterocyclic ring, and an alkylene group (methylene group) adjacent to the aromatic heterocyclic ring.
- aromatic heterocyclic compound having a group and the like examples include, for example, dibenzyl, diphenylmethane, benzophenone and the like, an aromatic heterocyclic ring, and an alkylene group (methylene group) adjacent to the aromatic heterocyclic ring.
- Preferred aromatic compounds include aromatic compounds in which one or two C 1-4 alkyl groups and / or C 1-4 alkylene groups are substituted on an aromatic ring (aromatic ring, for example, aromatic hydrocarbon ring). It is.
- C 6-10 arenes having a C 1-4 alkyl group such as toluene and ethylbenzene (especially alkyl benzene);
- C 6-10 arenes having a C 1-4 alkyl group such as methyl toluate, C 1 of carboxylic acid -4 alkyl esters are preferred.
- the substrate includes various substituents (halogen atom, alkyl group, alkenyl group, aryl group, heterocyclic group, oxo group, hydroxyl group, alkoxy group, hydroxyalkyl group, carboxyl group, alkoxycarbonyl group, acyl group.
- substituents halogen atom, alkyl group, alkenyl group, aryl group, heterocyclic group, oxo group, hydroxyl group, alkoxy group, hydroxyalkyl group, carboxyl group, alkoxycarbonyl group, acyl group.
- a substrate having an amino group, a substituted amino group, a cyano group, a nitro group, or the like) may be used.
- oxygen As the oxygen to be contacted with the substrate, either molecular oxygen or nascent oxygen can be used.
- the molecular oxygen is not particularly limited, and pure oxygen may be used, or oxygen, air, or diluted air diluted with an inert gas such as nitrogen, helium, argon, or carbon dioxide may be used. Further, oxygen may be generated in the system.
- the amount of oxygen used is usually 0.5 mol or more (for example, 1 mol or more), preferably 1 to 10000 mol, more preferably about 5 to 1000 mol, relative to 1 mol of the substrate. Often an excess of oxygen is used relative to the substrate.
- an acid anhydride In addition, you may add an acid anhydride to a reaction system as needed.
- the acid anhydride include aliphatic monocarboxylic anhydrides such as acetic anhydride, propionic anhydride, butyric anhydride, and isobutyric anhydride; aromatic monocarboxylic anhydrides such as benzoic anhydride; Acid anhydrides (aliphatic polycarboxylic anhydrides, alicyclic polycarboxylic anhydrides, aromatic polycarboxylic anhydrides) and the like. Of these acid anhydrides, aliphatic monocarboxylic acid anhydrides, particularly acetic anhydride, are preferred.
- the amount of acid anhydride to be used may be, for example, about 0.1 to 100 mol, preferably 0.5 to 40 mol, more preferably about 1 to 20 mol, relative to 1 mol of the substrate.
- the acid anhydride can be used in a large excess with respect to the substrate.
- the above-mentioned substrate that is, an aromatic compound having an alkyl group and / or an alkylene group is oxidized with oxygen, whereby the alkyl group and / or the alkylene group are oxidized with oxygen, and the oxide corresponding to the substrate is obtained.
- hydroxy compounds such as alkanol having an aromatic ring such as benzyl alcohol (such as C 6-10 aryl C 1-4 alkanol)
- aldehyde compounds such as aromatic aldehyde, alkanal having an aromatic ring
- Ketone compounds aryl-alkyl-ketones such as acetophenone; aralkyl-alkyl-ketones and the like
- organic acids such as aromatic carboxylic acids
- Oxidation of a hydroxy compound produces a corresponding aldehyde compound, ketone compound, organic acid, etc., and formation of a corresponding organic acid by oxidation of the aldehyde compound. Furthermore, ketones are cleaved by oxidation to produce corresponding aldehyde (formyl) compounds and organic acids. And finally, the aromatic carboxylic acid which is a target compound is obtained. Therefore, the hydroxy compound, aldehyde compound, and ketone compound corresponding to the substrate may be referred to as a reaction intermediate in the oxidation reaction system.
- benzoic acid is obtained by oxidation of toluene
- acetophenone and benzoic acid are obtained by oxidation of ethylbenzene
- oxidation of xylene produces toluic acid in which one methyl group is oxidized and phthalic acid (or isophthalic acid or terephthalic acid) in which two methyl groups are oxidized together.
- phthalic acid or isophthalic acid or terephthalic acid
- methyl group is oxidized
- monomethyl phthalate or monomethyl isophthalate or terephthalic acid in which the methyl group is oxidized.
- Monomethyl is formed.
- the final reaction product includes water produced by the reaction in addition to an organic acid (such as aromatic carboxylic acid) obtained by oxidation of the substrate. This water is not included in the reaction solvent in the method of the present invention.
- an organic acid such as aromatic carboxylic acid
- generated by the oxidation of the alkyl group or the alkylene group may be further decarboxylated in the oxidation reaction system.
- a decarboxylation reaction pathway for example, benzoic acid is obtained by oxidation of xylene, and methyl benzoate is generated by oxidation of methyl toluate.
- the yield of the target organic acid for example, aromatic carboxylic acids such as xylene and phthalic acids which are oxidation products of methyl toluate
- generation of the decarboxylation which is a by-product can be reduced significantly.
- a substrate a reaction intermediate and / or a reaction product [specifically, (b-1) an aromatic compound having an alkyl group and / or an alkylene group as a substrate, (b -2) Select from carbonyl compounds corresponding to this aromatic compound (for example, reaction intermediates such as ketones and aldehydes; reaction products such as aromatic carboxylic acids), and (b-3) water generated by oxidation reaction Since the oxidation reaction is carried out while sequentially or continuously supplying the at least one kind etc.] to the oxidation reaction system, the reaction rate can be improved and the aromatic carboxylic acid can be produced efficiently.
- (b-1) an aromatic compound having an alkyl group and / or an alkylene group as a substrate
- b -2 Select from carbonyl compounds corresponding to this aromatic compound (for example, reaction intermediates such as ketones and aldehydes; reaction products such as aromatic carboxylic acids), and (b-3) water generated by oxidation reaction Since the oxidation reaction is carried out while sequentially or continuously
- the generated aromatic carboxylic acid forms a salt with the transition metal promoter, and this salt can act as an active species, so that the reaction efficiency can be further increased. Therefore, the reaction can proceed efficiently even with a small amount of catalyst, which is advantageous in terms of energy and cost.
- a reaction solvent a reaction solvent different from the substrate, reaction intermediate, and reaction product
- loss of product and complicated work in the purification process can be reduced.
- the reaction intermediate and / or reaction product supplied to the reaction system together with the imide catalyst may be a reaction intermediate and / or reaction product actually produced in the reaction system, but usually prepared separately. In many cases, a compound corresponding to the reaction intermediate (the same compound as the reaction intermediate) and a compound corresponding to the reaction product (the same compound as the reaction product) are used.
- the amount of the catalyst (imide compound) used can be selected in a wide range of about 0.0001 to 100 mol% in terms of cyclic imino units with respect to the reaction component (substrate; aromatic compound).
- the amount may be 0.0005 to 50 mol%, preferably 0.001 to 30 mol%, more preferably about 0.005 to 10 mol%, based on the substrate.
- reaction efficiency can be improved significantly, even if there is little usage-amount of an imide compound, reaction can be advanced efficiently.
- the amount of the imide compound used may be, for example, about 0.0002 to 5 mol%, preferably about 0.0007 to 1 mol%, more preferably about 0.001 to 0.5 mol% relative to the substrate. Good.
- the catalyst may be added to the reaction system so as to have a concentration of about 1 to 100,000 ppm, preferably about 5 to 10,000 ppm, more preferably about 10 to 5,000 ppm with respect to the reaction mixture.
- the ratio of the imide compound can be selected from the range of about 0.001 to 1000 mol, preferably 0.05 to 100 mol, and more preferably 0.001 mol per 1 mol of the transition metal promoter (in terms of metal element). It may be about 1 to 10 mol (for example, 0.5 to 5 mol).
- the proportion of the catalyst may be the same as or less than that of the transition metal promoter.
- the ratio of the catalyst is, for example, 0.01 to 1.1 mol, preferably 0.02 to 1 mol, more preferably 0.03 to 0.9 mol, with respect to 1 mol of the transition metal promoter (in terms of metal element). It may be about a mole.
- the components added to the reaction system together with the catalyst include a substrate (aromatic compound having an alkyl group and / or an alkylene group), a reaction intermediate (hydroxy compound corresponding to the aromatic compound, ketone, aldehyde (especially ketone, Aldehyde) and the like, and reaction products (water; organic acids such as aromatic carboxylic acids).
- a substrate aromatic compound having an alkyl group and / or an alkylene group
- a reaction intermediate hydroxy compound corresponding to the aromatic compound, ketone, aldehyde (especially ketone, Aldehyde) and the like
- reaction products water; organic acids such as aromatic carboxylic acids
- the mixture may be in any form such as a solution, a dispersion, a slurry.
- the ratio of the above components supplied to the reaction system together with the catalyst with respect to 1 part by weight of the catalyst is, for example, 1 to 1 ⁇ 10 6 parts by weight, preferably 1.5 to 1 ⁇ 10 5 parts by weight, and more preferably 2 parts. It may be about 1 ⁇ 10 3 parts by weight, particularly about 3 to 300 parts by weight.
- solvents include halogenated hydrocarbons such as dichloromethane, chloroform, 1,2-dichloroethane and dichlorobenzene; aliphatic alcohols such as methanol, ethanol, t-butanol and t-amyl alcohol; nitriles such as acetonitrile and benzonitrile Aliphatic carboxylic acids such as formic acid, acetic acid, propionic acid, butyric acid, isobutyric acid and hexanoic acid; Esters of aliphatic carboxylic acids such as ethyl acetate; Amides such as formamide, acetamide, dimethylformamide (DMF) and dimethylacetamide Such solvents may be used as a mixture.
- halogenated hydrocarbons such as dichloromethane, chloroform, 1,2-dichloroethane and dichlorobenzene
- aliphatic alcohols such as methanol, ethanol, t-butanol and
- a solvent it is preferable not to use a solvent.
- a water-soluble organic solvent such as C 1-3 alkanol such as methanol and ethanol; aliphatic nitrile such as acetonitrile; aliphatic C 2-4 such as acetic acid. Carboxylic acid and the like are preferable.
- the proportion of the solvent is 80% by weight or less (for example, 0 to 50% by weight), preferably 0 to 30% by weight (for example, 0 to 10% by weight), more preferably, based on the above-mentioned components supplied together with the catalyst. It is about 0 to 5% by weight (for example, 0 to 2% by weight).
- the above mixture containing the catalyst is supplied sequentially (intermittently) or continuously to the oxidation reaction system.
- the supply time of the catalyst (that is, the time required from the start of addition of the catalyst to the end of the addition) can be appropriately selected. For example, it is 1 to 10 hours, preferably 1.5 to 7 hours, and more preferably about 2 to 6 hours. There may be.
- the method of the present invention can also be applied to a continuous process.
- components other than the catalyst for example, transition metal promoter, other promoter, substrate and other components (components added to the reaction system) may be charged in advance in the reactor or in the initial stage of the reaction. Alternatively, any of the components may be charged in advance at the beginning of the reaction and the other components may be added sequentially or continuously.
- oxygen can be introduced into the reaction system in various modes such as continuous supply, sequential supply, and batch supply, but it is preferable to supply oxygen continuously to the reaction system.
- the off-gas oxygen concentration from the reaction system is not particularly limited and is, for example, about 0 to 8% by volume, preferably about 0.1 to 7% by volume, and more preferably about 1 to 6% by volume.
- a reaction intermediate (the hydroxy compound, ketone, aldehyde, etc.) and / or a reaction product (aromatic carboxylic acid, etc.) may be added in advance.
- an aromatic compound having an alkyl group and / or alkylene group such as methyl toluate as a substrate and a carboxyl group protected by a protective group (such as an alkyl group) such as an alkoxycarbonyl group is used, this aromatic group is used.
- An aromatic compound corresponding to the compound and having a free carboxyl group (an aromatic compound having an alkyl group and / or alkylene group such as toluic acid and a carboxyl group (that is, an aromatic group having an alkyl group and / or an alkylene group)
- the group carboxylic acid may be added to the reaction system in advance.
- an aromatic carboxylic acid (the same aromatic carboxylic acid and / or an aromatic carboxylic acid having an alkyl group and / or an alkylene group as the reaction product) is added in advance. Is preferred.
- the proportion of these components is, for example, 0.001 to 15 mol%, preferably 0.01 to 10 mol%, more preferably 0.1 to 7 mol% (particularly 1 to 5 mol%) relative to the substrate. ) Degree.
- the reaction rate can be greatly improved.
- the aromatic carboxylic acid may be added at the beginning of the reaction, or may be generated in the reaction system during the oxidation reaction.
- the oxidation reaction may be performed in the presence of a small amount of a reaction solvent (for example, the solvent exemplified above), but it is usually preferable to perform the oxidation reaction in the absence of the reaction solvent.
- a reaction solvent for example, the solvent exemplified above
- the amount of the reaction solvent used is, for example, 25% by weight or less (for example, 0 to 20% by weight), preferably 0 to 10% by weight, more preferably 0 to 5% by weight (for example, 0 to 2% by weight).
- the reaction may be performed while removing this water from the reaction system (for example, by removing by distillation or the like).
- the amount of removal is not particularly limited, but it is preferable to remove water at least to the extent that the reaction solution does not separate.
- the removal of water may be performed by, for example, reactive distillation performed while removing water, a water separator such as a decanter may be used, or a reaction that removes water in combination with a water separator such as a decanter. You may carry out by distillation.
- the reaction is carried out while removing water, the oxidation reaction can be promoted and the formation of by-products can be suppressed, and target reaction products such as aromatic carboxylic acids (aromatic dicarboxylic acids, aromatic monocarboxylic acids, etc.) Can be obtained in high yield.
- the temperature of the oxidation reaction may be, for example, about 10 to 300 ° C., preferably about 25 to 250 ° C., more preferably about 50 to 200 ° C., depending on the type of reactant and substrate.
- the reaction may be performed at a substantially constant temperature, may be performed in a plurality of temperature ranges as necessary, and may be performed while raising or lowering temperature stepwise or continuously.
- the reaction may be carried out under reduced pressure, but since the solubility of oxygen is higher under pressurized conditions, it is usually carried out under normal pressure or pressurized pressure.
- the reaction pressure may be, for example, about 0.1 to 10 MPa, preferably 0.12 to 5 MPa, more preferably about 0.15 to 2 MPa (particularly 0.2 to 1 MPa).
- the reaction operation may be performed in a continuous, batch, or semi-batch manner.
- the reaction product can be separated and purified by separation means such as filtration, concentration, distillation, extraction, crystallization, recrystallization, adsorption, column chromatography, etc., or a separation means combining these.
- Aromatic carboxylic acids obtained in the present invention are used in a wide range of fields such as heat-resistant polymers (polyimide polymers, polyester polymers, etc.), main raw materials such as heat-resistant plasticizers, and heat-resistant epoxy resin curing agents. (For example, in the field of electronic materials).
- Example 1 In an air-flowing pressurized reactor equipped with a dehydration device similar to Dean Stark, 300 g (2.8 mol) of p-xylene, 0.20 g (1.1 mmol) of cobalt acetate (divalent) and manganese acetate (2 (Valence) 0.20 g (1.2 mmol) was added, nitrogen was introduced and the pressure was increased to 0.5 MPa. Subsequently, it heated at 150 degreeC and the gas which mixed air and nitrogen was distribute
- reaction start time The time when the addition of the catalyst was started was taken as the reaction start time, and the time when the catalyst addition was finished was taken as the reaction end time.
- the reaction was carried out while trapping water. After completion of the reaction, the reactor was cooled and opened, and the conversion of the substrate, the yield of the product and the yield were calculated by high performance liquid chromatography (HPLC) analysis of the reaction mixture. Conversion rate of p-xylene was 35.7%, p-toluic acid 110 g (yield 28.9%), terephthalic acid 31 g (yield 6.68%), by-product benzoic acid 0.32 g (yield) 0.094%) was obtained.
- Comparative Example 1 The reaction was carried out in the same manner as in Example 1 except that 2 g of water was used instead of the mixed solution of N-hydroxysuccinimide and water, and the substrate conversion rate and the product yield / yield were calculated. The time when the addition of water was started was taken as the reaction start time, and the time when the addition of water was finished was taken as the reaction end time. As a result of the reaction, the conversion rate of p-xylene was 1.68%, p-toluic acid 5 g (yield 1.31%), terephthalic acid 1 g (yield 0.22%), and by-product benzoic acid 0 0.03 g (yield 0.0088%) was obtained.
- Example 2 The reaction was carried out in the same manner as in Example 1 except that 0.025 g (0.141 mmol) of trihydroxyisocyanuric acid was used instead of N-hydroxysuccinimide, and the substrate conversion rate and the yield and yield of the product were determined. Calculated. As a result, the conversion of p-xylene was 36.4%, 113 g of p-toluic acid (yield 29.7%), 21 g of terephthalic acid (yield 4.52%), and 0.30 g of by-product benzoic acid. (Yield 0.0878%) was obtained.
- Example 3 In addition to 300 g (2.8 mol) of p-xylene, 10 g (73.5 mmol) of p-toluic acid was used, and the amounts of manganese acetate (divalent) and N-hydroxysuccinimide were 0.10 g and 0.005%, respectively.
- the reaction was carried out in the same manner as in Example 1 except that the amount was changed to 17 g, and the substrate conversion rate and the product yield were calculated.
- the conversion rate of p-xylene was 48.9%, and the yields of the product were 150 g of p-toluic acid, 44 g of terephthalic acid, and 0.40 g of by-product benzoic acid, respectively.
- Comparative Example 2 The reaction was carried out in the same manner as in Example 3 except that 2 g of water was used instead of the mixed solution of N-hydroxysuccinimide and water, and the substrate conversion rate and the product yield were calculated. The time when the addition of water was started was taken as the reaction start time, and the time when the addition of water was finished was taken as the reaction end time. As a result, the conversion rate of p-xylene was 32.7%, and the yields of the products were 90 g of p-toluic acid, 32 g of terephthalic acid, and 0.52 g of by-product benzoic acid, respectively.
- Example 4 The reaction was carried out in the same manner as in Example 3 except that 300 g (2.0 mol) of methyl p-toluate was used in place of 300 g of p-xylene and the pressure of the reaction system was increased to 0.2 MPa. The conversion and product yield were calculated. As a result, the conversion rate of methyl p-toluate was 30%, and the yields of the product were 110 g of monomethyl terephthalate, 3.5 g of terephthalic acid, and 1 g of methyl benzoate as a by-product, respectively. In the reaction solution, 7 g of p-toluic acid used together with the substrate methyl p-toluate remained.
- Comparative Example 3 The reaction was carried out in the same manner as in Example 4 except that 2 g of water was used instead of the mixed solution of N-hydroxysuccinimide and water, and the substrate conversion rate and the product yield were calculated. The time when the addition of water was started was taken as the reaction start time, and the time when the addition of water was finished was taken as the reaction end time. As a result of the reaction, the conversion rate of methyl p-toluate was 16%, and the yields of the product were 53 g of monomethyl terephthalate, 2 g of terephthalic acid, and 1.2 g of methyl benzoate as a by-product, respectively. In the reaction solution, 8 g of p-toluic acid used together with the substrate methyl p-toluate remained.
- Example 5 Instead of a mixed solution of N-hydroxysuccinimide and water, a mixed solution of 0.17 g of N-hydroxysuccinimide and 10 g of methyl p-toluate was used, and this mixed solution was slurried in a reactor for 5 hours.
- the reaction was carried out in the same manner as in Example 4 except that continuous feed was performed with a pump, and the substrate conversion rate and the product yield were calculated.
- the conversion rate of methyl p-toluate was 28.3%
- the yields of the products were 115 g of monomethyl terephthalate, 3.5 g of terephthalic acid, and 1.0 g of methyl benzoate as a by-product, respectively. there were.
- 6 g of p-toluic acid used together with the substrate methyl p-toluate remained.
- Example 6 The same as Example 5 except that a mixed solution of 0.017 g of N-hydroxysuccinimide and 10 g of methyl p-toluate was used instead of the mixed solution of 0.17 g of N-hydroxysuccinimide and 10 g of methyl p-toluate.
- the reaction was performed and the substrate conversion and product yield were calculated.
- the conversion rate of methyl p-toluate was 22.3%
- the yield of the product was 88 g of monomethyl terephthalate, 3.5 g of terephthalic acid, and 1.0 g of methyl benzoate as a by-product, respectively. there were.
- 7 g of p-toluic acid used together with the substrate methyl p-toluate remained.
- Example 7 In place of 300 g (2.0 mol) of methyl p-toluate and 10 g of p-toluic acid, 300 g (2.8 mol) of ethylbenzene was used, and the pressure of the reaction system was increased to 0.4 MPa, so that N-hydroxysuccinimide In the same manner as in Example 6, except that a mixed solution of 0.017 g of N-hydroxysuccinimide and 10 g of acetophenone was continuously fed over 1 hour instead of a mixed solution of 0.017 g and 10 g of methyl p-toluate. The reaction was performed and the substrate conversion and product yield were calculated. As a result, the conversion of ethylbenzene was 27.0%, and the yield of the product was 32 g of acetophenone and 64 g of benzoic acid, respectively.
- Comparative Example 4 The reaction was carried out in the same manner as in Example 7 except that 10 g of acetophenone was continuously fed instead of the mixed solution of 0.017 g of N-hydroxysuccinimide and 10 g of acetophenone, and the substrate conversion rate and the product yield were calculated. .
- the time when the addition of acetophenone was started was taken as the reaction start time, and the time when the addition of acetophenone was finished was taken as the reaction end time.
- the conversion of ethylbenzene was 6.74%
- the yields of the products were 16 g of acetophenone and 16 g of benzoic acid, respectively.
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Abstract
Description
イミド化合物は、環の構成要素として前記式(1)で表される骨格(骨格(1))を有する環状イミノ単位を有する化合物である。イミド化合物は、分子中に、少なくとも1つの骨格(1)を有していればよく、複数の骨格(1)を有していてもよい。また、環状イミノ単位は、構成要素として複数の骨格(1)で1つの環を構成していてもよい。環状イミノ単位は、骨格(1)が有する窒素原子以外に、1つ又は複数のヘテロ原子(例えば、窒素原子、硫黄原子、酸素原子など(特に窒素原子))を環の構成原子として有していてもよい。
置換基R1、R2及びR3で表されるハロゲン原子には、ヨウ素、臭素、塩素およびフッ素原子が含まれる。アルキル基には、例えば、メチル、エチル、プロピル、イソプロピル、ブチル、イソブチル、s-ブチル、t-ブチル、ヘキシル、デシル基などの直鎖状又は分岐鎖状C1-20アルキル基(特にC1-16アルキル基)が含まれる。シクロアルキル基には、シクロペンチル、シクロヘキシル基などのC3-10シクロアルキル基が含まれる。アリール基には、フェニル、ナフチル基などが含まれる。
なお、複数の環状イミノ単位を有するイミド化合物としては、例えば、下記式で表される化合物などが例示できる。
置換基R4~R20において、ハロアルキル基には、トリフルオロメチル基などのハロC1-20アルキル基が含まれる。置換基R4~R20は、通常、水素原子、アルキル基、カルボキシル基、置換オキシカルボニル基、ニトロ基、ハロゲン原子である場合が多い。
遷移金属助触媒についても、前記特許文献3~5などを参照できる。遷移金属助触媒としては、周期表2~15族の金属元素を有する金属化合物を用いる場合が多い。なお、本明細書では、ホウ素Bも金属元素に含まれるものとする。前記金属元素としては、周期表2族元素(Mg、Ca、Sr、Baなど)、3族元素(Sc、ランタノイド元素、アクチノイド元素など)、4族元素(Ti、Zr、Hfなど)、5族元素(Vなど)、6族元素(Cr、Mo、Wなど)、7族元素(Mnなど)、8族元素(Fe、Ru、Osなど)、9族元素(Co、Rh、Irなど)、10族元素(Ni、Pd、Ptなど)、11族元素(Cuなど)、12族元素(Znなど)、13族元素(B、Al、Inなど)、14族元素(Sn、Pbなど)、15族元素(Sb、Biなど)などが挙げられる。これらの金属元素のうち、遷移金属元素(周期表3~12族元素)、特に、Mn、Co、Zr、Ce、Fe、V、Moなど(とりわけ、Mn、Co、Zr、Ce、Fe)が好ましい。金属元素の原子価は特に制限されず、例えば0~6価程度である。
本発明では、助触媒として、少なくとも1つの有機基が結合した周期表15族元素(N、P、As、Sbなど)又は16族元素(Sなど)を含む多原子陽イオン又は多原子陰イオンとカウンターイオンとで構成された有機塩を用いることもできる。前記有機塩の代表的な例として、有機アンモニウム塩、有機ホスホニウム塩、有機スルホニウム塩などの有機オニウム塩が挙げられる。前記有機塩には、アルキルスルホン酸塩;C1-20アルキル基で置換されていてもよいアリールスルホン酸塩;スルホン酸型イオン交換樹脂(イオン交換体);ホスホン酸型イオン交換樹脂(イオン交換体)なども含まれる。有機塩の使用量は、例えば、前記イミド化合物1モルに対して、0.001~10モル程度、好ましくは0.005~5モル、さらに好ましくは0.01~3モル程度である。
アルキル基及び/又はアルキレン基を有する芳香族化合物としては、通常、芳香族性環(又は芳香環)にアルキル基又はアルキレン基(又はアルキリデン基)が結合した芳香族化合物が使用できる。
基質と接触させる酸素としては、分子状酸素及び発生期の酸素のいずれでも使用できる。分子状酸素は特に制限されず、純粋な酸素を用いてもよく、窒素、ヘリウム、アルゴン、二酸化炭素などの不活性ガスで希釈した酸素や空気、希釈空気を使用してもよい。また、酸素は系内で発生させてもよい。酸素の使用量は、通常、基質1モルに対して0.5モル以上(例えば、1モル以上)、好ましくは1~10000モル、さらに好ましくは5~1000モル程度である。基質に対して過剰モルの酸素を使用する場合が多い。
なお、反応系には、必要により、酸無水物を添加してもよい。酸無水物としては、例えば、無水酢酸、無水プロピオン酸、無水酪酸、無水イソ酪酸などの脂肪族モノカルボン酸無水物;無水安息香酸などの芳香族モノカルボン酸無水物;前記触媒の項で記載の酸無水物(脂肪族多価カルボン酸無水物、脂環式多価カルボン酸無水物、芳香族多価カルボン酸無水物)などが挙げられる。これらの酸無水物のうち、脂肪族モノカルボン酸無水物、特に無水酢酸が好ましい。酸無水物の使用量は、例えば、基質1モルに対して、0.1~100モル、好ましくは0.5~40モル、さらに好ましくは1~20モル程度であってもよい。酸無水物は基質に対して大過剰量用いることもできる。
本発明の方法では、前記の基質、すなわち、アルキル基及び/又はアルキレン基を有する芳香族化合物を酸素酸化することにより、アルキル基及び/又はアルキレン基が酸素酸化されて、基質に対応する酸化物、例えば、ヒドロキシ化合物(ベンジルアルコールなどの芳香族性環を有するアルカノール(C6-10アリールC1-4アルカノールなど)など)、アルデヒド化合物(芳香族アルデヒド、芳香族性環を有するアルカナールなど)、ケトン化合物(アセトフェノンなどのアリール-アルキル-ケトン;アラルキル-アルキル-ケトンなど)、有機酸(芳香族カルボン酸など)などが生成する。そして、前記ヒドロキシ化合物、アルデヒド(ホルミル)化合物及び/又はケトン化合物は、反応系でさらに酸素酸化される。ヒドロキシ化合物の酸化により、対応するアルデヒド化合物、ケトン化合物、有機酸などが生成し、アルデヒド化合物の酸化により対応する有機酸が形成する。さらに、ケトン類は酸化により解裂して、対応するアルデヒド(ホルミル)化合物、有機酸を生成する。そして、最終的に目的化合物である芳香族カルボン酸を得る。そのため、前記基質に対応するヒドロキシ化合物、アルデヒド化合物及びケトン化合物を酸化反応系における反応中間体と称する場合がある。
酸化反応において、前記触媒(イミド化合物)の使用量は、反応成分(基質;芳香族化合物)に対して、環状イミノユニット換算で、0.0001~100モル%程度の広い範囲で選択でき、例えば、基質に対して、0.0005~50モル%、好ましくは0.001~30モル%、さらに好ましくは0.005~10モル%程度であってもよい。なお、本発明では、反応効率を大幅に改善できるため、イミド化合物の使用量が少なくても、効率よく反応を進行させることができる。前記イミド化合物の使用量は、基質に対して、例えば、0.0002~5モル%、好ましくは0.0007~1モル%、さらに好ましくは0.001~0.5モル%程度であってもよい。また、触媒は、反応混合物に対して1~100,000ppm、好ましくは5~10,000ppm、さらに好ましくは10~5,000ppm程度の濃度となるように反応系に添加してもよい。
ディーンシュタークに類似の脱水装置を備えた空気流通型加圧式反応器に、p-キシレン300g(2.8モル)、酢酸コバルト(2価)0.20g(1.1ミリモル)及び酢酸マンガン(2価)0.20g(1.2ミリモル)を入れ、窒素を導入して昇圧し、圧力を0.5MPaにした。次いで、150℃に加熱し、オフガス中の酸素濃度が5%になるように空気と窒素とを混合したガスを、反応器に流通させた。別途調製したN-ヒドロキシスクシンイミド0.25g(2.2ミリモル)と水2gとの混合液を、反応器中に5時間かけて連続フィードした。なお、触媒の添加を開始した時点を、反応開始時点とし、触媒の添加が終了した時点を反応終了時点とした。また、反応は、水をトラップしつつ行った。反応終了後、反応器を冷却し、開圧して、反応混合物の高速液体クロマトグラフィー(HPLC)分析により、基質の転化率、生成物の収量及び収率を計算した。p-キシレンの転化率35.7%で、p-トルイル酸110g(収率28.9%)、テレフタル酸31g(収率6.68%)、副生成物の安息香酸0.32g(収率0.094%)が得られた。
N-ヒドロキシスクシンイミドと水との混合液に代えて、水2gを用いる以外は、実施例1と同様に、反応を行い、基質の転化率、生成物の収量・収率を計算した。なお、水の添加を開始した時点を、反応開始時点とし、水の添加が終了した時点を反応終了時点とした。反応の結果、p-キシレンの転化率1.68%で、p-トルイル酸5g(収率1.31%)、テレフタル酸1g(収率0.22%)、及び副生成物の安息香酸0.03g(収率0.0088%)が得られた。
N-ヒドロキシスクシンイミドに代えて、トリヒドロキシイソシアヌル酸0.025g(0.141ミリモル)を用いる以外は、実施例1と同様に、反応を行い、基質の転化率及び生成物の収量・収率を計算した。その結果、p-キシレンの転化率36.4%で、p-トルイル酸113g(収率29.7%)、テレフタル酸21g(収率4.52%)及び副生成物の安息香酸0.30g(収率0.0878%)が得られた。
p-キシレン300g(2.8モル)に加え、さらにp-トルイル酸10g(73.5ミリモル)を用いるとともに、酢酸マンガン(2価)及びN-ヒドロキシスクシンイミドの量をそれぞれ0.10g及び0.17gに変更する以外は、実施例1と同様に、反応を行い、基質の転化率及び生成物の収量を計算した。その結果、p-キシレンの転化率は48.9%であり、生成物の収量は、それぞれ、p-トルイル酸150g、テレフタル酸44g、及び副生成物の安息香酸0.40gであった。
N-ヒドロキシスクシンイミドと水との混合液に代えて、水2gを用いる以外は、実施例3と同様に、反応を行い、基質の転化率及び生成物の収量を計算した。なお、水の添加を開始した時点を、反応開始時点とし、水の添加が終了した時点を反応終了時点とした。その結果、p-キシレンの転化率は32.7%であり、生成物の収量は、それぞれ、p-トルイル酸90g、テレフタル酸32g、及び副生成物の安息香酸0.52gであった。
p-キシレン300gに代えて、p-トルイル酸メチル300g(2.0モル)を用いるとともに、反応系の圧力を0.2MPaに昇圧する以外は、実施例3と同様に、反応を行い、基質の転化率及び生成物の収量を計算した。その結果、p-トルイル酸メチルの転化率は30%であり、生成物の収量は、それぞれ、テレフタル酸モノメチル110g、テレフタル酸3.5g、及び副生成物の安息香酸メチル1gであった。なお、反応液中には、基質のp-トルイル酸メチルとともに用いたp-トルイル酸が7g残っていた。
N-ヒドロキシスクシンイミドと水との混合液に代えて、水2gを用いる以外は、実施例4と同様に、反応を行い、基質の転化率、生成物の収量を計算した。なお、水の添加を開始した時点を、反応開始時点とし、水の添加が終了した時点を反応終了時点とした。反応の結果、p-トルイル酸メチルの転化率は16%であり、生成物の収量は、それぞれ、テレフタル酸モノメチル53g、テレフタル酸2g、及び副生成物の安息香酸メチル1.2gであった。なお、反応液中には、基質のp-トルイル酸メチルとともに用いたp-トルイル酸が8g残っていた。
N-ヒドロキシスクシンイミドと水との混合液に代えて、N-ヒドロキシスクシンイミド0.17gと、p-トルイル酸メチル10gとの混合液を用い、この混合液を、反応器中に5時間かけてスラリーポンプで連続フィードする以外は、実施例4と同様に、反応を行い、基質の転化率及び生成物の収量を計算した。その結果、p-トルイル酸メチルの転化率は28.3%であり、生成物の収量は、それぞれ、テレフタル酸モノメチル115g、テレフタル酸3.5g、及び副生成物の安息香酸メチル1.0gであった。なお、反応液中には、基質のp-トルイル酸メチルとともに用いたp-トルイル酸が6g残っていた。
N-ヒドロキシスクシンイミド0.17gとp-トルイル酸メチル10gとの混合液に代えて、N-ヒドロキシスクシンイミド0.017gとp-トルイル酸メチル10gとの混合液を用いる以外は、実施例5と同様に、反応を行い、基質の転化率及び生成物の収量を計算した。その結果、p-トルイル酸メチルの転化率は22.3%であり、生成物の収量は、それぞれ、テレフタル酸モノメチル88g、テレフタル酸3.5g、及び副生成物の安息香酸メチル1.0gであった。なお、反応液中には、基質のp-トルイル酸メチルとともに用いたp-トルイル酸が7g残っていた。
p-トルイル酸メチル300g(2.0モル)及びp-トルイル酸10gに代えて、エチルベンゼン300g(2.8モル)を用いるとともに、反応系の圧力を0.4MPaに昇圧し、N-ヒドロキシスクシンイミド0.017gとp-トルイル酸メチル10gとの混合液に代えて、N-ヒドロキシスクシンイミド0.017gとアセトフェノン10gとの混合液を1時間かけて連続フィードする以外は、実施例6と同様に、反応を行い、基質の転化率及び生成物の収量を計算した。その結果、エチルベンゼンの転化率は27.0%であり、生成物の収量は、それぞれ、アセトフェノン32g及び安息香酸64gであった。
N-ヒドロキシスクシンイミド0.017gとアセトフェノン10gとの混合液に代えて、アセトフェノン10gを連続フィードする以外は、実施例7と同様に、反応を行い、基質の転化率及び生成物の収量を計算した。なお、アセトフェノンの添加を開始した時点を、反応開始時点とし、アセトフェノンの添加が終了した時点を反応終了時点とした。その結果、エチルベンゼンの転化率は6.74%であり、生成物の収量は、それぞれ、アセトフェノン16g及び安息香酸16gであった。
Claims (8)
- 下記式(1)
(式中、Xは酸素原子又は-OR基(Rは水素原子又はヒドロキシル基の保護基)を示し、「N」と「X」とを結ぶ実線と破線との二重線は単結合又は二重結合を示す)
で表される骨格を環の構成要素として含む窒素原子含有環状化合物で構成された触媒と、遷移金属助触媒との存在下、基質としてのアルキル基及び/又はアルキレン基を有する芳香族化合物を酸素酸化し、対応する芳香族カルボン酸を製造する方法であって、前記触媒と、基質、この基質の酸化反応により生成する反応中間体及び反応生成物から選択された少なくとも一種との混合物を、前記酸化反応系に逐次的又は連続的に供給しつつ、酸化反応を行う芳香族カルボン酸の製造方法。 - 反応溶媒の非存在下で酸化反応を行う請求項1記載の製造方法。
- 反応により生成する水を、反応系から除去しつつ反応させる請求項1又は2記載の製造方法。
- (a)触媒と、下記の(b-1)~(b-3)の成分から選択された少なくとも一種との混合物を、酸化反応系に逐次的又は連続的に供給しつつ、酸化反応を行う請求項1~3のいずれかの項に記載の製造方法。
(b-1)アルキル基及び/又はアルキレン基を有する芳香族化合物
(b-2)前記芳香族化合物に対応するカルボニル化合物
(b-3)水 - 触媒が、水溶性又は水分散性のイミド化合物であり、基質が、芳香環に1又は2個のC1-4アルキル基及び/又はC1-4アルキレン基が置換した芳香族化合物であり、酸化反応により生成した芳香族カルボン酸が、遷移金属助触媒と塩を形成可能である請求項1~4のいずれかの項に記載の製造方法。
- 触媒が、アルカンジカルボン酸イミド、アルケンカルボン酸イミド、及び少なくとも1つの窒素原子上に酸素原子又は-OR基(Rは請求項1に同じ)を有するイソシアヌル酸から選択された少なくとも一種である請求項1~5のいずれかの項に記載の製造方法。
- 遷移金属助触媒が、少なくとも周期表9族金属成分及び周期表7族金属成分を含む請求項1~6のいずれかの項に記載の製造方法。
- 遷移金属助触媒が、コバルト化合物とマンガン化合物とを含む請求項1~7のいずれかの項に記載の製造方法。
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KR101280135B1 (ko) | 2005-03-07 | 2013-06-28 | 가부시끼가이샤 다이셀 | 유기 화합물의 산화 방법 |
-
2009
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- 2009-05-21 WO PCT/JP2009/059366 patent/WO2009142269A1/ja active Application Filing
- 2009-05-21 CN CN200980128412.0A patent/CN102099324B/zh not_active Expired - Fee Related
- 2009-05-21 MX MX2010012734A patent/MX2010012734A/es not_active Application Discontinuation
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JP2001354596A (ja) * | 2000-06-14 | 2001-12-25 | Daicel Chem Ind Ltd | イミド化合物を触媒として用いた有機化合物の製造法 |
JP2002308805A (ja) * | 2001-04-11 | 2002-10-23 | Daicel Chem Ind Ltd | 芳香族カルボン酸及び/又は芳香族カルボン酸無水物の製造法 |
JP2005298380A (ja) * | 2004-04-08 | 2005-10-27 | Daicel Chem Ind Ltd | 芳香族カルボン酸の製造法 |
JP2006273793A (ja) * | 2005-03-30 | 2006-10-12 | Daicel Chem Ind Ltd | 環状アシルウレア系触媒を用いた有機化合物の製造方法 |
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"Abstracts of Annual Meeting of the Japan Petroleum Institute", vol. 43RD, 2000, pages: 115 - 116 * |
CSJ: THE CHEMICAL SOCIETY OF JAPAN KOEN YOKOSHU, vol. 74TH, no. 2, 1998, pages 1011 * |
J.ORG.CHEM, vol. 61, no. 14, 1996, pages 4520 - 4526 * |
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JPWO2009142269A1 (ja) | 2011-09-29 |
CN102099324B (zh) | 2017-03-08 |
CN102099324A (zh) | 2011-06-15 |
US9242921B2 (en) | 2016-01-26 |
JP5680959B2 (ja) | 2015-03-04 |
MX2010012734A (es) | 2010-12-07 |
DE112009001279T5 (de) | 2011-04-14 |
US20110071313A1 (en) | 2011-03-24 |
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