WO2008088002A1 - 蛍光観察装置および蛍光観察方法 - Google Patents

蛍光観察装置および蛍光観察方法 Download PDF

Info

Publication number
WO2008088002A1
WO2008088002A1 PCT/JP2008/050489 JP2008050489W WO2008088002A1 WO 2008088002 A1 WO2008088002 A1 WO 2008088002A1 JP 2008050489 W JP2008050489 W JP 2008050489W WO 2008088002 A1 WO2008088002 A1 WO 2008088002A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
fluorescence
image
region
exciting
Prior art date
Application number
PCT/JP2008/050489
Other languages
English (en)
French (fr)
Inventor
Yasushige Ishihara
Original Assignee
Olympus Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Corporation filed Critical Olympus Corporation
Priority to US12/522,601 priority Critical patent/US8049184B2/en
Priority to EP08703349.4A priority patent/EP2105082B1/en
Priority to CN2008800022249A priority patent/CN101583304B/zh
Publication of WO2008088002A1 publication Critical patent/WO2008088002A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4887—Locating particular structures in or on the body
    • A61B5/489—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0646—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements with illumination filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0655—Control therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Vascular Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Endoscopes (AREA)

Abstract

　取得された蛍光画像中において病変部を際立たせることができ、正確な診断を行うことを可能とする。血管により吸収される波長帯域の照明光と、病変部に特異的に集積する蛍光色素を励起して薬剤蛍光を発生させる励起光とを観察対象部位（Ｓ）に照射する光源部（２）と、同一の観察対象部位（Ｓ）に対し、前記照明光および前記励起光を照射して得られた反射光および蛍光をそれぞれ撮影して画像を取得する撮像部（１５，１６）と、該撮像部（１５，１６）により取得された反射光画像の輝度を平滑化して参照画像を取得し、取得された参照画像に基づいて前記蛍光画像を補正する画像処理部（４）とを備える蛍光観察装置（１）を提供する。
PCT/JP2008/050489 2007-01-18 2008-01-17 蛍光観察装置および蛍光観察方法 WO2008088002A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/522,601 US8049184B2 (en) 2007-01-18 2008-01-17 Fluoroscopic device and fluoroscopic method
EP08703349.4A EP2105082B1 (en) 2007-01-18 2008-01-17 Fluorescence observing device and fluorescence observing method
CN2008800022249A CN101583304B (zh) 2007-01-18 2008-01-17 荧光观察装置和荧光观察方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-009284 2007-01-18
JP2007009284A JP5074044B2 (ja) 2007-01-18 2007-01-18 蛍光観察装置および蛍光観察装置の作動方法

Publications (1)

Publication Number Publication Date
WO2008088002A1 true WO2008088002A1 (ja) 2008-07-24

Family

ID=39636003

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/050489 WO2008088002A1 (ja) 2007-01-18 2008-01-17 蛍光観察装置および蛍光観察方法

Country Status (5)

Country Link
US (1) US8049184B2 (ja)
EP (1) EP2105082B1 (ja)
JP (1) JP5074044B2 (ja)
CN (1) CN101583304B (ja)
WO (1) WO2008088002A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8107158B2 (en) 2009-04-21 2012-01-31 Olympus Medical Systems Corp. Fluorescent imaging device and fluorescent image acquiring method
EP2412293A1 (en) * 2009-03-24 2012-02-01 Olympus Corporation Fluorescence observation device
EP2412294A1 (en) * 2009-03-24 2012-02-01 Olympus Corporation Fluorescence observation system, fluorescence observation device, and fluorescence observation method
JP2013059483A (ja) * 2011-09-13 2013-04-04 Fujifilm Corp 内視鏡診断装置

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5396121B2 (ja) 2009-03-26 2014-01-22 オリンパス株式会社 画像処理装置、撮像装置、画像処理プログラムおよび画像処理装置の作動方法
JP5506443B2 (ja) * 2010-02-10 2014-05-28 オリンパス株式会社 蛍光観察装置
JP5444377B2 (ja) * 2010-02-10 2014-03-19 オリンパス株式会社 蛍光内視鏡装置
JP5562683B2 (ja) * 2010-03-03 2014-07-30 オリンパス株式会社 蛍光観察装置
WO2011111619A1 (ja) 2010-03-09 2011-09-15 オリンパス株式会社 蛍光内視鏡装置
JP5484977B2 (ja) * 2010-03-23 2014-05-07 オリンパス株式会社 蛍光観察装置
JP5669416B2 (ja) * 2010-03-23 2015-02-12 オリンパス株式会社 蛍光観察装置
JP5558178B2 (ja) * 2010-04-07 2014-07-23 オリンパス株式会社 蛍光観察装置
JP5484997B2 (ja) 2010-04-12 2014-05-07 オリンパス株式会社 蛍光観察装置および蛍光観察装置の作動方法
JP5592715B2 (ja) * 2010-07-02 2014-09-17 オリンパス株式会社 画像処理装置および画像処理方法
JP5334952B2 (ja) 2010-12-16 2013-11-06 富士フイルム株式会社 画像処理装置
JP5984681B2 (ja) * 2011-01-31 2016-09-06 オリンパス株式会社 蛍光観察装置
JP6053673B2 (ja) * 2011-04-28 2016-12-27 オリンパス株式会社 蛍光観察装置とその画像表示方法
DE102011100507B4 (de) * 2011-04-29 2020-05-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Tragbares optisches Analysegerät
JP5802440B2 (ja) * 2011-06-02 2015-10-28 オリンパス株式会社 蛍光観察装置
CN103687529B (zh) * 2011-07-22 2016-05-18 奥林巴斯株式会社 荧光内窥镜装置
WO2013024788A1 (ja) * 2011-08-15 2013-02-21 オリンパスメディカルシステムズ株式会社 撮像装置
EP2564760A1 (en) * 2011-08-29 2013-03-06 Fujifilm Corporation Endoscopic diagnosis system
JP5926909B2 (ja) 2011-09-07 2016-05-25 オリンパス株式会社 蛍光観察装置
JP6005918B2 (ja) * 2011-09-08 2016-10-12 オリンパス株式会社 蛍光観察装置
JP6017219B2 (ja) * 2012-08-01 2016-10-26 オリンパス株式会社 蛍光観察装置および蛍光観察システム
EP3306307A4 (en) * 2015-06-02 2019-02-27 National University Corporation Asahikawa Medical University OBSERVATION SUPPORT DEVICE, INFORMATION PROCESSING PROCESS AND PROGRAM
JPWO2017006756A1 (ja) * 2015-07-09 2018-04-19 オリンパス株式会社 色素測定装置および色素測定方法
US10324041B2 (en) * 2016-12-21 2019-06-18 Abbott Japan Co., Ltd. Optical imaging system using lateral illumination for digital assays
JP7123135B2 (ja) * 2018-06-19 2022-08-22 オリンパス株式会社 内視鏡装置、内視鏡装置の作動方法及びプログラム
CN111458321B (zh) * 2020-05-22 2021-11-23 南京诺源医疗器械有限公司 一种基于病变部位荧光反馈的诊断系统

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08224208A (ja) 1995-02-22 1996-09-03 Olympus Optical Co Ltd 蛍光観察内視鏡装置
JPH10500588A (ja) * 1994-03-28 1998-01-20 ジリックス・テクノロジイズ・コーポレーション 積分された内部蛍光を使用して病気の組織の画像を映すための装置および方法
JP2003517025A (ja) * 1999-12-15 2003-05-20 シエーリング アクチエンゲゼルシャフト 近赤外蛍光造影剤及び蛍光イメージング
JP2005195379A (ja) 2003-12-31 2005-07-21 Yamaguchi Univ 腫瘍画像検出方法とその装置
JP2006175052A (ja) * 2004-12-22 2006-07-06 Fuji Photo Film Co Ltd 蛍光画像撮像装置
US20060247535A1 (en) 2005-03-23 2006-11-02 Fuji Photo Film Co., Ltd. Fluorescence detecting system

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050153356A1 (en) * 2002-09-09 2005-07-14 Olympus Corporation Image processing method for biochemical test
US20050027166A1 (en) * 2003-06-17 2005-02-03 Shinya Matsumoto Endoscope system for fluorescent observation
JP4385284B2 (ja) * 2003-12-24 2009-12-16 ソニー株式会社 撮像装置及び撮像方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10500588A (ja) * 1994-03-28 1998-01-20 ジリックス・テクノロジイズ・コーポレーション 積分された内部蛍光を使用して病気の組織の画像を映すための装置および方法
JPH08224208A (ja) 1995-02-22 1996-09-03 Olympus Optical Co Ltd 蛍光観察内視鏡装置
JP2003517025A (ja) * 1999-12-15 2003-05-20 シエーリング アクチエンゲゼルシャフト 近赤外蛍光造影剤及び蛍光イメージング
JP2005195379A (ja) 2003-12-31 2005-07-21 Yamaguchi Univ 腫瘍画像検出方法とその装置
JP2006175052A (ja) * 2004-12-22 2006-07-06 Fuji Photo Film Co Ltd 蛍光画像撮像装置
US20060247535A1 (en) 2005-03-23 2006-11-02 Fuji Photo Film Co., Ltd. Fluorescence detecting system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2105082A4

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2412293A1 (en) * 2009-03-24 2012-02-01 Olympus Corporation Fluorescence observation device
EP2412294A1 (en) * 2009-03-24 2012-02-01 Olympus Corporation Fluorescence observation system, fluorescence observation device, and fluorescence observation method
EP2412294A4 (en) * 2009-03-24 2015-03-25 Olympus Corp FLUORESCENCE OBSERVATION SYSTEM, FLUORESCENCE OBSERVATION DEVICE, AND FLUORESCENCE OBSERVATION METHOD
EP2412293A4 (en) * 2009-03-24 2015-04-15 Olympus Corp FLUORESCENCE OBSERVATION DEVICE
US8107158B2 (en) 2009-04-21 2012-01-31 Olympus Medical Systems Corp. Fluorescent imaging device and fluorescent image acquiring method
JP2013059483A (ja) * 2011-09-13 2013-04-04 Fujifilm Corp 内視鏡診断装置

Also Published As

Publication number Publication date
US20100059690A1 (en) 2010-03-11
EP2105082A1 (en) 2009-09-30
JP5074044B2 (ja) 2012-11-14
EP2105082B1 (en) 2015-08-05
EP2105082A4 (en) 2013-09-25
CN101583304A (zh) 2009-11-18
CN101583304B (zh) 2010-12-08
US8049184B2 (en) 2011-11-01
JP2008173290A (ja) 2008-07-31

Similar Documents

Publication Publication Date Title
WO2008088002A1 (ja) 蛍光観察装置および蛍光観察方法
WO2008093746A1 (ja) 蛍光観察装置および蛍光観察方法
EP1669019A3 (en) Fluorescence endoscopy device
EP2517614B1 (en) Image processing device, endoscope system, program and image processing method
US9052286B2 (en) Fluorescence endoscope apparatus
JP2011516151A5 (ja)
US20130236059A1 (en) Fluorescence reflection imaging device with two wavelengths
US9532719B2 (en) Fluorescence endoscope apparatus
EP2520211B1 (en) Fluorescence endoscope device
WO2006085252A3 (en) Optical speckle pattern investigation
EP2138977A3 (en) Image obtainment method and apparatus
CN1802560A (zh) 使用多激发－发射对和同时多信道图像检测进行荧光成像的方法和装置
JP2012245157A5 (ja) 内視鏡装置及び内視鏡装置の作動方法
WO2008078742A1 (ja) 蛍光内視鏡および蛍光測定方法
EP2123213A3 (en) Fluorescent image obtainment method and apparatus, fluorescence endoscope, and excitation-light unit
WO2008042486A3 (en) Multi-channel medical imaging systems
WO2003077749A3 (en) Medical imaging systems
EP2541467A3 (en) Sequenced Illumination for documents such as bank notes.
JP2010005056A5 (ja)
WO2006016366A3 (en) Integrated retinal imager and method
JP2009153970A (ja) 画像処理システム、画像処理方法、およびプログラム
CN102753080B (zh) 荧光内窥镜装置
Jung et al. Active blood detection in a high resolution capsule endoscopy using color spectrum transformation
JP2009153969A (ja) 位置特定システム、位置特定方法、およびプログラム
WO2012056970A1 (ja) 蛍光観察装置

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880002224.9

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08703349

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2008703349

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 12522601

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE