WO2009034949A1 - 体液浄化処理用吸着カラム - Google Patents
体液浄化処理用吸着カラム Download PDFInfo
- Publication number
- WO2009034949A1 WO2009034949A1 PCT/JP2008/066179 JP2008066179W WO2009034949A1 WO 2009034949 A1 WO2009034949 A1 WO 2009034949A1 JP 2008066179 W JP2008066179 W JP 2008066179W WO 2009034949 A1 WO2009034949 A1 WO 2009034949A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- body fluid
- skeleton
- adsorbed
- subject
- adsorption column
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
- B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28078—Pore diameter
- B01J20/2808—Pore diameter being less than 2 nm, i.e. micropores or nanopores
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28078—Pore diameter
- B01J20/28083—Pore diameter being in the range 2-50 nm, i.e. mesopores
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28078—Pore diameter
- B01J20/28085—Pore diameter being more than 50 nm, i.e. macropores
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28095—Shape or type of pores, voids, channels, ducts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3204—Inorganic carriers, supports or substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/327—Polymers obtained by reactions involving only carbon to carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
- B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/328—Polymers on the carrier being further modified
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/58—Use in a single column
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Inorganic Chemistry (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- External Artificial Organs (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
吸着対象物質の飽和吸着量を増大或いは飽和吸着に至るまでの時間を短縮可能で、カラム容量を大幅に低減可能で治療時間の大幅な短縮が可能な体液浄化処理用の吸着カラムを提供する。少なくとも低密度リポタンパクを含む吸着対象物質に特異的に結合する官能基6を多孔質担体5の表面に固定してなる体液浄化処理用の吸着カラムであって、多孔質担体5が、3次元網目構造のシリカゲルまたはシリカガラスからなる骨格体7と、骨格体の間隙に形成された水銀圧入法で測定した平均孔径が1μm以上4μm未満の範囲内の3次元網目状の貫通孔8を有し、且つ、水銀圧入法で測定した平均孔径が吸着対象物質の粒径より大きい細孔9を骨格体の表面に分散して有する2重細孔構造を備える。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/677,955 US20100276359A1 (en) | 2007-09-12 | 2008-09-08 | Adsorption column for purifying body fluid |
EP08830859A EP2198901B1 (en) | 2007-09-12 | 2008-09-08 | Adsorption column for purifying body fluid |
AT08830859T ATE538822T1 (de) | 2007-09-12 | 2008-09-08 | Adsorptionssäule zur reinigung von körperflüssigkeiten |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007236564A JP4226050B1 (ja) | 2007-09-12 | 2007-09-12 | 体液浄化処理用吸着カラム |
JP2007-236564 | 2007-09-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009034949A1 true WO2009034949A1 (ja) | 2009-03-19 |
Family
ID=40445087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/066179 WO2009034949A1 (ja) | 2007-09-12 | 2008-09-08 | 体液浄化処理用吸着カラム |
Country Status (5)
Country | Link |
---|---|
US (1) | US20100276359A1 (ja) |
EP (1) | EP2198901B1 (ja) |
JP (1) | JP4226050B1 (ja) |
AT (1) | ATE538822T1 (ja) |
WO (1) | WO2009034949A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015000113A (ja) * | 2013-06-13 | 2015-01-05 | サンデン商事株式会社 | 環状多糖類を用いた血中の脂質除去システム |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101370536A (zh) | 2005-12-13 | 2009-02-18 | 埃克塞拉有限责任公司 | 用于从血液中体外去除病原微生物、炎性细胞或炎性蛋白质的方法 |
WO2008155683A1 (en) | 2007-06-18 | 2008-12-24 | Firmenich Sa | Malodor counteracting compositions and method for their use |
JP5308171B2 (ja) * | 2009-01-20 | 2013-10-09 | 株式会社ルネッサンス・エナジー・インベストメント | 体液浄化処理用吸着カラム |
KR101876794B1 (ko) | 2009-12-01 | 2018-07-10 | 엑스테라 메디컬 코퍼레이션 | 표면 고정화된 다당류를 이용하여 혈액으로부터 사이토카인을 제거하는 방법 |
WO2012112724A1 (en) | 2011-02-15 | 2012-08-23 | Exthera Medical, Llc | Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines |
DK2861273T3 (da) | 2012-06-13 | 2017-11-27 | Exthera Medical Corp | Anvendelse af heparin og kulhydrater til behandling af cancer. |
CN105339067A (zh) | 2013-06-24 | 2016-02-17 | 艾克塞拉医疗公司 | 含有涂覆甘露糖的基质的血液过滤系统 |
AU2014346668C1 (en) | 2013-11-08 | 2018-04-26 | Exthera Medical Corporation | Methods for diagnosing infectious diseases using adsorption media |
US11680080B2 (en) | 2014-03-13 | 2023-06-20 | Folim G. Halaka | Purification columns and methods |
EP3117208A4 (en) * | 2014-03-13 | 2018-01-24 | Folim G. Halaka | Purification columns and methods |
JP2017513636A (ja) | 2014-04-24 | 2017-06-01 | エクスセラ メディカル コーポレイション | 高流量を用いて血液から細菌を除去するための方法 |
CA2959975A1 (en) | 2014-09-22 | 2016-03-31 | Exthera Medical Corporation | Wearable hemoperfusion device |
US11911551B2 (en) | 2016-03-02 | 2024-02-27 | Exthera Medical Corporation | Method for treating drug intoxication |
EP3422943A4 (en) | 2016-03-02 | 2019-10-16 | ExThera Medical Corporation | METHOD OF TREATING DRUG ENTRIES |
Citations (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5826819A (ja) * | 1982-03-17 | 1983-02-17 | Kuraray Co Ltd | 多孔性ガラスからなる低密度リポ蛋白質吸着剤 |
JPS60241450A (ja) * | 1984-05-16 | 1985-11-30 | 旭化成株式会社 | 体液浄化用吸着材 |
US4637994A (en) | 1982-12-02 | 1987-01-20 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Adsorbent and process for preparing the same |
JPS62224362A (ja) * | 1986-03-27 | 1987-10-02 | 鐘淵化学工業株式会社 | 保存安定性の改良された体外循環治療用吸着カラム |
JPS62224363A (ja) * | 1986-03-27 | 1987-10-02 | 鐘淵化学工業株式会社 | 吸着体の滅菌方法 |
JPH0258939B2 (ja) * | 1983-04-22 | 1990-12-11 | Kanegafuchi Chemical Ind | |
JPH038729A (ja) * | 1988-09-28 | 1991-01-16 | Soga Naohiro | 多孔質ガラスの製造法 |
JPH0339736B2 (ja) | 1983-02-25 | 1991-06-14 | Kanegafuchi Chemical Ind | |
JPH03254756A (ja) * | 1989-10-03 | 1991-11-13 | Fresenius Ag | 体外循環全血液からldlおよび内毒素のような生物巨大分子を除去するための吸着剤 |
JPH0611322B2 (ja) * | 1987-02-25 | 1994-02-16 | 鐘淵化学工業株式会社 | リポ蛋白吸着体およびそれを用いたリポ蛋白除去装置 |
JPH0741374A (ja) | 1993-07-30 | 1995-02-10 | Naohiro Soga | 無機系多孔質体の製造方法 |
JPH07198705A (ja) * | 1993-12-28 | 1995-08-01 | Shimadzu Corp | 無機系多孔質プレート |
JPH0812346A (ja) * | 1994-07-05 | 1996-01-16 | Agency Of Ind Science & Technol | 連結シリカ球状粒子からなる三次元網状構造体と樹脂とによる相互貫入型複合体およびその製造方法 |
JPH0812317A (ja) * | 1994-06-27 | 1996-01-16 | Agency Of Ind Science & Technol | シリカ球状粒子からなる三次元網状構造体 |
JPH0852303A (ja) * | 1995-05-23 | 1996-02-27 | Kanegafuchi Chem Ind Co Ltd | 体外循環治療用吸着カラムの保存安定性を改良する方法 |
JPH10182261A (ja) * | 1996-12-26 | 1998-07-07 | Naohiro Soga | 無機系多孔質体の製造方法 |
JP2925249B2 (ja) * | 1990-06-08 | 1999-07-28 | 鐘淵化学工業株式会社 | コレステロールの除去方法 |
JP3254756B2 (ja) | 1992-10-13 | 2002-02-12 | 株式会社日立製作所 | 電子装置 |
JP2004099418A (ja) * | 2002-09-13 | 2004-04-02 | Naohiro Soga | 一体型多孔質材料の製造方法 |
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EP1357383B1 (en) * | 2002-04-09 | 2005-11-09 | Cholestech Corporation | High-density lipoprotein assay device and method |
GB2389322B (en) * | 2002-06-07 | 2005-08-17 | Baldwin Filters Inc | Environmentally friendly dual lube venturi filter cartridge |
EP1542926A1 (en) * | 2002-08-23 | 2005-06-22 | McMaster University | Methods and compounds for controlling the morphology and shrinkage of silica derived from polyol-modified silanes |
-
2007
- 2007-09-12 JP JP2007236564A patent/JP4226050B1/ja not_active Expired - Fee Related
-
2008
- 2008-09-08 WO PCT/JP2008/066179 patent/WO2009034949A1/ja active Application Filing
- 2008-09-08 AT AT08830859T patent/ATE538822T1/de active
- 2008-09-08 US US12/677,955 patent/US20100276359A1/en not_active Abandoned
- 2008-09-08 EP EP08830859A patent/EP2198901B1/en not_active Not-in-force
Patent Citations (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5826819A (ja) * | 1982-03-17 | 1983-02-17 | Kuraray Co Ltd | 多孔性ガラスからなる低密度リポ蛋白質吸着剤 |
US4637994A (en) | 1982-12-02 | 1987-01-20 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Adsorbent and process for preparing the same |
JPH0339736B2 (ja) | 1983-02-25 | 1991-06-14 | Kanegafuchi Chemical Ind | |
JPH0258939B2 (ja) * | 1983-04-22 | 1990-12-11 | Kanegafuchi Chemical Ind | |
JPS60241450A (ja) * | 1984-05-16 | 1985-11-30 | 旭化成株式会社 | 体液浄化用吸着材 |
JPS62224362A (ja) * | 1986-03-27 | 1987-10-02 | 鐘淵化学工業株式会社 | 保存安定性の改良された体外循環治療用吸着カラム |
JPS62224363A (ja) * | 1986-03-27 | 1987-10-02 | 鐘淵化学工業株式会社 | 吸着体の滅菌方法 |
JPH0611322B2 (ja) * | 1987-02-25 | 1994-02-16 | 鐘淵化学工業株式会社 | リポ蛋白吸着体およびそれを用いたリポ蛋白除去装置 |
JPH038729A (ja) * | 1988-09-28 | 1991-01-16 | Soga Naohiro | 多孔質ガラスの製造法 |
JPH03254756A (ja) * | 1989-10-03 | 1991-11-13 | Fresenius Ag | 体外循環全血液からldlおよび内毒素のような生物巨大分子を除去するための吸着剤 |
JP3100974B2 (ja) * | 1989-10-03 | 2000-10-23 | フレセニウス アーゲー | 体外循環全血液からldlおよび内毒素のような生物巨大分子を除去するための吸着剤 |
JP2925249B2 (ja) * | 1990-06-08 | 1999-07-28 | 鐘淵化学工業株式会社 | コレステロールの除去方法 |
JP3254756B2 (ja) | 1992-10-13 | 2002-02-12 | 株式会社日立製作所 | 電子装置 |
JPH0741374A (ja) | 1993-07-30 | 1995-02-10 | Naohiro Soga | 無機系多孔質体の製造方法 |
JPH07198705A (ja) * | 1993-12-28 | 1995-08-01 | Shimadzu Corp | 無機系多孔質プレート |
JPH0812317A (ja) * | 1994-06-27 | 1996-01-16 | Agency Of Ind Science & Technol | シリカ球状粒子からなる三次元網状構造体 |
JPH0812346A (ja) * | 1994-07-05 | 1996-01-16 | Agency Of Ind Science & Technol | 連結シリカ球状粒子からなる三次元網状構造体と樹脂とによる相互貫入型複合体およびその製造方法 |
JPH0852303A (ja) * | 1995-05-23 | 1996-02-27 | Kanegafuchi Chem Ind Co Ltd | 体外循環治療用吸着カラムの保存安定性を改良する方法 |
JPH10182261A (ja) * | 1996-12-26 | 1998-07-07 | Naohiro Soga | 無機系多孔質体の製造方法 |
JP2004099418A (ja) * | 2002-09-13 | 2004-04-02 | Naohiro Soga | 一体型多孔質材料の製造方法 |
Non-Patent Citations (1)
Title |
---|
NOBUTAKA TANI: "Development of Blood Adsorption Device", JAPANESE JOURNAL OF MEDICAL INSTRUMENTATION, vol. 58, no. 6, 1988, pages 266 - 273 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015000113A (ja) * | 2013-06-13 | 2015-01-05 | サンデン商事株式会社 | 環状多糖類を用いた血中の脂質除去システム |
Also Published As
Publication number | Publication date |
---|---|
ATE538822T1 (de) | 2012-01-15 |
EP2198901A1 (en) | 2010-06-23 |
JP4226050B1 (ja) | 2009-02-18 |
EP2198901A4 (en) | 2011-05-11 |
JP2009066117A (ja) | 2009-04-02 |
EP2198901B1 (en) | 2011-12-28 |
US20100276359A1 (en) | 2010-11-04 |
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