WO2009072657A1 - ナノ機能性シリカ粒子およびその製造方法 - Google Patents

ナノ機能性シリカ粒子およびその製造方法 Download PDF

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Publication number
WO2009072657A1
WO2009072657A1 PCT/JP2008/072285 JP2008072285W WO2009072657A1 WO 2009072657 A1 WO2009072657 A1 WO 2009072657A1 JP 2008072285 W JP2008072285 W JP 2008072285W WO 2009072657 A1 WO2009072657 A1 WO 2009072657A1
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WO
WIPO (PCT)
Prior art keywords
nanofunctional
silica particles
mercaptopropyl
manufacturing
coating layer
Prior art date
Application number
PCT/JP2008/072285
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English (en)
French (fr)
Inventor
Michihiro Nakamura
Original Assignee
The University Of Tokushima
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of Tokushima filed Critical The University Of Tokushima
Priority to JP2009544771A priority Critical patent/JP5709292B2/ja
Priority to US12/734,968 priority patent/US9265729B2/en
Priority to EP08856953.8A priority patent/EP2233437A4/en
Publication of WO2009072657A1 publication Critical patent/WO2009072657A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/06—Preparatory processes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C08G77/28—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen sulfur-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/20—Polysiloxanes containing silicon bound to unsaturated aliphatic groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C08G77/26—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen nitrogen-containing groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2995—Silane, siloxane or silicone coating

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Silicon Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

【課題】 機能性と品質に優れ、しかも、低コストでの量産が可能なナノ機能性シリカ粒子を提供する。 【解決手段】 メルカプトプロピルトリメトキシシラン（ＭＰＳ）、メルカプトプロピルトリエトキシシラン（ＭＰＥＳ）、メルカプトプロピルメチルジメトキシシラン（ＭＰＤＭＳ）、トリメトキシ［２－（７－オキサビシクロ［４．１．０］－ヘプトー３－イル）エチル］シラン（ＥｐｏＰＳ）、チオシシアナトプロピルトリエトキシシラン（ＴＣＰＳ）およびアクリルオキシプロピルトリメトキシシラン（ＡＣＰＳ）からなる群より選択される１種または数種のシリカ化合物を含む被覆層と、前記被覆層内部に機能性粒子を含む、イメージングやアッセイ、診断、治療等、医療やバイオ研究等に利用される、ナノ機能性シリカ粒子が本発明によって提供される。  
PCT/JP2008/072285 2007-12-06 2008-12-08 ナノ機能性シリカ粒子およびその製造方法 WO2009072657A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009544771A JP5709292B2 (ja) 2007-12-06 2008-12-08 ナノ機能性シリカ粒子およびその製造方法
US12/734,968 US9265729B2 (en) 2007-12-06 2008-12-08 Nanofunctional silica particles and manufacturing method thereof
EP08856953.8A EP2233437A4 (en) 2007-12-06 2008-12-08 NANOFUNCTIONAL SILICA PARTICLES AND METHOD FOR THE PRODUCTION THEREOF

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-316466 2007-12-06
JP2007316466 2007-12-06

Publications (1)

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WO2009072657A1 true WO2009072657A1 (ja) 2009-06-11

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Country Status (4)

Country Link
US (1) US9265729B2 (ja)
EP (1) EP2233437A4 (ja)
JP (1) JP5709292B2 (ja)
WO (1) WO2009072657A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102192986A (zh) * 2010-03-19 2011-09-21 胡卫红 一种心肌肌钙蛋白i的检测试剂及其制备方法和用途
JP2011220705A (ja) * 2010-04-05 2011-11-04 Furukawa Electric Co Ltd:The イムノクロマトグラフィー用複合粒子
JP2011231200A (ja) * 2010-04-27 2011-11-17 Konica Minolta Medical & Graphic Inc 有機蛍光色素内包シリカナノ粒子、その製造方法、及びそれを用いた生体物質標識剤
JP2014153057A (ja) * 2013-02-04 2014-08-25 Furukawa Electric Co Ltd:The 標識抗体の製造方法
JP2016505475A (ja) * 2012-09-28 2016-02-25 ザ レジェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア 超音波イメージング／治療のための分解性シリカナノシェル
JP2016105066A (ja) * 2014-12-01 2016-06-09 三洋化成工業株式会社 磁性シリカ粒子、該磁性シリカ粒子を用いた測定対象物質測定方法及び測定対象物質測定用試薬
US10837018B2 (en) 2013-07-25 2020-11-17 Exicure, Inc. Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
CN112158851A (zh) * 2020-09-30 2021-01-01 武汉工程大学 一种异硫氰基功能化的二氧化硅材料的制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007142316A1 (ja) * 2006-06-08 2007-12-13 The University Of Tokushima 新規なナノシリカ粒子の製造方法と用途
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
EP2681286B1 (en) * 2011-02-28 2018-08-15 Novan, Inc. Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same
EP2785444A4 (en) * 2011-12-01 2015-08-19 Innovations Materium SILICA MICRO-CAPSULES, METHOD FOR THEIR PRODUCTION AND USE
JP6797108B2 (ja) * 2014-08-19 2020-12-09 ノースウェスタン ユニバーシティ タンパク質／オリゴヌクレオチドコアシェルナノ粒子治療薬
CN107106493A (zh) 2014-11-21 2017-08-29 西北大学 球形核酸纳米颗粒缀合物的序列特异性细胞摄取
GB2552704A (en) * 2016-08-04 2018-02-07 Univ Bath Biomolecule preservation
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
US11433131B2 (en) 2017-05-11 2022-09-06 Northwestern University Adoptive cell therapy using spherical nucleic acids (SNAs)
US11964874B2 (en) 2020-06-09 2024-04-23 Agilent Technologies, Inc. Etched non-porous particles and method of producing thereof
CN115595146A (zh) * 2022-12-15 2023-01-13 中国人民解放军军事科学院军事医学研究院（Cn） 一种比色荧光双信号纳米微球及其制备方法与应用

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001520937A (ja) * 1997-10-28 2001-11-06 ザ・ユニヴァシティ・オブ・メルボルン 安定化粒子、その製造方法、およびその用途
WO2003002633A1 (en) 2001-06-29 2003-01-09 Nanomics Biosystems Pty, Ltd. Synthesis and use of organosilica particles
WO2003060037A1 (fr) * 2001-12-27 2003-07-24 Techno Network Shikoku Co., Ltd. Spheres de silice contenant des molecules de colorant fluorescent
JP2003253154A (ja) * 2001-12-25 2003-09-10 Asahi Kasei Corp 無機多孔性微粒子
JP2003270154A (ja) * 2001-12-27 2003-09-25 Techno Network Shikoku Co Ltd 蛍光色素分子含有シリカ球
JP2005538033A (ja) * 2001-12-04 2005-12-15 ナノスペクトラ バイオサイエンセズ，インク． 過剰なあるいは不適切な新脈管形成によって特徴付けられる病状の治療
JP2006160107A (ja) 2004-12-08 2006-06-22 Sumitomo Rubber Ind Ltd 空気入りタイヤ
WO2006070582A1 (ja) 2004-12-09 2006-07-06 Techno Network Shikoku. Co., Ltd. 標識分子含有シリカ球の調製方法
WO2007074722A1 (ja) * 2005-12-27 2007-07-05 The Furukawa Electric Co., Ltd. 蛍光ナノシリカ粒子、ナノ蛍光材料、それを用いたバイオチップ及びそのアッセイ法
WO2007097377A1 (ja) * 2006-02-24 2007-08-30 The Furukawa Electric Co., Ltd. フローサイトメトリーによる生体分子の定量システム、その定量方法、細胞の検出・分取システム、その検出・分取方法、それらに用いる蛍光シリカ粒子、及び複数個の蛍光シリカ粒子を組み合わせたキット
WO2007142316A1 (ja) * 2006-06-08 2007-12-13 The University Of Tokushima 新規なナノシリカ粒子の製造方法と用途
JP2008311141A (ja) * 2007-06-15 2008-12-25 Jgc Catalysts & Chemicals Ltd 導電性粒子の製造方法および導電性粒子
JP2008308371A (ja) * 2007-06-15 2008-12-25 Hokkaido Univ 異方形状粒子および該粒子の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3616133A1 (de) * 1985-09-25 1987-11-19 Merck Patent Gmbh Kugelfoermige sio(pfeil abwaerts)2(pfeil abwaerts)-partikel
JPH10160737A (ja) * 1996-12-03 1998-06-19 Dainippon Printing Co Ltd 光学的分析装置用測定チップ及びその製造方法
EP1226422B1 (en) * 1999-10-06 2007-11-28 Oxonica Inc. Surface enhanced spectroscopy-active composite nanoparticles
US20040101822A1 (en) * 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
DE102004011110A1 (de) * 2004-03-08 2005-09-22 Merck Patent Gmbh Verfahren zur Herstellung monodisperser SiO2-Partikel
US7534489B2 (en) * 2004-09-24 2009-05-19 Agency For Science, Technology And Research Coated composites of magnetic material and quantum dots
WO2008154332A1 (en) * 2007-06-06 2008-12-18 Becton, Dickinson And Company Near-infrared dyes as surface enhanced raman scattering reporters

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001520937A (ja) * 1997-10-28 2001-11-06 ザ・ユニヴァシティ・オブ・メルボルン 安定化粒子、その製造方法、およびその用途
WO2003002633A1 (en) 2001-06-29 2003-01-09 Nanomics Biosystems Pty, Ltd. Synthesis and use of organosilica particles
JP2005538033A (ja) * 2001-12-04 2005-12-15 ナノスペクトラ バイオサイエンセズ，インク． 過剰なあるいは不適切な新脈管形成によって特徴付けられる病状の治療
JP2003253154A (ja) * 2001-12-25 2003-09-10 Asahi Kasei Corp 無機多孔性微粒子
WO2003060037A1 (fr) * 2001-12-27 2003-07-24 Techno Network Shikoku Co., Ltd. Spheres de silice contenant des molecules de colorant fluorescent
JP2003270154A (ja) * 2001-12-27 2003-09-25 Techno Network Shikoku Co Ltd 蛍光色素分子含有シリカ球
JP2006160107A (ja) 2004-12-08 2006-06-22 Sumitomo Rubber Ind Ltd 空気入りタイヤ
WO2006070582A1 (ja) 2004-12-09 2006-07-06 Techno Network Shikoku. Co., Ltd. 標識分子含有シリカ球の調製方法
WO2007074722A1 (ja) * 2005-12-27 2007-07-05 The Furukawa Electric Co., Ltd. 蛍光ナノシリカ粒子、ナノ蛍光材料、それを用いたバイオチップ及びそのアッセイ法
WO2007097377A1 (ja) * 2006-02-24 2007-08-30 The Furukawa Electric Co., Ltd. フローサイトメトリーによる生体分子の定量システム、その定量方法、細胞の検出・分取システム、その検出・分取方法、それらに用いる蛍光シリカ粒子、及び複数個の蛍光シリカ粒子を組み合わせたキット
JP2009014730A (ja) * 2006-02-24 2009-01-22 Furukawa Electric Co Ltd:The フローサイトメトリーによる生体分子の定量又は細胞の検出・分取に用いる蛍光シリカ粒子、及び複数個の蛍光シリカ粒子を組み合わせたキット
JP2009014729A (ja) * 2006-02-24 2009-01-22 Furukawa Electric Co Ltd:The フローサイトメトリーによる細胞の検出・分取システム、及び検出・分取方法
WO2007142316A1 (ja) * 2006-06-08 2007-12-13 The University Of Tokushima 新規なナノシリカ粒子の製造方法と用途
JP2008311141A (ja) * 2007-06-15 2008-12-25 Jgc Catalysts & Chemicals Ltd 導電性粒子の製造方法および導電性粒子
JP2008308371A (ja) * 2007-06-15 2008-12-25 Hokkaido Univ 異方形状粒子および該粒子の製造方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 46, 2007, pages 3680 - 3682
JOURNAL OF AMERICA CHEMICAL SOCIETY, vol. 129, 2007, pages 8962 - 8963
See also references of EP2233437A4 *
STOBER, W.; FINK, A.; BOHN, E., J. COLLOID INTERFACE SCI., vol. 26, 1968, pages 62 - 69

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102192986A (zh) * 2010-03-19 2011-09-21 胡卫红 一种心肌肌钙蛋白i的检测试剂及其制备方法和用途
JP2011220705A (ja) * 2010-04-05 2011-11-04 Furukawa Electric Co Ltd:The イムノクロマトグラフィー用複合粒子
JP2011231200A (ja) * 2010-04-27 2011-11-17 Konica Minolta Medical & Graphic Inc 有機蛍光色素内包シリカナノ粒子、その製造方法、及びそれを用いた生体物質標識剤
JP2016505475A (ja) * 2012-09-28 2016-02-25 ザ レジェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア 超音波イメージング／治療のための分解性シリカナノシェル
JP2014153057A (ja) * 2013-02-04 2014-08-25 Furukawa Electric Co Ltd:The 標識抗体の製造方法
US10837018B2 (en) 2013-07-25 2020-11-17 Exicure, Inc. Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
US10894963B2 (en) 2013-07-25 2021-01-19 Exicure, Inc. Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
JP2016105066A (ja) * 2014-12-01 2016-06-09 三洋化成工業株式会社 磁性シリカ粒子、該磁性シリカ粒子を用いた測定対象物質測定方法及び測定対象物質測定用試薬
CN112158851A (zh) * 2020-09-30 2021-01-01 武汉工程大学 一种异硫氰基功能化的二氧化硅材料的制备方法
CN112158851B (zh) * 2020-09-30 2023-03-03 武汉工程大学 一种异硫氰基功能化的二氧化硅材料的制备方法

Also Published As

Publication number Publication date
EP2233437A4 (en) 2016-07-27
JP5709292B2 (ja) 2015-04-30
US20100310872A1 (en) 2010-12-09
JPWO2009072657A1 (ja) 2011-04-28
US9265729B2 (en) 2016-02-23
EP2233437A1 (en) 2010-09-29

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