WO2009072657A1 - ナノ機能性シリカ粒子およびその製造方法 - Google Patents

ナノ機能性シリカ粒子およびその製造方法 Download PDF

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Publication number
WO2009072657A1
WO2009072657A1 PCT/JP2008/072285 JP2008072285W WO2009072657A1 WO 2009072657 A1 WO2009072657 A1 WO 2009072657A1 JP 2008072285 W JP2008072285 W JP 2008072285W WO 2009072657 A1 WO2009072657 A1 WO 2009072657A1
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WO
WIPO (PCT)
Prior art keywords
nanofunctional
silica particles
mercaptopropyl
manufacturing
coating layer
Prior art date
Application number
PCT/JP2008/072285
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English (en)
French (fr)
Inventor
Michihiro Nakamura
Original Assignee
The University Of Tokushima
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of Tokushima filed Critical The University Of Tokushima
Priority to US12/734,968 priority Critical patent/US9265729B2/en
Priority to EP08856953.8A priority patent/EP2233437A4/en
Priority to JP2009544771A priority patent/JP5709292B2/ja
Publication of WO2009072657A1 publication Critical patent/WO2009072657A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/06—Preparatory processes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C08G77/28—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen sulfur-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/20—Polysiloxanes containing silicon bound to unsaturated aliphatic groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C08G77/26—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen nitrogen-containing groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2995—Silane, siloxane or silicone coating

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Silicon Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

【課題】 機能性と品質に優れ、しかも、低コストでの量産が可能なナノ機能性シリカ粒子を提供する。 【解決手段】 メルカプトプロピルトリメトキシシラン（ＭＰＳ）、メルカプトプロピルトリエトキシシラン（ＭＰＥＳ）、メルカプトプロピルメチルジメトキシシラン（ＭＰＤＭＳ）、トリメトキシ［２－（７－オキサビシクロ［４．１．０］－ヘプトー３－イル）エチル］シラン（ＥｐｏＰＳ）、チオシシアナトプロピルトリエトキシシラン（ＴＣＰＳ）およびアクリルオキシプロピルトリメトキシシラン（ＡＣＰＳ）からなる群より選択される１種または数種のシリカ化合物を含む被覆層と、前記被覆層内部に機能性粒子を含む、イメージングやアッセイ、診断、治療等、医療やバイオ研究等に利用される、ナノ機能性シリカ粒子が本発明によって提供される。  
PCT/JP2008/072285 2007-12-06 2008-12-08 ナノ機能性シリカ粒子およびその製造方法 WO2009072657A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/734,968 US9265729B2 (en) 2007-12-06 2008-12-08 Nanofunctional silica particles and manufacturing method thereof
EP08856953.8A EP2233437A4 (en) 2007-12-06 2008-12-08 NANOFUNCTIONAL SILICA PARTICLES AND METHOD FOR THE PRODUCTION THEREOF
JP2009544771A JP5709292B2 (ja) 2007-12-06 2008-12-08 ナノ機能性シリカ粒子およびその製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-316466 2007-12-06
JP2007316466 2007-12-06

Publications (1)

Publication Number Publication Date
WO2009072657A1 true WO2009072657A1 (ja) 2009-06-11

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PCT/JP2008/072285 WO2009072657A1 (ja) 2007-12-06 2008-12-08 ナノ機能性シリカ粒子およびその製造方法

Country Status (4)

Country Link
US (1) US9265729B2 (ja)
EP (1) EP2233437A4 (ja)
JP (1) JP5709292B2 (ja)
WO (1) WO2009072657A1 (ja)

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CN102192986A (zh) * 2010-03-19 2011-09-21 胡卫红 一种心肌肌钙蛋白i的检测试剂及其制备方法和用途
JP2011220705A (ja) * 2010-04-05 2011-11-04 Furukawa Electric Co Ltd:The イムノクロマトグラフィー用複合粒子
JP2011231200A (ja) * 2010-04-27 2011-11-17 Konica Minolta Medical & Graphic Inc 有機蛍光色素内包シリカナノ粒子、その製造方法、及びそれを用いた生体物質標識剤
JP2014153057A (ja) * 2013-02-04 2014-08-25 Furukawa Electric Co Ltd:The 標識抗体の製造方法
JP2016505475A (ja) * 2012-09-28 2016-02-25 ザ レジェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア 超音波イメージング／治療のための分解性シリカナノシェル
JP2016105066A (ja) * 2014-12-01 2016-06-09 三洋化成工業株式会社 磁性シリカ粒子、該磁性シリカ粒子を用いた測定対象物質測定方法及び測定対象物質測定用試薬
US10837018B2 (en) 2013-07-25 2020-11-17 Exicure, Inc. Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
CN112158851A (zh) * 2020-09-30 2021-01-01 武汉工程大学 一种异硫氰基功能化的二氧化硅材料的制备方法

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EP2031010B1 (en) * 2006-06-08 2014-04-23 The University of Tokushima Method for production of novel nano silica particle and use of the nano silica particle
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
WO2012118829A2 (en) 2011-02-28 2012-09-07 Novan, Inc. Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same
CA2892483A1 (en) * 2011-12-01 2013-06-06 Les Innovations Materium Silica microcapsules, process of making the same and uses thereof
CN106794256B (zh) * 2014-08-19 2021-04-30 西北大学 蛋白质/寡核苷酸核-壳纳米颗粒治疗剂
AU2015349680A1 (en) 2014-11-21 2017-06-08 Northwestern University The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
GB2552704A (en) * 2016-08-04 2018-02-07 Univ Bath Biomolecule preservation
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
US11433131B2 (en) 2017-05-11 2022-09-06 Northwestern University Adoptive cell therapy using spherical nucleic acids (SNAs)
US11964874B2 (en) 2020-06-09 2024-04-23 Agilent Technologies, Inc. Etched non-porous particles and method of producing thereof
CN115595146A (zh) * 2022-12-15 2023-01-13 中国人民解放军军事科学院军事医学研究院（Cn） 一种比色荧光双信号纳米微球及其制备方法与应用

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102192986A (zh) * 2010-03-19 2011-09-21 胡卫红 一种心肌肌钙蛋白i的检测试剂及其制备方法和用途
JP2011220705A (ja) * 2010-04-05 2011-11-04 Furukawa Electric Co Ltd:The イムノクロマトグラフィー用複合粒子
JP2011231200A (ja) * 2010-04-27 2011-11-17 Konica Minolta Medical & Graphic Inc 有機蛍光色素内包シリカナノ粒子、その製造方法、及びそれを用いた生体物質標識剤
JP2016505475A (ja) * 2012-09-28 2016-02-25 ザ レジェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア 超音波イメージング／治療のための分解性シリカナノシェル
JP2014153057A (ja) * 2013-02-04 2014-08-25 Furukawa Electric Co Ltd:The 標識抗体の製造方法
US10837018B2 (en) 2013-07-25 2020-11-17 Exicure, Inc. Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
US10894963B2 (en) 2013-07-25 2021-01-19 Exicure, Inc. Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
JP2016105066A (ja) * 2014-12-01 2016-06-09 三洋化成工業株式会社 磁性シリカ粒子、該磁性シリカ粒子を用いた測定対象物質測定方法及び測定対象物質測定用試薬
CN112158851A (zh) * 2020-09-30 2021-01-01 武汉工程大学 一种异硫氰基功能化的二氧化硅材料的制备方法
CN112158851B (zh) * 2020-09-30 2023-03-03 武汉工程大学 一种异硫氰基功能化的二氧化硅材料的制备方法

Also Published As

Publication number Publication date
EP2233437A4 (en) 2016-07-27
EP2233437A1 (en) 2010-09-29
JP5709292B2 (ja) 2015-04-30
JPWO2009072657A1 (ja) 2011-04-28
US9265729B2 (en) 2016-02-23
US20100310872A1 (en) 2010-12-09

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