WO2009072562A1 - 有機酸の製造方法 - Google Patents

有機酸の製造方法 Download PDF

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Publication number
WO2009072562A1
WO2009072562A1 PCT/JP2008/072055 JP2008072055W WO2009072562A1 WO 2009072562 A1 WO2009072562 A1 WO 2009072562A1 JP 2008072055 W JP2008072055 W JP 2008072055W WO 2009072562 A1 WO2009072562 A1 WO 2009072562A1
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WO
WIPO (PCT)
Prior art keywords
organic acid
bacterium
belongs
producing
production
Prior art date
Application number
PCT/JP2008/072055
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English (en)
French (fr)
Inventor
Yoshinori Tajima
Keita Fukui
Kenichi Hashiguchi
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Priority to JP2009544711A priority Critical patent/JP5644108B2/ja
Priority to EP08857657.4A priority patent/EP2241630B1/en
Publication of WO2009072562A1 publication Critical patent/WO2009072562A1/ja
Priority to US12/793,107 priority patent/US8247201B2/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10Alpha-amino-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44Polycarboxylic acids
    • C12P7/46Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/01Carboxy-lyases (4.1.1)
    • C12Y401/01031Phosphoenolpyruvate carboxylase (4.1.1.31)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polyamides (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ホスホエノールピルビン酸カルボキシキナーゼ活性が増強するように改変された有機酸生産能を有する腸内細菌科に属する細菌であって、エンテロバクター属、パントエア属、エルビニア属、クレブシエラ属、及びラウルテラ属から選択される細菌、又は該細菌の処理物を、炭酸イオン、重炭酸イオン、または二酸化炭素ガスを含有する反応液中で有機原料に作用させることによって、有機酸を生成させ、該有機酸を採取することにより、有機酸を製造する。                                                                    
PCT/JP2008/072055 2007-12-06 2008-12-04 有機酸の製造方法 WO2009072562A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009544711A JP5644108B2 (ja) 2007-12-06 2008-12-04 有機酸の製造方法
EP08857657.4A EP2241630B1 (en) 2007-12-06 2008-12-04 A method for producing an organic acid
US12/793,107 US8247201B2 (en) 2007-12-06 2010-06-03 Method for producing an organic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007315764 2007-12-06
JP2007-315764 2007-12-06

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/793,107 Continuation US8247201B2 (en) 2007-12-06 2010-06-03 Method for producing an organic acid

Publications (1)

Publication Number Publication Date
WO2009072562A1 true WO2009072562A1 (ja) 2009-06-11

Family

ID=40717739

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/072055 WO2009072562A1 (ja) 2007-12-06 2008-12-04 有機酸の製造方法

Country Status (4)

Country Link
US (1) US8247201B2 (ja)
EP (1) EP2241630B1 (ja)
JP (1) JP5644108B2 (ja)
WO (1) WO2009072562A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012019175A3 (en) * 2010-08-06 2012-04-19 Mascoma Corporation Production of malonyl-coa drived products via anaerobic pathways
US8247201B2 (en) 2007-12-06 2012-08-21 Ajinomoto Co., Inc. Method for producing an organic acid
JP2012522515A (ja) * 2009-04-02 2012-09-27 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド コハク酸生産経路の工学処理
JP2014150747A (ja) * 2013-02-06 2014-08-25 Sekisui Chem Co Ltd 変異微生物、並びに、コハク酸の生産方法
WO2015005406A1 (ja) 2013-07-09 2015-01-15 味の素株式会社 有用物質の製造方法
WO2016104814A2 (en) 2014-12-26 2016-06-30 Ajinomoto Co., Inc. Method for producing dicarboxylic acid

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010137130A1 (ja) 2009-05-27 2010-12-02 味の素株式会社 有機酸の製造方法
KR20160114184A (ko) 2009-11-18 2016-10-04 미리안트 코포레이션 화합물들의 효과적인 생산을 위한 미생물 엔지니어링
EP2821479A4 (en) 2012-02-29 2015-09-02 Ajinomoto Kk ESCHERICHIA COLI WITH THE PRODUCTIVITY OF 3-AMINO-4-HYDROXYBENZOIC ACID
JP6183358B2 (ja) 2012-05-29 2017-08-23 味の素株式会社 3−アセチルアミノ−4−ヒドロキシ安息香酸の製造方法
BR112021005543A2 (pt) 2018-09-28 2021-06-29 Ajinomoto Co., Inc. método para produzir l-metionina
WO2020171227A1 (en) 2019-02-22 2020-08-27 Ajinomoto Co., Inc. METHOD FOR PRODUCING L-AMINO ACIDS USING A BACTERIUM BELONGING TO THE FAMILY Enterobacteriaceae HAVING OVEREXPRESSED ydiJ GENE
JP7524909B2 (ja) 2019-04-05 2024-07-30 味の素株式会社 L-アミノ酸の製造方法
JP2022550084A (ja) 2019-09-25 2022-11-30 味の素株式会社 細菌の発酵によるl-アミノ酸の製造方法

Citations (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02109985A (ja) 1988-02-22 1990-04-23 Eurolysine 細菌染色体上ヘの目的遺伝子の組み込み方法及び該方法によって得られた細菌
JPH02207791A (ja) 1989-02-07 1990-08-17 Ajinomoto Co Inc 微生物の形質転換法
JPH04189822A (ja) 1990-11-26 1992-07-08 Showa Highpolymer Co Ltd 脂肪族ポリエステルの製造方法
US5142834A (en) 1990-07-12 1992-09-01 Donnelly Corporation Vehicle trim assembly and fastener therefor
JPH057491A (ja) 1990-10-15 1993-01-19 Ajinomoto Co Inc 温度感受性プラスミド
JPH0568576A (ja) 1991-09-11 1993-03-23 Mitsubishi Petrochem Co Ltd コハク酸の製造法
JPH07107976A (ja) 1993-10-15 1995-04-25 Mitsubishi Chem Corp 挿入配列
US5504004A (en) 1994-12-20 1996-04-02 Michigan Biotechnology Institute Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms
US5521075A (en) 1994-12-19 1996-05-28 Michigan Biotechnology Institute Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants
WO1997016528A1 (en) 1995-11-02 1997-05-09 The University Of Chicago A mutant e. coli strain with increased succinic acid production
WO1998004715A1 (en) 1996-07-30 1998-02-05 Archer-Daniels-Midland Company Novel strains of escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production
JPH11113588A (ja) 1997-10-09 1999-04-27 Mitsubishi Chemical Corp 含酸素化合物の製造方法
JPH11196887A (ja) 1998-01-16 1999-07-27 Mitsubishi Chemical Corp ホスホエノールピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法
JPH11196888A (ja) 1998-01-16 1999-07-27 Mitsubishi Chemical Corp ピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法
WO1999053035A1 (en) 1998-04-13 1999-10-21 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
EP0952221A2 (en) 1998-03-18 1999-10-27 Ajinomoto Co., Ltd. L-Glutamic acid-producing bacterium and method for producing L-glutamic acid
EP0955368A2 (en) 1998-03-18 1999-11-10 Ajinomoto Co., Ltd. L-glutamic acid-producing bacterium and method for producing l-glutamic acid
WO2000018935A1 (fr) 1998-09-25 2000-04-06 Ajinomoto Co.,Inc. Procede de construction d'une bacterie produisant des acides amines, et procede de production d'acides amines par une technique de fermentation utilisant ladite bacterie
US6303383B1 (en) 1999-03-16 2001-10-16 Ajinomoto Co., Inc. Temperature sensitive plasmid for coryneform bacteria
WO2005010175A1 (en) 2003-07-29 2005-02-03 Ajinomoto Co., Inc. Method for producing l-lysine or l-threonine using escherichia bacteria having attnuated malic enzyme activity
JP2005058827A (ja) 2003-08-15 2005-03-10 Asano Koji Kk 有機性汚水の処理方法
WO2005021770A1 (ja) 2003-08-28 2005-03-10 Mitsubishi Chemical Corporation コハク酸の製造方法
WO2005052135A1 (en) 2003-11-27 2005-06-09 Korea Advanced Institute Of Science And Technology Novel rumen bacteria variants and process for preparing succinic acid employing the same
JP2005168401A (ja) 2003-12-11 2005-06-30 Mitsubishi Chemicals Corp 非アミノ有機酸の製造方法
US20050170482A1 (en) 2003-11-14 2005-08-04 Rice University Aerobic succinate production in bacteria
WO2005113745A1 (ja) 2004-05-20 2005-12-01 Ajinomoto Co., Inc. コハク酸生産菌及びコハク酸の製造方法
WO2005113744A1 (ja) 2004-05-20 2005-12-01 Ajinomoto Co., Inc. コハク酸生産菌及びコハク酸の製造方法
WO2005116227A1 (en) 2004-05-03 2005-12-08 Ut-Battelle, Llc A method to produce succinic acid from raw hydrolysates
WO2006031424A2 (en) 2004-08-27 2006-03-23 Rice University Mutant e. coli strain with increased succinic acid production
JP2006180782A (ja) 2004-12-27 2006-07-13 Hiroshima Univ バイオディーゼル廃液からの水素およびエタノールの製造方法、並びに当該方法を行なうためのキット
WO2006107127A1 (en) 2005-04-08 2006-10-12 Korea Advanced Institute Of Science And Technology Method for improving a strain based on in-silico analysis
JP2006320208A (ja) 2005-05-17 2006-11-30 Mitsubishi Chemicals Corp コハク酸の製造方法
WO2007007933A1 (en) 2005-07-11 2007-01-18 Korea Advanced Institute Of Science And Technology Method of in-silico improvement of organisms using the flux sum of metabolites
WO2007037460A1 (en) 2005-09-27 2007-04-05 Ajinomoto Co., Inc. An l-amino acid-producing bacterium and a method for producing l-amino acids

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2036188T3 (es) 1986-06-11 1993-05-16 Michigan Biotechnology Institute Un procedimiento para la produccion de acido succinico por fermentacion anaerobia.
JP2008513023A (ja) * 2004-09-17 2008-05-01 ライス ユニバーシティー 高コハク酸生産細菌
JP4595506B2 (ja) 2004-11-25 2010-12-08 味の素株式会社 L−アミノ酸生産菌及びl−アミノ酸の製造方法
JP2010017081A (ja) 2006-10-10 2010-01-28 Ajinomoto Co Inc L−アミノ酸の製造法
WO2008126896A1 (ja) 2007-04-10 2008-10-23 Ajinomoto Co., Inc. 有機酸の製造方法
WO2008133131A1 (ja) 2007-04-16 2008-11-06 Ajinomoto Co., Inc. 有機酸の製造方法
JP5218400B2 (ja) 2007-04-17 2013-06-26 味の素株式会社 カルボキシル基を有する酸性物質の製造法
JP5644108B2 (ja) 2007-12-06 2014-12-24 味の素株式会社 有機酸の製造方法

Patent Citations (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02109985A (ja) 1988-02-22 1990-04-23 Eurolysine 細菌染色体上ヘの目的遺伝子の組み込み方法及び該方法によって得られた細菌
JPH02207791A (ja) 1989-02-07 1990-08-17 Ajinomoto Co Inc 微生物の形質転換法
US5142834A (en) 1990-07-12 1992-09-01 Donnelly Corporation Vehicle trim assembly and fastener therefor
JPH057491A (ja) 1990-10-15 1993-01-19 Ajinomoto Co Inc 温度感受性プラスミド
JPH04189822A (ja) 1990-11-26 1992-07-08 Showa Highpolymer Co Ltd 脂肪族ポリエステルの製造方法
JPH0568576A (ja) 1991-09-11 1993-03-23 Mitsubishi Petrochem Co Ltd コハク酸の製造法
JPH07107976A (ja) 1993-10-15 1995-04-25 Mitsubishi Chem Corp 挿入配列
US5521075A (en) 1994-12-19 1996-05-28 Michigan Biotechnology Institute Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants
US5504004A (en) 1994-12-20 1996-04-02 Michigan Biotechnology Institute Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms
WO1997016528A1 (en) 1995-11-02 1997-05-09 The University Of Chicago A mutant e. coli strain with increased succinic acid production
US5770435A (en) 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
WO1998004715A1 (en) 1996-07-30 1998-02-05 Archer-Daniels-Midland Company Novel strains of escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production
JPH11113588A (ja) 1997-10-09 1999-04-27 Mitsubishi Chemical Corp 含酸素化合物の製造方法
JPH11196887A (ja) 1998-01-16 1999-07-27 Mitsubishi Chemical Corp ホスホエノールピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法
JPH11196888A (ja) 1998-01-16 1999-07-27 Mitsubishi Chemical Corp ピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法
EP0952221A2 (en) 1998-03-18 1999-10-27 Ajinomoto Co., Ltd. L-Glutamic acid-producing bacterium and method for producing L-glutamic acid
EP0955368A2 (en) 1998-03-18 1999-11-10 Ajinomoto Co., Ltd. L-glutamic acid-producing bacterium and method for producing l-glutamic acid
WO1999053035A1 (en) 1998-04-13 1999-10-21 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
WO2000018935A1 (fr) 1998-09-25 2000-04-06 Ajinomoto Co.,Inc. Procede de construction d'une bacterie produisant des acides amines, et procede de production d'acides amines par une technique de fermentation utilisant ladite bacterie
US6303383B1 (en) 1999-03-16 2001-10-16 Ajinomoto Co., Inc. Temperature sensitive plasmid for coryneform bacteria
WO2005010175A1 (en) 2003-07-29 2005-02-03 Ajinomoto Co., Inc. Method for producing l-lysine or l-threonine using escherichia bacteria having attnuated malic enzyme activity
JP2005058827A (ja) 2003-08-15 2005-03-10 Asano Koji Kk 有機性汚水の処理方法
WO2005021770A1 (ja) 2003-08-28 2005-03-10 Mitsubishi Chemical Corporation コハク酸の製造方法
US20050170482A1 (en) 2003-11-14 2005-08-04 Rice University Aerobic succinate production in bacteria
WO2005052135A1 (en) 2003-11-27 2005-06-09 Korea Advanced Institute Of Science And Technology Novel rumen bacteria variants and process for preparing succinic acid employing the same
US20070054387A1 (en) 2003-11-27 2007-03-08 Lee Sang Y Novel rumen bacteria variants and process for preparing succinic acid employing the same
JP2005168401A (ja) 2003-12-11 2005-06-30 Mitsubishi Chemicals Corp 非アミノ有機酸の製造方法
WO2005116227A1 (en) 2004-05-03 2005-12-08 Ut-Battelle, Llc A method to produce succinic acid from raw hydrolysates
WO2005113744A1 (ja) 2004-05-20 2005-12-01 Ajinomoto Co., Inc. コハク酸生産菌及びコハク酸の製造方法
WO2005113745A1 (ja) 2004-05-20 2005-12-01 Ajinomoto Co., Inc. コハク酸生産菌及びコハク酸の製造方法
WO2006031424A2 (en) 2004-08-27 2006-03-23 Rice University Mutant e. coli strain with increased succinic acid production
JP2006180782A (ja) 2004-12-27 2006-07-13 Hiroshima Univ バイオディーゼル廃液からの水素およびエタノールの製造方法、並びに当該方法を行なうためのキット
WO2006107127A1 (en) 2005-04-08 2006-10-12 Korea Advanced Institute Of Science And Technology Method for improving a strain based on in-silico analysis
JP2006320208A (ja) 2005-05-17 2006-11-30 Mitsubishi Chemicals Corp コハク酸の製造方法
WO2007007933A1 (en) 2005-07-11 2007-01-18 Korea Advanced Institute Of Science And Technology Method of in-silico improvement of organisms using the flux sum of metabolites
WO2007037460A1 (en) 2005-09-27 2007-04-05 Ajinomoto Co., Inc. An l-amino acid-producing bacterium and a method for producing l-amino acids

Non-Patent Citations (60)

* Cited by examiner, † Cited by third party
Title
ALAM, K.Y.; CLARK, D.P., J. BACTERIOL., vol. 171, 1989, pages 6213 - 6217
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 59, 1993, pages 4261 - 4265
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 62, 1996, pages 1808 - 1810
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 63, 1997, pages 2273 - 2280
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 70, 2004, pages 1238 - 1241
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 72, 2006, pages 1939 - 1948
BIBB, M.J.; WARD, J.M.; HOPWOOD, O.A., NATURE, vol. 274, 1978, pages 398
BIOTECHNOL BIOENG., vol. 98, no. 2, 27 March 2007 (2007-03-27), pages 340 - 348
BIOTECHNOL. BIOENG., vol. 74, pages 89 - 95
BIOTECHNOLOGY (NY), vol. 9, no. 1, January 1991 (1991-01-01), pages 84 - 7
CADWELL, R.C., PCR METH. APPL., vol. 2, 1992, pages 28
CHANG, S.; CHOEN, S.N., MOL. GEN. GENET., vol. 168, 1979, pages 111
CHO, E.H.; GUMPORT, R.I.; GARDNER, J.F., J. BACTERIOL., vol. 184, 2002, pages 5200 - 5203
DATSENKO, K.A.; WANNER, B.L., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 6640 - 6645
DONNELLY, M.I.; MILLARD, C.S.; CLARK, D.P.; CHEN, M.J.; RATHKE, J.W., APPL. BIOCHEM. BIOTECHNOL., vol. 70-72, 1998, pages 187 - 198
DUNCAN, C.H.; WILSON, G.A.; YOUNG, F.E., GENE, vol. 1, 1977, pages 153
GENE, vol. 165, 1995, pages 331 - 332
GENE, vol. 191, 1997, pages 47 - 50
GOLDSTEIN ET AL.: "Prokaryotic promoters in biotechnology", BIOTECHNOL. ANNU. REV., vol. 1, 1955, pages 105 - 128, XP008038474
H. SAITO; K. MIURA, BIOCHEM. BIOPHYS. ACTA, vol. 72, 1963, pages 619
HAMILTON ET AL., JOURNAL OF BACTERIOLOGY, vol. 171, pages 4617 - 4622
HINNEN, A.; HICKS, J.B.; FINK, G.R., PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929
INT. J. SYST. BACTERIOL., vol. 39, 1989, pages 337 - 345
INT. J. SYST. BACTERIOL., vol. 43, 1993, pages 162 - 173
INT. J. SYST. BACTERIOL., vol. 43, 1997, pages 1061 - 1067
INT. J. SYST. EVOL. MICROBIOL., vol. 51, May 2001 (2001-05-01), pages 925 - 32
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, vol. 49, 1999, pages 207 - 216
ITO TAKESHI ET AL.: "High-Yield Production of Hydrogen by Enterobacter aerogenes Mutants with Decreased a-Acetolactate Synthase Activity.", J. BIOSCI. BIOENG., vol. 97, no. 4, 2004, pages 227 - 232, XP008136338 *
J. BACTERIOL., vol. 178, 1996, pages 5960 - 5970
J. BIOSCI. BIOENG., vol. 97, no. 4, 2004, pages 227 - 32
J. GEN. APPL. MICROBIOL., vol. 43, 1997, pages 355 - 361
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, 1997, pages 8611 - 8617
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 100, 2005, pages 260 - 265
JOURNAL OF INDUSTRIAL MICROBIOLOGY AND BIOTECHNOLOGY, vol. 28, no. 6, 2002, pages 325 - 332
JUNI, E.J., BIOL. CHEM., vol. 195, 1952, pages 715 - 726
KANAREK, L.; HILL, R.L., J. BIOL. CHEM., vol. 239, 1964, pages 4202
KLOTZSCH, H.R., METH. ENZYMOL., vol. 12, 1969, pages 381 - 386
KNAPPE, J.; BLASCHKOWSKI, H.P., METH. ENZYMOL., vol. 41, 1975, pages 508 - 518
LUTSTORF, U.M.; SCHURCH, P.M.; WARTBURG, J.P., EUR. J. BIOCHEM., vol. 17, 1970, pages 497 - 508
MANDEL, M.; HIGA, A., J. MOL. BIOL., vol. 53, 1970, pages 159
METHODS ENZYMOL., vol. 183, 1990, pages 63
MICROBIOLOGY, vol. 147, 2001, pages 681 - 690
MILLARD, C.S.; CHAO, Y.P.; LIAO, J.C.; DONNELLY, M.I., APPL. ENVIRON. MICROBIOL., vol. 62, 1996, pages 1808 - 1810
MOL. GEN. GENET., vol. 229, 1991, pages 307 - 315
MOL. GEN. GENET., vol. 245, 1994, pages 397 - 405
MOSS, J.; LANE, M.D., ADV. ENZYMOL., vol. 35, 1971, pages 321 - 442
PETERS-WENDISCH, P.G. ET AL., MICROBIOLOGY, vol. 144, 1998, pages 915 - 927
PIL KIM; MARIS LAIVENIEKS; CLAIRE VIEILLE; J. GREGORY ZEIKUS, APPL. ENVIRON. MICROBIOL., vol. 70, 2004, pages 1238 - 1241
PIL, KIM.; MARIS, LAIVENIEKS.; CLAIRE, VIEILLE.; GREGORY, ZEIKUS., APPLIED AND ENVIRONMENTAL MICROBIOLOGY, February 2004 (2004-02-01), pages 1238 - 1241
PLASMID, vol. 44, no. 3, November 2000 (2000-11-01), pages 285 - 91
PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
PROC. NATL. ACAD. SCI. USA, vol. 97, no. 12, 2000, pages 6640 - 6645
PROC. NATL. ACAD. SCI. USA., vol. 90, 1993, pages 1766 - 1779
SANCHEZ A.M. ET AL., BIOTECHNOL. PROG., vol. 21, 2005, pages 358 - 365
SANCHEZ M. AILEN ET AL.: "Efficient Succinic Acid Production from Glucose through Overexpression of Pyruvate Carboxylase in an Escherichia coli Alcohol Dehydrogenase and Lactate Dehydrogenase Mutant.", BIOTECHNOL. PROG., vol. 21, 2005, pages 358 - 365, XP008136355 *
SCIENCE, vol. 277, 1997, pages 1453 - 1474
SKOROKHODOVA, A.Y. ET AL., BIOTEKHNOLOGIYA (RUS), vol. 5, 2004, pages 3 - 21
TEMMER, W.P., NATURE, vol. 370, 1994, pages 389
WHITE, T.J. ET AL., TRENDS GENET., vol. 5, 1989, pages 185
WU HUI ET AL.: "Improved Succinic Acid Production in the Anaerobic Culture of an Escherichia coli pflB ldhA Double Mutant as a Result of Enhanced Anaplerotic Activities in the Preceding Aerobic Culture.", APPL. ENVIRON. MICROBIOL., vol. 73, no. 24, October 2007 (2007-10-01), pages 7837 - 7843, XP008136337 *

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