WO2009084234A1 - Préparation de feuille devant être appliquée sur le corps humain - Google Patents

Préparation de feuille devant être appliquée sur le corps humain Download PDF

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Publication number
WO2009084234A1
WO2009084234A1 PCT/JP2008/004029 JP2008004029W WO2009084234A1 WO 2009084234 A1 WO2009084234 A1 WO 2009084234A1 JP 2008004029 W JP2008004029 W JP 2008004029W WO 2009084234 A1 WO2009084234 A1 WO 2009084234A1
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Prior art keywords
water
layer
gel
skin
sheet
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PCT/JP2008/004029
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English (en)
Japanese (ja)
Inventor
Koji Uchida
Hideki Yokomichi
Hideki Mori
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Kao Corporation
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Priority to CN2008801219894A priority Critical patent/CN101903019A/zh
Priority claimed from JP2008333778A external-priority patent/JP5430146B2/ja
Publication of WO2009084234A1 publication Critical patent/WO2009084234A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Definitions

  • the present invention relates to a water-containing gel sheet used by being attached to the body.
  • a water-containing gel sheet made of a water-soluble polymer is used as one means for allowing an active ingredient for cosmetics or medical use to penetrate into the skin.
  • the hydrated gel sheet is particularly applied to uneven parts and movable parts of the body that require flexibility and elasticity derived from the material, and therefore studies have been made on improving adhesiveness and usability.
  • Patent Document 1 a hydrous gel sheet having exudate release properties using two types of water-soluble polymers as a gel base has been proposed (Patent Document 1). Since this gel sheet promotes the adhesion to the target surface by syneresis, no adhesive is required. Moreover, the liquid in a gel layer is discharge
  • Patent Document 2 a hydrogel sheet using a polyacrylic acid-based water-soluble polymer as a gel base has been proposed (Patent Document 2).
  • This gel sheet is less susceptible to changes in temperature (deformation) than gelatin-based gel sheets, has high extensibility, is difficult to tear, and is easily elastically deformed. Because it can be protected, it is used in many cosmetics and medical patches. Furthermore, the adhesiveness to the skin is also good.
  • the polyacrylic acid-based water-soluble polymer is a base having high water absorption and water retention, there is a problem in that when it is used in a hydrogel sheet, it cannot provide sufficient moisture to give the skin a moist feeling. there were.
  • the high extensibility becomes a factor of lowering the self-shape retaining property when the sheet is thinned, and means for suppressing the gel extensibility by stacking a woven fabric or a non-woven fabric as a support is required.
  • the woven fabric and non-woven fabric used as the support have lower extensibility and flexibility than the water-containing gel layer (sheet), and control the flexibility of the water-containing gel layer. There is a problem that the followability of the entire gel sheet is lowered with respect to the moving skin.
  • a water-containing gel sheet has been proposed in which a specific low-hydrophilic polyhydric alcohol is blended to promote water release and volatilization from a polyacrylic acid gel (Patent Document 3).
  • Patent Document 3 a specific low-hydrophilic polyhydric alcohol is blended to promote water release and volatilization from a polyacrylic acid gel.
  • a two-layered hydrogel sheet agent can be mentioned.
  • a technique relating to a two-layered hydrophilic patch in which a water-containing gel layer and a hydrophilic adhesive layer are sequentially laminated on one side of a plastic film through which water vapor permeates has been reported (Patent Document 4).
  • This gel sheet has a two-layer structure with an adhesive layer on the side of the application surface, but no specific method for forming an adhesive layer is shown, and the skin at the application site is actively moisturized. There is also no idea of giving moisture to the skin after peeling.
  • the plastic film support layer is less extensible and flexible than the hydrogel layer, which limits the flexibility of the hydrogel layer, and prevents uneven skin and movable skin such as elbows and knees. Therefore, the followability of the hydrophilic patch is inferior.
  • the plastic film and the hydrogel layer are not physically entangled and are bonded only by the interfacial tension. Therefore, the adhesive force of the plastic film to the hydrogel layer is weak, and the plastic film and the hydrogel layer are not used during use. Easy to peel.
  • the hydrophilic adhesive layer has, as an adhesive base, polyvinyl pyrrolidone, pullulan, poly (meth) acrylic acid, hydroxypropyl cellulose, methyl vinyl ether / maleic anhydride copolymer, polypropyl (meth) acrylate hydroxypropyl or the same series Uses a copolymer, carboxymethylated dendritic powder, etc. to supply moisture to the skin because it is designed to exhibit low adhesion or to exhibit adhesion with the addition of a plasticizer without moisture Difficult to do.
  • the adhesive base may remain on the skin after peeling, and the adhesive base remaining on the skin is in a state where powder is blown on the skin after drying.
  • the present invention relates to a body sticking sheet having a structure in which (A) a water-containing gel layer containing a crosslinked structure of an anionic polymer and (B) a moisturizing layer partially transferred onto the skin at the time of sticking are laminated.
  • the moisturizing layer is a gel-like layer containing 1.5 to 5% by weight of one or more hyaluronic acids selected from hyaluronic acid, hyaluronic acid decomposition products, hyaluronic acid derivatives and salts thereof.
  • the present invention provides a body patch.
  • the example of the shape of a tray is shown.
  • seat (state arrange
  • the problem of the present invention is that the retention property of the moisture retaining layer to the hydrated gel layer during storage is high, and has sufficient adhesiveness to the skin during use, followability to skin irregularities and movement and extensibility.
  • Another object of the present invention is to provide a sheet for body patching that can impart a moist feeling with almost no powder blowing by an adhesive base to the skin after application.
  • a two-layered sheet agent that uses a cross-linked structure of the above and laminates a moisturizing layer containing a certain amount of hyaluronic acid as a gel layer is partially transferred onto the skin when applied, and the water in the moisturizing layer is transferred. And hyaluronic acid is supplied to the skin, and the adhesiveness to the skin by the moisturizing layer is high, and has good followability to the unevenness and movement of the skin, as well as powder blowing after peeling and drying I found no skin residue.
  • the sheet for body sticking of the present invention has a gel-like moisturizing layer on the sticking surface, and therefore has good adhesion to the skin.
  • the moisturizing layer is in the form of a gel having a large amount of water, moisture is supplied from the moisturizing layer to the skin during application, and a moist feeling can be imparted to the peeled skin.
  • the water-containing gel layer holding a large amount of water is laminated on the moisturizing layer, the moisture supply to the skin is continued through the moisturizing layer.
  • the stratum corneum swells by supplying moisture to the skin, and hyaluronic acids contained in the moisturizing layer easily penetrate into the skin due to the occlusion effect of the hydrated gel layer.
  • a gel-like moisturizing layer containing moisture and hyaluronic acid remains on the skin as a ⁇ beauty liquid, '' so that more hyaluronic acid can be applied to the skin by spreading the moisturizing layer on the skin. While being able to supply, the hyaluronic acid and water-soluble polymer of a moisturizing layer remain locally, and the skin residue like powder blowing can be prevented.
  • the sheet for body patch of the present invention includes a hydrogel layer (A) containing a crosslinked structure of an anionic polymer, and a gel laminated on one side of the hydrogel layer, and a part of the gel is transferred onto the skin when applied. It has a two-layer structure with a moisturizing layer (B).
  • the water-containing gel layer (A) is a layer in which a water-containing gel is formed by a crosslinked structure of an anionic polymer, can serve as a support for a sheet agent, and serves as a moisture supply layer and a skin occlusion layer for the gel layer. It has the function of.
  • the crosslinked structure of the anionic polymer forms a dense network structure that becomes a basic skeleton of the hydrogel layer by chemically reacting the anionic polymer with the crosslinking agent by the anionic polymer, the crosslinking agent, and water. ing.
  • a water-containing gel layer formed by chemically cross-linking an anionic polymer is water-insoluble, but it retains a large amount of water in the network structure and swells, so it has moderate elasticity, extensibility, and flexibility. Have.
  • chemically crosslinked water-containing gels have less thermoplasticity than agar, etc., and are therefore stable in shape retention over a wide range of operating temperatures. Useful.
  • the thickness of the hydrogel layer of the sheet agent of the present invention is preferably 0.5 to 5 mm, more preferably 0.8 to 2 mm. It is preferable to have a thickness of at least 0.5 mm because moisture is provided from the hydrogel solution in order to dissolve the water-soluble film at the time of water retention and gel layer coating. Since it becomes easy to peel, it is preferable that it is 5 mm or less in thickness.
  • water-containing gel strength of the gel layer is preferably 1 ⁇ 18N / cm 2, further 1.5 ⁇ 10N / cm 2 In particular, 2 to 8 N / cm 2 is preferable.
  • the gel strength can be measured by the following method. The hydrogel before completion of the crosslinking reaction is filled into a cup container having a diameter of 60 mm ⁇ and a depth of 80 mm, and the crosslinking reaction is terminated as it is to prepare a cylindrical gel having a diameter of 60 mm ⁇ ⁇ height of 60 mm.
  • a plunger (diameter: 12 mm ⁇ , flat type) connected to a digital force gauge is brought into contact with the center of the upper surface of the cylindrical gel in the cup container, and the plunger is pushed into the gel by 30 mm at a constant speed of 300 mm / min.
  • F [N] is measured with a digital force gauge.
  • the gel strength is calculated by F / S [N / cm 2 ].
  • the water in the hydrogel layer may be natural water such as hot spring water or spring water, various water such as tap water, purified water, or ion exchange water.
  • the body patch sheet is formed by laminating two layers of a hydrated gel layer (A) and a moisturizing layer (B) to be described later. Will move between.
  • the amount of water contained in the hydrated gel layer is preferably 50 to 95% by weight, more preferably 55 to 90% by weight as the amount when the hydrated gel solution is blended. Within this range, the solubility and dispersibility of water, the gelling agent and other components are good, and it is suitable for workability, for example, coating.
  • the dispersion and solubility of the anionic polymer and other compounding bases will be insufficient, resulting in a decrease in workability during production and a decrease in the shape retention of the formed hydrous gel layer. Problems such as non-uniformity occur. Moreover, when there is too much the content, the shape retention property of a water-containing gel layer will fall, and malfunctions, such as a gel layer tearing at the time of use, will arise.
  • anionic polymer examples include polymers having a carboxyl group, a sulfate group, and a phosphate group.
  • anionic cellulose derivatives such as poly (meth) acrylic acids, carboxyvinyl polymer, carboxymethyl cellulose, carboxyethyl cellulose, carrageenan, alginic acid and salts thereof, anionic starch derivatives, and the like.
  • poly (meth) acrylic acids, anionic cellulose derivatives in order to obtain a water-containing gel layer that satisfies all of the high water retention, sufficient gel strength, and flexibility that can follow the unevenness and movement of the skin, It is preferable that at least one or more of carrageenan is included.
  • an anionic cellulose derivative, particularly carboxymethyl cellulose is preferred because the moisture balance between the hydrated gel layer and the moisturizing layer at the time of lamination can be easily controlled, and the moisture content of the moisturizing agent layer can be maintained high.
  • the content of the polymer is preferably 0.5 to 25% by weight, more preferably 3 to 10% by weight in the hydrogel solution.
  • the content of the functional polymer is preferably 0.5 to 6% by weight in the hydrogel solution.
  • a metal ion compound, a cationic polymer, or a polyfunctional epoxy compound can be used, and is appropriately selected depending on the reactivity with the functional group of the anionic polymer to be used.
  • the metal ion compound include oxides, hydroxides, and salts containing aluminum, magnesium, calcium, potassium, and the like.
  • These 1 type or 2 types or more can be mix
  • polyamino acids such as polylysine can be used.
  • Polyfunctional epoxy compounds include ethylene glycol diglycidyl ether, polyethylene glycol diglycidyl ether, glycerin diglycidyl ether, glycerin triglycidyl ether, propylene glycol diglycidyl ether, polyglycerol polyglycidyl ether, sorbitol polyglycidyl ether, sorbitan Examples thereof include polyglycidyl ether, trimethylolpropane polyglycidyl ether, pentaerythritol polyglycidyl ether, resorcinol diglycidyl ether, neopentyl glycol diglycidyl ether, and the like, and one or more of these can be used in combination.
  • an anionic cellulose derivative such as carboxymethylcellulose
  • an aluminum ion compound such as magnesium aluminate metasilicate and aluminum hydroxide is preferred as the crosslinking agent.
  • the content of the crosslinking agent in the water-containing gel layer is preferably 0.01 to 10% by weight, more preferably 0.05 to 5% by weight, and particularly preferably 0.1 to 2% by weight in the water-containing gel solution. .
  • hydrogel layer of the present invention in addition to water, an anionic polymer, and a crosslinking agent, if necessary, a water-soluble polymer, a humectant, an oil agent, as long as the crosslinked state and storage stability are not adversely affected.
  • surfactants, pH adjusters, medicinal ingredients, preservatives, antioxidants, ultraviolet absorbers, solubilizers, colorants, fragrances and the like can be appropriately blended.
  • the water-soluble polymer is appropriately blended for the purpose of, for example, adjusting the viscosity of an uncrosslinked gel or improving the shape retention of the crosslinked gel by being physically entangled with the network structure of the anionic polymer.
  • the water-soluble polymer used include natural polymers such as gelatin, agar, pectin, xanthan gum, locust bean gum, gellan gum, tragacanth gum, gum arabic, glucomannan, guar gum, HP guar gum, and tuberose polysaccharide; Polyvinyl compounds such as PVA, PVP, polyvinylpyrrolidone / vinyl acetate copolymer; nonionic cellulose derivatives such as methylcellulose, ethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose; soluble starch, pullulan, dextrin, hydroxy Examples thereof include starch degradation products such as alkyl starch and starch acetate
  • humectant examples include glycerin, diglycerin, polyglycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, methyl
  • examples include glucoside, polyoxyethylene methyl glucoside, erythritol, xylitol, sorbitol, mannitol, maltitol, trehalose and other polyhydric alcohols, sugar alcohols, saccharides, amino acids and derivatives thereof, proteins and derivatives thereof, etc. These can be used alone or in combination.
  • the content of the humectant is preferably 1 to 55% by weight, particularly preferably 1 to 40% by weight in the hydrogel solution. Since these humectants have a function as a dispersant for the anionic polymer at the time of preparing the hydrated gel, it is preferable to mix them in the hydrated gel solution.
  • Oils include jojoba oil, olive oil, avocado oil, mint oil, camellia oil, grape seed oil and other vegetable oils; mink oil, lanolin and other animal oils; liquid paraffin, squalane, squalene and other hydrocarbons; stearyl alcohol, isostearyl Higher alcohols such as alcohol and cetyl alcohol; ester oils such as isopropyl myristate, oleyl oleate and neopentyl glycol dicaprate; ether oils such as ethylene glycol dioctyl ether; dimethyl silicone oil, alcohol-modified silicone oil, alkyl-modified Silicone oils such as silicone oils and amino-modified silicone oils; fluorine oils such as perfluoropolyethers, and the like can be used, and one or more of these can be used in combination.
  • the amount of oil added depends on the cross-linked state and storage stability of the water-containing gel layer, and depending on the purpose of use, for example, supplying insufficient oil to the skin to prevent excessive moisture evaporation from the skin and moisturize.
  • the content of the oil agent is preferably in the range of 0.01 to 20% by weight in the hydrogel solution.
  • these oils can also be more easily distributed to the skin by being blended as an emulsion or solubilized product in the moisturizer layer on the sticking surface in the same manner as the moisturizer.
  • the surfactant is used for emulsifying or solubilizing the oil agent and uniformly dispersing it in the hydrous gel.
  • Surfactants are generally used for cosmetics, for example, anionic surfactants such as sodium dialkylsulfosuccinate, sodium dodecylbenzenesulfonate, alkyl sulfate ester salts; hexadecyltrimethylammonium chloride, octadecyldimethyl Cationic surfactants such as benzylammonium chloride; polyoxyethylene stearyl ether, polyoxyethylene octyldodecyl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, polyoxyethylene monostearate, sorbitan monostearate, Sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monolaurate, polyoxyethylene Nonionic surfact
  • pH adjusters include tartaric acid, succinic acid, citric acid, lactic acid, malic acid, acetic acid, glycolic acid, hydrochloric acid, oxalic acid, phosphoric acid, sodium hydroxide, potassium hydroxide, methylamine, dimethylamine, trimethylamine, ethylamine, Diethylamine, triethylamine, propylamine, dipropylamine, tripropylamine, monomethanolamine, dimethanolamine, trimethanolamine, monoethanolamine, diethanolamine, triethanolamine, monopropanolamine, dipropanolamine, tripropanolamine, citrate Acid salts, phosphates, carbonates and the like can be mentioned.
  • the pH of the water-containing gel layer is preferably adjusted in the range of 4 to 8, and the content of the pH adjuster is preferably in the range of 0.01 to 10% by weight in the water-containing gel solution.
  • Examples of medicinal ingredients include various skin beautifying ingredients and other medicinal ingredients.
  • the skin-beautifying component is a component in which actions such as a whitening effect, a fine wrinkle / sag improvement effect, a turnover improvement effect, a slimming effect, a moisturizing effect, an astringent effect, and an emollient effect are recognized.
  • these ingredients can also be added to the moisturizer layer on the affixing surface, thereby improving the distribution to the skin. Can be continuously supplied to the skin via
  • any of various active substances for skin beautifying used in cosmetics can be used, such as ceramides, vitamins (vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, and derivatives thereof.
  • Hyaluronic acid and salts thereof, chondroitin sulfate and salts thereof, tuberose polysaccharide, amino acids and derivatives and proteolysates thereof, organic acids such as hydroxy acids, glycoproteins such as lactoferrin, ubidecalenone (coenzyme Q10), ⁇ lipoic acid (Thioctic acid), animal and plant extracts, urea and the like can be mentioned, and these can be used alone or in combination.
  • the content of the beautifying skin component is preferably in the range of 0.01 to 20% by weight in the hydrogel solution.
  • Other medicinal ingredients are ingredients that are recognized to have effects such as blood circulation promoting action, anti-inflammatory analgesic action, and antipruritic action.
  • Examples of medicinal ingredients include nicotinic acid and its derivatives, vitamin E and its derivatives, salicylic acid and its salts, glycyrrhizic acid and its salts, allantoin, guaiazulene, diphenhydramine hydrochloride, lysozyme chloride, caffeine, carnitine, and the like. These 1 type (s) or 2 or more types can be used in combination.
  • the content of these medicinal ingredients is preferably in the range of 0.01 to 20% by weight in the hydrogel solution.
  • preservatives examples include paraoxybenzoic acid ester, benzoic acid and its salt, sorbic acid and its salt, dehydroacetate, phenol, isopropylmethylphenol, hinokitiol, benzalkonium chloride, benzethonium chloride, chlorhexidine chloride, etc. These can be used alone or in combination.
  • the content of the preservative is preferably in the range of 0.01 to 5% by weight in the hydrogel solution.
  • antioxidants examples include ascorbic acid and salts thereof, ascorbic acid ester, carotene, astaxanthin, propyl gallate, butylhydroxyanisole, dibutylhydroxytoluene, and the like, and one or more of these can be used in combination.
  • ultraviolet absorbers examples include paraaminobenzoic acid and its esters, amyl paradimethylaminobenzoate, oxybenzone, tetrahydroxybenzophenone, hydroxymethoxybenzophenonesulfonic acid, and cinoxalate.
  • a solubilizer is used to uniformly disperse a slightly water-soluble medicinal component in a water-containing gel, and specific examples thereof include lower alcohols such as ethyl alcohol, propyl alcohol, butyl alcohol, and benzyl alcohol.
  • Colors include Red No. 102 (New Cotion), Red No. 104- (1) (Phloxine B), Red No. 105- (1) (Rose Bengal), Red No. 106 (Assid Red), Red No. 2 ( Amaranth), Red 3 (Erythrosin), Yellow 4 (Tartrazine), Yellow 5 (Sunset Yellow FCF), Green 3 (Fast Green FCF), Blue 1 (Brilliant Blue FCF), Blue 2 (Indigo) And legal dyes such as carmine).
  • the fragrance is not particularly limited, and can be appropriately blended from fragrances that can be used in the fields of pharmaceuticals, quasi-drugs, cosmetics, sanitary materials, miscellaneous goods and the like.
  • the moisturizing layer (B) of the present invention is a viscous liquid (gel form) in which hyaluronic acids are dissolved or dispersed in water and do not gel in order to develop sufficient tackiness, A layer that is transferred to the skin. Transfer to the skin means that the moisturizing layer is transferred from the gel layer side of the sheet agent to the skin side when the moisturizing layer side of the sheet agent of the present invention is affixed to the skin and peeled off from the skin after a certain period of time. It means that the layer remains on the skin sufficiently.
  • the viscosity of the moisturizing layer (25 ° C.) is 100 to 1,000,000 mPa ⁇ s when a 20% aqueous solution of the moisturizing layer (B) is prepared from the viewpoint of adhesiveness to the skin during use and transferability to the skin. Further, it is preferably 300 to 800,000 mPa ⁇ s, particularly 500 to 600,000 mPa ⁇ s.
  • the viscosity is measured with a B-type viscometer.
  • the moisturizing layer (B) contains at least one selected from hyaluronic acid, hyaluronic acid decomposition products, hyaluronic acid derivatives, and salts thereof.
  • hyaluronic acid, hyaluronic acid degradation products, hyaluronic acid derivatives and salts thereof used in the moisturizing layer (B) of the present invention include, for example, heating and enzymatic degradation of hyaluronic acid, sodium hyaluronate, hyaluronic acid and sodium hyaluronate. Products, acetylated hyaluronic acid and the like.
  • the average molecular weight of these hyaluronic acids used is 5 million to 7 million for chicken hyacinth and 1 million to 3 million purified by microbial fermentation such as lactic acid bacteria, depending on the source of hyaluronic acid. It is preferable to use a degradation product of hyaluronic acid, acetylated hyaluronic acid, or the like, and it is preferable to use these in combination with hyaluronic acid or sodium hyaluronate.
  • the average molecular weight of the decomposition product of hyaluronic acid is preferably 5,000 to 1,500,000, more preferably 5,000 to 1,000,000, and particularly preferably 60,000 to 1,000,000.
  • hyaluronic acids are contained in the moisturizing layer (B) in an amount of 1.5 to 5% by weight, but the moisture in the moisturizing layer is stably retained on the hydrated gel layer to form a viscous liquid (gel). Further, 1.5 to 4% by weight, in particular, from the viewpoint of improving the adhesion at the time of application, transferring the gel-like material to the skin when the sheet is peeled off, and giving sufficient moisture retention without powder blowing or stickiness.
  • the content is preferably 8 to 3% by weight.
  • the moisture retention layer (B) has high adhesion at the time of application, has good transferability of the moisture retention layer, and swells the stratum corneum to impart moisture to improve the permeability of the active ingredient to the skin.
  • water is contained in an amount of 50 to 95% by weight, more preferably 55 to 90% by weight, particularly 60 to 80% by weight. If the moisture content in the moisturizing layer is small, the adhesiveness is good, but the swelling and permeability are poor. On the other hand, if the moisture content is excessive, the adhesiveness is lowered and the sheet agent is displaced.
  • the moisturizing layer (B) of the present invention further comprises a water-soluble polymer other than hyaluronic acid, powder, plasticizer, other moisturizing agent, oil agent, surfactant, pH adjuster, medicinal component, preservative, oxidation Inhibitors, ultraviolet absorbers, solubilizers, colorants, fragrances and the like can be appropriately blended.
  • the component used here can illustrate the same thing as the said hydrogel layer (A), and may be the same as that mix
  • the sheet for body patch of the present invention has a structure in which a water-containing gel layer (A) containing the anionic polymer and a moisture retention layer (B) containing hyaluronic acid are laminated, so that the moisture retention layer is transferred to the skin. It is preferably a viscous liquid (gel).
  • a method for producing such a sheet agent for example, by directly laminating an aqueous solution containing 1 to 5% by weight of hyaluronic acid forming the moisturizing layer (B) and the hydrogel layer (A).
  • Can be manufactured hereinafter referred to as manufacturing method X).
  • the moisture retaining layer (B) containing the hyaluronic acid is supplied in the state of a water-soluble film, and a part of the water-soluble film is formed by coating the water-containing gel layer (A) on the water-soluble film. It can also be obtained by dissolving (hereinafter referred to as production method Y).
  • the water-containing gel layer may be an anionic polymer water-containing gel layer before completion of the crosslinking reaction, and the crosslinking reaction may be completed after coating on the film.
  • the hyaluronic acid-containing aqueous solution constituting the moisturizing layer (B) is formed at the center of the tray having the shape of FIG. It is carried out by dripping and placing the hydrogel layer (A) thereon. Thereafter, when left for 24 to 72 hours, a part of the hyaluronic acid-containing aqueous solution penetrates into the water-containing gel layer to form a gel-like moisturizing layer.
  • the concentration of hyaluronic acid in the aqueous solution to be dropped is preferably 1 to 5% by mass, and in consideration of the transfer of moisture and low molecular weight substances between the water-containing gel layer and the moisturizing layer in the final form sheet agent, The concentration is preferably the same as the gel layer of the agent.
  • the moisture in the hydrogel layer (A) and the moisture in the hyaluronic acid-containing aqueous solution are the dissociation of the ions of the polymer in the hydrogel layer and the humectant such as a polyol optionally contained in the hydrogel layer.
  • the moisture content of the moisture-holding layer (B) is kept high, and each becomes an equilibrium moisture state. Seem.
  • the amount of the moisturizing layer containing hyaluronic acid formed on the surface of the gel layer in an equilibrium moisture state is 0.003 to 0 per unit area of the gel layer when the specific gravity of the moisturizing layer is 1. It ranges preferably .025g / cm 2, further preferably in the range of 0.005 ⁇ 0.02g / cm 2.
  • the water-soluble film when the moisture retaining layer is supplied in the form of a water-soluble film in advance, the water-soluble film preferably contains a water-soluble polymer in addition to the hyaluronic acids.
  • the gel-like moisturizing layer (B) absorbs and dissolves the water-soluble film by coating the water-containing gel layer (A) on the water-soluble film containing the water-soluble polymer and hyaluronic acid. Formed.
  • a film previously formed on a plastic liner is used as the water-soluble film.
  • the water-soluble film was processed so that the water-soluble polymer was present only in the concave portion of the plastic liner having embossed irregularities. It may be continuous water-soluble.
  • the water-soluble film used in the present invention forms a flexible film on a plastic liner.
  • the water-soluble film is preferably composed of a water-soluble polymer having a film forming ability.
  • the water-soluble polymer preferably has moisture retention and viscosity increase in addition to the film forming ability.
  • the water-soluble film of the present invention preferably includes a water-soluble powder having a molecular weight of less than 5000, a plasticizer, and water.
  • the water-soluble polymer used in the moisturizing layer (B) is preferably a polymer having an average molecular weight of 5,000 to 5,000,000 from the viewpoint of absorbing water and forming a gel layer.
  • the water-soluble polymer that can be used in the water-soluble film may overlap with the water-soluble polymer described above, but it is preferable that the water-soluble polymer does not form a cross-linked product by chemically reacting with the water-containing gel layer.
  • Such a water-soluble polymer is particularly preferably a water-soluble polymer having a high water-holding power, and specifically includes a molecular structure such as pectin, xanthan gum, gellan gum, gum arabic, alginic acid, alginate, etc.
  • Examples thereof include polysaccharides containing uronic acid and derivatives thereof; hydroxyalkylated cellulose; polyvinylpyrrolidone; starch degradation products or starch derivatives containing hydroxypropyl groups, phosphate groups, amino groups, and the like.
  • a starch degradation product a modified starch, a modified starch degradation product, a hydroxyalkylated cellulose, and polyvinylpyrrolidone (hereinafter referred to as PVP) having an average molecular weight of 5,000 to 300,000 are selected. More than species are preferred.
  • examples of the starch include natural starches such as tapioca starch, potato starch, corn starch, wheat starch, and rice starch. Further, high amylose corn starch, high amylose corn starch, mung bean starch, yellow pea and the like can also be used.
  • the modified starch include etherified starch, esterified starch, oxides thereof, and acid cross-linked products thereof.
  • the etherified starch is preferably a hydroxyalkylated starch such as a hydroxypropylated product, hydroxyethylated product, hydroxymethylated product, or hydroxypropylmethylated product
  • the esterified starch is preferably an acetylated starch.
  • oxides of etherified starch or esterified starch include those obtained by bleaching and oxidizing these starches with an oxidizing agent such as sodium hypochlorite.
  • Examples of acid-crosslinked products of etherified starch or esterified starch include phosphoric acid crosslinked products, adipic acid crosslinked products, and epichlorohydrin crosslinked products.
  • Examples of the degradation product of etherified starch or esterified starch include acid degradation products and enzymatic degradation products of those starches.
  • Examples of the acid decomposition products include those decomposed by immersion in an aqueous inorganic acid such as hydrochloric acid or sulfuric acid.
  • Examples of the enzymatic degradation products include amylase degradation products.
  • examples of the decomposition product of the oxide of etherified starch or esterified starch or the cross-linked product thereof include the same acid decomposition products and enzymatic decomposition products as described above.
  • hydroxyalkylated starches, oxides thereof, and acid cross-linked products thereof are particularly preferable.
  • These hydroxyalkylated starches or decomposition products thereof preferably have an average molecular weight of 5,000 to 100,000, particularly 10,000 to 50,000, in order to reduce film formation and remaining on a water gel. Is preferred.
  • the hydroxyalkylated cellulose is preferably a water-soluble hydroxyalkylcellulose such as hydroxypropylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, and has a molecular weight of 5,000 to 200,000, particularly 10,000 to 100,000, more preferably 10,000 to 60,000 are preferable.
  • Polyvinyl pyrrolidone (PVP) having an average molecular weight of 5,000 to 1,000,000 is widely available.
  • the average molecular weight is preferably 5,000 to 100,000, more preferably 5,000 to 60,000.
  • the content of these hydrolyzed starches having a molecular weight of 5,000 to 300,000, such as hydroxyalkylated cellulose and PVP, in the water-soluble film is preferably as much as possible from the viewpoint of film formation. Therefore, it is preferably 10 to 70% by weight, particularly 25 to 65% by weight, and more preferably 30 to 60% by weight.
  • the hyaluronic acid contained in the water-soluble film is 1 part by weight or more, and more preferably 1 to It is preferable to contain 30 parts by weight, further 2 to 15 parts by weight, and further 4 to 10 parts by weight.
  • a normal liquid or low molecule preferably a polyol or polysaccharide having an average molecular weight of less than 1000
  • specific examples include glycerin, polyglycerin, propylene glycol, alkyl glucoside, polyoxyethylene methyl glucoside, monosaccharide, oligosaccharide, sugar alcohol and the like, and one or more of these can be used.
  • polyoxypropylene (POP) or polyoxyethylene (POE) adducts of diglycerin and polyethylene glycol having an average molecular weight of less than 1,000 improve the blocking resistance of the water-soluble film and provide a moisturizing feeling to the skin. It is effective for grant.
  • the plasticizer is contained in an amount of 5 to 80 parts by weight, more preferably 5 to 50 parts by weight, particularly 10 to 30 parts by weight, based on 100 parts by weight of the water-soluble polymer, from the viewpoint of the flexibility and blocking resistance of the water-soluble film. Is preferred.
  • the polyalkylene glycol is preferably polyethylene glycol having an average molecular weight of 1000 to 6000, particularly preferably polyethylene glycol having an average molecular weight of 1000 to 4000 and more preferably an average molecular weight of 1200 to 3000.
  • These polyalkylene glycols do not increase viscosity when dissolved in water, do not inhibit film formation during drying, can improve blocking resistance, and are useful for retaining oil components. It is preferable that the molecular weight is not too small for the blocking resistance of film formation during drying. Moreover, it is preferable that the molecular weight is not too large in order to prevent the film from cracking.
  • polyalkylene glycol is dissolved in water together with plasticizer glycerin, and after dispersing hyaluronic acid and sodium hyaluronate, etc., which show high viscosity when dissolved in water, water is added so as not to become lumpy.
  • plasticizer alone has an upper limit of the blending amount in terms of blocking resistance, and when used in a quantity as a hyaluronic acid dispersant, the polyalkylene glycol is used in combination as a hyaluronic acid dispersant. It has the function of.
  • the polyalkylene glycol is preferably 5 to 80 parts by weight, more preferably 5 to 50 parts by weight, particularly 5 to 30 parts by weight, based on 100 parts by weight of the water-soluble polymer, from the viewpoint of blocking resistance and film temperature resistance. It is preferable to do this.
  • the total amount of the plasticizer and the polyalkylene glycol is preferably 20 to 140 parts by weight, particularly 30 to 100 parts by weight with respect to 100 parts by weight of the water-soluble polymer, from the viewpoint of blocking resistance and retention of moisturizing feeling on the skin. Parts, more preferably 40 to 80 parts by weight.
  • Hyaluronic acids are contained in an amount of 5 to 60 parts by weight, more preferably 5 to 30 parts by weight, especially 8 to 20 parts by weight, based on the total amount of plasticizer and polyalkylene glycol, from the viewpoint of gel layer formation and moisturizing feeling. It is preferable to do this.
  • a water-soluble film (water-soluble edible film) has a high molecular weight as an excipient in order to maintain sufficient shape retention even when it is peeled off from a coated plastic liner. Contains a large amount of molecules. Since the water-soluble film of the present invention is in a form in which the gel layer is laminated as a support in the sheet, the state where the plastic liner is used as the support, that is, the production stage of the sheet (the state where the plastic liner is applied) It is preferable that stable shape retention can be maintained. Therefore, it is preferable that the water-soluble film of the present invention further contains a low-molecular-weight water-soluble powder having almost no film forming ability by itself as an excipient for the film.
  • the low molecular weight water-soluble powder is compatible with the water that swells the crosslinked hydrogel layer, and easily dissolves in the hydrogel layer. Therefore, even when the gel layer is transferred to the skin, the so-called “powder” Because it is less likely to be blown ”and the dissolution rate in water is high, when a low-molecular weight water-soluble powder is blended, the water-soluble film quickly absorbs water from the water-containing gel layer and absorbs the water content. It becomes easy to form many gel layers. Therefore, in order to prepare the water-soluble film of the present invention, it is preferable to mix and use a low molecular weight water-soluble powder.
  • the low molecular weight water-soluble powder refers to a water-soluble powder having an average molecular weight of less than 5,000.
  • water-soluble powders examples include those obtained by decomposing the water-soluble polymer using an acid or an enzyme and reducing the average molecular weight to less than 5000, erythritol, xylitol, sorbitol, mannitol, maltitol, Examples include sugar alcohols such as trehalose, saccharides, amino acids, and derivatives thereof.
  • a starch degradation product having an average molecular weight of 100 or more and less than 1000 can be blended.
  • examples of the starch degradation product include starch acid degradation product and enzyme degradation product, and examples of the degradation product include dextrin.
  • the starch decomposition product more preferably has an average molecular weight of 200 or more and less than 1000.
  • DE (dextrose equivalence) is preferably 7 to 50, and DE 20 to 40 is particularly preferable.
  • the DE value increases as the decomposition proceeds and the amount of reducing sugar increases.
  • the weight ratio of the water-soluble polymer having film-forming ability in the water-soluble film to the water-soluble powder having a molecular weight of less than 5000 (water-soluble polymer: water-soluble powder) is preferably 1: 0.5 to 1:10. .
  • the total amount in the water-soluble film is preferably 40 to 80% by weight, particularly preferably 50 to 80% by weight.
  • the water-soluble film preferably has a content of 18 to 75% by weight, particularly 20 to 70% by weight, and more preferably 25 to 65% by weight from the viewpoint of improving the properties of the film and maintaining the shape retention of the film.
  • the water-soluble film before coating with the hydrogel preferably contains 15% by weight or less of water, particularly preferably 1 to 15% by weight, and more preferably 5 to 15% by weight.
  • the thickness of the water-soluble film is preferably in the range of 10 to 400 ⁇ m, preferably 20 to 100 ⁇ m, so that the sheet can be stably formed and dried.
  • the gel is applied again after applying a hydrous gel.
  • the thickness is preferably 20 to 70 ⁇ m from the viewpoint of forming a moisturizing layer.
  • a plastic liner used when preparing a water-soluble film a single layer or a multilayer film such as PE or nylon can be used in addition to a sheet material such as PET and PP that are usually used.
  • the surface shape of the liner is not particularly limited, and a flat liner or an embossed liner can be used.
  • the thickness of the liner is not particularly limited as long as it is suitable for workability, and is preferably in the range of 10 to 400 ⁇ m.
  • hydrophilic treatment such as corona discharge is performed on the surface on which the water-soluble film is laminated.
  • a method for producing a water-soluble film is prepared by preparing in advance an aqueous solution containing the above-mentioned hyaluronic acid, a water-soluble polymer other than hyaluronic acid, a water-soluble powder, a plasticizer, and other components, and preferably a hydrophilic solution subjected to corona discharge treatment.
  • a water-soluble film having a constant thickness is formed by coating and drying on a plastic liner having a conductive surface.
  • Such a water-soluble film can be prepared by directly applying the edible film production equipment and technology.
  • the sheet agent of the present invention is manufactured by coating a water-containing gel stock solution in which a component that forms a separately prepared water-containing gel layer (A) is mixed on a water-soluble film surface laminated on a plastic liner. can do.
  • a soluble water-soluble film absorbs and dissolves water in the coated hydrogel stock solution, and changes to a viscous gel.
  • the coating process of a hydrogel solution becomes simple.
  • the preparation of the sheet preparation is before the water-containing gel stock solution is cross-linked, after directly applying the water-containing gel stock solution to a separately prepared liner, and then overlaying the water-soluble film surface prepared thereon. May be.
  • the hydrogel stock solution may be extruded by a method such as sandwiching a water-soluble film and a plastic film at the same time.
  • the water-soluble film can be used not only on one side of the hydrated gel layer but also on both sides.
  • the solubility and composition of the water-soluble film it is possible to change the feel of the gel-like moisturizing layer formed by dissolving the water-soluble film and the moisture maintenance of the water-containing gel layer. I can do it.
  • a substrate other than the plastic film it is also possible to use.
  • hydrogel layer For the hydrogel layer to be coated on the water-soluble film, it is preferable to use a stock solution of the hydrogel before the completion of the crosslinking reaction, and it is preferable to terminate the crosslinking reaction after coating on the film.
  • the water-containing gel having a gel-like moisturizing layer is aged for several hours to several days at room temperature or warming (for example, 50 ° C.) to complete the crosslinking reaction of the water-containing gel layer. It can be set as a sheet for body sticking.
  • the gel-like moisturizing layer contains hyaluronic acid and water-soluble polymer and has low fluidity like the water-containing gel, so the uncrosslinked water-containing gel layer and the gel-like moisturizing layer are not completely and uniformly compatible.
  • the moisturizing layer also remains on the surface of the hydrogel layer after crosslinking. After the cross-linking reaction is completed, it is usually possible to perform die cutting and form the final shape (face mask or partial sheet).
  • the sheet agent of the present invention may be put in a tray container or the like after the sheet agent of the final form is put in a packaging container (pillow) or, if necessary, cut into a target shape. At this time, the film on one side or both sides can be peeled off and placed in a tray container to obtain a product form.
  • a gas such as carbon dioxide
  • the sheet is placed in a packaging container (pillow), and then the air in the packaging container (pillow) is replaced with carbon dioxide. Can be manufactured.
  • the filling amount of carbon dioxide in the packaging container is 0.5 to 5 times, preferably 1 to 3 times the volume of the gel in the sheet. Carbon dioxide that can be obtained can be sufficiently dissolved in the gel-like moisturizing layer and gel layer. In order to dissolve carbon dioxide in the gel-like moisture retaining layer and the gel-like moisture retaining layer, it is preferable to use a plastic film such as polyethylene or polypropylene having a gas permeability as high as possible on at least one side.
  • seat agent of this invention has a water-containing gel layer and a moisture retention layer, and a moisture retention layer is a sticking surface. It is possible to increase the concentration of the medicinal component of the moisturizing layer formed on the affixed surface as compared to the hydrogel layer, and to the skin rather than blending the medicinal component with the entire hydrogel layer like conventional single-layer gel sheets The distribution efficiency can be increased and more efficiently penetrated. Furthermore, there is a cost merit that the same effect can be expressed in a small amount, rather than blending medicinal ingredients into the entire hydrogel layer.
  • a plastic liner can be laminated on the surface of the hydrogel layer (A) to prevent moisture evaporation.
  • the obtained sheet material of the present invention can be used by peeling the plastic liner if necessary and sticking it on the body (face, etc.) using the moisturizing layer as the sticking surface. Since the moisturizing layer is a viscous liquid, a part thereof is transferred onto the skin after peeling. Therefore, the sheet agent of the present invention has good adhesiveness to the skin. Moreover, after sticking, you may hold
  • Examples 1 to 10 (1) Preparation of water-soluble film F-1 to F-5 stock solutions shown in Table 1 were prepared, and the stock solutions were kept at 40 to 60 ° C. and coated on a PET film using an applicator, and then 80 ° C. Was dried with hot air to obtain a water-soluble film. The film thickness was 20-40 ⁇ m.
  • stock solutions of F-6 and F-7 shown in Table 1 were prepared, and the stock solution was heated to 80 ° C or higher and dissolved by heating, and then the stock solution was kept at 50 ° C on an PET film using an applicator. After coating, the film was dried with hot air at 80 ° C. to obtain a water-soluble film.
  • the film thickness was 30-40 ⁇ m.
  • Table 2 shows the thickness of the water-soluble film, the amount of water in the film, and the amount of hyaluronic acid.
  • the moisture content was calculated by using the weight loss at 105 ° C. for 2 hours as the moisture content.
  • Comparative Example 1 The uncrosslinked hydrogel stock solution prepared in the Examples (same as the formulation in Table 2) is sandwiched between two ordinary PET films, and the thickness of the gel layer is set to 2 mm by a baker type applicator. It was extended. Furthermore, after aging at room temperature for 2 days to complete the crosslinking reaction of the hydrogel layer, it was cut into a 4 ⁇ 5 cm rectangular sheet to obtain a single-layer gel sheet without a gel-like moisture retention layer.
  • Mw 4 million
  • Comparative Examples 3-5 The F-5 to F-7 water-soluble film prepared in the above example was cut into a 4 ⁇ 5 cm rectangular sheet, and was applied to three 4 ⁇ 5 cm rectangular single-layer gel sheets without a moisturizing layer prepared in Comparative Example 1. Each of the PET films on one side is peeled off, and the rectangular water-soluble films F-5 to F-7 are laminated on the gel sheet surface that appears, and the same two-layer structure as the sheet agent reported in Patent Document 5 Gel sheets (3 types) were obtained. It was very troublesome to laminate a rectangular water-soluble film on a rectangular single-layer gel sheet without shifting.
  • the water-soluble film of F-5 was completely dissolved within 1 minute after being laminated on the single-layer gel sheet, and a viscous gel-like moisturizing layer was formed on the surface of the water-containing gel layer.
  • the soluble film was not completely dissolved even after 10 minutes. Further, it took about 5 minutes for the F-7 water-soluble film to completely dissolve.
  • the gel sheets having the moisture retention layer shown in Examples 1 to 10 showed good results in all evaluation items, but the moisture retention layer shown in Comparative Example 1 A single-layer gel sheet having no surface was insufficient particularly in stickiness and moisture. Furthermore, in the gel sheet having a two-layer structure having a hydrophilic pressure-sensitive adhesive layer, as shown in Comparative Example 2, good adhesiveness was realized, but all of the spreadability of the transfer material, powder blowing, and moist feeling It was insufficient.
  • the hyaluronic acid content in the moisturizing layer (B) of the gel sheet on the fourth day after aging in Examples 1 to 10 was peeled off the PET film on the moisturizing layer (B) side from the gel sheet cut into 20 ⁇ 25 cm, The PET film and the moisturizing layer (B) adhering to the hydrogel layer (A) were collected, and the nitrogen concentration was measured with a trace total nitrogen analyzer (TN-100) manufactured by Mitsubishi Chemical Corporation. The concentration of hyaluronic acid was calculated using this nitrogen content as the constituent nitrogen content of hyaluronic acid (Table 10).
  • the hyaluronic acid content of the sheets after aging storage in Examples 1 to 10 was between 1.6 and 2.7% by weight.
  • the PET film was peeled from the sheet 15 minutes after the water-soluble film and the gel sheet G-1 were laminated, and sampling was performed in the same manner to measure the nitrogen concentration.
  • the transfer of low molecular weight HP starch and starch hydrolyzate into the hydrogel layer (A) was still insufficient, and the hyaluronic acid content was as low as 0.8% by weight.
  • Examples 11 to 13 and Comparative Example 6 According to the composition of Table 11, preparation was performed by the following method. A product in which hyaluronic acid or a hydrolyzed product of hyaluronic acid is dispersed in a solution obtained by heating and dissolving glycerin, propylene glycol, diglycerin POE adduct and polyethylene glycol, and processed starch is dissolved in an equivalent amount to double the amount of water. Were coated on a PE film, dried, aged at 25 ° C. and a humidity of 40%, and the water-soluble film was evaluated.
  • Blocking resistance The water-soluble film dried and cooled in the state of being coated on the liner film was cut into A4, stacked, and stored in a container adjusted at 25 ° C. and 45% relative humidity and 45 ° C. relative humidity for 3 days, Evaluation was made according to the following criteria. ⁇ : Blocking does not occur and can be removed one by one. ⁇ : Blocking occurs, but the water-soluble film can be peeled off without being broken. X: It cannot block and peel off.
  • the water-containing gel solution (G-3) having the formulation shown in Table 12 was laminated with a water-soluble film with a liner film, stored for one week until the water-containing gel was crosslinked, cut into 3 ⁇ 4 cm, and applied to the skin. Thus, the portion where the water-soluble film became a gel-like moisture retention layer was evaluated. The results are shown in Table 11. The method for preparing and laminating the hydrogel will be described later.
  • Examples 14-18 A film having the composition shown in Table 13 was produced in the same manner as in Table 11.
  • the average molecular weight of polyvinylpyrrolidone (rubiscol K-30) is 45,000.
  • the preparation method and the evaluation method are the same as in Example 13.
  • the content of hyaluronic acid in the moisturizing layer was calculated by the following method, and the results are shown in Table 13. Similar to Examples 1 to 10, the sampled moisture retention layer was measured with a total nitrogen analyzer (TN-100), and the content of hyaluronic acid was produced from the obtained nitrogen content. Since pyrrolidone (rubiscol K-30) is also included, the amount of hyaluronic acid was calculated from the following experiment, assuming that polyvinylpyrrolidone was uniformly dispersed in the hydrous gel.
  • the content of hyaluronic acid in the formed moisturizing layer (B) is between 2.0 and 3.0% by weight, none of which is sticky, while phenomena such as powder blowing are also observed. I wouldn't.
  • Examples 19-20 ⁇ Method for adjusting hydrogel> It prepared with the kneading machine by the prescription shown in Table 14, and obtained the non-crosslinked water-containing gel before coating. In the preparation method, a mixed liquid of glycerin and propylene glycol was put into a kneader, carboxymethylcellulose, aluminum hydroxide, and methyl paraoxybenzoate were added in this order to prepare a slurry, and an aqueous succinic acid solution was further mixed.
  • This uncrosslinked water-containing gel was sandwiched between plastic (PET) films and spread by a baker type applicator so that the thickness of the gel layer was 2 mm. Aging was carried out at 50 ° C. for 5 days to complete the crosslinking reaction of the hydrogel layer to obtain a hydrogel sheet. Thereafter, die cutting was performed into an appropriate shape (for example, FIG. 2: area 32 cm 2 ).
  • the tray was designed so that two 32 cm 2 eye sheets could be placed (see FIGS. 1 and 2). From the 6 sheets of this tray, the moisturizing layer after aging for 3 days was collected, and the nitrogen concentration in the collected moisturizing layer was measured with a trace total nitrogen analyzer (TN-100, manufactured by Mitsubishi Chemical Corporation). The sodium hyaluronate content in the moisturizing layer was calculated from this nitrogen concentration. At this time, the calculation was performed assuming that 90% by weight of polyvinylpyrrolidone (K-90) remained in the moisture retaining layer. As a result, in the sheet agents of Examples 16 to 18, the sodium hyaluronate content in the moisturized layer after aging was 2.4 to 2.6% by weight as shown in Table 17. The results are shown in Table 17.

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Abstract

L'invention porte sur une préparation de feuille devant être appliquée sur le corps humain qui donne peu de résidu d'une base d'adhésif sensible à la pression sur la peau, qui présente un caractère collant suffisant sur la peau, une aptitude à suivre l'irrégularité ou le mouvement de la peau, et une excellente aptitude à l'extension, et qui peut conférer une sensation d'humidité à la peau par l'application. L'invention porte sur une préparation de feuille devant être appliquée sur le corps humain qui présente une structure stratifiée incluant (A) une couche de gel aqueux contenant une structure réticulée d'un polymère anionique et (B) une couche hydratante qui est partiellement transférée à la peau en application, la couche hydratante étant une couche de gel contenant de 1,5 à 5 % en poids d'au moins un composé acide hyaluronique choisi parmi l'acide hyaluronique, les produits de la décomposition de l'acide hyaluronique, les dérivés d'acide hyaluronique et les sels de ces composés.
PCT/JP2008/004029 2007-12-27 2008-12-26 Préparation de feuille devant être appliquée sur le corps humain WO2009084234A1 (fr)

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WO2016121611A1 (fr) * 2015-01-29 2016-08-04 株式会社リタファーマ Gel d'acide hyaluronique hydrosoluble et son procédé de production
JP2019073490A (ja) * 2017-10-19 2019-05-16 パナソニックＩｐマネジメント株式会社 機能性フィルムおよび皮膚貼付用シート、並びに皮膚貼付用シートの製造方法
US10661302B2 (en) 2013-12-31 2020-05-26 Johnson & Johnson Consumer Inc. Process for forming a shaped film product
US11247226B2 (en) 2013-12-31 2022-02-15 Johnson & Johnson Consumer Inc. Process for forming a multilayered shaped film product
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WO2015103034A1 (fr) * 2013-12-31 2015-07-09 Johnson & Johnson Consumer Companies, Inc. Procédé en une seule passe pour la formation d'un produit sous forme de film mis en forme multicouche
US9839939B2 (en) 2013-12-31 2017-12-12 Johnson & Johnson Consumer Inc. Single-pass process for forming a multilayered shaped film product
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JP2019073490A (ja) * 2017-10-19 2019-05-16 パナソニックＩｐマネジメント株式会社 機能性フィルムおよび皮膚貼付用シート、並びに皮膚貼付用シートの製造方法
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CN115335026A (zh) * 2020-04-07 2022-11-11 花王株式会社 含有碳酸气的含水凝胶物品的制造方法

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