WO2009041627A1 - 膨潤性架橋ヒアルロン酸粉末及びその製造方法 - Google Patents

膨潤性架橋ヒアルロン酸粉末及びその製造方法 Download PDF

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Publication number
WO2009041627A1
WO2009041627A1 PCT/JP2008/067508 JP2008067508W WO2009041627A1 WO 2009041627 A1 WO2009041627 A1 WO 2009041627A1 JP 2008067508 W JP2008067508 W JP 2008067508W WO 2009041627 A1 WO2009041627 A1 WO 2009041627A1
Authority
WO
WIPO (PCT)
Prior art keywords
hyaluronic acid
acid powder
crosslinked hyaluronic
producing
swellable crosslinked
Prior art date
Application number
PCT/JP2008/067508
Other languages
English (en)
French (fr)
Inventor
Tetsunori Matsumoto
Original Assignee
Shiseido Company Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiseido Company Ltd. filed Critical Shiseido Company Ltd.
Priority to JP2008545106A priority Critical patent/JP4460617B2/ja
Priority to ES08832986T priority patent/ES2381417T3/es
Priority to US12/679,744 priority patent/US8691957B2/en
Priority to AT08832986T priority patent/ATE544786T1/de
Priority to CN2008801093788A priority patent/CN101821294B/zh
Priority to EP08832986A priority patent/EP2199308B1/en
Publication of WO2009041627A1 publication Critical patent/WO2009041627A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

【課題】水中における膨潤性に優れた架橋ヒアルロン酸粉末と、その簡便な製造方法を提供する。 【解決手段】ヒアルロン酸粉末を、炭素数１～４の１価アルコールを含有し、且つ該ヒアルロン酸粉末の溶解度が０．１ｇ／Ｌ未満である液状媒体中に分散した状態で、架橋剤とともに混合し、架橋反応を行なうことを特徴とする膨潤性架橋ヒアルロン酸粉末の製造方法。また、この方法により得られた膨潤性架橋ヒアルロン酸粉末は、水中における膨潤率が５００％以上である。
PCT/JP2008/067508 2007-09-28 2008-09-26 膨潤性架橋ヒアルロン酸粉末及びその製造方法 WO2009041627A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2008545106A JP4460617B2 (ja) 2007-09-28 2008-09-26 膨潤性架橋ヒアルロン酸粉末及びその製造方法
ES08832986T ES2381417T3 (es) 2007-09-28 2008-09-26 Polvo de ácido hialurónico reticulado hinchable y procedimiento para fabricarlo
US12/679,744 US8691957B2 (en) 2007-09-28 2008-09-26 Swellable crosslinked hyaluronan powder and method for producing the same
AT08832986T ATE544786T1 (de) 2007-09-28 2008-09-26 Quellbares vernetztes hyaluronsäurepulver und herstellungsverfahren dafür
CN2008801093788A CN101821294B (zh) 2007-09-28 2008-09-26 溶胀性交联透明质酸粉末及其制造方法
EP08832986A EP2199308B1 (en) 2007-09-28 2008-09-26 Swellable crosslinked hyaluronic acid powder and method for producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-253639 2007-09-28
JP2007253639 2007-09-28

Publications (1)

Publication Number Publication Date
WO2009041627A1 true WO2009041627A1 (ja) 2009-04-02

Family

ID=40511507

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/067508 WO2009041627A1 (ja) 2007-09-28 2008-09-26 膨潤性架橋ヒアルロン酸粉末及びその製造方法

Country Status (8)

Country Link
US (1) US8691957B2 (ja)
EP (1) EP2199308B1 (ja)
JP (1) JP4460617B2 (ja)
KR (1) KR100990301B1 (ja)
CN (1) CN101821294B (ja)
AT (1) ATE544786T1 (ja)
ES (1) ES2381417T3 (ja)
WO (1) WO2009041627A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013502941A (ja) * 2009-08-27 2013-01-31 フィディア ファーマチェウティチ ソシエタ ペル アチオニ 新規な充填剤としての粘弾性ゲル
JP2021021082A (ja) * 2016-01-29 2021-02-18 ハンミ ファーマシューティカルズ カンパニー リミテッド 複合ヒアルロン酸架橋物及びその製造方法
US11097086B2 (en) 2014-11-14 2021-08-24 L'oreal Micro-needle sheet for reducing wrinkles

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CN102120833A (zh) * 2011-01-10 2011-07-13 深圳市资福药业有限公司 一种透明质酸盐凝胶颗粒及其制备方法
JP5779249B2 (ja) * 2011-08-02 2015-09-16 大日精化工業株式会社 癒着防止用医用材料及びその製造方法
WO2014206500A1 (en) * 2013-06-28 2014-12-31 Galderma S.A. Method for manufacturing a shaped cross-linked hyaluronic acid product
CN105163716B (zh) * 2013-07-03 2019-02-12 株式会社利他药业 水溶性透明质酸凝胶及其制造方法
KR102275105B1 (ko) * 2013-09-09 2021-07-09 주식회사 휴메딕스 고밀도 망상구조로 가교된 히알루론산 및 그의 제조방법
AU2014352672B2 (en) * 2013-11-25 2018-11-29 Deuteria Biomaterials, Llc Deuterium-enriched hyaluronan
CN104761735B (zh) * 2014-01-08 2017-07-25 上海其胜生物制剂有限公司 一种具有抑制透明质酸酶活性的交联透明质酸钠凝胶的制备方法
CN105670011B (zh) * 2016-02-02 2019-01-08 华熙福瑞达生物医药有限公司 一种交联透明质酸干粉及其制备方法及应用
KR20220095126A (ko) 2020-12-29 2022-07-06 (주)아모레퍼시픽 물리적으로 가교된 고분자 히알루론산 또는 그 염을 포함하는 겔 조성물 및 키트
KR102380762B1 (ko) * 2021-01-11 2022-03-30 조광용 온도감응성 히알루론산 비드 겔
CN113861444A (zh) * 2021-09-13 2021-12-31 北京思尔根生物科技有限公司 一种非均相交联透明质酸钠凝胶的制备方法
KR20230041421A (ko) 2021-09-17 2023-03-24 (주)아모레퍼시픽 물리적으로 가교된 고분자 히알루론산 또는 그 염을 포함하는 조성물

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JPS60130601A (ja) 1983-12-15 1985-07-12 バイオマトリツクス，インコ−ポレイテツド ヒアルロン酸水不溶性組成物の製法
JPS61164558A (ja) * 1985-01-17 1986-07-25 生化学工業株式会社 医療用成形物の成形材料
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JPH08333402A (ja) * 1995-06-07 1996-12-17 Gunze Ltd 架橋多糖類及びその製造法並びにこれによる複合材料
JP3094074B2 (ja) 1995-07-17 2000-10-03 キユー・メド・アクチエボラーグ 多糖ゲル組成物
JP2001348401A (ja) * 2000-06-06 2001-12-18 National Institute Of Advanced Industrial & Technology ヒアルロン酸架橋化物

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JPS60130601A (ja) 1983-12-15 1985-07-12 バイオマトリツクス，インコ−ポレイテツド ヒアルロン酸水不溶性組成物の製法
JPS61164558A (ja) * 1985-01-17 1986-07-25 生化学工業株式会社 医療用成形物の成形材料
JPH07102002A (ja) * 1993-09-30 1995-04-18 Gunze Ltd 架橋ヒアルロン酸及びこれらの複合材料
JPH08333402A (ja) * 1995-06-07 1996-12-17 Gunze Ltd 架橋多糖類及びその製造法並びにこれによる複合材料
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JP2001348401A (ja) * 2000-06-06 2001-12-18 National Institute Of Advanced Industrial & Technology ヒアルロン酸架橋化物

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013502941A (ja) * 2009-08-27 2013-01-31 フィディア ファーマチェウティチ ソシエタ ペル アチオニ 新規な充填剤としての粘弾性ゲル
EP2470230B2 (en) † 2009-08-27 2022-07-06 Fidia Farmaceutici S.p.A. Viscoelastic gels as novel fillers
US11097086B2 (en) 2014-11-14 2021-08-24 L'oreal Micro-needle sheet for reducing wrinkles
JP2021021082A (ja) * 2016-01-29 2021-02-18 ハンミ ファーマシューティカルズ カンパニー リミテッド 複合ヒアルロン酸架橋物及びその製造方法

Also Published As

Publication number Publication date
EP2199308A1 (en) 2010-06-23
CN101821294A (zh) 2010-09-01
EP2199308A4 (en) 2011-02-23
KR20100058607A (ko) 2010-06-03
EP2199308B1 (en) 2012-02-08
ATE544786T1 (de) 2012-02-15
US8691957B2 (en) 2014-04-08
ES2381417T3 (es) 2012-05-28
JPWO2009041627A1 (ja) 2011-01-27
KR100990301B1 (ko) 2010-10-26
CN101821294B (zh) 2012-10-31
US20100210587A1 (en) 2010-08-19
JP4460617B2 (ja) 2010-05-12

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