JP4223531B2 - 予備成形ヒドロゲル製品を含む使用時調製デバイス - Google Patents
予備成形ヒドロゲル製品を含む使用時調製デバイス Download PDFInfo
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- JP4223531B2 JP4223531B2 JP2006533583A JP2006533583A JP4223531B2 JP 4223531 B2 JP4223531 B2 JP 4223531B2 JP 2006533583 A JP2006533583 A JP 2006533583A JP 2006533583 A JP2006533583 A JP 2006533583A JP 4223531 B2 JP4223531 B2 JP 4223531B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Description
既存の技術には、本発明の利点及び利益の全てを提供するものは存在しない。
(1)第1区画に包装されている予備成形ヒドロゲル構成成分であり、ゲル化剤及び溶媒を含む予備成形ヒドロゲル構成成分と、
(2)第2区画に包装されている利益構成成分であり、予備成形ヒドロゲル構成成分と接触すると不安定になる少なくとも1つの化合物を含む利益構成成分とを含み、
第1及び第2区画が、使用前に別個に包装されており、パッケージが、使用時に予備成形ヒドロゲル構成成分と利益構成成分を接触させる手段を含む、使用時調製デバイスを対象とする。
本発明の前述及びその他の特徴、態様、及び利点は、以下の説明及び添付の特許請求の範囲を読むことで、よりよく理解される。
全ての引用文献は、その全体が本明細書に参照として組み込まれるいかなる参照文献の引用も、特許請求する本発明に対する従来技術としての有用性の決定に関する容認ではない。
本発明は、好適には「使用時調製」用の製品と呼ばれる、使用時に、典型的には使用前の約60分以内、好ましくは約10分以内に最終製品を調製するように設計されたデバイスに関する。使用時調製デバイスは、当該技術分野において既知であり、使用時に互いに接触する中間構成成分を含む少なくとも2つの別個の区画を含む。使用時調製デバイスは、中間構成成分が、保管している間は互いに接触しないように設計される。更に、使用時調製デバイスのパッケージは、好ましくは、中間製品の混合のような最終製品の調製が、パッケージの区画の1つを使用して実施することができるように設計される。
本発明のデバイスは、予備成形ヒドロゲル構成成分を含む。本発明の予備成形ヒドロゲル構成成分は、手による取り扱いを可能にするか、皮膚、毛髪、又は爪、布地又は硬質表面の特定の目標領域の処置に適するか、経口投与又は消費を可能にする、構造及び形状を提供する。強度、可撓性、及び表面テキスチャーのような物理的性質が、予備成形ヒドロゲル構成成分が達成しようとする機能をかなえるように設計される。
本発明の予備成形ヒドロゲルは、構造及び形状を提供するゲル化剤を含む。予備成形ヒドロゲルに含まれるべきゲル化剤の種類及び量は、ゲル化剤の特性に応じて、製品の所望の特徴及び目的によって選択される。一般に、ゲル化剤が多いほど、より硬い予備成形ヒドロゲルが提供される。食品又は口腔投与用製品を提供するには、ゲル化剤は、食用でなければならず、味及び香りが許容可能でなければならない。多くの種類のゲル化剤が当該技術分野において既知であり、それにはポリマー系ゲル化剤、及び様々な種類の粘土類又は他のケイ酸塩に基づく材料のような微粒子系ゲル化剤が挙げられる。本明細書に極めて好ましいものは、水と組み合わされて三次元ゲル網状構造を形成するポリマー系ゲル化剤である。美容デバイスを提供するには、予備成形ヒドロゲルは、好ましくは約0.5%〜約20%、より好ましくは約1%〜約10%のゲル化剤を含む。
本発明の予備成形ヒドロゲルは、ゲル化剤のための溶媒を含み、それは水、水溶液又は水分散体であってよい。典型的には、ゲル化剤は、ゾル相の状態で溶媒に少なくとも混和性があり、最終的には均一な単層の予備成形ヒドロゲルを提供する。溶媒の量及び種類は、所望の機械的特性、特にゲル強度及び可撓性の観点から、また得られる製品の所望の特徴の観点から、ゲル化剤と共に安定なゲル相を提供するように決定される。好ましくは、溶媒は、更に予備成形ヒドロゲルのための可塑剤又は軟化剤として作用する。
口腔投与使用では、溶媒は、経口消費するのに安全で、好ましくは快適である、前述の群から選択される。
本発明のデバイスは、利益構成成分を含む。本発明の利益構成成分は、使用時に接触すると予備成形ヒドロゲル構成成分に追加的な利益を提供するが、予備成形ヒドロゲル構成成分と接触すると不安定になる少なくとも1つの化合物を含む。従って、最終ヒドロゲル製品は、使用時に調製される。利益構成成分は、液体、粉末又は固体、好ましくは液体又は粉末の形態であってよい。利益構成成分は、予備成形ヒドロゲル構成成分と接触すると、シネリシスを向上させ、硬化を促進するか、又は美的感覚をそこなう色、味、香り、及び/又は匂いを発生する化合物を含むことがある。利益構成成分は、予備成形ヒドロゲル構成成分に包含されている水と反応する中間化合物又は触媒を含んでよい。利益構成成分は、予備成形ヒドロゲル構成成分に容易に溶解/吸収されるか、又は予備成形ヒドロゲル構成成分から溶媒を吸収して、その物理的特性が直ちに変わるか又はその性能が減少する化合物を含んでよい。
極めて好ましい実施形態において、本発明の最終予備成形ヒドロゲル製品は、皮膚処理剤を皮膚、毛髪、又は爪に送達するのに有用なシート状貼付剤である。この製品は、一般に、各表面が約0.25cm2〜約1,000cm2、好ましくは約1cm2〜約400cm2の面積を有するような大きさである。表面積とは、表面と同一の境界を有する平らな平面、すなわち表面に存在するあらゆるテキスチャーを無視した平面の表面積を意味する。本明細書の予備成形ヒドロゲルは、目の周りの領域、瞼、鼻、口の周りの領域、額、頬、顎、顔の外表面全体、首、腕、体の他の特定の場所、又はこれらの組み合わせのような領域を覆うために、例えば、正方形、円形、半円形、長方形、楕円形、環状、三日月形、涙形、又はこれらの複合物でもよいさらに複雑な他の形状であることができる。予備成形ヒドロゲルは、それが適用される皮膚の表面に沿って適合するように十分に可撓性であるべきである。それにもかかわらず、例えば、ユーザーが製品を装着したときに垂れ下がった場合、予備成形ヒドロゲルが自重で破裂しないような最小ゲル強度が要求される。
(1)予備成形ヒドロゲル構成成分であり、
(a)約10%〜約99.5%の水と、
(b)約0.5%〜約20%の多糖類ゲル化剤とを含み、
予備成形ヒドロゲル構成成分が、支持基材を含まず、約0.1mm〜約5mm、好ましくは約0.5mm〜約2.0mmの厚さ、並びに第1表面及び第2表面を有し、第1表面が、約10μm〜約500μm、好ましくは約50μm〜約200μmの深さを、1mm当たり約0.2〜約1個、好ましくは1mm当たり約0.3〜約0.7個の頻度で有する反復テキスチャーを有し、テキスチャーの深さが、予備成形ヒドロゲル構成成分の厚さの少なくとも約10%である、予備成形ヒドロゲル構成成分;及び
(2)皮膚処理剤を含み、約1000mPa・s〜約100,000mPa・s、好ましくは約5000mPa・s〜約300,000mPa・sの粘度を有する利益構成成分、を含み、
反復テキスチャーが、第1表面が皮膚上に装着された時に利益構成成分の流体連通を可能にする、チャンネルのネットワークを提供するように設計されている、最終予備成形ヒドロゲル製品に関する。
極めて好ましい実施形態において、利益構成成分は、皮膚、毛髪又は爪のために少なくとも1つの皮膚処理剤を含む液体組成物である。好ましくは、予備成形ヒドロゲル構成成分と利益構成成分は、それぞれ少なくとも1つの共通の皮膚処理剤を含む。本発明の目的において、本明細書のこのセクションで考察される皮膚処理剤には、予備成形ヒドロゲル構成成分により不安定になる化合物は除外される。
本発明の最終ヒドロゲル製品は、皮膚に装着する直前に、好ましくは約10分以内に、上記の調製工程に従って調製される。最終ヒドロゲル製品の第1表面が皮膚上に装着され、これにより表面テキスチャーにより提供されるチャンネルのネットワークが、利益構成成分の流体連通を可能にする。このようにして得られた最終ヒドロゲル製品が皮膚、毛髪又は爪の標的領域に適用され、そして一般にその標的領域に約1分間〜約12時間、好ましくは約5〜約60分間放置される。
2ポリメチルシルセスキオキサン(Polymethylsilsesquioxane):東芝(Toshiba)製
3ジメチコーン、ジメチコノール、ラウレス−4、ラウレス−23、及び水:ダウ・コーニング社(Dow Corning)製
4水及びセチルベタイン:ロンザ社(Lonza)製
5水、トコフェリルアセテート、ポリソルベート80、カプリル酸/カプリン酸トリグリセリド、及びレシチン:チバ社(CIBA)製
6アルラトン(Arlatone)2121:ICI社製
7NaAMPS:ルブリゾール社(Lubrizol)製
8ダロキュア(Darocur)PI:チバ・ガイギー社(Ciba Geigy)
9IRR210XL:UCBケミカルズ社(UCB chemicals)製
10酵母発酵ろ液:カシワヤマ(Kashiwayama)から入手可能なSKIIピテラ(Pitera)
本明細書の使用時調製デバイスは、当該技術分野において既知のあらゆる好適なプロセスにより作られる。実施例1〜6のヒドロゲル構成成分は、局所使用の製品を提供するために、実施例7〜12のいずれかの利益構成成分と組み合わされてよい。実施例7〜11を利益構成成分として含む製品は、スキンケア製品として特に有用である。実施例12を利益構成成分として含む製品は、パウダーファンダーション製品として特に有用である。
(1)ゾル−ゲル転移点よりも少なくとも5℃高い温度で加熱された予備成形ヒドロゲル構成成分のゾル相組成物を準備する工程;
(2)ゾル相組成物をゾル−ゲル転移点よりも0℃〜5℃高い温度で予冷する工程;
(3)2本のライナーの間にゾル相組成物を押しつけて表面を形成する工程であり、2本のライナーが、互いに向かい合っている2つの逆回転ローラーにより供与され、ローラーが、更に冷却手段を含む、工程;
(4)ゾル相組成物を20℃以下の2つの温度で冷却してゲル相にする工程;及び
(5)ダイでゲル相組成物を切断する工程。
(6)各パッケージユニットが、第1区画と第2区画を有する、一連の封止されていないパッケージを準備する工程;
(7)パッケージの第2区画に利益構成成分を適用する工程;
(8)予備成形ヒドロゲル構成成分をパッケージの第1区画に配置する工程;
(9)パッケージを封止する工程;
(10)第1区画と第2区画を分離するパッケージ材料に切欠を設ける工程;及び
(11)各ユニットデバイスを分離するように穿孔を設ける工程。
最終予備成形ヒドロゲル製品は、シールを開けて、パッケージを切欠で折り畳み、予備成形ヒドロゲル構成成分を第2区画へ移動させて、利益構成成分と接触させることにより得られる。
このようにして得られた製品は、皮膚の標的領域に適用される。
本発明の特定の実施形態について説明し記載したが、本発明の精神及び範囲から逸脱することなく、その他の様々な変更及び修正を実施できることが、当業者には自明である。従って、本発明の範囲内にあるそのような全ての変更及び修正を、添付の特許請求の範囲で扱うものとする。
Claims (8)
- 局所使用のための使用時調製デバイスであって:
(1)第1区画に包装されている予備成形ヒドロゲル構成成分であり、ゲル化剤及び溶媒を含みおよび予備成形された形状を維持する予備成形ヒドロゲル構成成分と、
(2)第2区画に包装されている利益構成成分であり、予備成形ヒドロゲル構成成分と接触すると不安定になる少なくとも1つの化合物を含む利益構成成分と
を含み、
第1及び第2区画が、使用前に別個に包装されており、
デバイスが、使用時に予備成形ヒドロゲル構成成分と利益構成成分を接触させる手段を含み、
接触手段が、第1と第2区画の間に位置する切欠領域を含み、切欠領域が、ユーザーにより完全に破裂することなく折り畳めるように一定の強度を有し、および
第1及び第2区画の少なくとも1つがその内面にエンボス加工を有する、
局所使用のための使用時調製デバイス。 - 利益構成成分が、容易に酸化する水溶性化合物、熱発生化合物、粉末化合物、荷電化合物、気体形成化合物、及びこれらの混合物から成る群から選択される化合物を含む、請求項1に記載のデバイス。
- 予備成形ヒドロゲル構成成分が、調製のために第2区画に移動される、請求項1に記載のデバイス。
- 第1区画が、予備成形ヒドロゲル構成成分の放出を促進するために、内面にエンボス加工を有し、第2区画が、使用時に最終製品の調製を促進するために、内面にエンボス加工を有する、請求項1に記載のデバイス。
- 利益構成成分が、アスコルビン酸化合物を含む、請求項1に記載のデバイス。
- 利益構成成分が、熱発生化合物を含む、請求項1に記載のデバイス。
- (1)予備成形ヒドロゲル構成成分が:
(a)10%〜99.5%の水;及び
(b)0.5%〜20%の多糖類ゲル化剤を含み、
予備成形ヒドロゲル構成成分が、支持基材を含まず、
(2)利益構成成分がアスコルビン酸化合物を含む、
請求項1、5又は6のいずれか1項に記載のデバイス。 - (1)予備成形ヒドロゲル構成成分が:
(a)10%〜99.5%の水;及び
(b)0.5%〜20%の多糖類ゲル化剤を含み、
予備成形ヒドロゲル構成成分が、支持基材を含まず、0.1mm〜5mmの厚さ、並びに第1表面及び第2表面を有し、第1表面が、10μm〜500μmの深さを、1mm当たり0.2〜1個の頻度で有する反復テキスチャーを有し、テキスチャーの深さが、予備成形ヒドロゲル構成成分の厚さの少なくとも10%であり、
(2)利益構成成分が、アスコルビン酸化合物及び皮膚処理剤を含み、1000mPa・s〜100,000mPa・sの粘度を有し、
反復テキスチャーが、第1表面が皮膚上に装着された時に利益構成成分の流体連通を可能にする、チャンネルのネットワークを提供するように設計されている、
請求項1、5又は6のいずれか1項に記載のデバイス。
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2004
- 2004-06-07 CA CA002525786A patent/CA2525786A1/en not_active Abandoned
- 2004-06-07 CN CNB2004800161900A patent/CN100418516C/zh active Active
- 2004-06-07 EP EP04754556A patent/EP1633332A1/en not_active Withdrawn
- 2004-06-07 MX MXPA05013213A patent/MXPA05013213A/es unknown
- 2004-06-07 BR BRPI0411333-0A patent/BRPI0411333A/pt not_active Application Discontinuation
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JP2007501286A (ja) | 2007-01-25 |
US8353399B2 (en) | 2013-01-15 |
CN1805736A (zh) | 2006-07-19 |
US7854938B2 (en) | 2010-12-21 |
CA2525786A1 (en) | 2004-12-23 |
US20120041396A1 (en) | 2012-02-16 |
EP1633332A1 (en) | 2006-03-15 |
WO2004110414A1 (en) | 2004-12-23 |
KR20060016807A (ko) | 2006-02-22 |
BRPI0411333A (pt) | 2006-07-25 |
KR100738264B1 (ko) | 2007-07-12 |
AU2004247102A1 (en) | 2004-12-23 |
US20110056943A1 (en) | 2011-03-10 |
US8066117B2 (en) | 2011-11-29 |
US20040253313A1 (en) | 2004-12-16 |
MXPA05013213A (es) | 2006-03-09 |
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