WO2009028136A1 - 蛍光観察装置 - Google Patents

蛍光観察装置 Download PDF

Info

Publication number
WO2009028136A1
WO2009028136A1 PCT/JP2008/002091 JP2008002091W WO2009028136A1 WO 2009028136 A1 WO2009028136 A1 WO 2009028136A1 JP 2008002091 W JP2008002091 W JP 2008002091W WO 2009028136 A1 WO2009028136 A1 WO 2009028136A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
fluorescence
component
image
infrared ray
Prior art date
Application number
PCT/JP2008/002091
Other languages
English (en)
French (fr)
Inventor
Jiro Minehisa
Original Assignee
Panasonic Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panasonic Corporation filed Critical Panasonic Corporation
Priority to JP2009529968A priority Critical patent/JPWO2009028136A1/ja
Publication of WO2009028136A1 publication Critical patent/WO2009028136A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4887—Locating particular structures in or on the body
    • A61B5/489—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

　本発明は、血液中に含まれる光感受性物質からの蛍光の影響を除去して、病変領域の位置や範囲をより正確に特定できる蛍光観察装置に関する。蛍光観察装置は、可視照明光を照射する照明光源と、励起光を照射する励起光源と、赤外光を照射する赤外光源と、観察領域からの反射光を可視光成分および蛍光成分を含む第一の分離光と赤外光成分を含む第二の分離光とに分離する光分離手段と、第一の分離光から励起光成分を除去する励起光除去手段と、励起光成分を除去された第一の分離光を撮像する第一の撮像手段と、第二の分離光を撮像する第二の撮像手段と、第一の撮像手段および第二の撮像手段により撮像された画像を一の画像に合成する画像合成手段とを有する。蛍光観察装置は、赤外光像から血管の位置を特定し、可視光蛍光像から血液中の光感受性物質由来の蛍光成分を除去することで、病変領域の位置や範囲を正確に特定する。
PCT/JP2008/002091 2007-08-29 2008-08-01 蛍光観察装置 WO2009028136A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009529968A JPWO2009028136A1 (ja) 2007-08-29 2008-08-01 蛍光観察装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-223084 2007-08-29
JP2007223084 2007-08-29

Publications (1)

Publication Number Publication Date
WO2009028136A1 true WO2009028136A1 (ja) 2009-03-05

Family

ID=40386879

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/002091 WO2009028136A1 (ja) 2007-08-29 2008-08-01 蛍光観察装置

Country Status (2)

Country Link
JP (1) JPWO2009028136A1 (ja)
WO (1) WO2009028136A1 (ja)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011048886A1 (ja) * 2009-10-20 2011-04-28 オリンパスメディカルシステムズ株式会社 蛍光観察装置
JP2013514156A (ja) * 2009-12-15 2013-04-25 エモリー ユニバーシティ 診断又は治療処置においてリアルタイム解剖学的指針を提供するシステム及び方法
CN103284694A (zh) * 2013-05-22 2013-09-11 西安电子科技大学 一种活体动物血管新生定量分析方法
CN104287689A (zh) * 2014-09-28 2015-01-21 安徽中科医药成像技术科技有限公司 内窥镜及其调节装置
JP2015091351A (ja) * 2014-12-24 2015-05-14 富士フイルム株式会社 内視鏡装置
JP2015129713A (ja) * 2014-01-08 2015-07-16 オリンパス株式会社 画像取得装置および方法
JP2015527909A (ja) * 2012-07-10 2015-09-24 アイマゴ ソシエテ アノニムＡｉｍａｇｏ Ｓ．Ａ． 灌流評価マルチモダリティ光学医用デバイス
US9345389B2 (en) 2010-11-12 2016-05-24 Emory University Additional systems and methods for providing real-time anatomical guidance in a diagnostic or therapeutic procedure
JP2016214507A (ja) * 2015-05-19 2016-12-22 株式会社島津製作所 イメージング装置
CN106943193A (zh) * 2017-04-27 2017-07-14 华中科技大学 共定位手术导航系统和相机头
US9757039B2 (en) 2008-07-10 2017-09-12 Ecole Polytechnique Federale De Lausanne (Epfl) Functional optical coherent imaging
JP2017176811A (ja) * 2016-03-28 2017-10-05 ソニー株式会社 撮像装置、撮像方法及び医療用観察機器
CN107374730A (zh) * 2017-09-06 2017-11-24 东北大学 光学手术导航系统
JP2018201648A (ja) * 2017-05-31 2018-12-27 三菱電機エンジニアリング株式会社 撮像装置
US10169862B2 (en) 2015-05-07 2019-01-01 Novadaq Technologies ULC Methods and systems for laser speckle imaging of tissue using a color image sensor
EP3332689A4 (en) * 2015-08-03 2019-05-08 National Cancer Center PEN TYPE MEDICAL FLUORESCENT IMAGING DEVICE AND SYSTEM FOR ALIGNING MULTIPLE FLUORESCENT IMAGES USING THE SAME
WO2019215799A1 (ja) * 2018-05-07 2019-11-14 株式会社島津製作所 医療用イメージング装置
US10575737B2 (en) 2012-04-27 2020-03-03 Novadaq Technologies ULC Optical coherent imaging medical device
CN110868914A (zh) * 2017-07-11 2020-03-06 高露洁-棕榄公司 口腔护理评估系统和方法
JPWO2018216658A1 (ja) * 2017-05-23 2020-03-26 国立研究開発法人産業技術総合研究所 撮像装置、撮像システム、及び撮像方法
JP2020046208A (ja) * 2018-09-14 2020-03-26 株式会社東芝 光学センサ
JPWO2021038734A1 (ja) * 2019-08-27 2021-03-04
JP2021192534A (ja) * 2017-03-23 2021-12-16 株式会社Ｊｖｃケンウッド 撮像装置及び撮像方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017203448B9 (de) * 2017-03-02 2021-12-23 Carl Zeiss Meditec Ag Mikroskopiesystem und Mikroskopieverfahren zum Quantifizieren einer Fluoreszenz

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07222712A (ja) * 1994-02-10 1995-08-22 Olympus Optical Co Ltd 蛍光内視鏡装置
JPH09294706A (ja) * 1996-04-30 1997-11-18 Fuji Photo Film Co Ltd 蛍光診断装置
JP2003153850A (ja) * 2001-11-22 2003-05-27 Olympus Optical Co Ltd 内視鏡用撮像装置
JP2007143647A (ja) * 2005-11-24 2007-06-14 Olympus Medical Systems Corp 電子内視鏡装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3560671B2 (ja) * 1995-02-23 2004-09-02 オリンパス株式会社 蛍光観察装置
JP3525235B2 (ja) * 1995-12-06 2004-05-10 松下電器産業株式会社 光診断装置
JP2738390B2 (ja) * 1996-06-21 1998-04-08 松下電器産業株式会社 診断・治療装置
JP3962122B2 (ja) * 1996-11-20 2007-08-22 オリンパス株式会社 内視鏡装置
US6826424B1 (en) * 2000-12-19 2004-11-30 Haishan Zeng Methods and apparatus for fluorescence and reflectance imaging and spectroscopy and for contemporaneous measurements of electromagnetic radiation with multiple measuring devices
JP2004024656A (ja) * 2002-06-27 2004-01-29 Fuji Photo Film Co Ltd 蛍光内視鏡装置
JP4258324B2 (ja) * 2003-09-08 2009-04-30 パナソニック株式会社 医療用光源システム
JP2005131129A (ja) * 2003-10-30 2005-05-26 Olympus Corp 撮像装置及び内視鏡装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07222712A (ja) * 1994-02-10 1995-08-22 Olympus Optical Co Ltd 蛍光内視鏡装置
JPH09294706A (ja) * 1996-04-30 1997-11-18 Fuji Photo Film Co Ltd 蛍光診断装置
JP2003153850A (ja) * 2001-11-22 2003-05-27 Olympus Optical Co Ltd 内視鏡用撮像装置
JP2007143647A (ja) * 2005-11-24 2007-06-14 Olympus Medical Systems Corp 電子内視鏡装置

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9757039B2 (en) 2008-07-10 2017-09-12 Ecole Polytechnique Federale De Lausanne (Epfl) Functional optical coherent imaging
US10617303B2 (en) 2008-07-10 2020-04-14 Ecole Polytechnique Federale De Lausanne (Epfl) Functional optical coherent imaging
WO2011048886A1 (ja) * 2009-10-20 2011-04-28 オリンパスメディカルシステムズ株式会社 蛍光観察装置
JPWO2011048886A1 (ja) * 2009-10-20 2013-03-07 オリンパスメディカルシステムズ株式会社 蛍光観察装置
JP2013514156A (ja) * 2009-12-15 2013-04-25 エモリー ユニバーシティ 診断又は治療処置においてリアルタイム解剖学的指針を提供するシステム及び方法
US9451882B2 (en) 2009-12-15 2016-09-27 Emory University Integrated system and methods for real-time anatomical guidance in a diagnostic or therapeutic procedure
US9345389B2 (en) 2010-11-12 2016-05-24 Emory University Additional systems and methods for providing real-time anatomical guidance in a diagnostic or therapeutic procedure
US10575737B2 (en) 2012-04-27 2020-03-03 Novadaq Technologies ULC Optical coherent imaging medical device
US10101571B2 (en) 2012-07-10 2018-10-16 Novadaq Technologies ULC Perfusion assessment multi-modality optical medical device
JP2015527909A (ja) * 2012-07-10 2015-09-24 アイマゴ ソシエテ アノニムＡｉｍａｇｏ Ｓ．Ａ． 灌流評価マルチモダリティ光学医用デバイス
CN103284694A (zh) * 2013-05-22 2013-09-11 西安电子科技大学 一种活体动物血管新生定量分析方法
JP2015129713A (ja) * 2014-01-08 2015-07-16 オリンパス株式会社 画像取得装置および方法
CN104287689A (zh) * 2014-09-28 2015-01-21 安徽中科医药成像技术科技有限公司 内窥镜及其调节装置
JP2015091351A (ja) * 2014-12-24 2015-05-14 富士フイルム株式会社 内視鏡装置
US10169862B2 (en) 2015-05-07 2019-01-01 Novadaq Technologies ULC Methods and systems for laser speckle imaging of tissue using a color image sensor
JP2016214507A (ja) * 2015-05-19 2016-12-22 株式会社島津製作所 イメージング装置
EP3332689A4 (en) * 2015-08-03 2019-05-08 National Cancer Center PEN TYPE MEDICAL FLUORESCENT IMAGING DEVICE AND SYSTEM FOR ALIGNING MULTIPLE FLUORESCENT IMAGES USING THE SAME
JP2017176811A (ja) * 2016-03-28 2017-10-05 ソニー株式会社 撮像装置、撮像方法及び医療用観察機器
JP7314976B2 (ja) 2017-03-23 2023-07-26 株式会社Ｊｖｃケンウッド 撮像装置及び撮像方法
JP2021192534A (ja) * 2017-03-23 2021-12-16 株式会社Ｊｖｃケンウッド 撮像装置及び撮像方法
CN106943193A (zh) * 2017-04-27 2017-07-14 华中科技大学 共定位手术导航系统和相机头
JPWO2018216658A1 (ja) * 2017-05-23 2020-03-26 国立研究開発法人産業技術総合研究所 撮像装置、撮像システム、及び撮像方法
JP2018201648A (ja) * 2017-05-31 2018-12-27 三菱電機エンジニアリング株式会社 撮像装置
CN110868914A (zh) * 2017-07-11 2020-03-06 高露洁-棕榄公司 口腔护理评估系统和方法
CN107374730A (zh) * 2017-09-06 2017-11-24 东北大学 光学手术导航系统
JPWO2019215799A1 (ja) * 2018-05-07 2021-03-11 株式会社島津製作所 医療用イメージング装置
WO2019215799A1 (ja) * 2018-05-07 2019-11-14 株式会社島津製作所 医療用イメージング装置
JP2020046208A (ja) * 2018-09-14 2020-03-26 株式会社東芝 光学センサ
US10837905B2 (en) 2018-09-14 2020-11-17 Kabushiki Kaisha Toshiba Optical sensor
JPWO2021038734A1 (ja) * 2019-08-27 2021-03-04

Also Published As

Publication number Publication date
JPWO2009028136A1 (ja) 2010-11-25

Similar Documents

Publication Publication Date Title
WO2009028136A1 (ja) 蛍光観察装置
WO2010045949A3 (en) Apparatus and methods for analysing fluorescent particles
EP3318865A1 (en) Fluorescent microscopic imaging method and apparatus
WO2004054439A3 (en) Optical examination method and apparatus particularly useful for real-time discrimination of tumors from normal tissues during surgery
WO2007099525A3 (en) System and method of automatic prioritization and analysis of medical images
EP2557001A3 (en) Detection apparatus and method
WO2005089637A3 (en) Method and system for tomographic imaging using fluorescent proteins
EP1669019A3 (en) Fluorescence endoscopy device
WO2008100895A3 (en) Universal multidetection system for microplates
WO2008088002A1 (ja) 蛍光観察装置および蛍光観察方法
WO2009067622A8 (en) Automated systems and assemblies for use in evaluating agricultural products and methods therefor
EP1855102B8 (en) Fluorescence detecting device and fluorescence detecting method
WO2007137124A3 (en) Devices and methods for fluorescent inspection and/or removal of material in a sample
WO2008093746A1 (ja) 蛍光観察装置および蛍光観察方法
EP2402734A3 (en) Minute particle analyzing device and method
WO2012123881A3 (en) Medical instrument for examining the cervix
ES2528321T3 (es) Detección de a-fucosilación en anticuerpos
WO2009064979A3 (en) Method and apparatus for processing a pulsatile biometric signal
WO2008019936A3 (en) Microlithographic projection exposure apparatus and microlithographic exposure method
WO2010083204A3 (en) Noninvasive measurement of flavonoid compounds in biological tissue
WO2012008836A3 (en) Inspection apparatus and replaceable door for a vacuum chamber of such an inspection apparatus and a method for operating an inspection apparatus
WO2007021809A3 (en) Microfluidic systems, devices and methods for reducing background autofluorescence and the effects thereof
EP1760454A4 (en) PHOTOMETRIC FLUORESCENT METHOD
ATE506627T1 (de) Verfahren und vorrichtung zur optischen gewebeanalyse
EP3175767A1 (en) Control device and endoscope system

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref document number: 2009529968

Country of ref document: JP

Kind code of ref document: A

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08790355

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08790355

Country of ref document: EP

Kind code of ref document: A1